http://togogenome.org/gene/31033:ctps1 ^@ http://purl.uniprot.org/uniprot/H2TJ57 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/31033:mcm6 ^@ http://purl.uniprot.org/uniprot/A0A674PKG1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/31033:pim3 ^@ http://purl.uniprot.org/uniprot/A0A3B5JXH0 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.|||Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. http://togogenome.org/gene/31033:gng3 ^@ http://purl.uniprot.org/uniprot/H2RUY9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/31033:LOC101079883 ^@ http://purl.uniprot.org/uniprot/A0A674NB97 ^@ Similarity ^@ Belongs to the peroxin-13 family. http://togogenome.org/gene/31033:LOC115246453 ^@ http://purl.uniprot.org/uniprot/H2V638 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/31033:kat8 ^@ http://purl.uniprot.org/uniprot/A0A3B5K9B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/31033:cnih1 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZ95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/31033:ndufa6 ^@ http://purl.uniprot.org/uniprot/A0A674PDV5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:chmp4b ^@ http://purl.uniprot.org/uniprot/A0A674MI59 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/31033:snap25 ^@ http://purl.uniprot.org/uniprot/H2T813 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion.|||synaptosome http://togogenome.org/gene/31033:LOC101063363 ^@ http://purl.uniprot.org/uniprot/H2ST55 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/31033:scn1b ^@ http://purl.uniprot.org/uniprot/A0A674NBA5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:zdhhc5 ^@ http://purl.uniprot.org/uniprot/Q2THV8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/31033:usp10 ^@ http://purl.uniprot.org/uniprot/A0A3B5KAN1 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/31033:rtca ^@ http://purl.uniprot.org/uniprot/H2TBR3 ^@ Function|||Similarity ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. http://togogenome.org/gene/31033:ngb ^@ http://purl.uniprot.org/uniprot/A0A674MTT6 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/31033:LOC101062565 ^@ http://purl.uniprot.org/uniprot/H2T5C5 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/31033:sox21 ^@ http://purl.uniprot.org/uniprot/A0A3B5KJ66 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101068485 ^@ http://purl.uniprot.org/uniprot/H2SX79 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/31033:vps25 ^@ http://purl.uniprot.org/uniprot/H2STK3 ^@ Similarity ^@ Belongs to the VPS25 family. http://togogenome.org/gene/31033:LOC101067042 ^@ http://purl.uniprot.org/uniprot/A0A3B5JWE9 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/31033:slc25a3 ^@ http://purl.uniprot.org/uniprot/H2TRS0|||http://purl.uniprot.org/uniprot/H2TRS1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Interacts with PPIF; the interaction is impaired by CsA.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/31033:panx3 ^@ http://purl.uniprot.org/uniprot/H2S112 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/31033:LOC101075274 ^@ http://purl.uniprot.org/uniprot/A0A674NKE1 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/31033:LOC101069419 ^@ http://purl.uniprot.org/uniprot/H2TA75 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL6 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-Glycosylated. http://togogenome.org/gene/31033:LOC101078283 ^@ http://purl.uniprot.org/uniprot/H2RPT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/31033:mcoln2 ^@ http://purl.uniprot.org/uniprot/H2V6X8 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/31033:mrpl32 ^@ http://purl.uniprot.org/uniprot/H2UI20 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/31033:mcm4 ^@ http://purl.uniprot.org/uniprot/H2T1R4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/31033:LOC101071300 ^@ http://purl.uniprot.org/uniprot/H2UIG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus http://togogenome.org/gene/31033:ing1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KBY9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/31033:psmc4 ^@ http://purl.uniprot.org/uniprot/A0A674PCB6 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/31033:LOC101070008 ^@ http://purl.uniprot.org/uniprot/H2U5S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/31033:stard3 ^@ http://purl.uniprot.org/uniprot/H2UX47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/31033:LOC101070087 ^@ http://purl.uniprot.org/uniprot/A0A3B5JUJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/31033:lrfn2 ^@ http://purl.uniprot.org/uniprot/H2TI92 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:btk ^@ http://purl.uniprot.org/uniprot/Q90YI6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/31033:tspan4 ^@ http://purl.uniprot.org/uniprot/A0A674NPH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/31033:ipo7 ^@ http://purl.uniprot.org/uniprot/H2V5Z3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:naa35 ^@ http://purl.uniprot.org/uniprot/H2TAI2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MAK10 family.|||Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.|||Cytoplasm http://togogenome.org/gene/31033:enkd1 ^@ http://purl.uniprot.org/uniprot/H2UYC6 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/31033:LOC101067124 ^@ http://purl.uniprot.org/uniprot/A0A674N366 ^@ Similarity ^@ Belongs to the DENND11 family. http://togogenome.org/gene/31033:tacr1 ^@ http://purl.uniprot.org/uniprot/I4IY87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:xkr6 ^@ http://purl.uniprot.org/uniprot/Q5GH49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/31033:LOC101078548 ^@ http://purl.uniprot.org/uniprot/H2RKF3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/31033:LOC101064158 ^@ http://purl.uniprot.org/uniprot/H2UF93 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/31033:LOC101069640 ^@ http://purl.uniprot.org/uniprot/H2RQ44 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/31033:lpgat1 ^@ http://purl.uniprot.org/uniprot/A0A674NKV1 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/31033:p2rx5 ^@ http://purl.uniprot.org/uniprot/H2RPY1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/31033:mrpl10 ^@ http://purl.uniprot.org/uniprot/Q1KKW0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL10 family. http://togogenome.org/gene/31033:LOC101078618 ^@ http://purl.uniprot.org/uniprot/H2TM51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101062856 ^@ http://purl.uniprot.org/uniprot/H2T8F9 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/31033:slc26a5 ^@ http://purl.uniprot.org/uniprot/A0A674MFI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/31033:lgi1a ^@ http://purl.uniprot.org/uniprot/Q1EGK2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/31033:LOC101069851 ^@ http://purl.uniprot.org/uniprot/A0A674MPZ3 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/31033:dusp12 ^@ http://purl.uniprot.org/uniprot/H2SBS4 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/31033:bet1 ^@ http://purl.uniprot.org/uniprot/H2UR03 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:paf1 ^@ http://purl.uniprot.org/uniprot/H2SNJ1 ^@ Similarity ^@ Belongs to the PAF1 family. http://togogenome.org/gene/31033:eri1 ^@ http://purl.uniprot.org/uniprot/A0A674PQ98 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:galnt7 ^@ http://purl.uniprot.org/uniprot/A0A6D2Y1F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:LOC101063855 ^@ http://purl.uniprot.org/uniprot/H2TFV9 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/31033:LOC101065303 ^@ http://purl.uniprot.org/uniprot/H2TG29 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/31033:LOC101072117 ^@ http://purl.uniprot.org/uniprot/H2TW99 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:sfrp1 ^@ http://purl.uniprot.org/uniprot/H2SI86 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:dbx1 ^@ http://purl.uniprot.org/uniprot/H2UUI5 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:hacd2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KD36 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:pdyn ^@ http://purl.uniprot.org/uniprot/H2U1J9 ^@ Similarity ^@ Belongs to the opioid neuropeptide precursor family. http://togogenome.org/gene/31033:zbtb8os ^@ http://purl.uniprot.org/uniprot/A0A3B5K6N6 ^@ Similarity|||Subunit ^@ Belongs to the archease family.|||Component of the tRNA-splicing ligase complex. http://togogenome.org/gene/31033:fev ^@ http://purl.uniprot.org/uniprot/H2S4M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/31033:rexo2 ^@ http://purl.uniprot.org/uniprot/A0A3B5K3L7 ^@ Similarity ^@ Belongs to the oligoribonuclease family. http://togogenome.org/gene/31033:LOC101064679 ^@ http://purl.uniprot.org/uniprot/H2UUX5 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/31033:LOC101064018 ^@ http://purl.uniprot.org/uniprot/A0A3B5KBU7 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-1 subfamily. http://togogenome.org/gene/31033:LOC101067003 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZ25 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/31033:gtf2e1 ^@ http://purl.uniprot.org/uniprot/H2T3F1 ^@ Function|||Similarity ^@ Belongs to the TFIIE alpha subunit family.|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. http://togogenome.org/gene/31033:coq9 ^@ http://purl.uniprot.org/uniprot/A0A674NQ27 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COQ9 family.|||Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.|||Mitochondrion http://togogenome.org/gene/31033:jph3 ^@ http://purl.uniprot.org/uniprot/A0A674MIG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/31033:LOC101062326 ^@ http://purl.uniprot.org/uniprot/H2TKG0 ^@ Similarity ^@ Belongs to the KHDRBS family. http://togogenome.org/gene/31033:acmsd ^@ http://purl.uniprot.org/uniprot/H2T582 ^@ Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.|||Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.|||Monomer. http://togogenome.org/gene/31033:LOC101072996 ^@ http://purl.uniprot.org/uniprot/A0A3B5K3J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/31033:enpep ^@ http://purl.uniprot.org/uniprot/A0A674PGF4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/31033:rps27a ^@ http://purl.uniprot.org/uniprot/H2TSM1 ^@ Similarity ^@ In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family. http://togogenome.org/gene/31033:LOC101063036 ^@ http://purl.uniprot.org/uniprot/A0A3B5K3H6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIII family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/31033:lingo1 ^@ http://purl.uniprot.org/uniprot/H2UW86 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:rtel1 ^@ http://purl.uniprot.org/uniprot/H2TJI5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.|||Belongs to the helicase family. RAD3/XPD subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/31033:lpcat2 ^@ http://purl.uniprot.org/uniprot/H2TQX3 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/31033:tpx2 ^@ http://purl.uniprot.org/uniprot/H2TEZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TPX2 family.|||spindle http://togogenome.org/gene/31033:gata3 ^@ http://purl.uniprot.org/uniprot/H2TNQ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:rbpj ^@ http://purl.uniprot.org/uniprot/A0A674N8J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Su(H) family.|||Nucleus http://togogenome.org/gene/31033:LOC101074842 ^@ http://purl.uniprot.org/uniprot/H2SCZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/31033:tnip2 ^@ http://purl.uniprot.org/uniprot/H2SYF2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:dtd1 ^@ http://purl.uniprot.org/uniprot/H2TE46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DTD family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101077452 ^@ http://purl.uniprot.org/uniprot/A0A674MKQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/31033:LOC101061355 ^@ http://purl.uniprot.org/uniprot/H2UN98 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/31033:itm2b ^@ http://purl.uniprot.org/uniprot/H2UFI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/31033:cpne3 ^@ http://purl.uniprot.org/uniprot/H2TIA0 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/31033:LOC446095 ^@ http://purl.uniprot.org/uniprot/Q6IVY6 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/31033:mettl26 ^@ http://purl.uniprot.org/uniprot/A0A674MMJ6 ^@ Similarity ^@ Belongs to the UPF0585 family. http://togogenome.org/gene/31033:cpvl ^@ http://purl.uniprot.org/uniprot/H2URV5 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/31033:LOC101073955 ^@ http://purl.uniprot.org/uniprot/H2SE86 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:b3galt6 ^@ http://purl.uniprot.org/uniprot/Q256Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:poglut2 ^@ http://purl.uniprot.org/uniprot/H2SYE9 ^@ Similarity ^@ Belongs to the KDELC family. http://togogenome.org/gene/31033:LOC101075639 ^@ http://purl.uniprot.org/uniprot/H2T101 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:rag1 ^@ http://purl.uniprot.org/uniprot/Q9W699 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RAG1 family.|||Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).|||Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.|||Homodimer.|||Nucleus|||The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp. http://togogenome.org/gene/31033:slc39a1 ^@ http://purl.uniprot.org/uniprot/Q6QQT1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Cell membrane|||Endoplasmic reticulum membrane|||Highest levels in ovary, lower levels in intestine and gill, barely detected in kidney.|||Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space. http://togogenome.org/gene/31033:tcf7 ^@ http://purl.uniprot.org/uniprot/A0A3B5K058 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/31033:kif3c ^@ http://purl.uniprot.org/uniprot/H2RWI7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/31033:LOC101076863 ^@ http://purl.uniprot.org/uniprot/H2T4Z8 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101063351 ^@ http://purl.uniprot.org/uniprot/A0A674NN85 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/31033:LOC105417749 ^@ http://purl.uniprot.org/uniprot/H2UD64 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/31033:LOC445896 ^@ http://purl.uniprot.org/uniprot/Q6PVV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPARC family.|||extracellular matrix http://togogenome.org/gene/31033:LOC101075000 ^@ http://purl.uniprot.org/uniprot/H2UAN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101073215 ^@ http://purl.uniprot.org/uniprot/H2TZX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/31033:LOC101069818 ^@ http://purl.uniprot.org/uniprot/A0A3B5KMG3 ^@ Similarity ^@ Belongs to the pyridoxine kinase family. http://togogenome.org/gene/31033:il2rg ^@ http://purl.uniprot.org/uniprot/B6C6Q8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:KEF89_p05 ^@ http://purl.uniprot.org/uniprot/Q8HCV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4L family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/31033:stra6 ^@ http://purl.uniprot.org/uniprot/A0A3B5KUY8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:gata2 ^@ http://purl.uniprot.org/uniprot/A0A3B5JVZ9|||http://purl.uniprot.org/uniprot/A0A3B5K827 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:qtrt1 ^@ http://purl.uniprot.org/uniprot/H2UB86 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family.|||Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.|||Cytoplasm|||Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.|||Mitochondrion outer membrane http://togogenome.org/gene/31033:ccnc ^@ http://purl.uniprot.org/uniprot/H2UMX4 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/31033:LOC101075139 ^@ http://purl.uniprot.org/uniprot/A0A3B5KT25 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/31033:LOC101063219 ^@ http://purl.uniprot.org/uniprot/A0A3B5KW15 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/31033:LOC101073763 ^@ http://purl.uniprot.org/uniprot/A0A674PE77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/31033:LOC101079928 ^@ http://purl.uniprot.org/uniprot/H2RR36 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/31033:setd7 ^@ http://purl.uniprot.org/uniprot/H2T9P8 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/31033:ndufs2 ^@ http://purl.uniprot.org/uniprot/H2TZM1 ^@ Similarity ^@ Belongs to the complex I 49 kDa subunit family. http://togogenome.org/gene/31033:pdcd10 ^@ http://purl.uniprot.org/uniprot/A0A3B5KJ01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDCD10 family.|||Cell membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:apoA-IV3 ^@ http://purl.uniprot.org/uniprot/Q5KSU2 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/31033:rnt3 ^@ http://purl.uniprot.org/uniprot/Q4G5X3 ^@ Caution|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:cpm ^@ http://purl.uniprot.org/uniprot/A0A674NJ51 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/31033:nppa ^@ http://purl.uniprot.org/uniprot/Q805D8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Has a cGMP-stimulating activity (By similarity).|||Secreted http://togogenome.org/gene/31033:clstn1 ^@ http://purl.uniprot.org/uniprot/A0A674P963|||http://purl.uniprot.org/uniprot/A0A674PRJ7|||http://purl.uniprot.org/uniprot/H2TPX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calsyntenin family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Postsynaptic cell membrane http://togogenome.org/gene/31033:lep ^@ http://purl.uniprot.org/uniprot/Q588G0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the leptin family.|||Expressed mostly in the liver.|||May function as part of a signaling pathway that acts to regulate the size of the body fat depot.|||Secreted http://togogenome.org/gene/31033:LOC101065673 ^@ http://purl.uniprot.org/uniprot/H2UWU3 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/31033:pdxp ^@ http://purl.uniprot.org/uniprot/H2V0P2 ^@ Cofactor|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||Divalent metal ions. Mg(2+) is the most effective. http://togogenome.org/gene/31033:eif3l ^@ http://purl.uniprot.org/uniprot/H2V812 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit L family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm http://togogenome.org/gene/31033:nsa2 ^@ http://purl.uniprot.org/uniprot/A0A674P4V0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.|||nucleolus http://togogenome.org/gene/31033:LOC101061221 ^@ http://purl.uniprot.org/uniprot/A0A674PFB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Membrane http://togogenome.org/gene/31033:tmem167a ^@ http://purl.uniprot.org/uniprot/A0A674NN01 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Membrane http://togogenome.org/gene/31033:LOC101069649 ^@ http://purl.uniprot.org/uniprot/H2UHS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/31033:pithd1 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZZ0 ^@ Similarity ^@ Belongs to the PITHD1 family. http://togogenome.org/gene/31033:tspan9 ^@ http://purl.uniprot.org/uniprot/H2UM51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/31033:ing2 ^@ http://purl.uniprot.org/uniprot/A0A674NND1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/31033:stk32a ^@ http://purl.uniprot.org/uniprot/H2RRI3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:LOC101075406 ^@ http://purl.uniprot.org/uniprot/H2UX75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.|||Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/31033:lclat1 ^@ http://purl.uniprot.org/uniprot/A0A3B5JVL8 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/31033:dna2 ^@ http://purl.uniprot.org/uniprot/H2SI79 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family.|||Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.|||Mitochondrion|||Nucleus http://togogenome.org/gene/31033:LOC101077433 ^@ http://purl.uniprot.org/uniprot/H2TH34 ^@ Similarity ^@ Belongs to the bZIP family. NFIL3 subfamily. http://togogenome.org/gene/31033:LOC101063177 ^@ http://purl.uniprot.org/uniprot/A0A674NCB8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:kifc3 ^@ http://purl.uniprot.org/uniprot/H2S1X6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/31033:tmem41a ^@ http://purl.uniprot.org/uniprot/H2TN18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/31033:nck1 ^@ http://purl.uniprot.org/uniprot/H2V8B5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/31033:galnt9 ^@ http://purl.uniprot.org/uniprot/A0A674M8N8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:LOC101069509 ^@ http://purl.uniprot.org/uniprot/H2VE74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:tmcc1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KDF7|||http://purl.uniprot.org/uniprot/A0A3B5KI44|||http://purl.uniprot.org/uniprot/H2TVW7 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/31033:ap1m2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KB89 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Golgi apparatus|||Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.|||clathrin-coated vesicle membrane http://togogenome.org/gene/31033:agtr1 ^@ http://purl.uniprot.org/uniprot/H2V8H5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. http://togogenome.org/gene/31033:LOC101073747 ^@ http://purl.uniprot.org/uniprot/A0A674MVC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/31033:lipg ^@ http://purl.uniprot.org/uniprot/H2V0C9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/31033:LOC101063572 ^@ http://purl.uniprot.org/uniprot/H2SN66 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:sirt4 ^@ http://purl.uniprot.org/uniprot/H2UPJ5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sirtuin family. Class II subfamily.|||Binds 1 zinc ion per subunit.|||Mitochondrion matrix|||NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. http://togogenome.org/gene/31033:acp5 ^@ http://purl.uniprot.org/uniprot/H2T6X7 ^@ Cofactor ^@ Binds 2 iron ions per subunit. http://togogenome.org/gene/31033:LOC101064909 ^@ http://purl.uniprot.org/uniprot/H2RJG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. http://togogenome.org/gene/31033:LOC101077547 ^@ http://purl.uniprot.org/uniprot/H2TUH4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:tbpl1 ^@ http://purl.uniprot.org/uniprot/A6H915 ^@ Similarity ^@ Belongs to the TBP family. http://togogenome.org/gene/31033:rpl7 ^@ http://purl.uniprot.org/uniprot/A0A674NKS7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/31033:LOC101076820 ^@ http://purl.uniprot.org/uniprot/A0A3B5K9Q1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/31033:zic5 ^@ http://purl.uniprot.org/uniprot/H2TYM7 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/31033:LOC101062685 ^@ http://purl.uniprot.org/uniprot/A0A674MIH3|||http://purl.uniprot.org/uniprot/A0A674MXC7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOTCH family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Nucleus http://togogenome.org/gene/31033:fibin ^@ http://purl.uniprot.org/uniprot/H2UY08 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FIBIN family.|||Endoplasmic reticulum|||Golgi apparatus|||Homodimer; disulfide-linked. Seems to also exist as monomers.|||Secreted http://togogenome.org/gene/31033:LOC101065968 ^@ http://purl.uniprot.org/uniprot/A0A674P0L2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF alpha subunit family.|||Nucleus|||TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. http://togogenome.org/gene/31033:map1lc3c ^@ http://purl.uniprot.org/uniprot/A0A674MLR2 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/31033:tmem151b ^@ http://purl.uniprot.org/uniprot/A0A3B5KCG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM151 family.|||Membrane http://togogenome.org/gene/31033:ppm1f ^@ http://purl.uniprot.org/uniprot/H2SC72 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/31033:tmem39b ^@ http://purl.uniprot.org/uniprot/H2U1D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/31033:cldn27a ^@ http://purl.uniprot.org/uniprot/Q6E5Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/31033:rnf170 ^@ http://purl.uniprot.org/uniprot/H2RNU7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:LOC101073225 ^@ http://purl.uniprot.org/uniprot/H2U8P4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:thoc5 ^@ http://purl.uniprot.org/uniprot/A0A674PFK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC5 family.|||Nucleus http://togogenome.org/gene/31033:LOC101073449 ^@ http://purl.uniprot.org/uniprot/H2UJI0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/31033:LOC101065341 ^@ http://purl.uniprot.org/uniprot/H2TXE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the taffazin family.|||Mitochondrion inner membrane|||Mitochondrion outer membrane http://togogenome.org/gene/31033:LOC101078620 ^@ http://purl.uniprot.org/uniprot/A0A3B5JYC3|||http://purl.uniprot.org/uniprot/A0A3B5KND4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:atg4c ^@ http://purl.uniprot.org/uniprot/H2VDW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/31033:LOC101075102 ^@ http://purl.uniprot.org/uniprot/H2RRQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/31033:LOC101073250 ^@ http://purl.uniprot.org/uniprot/A0A674MEW1 ^@ Function|||Similarity ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs. http://togogenome.org/gene/31033:acy1 ^@ http://purl.uniprot.org/uniprot/H2UHE2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Binds 2 Zn(2+) ions per subunit.|||Cytoplasm http://togogenome.org/gene/31033:vegfc ^@ http://purl.uniprot.org/uniprot/H2TYL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Secreted http://togogenome.org/gene/31033:get1 ^@ http://purl.uniprot.org/uniprot/H2RSA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WRB/GET1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:gng7 ^@ http://purl.uniprot.org/uniprot/H2UW32 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/31033:LOC101064433 ^@ http://purl.uniprot.org/uniprot/H2UYX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cleavage furrow|||Midbody|||cilium membrane|||spindle http://togogenome.org/gene/31033:LOC101069337 ^@ http://purl.uniprot.org/uniprot/H2SRW1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:atp5mc3 ^@ http://purl.uniprot.org/uniprot/Q1KKT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/31033:nptx1 ^@ http://purl.uniprot.org/uniprot/H2SES0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:myod2 ^@ http://purl.uniprot.org/uniprot/Q202D3 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/31033:LOC101067274 ^@ http://purl.uniprot.org/uniprot/A0A3B5KKZ0 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/31033:LOC101074871 ^@ http://purl.uniprot.org/uniprot/A0A674MC65 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/31033:pym1 ^@ http://purl.uniprot.org/uniprot/A0A674NNC8 ^@ Similarity|||Subunit ^@ Belongs to the pym family.|||Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex. http://togogenome.org/gene/31033:LOC101078309 ^@ http://purl.uniprot.org/uniprot/A0A674NYB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:tcp1 ^@ http://purl.uniprot.org/uniprot/H2SQ27 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/31033:LOC101075730 ^@ http://purl.uniprot.org/uniprot/H2SJY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Endosome|||Membrane|||Perikaryon|||axon|||dendrite http://togogenome.org/gene/31033:LOC101072748 ^@ http://purl.uniprot.org/uniprot/A0A674P7L7 ^@ Similarity ^@ Belongs to the AFG1 ATPase family. http://togogenome.org/gene/31033:mct4a ^@ http://purl.uniprot.org/uniprot/H1ABV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/31033:rfrp ^@ http://purl.uniprot.org/uniprot/Q05KN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FARP (FMRFamide related peptide) family.|||Secreted http://togogenome.org/gene/31033:brk1 ^@ http://purl.uniprot.org/uniprot/H2T7T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BRK1 family.|||cytoskeleton http://togogenome.org/gene/31033:rhag-2 ^@ http://purl.uniprot.org/uniprot/Q7T3R7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Cell membrane|||Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.|||Membrane http://togogenome.org/gene/31033:tmem167b ^@ http://purl.uniprot.org/uniprot/A0A3B5KFA6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:npy4r ^@ http://purl.uniprot.org/uniprot/A7XY84 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:nt5c2 ^@ http://purl.uniprot.org/uniprot/A0A674MYM4 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/31033:tfap2a ^@ http://purl.uniprot.org/uniprot/A0A674MED6|||http://purl.uniprot.org/uniprot/A0A674P0A4|||http://purl.uniprot.org/uniprot/H2SNY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AP-2 family.|||Nucleus http://togogenome.org/gene/31033:anapc4 ^@ http://purl.uniprot.org/uniprot/H2UJE7 ^@ Function|||Similarity ^@ Belongs to the APC4 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/31033:junb ^@ http://purl.uniprot.org/uniprot/Q800B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/31033:ncam1 ^@ http://purl.uniprot.org/uniprot/A0A674MQD5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:rnf145 ^@ http://purl.uniprot.org/uniprot/H2UF44 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:gpat4 ^@ http://purl.uniprot.org/uniprot/H2SA56 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/31033:cdc5l ^@ http://purl.uniprot.org/uniprot/A0A3B5K703 ^@ Similarity ^@ Belongs to the CEF1 family. http://togogenome.org/gene/31033:pxmp4 ^@ http://purl.uniprot.org/uniprot/H2VDF3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Interacts with PEX19.|||Peroxisome membrane http://togogenome.org/gene/31033:myf6 ^@ http://purl.uniprot.org/uniprot/Q6SYV5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity).|||Nucleus http://togogenome.org/gene/31033:LOC101075245 ^@ http://purl.uniprot.org/uniprot/H2V022 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/31033:LOC101078143 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZJ1 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.|||Nucleus http://togogenome.org/gene/31033:actn3 ^@ http://purl.uniprot.org/uniprot/H2SND8 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/31033:dtx1 ^@ http://purl.uniprot.org/uniprot/H2T1I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/31033:ca6 ^@ http://purl.uniprot.org/uniprot/H2TB98 ^@ Caution|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:slc7a14 ^@ http://purl.uniprot.org/uniprot/A0A674PQW7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:gclm ^@ http://purl.uniprot.org/uniprot/H2RNS3 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.|||Heterodimer of a catalytic heavy chain and a regulatory light chain. http://togogenome.org/gene/31033:hlf ^@ http://purl.uniprot.org/uniprot/H2S8P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/31033:gcnt4 ^@ http://purl.uniprot.org/uniprot/H2UAR1 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:LOC101079659 ^@ http://purl.uniprot.org/uniprot/H2SCT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:ablim3 ^@ http://purl.uniprot.org/uniprot/A0A674P1T7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:LOC101067984 ^@ http://purl.uniprot.org/uniprot/H2ULJ5 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/31033:LOC101074526 ^@ http://purl.uniprot.org/uniprot/H2THB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calreticulin family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/31033:LOC115246436 ^@ http://purl.uniprot.org/uniprot/H2TAR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/31033:LOC101070321 ^@ http://purl.uniprot.org/uniprot/H2TUF5 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/31033:rhbg ^@ http://purl.uniprot.org/uniprot/Q18PF6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Apicolateral cell membrane|||Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Cytoplasmic vesicle membrane|||Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.|||Specifically expressed in the gill by pavement cells (at protein level). http://togogenome.org/gene/31033:tmcc3 ^@ http://purl.uniprot.org/uniprot/H2UNY3 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/31033:LOC101062905 ^@ http://purl.uniprot.org/uniprot/A0A3B5KMF1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/31033:mrpl58 ^@ http://purl.uniprot.org/uniprot/A0A674PRV8 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/31033:dlx6 ^@ http://purl.uniprot.org/uniprot/H2T261 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:slc35a1 ^@ http://purl.uniprot.org/uniprot/Q50J29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:sbno1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KA72 ^@ Similarity ^@ Belongs to the SBNO family. http://togogenome.org/gene/31033:gna12 ^@ http://purl.uniprot.org/uniprot/H2TWM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-alpha family. G(12) subfamily.|||Membrane http://togogenome.org/gene/31033:LOC101064836 ^@ http://purl.uniprot.org/uniprot/H2USX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101075532 ^@ http://purl.uniprot.org/uniprot/H2SW92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PUR DNA-binding protein family.|||Nucleus http://togogenome.org/gene/31033:slc17a6 ^@ http://purl.uniprot.org/uniprot/A0A674NVQ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101069325 ^@ http://purl.uniprot.org/uniprot/A0A674PEX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/31033:LOC101066709 ^@ http://purl.uniprot.org/uniprot/H2RNT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. http://togogenome.org/gene/31033:pdhb ^@ http://purl.uniprot.org/uniprot/H2RZ13 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. http://togogenome.org/gene/31033:ddit3 ^@ http://purl.uniprot.org/uniprot/A0A3B5K2B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family.|||Cytoplasm http://togogenome.org/gene/31033:fut8 ^@ http://purl.uniprot.org/uniprot/Q6EV74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 23 family.|||Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/31033:grk4 ^@ http://purl.uniprot.org/uniprot/A0A674NES3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/31033:negr1 ^@ http://purl.uniprot.org/uniprot/A0A674MA17|||http://purl.uniprot.org/uniprot/A0A674NCQ1|||http://purl.uniprot.org/uniprot/A0A674PPC7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:rragc ^@ http://purl.uniprot.org/uniprot/H2TEY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/31033:myo1b ^@ http://purl.uniprot.org/uniprot/H2SCL2|||http://purl.uniprot.org/uniprot/H2SCL3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/31033:ghitm ^@ http://purl.uniprot.org/uniprot/H2TXC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/31033:pfdn1 ^@ http://purl.uniprot.org/uniprot/A0A674MF53 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/31033:LOC101076120 ^@ http://purl.uniprot.org/uniprot/H2U4R3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/31033:LOC101076333 ^@ http://purl.uniprot.org/uniprot/H2SBK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Golgi pH regulator (TC 1.A.38) family.|||Membrane http://togogenome.org/gene/31033:LOC101072357 ^@ http://purl.uniprot.org/uniprot/A0A674NP71 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/31033:ankrd13b ^@ http://purl.uniprot.org/uniprot/A0A674PS19 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/31033:dnmbp ^@ http://purl.uniprot.org/uniprot/H2U900 ^@ Subcellular Location Annotation ^@ Cell junction|||Golgi stack|||Synapse|||cytoskeleton http://togogenome.org/gene/31033:poc5 ^@ http://purl.uniprot.org/uniprot/A0A3B5KMW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POC5 family.|||Essential for the assembly of the distal half of centrioles, required for centriole elongation.|||centriole http://togogenome.org/gene/31033:LOC446072 ^@ http://purl.uniprot.org/uniprot/Q804X2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular space http://togogenome.org/gene/31033:LOC101078823 ^@ http://purl.uniprot.org/uniprot/A0A3B5KDP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/31033:LOC101070461 ^@ http://purl.uniprot.org/uniprot/H2UQR1 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/31033:LOC101071080 ^@ http://purl.uniprot.org/uniprot/A0A674NY09 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:LOC101078944 ^@ http://purl.uniprot.org/uniprot/H2TBK8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:tlr3 ^@ http://purl.uniprot.org/uniprot/A0A3B5K0I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/31033:LOC101070267 ^@ http://purl.uniprot.org/uniprot/A0A674P3B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/31033:LOC101064317 ^@ http://purl.uniprot.org/uniprot/A0A674P414 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101067626 ^@ http://purl.uniprot.org/uniprot/H2TMN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101072045 ^@ http://purl.uniprot.org/uniprot/A0A3B5KLI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/31033:rnf8 ^@ http://purl.uniprot.org/uniprot/H2SP55 ^@ Similarity ^@ Belongs to the CHFR family.|||Belongs to the RNF8 family. http://togogenome.org/gene/31033:atp5f1d ^@ http://purl.uniprot.org/uniprot/H2VAT0 ^@ Similarity ^@ Belongs to the ATPase epsilon chain family. http://togogenome.org/gene/31033:mtmr11 ^@ http://purl.uniprot.org/uniprot/A0A674MM04 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/31033:LOC101063742 ^@ http://purl.uniprot.org/uniprot/H2SSZ7 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:eif4e2 ^@ http://purl.uniprot.org/uniprot/H2UJV2 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/31033:mrpl15 ^@ http://purl.uniprot.org/uniprot/H2T1U6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/31033:LOC101064208 ^@ http://purl.uniprot.org/uniprot/H2U9I1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:rpl35a ^@ http://purl.uniprot.org/uniprot/H2S7F0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/31033:LOC101074909 ^@ http://purl.uniprot.org/uniprot/A0A674N8W7 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/31033:KEF89_p02 ^@ http://purl.uniprot.org/uniprot/Q8HCV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 6 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion membrane http://togogenome.org/gene/31033:dolpp1 ^@ http://purl.uniprot.org/uniprot/H2VCR2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dolichyldiphosphatase family.|||Endoplasmic reticulum membrane|||Membrane|||Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. http://togogenome.org/gene/31033:dusp6 ^@ http://purl.uniprot.org/uniprot/Q8UW48 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/31033:st8sia5 ^@ http://purl.uniprot.org/uniprot/Q6KC01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/31033:LOC101061775 ^@ http://purl.uniprot.org/uniprot/A0A3B5K482 ^@ Function|||Similarity ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs. http://togogenome.org/gene/31033:LOC101071755 ^@ http://purl.uniprot.org/uniprot/H2TJZ1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the InsP3 receptor family.|||Endoplasmic reticulum membrane|||Homotetramer.|||Membrane|||Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.|||The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. http://togogenome.org/gene/31033:LOC101073735 ^@ http://purl.uniprot.org/uniprot/H2UIK7|||http://purl.uniprot.org/uniprot/H2UIK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/31033:samd8 ^@ http://purl.uniprot.org/uniprot/H2UD38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/31033:oaz1 ^@ http://purl.uniprot.org/uniprot/H2V981 ^@ Similarity ^@ Belongs to the ODC antizyme family. http://togogenome.org/gene/31033:nkx2-3 ^@ http://purl.uniprot.org/uniprot/A0A3B5K9U3 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:foxe1 ^@ http://purl.uniprot.org/uniprot/H2TQJ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101079165 ^@ http://purl.uniprot.org/uniprot/H2UM08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GnRH family.|||Secreted|||Stimulates the secretion of gonadotropins. http://togogenome.org/gene/31033:LOC101069053 ^@ http://purl.uniprot.org/uniprot/A0A674MN56|||http://purl.uniprot.org/uniprot/A0A674N8F2 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/31033:sh3pxd2b ^@ http://purl.uniprot.org/uniprot/H2RVN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SH3PXD2 family.|||Cytoplasm http://togogenome.org/gene/31033:syp ^@ http://purl.uniprot.org/uniprot/H2RVX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/31033:LOC101067992 ^@ http://purl.uniprot.org/uniprot/A0A674MTQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/31033:qars ^@ http://purl.uniprot.org/uniprot/A0A674PH57 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/31033:LOC101080225 ^@ http://purl.uniprot.org/uniprot/H2TZM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:cldn5 ^@ http://purl.uniprot.org/uniprot/Q6E5U6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:otop1 ^@ http://purl.uniprot.org/uniprot/Q7M555 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101074725 ^@ http://purl.uniprot.org/uniprot/A0A674PPS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity.|||Membrane http://togogenome.org/gene/31033:LOC101066300 ^@ http://purl.uniprot.org/uniprot/A0A3B5K749 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:rpl28 ^@ http://purl.uniprot.org/uniprot/A0A674MSW0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL28 family. http://togogenome.org/gene/31033:LOC101078102 ^@ http://purl.uniprot.org/uniprot/A0A674MKD7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/31033:uchl3 ^@ http://purl.uniprot.org/uniprot/H2TQ79 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/31033:cpt2 ^@ http://purl.uniprot.org/uniprot/H2V041 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/31033:LOC101071937 ^@ http://purl.uniprot.org/uniprot/H2V462 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/31033:shh ^@ http://purl.uniprot.org/uniprot/Q8AXT0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hedgehog family.|||Cell membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Multimer.|||The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.|||The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. http://togogenome.org/gene/31033:LOC101070249 ^@ http://purl.uniprot.org/uniprot/H2UZK4 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/31033:LOC101062165 ^@ http://purl.uniprot.org/uniprot/H2TWV0 ^@ Similarity ^@ Belongs to the pellino family. http://togogenome.org/gene/31033:btd ^@ http://purl.uniprot.org/uniprot/Q8AV84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.|||Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.|||extracellular space http://togogenome.org/gene/31033:dazap2 ^@ http://purl.uniprot.org/uniprot/Q5QHQ9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus speckle|||nuclear body http://togogenome.org/gene/31033:LOC101068629 ^@ http://purl.uniprot.org/uniprot/A0A3B5JXE7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:zfp36l2 ^@ http://purl.uniprot.org/uniprot/A0A674PGX2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Nucleus|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/31033:ccdc43 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZ64 ^@ Similarity ^@ Belongs to the CCDC43 family. http://togogenome.org/gene/31033:igf1 ^@ http://purl.uniprot.org/uniprot/B6F213 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/31033:cwf19l2 ^@ http://purl.uniprot.org/uniprot/H2SZG5 ^@ Similarity ^@ Belongs to the CWF19 family. http://togogenome.org/gene/31033:LOC101067448 ^@ http://purl.uniprot.org/uniprot/H2TT57 ^@ Similarity|||Subunit ^@ Belongs to the 14-3-3 family.|||Homodimer, and heterodimer with other family members. http://togogenome.org/gene/31033:dio3a ^@ http://purl.uniprot.org/uniprot/B1B571 ^@ Function|||Similarity ^@ Belongs to the iodothyronine deiodinase family.|||Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine). http://togogenome.org/gene/31033:cpn1 ^@ http://purl.uniprot.org/uniprot/H2U9J6 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/31033:LOC101076056 ^@ http://purl.uniprot.org/uniprot/H2TBU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/31033:LOC101068011 ^@ http://purl.uniprot.org/uniprot/A0A3B5KA00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/31033:araf ^@ http://purl.uniprot.org/uniprot/Q5NSW1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/31033:pomt2 ^@ http://purl.uniprot.org/uniprot/A0A674MI13|||http://purl.uniprot.org/uniprot/H2UQD9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/31033:dll1 ^@ http://purl.uniprot.org/uniprot/A0A674PKL7 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/31033:LOC101071264 ^@ http://purl.uniprot.org/uniprot/H2TEQ4 ^@ Similarity ^@ Belongs to the vacuolar ATPase subunit S1 family. http://togogenome.org/gene/31033:LOC101068811 ^@ http://purl.uniprot.org/uniprot/A0A3B5K7W8 ^@ Similarity ^@ Belongs to the nanos family. http://togogenome.org/gene/31033:LOC101075987 ^@ http://purl.uniprot.org/uniprot/H2UFU9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101065545 ^@ http://purl.uniprot.org/uniprot/H2V7M4 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/31033:rasgrp2 ^@ http://purl.uniprot.org/uniprot/H2U1D4 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/31033:jak1 ^@ http://purl.uniprot.org/uniprot/A0A674NBS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.|||Endomembrane system http://togogenome.org/gene/31033:vamp7 ^@ http://purl.uniprot.org/uniprot/A0A3B5KHW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/31033:cdkn1b ^@ http://purl.uniprot.org/uniprot/A0A3B5KDR9 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/31033:LOC101070984 ^@ http://purl.uniprot.org/uniprot/H2TS81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/31033:LOC101068336 ^@ http://purl.uniprot.org/uniprot/A0A674MCY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IWR1/SLC7A6OS family.|||Cytoplasm|||Directs RNA polymerase II nuclear import.|||Nucleus http://togogenome.org/gene/31033:nfe2l1 ^@ http://purl.uniprot.org/uniprot/H2U273 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/31033:nts ^@ http://purl.uniprot.org/uniprot/H2RTX4|||http://purl.uniprot.org/uniprot/Q5TLU5 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/31033:fgf3 ^@ http://purl.uniprot.org/uniprot/A0A674NKG2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/31033:alcam ^@ http://purl.uniprot.org/uniprot/A0S0K9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:mrpl16 ^@ http://purl.uniprot.org/uniprot/H2V4K4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/31033:oprl1 ^@ http://purl.uniprot.org/uniprot/A0A674MMX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101074356 ^@ http://purl.uniprot.org/uniprot/A0A674P297 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/31033:LOC101079108 ^@ http://purl.uniprot.org/uniprot/A0A674MZ81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLPTM1 family.|||Membrane http://togogenome.org/gene/31033:ndufb9 ^@ http://purl.uniprot.org/uniprot/A0A674NNR8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:LOC101076602 ^@ http://purl.uniprot.org/uniprot/H2VDF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hcp beta-lactamase family.|||Mitochondrion intermembrane space|||Required for assembly of mitochondrial respiratory chain complexes. http://togogenome.org/gene/31033:rfx2 ^@ http://purl.uniprot.org/uniprot/H2TBN7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:znf711 ^@ http://purl.uniprot.org/uniprot/A0A3B5KK06 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:itgb4 ^@ http://purl.uniprot.org/uniprot/H2SP20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101078091 ^@ http://purl.uniprot.org/uniprot/H2T5Z9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the argonaute family. Ago subfamily.|||P-body|||Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. http://togogenome.org/gene/31033:LOC101074797 ^@ http://purl.uniprot.org/uniprot/Q6E5Q2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:adi1 ^@ http://purl.uniprot.org/uniprot/H2SK08 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acireductone dioxygenase (ARD) family.|||Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.|||Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.|||Cell membrane|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/31033:wars2 ^@ http://purl.uniprot.org/uniprot/H2UVY7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/31033:eif2s1 ^@ http://purl.uniprot.org/uniprot/H2V9Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2-alpha family.|||Stress granule http://togogenome.org/gene/31033:LOC101062644 ^@ http://purl.uniprot.org/uniprot/A0A3B5KER9 ^@ Similarity ^@ Belongs to the FAM219 family. http://togogenome.org/gene/31033:cnnm4 ^@ http://purl.uniprot.org/uniprot/H2UV60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ACDP family.|||Cell membrane|||Membrane|||Metal transporter. http://togogenome.org/gene/31033:LOC101075233 ^@ http://purl.uniprot.org/uniprot/H2SS84 ^@ Similarity ^@ Belongs to the parvin family. http://togogenome.org/gene/31033:ets1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K0T6|||http://purl.uniprot.org/uniprot/A0A3B5KH81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/31033:LOC101065671 ^@ http://purl.uniprot.org/uniprot/H2TSQ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. http://togogenome.org/gene/31033:rpl3l ^@ http://purl.uniprot.org/uniprot/A0A674NUS0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/31033:slc15a4 ^@ http://purl.uniprot.org/uniprot/H2TPL0|||http://purl.uniprot.org/uniprot/H2TPL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Membrane http://togogenome.org/gene/31033:banp ^@ http://purl.uniprot.org/uniprot/H2SGT5 ^@ Similarity ^@ Belongs to the BANP/SMAR1 family. http://togogenome.org/gene/31033:psat1 ^@ http://purl.uniprot.org/uniprot/H2RNU2 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.|||Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. http://togogenome.org/gene/31033:tmem45a ^@ http://purl.uniprot.org/uniprot/H2TXW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/31033:LOC101061332 ^@ http://purl.uniprot.org/uniprot/A0A674PLX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Nucleus http://togogenome.org/gene/31033:LOC101071742 ^@ http://purl.uniprot.org/uniprot/H2V550 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/31033:dlx1 ^@ http://purl.uniprot.org/uniprot/H2V8E3 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:tie1 ^@ http://purl.uniprot.org/uniprot/H2VDJ8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:dpp3 ^@ http://purl.uniprot.org/uniprot/H2TEX3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M49 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/31033:LOC101076447 ^@ http://purl.uniprot.org/uniprot/H2TA64 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIT family. FIT1 subfamily.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May play a role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol.|||Membrane http://togogenome.org/gene/31033:sdr16c5 ^@ http://purl.uniprot.org/uniprot/H2TMG5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/31033:LOC445936 ^@ http://purl.uniprot.org/uniprot/H2TEJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/31033:eaf1 ^@ http://purl.uniprot.org/uniprot/A0A674N9T7 ^@ Similarity ^@ Belongs to the EAF family. http://togogenome.org/gene/31033:cacng5 ^@ http://purl.uniprot.org/uniprot/A0A674MAW0 ^@ Similarity ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. http://togogenome.org/gene/31033:dntt ^@ http://purl.uniprot.org/uniprot/Q75U67 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Nucleus|||Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. http://togogenome.org/gene/31033:cygb ^@ http://purl.uniprot.org/uniprot/H2U139 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/31033:amacr ^@ http://purl.uniprot.org/uniprot/H2UIN6 ^@ Similarity ^@ Belongs to the CoA-transferase III family. http://togogenome.org/gene/31033:LOC101072650 ^@ http://purl.uniprot.org/uniprot/H2SSP7 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/31033:LOC101078981 ^@ http://purl.uniprot.org/uniprot/A0A3B5KK66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Early endosome|||Endosome|||Involved in trafficking and recycling of synaptic vesicles.|||Late endosome|||Membrane|||Recycling endosome|||autophagosome|||synaptic vesicle|||trans-Golgi network http://togogenome.org/gene/31033:rpl7a ^@ http://purl.uniprot.org/uniprot/O57592 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm http://togogenome.org/gene/31033:tmem199 ^@ http://purl.uniprot.org/uniprot/A0A3B5KJI4 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:agps ^@ http://purl.uniprot.org/uniprot/Q1KKS4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FAD-binding oxidoreductase/transferase type 4 family.|||Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.|||Homodimer.|||Peroxisome http://togogenome.org/gene/31033:dxo ^@ http://purl.uniprot.org/uniprot/A0A3B5KK98 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DXO/Dom3Z family.|||Binds 2 magnesium ions.|||Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.|||Nucleus http://togogenome.org/gene/31033:pdcl3 ^@ http://purl.uniprot.org/uniprot/H2UNB6 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/31033:LOC101076659 ^@ http://purl.uniprot.org/uniprot/A0A674PGT6 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/31033:trappc3 ^@ http://purl.uniprot.org/uniprot/H2UTE5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/31033:LOC101066950 ^@ http://purl.uniprot.org/uniprot/H2SY89 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/31033:rps3a ^@ http://purl.uniprot.org/uniprot/H2UNW7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).|||Cytoplasm|||nucleolus http://togogenome.org/gene/31033:slc39a11 ^@ http://purl.uniprot.org/uniprot/A0A3B5K362 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:scgn ^@ http://purl.uniprot.org/uniprot/A0A3B5JY92 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:mknk2 ^@ http://purl.uniprot.org/uniprot/A0A674N8L9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:plac8 ^@ http://purl.uniprot.org/uniprot/A0A674NIN5 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/31033:LOC101072151 ^@ http://purl.uniprot.org/uniprot/H2SDT4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:LOC101075404 ^@ http://purl.uniprot.org/uniprot/A0A3B5K4R8 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/31033:itfg1 ^@ http://purl.uniprot.org/uniprot/H2TIZ6 ^@ Similarity ^@ Belongs to the TIP family. http://togogenome.org/gene/31033:gpr119 ^@ http://purl.uniprot.org/uniprot/Q7T2L4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:suclg1 ^@ http://purl.uniprot.org/uniprot/A0A674NRV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).|||Mitochondrion|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. http://togogenome.org/gene/31033:avpr1a ^@ http://purl.uniprot.org/uniprot/Q5MZ02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101075840 ^@ http://purl.uniprot.org/uniprot/H2USI4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:LOC101078875 ^@ http://purl.uniprot.org/uniprot/H2SX46 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:yif1a ^@ http://purl.uniprot.org/uniprot/H2U1G6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Membrane http://togogenome.org/gene/31033:LOC101068778 ^@ http://purl.uniprot.org/uniprot/A0A3B5KB22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.|||Endomembrane system|||Nucleus http://togogenome.org/gene/31033:bud23 ^@ http://purl.uniprot.org/uniprot/H2T7J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:pycr3 ^@ http://purl.uniprot.org/uniprot/A0A3B5KMV6 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/31033:imp3 ^@ http://purl.uniprot.org/uniprot/A0A674MEA5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/31033:LOC101078768 ^@ http://purl.uniprot.org/uniprot/A0A3B5KEC8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/31033:LOC101063462 ^@ http://purl.uniprot.org/uniprot/H2TA80 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/31033:LOC101070011 ^@ http://purl.uniprot.org/uniprot/A0A3B5KC04 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/31033:kin ^@ http://purl.uniprot.org/uniprot/A0A674MZF0 ^@ Similarity ^@ Belongs to the KIN17 family. http://togogenome.org/gene/31033:gabra2 ^@ http://purl.uniprot.org/uniprot/A0A674NQY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/31033:cav1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KAY2|||http://purl.uniprot.org/uniprot/Q9YGM8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||Homooligomer.|||May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||Membrane raft|||caveola http://togogenome.org/gene/31033:emx2 ^@ http://purl.uniprot.org/uniprot/A0A3B5K4I3 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101077048 ^@ http://purl.uniprot.org/uniprot/A0A3B5KB16 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/31033:LOC101064546 ^@ http://purl.uniprot.org/uniprot/H2TLJ3 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/31033:cnnm3 ^@ http://purl.uniprot.org/uniprot/A0A097ZIH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ACDP family.|||Cell membrane|||Membrane|||Metal transporter. http://togogenome.org/gene/31033:hs3st5 ^@ http://purl.uniprot.org/uniprot/H2SVZ8 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/31033:pemt ^@ http://purl.uniprot.org/uniprot/H2V443 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.|||Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/31033:cep19 ^@ http://purl.uniprot.org/uniprot/A0A674MNE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP19 family.|||centriole|||cilium basal body|||spindle pole http://togogenome.org/gene/31033:rab5if ^@ http://purl.uniprot.org/uniprot/A0A3B5JZA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:plpp3 ^@ http://purl.uniprot.org/uniprot/A0A3B5K387|||http://purl.uniprot.org/uniprot/H2UY52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/31033:LOC101065923 ^@ http://purl.uniprot.org/uniprot/H2VB92 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101068223 ^@ http://purl.uniprot.org/uniprot/A0A3B5KMT1 ^@ Similarity ^@ Belongs to the COX20 family. http://togogenome.org/gene/31033:pex10 ^@ http://purl.uniprot.org/uniprot/A0A674NUB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/31033:tlcd1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KG49 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC446040 ^@ http://purl.uniprot.org/uniprot/Q6SYV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Secreted http://togogenome.org/gene/31033:b3gat1 ^@ http://purl.uniprot.org/uniprot/A0A674MA33|||http://purl.uniprot.org/uniprot/Q5CB00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:LOC101064174 ^@ http://purl.uniprot.org/uniprot/A0A3B5K053 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:LOC101067125 ^@ http://purl.uniprot.org/uniprot/H2TFV3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:LOC101078390 ^@ http://purl.uniprot.org/uniprot/H2S8S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/31033:LOC101061248 ^@ http://purl.uniprot.org/uniprot/H2UWB5 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/31033:ppp4r2 ^@ http://purl.uniprot.org/uniprot/H2THS9 ^@ Similarity ^@ Belongs to the PPP4R2 family. http://togogenome.org/gene/31033:pde1c ^@ http://purl.uniprot.org/uniprot/H2U1H1 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/31033:csnk2a2 ^@ http://purl.uniprot.org/uniprot/H2T3W7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:b3gat3 ^@ http://purl.uniprot.org/uniprot/H2SIS1|||http://purl.uniprot.org/uniprot/Q5CB05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:LOC101067170 ^@ http://purl.uniprot.org/uniprot/H2SGJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/31033:rsad2 ^@ http://purl.uniprot.org/uniprot/H2S1T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RSAD2 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:cdk5 ^@ http://purl.uniprot.org/uniprot/H2SAY8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:LOC101068913 ^@ http://purl.uniprot.org/uniprot/H2SDH2 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/31033:LOC101080114 ^@ http://purl.uniprot.org/uniprot/A0A3B5KBQ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101062507 ^@ http://purl.uniprot.org/uniprot/H2S9D3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/31033:slc7a9 ^@ http://purl.uniprot.org/uniprot/H2RKJ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101079358 ^@ http://purl.uniprot.org/uniprot/A0A3B5KLI8 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101075548 ^@ http://purl.uniprot.org/uniprot/A0A6D2X9S2|||http://purl.uniprot.org/uniprot/H2T2X8 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:tnfsf10 ^@ http://purl.uniprot.org/uniprot/F8RC19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tumor necrosis factor family.|||Membrane|||Secreted http://togogenome.org/gene/31033:LOC101062799 ^@ http://purl.uniprot.org/uniprot/H2TGW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus|||Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation.|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101062541 ^@ http://purl.uniprot.org/uniprot/A0A3B5K1E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CART family.|||Secreted http://togogenome.org/gene/31033:cldn5c ^@ http://purl.uniprot.org/uniprot/Q6E5Q8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:LOC101071453 ^@ http://purl.uniprot.org/uniprot/H2UWJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/31033:LOC101065996 ^@ http://purl.uniprot.org/uniprot/H2U8M1 ^@ Similarity ^@ Belongs to the G-alpha family. G(s) subfamily. http://togogenome.org/gene/31033:foxd3 ^@ http://purl.uniprot.org/uniprot/A0A3B5K6M1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:ercc2 ^@ http://purl.uniprot.org/uniprot/H2T012 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RAD3/XPD subfamily.|||Nucleus http://togogenome.org/gene/31033:katnb1 ^@ http://purl.uniprot.org/uniprot/H2S9V8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat KATNB1 family.|||Cytoplasm|||Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome.|||Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/31033:mrpl37 ^@ http://purl.uniprot.org/uniprot/H2SG93 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/31033:rbbp4 ^@ http://purl.uniprot.org/uniprot/A0A674N6J1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:cav3 ^@ http://purl.uniprot.org/uniprot/A0A674NPA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/31033:LOC101075116 ^@ http://purl.uniprot.org/uniprot/A0A674MK96 ^@ Similarity ^@ Belongs to the lin-28 family. http://togogenome.org/gene/31033:mmd ^@ http://purl.uniprot.org/uniprot/A0A3B5KIC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/31033:tubg1 ^@ http://purl.uniprot.org/uniprot/H2ULC6 ^@ Function|||Similarity ^@ Belongs to the tubulin family.|||Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. http://togogenome.org/gene/31033:ap4m1 ^@ http://purl.uniprot.org/uniprot/A0A674MX47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal.|||Early endosome|||trans-Golgi network membrane http://togogenome.org/gene/31033:mrpl20 ^@ http://purl.uniprot.org/uniprot/A0A674P273 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family. http://togogenome.org/gene/31033:LOC101070764 ^@ http://purl.uniprot.org/uniprot/A0A674MCT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYRI family.|||Membrane http://togogenome.org/gene/31033:padi2 ^@ http://purl.uniprot.org/uniprot/A0A674PMQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/31033:agt ^@ http://purl.uniprot.org/uniprot/Q6IMN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family.|||Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.|||Secreted|||Stimulates aldosterone release. http://togogenome.org/gene/31033:nxt2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KFF4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/31033:fgf22 ^@ http://purl.uniprot.org/uniprot/A0A3B5K7I9 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/31033:LOC101062906 ^@ http://purl.uniprot.org/uniprot/H2SQ95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the argonaute family.|||P-body http://togogenome.org/gene/31033:slc12a2 ^@ http://purl.uniprot.org/uniprot/H2RWD1|||http://purl.uniprot.org/uniprot/H2RWD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/31033:sh3gl1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K5G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Membrane http://togogenome.org/gene/31033:dmrta1 ^@ http://purl.uniprot.org/uniprot/Q4AE29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||May be involved in sexual development.|||Nucleus http://togogenome.org/gene/31033:med24 ^@ http://purl.uniprot.org/uniprot/A0A3B5KCJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 24 family.|||Nucleus http://togogenome.org/gene/31033:rtn2 ^@ http://purl.uniprot.org/uniprot/Q4G5X4 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:cdh18 ^@ http://purl.uniprot.org/uniprot/A0A674MQU2 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/31033:trpv4 ^@ http://purl.uniprot.org/uniprot/A0A674PP79 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101073808 ^@ http://purl.uniprot.org/uniprot/H2SPK9 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/31033:LOC101079833 ^@ http://purl.uniprot.org/uniprot/H2USL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion.|||synaptosome http://togogenome.org/gene/31033:LOC101075171 ^@ http://purl.uniprot.org/uniprot/H2SCV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Nucleus http://togogenome.org/gene/31033:slc35c2 ^@ http://purl.uniprot.org/uniprot/A0A674NLU0|||http://purl.uniprot.org/uniprot/A0A674PDD1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:rfc2 ^@ http://purl.uniprot.org/uniprot/H2TJS8 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/31033:eif3a ^@ http://purl.uniprot.org/uniprot/H2V8Z7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit A family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Cytoplasm|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. http://togogenome.org/gene/31033:LOC101071876 ^@ http://purl.uniprot.org/uniprot/H2TW85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-alpha family. G(12) subfamily.|||Membrane http://togogenome.org/gene/31033:cdk2 ^@ http://purl.uniprot.org/uniprot/A0A674P2P3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:ttc39a ^@ http://purl.uniprot.org/uniprot/A0A674MUT4 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/31033:rps15 ^@ http://purl.uniprot.org/uniprot/A0A674PMU0 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS19 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/31033:LOC101062159 ^@ http://purl.uniprot.org/uniprot/A0A674NL27 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/31033:ctnna1 ^@ http://purl.uniprot.org/uniprot/H2TXI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||adherens junction http://togogenome.org/gene/31033:polr2j ^@ http://purl.uniprot.org/uniprot/A0A674NLW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.|||Nucleus http://togogenome.org/gene/31033:LOC101072250 ^@ http://purl.uniprot.org/uniprot/H2TWC4 ^@ Similarity ^@ Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. http://togogenome.org/gene/31033:tmed10 ^@ http://purl.uniprot.org/uniprot/A0A674MHS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:comt ^@ http://purl.uniprot.org/uniprot/H2UD96 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/31033:irf2 ^@ http://purl.uniprot.org/uniprot/H2RVT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Nucleus http://togogenome.org/gene/31033:nrg2 ^@ http://purl.uniprot.org/uniprot/H2V2Z6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neuregulin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/31033:nkx6-2 ^@ http://purl.uniprot.org/uniprot/H2TKI8 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:psmd12 ^@ http://purl.uniprot.org/uniprot/A0A3B5K381 ^@ Similarity ^@ Belongs to the proteasome subunit p55 family. http://togogenome.org/gene/31033:LOC101062038 ^@ http://purl.uniprot.org/uniprot/H2UBY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSG1 family.|||Membrane http://togogenome.org/gene/31033:tmem33 ^@ http://purl.uniprot.org/uniprot/A0A674PAH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/31033:ppa2 ^@ http://purl.uniprot.org/uniprot/A0A674NT77 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/31033:LOC101069787 ^@ http://purl.uniprot.org/uniprot/H2TUN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Engrailed homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:prkd2 ^@ http://purl.uniprot.org/uniprot/H2U720 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by DAG and phorbol esters.|||Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/31033:cfap298 ^@ http://purl.uniprot.org/uniprot/H2T0H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP298 family.|||cilium basal body http://togogenome.org/gene/31033:cutc ^@ http://purl.uniprot.org/uniprot/A0A3B5K3T0 ^@ Similarity ^@ Belongs to the CutC family. http://togogenome.org/gene/31033:LOC101066252 ^@ http://purl.uniprot.org/uniprot/H2UUF1 ^@ Similarity ^@ Belongs to the DIP2 family. http://togogenome.org/gene/31033:slc7a4 ^@ http://purl.uniprot.org/uniprot/H2STN9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101066738 ^@ http://purl.uniprot.org/uniprot/H2TWT4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:pnmt ^@ http://purl.uniprot.org/uniprot/H2U268 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. http://togogenome.org/gene/31033:ssu72 ^@ http://purl.uniprot.org/uniprot/A0A674MLZ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSU72 phosphatase family.|||Nucleus|||Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. http://togogenome.org/gene/31033:frrunt ^@ http://purl.uniprot.org/uniprot/A0A9P7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:slc35c1 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZ03|||http://purl.uniprot.org/uniprot/A0A3B5KC69 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:phyhipl ^@ http://purl.uniprot.org/uniprot/H2TBP2 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/31033:idh3b ^@ http://purl.uniprot.org/uniprot/A0A674NSD9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/31033:eif3i ^@ http://purl.uniprot.org/uniprot/H2TPH7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit I family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm http://togogenome.org/gene/31033:crebl2 ^@ http://purl.uniprot.org/uniprot/H2S5N3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. ATF subfamily.|||Nucleus http://togogenome.org/gene/31033:me3 ^@ http://purl.uniprot.org/uniprot/H2U396 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/31033:skp1 ^@ http://purl.uniprot.org/uniprot/H2T5K0 ^@ Function|||Similarity ^@ Belongs to the SKP1 family.|||Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. http://togogenome.org/gene/31033:tcea3 ^@ http://purl.uniprot.org/uniprot/H2UCQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/31033:LOC101069659 ^@ http://purl.uniprot.org/uniprot/H2S901 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/31033:LOC101072897 ^@ http://purl.uniprot.org/uniprot/H2V3T7 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/31033:pld3 ^@ http://purl.uniprot.org/uniprot/H2UXI9 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/31033:slc26a3 ^@ http://purl.uniprot.org/uniprot/A0A674NS55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.|||Membrane http://togogenome.org/gene/31033:LOC101065186 ^@ http://purl.uniprot.org/uniprot/A0A674MZB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/31033:cpsf7 ^@ http://purl.uniprot.org/uniprot/H2V519 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM CPSF6/7 family.|||Nucleus http://togogenome.org/gene/31033:LOC101065469 ^@ http://purl.uniprot.org/uniprot/A0A3B5KFK5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:atic ^@ http://purl.uniprot.org/uniprot/H2V3V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PurH family.|||cytosol http://togogenome.org/gene/31033:ruvbl1 ^@ http://purl.uniprot.org/uniprot/H2TNQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||Dynein axonemal particle|||Nucleus|||Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. http://togogenome.org/gene/31033:LOC101079525 ^@ http://purl.uniprot.org/uniprot/H2TQR4 ^@ Similarity ^@ Belongs to the teashirt C2H2-type zinc-finger protein family. http://togogenome.org/gene/31033:sf3b6 ^@ http://purl.uniprot.org/uniprot/A0A3B5JWG7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:zdhhc18 ^@ http://purl.uniprot.org/uniprot/H2UC29 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/31033:bmpr1b ^@ http://purl.uniprot.org/uniprot/H2S1K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/31033:LOC101072995 ^@ http://purl.uniprot.org/uniprot/A0A674P7D2 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/31033:foxd1 ^@ http://purl.uniprot.org/uniprot/H2VDS0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:anapc2 ^@ http://purl.uniprot.org/uniprot/H2S6S1 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/31033:LOC101070365 ^@ http://purl.uniprot.org/uniprot/D4AHP2 ^@ Similarity ^@ Belongs to the IL-17 family. http://togogenome.org/gene/31033:st3gal1 ^@ http://purl.uniprot.org/uniprot/Q702S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/31033:dimt1 ^@ http://purl.uniprot.org/uniprot/H2TCE0 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/31033:capn15 ^@ http://purl.uniprot.org/uniprot/A0A3B5KLM3|||http://purl.uniprot.org/uniprot/H2UHV7 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/31033:cpe ^@ http://purl.uniprot.org/uniprot/H2UTP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Membrane|||secretory vesicle membrane http://togogenome.org/gene/31033:LOC101072104 ^@ http://purl.uniprot.org/uniprot/A0A674PBA6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. http://togogenome.org/gene/31033:LOC101069617 ^@ http://purl.uniprot.org/uniprot/A0A674NPF7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 19 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/31033:txnl4b ^@ http://purl.uniprot.org/uniprot/A0A674NNA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/31033:mfsd5 ^@ http://purl.uniprot.org/uniprot/Q1KKV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Cell membrane|||Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum. http://togogenome.org/gene/31033:hmgcs1 ^@ http://purl.uniprot.org/uniprot/H2TS58 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/31033:LOC101061612 ^@ http://purl.uniprot.org/uniprot/H2RIS3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. http://togogenome.org/gene/31033:LOC105417139 ^@ http://purl.uniprot.org/uniprot/A0A674PRJ4 ^@ Similarity ^@ Belongs to the SYCE family. http://togogenome.org/gene/31033:LOC101075099 ^@ http://purl.uniprot.org/uniprot/H2UBD3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:slc35f6 ^@ http://purl.uniprot.org/uniprot/H2SWT3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLC35F solute transporter family.|||Interacts with SLC25A5.|||May play a role as a nucleotide-sugar transporter.|||Membrane|||Mitochondrion http://togogenome.org/gene/31033:dtwd2 ^@ http://purl.uniprot.org/uniprot/H2SK48 ^@ Similarity ^@ Belongs to the TDD superfamily. DTWD2 family. http://togogenome.org/gene/31033:LOC101072399 ^@ http://purl.uniprot.org/uniprot/H2RV36 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/31033:ndel1 ^@ http://purl.uniprot.org/uniprot/H2TPJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudE family.|||centrosome|||spindle http://togogenome.org/gene/31033:lsm5 ^@ http://purl.uniprot.org/uniprot/H2V8F9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. http://togogenome.org/gene/31033:acvr2b ^@ http://purl.uniprot.org/uniprot/A0A674NFV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/31033:nell1 ^@ http://purl.uniprot.org/uniprot/A0A674N9V0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101065179 ^@ http://purl.uniprot.org/uniprot/A0A674NZT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:slc27a1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K661 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/31033:LOC101064535 ^@ http://purl.uniprot.org/uniprot/A0A674NH25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the neuropeptide B/W family.|||Secreted http://togogenome.org/gene/31033:LOC101080220 ^@ http://purl.uniprot.org/uniprot/H2TS71 ^@ Function|||Similarity|||Subunit ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. http://togogenome.org/gene/31033:get3 ^@ http://purl.uniprot.org/uniprot/H2SVU0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.|||Belongs to the arsA ATPase family.|||Cytoplasm|||Endoplasmic reticulum|||Homodimer. http://togogenome.org/gene/31033:slc25a46 ^@ http://purl.uniprot.org/uniprot/A0A674NUZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/31033:kdm6a ^@ http://purl.uniprot.org/uniprot/A0A674MG93|||http://purl.uniprot.org/uniprot/A0A674P8U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTX family.|||Nucleus http://togogenome.org/gene/31033:LOC101079670 ^@ http://purl.uniprot.org/uniprot/A0A674P369 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily. http://togogenome.org/gene/31033:tpm1-2 ^@ http://purl.uniprot.org/uniprot/Q805C9|||http://purl.uniprot.org/uniprot/Q805D0|||http://purl.uniprot.org/uniprot/Q8JIM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/31033:mpv17l2 ^@ http://purl.uniprot.org/uniprot/H2SR57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/31033:LOC101066191 ^@ http://purl.uniprot.org/uniprot/H2TV36 ^@ Similarity ^@ Belongs to the RUNDC3 family. http://togogenome.org/gene/31033:cldn33b ^@ http://purl.uniprot.org/uniprot/Q6E5P3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:LOC101075438 ^@ http://purl.uniprot.org/uniprot/H2UCA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. http://togogenome.org/gene/31033:dbndd1 ^@ http://purl.uniprot.org/uniprot/H2VBI9 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/31033:zdhhc8 ^@ http://purl.uniprot.org/uniprot/Q2THV7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/31033:LOC101073004 ^@ http://purl.uniprot.org/uniprot/A0A674P7V5 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/31033:LOC101070310 ^@ http://purl.uniprot.org/uniprot/H2V154 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:banf1 ^@ http://purl.uniprot.org/uniprot/A0A674P9V4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:rab27a ^@ http://purl.uniprot.org/uniprot/H2V9S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/31033:gas8 ^@ http://purl.uniprot.org/uniprot/H2TEW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC4 family.|||flagellum|||flagellum axoneme http://togogenome.org/gene/31033:LOC101079967 ^@ http://purl.uniprot.org/uniprot/A0A3B5KJH4 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/31033:plcg1 ^@ http://purl.uniprot.org/uniprot/A0A674MB78 ^@ Function ^@ Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. http://togogenome.org/gene/31033:LOC101064537 ^@ http://purl.uniprot.org/uniprot/H2VCU0|||http://purl.uniprot.org/uniprot/Q6ZXZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/31033:esrra ^@ http://purl.uniprot.org/uniprot/H2RWY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/31033:LOC101075972 ^@ http://purl.uniprot.org/uniprot/H2SSW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/31033:LOC101077726 ^@ http://purl.uniprot.org/uniprot/H2V187 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/31033:ndrg2 ^@ http://purl.uniprot.org/uniprot/H2S287 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDRG family.|||Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.|||Cytoplasm http://togogenome.org/gene/31033:LOC101078322 ^@ http://purl.uniprot.org/uniprot/A0A674P8F5 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/31033:ska1 ^@ http://purl.uniprot.org/uniprot/H2V5G4 ^@ Similarity ^@ Belongs to the SKA1 family. http://togogenome.org/gene/31033:serpine3 ^@ http://purl.uniprot.org/uniprot/H2UBC7 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/31033:znf503 ^@ http://purl.uniprot.org/uniprot/H2S7B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Elbow/Noc family.|||Nucleus http://togogenome.org/gene/31033:LOC101067009 ^@ http://purl.uniprot.org/uniprot/A0A3B5K5R5 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:cd74 ^@ http://purl.uniprot.org/uniprot/H2SNE4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:yeats4 ^@ http://purl.uniprot.org/uniprot/H2UYR4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101079141 ^@ http://purl.uniprot.org/uniprot/A0A674MIF7 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Homodimer.|||Homodimerization via the leucine zipper domains is required for autophosphorylation. http://togogenome.org/gene/31033:septin8 ^@ http://purl.uniprot.org/uniprot/H2SRE6 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/31033:ddx18 ^@ http://purl.uniprot.org/uniprot/H2SML6 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/31033:paqr5 ^@ http://purl.uniprot.org/uniprot/H2V194 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/31033:cask ^@ http://purl.uniprot.org/uniprot/H2TXP5 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/31033:LOC101073067 ^@ http://purl.uniprot.org/uniprot/H2TZR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:tram1 ^@ http://purl.uniprot.org/uniprot/A0A674P126 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/31033:llgl2 ^@ http://purl.uniprot.org/uniprot/H2SZM3 ^@ Similarity ^@ Belongs to the WD repeat L(2)GL family. http://togogenome.org/gene/31033:LOC101061396 ^@ http://purl.uniprot.org/uniprot/A0A3B5KRU7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:LOC101071534 ^@ http://purl.uniprot.org/uniprot/H2TDD1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101065902 ^@ http://purl.uniprot.org/uniprot/A0A674PN87 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:LOC101072885 ^@ http://purl.uniprot.org/uniprot/P53480 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.|||Belongs to the actin family.|||In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.|||Monomethylation at Lys-86 (K86me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.|||N-terminal cleavage of acetylated cysteine of intermediate muscle actin by ACTMAP.|||Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.|||Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.|||Predominantly expressed in heart. Lower levels in skeletal muscle and skin.|||There are three genes coding for cardiac actin in Fugu.|||cytoskeleton http://togogenome.org/gene/31033:LOC101062124 ^@ http://purl.uniprot.org/uniprot/A0A674MAG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101072587 ^@ http://purl.uniprot.org/uniprot/H2V162 ^@ Function|||Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition. http://togogenome.org/gene/31033:LOC101063644 ^@ http://purl.uniprot.org/uniprot/A0A3B5JUE9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101064450 ^@ http://purl.uniprot.org/uniprot/H2V1I8 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/31033:LOC101069190 ^@ http://purl.uniprot.org/uniprot/H2V9W5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/31033:rdh10 ^@ http://purl.uniprot.org/uniprot/A0A674MEX5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/31033:mrs2 ^@ http://purl.uniprot.org/uniprot/H2TZ84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:cacfd1 ^@ http://purl.uniprot.org/uniprot/A0A674PL65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel flower family.|||Membrane http://togogenome.org/gene/31033:LOC101064834 ^@ http://purl.uniprot.org/uniprot/A0A674NJA5 ^@ Similarity ^@ Belongs to the paralemmin family. http://togogenome.org/gene/31033:lsm7 ^@ http://purl.uniprot.org/uniprot/A0A3B5K7X9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/31033:LOC101067574 ^@ http://purl.uniprot.org/uniprot/H2UZ46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/31033:smad1 ^@ http://purl.uniprot.org/uniprot/H2UI95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:nfic ^@ http://purl.uniprot.org/uniprot/H2SNH2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/31033:snd1 ^@ http://purl.uniprot.org/uniprot/Q6BCK4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. http://togogenome.org/gene/31033:LOC101064478 ^@ http://purl.uniprot.org/uniprot/A0A3B5K713 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/31033:mb ^@ http://purl.uniprot.org/uniprot/H2RIW6 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. http://togogenome.org/gene/31033:LOC101072541 ^@ http://purl.uniprot.org/uniprot/A0A674PGK4|||http://purl.uniprot.org/uniprot/Q1KKY1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC105418510 ^@ http://purl.uniprot.org/uniprot/A0A674P179 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/31033:cactin ^@ http://purl.uniprot.org/uniprot/H2SVY1 ^@ Similarity ^@ Belongs to the CACTIN family. http://togogenome.org/gene/31033:LOC101063508 ^@ http://purl.uniprot.org/uniprot/A0A674N148 ^@ Caution|||Similarity ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101069580 ^@ http://purl.uniprot.org/uniprot/A0A3B5KF41 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/31033:LOC101073692 ^@ http://purl.uniprot.org/uniprot/A0A674MG17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/31033:LOC101067686 ^@ http://purl.uniprot.org/uniprot/H2STK7 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/31033:ccr6 ^@ http://purl.uniprot.org/uniprot/G5EII2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:elf3 ^@ http://purl.uniprot.org/uniprot/A0A3B5KA01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/31033:LOC101069574 ^@ http://purl.uniprot.org/uniprot/A0A3B5K2S0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/31033:rras2 ^@ http://purl.uniprot.org/uniprot/A0A674P4P5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/31033:LOC101063560 ^@ http://purl.uniprot.org/uniprot/A0A674MPH9 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/31033:frg1 ^@ http://purl.uniprot.org/uniprot/O73747 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FRG1 family.|||Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B.|||Cajal body|||Cytoplasm|||Z line|||nucleolus http://togogenome.org/gene/31033:LOC101069822 ^@ http://purl.uniprot.org/uniprot/A0A3B5K2T3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/31033:LOC101072739 ^@ http://purl.uniprot.org/uniprot/Q2PR14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/31033:tert ^@ http://purl.uniprot.org/uniprot/H2UH84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reverse transcriptase family. Telomerase subfamily.|||Nucleus|||Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.|||telomere http://togogenome.org/gene/31033:chmp2a ^@ http://purl.uniprot.org/uniprot/H2TY84 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/31033:LOC101072119 ^@ http://purl.uniprot.org/uniprot/Q6E5Q0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:LOC101063872 ^@ http://purl.uniprot.org/uniprot/A0A3B5K7M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM53 family.|||Membrane|||Nucleus outer membrane http://togogenome.org/gene/31033:LOC101071700 ^@ http://purl.uniprot.org/uniprot/A0A674P398 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/31033:LOC101061156 ^@ http://purl.uniprot.org/uniprot/H2RN31 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/31033:LOC101069009 ^@ http://purl.uniprot.org/uniprot/A0A674P821 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/31033:gstk1 ^@ http://purl.uniprot.org/uniprot/H2ULE4 ^@ Similarity ^@ Belongs to the GST superfamily. Kappa family. http://togogenome.org/gene/31033:LOC101076802 ^@ http://purl.uniprot.org/uniprot/A0A674NDB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/31033:snap23 ^@ http://purl.uniprot.org/uniprot/A0A3B5KI43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||synaptosome http://togogenome.org/gene/31033:LOC101065200 ^@ http://purl.uniprot.org/uniprot/H2SEY8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ELO family. ELOVL4 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Oligomer. http://togogenome.org/gene/31033:spcs3 ^@ http://purl.uniprot.org/uniprot/H2SJ52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS3 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:edem1 ^@ http://purl.uniprot.org/uniprot/H2TV43 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/31033:LOC101073906 ^@ http://purl.uniprot.org/uniprot/A0A3B5KI81 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/31033:fzd4 ^@ http://purl.uniprot.org/uniprot/H2SSV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Membrane http://togogenome.org/gene/31033:LOC101077340 ^@ http://purl.uniprot.org/uniprot/A0A674MZ71 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:ubap2l ^@ http://purl.uniprot.org/uniprot/A0A674NJW8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:LOC101073277 ^@ http://purl.uniprot.org/uniprot/A0A674PE33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/31033:LOC101070754 ^@ http://purl.uniprot.org/uniprot/H2S4P0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/31033:trmt5 ^@ http://purl.uniprot.org/uniprot/H2TS57 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM5 / TYW2 family.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Mitochondrion matrix|||Monomer.|||Nucleus|||Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. http://togogenome.org/gene/31033:LOC101066992 ^@ http://purl.uniprot.org/uniprot/A0A674PGV2 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/31033:lfng ^@ http://purl.uniprot.org/uniprot/H2UGK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:kpna3 ^@ http://purl.uniprot.org/uniprot/H2UN31 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/31033:slc12a6 ^@ http://purl.uniprot.org/uniprot/H2S542 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/31033:ints8 ^@ http://purl.uniprot.org/uniprot/H2T146 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 8 family.|||Nucleus http://togogenome.org/gene/31033:nlgn2 ^@ http://purl.uniprot.org/uniprot/D2X2G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:fgf7 ^@ http://purl.uniprot.org/uniprot/A0A3B5KVZ3 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/31033:LOC101061919 ^@ http://purl.uniprot.org/uniprot/H2RQB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/31033:st6gal2 ^@ http://purl.uniprot.org/uniprot/Q5QQ37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Golgi stack membrane|||Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. http://togogenome.org/gene/31033:tpk1 ^@ http://purl.uniprot.org/uniprot/H2RLL1 ^@ Similarity ^@ Belongs to the thiamine pyrophosphokinase family. http://togogenome.org/gene/31033:tnfsf12 ^@ http://purl.uniprot.org/uniprot/A0A674NCA0 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/31033:mrps21 ^@ http://purl.uniprot.org/uniprot/A0A3B5K0G8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/31033:lrrn3 ^@ http://purl.uniprot.org/uniprot/H2SKI5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:cnot9 ^@ http://purl.uniprot.org/uniprot/H2SYI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT9 family.|||P-body http://togogenome.org/gene/31033:ackr3 ^@ http://purl.uniprot.org/uniprot/H2TRG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:b3gat2 ^@ http://purl.uniprot.org/uniprot/Q5CAZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:LOC101067792 ^@ http://purl.uniprot.org/uniprot/H2SFX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/31033:golt1b ^@ http://purl.uniprot.org/uniprot/A0A674PEC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/31033:g6pc ^@ http://purl.uniprot.org/uniprot/H2SVW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/31033:prph ^@ http://purl.uniprot.org/uniprot/H2VDL2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/31033:tdrd3 ^@ http://purl.uniprot.org/uniprot/H2V4B7 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1. http://togogenome.org/gene/31033:kdelr3 ^@ http://purl.uniprot.org/uniprot/A0A3B5KJQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:LOC101073605 ^@ http://purl.uniprot.org/uniprot/A0A674N6N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/31033:LOC100134850 ^@ http://purl.uniprot.org/uniprot/A8DPE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/31033:slc25a11 ^@ http://purl.uniprot.org/uniprot/A0A3B5KF06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:fam110b ^@ http://purl.uniprot.org/uniprot/H2T2C0 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/31033:LOC101070062 ^@ http://purl.uniprot.org/uniprot/A0A674N4F1 ^@ Similarity ^@ Belongs to the PICALM/SNAP91 family. http://togogenome.org/gene/31033:rhpn2 ^@ http://purl.uniprot.org/uniprot/A0A674PIX4 ^@ Similarity ^@ Belongs to the RHPN family. http://togogenome.org/gene/31033:LOC101079790 ^@ http://purl.uniprot.org/uniprot/H2V6I3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/31033:tafa3 ^@ http://purl.uniprot.org/uniprot/A0A3B5KC92 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/31033:prkcq ^@ http://purl.uniprot.org/uniprot/H2TZU4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. http://togogenome.org/gene/31033:tbca ^@ http://purl.uniprot.org/uniprot/H2VCA5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCA family.|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.|||Tubulin-folding protein; involved in the early step of the tubulin folding pathway.|||cytoskeleton http://togogenome.org/gene/31033:cldn15 ^@ http://purl.uniprot.org/uniprot/H2UQA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:LOC101075265 ^@ http://purl.uniprot.org/uniprot/A0A674NZA7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:tas1r1 ^@ http://purl.uniprot.org/uniprot/Q2MHK0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101072573 ^@ http://purl.uniprot.org/uniprot/H2U601|||http://purl.uniprot.org/uniprot/H2U603|||http://purl.uniprot.org/uniprot/H2U604 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101064940 ^@ http://purl.uniprot.org/uniprot/H2T574 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/31033:LOC101062877 ^@ http://purl.uniprot.org/uniprot/H2SG89 ^@ Activity Regulation|||Domain|||Function|||Subcellular Location Annotation ^@ Endosome membrane|||GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.|||GTPase-activating protein for the ADP ribosylation factor family.|||PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.|||The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions. http://togogenome.org/gene/31033:abcg4 ^@ http://purl.uniprot.org/uniprot/A0A674NH49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/31033:uii ^@ http://purl.uniprot.org/uniprot/Q2L4C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urotensin-2 family.|||Secreted http://togogenome.org/gene/31033:LOC101066223 ^@ http://purl.uniprot.org/uniprot/A0A3B5KK05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRH/QCR6 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:sbf2 ^@ http://purl.uniprot.org/uniprot/H2V622|||http://purl.uniprot.org/uniprot/H2V623 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/31033:LOC101063396 ^@ http://purl.uniprot.org/uniprot/A0A674MFV7 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/31033:LOC101076947 ^@ http://purl.uniprot.org/uniprot/A0A674PDQ0 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/31033:LOC101063580 ^@ http://purl.uniprot.org/uniprot/H2TZR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/31033:mpp1 ^@ http://purl.uniprot.org/uniprot/O57431 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/31033:cnr1 ^@ http://purl.uniprot.org/uniprot/Q98894 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for cannabinoids (By similarity). Mediates many cannabinoid-induced effects in the central nervous system (CNS), as well as in peripheral tissues (By similarity). Regulates cellular respiration and energy production in response to cannabinoids (By similarity). Signaling typically involves reduction in cyclic AMP (By similarity).|||Mitochondrion outer membrane|||Palmitoylation at Cys-414 is important for recruitment at both plasma membrane and lipid rafts and association with G protein alpha subunits.|||Presynapse|||axon http://togogenome.org/gene/31033:pfdn4 ^@ http://purl.uniprot.org/uniprot/H2T3G3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/31033:nek3 ^@ http://purl.uniprot.org/uniprot/H2UHD1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:LOC101078916 ^@ http://purl.uniprot.org/uniprot/A0A3B5KQB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/31033:LOC101080086 ^@ http://purl.uniprot.org/uniprot/A0A3B5K6W6 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/31033:pth2r ^@ http://purl.uniprot.org/uniprot/Q2UZQ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:isca2 ^@ http://purl.uniprot.org/uniprot/A0A674NQQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/31033:LOC101067179 ^@ http://purl.uniprot.org/uniprot/A0A674P9F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.|||Cytoplasm http://togogenome.org/gene/31033:vps53 ^@ http://purl.uniprot.org/uniprot/A0A3B5K7J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS53 family.|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/31033:timm13 ^@ http://purl.uniprot.org/uniprot/A0A674PI64 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/31033:rnf152 ^@ http://purl.uniprot.org/uniprot/H2V8I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNF152 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/31033:slc7a11 ^@ http://purl.uniprot.org/uniprot/A0A674PDG1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101070215 ^@ http://purl.uniprot.org/uniprot/Q1KL24 ^@ Similarity ^@ Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily. http://togogenome.org/gene/31033:fam20a ^@ http://purl.uniprot.org/uniprot/A0A6D2Y359|||http://purl.uniprot.org/uniprot/H2V074 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/31033:polr3k ^@ http://purl.uniprot.org/uniprot/H2TZ33 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/31033:LOC101071060 ^@ http://purl.uniprot.org/uniprot/H2T2C5 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/31033:nek8 ^@ http://purl.uniprot.org/uniprot/H2SLW6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. http://togogenome.org/gene/31033:LOC101063947 ^@ http://purl.uniprot.org/uniprot/A0A3B5JU99 ^@ Function|||Subcellular Location Annotation ^@ Endomembrane system|||Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. http://togogenome.org/gene/31033:LOC101071585 ^@ http://purl.uniprot.org/uniprot/H2SY39 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/31033:melk ^@ http://purl.uniprot.org/uniprot/H2SD98 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/31033:LOC101069556 ^@ http://purl.uniprot.org/uniprot/H2TTH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/31033:brix1 ^@ http://purl.uniprot.org/uniprot/H2TVU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BRX1 family.|||Required for biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/31033:ccdc22 ^@ http://purl.uniprot.org/uniprot/H2RV50 ^@ Similarity ^@ Belongs to the CCDC22 family. http://togogenome.org/gene/31033:qki ^@ http://purl.uniprot.org/uniprot/H2U0Y4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/31033:rce1 ^@ http://purl.uniprot.org/uniprot/H2S941 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase U48 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:LOC101066100 ^@ http://purl.uniprot.org/uniprot/H2UIV5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/31033:LOC100462937 ^@ http://purl.uniprot.org/uniprot/A0A674PGU8 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/31033:LOC101069583 ^@ http://purl.uniprot.org/uniprot/H2UKF0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:ndufa7 ^@ http://purl.uniprot.org/uniprot/A0A674M8Q6 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA7 subunit family.|||Complex I is composed of 45 different subunits. http://togogenome.org/gene/31033:psmb3 ^@ http://purl.uniprot.org/uniprot/A0A3B5KAB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:LOC101077479 ^@ http://purl.uniprot.org/uniprot/H2UGI1 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/31033:LOC101071974 ^@ http://purl.uniprot.org/uniprot/A0A674NV17 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/31033:ifrd1 ^@ http://purl.uniprot.org/uniprot/H2S0Y8 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/31033:LOC101077776 ^@ http://purl.uniprot.org/uniprot/H2T950 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101075569 ^@ http://purl.uniprot.org/uniprot/H2RRP3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. http://togogenome.org/gene/31033:rab9a ^@ http://purl.uniprot.org/uniprot/H2TAZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||phagosome membrane http://togogenome.org/gene/31033:vps37b ^@ http://purl.uniprot.org/uniprot/A0A3B5K2L7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/31033:LOC101074400 ^@ http://purl.uniprot.org/uniprot/H2UXZ1 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/31033:LOC101063611 ^@ http://purl.uniprot.org/uniprot/H2SM81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/31033:LOC101061742 ^@ http://purl.uniprot.org/uniprot/H2U2P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/31033:wdr91 ^@ http://purl.uniprot.org/uniprot/A0A674MX99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR91 family.|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/31033:rpl22l1 ^@ http://purl.uniprot.org/uniprot/H2S4R5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/31033:LOC101075774 ^@ http://purl.uniprot.org/uniprot/A0A3B5K6W9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Nucleus|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/31033:atp8a1 ^@ http://purl.uniprot.org/uniprot/A0A674N6L3|||http://purl.uniprot.org/uniprot/H2UEP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/31033:psmc3 ^@ http://purl.uniprot.org/uniprot/H2T0R7 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/31033:ppil1 ^@ http://purl.uniprot.org/uniprot/H2UNQ9 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/31033:nop16 ^@ http://purl.uniprot.org/uniprot/A0A3B5KFW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP16 family.|||nucleolus http://togogenome.org/gene/31033:LOC101077175 ^@ http://purl.uniprot.org/uniprot/H2SHP1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/31033:prlr ^@ http://purl.uniprot.org/uniprot/Q1HAY8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Membrane|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation.|||This is a receptor for the anterior pituitary hormone prolactin. http://togogenome.org/gene/31033:LOC101079202 ^@ http://purl.uniprot.org/uniprot/A0A674NGL5 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/31033:LOC105419818 ^@ http://purl.uniprot.org/uniprot/H2RUY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:pofut2 ^@ http://purl.uniprot.org/uniprot/A0A3B5K6P6 ^@ Similarity ^@ Belongs to the glycosyltransferase 68 family. http://togogenome.org/gene/31033:LOC101069559 ^@ http://purl.uniprot.org/uniprot/H2SJ42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/31033:LOC101078653 ^@ http://purl.uniprot.org/uniprot/A0A674P681 ^@ Similarity|||Subunit ^@ Belongs to the 14-3-3 family.|||Homodimer, and heterodimer with other family members. http://togogenome.org/gene/31033:emp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KP35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/31033:arsb ^@ http://purl.uniprot.org/uniprot/H2S6H5 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/31033:gdpd2 ^@ http://purl.uniprot.org/uniprot/H2TH64 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/31033:LOC101064870 ^@ http://purl.uniprot.org/uniprot/H2UA29 ^@ Similarity ^@ Belongs to the requiem/DPF family. http://togogenome.org/gene/31033:cxcl12 ^@ http://purl.uniprot.org/uniprot/A0A674NL48 ^@ Similarity ^@ Belongs to the intercrine alpha (chemokine CxC) family. http://togogenome.org/gene/31033:golph3 ^@ http://purl.uniprot.org/uniprot/A0A674PPZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Golgi stack membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/31033:tnfsf13b ^@ http://purl.uniprot.org/uniprot/A0A3B5JW09 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/31033:LOC101079316 ^@ http://purl.uniprot.org/uniprot/A0A3B5KJU1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101064528 ^@ http://purl.uniprot.org/uniprot/H2THQ2 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/31033:grb14 ^@ http://purl.uniprot.org/uniprot/H2RPN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101076653 ^@ http://purl.uniprot.org/uniprot/H2UW36 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/31033:slc52a2 ^@ http://purl.uniprot.org/uniprot/H2S3Z9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/31033:ccna1 ^@ http://purl.uniprot.org/uniprot/A0A674ME32 ^@ Function|||Similarity|||Subunit ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. http://togogenome.org/gene/31033:arpc5 ^@ http://purl.uniprot.org/uniprot/A0A674MHW7 ^@ Function|||Similarity ^@ Belongs to the ARPC5 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. http://togogenome.org/gene/31033:stx10 ^@ http://purl.uniprot.org/uniprot/A0A3B5K5W3 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane http://togogenome.org/gene/31033:LOC101063412 ^@ http://purl.uniprot.org/uniprot/H2UGG7 ^@ Function|||Similarity ^@ Belongs to the PET191 family.|||Involved in an early step of the mitochondrial complex IV assembly process. http://togogenome.org/gene/31033:insm1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K3B2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:rsl24d1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KIB9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/31033:tacr2 ^@ http://purl.uniprot.org/uniprot/H2S9N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:med17 ^@ http://purl.uniprot.org/uniprot/H2SCK9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 17 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/31033:cep55 ^@ http://purl.uniprot.org/uniprot/H2TSC5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:snx33 ^@ http://purl.uniprot.org/uniprot/H2UW34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/31033:gk ^@ http://purl.uniprot.org/uniprot/H2U3D8|||http://purl.uniprot.org/uniprot/H2U3D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FGGY kinase family.|||Cytoplasm http://togogenome.org/gene/31033:npy2r ^@ http://purl.uniprot.org/uniprot/A7XY83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101072932 ^@ http://purl.uniprot.org/uniprot/H2V020 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:LOC101067694 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZF7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/31033:zfhx4 ^@ http://purl.uniprot.org/uniprot/H2RJP5 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:map2k1 ^@ http://purl.uniprot.org/uniprot/A0A674P793 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:tbx15 ^@ http://purl.uniprot.org/uniprot/H2SAB5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/31033:LOC101068736 ^@ http://purl.uniprot.org/uniprot/H2UYT2 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/31033:tppp ^@ http://purl.uniprot.org/uniprot/A0A674MS92 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/31033:plod3 ^@ http://purl.uniprot.org/uniprot/A5A6S2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/31033:timm10 ^@ http://purl.uniprot.org/uniprot/H2ULG2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/31033:gtf2h1 ^@ http://purl.uniprot.org/uniprot/H2TDV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB1 family.|||Nucleus http://togogenome.org/gene/31033:adprhl1 ^@ http://purl.uniprot.org/uniprot/H2V4H9 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/31033:LOC101074350 ^@ http://purl.uniprot.org/uniprot/A0A674PKX6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/31033:neu3 ^@ http://purl.uniprot.org/uniprot/A7TVK4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/31033:dennd11 ^@ http://purl.uniprot.org/uniprot/A0A3B5KNA8 ^@ Similarity ^@ Belongs to the DENND11 family. http://togogenome.org/gene/31033:pnpla4 ^@ http://purl.uniprot.org/uniprot/A0A674NSG8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:ppp2cb ^@ http://purl.uniprot.org/uniprot/H2TU36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101064309 ^@ http://purl.uniprot.org/uniprot/A0A3B5KJB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/31033:LOC101062951 ^@ http://purl.uniprot.org/uniprot/A0A3B5KLB5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:snapc3 ^@ http://purl.uniprot.org/uniprot/H2TJN2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAPC3/SRD2 family.|||Nucleus|||Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.|||Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. http://togogenome.org/gene/31033:cmtr1 ^@ http://purl.uniprot.org/uniprot/H2ULE6 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).|||S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. http://togogenome.org/gene/31033:ndufa1 ^@ http://purl.uniprot.org/uniprot/H2TQ99 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA1 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:npc1l1 ^@ http://purl.uniprot.org/uniprot/H2SIS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/31033:fxn ^@ http://purl.uniprot.org/uniprot/A0A3B5KW58 ^@ Similarity ^@ Belongs to the frataxin family. http://togogenome.org/gene/31033:srsf1 ^@ http://purl.uniprot.org/uniprot/H2S8C5 ^@ Similarity ^@ Belongs to the splicing factor SR family. http://togogenome.org/gene/31033:LOC101062328 ^@ http://purl.uniprot.org/uniprot/A0A3B5KKG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin basic protein family.|||Myelin membrane http://togogenome.org/gene/31033:med7 ^@ http://purl.uniprot.org/uniprot/A0A674NSV7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 7 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/31033:pnpt1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K500 ^@ Similarity ^@ Belongs to the polyribonucleotide nucleotidyltransferase family. http://togogenome.org/gene/31033:ptpn4 ^@ http://purl.uniprot.org/uniprot/A0A674PBS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/31033:LOC101074215 ^@ http://purl.uniprot.org/uniprot/H2SW69 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/31033:yipf4 ^@ http://purl.uniprot.org/uniprot/H2RV53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:atp5f1a ^@ http://purl.uniprot.org/uniprot/A0A3B5K2L0 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/31033:lin7c ^@ http://purl.uniprot.org/uniprot/A0A674NGI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-7 family.|||Cell junction|||Cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. http://togogenome.org/gene/31033:fam92a ^@ http://purl.uniprot.org/uniprot/A0A674PK98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CIBAR family.|||centriole http://togogenome.org/gene/31033:slc17a5 ^@ http://purl.uniprot.org/uniprot/A0A674NKY2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:raf1 ^@ http://purl.uniprot.org/uniprot/A0A6D2XWC0|||http://purl.uniprot.org/uniprot/Q5NSW0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/31033:tmem181 ^@ http://purl.uniprot.org/uniprot/A0A674MDH4|||http://purl.uniprot.org/uniprot/A0A674MPS2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101078882 ^@ http://purl.uniprot.org/uniprot/H2SJI9 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/31033:LOC101066693 ^@ http://purl.uniprot.org/uniprot/Q802A3 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/31033:ephb3 ^@ http://purl.uniprot.org/uniprot/H2SYD0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:slc35e1 ^@ http://purl.uniprot.org/uniprot/H2SWN1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:homer2 ^@ http://purl.uniprot.org/uniprot/H2V3M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/31033:creld1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KI01 ^@ Caution|||Similarity ^@ Belongs to the CRELD family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:eif4enif1 ^@ http://purl.uniprot.org/uniprot/H2UQ73 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:cldn7 ^@ http://purl.uniprot.org/uniprot/A0A3B5KDQ0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:LOC101080202 ^@ http://purl.uniprot.org/uniprot/H2SLJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/31033:slc39a9 ^@ http://purl.uniprot.org/uniprot/A0A3B5K8G6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Cell membrane|||Membrane|||Mitochondrion|||Nucleus|||Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.|||perinuclear region|||trans-Golgi network membrane http://togogenome.org/gene/31033:cluh ^@ http://purl.uniprot.org/uniprot/H2UU85 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CLU family.|||Cytoplasm|||Cytoplasmic granule|||mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis. http://togogenome.org/gene/31033:LOC101062032 ^@ http://purl.uniprot.org/uniprot/A0A674MGR7 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:actl6a ^@ http://purl.uniprot.org/uniprot/A0A674MLM2 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/31033:pdrg1 ^@ http://purl.uniprot.org/uniprot/A0A674MGW1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.|||Cytoplasm|||May play a role in chaperone-mediated protein folding. http://togogenome.org/gene/31033:hint1 ^@ http://purl.uniprot.org/uniprot/H2TJM3 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/31033:enkur ^@ http://purl.uniprot.org/uniprot/H2TFA1 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/31033:itga11 ^@ http://purl.uniprot.org/uniprot/H2V0X6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/31033:rps21 ^@ http://purl.uniprot.org/uniprot/H2RKP1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS21 family.|||Component of the 40S small ribosomal subunit.|||Endoplasmic reticulum|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/31033:slc2a9 ^@ http://purl.uniprot.org/uniprot/A0A674N1C7 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/31033:pcyt1b ^@ http://purl.uniprot.org/uniprot/A0A674PMD5 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/31033:cab39 ^@ http://purl.uniprot.org/uniprot/H2STL7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/31033:fam168a ^@ http://purl.uniprot.org/uniprot/H2SWN8 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/31033:scnm1 ^@ http://purl.uniprot.org/uniprot/H2RQA3 ^@ Subcellular Location Annotation ^@ Nucleus speckle|||nucleoplasm http://togogenome.org/gene/31033:LOC101075980 ^@ http://purl.uniprot.org/uniprot/H2RN87 ^@ Similarity ^@ Belongs to the JAKMIP family. http://togogenome.org/gene/31033:LOC446001 ^@ http://purl.uniprot.org/uniprot/Q7T1U3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:LOC101069808 ^@ http://purl.uniprot.org/uniprot/H2SYN5 ^@ Similarity ^@ Belongs to the ataxin-2 family. http://togogenome.org/gene/31033:LOC101074415 ^@ http://purl.uniprot.org/uniprot/H2V1R1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:nudt19 ^@ http://purl.uniprot.org/uniprot/H2RKH3 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/31033:LOC101065875 ^@ http://purl.uniprot.org/uniprot/A0A674PLM8 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/31033:LOC101079985 ^@ http://purl.uniprot.org/uniprot/A0A674N7J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:LOC105416482 ^@ http://purl.uniprot.org/uniprot/A0A3B5KG64 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/31033:ak6 ^@ http://purl.uniprot.org/uniprot/H2S4U4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.|||Cajal body|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer and homodimer. Interacts with COIL (via C-terminus).|||nucleoplasm http://togogenome.org/gene/31033:LOC101063891 ^@ http://purl.uniprot.org/uniprot/A0A674NMC7 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/31033:hoxa3 ^@ http://purl.uniprot.org/uniprot/Q1KL12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:atg12 ^@ http://purl.uniprot.org/uniprot/A0A674P1N5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATG12 family.|||Forms a conjugate with ATG5.|||Ubiquitin-like protein involved in autophagic vesicle formation. http://togogenome.org/gene/31033:LOC101063915 ^@ http://purl.uniprot.org/uniprot/A0A674NQM9|||http://purl.uniprot.org/uniprot/H2TT26 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/31033:ngrn ^@ http://purl.uniprot.org/uniprot/H2SAJ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neugrin family.|||Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.|||Mitochondrion membrane|||Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system. http://togogenome.org/gene/31033:LOC101072736 ^@ http://purl.uniprot.org/uniprot/A0A3B5JV66 ^@ Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Lipid droplet http://togogenome.org/gene/31033:LOC101078369 ^@ http://purl.uniprot.org/uniprot/A0A674MZZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:tex261 ^@ http://purl.uniprot.org/uniprot/A0A3B5JXT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVP26 family.|||Membrane http://togogenome.org/gene/31033:gpr161 ^@ http://purl.uniprot.org/uniprot/A0A3B5K5C1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:LOC101068552 ^@ http://purl.uniprot.org/uniprot/A0A674N9G5 ^@ Similarity ^@ Belongs to the IL-17 family. http://togogenome.org/gene/31033:pde6d ^@ http://purl.uniprot.org/uniprot/A0A3B5K321 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PDE6D/unc-119 family.|||Cytoplasmic vesicle membrane|||Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.|||Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.|||cilium basal body|||cytosol http://togogenome.org/gene/31033:dennd5a ^@ http://purl.uniprot.org/uniprot/H2V5X9 ^@ Caution|||Similarity ^@ Belongs to the RAB6IP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:aasdhppt ^@ http://purl.uniprot.org/uniprot/H2T654 ^@ Similarity ^@ Belongs to the P-Pant transferase superfamily. AcpS family. http://togogenome.org/gene/31033:LOC101069964 ^@ http://purl.uniprot.org/uniprot/A0A674PNC2 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/31033:hebp1 ^@ http://purl.uniprot.org/uniprot/H2SQV5 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/31033:grpr ^@ http://purl.uniprot.org/uniprot/H2V352 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101080028 ^@ http://purl.uniprot.org/uniprot/A0A3B5K8T7 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/31033:hras ^@ http://purl.uniprot.org/uniprot/A0A3B5KFE1 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/31033:ap1g1 ^@ http://purl.uniprot.org/uniprot/H2V7V8 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/31033:LOC101079400 ^@ http://purl.uniprot.org/uniprot/A0A3B5KQN5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:dvl1 ^@ http://purl.uniprot.org/uniprot/A0A674PEK1 ^@ Similarity ^@ Belongs to the DSH family. http://togogenome.org/gene/31033:serpine2 ^@ http://purl.uniprot.org/uniprot/H2TQ93 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/31033:ssr2 ^@ http://purl.uniprot.org/uniprot/H2UIQ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-beta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/31033:LOC101077225 ^@ http://purl.uniprot.org/uniprot/A0A674PC53 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/31033:bysl ^@ http://purl.uniprot.org/uniprot/H2TCZ2 ^@ Similarity ^@ Belongs to the bystin family. http://togogenome.org/gene/31033:lhx5 ^@ http://purl.uniprot.org/uniprot/H2VCV9 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:hoxb5 ^@ http://purl.uniprot.org/uniprot/Q1KKX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101080063 ^@ http://purl.uniprot.org/uniprot/H2US44 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/31033:LOC101061481 ^@ http://purl.uniprot.org/uniprot/Q1KKY4 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101062393 ^@ http://purl.uniprot.org/uniprot/H2SLN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Membrane|||Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity. http://togogenome.org/gene/31033:atp2c1 ^@ http://purl.uniprot.org/uniprot/H2TYR3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:sfmbt1 ^@ http://purl.uniprot.org/uniprot/H2SDN0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:nthl1 ^@ http://purl.uniprot.org/uniprot/A0A674PQW9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Nth/MutY family.|||Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.|||Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.|||Mitochondrion|||Nucleus http://togogenome.org/gene/31033:LOC101071455 ^@ http://purl.uniprot.org/uniprot/H2UI82 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/31033:tmem98 ^@ http://purl.uniprot.org/uniprot/H2UZU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM98 family.|||Endoplasmic reticulum membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/31033:LOC101074340 ^@ http://purl.uniprot.org/uniprot/H2RJC4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:tjap1 ^@ http://purl.uniprot.org/uniprot/H2S4M0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:chmp6 ^@ http://purl.uniprot.org/uniprot/A0A3B5K7Y1 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/31033:pole ^@ http://purl.uniprot.org/uniprot/A0A3B5KBV2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||DNA polymerase II participates in chromosomal DNA replication.|||Nucleus http://togogenome.org/gene/31033:LOC101064057 ^@ http://purl.uniprot.org/uniprot/A0A674NIL6 ^@ Caution|||Similarity ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:nrp2 ^@ http://purl.uniprot.org/uniprot/A0A674NN94 ^@ Caution|||Similarity ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101069201 ^@ http://purl.uniprot.org/uniprot/A0A674MQ65 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/31033:LOC101073057 ^@ http://purl.uniprot.org/uniprot/H2TZH1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:nup155 ^@ http://purl.uniprot.org/uniprot/Q9DD34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the non-repetitive/WGA-negative nucleoporin family.|||nuclear pore complex http://togogenome.org/gene/31033:lrp10 ^@ http://purl.uniprot.org/uniprot/A0A3B5K479 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:aif1l ^@ http://purl.uniprot.org/uniprot/A0A3B5KL03 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/31033:LOC101068225 ^@ http://purl.uniprot.org/uniprot/H2UHB6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/31033:LOC101067231 ^@ http://purl.uniprot.org/uniprot/A0A3B5KB47 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/31033:pign ^@ http://purl.uniprot.org/uniprot/H2RK50 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.|||Endoplasmic reticulum membrane|||Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.|||Membrane http://togogenome.org/gene/31033:LOC105417034 ^@ http://purl.uniprot.org/uniprot/H2RK83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/31033:xpa ^@ http://purl.uniprot.org/uniprot/H2UR40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPA family.|||Nucleus http://togogenome.org/gene/31033:LOC101068320 ^@ http://purl.uniprot.org/uniprot/H2S9I2 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/31033:LOC101079880 ^@ http://purl.uniprot.org/uniprot/A0A3B5KMF9 ^@ Caution|||Similarity ^@ Belongs to the LDLR family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:crbn ^@ http://purl.uniprot.org/uniprot/A0A3B5KIU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRBN family.|||Nucleus http://togogenome.org/gene/31033:LOC101068421 ^@ http://purl.uniprot.org/uniprot/H2UDA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/31033:rars2 ^@ http://purl.uniprot.org/uniprot/H2V8R5 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/31033:LOC101069880 ^@ http://purl.uniprot.org/uniprot/H2TDT0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/31033:LOC101076782 ^@ http://purl.uniprot.org/uniprot/H2VE76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:slc25a42 ^@ http://purl.uniprot.org/uniprot/A0A3B5K3W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:fghce ^@ http://purl.uniprot.org/uniprot/Q2PED7 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:rora ^@ http://purl.uniprot.org/uniprot/A0A674NZT1|||http://purl.uniprot.org/uniprot/H2TPM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/31033:iah1 ^@ http://purl.uniprot.org/uniprot/A0A674P2I5 ^@ Function|||Similarity ^@ Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.|||Probable lipase. http://togogenome.org/gene/31033:mtmr7 ^@ http://purl.uniprot.org/uniprot/H2T8F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/31033:ss18 ^@ http://purl.uniprot.org/uniprot/H2TD73|||http://purl.uniprot.org/uniprot/H2TD74 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/31033:rrad ^@ http://purl.uniprot.org/uniprot/H2V4P1 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/31033:LOC101068534 ^@ http://purl.uniprot.org/uniprot/H2UIK1 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/31033:micos13 ^@ http://purl.uniprot.org/uniprot/A0A3B5KD43 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic13 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/31033:ube2a ^@ http://purl.uniprot.org/uniprot/A0A674PRE2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/31033:LOC101063278 ^@ http://purl.uniprot.org/uniprot/A0A674P6F0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:cops7a ^@ http://purl.uniprot.org/uniprot/H2TSC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:LOC101067122 ^@ http://purl.uniprot.org/uniprot/H2UH43 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/31033:LOC101078425 ^@ http://purl.uniprot.org/uniprot/A0A3B5K976 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:septin10 ^@ http://purl.uniprot.org/uniprot/A0A674NLV8 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/31033:gins4 ^@ http://purl.uniprot.org/uniprot/H2S4A2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS4/SLD5 family.|||Chromosome|||Nucleus|||Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/31033:syf2 ^@ http://purl.uniprot.org/uniprot/H2RTI5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYF2 family.|||Involved in pre-mRNA splicing.|||May be part of a spliceosome complex.|||Nucleus http://togogenome.org/gene/31033:LOC101070704 ^@ http://purl.uniprot.org/uniprot/A0A674NE11 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/31033:LOC101067091 ^@ http://purl.uniprot.org/uniprot/H2UFT0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101068908 ^@ http://purl.uniprot.org/uniprot/H2UEB2 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/31033:ppara2 ^@ http://purl.uniprot.org/uniprot/A4PE12|||http://purl.uniprot.org/uniprot/H2SPP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/31033:LOC101063304 ^@ http://purl.uniprot.org/uniprot/H2VDW0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:sncb ^@ http://purl.uniprot.org/uniprot/Q3LU30 ^@ Similarity ^@ Belongs to the synuclein family. http://togogenome.org/gene/31033:LOC101061669 ^@ http://purl.uniprot.org/uniprot/H2V8W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM59 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:LOC101067614 ^@ http://purl.uniprot.org/uniprot/H2SH38 ^@ Function|||Similarity|||Subunit ^@ Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.|||Belongs to the fucolectin family.|||Homotrimer. http://togogenome.org/gene/31033:lingo3 ^@ http://purl.uniprot.org/uniprot/A0A674PNP4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:katna1 ^@ http://purl.uniprot.org/uniprot/H2SWN0 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.|||Cytoplasm|||centrosome|||spindle|||spindle pole http://togogenome.org/gene/31033:cat ^@ http://purl.uniprot.org/uniprot/A0A6D2XID5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the catalase family.|||Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.|||Peroxisome http://togogenome.org/gene/31033:LOC101068135 ^@ http://purl.uniprot.org/uniprot/A0A674M9V1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:psme3 ^@ http://purl.uniprot.org/uniprot/A0A674NT88 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/31033:nxph2 ^@ http://purl.uniprot.org/uniprot/H2T7P5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/31033:pdpr ^@ http://purl.uniprot.org/uniprot/A0A674MYH2 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/31033:mea1 ^@ http://purl.uniprot.org/uniprot/H2S1U0 ^@ Function ^@ May play an important role in spermatogenesis and/or testis development. http://togogenome.org/gene/31033:fut9c ^@ http://purl.uniprot.org/uniprot/Q70AG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/31033:ptdss2 ^@ http://purl.uniprot.org/uniprot/H2UX69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphatidyl serine synthase family.|||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:slc25a15 ^@ http://purl.uniprot.org/uniprot/A0A3B5K1Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:LOC101071471 ^@ http://purl.uniprot.org/uniprot/A0A3B5JWB8|||http://purl.uniprot.org/uniprot/A0A3B5KG23 ^@ Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family. http://togogenome.org/gene/31033:b4gat1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K8M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 49 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:LOC101073405 ^@ http://purl.uniprot.org/uniprot/H2UR30 ^@ Similarity ^@ Belongs to the vasopressin/oxytocin family. http://togogenome.org/gene/31033:LOC101070289 ^@ http://purl.uniprot.org/uniprot/A0A173MSG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/31033:mrps25 ^@ http://purl.uniprot.org/uniprot/H2TX09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS25 family.|||Mitochondrion http://togogenome.org/gene/31033:LOC101062935 ^@ http://purl.uniprot.org/uniprot/A0A674NTM6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/31033:LOC101065122 ^@ http://purl.uniprot.org/uniprot/H2TS63 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/31033:LOC101064797 ^@ http://purl.uniprot.org/uniprot/H2V9T0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:nosip ^@ http://purl.uniprot.org/uniprot/H2TIP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOSIP family.|||Cytoplasm|||Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity.|||Nucleus http://togogenome.org/gene/31033:LOC101069540 ^@ http://purl.uniprot.org/uniprot/A0A674NL63 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular space http://togogenome.org/gene/31033:LOC101076469 ^@ http://purl.uniprot.org/uniprot/H2SH61 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:LOC101068879 ^@ http://purl.uniprot.org/uniprot/A0A674MWD0 ^@ Similarity ^@ Belongs to the PAIP2 family. http://togogenome.org/gene/31033:dio3 ^@ http://purl.uniprot.org/uniprot/B1B572 ^@ Function|||Similarity ^@ Belongs to the iodothyronine deiodinase family.|||Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine). http://togogenome.org/gene/31033:eif2s2 ^@ http://purl.uniprot.org/uniprot/A0A3B5K6A8 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/31033:LOC101078762 ^@ http://purl.uniprot.org/uniprot/H2UJR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphatidyl serine synthase family.|||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:bcl7b ^@ http://purl.uniprot.org/uniprot/A0A3B5JZI1 ^@ Similarity ^@ Belongs to the BCL7 family. http://togogenome.org/gene/31033:cdkl1 ^@ http://purl.uniprot.org/uniprot/H2THF7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:hoxd10 ^@ http://purl.uniprot.org/uniprot/H2V6U0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101064659 ^@ http://purl.uniprot.org/uniprot/H2RJJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family.|||Cytoplasm http://togogenome.org/gene/31033:mmp13 ^@ http://purl.uniprot.org/uniprot/H2S9U1 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/31033:LOC101063736 ^@ http://purl.uniprot.org/uniprot/A0A674NX23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/31033:LOC101066426 ^@ http://purl.uniprot.org/uniprot/H2SJP4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:LOC101072094 ^@ http://purl.uniprot.org/uniprot/H2SJV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/31033:hmbs ^@ http://purl.uniprot.org/uniprot/A0A674PK14|||http://purl.uniprot.org/uniprot/H2TLD4 ^@ Similarity ^@ Belongs to the HMBS family. http://togogenome.org/gene/31033:tm2d2 ^@ http://purl.uniprot.org/uniprot/H2V040 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:usp44 ^@ http://purl.uniprot.org/uniprot/A0A3B5KGU8 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/31033:LOC101080060 ^@ http://purl.uniprot.org/uniprot/A0A674MLX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CART family.|||Secreted http://togogenome.org/gene/31033:LOC101063506 ^@ http://purl.uniprot.org/uniprot/H2T6F9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101062968 ^@ http://purl.uniprot.org/uniprot/A0A674NKX7 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/31033:nlk ^@ http://purl.uniprot.org/uniprot/Q9I863 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/31033:arpc2 ^@ http://purl.uniprot.org/uniprot/H2UIU6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC2 family.|||Cell projection|||Component of the Arp2/3 complex.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/31033:LOC101066220 ^@ http://purl.uniprot.org/uniprot/A0A3B5K127 ^@ Subcellular Location Annotation ^@ Mitochondrion intermembrane space http://togogenome.org/gene/31033:cdv3 ^@ http://purl.uniprot.org/uniprot/H2STJ3 ^@ Similarity ^@ Belongs to the CDV3 family. http://togogenome.org/gene/31033:pigx ^@ http://purl.uniprot.org/uniprot/A0A3B5KB36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGX family.|||Endoplasmic reticulum membrane|||Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. http://togogenome.org/gene/31033:LOC101074178 ^@ http://purl.uniprot.org/uniprot/A0A3B5KJW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/31033:LOC101066969 ^@ http://purl.uniprot.org/uniprot/A0A674PKM4 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/31033:stx16 ^@ http://purl.uniprot.org/uniprot/A0A3B5K3L5 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/31033:ube2f ^@ http://purl.uniprot.org/uniprot/H2T1W2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/31033:LOC101070493 ^@ http://purl.uniprot.org/uniprot/H2UR24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial Rho GTPase family.|||Membrane|||Mitochondrial GTPase involved in mitochondrial trafficking.|||Mitochondrion outer membrane http://togogenome.org/gene/31033:mapk1 ^@ http://purl.uniprot.org/uniprot/A0A674PAT2 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/31033:ldlr ^@ http://purl.uniprot.org/uniprot/A0A7G7XWQ0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:cacnb1 ^@ http://purl.uniprot.org/uniprot/A0A674N726 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||Membrane|||sarcolemma http://togogenome.org/gene/31033:nkx2-1 ^@ http://purl.uniprot.org/uniprot/H2TZH3 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101067924 ^@ http://purl.uniprot.org/uniprot/H2UMV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane|||Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. http://togogenome.org/gene/31033:kit ^@ http://purl.uniprot.org/uniprot/A0A674MR93|||http://purl.uniprot.org/uniprot/Q8AXC6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Autophosphorylated on tyrosine residues. Phosphorylated tyrosine residues are important for interaction with specific binding partners (By similarity).|||Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane|||Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine kitlg/scf and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.|||Ubiquitinated. Rapidly ubiquitinated after autophosphorylation induced by kitlg/scf binding, leading to internalization and degradation. http://togogenome.org/gene/31033:chfr ^@ http://purl.uniprot.org/uniprot/H2U8D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CHFR family.|||PML body http://togogenome.org/gene/31033:suz12 ^@ http://purl.uniprot.org/uniprot/H2U1A3 ^@ Similarity ^@ Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family. http://togogenome.org/gene/31033:cavin2 ^@ http://purl.uniprot.org/uniprot/H2S518 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/31033:slc41a3 ^@ http://purl.uniprot.org/uniprot/S0BBS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/31033:arfgef1 ^@ http://purl.uniprot.org/uniprot/A0A674NYJ5 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||perinuclear region http://togogenome.org/gene/31033:LOC101067409 ^@ http://purl.uniprot.org/uniprot/H2RYS6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.|||Preautophagosomal structure membrane http://togogenome.org/gene/31033:cldn7b ^@ http://purl.uniprot.org/uniprot/Q6E5U0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:irak1bp1 ^@ http://purl.uniprot.org/uniprot/H2RSG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRAK1BP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:xkr4 ^@ http://purl.uniprot.org/uniprot/H2TIE7|||http://purl.uniprot.org/uniprot/Q5GH51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/31033:scamp3 ^@ http://purl.uniprot.org/uniprot/H2TY00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/31033:llph ^@ http://purl.uniprot.org/uniprot/H2UR87 ^@ Similarity ^@ Belongs to the learning-associated protein family. http://togogenome.org/gene/31033:LOC101078052 ^@ http://purl.uniprot.org/uniprot/A0A674NPC2 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101071119 ^@ http://purl.uniprot.org/uniprot/H2TB59 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/31033:stx4 ^@ http://purl.uniprot.org/uniprot/H2TV56 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/31033:LOC101079551 ^@ http://purl.uniprot.org/uniprot/H2T1D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:cdk8 ^@ http://purl.uniprot.org/uniprot/H2SAH6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:LOC101066095 ^@ http://purl.uniprot.org/uniprot/H2UC35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hedgehog family.|||Cell membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Multimer.|||The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.|||The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. http://togogenome.org/gene/31033:mgme1 ^@ http://purl.uniprot.org/uniprot/H2SV95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGME1 family.|||Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair.|||Mitochondrion http://togogenome.org/gene/31033:gucy1a2 ^@ http://purl.uniprot.org/uniprot/H2T147 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101068984 ^@ http://purl.uniprot.org/uniprot/A0A6I8PJ16 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:cldn30c ^@ http://purl.uniprot.org/uniprot/Q6E5R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/31033:vangl2 ^@ http://purl.uniprot.org/uniprot/H2TJ08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:arcn1 ^@ http://purl.uniprot.org/uniprot/H2TNI1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/31033:LOC101076406 ^@ http://purl.uniprot.org/uniprot/H2URS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/31033:LOC101070981 ^@ http://purl.uniprot.org/uniprot/H2SZ21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STOP family.|||cytoskeleton http://togogenome.org/gene/31033:stx7 ^@ http://purl.uniprot.org/uniprot/H2UBE9 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/31033:mmgt1 ^@ http://purl.uniprot.org/uniprot/H2SBN1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane magnesium transporter (TC 1.A.67) family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport. http://togogenome.org/gene/31033:penk ^@ http://purl.uniprot.org/uniprot/H2TMB9 ^@ Similarity ^@ Belongs to the opioid neuropeptide precursor family. http://togogenome.org/gene/31033:pde6g ^@ http://purl.uniprot.org/uniprot/A0A674PJW3 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/31033:LOC101062512 ^@ http://purl.uniprot.org/uniprot/H2T2A6 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/31033:LOC101075191 ^@ http://purl.uniprot.org/uniprot/H2THL4 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/31033:f8 ^@ http://purl.uniprot.org/uniprot/Q804W6 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/31033:ddx3x ^@ http://purl.uniprot.org/uniprot/A0A674MFT2|||http://purl.uniprot.org/uniprot/H2UFU0|||http://purl.uniprot.org/uniprot/H2UFU1 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/31033:sumo1 ^@ http://purl.uniprot.org/uniprot/A0A674MKB3|||http://purl.uniprot.org/uniprot/A0A674MY12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/31033:LOC101070521 ^@ http://purl.uniprot.org/uniprot/H2SWR8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/31033:miga2 ^@ http://purl.uniprot.org/uniprot/H2VCR9 ^@ Similarity ^@ Belongs to the mitoguardin family. http://togogenome.org/gene/31033:cd247 ^@ http://purl.uniprot.org/uniprot/A0A3B5KEI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD3Z/FCER1G family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101064624 ^@ http://purl.uniprot.org/uniprot/H2RYX7 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/31033:LOC101062827 ^@ http://purl.uniprot.org/uniprot/H2UII0 ^@ Similarity ^@ Belongs to the RimK family. http://togogenome.org/gene/31033:LOC101064658 ^@ http://purl.uniprot.org/uniprot/A0A3B5K887 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PUR DNA-binding protein family.|||Nucleus http://togogenome.org/gene/31033:lhx8 ^@ http://purl.uniprot.org/uniprot/H2V7E7 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101073101 ^@ http://purl.uniprot.org/uniprot/H2SXW2|||http://purl.uniprot.org/uniprot/H2SXW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/31033:LOC101072649 ^@ http://purl.uniprot.org/uniprot/H2UNV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Elbow/Noc family.|||Nucleus http://togogenome.org/gene/31033:ptn ^@ http://purl.uniprot.org/uniprot/H2UUT2 ^@ Similarity ^@ Belongs to the pleiotrophin family. http://togogenome.org/gene/31033:LOC101072849 ^@ http://purl.uniprot.org/uniprot/A0A674PFR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Nucleus http://togogenome.org/gene/31033:LOC101080112 ^@ http://purl.uniprot.org/uniprot/A0A3B5K117 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/31033:LOC101071776 ^@ http://purl.uniprot.org/uniprot/H2SW89 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/31033:zdhhc13 ^@ http://purl.uniprot.org/uniprot/H2UT65 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Cytoplasmic vesicle membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/31033:cldn27b ^@ http://purl.uniprot.org/uniprot/Q6E5Q5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:LOC101064958 ^@ http://purl.uniprot.org/uniprot/A0A3B5KQI3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/31033:six4 ^@ http://purl.uniprot.org/uniprot/H2TQP7 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101074651 ^@ http://purl.uniprot.org/uniprot/H2SK97 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/31033:mapk10 ^@ http://purl.uniprot.org/uniprot/A0A674MHI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/31033:mms22l ^@ http://purl.uniprot.org/uniprot/H2RK09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MMS22 family. MMS22L subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/31033:LOC101072853 ^@ http://purl.uniprot.org/uniprot/A0A674NAU6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:LOC101074421 ^@ http://purl.uniprot.org/uniprot/H2RPQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/31033:ednra ^@ http://purl.uniprot.org/uniprot/A3KE13 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/31033:LOC101075584 ^@ http://purl.uniprot.org/uniprot/H2UXG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:ube2s ^@ http://purl.uniprot.org/uniprot/H2S8M4 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/31033:gkap1 ^@ http://purl.uniprot.org/uniprot/H2TUF1 ^@ Similarity ^@ Belongs to the GKAP1 family. http://togogenome.org/gene/31033:lypla2 ^@ http://purl.uniprot.org/uniprot/A0A674NT07 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/31033:ormdl1 ^@ http://purl.uniprot.org/uniprot/A0A674PJL5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/31033:hao1 ^@ http://purl.uniprot.org/uniprot/H2TDV8 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/31033:LOC101065546 ^@ http://purl.uniprot.org/uniprot/H2U656 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/31033:LOC101063159 ^@ http://purl.uniprot.org/uniprot/H2TVL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. http://togogenome.org/gene/31033:LOC101073503 ^@ http://purl.uniprot.org/uniprot/A0A674PQI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||Secreted http://togogenome.org/gene/31033:evx1 ^@ http://purl.uniprot.org/uniprot/Q1KL23 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101066563 ^@ http://purl.uniprot.org/uniprot/A0A3B5KG61 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/31033:LOC101062046 ^@ http://purl.uniprot.org/uniprot/H2SPA9 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 zinc ion per subunit.|||Homotetramer.|||Involved in the regulation of homocysteine metabolism. http://togogenome.org/gene/31033:gje1 ^@ http://purl.uniprot.org/uniprot/A0A674MMZ8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101079447 ^@ http://purl.uniprot.org/uniprot/H2V3B5 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:ddx41 ^@ http://purl.uniprot.org/uniprot/A0A3B5K304 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX41 subfamily. http://togogenome.org/gene/31033:slc6a2 ^@ http://purl.uniprot.org/uniprot/H2TS08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/31033:coq7 ^@ http://purl.uniprot.org/uniprot/H2TZ78 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ7 family.|||Binds 2 iron ions per subunit.|||Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:dbnl ^@ http://purl.uniprot.org/uniprot/A0A674M8V7|||http://purl.uniprot.org/uniprot/A0A674P8N3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABP1 family.|||Early endosome|||Golgi apparatus membrane|||Perikaryon|||Postsynaptic density|||cell cortex|||clathrin-coated vesicle membrane|||dendrite|||lamellipodium|||neuron projection|||podosome|||ruffle http://togogenome.org/gene/31033:LOC101062972 ^@ http://purl.uniprot.org/uniprot/A0A674NFZ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||Vacuole membrane|||clathrin-coated vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/31033:LOC101072470 ^@ http://purl.uniprot.org/uniprot/H2SB25 ^@ Similarity ^@ Belongs to the pellino family. http://togogenome.org/gene/31033:malt1 ^@ http://purl.uniprot.org/uniprot/A0A674NVZ9|||http://purl.uniprot.org/uniprot/H2V1L9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101074060 ^@ http://purl.uniprot.org/uniprot/H2V488 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/31033:rrp7a ^@ http://purl.uniprot.org/uniprot/A0A3B5KCP9 ^@ Similarity ^@ Belongs to the RRP7 family. http://togogenome.org/gene/31033:LOC101071639 ^@ http://purl.uniprot.org/uniprot/H2U0I9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:slc2a4 ^@ http://purl.uniprot.org/uniprot/H2TZU8 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/31033:charon ^@ http://purl.uniprot.org/uniprot/Q76C28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/31033:mkrn1 ^@ http://purl.uniprot.org/uniprot/Q5NU14 ^@ Function|||Miscellaneous ^@ E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.|||Non-canonical splice acceptor and donor sites. http://togogenome.org/gene/31033:LOC101078030 ^@ http://purl.uniprot.org/uniprot/A0A674PPP5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Homodimer. Heterodimer with HTR1D.|||Membrane http://togogenome.org/gene/31033:ttc9 ^@ http://purl.uniprot.org/uniprot/A0A3B5KLR1 ^@ Similarity ^@ Belongs to the TTC9 family. http://togogenome.org/gene/31033:pax5 ^@ http://purl.uniprot.org/uniprot/Q3LFR5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:pigk ^@ http://purl.uniprot.org/uniprot/H2SUF3 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C13 family.|||Forms a complex with PIGT, PIGS, PIGU and GAA1. http://togogenome.org/gene/31033:nop56 ^@ http://purl.uniprot.org/uniprot/A0A674MP14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus http://togogenome.org/gene/31033:vps33b ^@ http://purl.uniprot.org/uniprot/H2UJI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/31033:capza2 ^@ http://purl.uniprot.org/uniprot/A0A674P3V0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/31033:rheb ^@ http://purl.uniprot.org/uniprot/A0A3B5KK68 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/31033:LOC101067011 ^@ http://purl.uniprot.org/uniprot/H2U445 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.|||Membrane http://togogenome.org/gene/31033:cenph ^@ http://purl.uniprot.org/uniprot/A0A3B5KA53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-H/MCM16 family.|||Nucleus|||kinetochore http://togogenome.org/gene/31033:drd5 ^@ http://purl.uniprot.org/uniprot/A0A3B5K8K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101066073 ^@ http://purl.uniprot.org/uniprot/H2RK12 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/31033:LOC101072768 ^@ http://purl.uniprot.org/uniprot/Q1KKY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:exoc3 ^@ http://purl.uniprot.org/uniprot/H2TC32 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/31033:cs ^@ http://purl.uniprot.org/uniprot/H2UPT3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the citrate synthase family.|||Homodimer.|||Mitochondrion matrix http://togogenome.org/gene/31033:plp2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KFT4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101077815 ^@ http://purl.uniprot.org/uniprot/A0A674PP22 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101068996 ^@ http://purl.uniprot.org/uniprot/H2UZL2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/31033:aldh1a2 ^@ http://purl.uniprot.org/uniprot/Q402D1 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/31033:LOC101065572 ^@ http://purl.uniprot.org/uniprot/H2URW4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC105417853 ^@ http://purl.uniprot.org/uniprot/H2TFB9 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/31033:eml4 ^@ http://purl.uniprot.org/uniprot/H2SVC1 ^@ Similarity ^@ Belongs to the WD repeat EMAP family. http://togogenome.org/gene/31033:ugt8 ^@ http://purl.uniprot.org/uniprot/A0A674MHY8 ^@ Similarity ^@ Belongs to the UDP-glycosyltransferase family. http://togogenome.org/gene/31033:LOC101079934 ^@ http://purl.uniprot.org/uniprot/A0A674NYW8 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/31033:cab39l ^@ http://purl.uniprot.org/uniprot/H2SHW6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/31033:LOC101065874 ^@ http://purl.uniprot.org/uniprot/H2UVB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/31033:LOC101062287 ^@ http://purl.uniprot.org/uniprot/A0A674MUI4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/31033:LOC101063536 ^@ http://purl.uniprot.org/uniprot/H2USK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/31033:LOC101075459 ^@ http://purl.uniprot.org/uniprot/H2TYI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/31033:ndufv2 ^@ http://purl.uniprot.org/uniprot/H2T793 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. http://togogenome.org/gene/31033:LOC101062553 ^@ http://purl.uniprot.org/uniprot/H2S916 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/31033:LOC105417634 ^@ http://purl.uniprot.org/uniprot/A0A3B5KGE6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/31033:LOC101079122 ^@ http://purl.uniprot.org/uniprot/A0A674PB23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/31033:pga ^@ http://purl.uniprot.org/uniprot/Q5TLU9 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/31033:ndufa5 ^@ http://purl.uniprot.org/uniprot/H2TMC3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:LOC115246437 ^@ http://purl.uniprot.org/uniprot/H2RQY7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 6c family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:LOC101075392 ^@ http://purl.uniprot.org/uniprot/A0A3B5K5Y2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:bckdk ^@ http://purl.uniprot.org/uniprot/H2U5Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/31033:LOC101068806 ^@ http://purl.uniprot.org/uniprot/H2SFM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:spc24 ^@ http://purl.uniprot.org/uniprot/A0A3B5JY83 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC24 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/31033:fam20c4 ^@ http://purl.uniprot.org/uniprot/H2S6R4 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/31033:nup88 ^@ http://purl.uniprot.org/uniprot/A0A3B5KMA8 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/31033:LOC101076371 ^@ http://purl.uniprot.org/uniprot/H2U3W2 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/31033:ndufa13 ^@ http://purl.uniprot.org/uniprot/A0A674MA45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I NDUFA13 subunit family.|||Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:cldn33c ^@ http://purl.uniprot.org/uniprot/Q6E5U5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:LOC101074872 ^@ http://purl.uniprot.org/uniprot/H2UCM8 ^@ Similarity ^@ Belongs to the GDNFR family. http://togogenome.org/gene/31033:LOC101072454 ^@ http://purl.uniprot.org/uniprot/A0A3B5K9J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/31033:stat3 ^@ http://purl.uniprot.org/uniprot/A0A3B5K909|||http://purl.uniprot.org/uniprot/A0A3B5KEM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:usp39 ^@ http://purl.uniprot.org/uniprot/H2TV64 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:tnmd ^@ http://purl.uniprot.org/uniprot/H2TTD1 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/31033:LOC101065989 ^@ http://purl.uniprot.org/uniprot/H2U038 ^@ Similarity ^@ Belongs to the CRK family. http://togogenome.org/gene/31033:cyp17a2 ^@ http://purl.uniprot.org/uniprot/A7U485 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/31033:foxf2 ^@ http://purl.uniprot.org/uniprot/H2T0M4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101071984 ^@ http://purl.uniprot.org/uniprot/A0A674NH48 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/31033:fmo ^@ http://purl.uniprot.org/uniprot/Q802T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:LOC101076622 ^@ http://purl.uniprot.org/uniprot/H2RUY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:gabpa ^@ http://purl.uniprot.org/uniprot/H2TQW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/31033:LOC101062630 ^@ http://purl.uniprot.org/uniprot/H2V4M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||cilium membrane http://togogenome.org/gene/31033:LOC101072159 ^@ http://purl.uniprot.org/uniprot/A0A3B5JY15 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).|||Membrane|||Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. http://togogenome.org/gene/31033:LOC101073009 ^@ http://purl.uniprot.org/uniprot/H2TQ88 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRB/QCR7 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:LOC101074699 ^@ http://purl.uniprot.org/uniprot/H2TVT1 ^@ Similarity ^@ Belongs to the epsin family. http://togogenome.org/gene/31033:rpn2 ^@ http://purl.uniprot.org/uniprot/A0A674PLT1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SWP1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/31033:atp5f1c ^@ http://purl.uniprot.org/uniprot/H2TPW6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/31033:LOC101075901 ^@ http://purl.uniprot.org/uniprot/H2V214 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/31033:prdm10 ^@ http://purl.uniprot.org/uniprot/H2TWQ1 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/31033:tph2 ^@ http://purl.uniprot.org/uniprot/Q6IWN1 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/31033:upp2 ^@ http://purl.uniprot.org/uniprot/H2SWA5 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. http://togogenome.org/gene/31033:LOC101064972 ^@ http://purl.uniprot.org/uniprot/Q8JG07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101076657 ^@ http://purl.uniprot.org/uniprot/H2SWH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/31033:LOC101070637 ^@ http://purl.uniprot.org/uniprot/A0A674MH25 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:LOC101076423 ^@ http://purl.uniprot.org/uniprot/A0A674NBB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nectin family.|||Membrane http://togogenome.org/gene/31033:rxra ^@ http://purl.uniprot.org/uniprot/A0A674PLN8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Homodimer. Heterodimer; with a rar molecule.|||Nucleus|||Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. http://togogenome.org/gene/31033:LOC105417509 ^@ http://purl.uniprot.org/uniprot/D4AHP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/31033:LOC101077396 ^@ http://purl.uniprot.org/uniprot/A0A674MDJ2 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/31033:sptssb ^@ http://purl.uniprot.org/uniprot/H2SPY6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:LOC101072362 ^@ http://purl.uniprot.org/uniprot/H2UM37 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/31033:LOC101061314 ^@ http://purl.uniprot.org/uniprot/A0A674NLC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:tmem57 ^@ http://purl.uniprot.org/uniprot/Q2TLY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the macoilin family.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/31033:emp2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KB43 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:LOC101064914 ^@ http://purl.uniprot.org/uniprot/Q7SZG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Nucleus http://togogenome.org/gene/31033:LOC101070944 ^@ http://purl.uniprot.org/uniprot/A0A674PD63 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/31033:LOC101079748 ^@ http://purl.uniprot.org/uniprot/H2TVY7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/31033:LOC101063692 ^@ http://purl.uniprot.org/uniprot/H2TP05 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/31033:sec22c ^@ http://purl.uniprot.org/uniprot/H2V792 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/31033:psmg1 ^@ http://purl.uniprot.org/uniprot/H2RYL9 ^@ Similarity ^@ Belongs to the PSMG1 family. http://togogenome.org/gene/31033:fgf8 ^@ http://purl.uniprot.org/uniprot/A0A674MAY7 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/31033:LOC101071662 ^@ http://purl.uniprot.org/uniprot/H2S672 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.|||Binds 2 magnesium ions per subunit.|||Nucleus http://togogenome.org/gene/31033:LOC101078069 ^@ http://purl.uniprot.org/uniprot/Q1KKU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101074721 ^@ http://purl.uniprot.org/uniprot/H2SMT1 ^@ Similarity ^@ Belongs to the opioid neuropeptide precursor family. http://togogenome.org/gene/31033:st6galnac5 ^@ http://purl.uniprot.org/uniprot/Q6ZXY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/31033:nppb ^@ http://purl.uniprot.org/uniprot/Q805D7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Has a cGMP-stimulating activity (By similarity).|||Secreted http://togogenome.org/gene/31033:LOC101073780 ^@ http://purl.uniprot.org/uniprot/H2TEP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. LISCH7 family.|||Membrane|||tight junction http://togogenome.org/gene/31033:c8a ^@ http://purl.uniprot.org/uniprot/A0A674N1F2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/31033:tbx1 ^@ http://purl.uniprot.org/uniprot/H2UFY5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/31033:LOC101076843 ^@ http://purl.uniprot.org/uniprot/Q800B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/31033:polr2c ^@ http://purl.uniprot.org/uniprot/H2SFB7 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/31033:adcy5 ^@ http://purl.uniprot.org/uniprot/A0A674N152 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/31033:myod ^@ http://purl.uniprot.org/uniprot/Q6Q2A8 ^@ Function|||Miscellaneous|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Expressed in fast and myotomal muscle. Very weak expression in brain, skin and gonads.|||May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.|||Most abundant isoform.|||Nucleus http://togogenome.org/gene/31033:hpse ^@ http://purl.uniprot.org/uniprot/H2VEW5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/31033:LOC101078025 ^@ http://purl.uniprot.org/uniprot/H2U1R6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:pnpo ^@ http://purl.uniprot.org/uniprot/H2U3U1 ^@ Function|||Similarity ^@ Belongs to the pyridoxamine 5'-phosphate oxidase family.|||Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). http://togogenome.org/gene/31033:LOC101078763 ^@ http://purl.uniprot.org/uniprot/H2T7K1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane http://togogenome.org/gene/31033:LOC101077035 ^@ http://purl.uniprot.org/uniprot/H2RS58 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:tti2 ^@ http://purl.uniprot.org/uniprot/A0A674MMZ5 ^@ Similarity ^@ Belongs to the TTI2 family. http://togogenome.org/gene/31033:LOC101076410 ^@ http://purl.uniprot.org/uniprot/H2SJJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||Cytoplasm|||Major role in the synthesis of nucleoside triphosphates other than ATP.|||Nucleus|||lamellipodium|||ruffle http://togogenome.org/gene/31033:plod2 ^@ http://purl.uniprot.org/uniprot/A5A6S3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/31033:uhrf1 ^@ http://purl.uniprot.org/uniprot/H2TMV9 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.|||Nucleus|||The YDG domain mediates the interaction with histone H3.|||The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3). http://togogenome.org/gene/31033:mapkap1 ^@ http://purl.uniprot.org/uniprot/H2RTX7 ^@ Similarity ^@ Belongs to the SIN1 family. http://togogenome.org/gene/31033:KEF89_p12 ^@ http://purl.uniprot.org/uniprot/Q8HCW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 2 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/31033:ptgir ^@ http://purl.uniprot.org/uniprot/H2TY14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:meaf6 ^@ http://purl.uniprot.org/uniprot/H2TLM1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EAF6 family.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.|||Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.|||kinetochore|||nucleolus http://togogenome.org/gene/31033:LOC101069563 ^@ http://purl.uniprot.org/uniprot/H2SG42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/31033:LOC101066156 ^@ http://purl.uniprot.org/uniprot/A0A3B5KIY9 ^@ Function|||Similarity ^@ Belongs to the KCMF1 family.|||Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination. http://togogenome.org/gene/31033:LOC101071071 ^@ http://purl.uniprot.org/uniprot/A0A674NRX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/31033:nbl1 ^@ http://purl.uniprot.org/uniprot/H2TK82 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/31033:dio1 ^@ http://purl.uniprot.org/uniprot/B1B569 ^@ Function|||Similarity ^@ Belongs to the iodothyronine deiodinase family.|||Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine). http://togogenome.org/gene/31033:sys1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K962 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYS1 family.|||Golgi apparatus membrane|||Interacts with ARFRP1.|||Involved in protein trafficking. May serve as a receptor for ARFRP1.|||Membrane http://togogenome.org/gene/31033:LOC101062073 ^@ http://purl.uniprot.org/uniprot/A0A3B5KPJ3 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/31033:pdcl ^@ http://purl.uniprot.org/uniprot/A0A3B5KIS2 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/31033:znf706 ^@ http://purl.uniprot.org/uniprot/H2TZU1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/31033:snx30 ^@ http://purl.uniprot.org/uniprot/H2SUU2 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/31033:LOC101071288 ^@ http://purl.uniprot.org/uniprot/A0A3B5K7Q8 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/31033:LOC105418153 ^@ http://purl.uniprot.org/uniprot/H2THS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:rspo2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KC46 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/31033:tp53rk ^@ http://purl.uniprot.org/uniprot/A0A674NJ29 ^@ Similarity ^@ Belongs to the protein kinase superfamily. BUD32 family. http://togogenome.org/gene/31033:cwc25 ^@ http://purl.uniprot.org/uniprot/H2SF70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CWC25 family.|||Nucleus http://togogenome.org/gene/31033:pmvk ^@ http://purl.uniprot.org/uniprot/H2RJ43 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/31033:LOC101073714 ^@ http://purl.uniprot.org/uniprot/A0A674N1U4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101063308 ^@ http://purl.uniprot.org/uniprot/H2UZD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:LOC101079641 ^@ http://purl.uniprot.org/uniprot/Q1KKX1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:chrm2 ^@ http://purl.uniprot.org/uniprot/Q66LI8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. http://togogenome.org/gene/31033:spc25 ^@ http://purl.uniprot.org/uniprot/A0A3B5K4M6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC25 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/31033:LOC101079925 ^@ http://purl.uniprot.org/uniprot/A0A674NWU1 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I family. http://togogenome.org/gene/31033:htt ^@ http://purl.uniprot.org/uniprot/A0A674MJN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the huntingtin family.|||Cytoplasm|||May play a role in microtubule-mediated transport or vesicle function.|||Nucleus http://togogenome.org/gene/31033:vdac1 ^@ http://purl.uniprot.org/uniprot/A0A674PD97 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/31033:srm ^@ http://purl.uniprot.org/uniprot/A0A3B5K8F4 ^@ Similarity ^@ Belongs to the spermidine/spermine synthase family. http://togogenome.org/gene/31033:dennd6a ^@ http://purl.uniprot.org/uniprot/A0A3B5JZ83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND6 family.|||Recycling endosome http://togogenome.org/gene/31033:txnl4a ^@ http://purl.uniprot.org/uniprot/H2UEM8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/31033:LOC101078976 ^@ http://purl.uniprot.org/uniprot/A0A674NWR6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101069844 ^@ http://purl.uniprot.org/uniprot/H2TCH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.|||Membrane http://togogenome.org/gene/31033:LOC101079822 ^@ http://purl.uniprot.org/uniprot/Q1KKZ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101066411 ^@ http://purl.uniprot.org/uniprot/A0A674MCF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/31033:LOC101063578 ^@ http://purl.uniprot.org/uniprot/H2T4S6 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/31033:fbxo9 ^@ http://purl.uniprot.org/uniprot/H2UN75 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9).|||Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and acts as a regulator of mTOR signaling. http://togogenome.org/gene/31033:LOC101062691 ^@ http://purl.uniprot.org/uniprot/H2SSP1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/31033:nim1k ^@ http://purl.uniprot.org/uniprot/H2UNU5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:LOC101078778 ^@ http://purl.uniprot.org/uniprot/A0A3B5KA08 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:polr3d ^@ http://purl.uniprot.org/uniprot/H2S7H0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:sptlc3 ^@ http://purl.uniprot.org/uniprot/A0A674MX77 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/31033:agrp2 ^@ http://purl.uniprot.org/uniprot/A0ZSG7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/31033:opa3 ^@ http://purl.uniprot.org/uniprot/H2UP11 ^@ Function|||Similarity ^@ Belongs to the OPA3 family.|||May play some role in mitochondrial processes. http://togogenome.org/gene/31033:LOC101079972 ^@ http://purl.uniprot.org/uniprot/H2SUU6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:tubgcp4 ^@ http://purl.uniprot.org/uniprot/H2UBS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/31033:stc2 ^@ http://purl.uniprot.org/uniprot/Q5IRA9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked.|||Its primary function is the prevention of hypercalcemia. Upon release into the circulation, it lowers calcium transport by the gills, thereby reducing its rate of influx from the environment into the extracellular compartment. STC also stimulates phosphate reabsorption by renal proximal tubules. The consequence of this action is increased levels of plasma phosphate, which combines with excess calcium and promotes its disposal into bone and scales. http://togogenome.org/gene/31033:shroom2 ^@ http://purl.uniprot.org/uniprot/H2U2W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shroom family.|||cytoskeleton http://togogenome.org/gene/31033:LOC101076671 ^@ http://purl.uniprot.org/uniprot/H2UIJ1 ^@ Similarity ^@ Belongs to the SKI family. http://togogenome.org/gene/31033:dhrs3 ^@ http://purl.uniprot.org/uniprot/H2SUW1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/31033:LOC101067966 ^@ http://purl.uniprot.org/uniprot/A0A674PEX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/31033:LOC101067373 ^@ http://purl.uniprot.org/uniprot/A0A3B5K4W3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/31033:uckl1 ^@ http://purl.uniprot.org/uniprot/H2SBQ6 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/31033:rhcg2 ^@ http://purl.uniprot.org/uniprot/Q7T3R4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Apicolateral cell membrane|||Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.|||Homotrimer.|||Specifically expressed in the gill by pavement cells (at protein level). http://togogenome.org/gene/31033:atg5 ^@ http://purl.uniprot.org/uniprot/H2RL06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG5 family.|||Conjugated with ATG12.|||Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.|||May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.|||Preautophagosomal structure membrane http://togogenome.org/gene/31033:fen1 ^@ http://purl.uniprot.org/uniprot/H2U529 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Mitochondrion|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.|||nucleolus|||nucleoplasm http://togogenome.org/gene/31033:ndufb2 ^@ http://purl.uniprot.org/uniprot/H2USX8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:LOC101068997 ^@ http://purl.uniprot.org/uniprot/H2SUA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.|||Lateral cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synaptic cell membrane|||axon|||dendrite|||sarcolemma|||synaptosome http://togogenome.org/gene/31033:prpf18 ^@ http://purl.uniprot.org/uniprot/H2TUW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP18 family.|||Nucleus speckle http://togogenome.org/gene/31033:polr2l ^@ http://purl.uniprot.org/uniprot/H2V520 ^@ Similarity ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family. http://togogenome.org/gene/31033:LOC101076045 ^@ http://purl.uniprot.org/uniprot/A0A674PPN3 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/31033:slc9a5 ^@ http://purl.uniprot.org/uniprot/A0A674NBX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Membrane|||Recycling endosome membrane http://togogenome.org/gene/31033:tbc1d23 ^@ http://purl.uniprot.org/uniprot/H2TVU1 ^@ Subcellular Location Annotation ^@ trans-Golgi network http://togogenome.org/gene/31033:LOC101065051 ^@ http://purl.uniprot.org/uniprot/H2SBK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/31033:rbm17 ^@ http://purl.uniprot.org/uniprot/A0A3B5KPA8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the spliceosome.|||Nucleus|||Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. http://togogenome.org/gene/31033:atpsckmt ^@ http://purl.uniprot.org/uniprot/H2SWH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANT/ATPSC lysine N-methyltransferase family.|||Mitochondrion membrane http://togogenome.org/gene/31033:LOC101063399 ^@ http://purl.uniprot.org/uniprot/A0A674PQS7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/31033:mtnr1a ^@ http://purl.uniprot.org/uniprot/A0A674PRZ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity.|||Membrane http://togogenome.org/gene/31033:slc1a7 ^@ http://purl.uniprot.org/uniprot/A0A674N9F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/31033:LOC101066348 ^@ http://purl.uniprot.org/uniprot/H2T805 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/31033:tmem18 ^@ http://purl.uniprot.org/uniprot/A0A674P6C3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM18 family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/31033:bmp7 ^@ http://purl.uniprot.org/uniprot/A0A674MBF0 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/31033:dipk2a ^@ http://purl.uniprot.org/uniprot/A0A3B5KQ20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/31033:ctnnbl1 ^@ http://purl.uniprot.org/uniprot/A0A674NZC3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101076453 ^@ http://purl.uniprot.org/uniprot/H2SGY8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:dusp10 ^@ http://purl.uniprot.org/uniprot/A0A3B5KKU8 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/31033:pox1 ^@ http://purl.uniprot.org/uniprot/Q8AWX6 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101076648 ^@ http://purl.uniprot.org/uniprot/A0A3B5KIF4 ^@ Function|||Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. http://togogenome.org/gene/31033:kpnb1 ^@ http://purl.uniprot.org/uniprot/H2RMC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the importin beta family. Importin beta-1 subfamily.|||Cytoplasm http://togogenome.org/gene/31033:ergic1 ^@ http://purl.uniprot.org/uniprot/H2SXN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/31033:LOC101076381 ^@ http://purl.uniprot.org/uniprot/H2TSK5 ^@ Similarity|||Subunit ^@ Belongs to the GILT family.|||Dimer; disulfide-linked. http://togogenome.org/gene/31033:LOC101076676 ^@ http://purl.uniprot.org/uniprot/H2UHT6 ^@ Similarity ^@ Belongs to the peptidase M17 family. http://togogenome.org/gene/31033:kctd10 ^@ http://purl.uniprot.org/uniprot/A0A3B5KIC2 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/31033:LOC101075259 ^@ http://purl.uniprot.org/uniprot/H2VCR3 ^@ Similarity ^@ Belongs to the SERBP1-HABP4 family. http://togogenome.org/gene/31033:evc2 ^@ http://purl.uniprot.org/uniprot/Q670Z5 ^@ Subcellular Location Annotation ^@ Membrane|||cilium basal body|||cilium membrane http://togogenome.org/gene/31033:taf5 ^@ http://purl.uniprot.org/uniprot/A0A674NZA1 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/31033:LOC101063077 ^@ http://purl.uniprot.org/uniprot/H2UUH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/31033:rrn3 ^@ http://purl.uniprot.org/uniprot/A0A674NPN3 ^@ Similarity ^@ Belongs to the RRN3 family. http://togogenome.org/gene/31033:rbm8a ^@ http://purl.uniprot.org/uniprot/H2U993 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBM8A family.|||Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.|||Cytoplasm|||Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.|||Nucleus|||Nucleus speckle http://togogenome.org/gene/31033:LOC101069736 ^@ http://purl.uniprot.org/uniprot/H2SV55 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/31033:klhl21 ^@ http://purl.uniprot.org/uniprot/H2TCP1 ^@ Subcellular Location Annotation ^@ spindle http://togogenome.org/gene/31033:LOC101080058 ^@ http://purl.uniprot.org/uniprot/H2UST2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 5A family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:LOC101078514 ^@ http://purl.uniprot.org/uniprot/H2V4E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSG1 family.|||Membrane http://togogenome.org/gene/31033:eogt ^@ http://purl.uniprot.org/uniprot/Q5NDK8 ^@ Similarity ^@ Belongs to the glycosyltransferase 61 family. http://togogenome.org/gene/31033:LOC101072674 ^@ http://purl.uniprot.org/uniprot/H2V3T6 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/31033:tsn ^@ http://purl.uniprot.org/uniprot/H2UDE5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the translin family.|||DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.|||Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.|||Nucleus|||Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring. http://togogenome.org/gene/31033:gnb2 ^@ http://purl.uniprot.org/uniprot/A0A674NSM9 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/31033:LOC101064504 ^@ http://purl.uniprot.org/uniprot/A0A3B5KDX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Membrane http://togogenome.org/gene/31033:LOC101077101 ^@ http://purl.uniprot.org/uniprot/H2UFN1 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/31033:mrps30 ^@ http://purl.uniprot.org/uniprot/A0A3B5K3G9 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/31033:LOC101073431 ^@ http://purl.uniprot.org/uniprot/Q2PR39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101063371 ^@ http://purl.uniprot.org/uniprot/H2UMP9 ^@ Similarity ^@ Belongs to the ependymin family. http://togogenome.org/gene/31033:mapre2 ^@ http://purl.uniprot.org/uniprot/A0A674NAN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/31033:nme3 ^@ http://purl.uniprot.org/uniprot/H2SQ33 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||Cytoplasm|||Major role in the synthesis of nucleoside triphosphates other than ATP.|||Nucleus|||lamellipodium|||ruffle http://togogenome.org/gene/31033:hoxc12 ^@ http://purl.uniprot.org/uniprot/Q1KKV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:crybb1 ^@ http://purl.uniprot.org/uniprot/H2VEL6 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/31033:LOC101069147 ^@ http://purl.uniprot.org/uniprot/A0A674ND84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3A3 family.|||Nucleus http://togogenome.org/gene/31033:LOC101066841 ^@ http://purl.uniprot.org/uniprot/H2TGP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/31033:syndig1 ^@ http://purl.uniprot.org/uniprot/H2S8X3 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/31033:dhrs11 ^@ http://purl.uniprot.org/uniprot/H2SRY7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/31033:htr5a ^@ http://purl.uniprot.org/uniprot/H2V9C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:sec23a ^@ http://purl.uniprot.org/uniprot/H2SRP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/31033:LOC101079133 ^@ http://purl.uniprot.org/uniprot/A0A3B5JUW0 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/31033:LOC101065476 ^@ http://purl.uniprot.org/uniprot/A0A3B5KKU3 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/31033:mcm7 ^@ http://purl.uniprot.org/uniprot/H2UJM4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/31033:LOC101067509 ^@ http://purl.uniprot.org/uniprot/A0A674PNV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101074951 ^@ http://purl.uniprot.org/uniprot/Q801F2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:rab3gap1 ^@ http://purl.uniprot.org/uniprot/H2SMU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab3-GAP catalytic subunit family.|||Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/31033:f10 ^@ http://purl.uniprot.org/uniprot/Q804W9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular space http://togogenome.org/gene/31033:IL-12%20p40 ^@ http://purl.uniprot.org/uniprot/Q7SX69 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-12B family.|||Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.|||Secreted http://togogenome.org/gene/31033:tmem177 ^@ http://purl.uniprot.org/uniprot/A0A3B5JUS8 ^@ Function|||Similarity ^@ Belongs to the TMEM177 family.|||Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein. http://togogenome.org/gene/31033:LOC101078604 ^@ http://purl.uniprot.org/uniprot/H2UJB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Membrane http://togogenome.org/gene/31033:runx1 ^@ http://purl.uniprot.org/uniprot/A0A9N7|||http://purl.uniprot.org/uniprot/Q642Y3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:rab9b ^@ http://purl.uniprot.org/uniprot/H2TED5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||phagosome membrane http://togogenome.org/gene/31033:sf3a1 ^@ http://purl.uniprot.org/uniprot/H2SR29 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101068683 ^@ http://purl.uniprot.org/uniprot/H2UKE8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.|||Belongs to the carbohydrate kinase PfkB family.|||Binds 3 Mg(2+) ions per subunit.|||Monomer.|||Nucleus http://togogenome.org/gene/31033:phkg2 ^@ http://purl.uniprot.org/uniprot/H2UTA4 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily.|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/31033:psenen ^@ http://purl.uniprot.org/uniprot/A0A3B5KN82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PEN-2 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/31033:slc49a4 ^@ http://purl.uniprot.org/uniprot/H2UGN7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101078698 ^@ http://purl.uniprot.org/uniprot/Q2PR32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101075838 ^@ http://purl.uniprot.org/uniprot/A0A3B5JWV5 ^@ Similarity ^@ Belongs to the TBP family. http://togogenome.org/gene/31033:LOC777976 ^@ http://purl.uniprot.org/uniprot/Q2NNA7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the noggin family.|||Homodimer.|||Secreted http://togogenome.org/gene/31033:LOC101071000 ^@ http://purl.uniprot.org/uniprot/H2T7A2 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. http://togogenome.org/gene/31033:LOC101076009 ^@ http://purl.uniprot.org/uniprot/A0A674MA50 ^@ Similarity ^@ Belongs to the DNAJC25 family. http://togogenome.org/gene/31033:LOC101076688 ^@ http://purl.uniprot.org/uniprot/H2T0Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/31033:LOC101073835 ^@ http://purl.uniprot.org/uniprot/A0A674P3N0 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/31033:dstn ^@ http://purl.uniprot.org/uniprot/A0A3B5KBU5 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/31033:LOC101075603 ^@ http://purl.uniprot.org/uniprot/A0A674NVI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transglutaminase-like superfamily. PNGase family.|||Cytoplasm|||Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. http://togogenome.org/gene/31033:supt6h ^@ http://purl.uniprot.org/uniprot/A0A3B5KBU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT6 family.|||Nucleus|||Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). http://togogenome.org/gene/31033:LOC101069232 ^@ http://purl.uniprot.org/uniprot/Q90WS1 ^@ Function|||Similarity ^@ Belongs to the type IB topoisomerase family.|||Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/31033:LOC101074049 ^@ http://purl.uniprot.org/uniprot/A0A3B5K0C2|||http://purl.uniprot.org/uniprot/H2RSW0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:smim7 ^@ http://purl.uniprot.org/uniprot/A0A3B5JY56 ^@ Similarity ^@ Belongs to the SMIM7 family. http://togogenome.org/gene/31033:chmp2b ^@ http://purl.uniprot.org/uniprot/H2SAE2 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/31033:sncg ^@ http://purl.uniprot.org/uniprot/Q3LU28 ^@ Similarity|||Subunit ^@ Belongs to the synuclein family.|||May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation. http://togogenome.org/gene/31033:fam98b ^@ http://purl.uniprot.org/uniprot/H2UE24 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/31033:trarg1 ^@ http://purl.uniprot.org/uniprot/A0A674PPP2 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/31033:LOC101061436 ^@ http://purl.uniprot.org/uniprot/H2SEU8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/31033:LOC101073896 ^@ http://purl.uniprot.org/uniprot/H2SEE0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/31033:nfya ^@ http://purl.uniprot.org/uniprot/H2SA39 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NFYA/HAP2 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.|||Heterotrimer.|||Nucleus http://togogenome.org/gene/31033:LOC101073734 ^@ http://purl.uniprot.org/uniprot/H2TAG5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. http://togogenome.org/gene/31033:agrp1 ^@ http://purl.uniprot.org/uniprot/A0ZSG6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/31033:lrrc42 ^@ http://purl.uniprot.org/uniprot/A0A3B5KLZ3 ^@ Similarity ^@ Belongs to the LRRC42 family. http://togogenome.org/gene/31033:foxp2 ^@ http://purl.uniprot.org/uniprot/V6F872 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:htr1a-b ^@ http://purl.uniprot.org/uniprot/O42384 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity and behavior (By similarity). http://togogenome.org/gene/31033:zranb1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KCA5 ^@ Similarity ^@ Belongs to the peptidase C64 family. http://togogenome.org/gene/31033:ccr10 ^@ http://purl.uniprot.org/uniprot/D6RRB8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:mgmt ^@ http://purl.uniprot.org/uniprot/A0A674PQ38 ^@ Similarity ^@ Belongs to the MGMT family. http://togogenome.org/gene/31033:LOC101075290 ^@ http://purl.uniprot.org/uniprot/H2T8S5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic10 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:rho ^@ http://purl.uniprot.org/uniprot/Q9IAH7 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Contains one covalently linked retinal chromophore.|||Membrane|||photoreceptor outer segment http://togogenome.org/gene/31033:LOC101064648 ^@ http://purl.uniprot.org/uniprot/H2UVH7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/31033:LOC101079870 ^@ http://purl.uniprot.org/uniprot/H2RN11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/31033:timm8a ^@ http://purl.uniprot.org/uniprot/Q90YI5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer; composed of 3 copies of TIMM8A and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22 (By similarity).|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of some proteins while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins (By similarity).|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM8A from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity). http://togogenome.org/gene/31033:scube3 ^@ http://purl.uniprot.org/uniprot/A0A674NE56|||http://purl.uniprot.org/uniprot/H2TMZ1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/31033:unc119b ^@ http://purl.uniprot.org/uniprot/H2UWX9 ^@ Similarity ^@ Belongs to the PDE6D/unc-119 family. http://togogenome.org/gene/31033:otud7b ^@ http://purl.uniprot.org/uniprot/H2U9M5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/31033:LOC101079930 ^@ http://purl.uniprot.org/uniprot/A0A674PME4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/31033:mrpl49 ^@ http://purl.uniprot.org/uniprot/H2RY40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL49 family.|||Mitochondrion http://togogenome.org/gene/31033:LOC101077900 ^@ http://purl.uniprot.org/uniprot/H2RR19 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Early endosome|||Endosome|||Involved in trafficking and recycling of synaptic vesicles.|||Late endosome|||Membrane|||Recycling endosome|||autophagosome|||synaptic vesicle|||trans-Golgi network http://togogenome.org/gene/31033:LOC101078094 ^@ http://purl.uniprot.org/uniprot/Q9W6R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||clathrin-coated pit http://togogenome.org/gene/31033:senp8 ^@ http://purl.uniprot.org/uniprot/H2UYZ1 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/31033:dot1l ^@ http://purl.uniprot.org/uniprot/H2V929 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.|||Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.|||In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.|||Nucleus http://togogenome.org/gene/31033:LOC101071051 ^@ http://purl.uniprot.org/uniprot/H2V532 ^@ Similarity ^@ Belongs to the nucleobindin family. http://togogenome.org/gene/31033:cxcr4 ^@ http://purl.uniprot.org/uniprot/H2TD98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/31033:LOC101066780 ^@ http://purl.uniprot.org/uniprot/A0A674MTR9 ^@ Similarity ^@ Belongs to the proteasome subunit S9 family. http://togogenome.org/gene/31033:xkr9 ^@ http://purl.uniprot.org/uniprot/Q5GH45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/31033:spsb3 ^@ http://purl.uniprot.org/uniprot/H2SIH5 ^@ Function|||Similarity ^@ Belongs to the SPSB family.|||May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/31033:galr1 ^@ http://purl.uniprot.org/uniprot/H2V675 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/31033:got2 ^@ http://purl.uniprot.org/uniprot/H2VAC0 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/31033:atg4d ^@ http://purl.uniprot.org/uniprot/H2RSB2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/31033:LOC101074126 ^@ http://purl.uniprot.org/uniprot/H2UB72 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular space http://togogenome.org/gene/31033:krtcap3 ^@ http://purl.uniprot.org/uniprot/H2SGK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM54 family.|||Membrane http://togogenome.org/gene/31033:LOC101077703 ^@ http://purl.uniprot.org/uniprot/A0A674N037 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Secreted http://togogenome.org/gene/31033:LOC101069671 ^@ http://purl.uniprot.org/uniprot/H2UX64 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/31033:LOC101063710 ^@ http://purl.uniprot.org/uniprot/A0A3B5K781 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/31033:mrps33 ^@ http://purl.uniprot.org/uniprot/A0A674PK58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS33 family.|||Mitochondrion http://togogenome.org/gene/31033:copa ^@ http://purl.uniprot.org/uniprot/H2TLX7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. http://togogenome.org/gene/31033:LOC101073060 ^@ http://purl.uniprot.org/uniprot/A0A3B5K9S6 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||RNA-binding protein that regulates alternative splicing events. http://togogenome.org/gene/31033:yju2 ^@ http://purl.uniprot.org/uniprot/A0A3B5K8W2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CWC16 family. YJU2 subfamily.|||Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.|||Nucleus|||Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex. http://togogenome.org/gene/31033:LOC101063632 ^@ http://purl.uniprot.org/uniprot/H2TED2 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/31033:fam219b ^@ http://purl.uniprot.org/uniprot/A0A3B5KKD2 ^@ Similarity ^@ Belongs to the FAM219 family. http://togogenome.org/gene/31033:actb ^@ http://purl.uniprot.org/uniprot/P68142 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.|||Belongs to the actin family.|||In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.|||Methylation at His-73 by SETD3. Methylation stabilizes actin filaments.|||N-terminal cleavage of acetylated methionine of immature cytoplasmic actin by ACTMAP.|||Nucleus|||Oxidation of Met-44 and Met-47 by MICALs (mical1, mical2 or mical3) to form methionine sulfoxide promotes actin filament depolymerization. Mical1 and mical2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by msrb1 and msrb2, which promote actin repolymerization.|||Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix (By similarity). Each actin can bind to 4 others (By similarity).|||There are three different beta-cytoplasmic actins in Fugu rubripes.|||Widely distributed. Not expressed in skeletal muscle.|||cytoskeleton http://togogenome.org/gene/31033:iars ^@ http://purl.uniprot.org/uniprot/H2SY46 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/31033:sult4a1 ^@ http://purl.uniprot.org/uniprot/H2THF9 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/31033:LOC101077147 ^@ http://purl.uniprot.org/uniprot/H2S6B3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/31033:aar2 ^@ http://purl.uniprot.org/uniprot/H2S162 ^@ Function|||Similarity ^@ Belongs to the AAR2 family.|||Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. http://togogenome.org/gene/31033:pacsin1 ^@ http://purl.uniprot.org/uniprot/H2TTB2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Cell projection|||Cytoplasm|||Membrane http://togogenome.org/gene/31033:LOC101072140 ^@ http://purl.uniprot.org/uniprot/A0A674PH95 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:LOC101070710 ^@ http://purl.uniprot.org/uniprot/H2RLZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Membrane http://togogenome.org/gene/31033:LOC101076201 ^@ http://purl.uniprot.org/uniprot/H2SQW9 ^@ Similarity ^@ Belongs to the RRM IMP/VICKZ family. http://togogenome.org/gene/31033:LOC101078278 ^@ http://purl.uniprot.org/uniprot/H2TEB6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101063229 ^@ http://purl.uniprot.org/uniprot/H2V2C8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/31033:vax2 ^@ http://purl.uniprot.org/uniprot/H2VAK3 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC497187 ^@ http://purl.uniprot.org/uniprot/H2U1E3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/31033:coq4 ^@ http://purl.uniprot.org/uniprot/A0A674MYP2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ4 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:lrp12 ^@ http://purl.uniprot.org/uniprot/A0A674MKQ5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:cldn34 ^@ http://purl.uniprot.org/uniprot/Q6E5P4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/31033:pigp ^@ http://purl.uniprot.org/uniprot/H2U9N8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGP family.|||Membrane|||Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. http://togogenome.org/gene/31033:met ^@ http://purl.uniprot.org/uniprot/Q9YGM7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:LOC101062950 ^@ http://purl.uniprot.org/uniprot/H2SM74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/31033:LOC101076691 ^@ http://purl.uniprot.org/uniprot/A0A3B5K6B9 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/31033:LOC101068316 ^@ http://purl.uniprot.org/uniprot/A0A674MLM6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:uck1 ^@ http://purl.uniprot.org/uniprot/H2VCE9 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/31033:ccdc167 ^@ http://purl.uniprot.org/uniprot/A0A3B5KIM7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:yars2 ^@ http://purl.uniprot.org/uniprot/H2UYT1 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/31033:LOC101068713 ^@ http://purl.uniprot.org/uniprot/H2SQY3 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/31033:LOC101077564 ^@ http://purl.uniprot.org/uniprot/H2V6H4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.|||Binds 1 FAD per subunit.|||May have a photoreceptor function. http://togogenome.org/gene/31033:LOC101064338 ^@ http://purl.uniprot.org/uniprot/A0A3B5KV91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the P33MONOX family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101072554 ^@ http://purl.uniprot.org/uniprot/A0A674NGT3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:trappc6b ^@ http://purl.uniprot.org/uniprot/H2SS24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/31033:LOC105417715 ^@ http://purl.uniprot.org/uniprot/H2RUY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:gpr135 ^@ http://purl.uniprot.org/uniprot/Q7T2L0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:tbccd1 ^@ http://purl.uniprot.org/uniprot/H2UQB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCC family.|||centrosome|||spindle pole http://togogenome.org/gene/31033:ppm1k ^@ http://purl.uniprot.org/uniprot/H2U271 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/31033:fgc6ast2 ^@ http://purl.uniprot.org/uniprot/Q14TH2 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:fyn ^@ http://purl.uniprot.org/uniprot/A0A6D2X158 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/31033:LOC100049643 ^@ http://purl.uniprot.org/uniprot/A1KZS9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Endosome|||Heterooligomeric complex.|||Membrane http://togogenome.org/gene/31033:LOC101075383 ^@ http://purl.uniprot.org/uniprot/H2SW62 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/31033:LOC101068056 ^@ http://purl.uniprot.org/uniprot/Q2PR37 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:npffr-2 ^@ http://purl.uniprot.org/uniprot/Q05KN2 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/31033:lzic ^@ http://purl.uniprot.org/uniprot/H2TSE0 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/31033:chac1 ^@ http://purl.uniprot.org/uniprot/A0A674PRH6 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/31033:LOC101069314 ^@ http://purl.uniprot.org/uniprot/H2V058 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:mrpl12 ^@ http://purl.uniprot.org/uniprot/A0A3B5KH94 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL12 family. http://togogenome.org/gene/31033:ublcp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KL27 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101071438 ^@ http://purl.uniprot.org/uniprot/A0A674PK66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/31033:ivd ^@ http://purl.uniprot.org/uniprot/H2U8G6 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/31033:LOC101066115 ^@ http://purl.uniprot.org/uniprot/H2U5M2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101075148 ^@ http://purl.uniprot.org/uniprot/A0A674NZG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/31033:lpl ^@ http://purl.uniprot.org/uniprot/L8B319 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Cell membrane|||Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.|||Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.|||extracellular matrix http://togogenome.org/gene/31033:LOC101079162 ^@ http://purl.uniprot.org/uniprot/A0A3B5K970 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/31033:coq3 ^@ http://purl.uniprot.org/uniprot/H2RKA9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Mitochondrion inner membrane|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. http://togogenome.org/gene/31033:LOC101072777 ^@ http://purl.uniprot.org/uniprot/A0A3B5K0S9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/31033:c20h19orf25 ^@ http://purl.uniprot.org/uniprot/A0A3B5K8X1 ^@ Similarity ^@ Belongs to the UPF0449 family. http://togogenome.org/gene/31033:timp3 ^@ http://purl.uniprot.org/uniprot/Q4JF88 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/31033:gprc6a ^@ http://purl.uniprot.org/uniprot/H2SYE2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC100653418 ^@ http://purl.uniprot.org/uniprot/E9LYZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/31033:tube1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KC14 ^@ Similarity ^@ Belongs to the tubulin family. http://togogenome.org/gene/31033:fam207a ^@ http://purl.uniprot.org/uniprot/A0A3B5KPM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLX9 family.|||nucleolus http://togogenome.org/gene/31033:manf ^@ http://purl.uniprot.org/uniprot/A0A674ND02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARMET family.|||Secreted http://togogenome.org/gene/31033:LOC101063973 ^@ http://purl.uniprot.org/uniprot/A0A3B5K9X0 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/31033:LOC101071997 ^@ http://purl.uniprot.org/uniprot/H2TFT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/31033:LOC101065168 ^@ http://purl.uniprot.org/uniprot/A0A674NTS2 ^@ Similarity ^@ Belongs to the UPF0415 family. http://togogenome.org/gene/31033:pus10 ^@ http://purl.uniprot.org/uniprot/H2S1W0 ^@ Similarity ^@ Belongs to the pseudouridine synthase Pus10 family. http://togogenome.org/gene/31033:LOC101068749 ^@ http://purl.uniprot.org/uniprot/A0A3B5K164 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:capn9 ^@ http://purl.uniprot.org/uniprot/H2S155 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/31033:LOC101064440 ^@ http://purl.uniprot.org/uniprot/H2RJV7 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/31033:LOC101061184 ^@ http://purl.uniprot.org/uniprot/H2TCX2 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101064641 ^@ http://purl.uniprot.org/uniprot/A0A674NWA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel HCN family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:exosc2 ^@ http://purl.uniprot.org/uniprot/A0A674PLK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP4 family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101064999 ^@ http://purl.uniprot.org/uniprot/H2S8L2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/31033:fis1 ^@ http://purl.uniprot.org/uniprot/A0A674NJ41 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIS1 family.|||Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.|||Membrane|||Mitochondrion outer membrane|||The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission. http://togogenome.org/gene/31033:LOC101062487 ^@ http://purl.uniprot.org/uniprot/A0A674MPG6 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:sema3g ^@ http://purl.uniprot.org/uniprot/A0A674MDN0 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101067138 ^@ http://purl.uniprot.org/uniprot/H2SVV3 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101074969 ^@ http://purl.uniprot.org/uniprot/A0A674PN33 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC446041 ^@ http://purl.uniprot.org/uniprot/Q6SYV3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Secreted http://togogenome.org/gene/31033:ndufa12 ^@ http://purl.uniprot.org/uniprot/A0A3B5KAS8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA12 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:irak4 ^@ http://purl.uniprot.org/uniprot/A0A3B5K2L4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.|||Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.|||Cytoplasm|||Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. http://togogenome.org/gene/31033:LOC101079677 ^@ http://purl.uniprot.org/uniprot/H2TWA3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/31033:lef1 ^@ http://purl.uniprot.org/uniprot/H2TAM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/31033:LOC101065354 ^@ http://purl.uniprot.org/uniprot/Q7SZG2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/31033:rapsn ^@ http://purl.uniprot.org/uniprot/H2UQA8 ^@ Similarity ^@ Belongs to the RAPsyn family. http://togogenome.org/gene/31033:LOC101061022 ^@ http://purl.uniprot.org/uniprot/H2UWB4 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/31033:LOC101074181 ^@ http://purl.uniprot.org/uniprot/A0A3B5KCR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:sfrp5 ^@ http://purl.uniprot.org/uniprot/A0A3B5K2E6 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:tspo ^@ http://purl.uniprot.org/uniprot/A0A674MEV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/31033:hoxd9 ^@ http://purl.uniprot.org/uniprot/Q1KKS9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:nudc ^@ http://purl.uniprot.org/uniprot/H2U0J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudC family.|||Midbody|||spindle http://togogenome.org/gene/31033:rpl32 ^@ http://purl.uniprot.org/uniprot/A0A3B5KRF6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/31033:slc10a7 ^@ http://purl.uniprot.org/uniprot/H2V6L0|||http://purl.uniprot.org/uniprot/H2V6L1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Cell membrane|||Does not show transport activity towards bile acids or steroid sulfates.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/31033:gatc ^@ http://purl.uniprot.org/uniprot/A0A674PHV3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/31033:LOC101061965 ^@ http://purl.uniprot.org/uniprot/A0A674PNK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/31033:LOC101070560 ^@ http://purl.uniprot.org/uniprot/H2RPW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101073316 ^@ http://purl.uniprot.org/uniprot/H2TCV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.|||Endomembrane system http://togogenome.org/gene/31033:LOC101068809 ^@ http://purl.uniprot.org/uniprot/H2VAQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Cell membrane|||Cleavage furrow|||Endosome membrane|||Midbody ring|||Recycling endosome membrane|||filopodium membrane|||ruffle http://togogenome.org/gene/31033:bmt2 ^@ http://purl.uniprot.org/uniprot/H2UXC4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the BMT2 family.|||Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.|||S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/31033:naa10 ^@ http://purl.uniprot.org/uniprot/A0A674MW43 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/31033:LOC101066672 ^@ http://purl.uniprot.org/uniprot/A0A674MK41 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:LOC101062999 ^@ http://purl.uniprot.org/uniprot/H2V2B9 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/31033:LOC101071822 ^@ http://purl.uniprot.org/uniprot/A0A3B5K6G0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family.|||Cytoplasm|||May contribute to the regulation of cell proliferation.|||Mitochondrion|||Monomer and homodimer.|||Nucleus http://togogenome.org/gene/31033:LOC101067257 ^@ http://purl.uniprot.org/uniprot/H2TJG5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/31033:LOC101063230 ^@ http://purl.uniprot.org/uniprot/A0A3B5KKN5 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/31033:LOC101067638 ^@ http://purl.uniprot.org/uniprot/A0A674PNU4 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/31033:atp1b3 ^@ http://purl.uniprot.org/uniprot/A0A674PJH6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/31033:LOC101076719 ^@ http://purl.uniprot.org/uniprot/A0A674PN53 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:id3 ^@ http://purl.uniprot.org/uniprot/H2TZ42 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:rpl10a ^@ http://purl.uniprot.org/uniprot/H2UWL3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL1 family. http://togogenome.org/gene/31033:srrd ^@ http://purl.uniprot.org/uniprot/H2UXX1 ^@ Similarity ^@ Belongs to the SRR1 family. http://togogenome.org/gene/31033:myo1e ^@ http://purl.uniprot.org/uniprot/H2V897 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/31033:atp6v1d ^@ http://purl.uniprot.org/uniprot/A0A3B5K8V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase D subunit family.|||clathrin-coated vesicle membrane http://togogenome.org/gene/31033:LOC101071192 ^@ http://purl.uniprot.org/uniprot/H2TMK3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:atp10d ^@ http://purl.uniprot.org/uniprot/H2SCQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/31033:ube4a ^@ http://purl.uniprot.org/uniprot/H2UR99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101077798 ^@ http://purl.uniprot.org/uniprot/A0A674PH28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:ddx6 ^@ http://purl.uniprot.org/uniprot/A0A3B5KEL6 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/31033:nlgn3b ^@ http://purl.uniprot.org/uniprot/D2X2H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101065699 ^@ http://purl.uniprot.org/uniprot/A0A3B5KQ92 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101066890 ^@ http://purl.uniprot.org/uniprot/H2U376 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:syngr3 ^@ http://purl.uniprot.org/uniprot/H2RVU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/31033:acvr1b ^@ http://purl.uniprot.org/uniprot/A0A3B5K7U3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/31033:ctdp1 ^@ http://purl.uniprot.org/uniprot/A0A674PMH1|||http://purl.uniprot.org/uniprot/H2U7R2 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||This promotes the activity of RNA polymerase II. http://togogenome.org/gene/31033:arf3 ^@ http://purl.uniprot.org/uniprot/P61207 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/31033:grb2 ^@ http://purl.uniprot.org/uniprot/H2T7L9 ^@ Subcellular Location Annotation ^@ Endosome|||Golgi apparatus|||Nucleus http://togogenome.org/gene/31033:LOC101076629 ^@ http://purl.uniprot.org/uniprot/H2T1Y8 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/31033:cxcr5 ^@ http://purl.uniprot.org/uniprot/F1SWA9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:arl5a ^@ http://purl.uniprot.org/uniprot/H2UK67 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/31033:mmachc ^@ http://purl.uniprot.org/uniprot/H2VDC2 ^@ Similarity ^@ Belongs to the MMACHC family. http://togogenome.org/gene/31033:phpt1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K405 ^@ Function|||Similarity ^@ Belongs to the janus family.|||Exhibits phosphohistidine phosphatase activity. http://togogenome.org/gene/31033:zdhhc9 ^@ http://purl.uniprot.org/uniprot/H2TW56 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/31033:LOC101072941 ^@ http://purl.uniprot.org/uniprot/H2UH85 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POMC family.|||Secreted|||Stimulates the adrenal glands to release cortisol. http://togogenome.org/gene/31033:med6 ^@ http://purl.uniprot.org/uniprot/H2TYG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 6 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/31033:LOC101064798 ^@ http://purl.uniprot.org/uniprot/A0A674PEN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:wnt8 ^@ http://purl.uniprot.org/uniprot/Q6E0H1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/31033:masp2 ^@ http://purl.uniprot.org/uniprot/A0A3B5K7B7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:blmh ^@ http://purl.uniprot.org/uniprot/H2TBG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Cytoplasm http://togogenome.org/gene/31033:eftud2 ^@ http://purl.uniprot.org/uniprot/H2UYE7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:smo ^@ http://purl.uniprot.org/uniprot/A0A674PB40 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||cilium http://togogenome.org/gene/31033:serinc5 ^@ http://purl.uniprot.org/uniprot/H2TJX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/31033:LOC101068133 ^@ http://purl.uniprot.org/uniprot/H2TDW3 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 56 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:ddx5 ^@ http://purl.uniprot.org/uniprot/H2RZ56 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/31033:LOC101077924 ^@ http://purl.uniprot.org/uniprot/H2SLZ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GnRH family.|||Secreted|||Stimulates the secretion of gonadotropins. http://togogenome.org/gene/31033:mpeg1 ^@ http://purl.uniprot.org/uniprot/H2U6K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MPEG1 family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/31033:LOC101077879 ^@ http://purl.uniprot.org/uniprot/H2UUB5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:tas1r3 ^@ http://purl.uniprot.org/uniprot/Q2MHJ8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:gdpd1 ^@ http://purl.uniprot.org/uniprot/H2SZF7 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/31033:LOC101079855 ^@ http://purl.uniprot.org/uniprot/A0A674MQR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/31033:tmbim1 ^@ http://purl.uniprot.org/uniprot/H2TLA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/31033:LOC101071738 ^@ http://purl.uniprot.org/uniprot/A0A674PR36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFC2 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:LOC101072120 ^@ http://purl.uniprot.org/uniprot/H2TET8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/31033:mrpl47 ^@ http://purl.uniprot.org/uniprot/H2V7B6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/31033:pou3f4 ^@ http://purl.uniprot.org/uniprot/H2TCY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-3 subfamily.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:pln ^@ http://purl.uniprot.org/uniprot/A0A3B5KC38 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phospholamban family.|||Endoplasmic reticulum membrane|||Homopentamer.|||Membrane|||Mitochondrion membrane|||Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/31033:LOC101065833 ^@ http://purl.uniprot.org/uniprot/A0A3B5K7L3 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/31033:LOC101078250 ^@ http://purl.uniprot.org/uniprot/A0A674NW52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:slc12a1 ^@ http://purl.uniprot.org/uniprot/A0A674NVT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/31033:pomt1 ^@ http://purl.uniprot.org/uniprot/A0A674P618 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/31033:LOC101069277 ^@ http://purl.uniprot.org/uniprot/A0A674MHB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Recycling endosome|||phagosome|||trans-Golgi network membrane http://togogenome.org/gene/31033:rhag ^@ http://purl.uniprot.org/uniprot/Q4VV03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Cell membrane|||Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.|||Membrane http://togogenome.org/gene/31033:kcng1 ^@ http://purl.uniprot.org/uniprot/H2ST45 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101063986 ^@ http://purl.uniprot.org/uniprot/A0A674MQR5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/31033:trmt6 ^@ http://purl.uniprot.org/uniprot/A0A674PDM5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM6/GCD10 family.|||Heterotetramer.|||Nucleus|||Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. http://togogenome.org/gene/31033:snrpc ^@ http://purl.uniprot.org/uniprot/A0A674NDW4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U1 small nuclear ribonucleoprotein C family.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Nucleus|||U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. http://togogenome.org/gene/31033:LOC101077487 ^@ http://purl.uniprot.org/uniprot/A0A3B5K954 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:LOC101078603 ^@ http://purl.uniprot.org/uniprot/H2S9M5 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/31033:LOC101066520 ^@ http://purl.uniprot.org/uniprot/H2U4H2 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/31033:pacs1 ^@ http://purl.uniprot.org/uniprot/H2SZB6 ^@ Similarity ^@ Belongs to the PACS family. http://togogenome.org/gene/31033:sbf1 ^@ http://purl.uniprot.org/uniprot/A0A674MZF6 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/31033:c12h1orf43 ^@ http://purl.uniprot.org/uniprot/H2TN66 ^@ Function|||Subcellular Location Annotation ^@ General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.|||Golgi apparatus|||Membrane|||Mitochondrion http://togogenome.org/gene/31033:LOC101063004 ^@ http://purl.uniprot.org/uniprot/H2UAX9 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasmic vesicle membrane|||Interacts with ARF6.|||Membrane|||Presynapse http://togogenome.org/gene/31033:LOC101062110 ^@ http://purl.uniprot.org/uniprot/H2V282 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/31033:LOC101072391 ^@ http://purl.uniprot.org/uniprot/A0A3B5KP99 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:LOC101073860 ^@ http://purl.uniprot.org/uniprot/A0A674N2C7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/31033:slc14a1 ^@ http://purl.uniprot.org/uniprot/Q5W8V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urea transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:uhrf2 ^@ http://purl.uniprot.org/uniprot/H2UJY8 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.|||Nucleus|||The YDG domain mediates the interaction with histone H3.|||The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3). http://togogenome.org/gene/31033:LOC101066755 ^@ http://purl.uniprot.org/uniprot/H2SQE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/31033:rps9 ^@ http://purl.uniprot.org/uniprot/H2UUL1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/31033:hapln2 ^@ http://purl.uniprot.org/uniprot/H2SQ78 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101066121 ^@ http://purl.uniprot.org/uniprot/H2T8N8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/31033:LOC101062167 ^@ http://purl.uniprot.org/uniprot/Q1KKX5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:KEF89_p09 ^@ http://purl.uniprot.org/uniprot/Q8HCW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase protein 8 family.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/31033:lyar ^@ http://purl.uniprot.org/uniprot/H2UHR1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:rps16 ^@ http://purl.uniprot.org/uniprot/A0A674MJE9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/31033:LOC101076531 ^@ http://purl.uniprot.org/uniprot/A0A674NYQ1 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/31033:adgrl4 ^@ http://purl.uniprot.org/uniprot/A0A674NR19 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:LOC101063161 ^@ http://purl.uniprot.org/uniprot/H2SUR8 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/31033:cnot11 ^@ http://purl.uniprot.org/uniprot/H2V2F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT11 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:gpsm1 ^@ http://purl.uniprot.org/uniprot/H2SXN9 ^@ Similarity ^@ Belongs to the GPSM family. http://togogenome.org/gene/31033:sf3b1 ^@ http://purl.uniprot.org/uniprot/H2URZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B1 family.|||Nucleus http://togogenome.org/gene/31033:mrpl35 ^@ http://purl.uniprot.org/uniprot/A0A674N792 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bL35 family.|||Mitochondrion http://togogenome.org/gene/31033:hoxc9 ^@ http://purl.uniprot.org/uniprot/O42502 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101077566 ^@ http://purl.uniprot.org/uniprot/H2S7D0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP2 family.|||Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.|||Membrane http://togogenome.org/gene/31033:LOC101069891 ^@ http://purl.uniprot.org/uniprot/A0A674PAM9 ^@ Similarity ^@ Belongs to the PRORSD1 family. http://togogenome.org/gene/31033:nkx3-2 ^@ http://purl.uniprot.org/uniprot/H2UJ02 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101071146 ^@ http://purl.uniprot.org/uniprot/Q8QFS1 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/31033:LOC101073007 ^@ http://purl.uniprot.org/uniprot/H2UJH4 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/31033:LOC101068604 ^@ http://purl.uniprot.org/uniprot/A0A674MKB0 ^@ Similarity ^@ Belongs to the glutaminase family. http://togogenome.org/gene/31033:LOC101062822 ^@ http://purl.uniprot.org/uniprot/A0A674MZ83 ^@ Function|||Similarity ^@ Belongs to the troponin T family.|||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/31033:LOC101067404 ^@ http://purl.uniprot.org/uniprot/H2S5F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/31033:LOC101072048 ^@ http://purl.uniprot.org/uniprot/H2SYS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/31033:LOC101080185 ^@ http://purl.uniprot.org/uniprot/H2TKX0 ^@ Similarity ^@ Belongs to the peptidase M24 family. http://togogenome.org/gene/31033:c21h12orf43 ^@ http://purl.uniprot.org/uniprot/A0A3B5KF23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUSTOS family.|||Nucleus envelope http://togogenome.org/gene/31033:LOC101068751 ^@ http://purl.uniprot.org/uniprot/H2UDT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101071216 ^@ http://purl.uniprot.org/uniprot/H2TU30 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/31033:LOC101067977 ^@ http://purl.uniprot.org/uniprot/A0A3B5JXM2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex.|||In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.|||Nucleus http://togogenome.org/gene/31033:ethe1 ^@ http://purl.uniprot.org/uniprot/H2THE1 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/31033:LOC101078847 ^@ http://purl.uniprot.org/uniprot/H2TNP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphatidyl serine synthase family.|||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:asah1 ^@ http://purl.uniprot.org/uniprot/Q8JG45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acid ceramidase family.|||Lysosome http://togogenome.org/gene/31033:dlx5 ^@ http://purl.uniprot.org/uniprot/A0A3B5KF60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:wdr83os ^@ http://purl.uniprot.org/uniprot/A0A674N8N0 ^@ Similarity ^@ Belongs to the Asterix family. http://togogenome.org/gene/31033:LOC101067019 ^@ http://purl.uniprot.org/uniprot/A0A674MUD3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-7 family.|||Cell junction|||Cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. http://togogenome.org/gene/31033:ints12 ^@ http://purl.uniprot.org/uniprot/H2SKT5 ^@ Similarity ^@ Belongs to the Integrator subunit 12 family. http://togogenome.org/gene/31033:alg3 ^@ http://purl.uniprot.org/uniprot/H2UHT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.|||Belongs to the glycosyltransferase 58 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:cd28 ^@ http://purl.uniprot.org/uniprot/A1L4S4|||http://purl.uniprot.org/uniprot/H2T9J0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:evc ^@ http://purl.uniprot.org/uniprot/Q671A1 ^@ Subcellular Location Annotation ^@ Membrane|||cilium basal body|||cilium membrane http://togogenome.org/gene/31033:ipo4 ^@ http://purl.uniprot.org/uniprot/A0A674NAB2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:phf8 ^@ http://purl.uniprot.org/uniprot/A0A674PKK8 ^@ Similarity ^@ Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. http://togogenome.org/gene/31033:ptp4a1 ^@ http://purl.uniprot.org/uniprot/A0A674NEG1 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/31033:LOC101070983 ^@ http://purl.uniprot.org/uniprot/H2S4Z2 ^@ Similarity|||Subunit ^@ Belongs to the 14-3-3 family.|||Homodimer, and heterodimer with other family members. http://togogenome.org/gene/31033:taf6 ^@ http://purl.uniprot.org/uniprot/H2UYT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF6 family.|||Nucleus http://togogenome.org/gene/31033:adora2a ^@ http://purl.uniprot.org/uniprot/A0A674MC46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/31033:xrg5 ^@ http://purl.uniprot.org/uniprot/Q5GH50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/31033:med16 ^@ http://purl.uniprot.org/uniprot/H2T4D7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 16 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/31033:spg7 ^@ http://purl.uniprot.org/uniprot/H2V4S3 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/31033:LOC101068178 ^@ http://purl.uniprot.org/uniprot/A0A674PCC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:trpt1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KDI8 ^@ Function|||Similarity ^@ Belongs to the KptA/TPT1 family.|||Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate. http://togogenome.org/gene/31033:ddb2 ^@ http://purl.uniprot.org/uniprot/H2UPZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DDB2/WDR76 family.|||Nucleus http://togogenome.org/gene/31033:pitx1 ^@ http://purl.uniprot.org/uniprot/A0A674PJ71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101062359 ^@ http://purl.uniprot.org/uniprot/A0A674M9Y9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:prkg2 ^@ http://purl.uniprot.org/uniprot/A0A674PQD6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. http://togogenome.org/gene/31033:LOC101070601 ^@ http://purl.uniprot.org/uniprot/A0A674MBW3 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/31033:LOC101073247 ^@ http://purl.uniprot.org/uniprot/H2UPV0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Monomer. Homodimer; disulfide-linked.|||Secreted|||The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.|||The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.|||The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. http://togogenome.org/gene/31033:fuz ^@ http://purl.uniprot.org/uniprot/A0A674P9D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fuzzy family.|||cytoskeleton http://togogenome.org/gene/31033:cyfip1 ^@ http://purl.uniprot.org/uniprot/H2TIQ5 ^@ Similarity ^@ Belongs to the CYFIP family. http://togogenome.org/gene/31033:KEF89_p06 ^@ http://purl.uniprot.org/uniprot/Q8HCV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 3 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.|||Mitochondrion membrane http://togogenome.org/gene/31033:LOC101064911 ^@ http://purl.uniprot.org/uniprot/A0A3B5KTD4 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/31033:pparg ^@ http://purl.uniprot.org/uniprot/A4PE14 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Cytoplasm|||Heterodimer with other nuclear receptors.|||Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.|||Nucleus http://togogenome.org/gene/31033:pgp ^@ http://purl.uniprot.org/uniprot/A0A674PQW5 ^@ Cofactor|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||Divalent metal ions. Mg(2+) is the most effective. http://togogenome.org/gene/31033:ext2 ^@ http://purl.uniprot.org/uniprot/H2V525 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/31033:LOC105417514 ^@ http://purl.uniprot.org/uniprot/A0A3B5KH97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/31033:ap3s1 ^@ http://purl.uniprot.org/uniprot/H2V0X1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Membrane|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. http://togogenome.org/gene/31033:gpatch11 ^@ http://purl.uniprot.org/uniprot/A0A3B5JVA1 ^@ Similarity ^@ Belongs to the GPATCH11 family. http://togogenome.org/gene/31033:satb2 ^@ http://purl.uniprot.org/uniprot/H2UQV0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101061652 ^@ http://purl.uniprot.org/uniprot/A0A3B5KEI5 ^@ Similarity|||Subunit ^@ Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.|||Homotetramer. http://togogenome.org/gene/31033:pank4 ^@ http://purl.uniprot.org/uniprot/A0A674NLL5 ^@ Similarity|||Subunit ^@ Belongs to the type II pantothenate kinase family.|||Homodimer. Interacts with PKM.|||In the N-terminal section; belongs to the type II pantothenate kinase family. http://togogenome.org/gene/31033:gas6 ^@ http://purl.uniprot.org/uniprot/H2V4I6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:dll4 ^@ http://purl.uniprot.org/uniprot/H2U7H0 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/31033:odr4 ^@ http://purl.uniprot.org/uniprot/A0A3B5KSD6 ^@ Function|||Similarity ^@ Belongs to the ODR-4 family.|||May play a role in the trafficking of a subset of G-protein coupled receptors. http://togogenome.org/gene/31033:tafa1 ^@ http://purl.uniprot.org/uniprot/H2SRM6 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/31033:LOC101067486 ^@ http://purl.uniprot.org/uniprot/H2TIB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/31033:timp-2b ^@ http://purl.uniprot.org/uniprot/Q4JF89 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/31033:th ^@ http://purl.uniprot.org/uniprot/A0JGX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.|||axon|||perinuclear region http://togogenome.org/gene/31033:LOC101076573 ^@ http://purl.uniprot.org/uniprot/H2UDP7 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/31033:necap2 ^@ http://purl.uniprot.org/uniprot/H2TPR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/31033:camsap1 ^@ http://purl.uniprot.org/uniprot/H2UZN3 ^@ Domain|||Similarity ^@ Belongs to the CAMSAP1 family.|||The CKK domain binds microtubules. http://togogenome.org/gene/31033:lrrc8c ^@ http://purl.uniprot.org/uniprot/H2U6A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101072056 ^@ http://purl.uniprot.org/uniprot/H2UFP4 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/31033:ncoa2 ^@ http://purl.uniprot.org/uniprot/A0A674PAS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/31033:il17d ^@ http://purl.uniprot.org/uniprot/D4AHP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/31033:ctbp2 ^@ http://purl.uniprot.org/uniprot/H2TGD1|||http://purl.uniprot.org/uniprot/H2TGD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/31033:LOC101073636 ^@ http://purl.uniprot.org/uniprot/A0A674NZA0 ^@ Similarity ^@ Belongs to the NAD kinase family. http://togogenome.org/gene/31033:LOC101062380 ^@ http://purl.uniprot.org/uniprot/A0A674NR87 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/31033:irf6 ^@ http://purl.uniprot.org/uniprot/H2SXC8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:srd5a1 ^@ http://purl.uniprot.org/uniprot/H2U0S4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.|||Membrane|||Microsome membrane http://togogenome.org/gene/31033:LOC101063453 ^@ http://purl.uniprot.org/uniprot/A0A674PBH9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC778023 ^@ http://purl.uniprot.org/uniprot/H2UJ85|||http://purl.uniprot.org/uniprot/Q14DX7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:cfap299 ^@ http://purl.uniprot.org/uniprot/A0A3B5KC60 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in spermatogenesis.|||Nucleus http://togogenome.org/gene/31033:LOC101068793 ^@ http://purl.uniprot.org/uniprot/A0A674MHH2 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.|||Nucleus http://togogenome.org/gene/31033:cpox ^@ http://purl.uniprot.org/uniprot/A0A3B5K803 ^@ Similarity|||Subunit ^@ Belongs to the aerobic coproporphyrinogen-III oxidase family.|||Homodimer. http://togogenome.org/gene/31033:pola1 ^@ http://purl.uniprot.org/uniprot/H2T555 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/31033:coq2 ^@ http://purl.uniprot.org/uniprot/H2V1S6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:coq5 ^@ http://purl.uniprot.org/uniprot/H2UWF2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).|||Mitochondrion inner membrane http://togogenome.org/gene/31033:LOC101064444 ^@ http://purl.uniprot.org/uniprot/H2ST97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/31033:fgd4 ^@ http://purl.uniprot.org/uniprot/A0A674MFG5|||http://purl.uniprot.org/uniprot/A0A674NH22 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/31033:ipmk ^@ http://purl.uniprot.org/uniprot/A0A674PPM2 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/31033:tspan6 ^@ http://purl.uniprot.org/uniprot/H2U084 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/31033:cd8beta ^@ http://purl.uniprot.org/uniprot/A7VKB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101063787 ^@ http://purl.uniprot.org/uniprot/H2T742 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/31033:cldn3a ^@ http://purl.uniprot.org/uniprot/Q6E5R0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:ndufb4 ^@ http://purl.uniprot.org/uniprot/A0A674MFB8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB4 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:LOC101076886 ^@ http://purl.uniprot.org/uniprot/A0A3B5KSL1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101078191 ^@ http://purl.uniprot.org/uniprot/A0A674NKY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SYG1 (TC 2.A.94) family.|||Membrane http://togogenome.org/gene/31033:LOC101074205 ^@ http://purl.uniprot.org/uniprot/H2TEA4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/31033:gsx1 ^@ http://purl.uniprot.org/uniprot/H2V244 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101066662 ^@ http://purl.uniprot.org/uniprot/A0A674P199 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:fzd8 ^@ http://purl.uniprot.org/uniprot/A0A3B5JW14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Membrane http://togogenome.org/gene/31033:LOC101074053 ^@ http://purl.uniprot.org/uniprot/A0A674MK50 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/31033:LOC101062439 ^@ http://purl.uniprot.org/uniprot/A0A674N7E2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/31033:rplp2 ^@ http://purl.uniprot.org/uniprot/A0A3B5K0K7 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/31033:LOC101074874 ^@ http://purl.uniprot.org/uniprot/H2RT29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/31033:park7 ^@ http://purl.uniprot.org/uniprot/A0A3B5KKN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C56 family.|||Membrane raft http://togogenome.org/gene/31033:rflnb ^@ http://purl.uniprot.org/uniprot/H2UXI8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Refilin family.|||Interacts with FLNA and FLNB.|||cytoskeleton http://togogenome.org/gene/31033:LOC101070734 ^@ http://purl.uniprot.org/uniprot/H2UR47 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic diacylglycerol kinase family.|||Monomer. http://togogenome.org/gene/31033:LOC101072989 ^@ http://purl.uniprot.org/uniprot/Q1KKX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:psma3 ^@ http://purl.uniprot.org/uniprot/H2T892 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/31033:ctsd2 ^@ http://purl.uniprot.org/uniprot/Q5TLU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Lysosome http://togogenome.org/gene/31033:ldlrad3 ^@ http://purl.uniprot.org/uniprot/H2TXQ8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101079890 ^@ http://purl.uniprot.org/uniprot/A0A3B5K140 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/31033:nprl3 ^@ http://purl.uniprot.org/uniprot/A0A674NCV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.|||Belongs to the NPR3 family.|||Lysosome http://togogenome.org/gene/31033:LOC101079834 ^@ http://purl.uniprot.org/uniprot/A0A3B5JYD4 ^@ Similarity ^@ Belongs to the CARF family. http://togogenome.org/gene/31033:LOC101074720 ^@ http://purl.uniprot.org/uniprot/H2UH33 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.|||Nucleus http://togogenome.org/gene/31033:LOC101068538 ^@ http://purl.uniprot.org/uniprot/A0A3B5KMN0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:churc1 ^@ http://purl.uniprot.org/uniprot/H2VAT4 ^@ Similarity ^@ Belongs to the Churchill family. http://togogenome.org/gene/31033:vkorc1l1 ^@ http://purl.uniprot.org/uniprot/Q6TEK8 ^@ Activity Regulation|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VKOR family.|||Endoplasmic reticulum membrane|||Inhibited by warfarin (coumadin) (PubMed:33154105). Warfarin locks VKORC1 in both redox states into the closed conformation (PubMed:33154105).|||Involved in vitamin K metabolism (PubMed:33154105). Can reduce inactive vitamin K 2,3-epoxide to active vitamin K, and may contribute to vitamin K-mediated protection against oxidative stress (PubMed:33154105). Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins (By similarity).|||Partially oxidized VKORC1 forms a cysteine adduct with substrates, vitamin K 2,3-epoxide, inducing a closed conformation, juxtaposing all cysteines (S-S or SH) for unimpeded electron transfer (PubMed:33154105). VKOR becomes fully oxidized with an open conformation that releases reaction products, vitamin K quinone, or hydroquinone (PubMed:33154105). Cys-138 and Cys-141 constitute the catalytic redox-active center (PubMed:33154105). Cys-49 and Cys-57 are the cysteine pair that mediates transfer of reducing equivalents during catalysis (PubMed:33154105). http://togogenome.org/gene/31033:LOC101077641 ^@ http://purl.uniprot.org/uniprot/H2UGJ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SOSS-C family.|||Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).|||Component of the SOSS complex.|||Nucleus http://togogenome.org/gene/31033:mras ^@ http://purl.uniprot.org/uniprot/H2SP11 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/31033:fam126a ^@ http://purl.uniprot.org/uniprot/H2TBH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/31033:LOC101066144 ^@ http://purl.uniprot.org/uniprot/A0A3B5KHZ2 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/31033:phox2a ^@ http://purl.uniprot.org/uniprot/H2TJR0 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:arl2 ^@ http://purl.uniprot.org/uniprot/H2SKW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/31033:LOC101064246 ^@ http://purl.uniprot.org/uniprot/H2S2P8 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/31033:LOC101065268 ^@ http://purl.uniprot.org/uniprot/A0A3B5KCV8 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/31033:serp1 ^@ http://purl.uniprot.org/uniprot/H2VAC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAMP4 family.|||Endoplasmic reticulum membrane|||May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.|||Membrane http://togogenome.org/gene/31033:LOC101080230 ^@ http://purl.uniprot.org/uniprot/A0A3B5KIW1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:nkd1 ^@ http://purl.uniprot.org/uniprot/H2T7P1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NKD family.|||Cell autonomous antagonist of the canonical Wnt signaling pathway.|||Cell membrane|||Cytoplasm http://togogenome.org/gene/31033:phox2b ^@ http://purl.uniprot.org/uniprot/H2T173 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101070807 ^@ http://purl.uniprot.org/uniprot/A0A3B5K9I3 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/31033:LOC101069286 ^@ http://purl.uniprot.org/uniprot/A0A674MZT5 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/31033:arl2bp ^@ http://purl.uniprot.org/uniprot/A0A3B5KEG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARL2BP family.|||Cytoplasm|||Mitochondrion intermembrane space|||Nucleus|||Plays a role as an effector of the ADP-ribosylation factor-like protein 2, ARL2.|||centrosome|||cilium basal body http://togogenome.org/gene/31033:cdc37l1 ^@ http://purl.uniprot.org/uniprot/A0A674P4K1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101068014 ^@ http://purl.uniprot.org/uniprot/Q1KL11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Proboscipedia subfamily.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:cldn31 ^@ http://purl.uniprot.org/uniprot/Q6E5T6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:rpl4 ^@ http://purl.uniprot.org/uniprot/H2UKK2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/31033:LOC101063456 ^@ http://purl.uniprot.org/uniprot/A0A3B5KGI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/31033:cwf19l1 ^@ http://purl.uniprot.org/uniprot/H2SMS1 ^@ Similarity ^@ Belongs to the CWF19 family. http://togogenome.org/gene/31033:nkx2-8 ^@ http://purl.uniprot.org/uniprot/Q9DDW2 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:f9 ^@ http://purl.uniprot.org/uniprot/H2T095|||http://purl.uniprot.org/uniprot/Q804W8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular space http://togogenome.org/gene/31033:fgc6ast1 ^@ http://purl.uniprot.org/uniprot/Q14TH3 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101069611 ^@ http://purl.uniprot.org/uniprot/Q1KL22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:eloc ^@ http://purl.uniprot.org/uniprot/A0A674P5J1 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/31033:tor3a ^@ http://purl.uniprot.org/uniprot/H2SHJ6 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. Torsin subfamily. http://togogenome.org/gene/31033:LOC101076304 ^@ http://purl.uniprot.org/uniprot/H2UYN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/31033:LOC101070409 ^@ http://purl.uniprot.org/uniprot/H2RUY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:LOC101065852 ^@ http://purl.uniprot.org/uniprot/H2RVY7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). http://togogenome.org/gene/31033:cd3e ^@ http://purl.uniprot.org/uniprot/Q589Z2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101074767 ^@ http://purl.uniprot.org/uniprot/H2SQX5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101069967 ^@ http://purl.uniprot.org/uniprot/H2VEB2 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/31033:fam13c ^@ http://purl.uniprot.org/uniprot/A0A674MYR2 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/31033:ints10 ^@ http://purl.uniprot.org/uniprot/H2TIL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 10 family.|||Nucleus http://togogenome.org/gene/31033:LOC101079303 ^@ http://purl.uniprot.org/uniprot/H2V236 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:tspan15 ^@ http://purl.uniprot.org/uniprot/A0A3B5K392 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/31033:LOC101079018 ^@ http://purl.uniprot.org/uniprot/H2SSD7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:cers1 ^@ http://purl.uniprot.org/uniprot/H2TYB5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:fmnl3 ^@ http://purl.uniprot.org/uniprot/A0A674P3B3|||http://purl.uniprot.org/uniprot/A0A674PBJ9|||http://purl.uniprot.org/uniprot/H2TDE1 ^@ Similarity ^@ Belongs to the formin homology family. http://togogenome.org/gene/31033:tnfaip3 ^@ http://purl.uniprot.org/uniprot/A0A3B5JWY3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/31033:LOC101073683 ^@ http://purl.uniprot.org/uniprot/A0A3B5K1J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/31033:polr1a ^@ http://purl.uniprot.org/uniprot/H2RY49 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/31033:dusp16 ^@ http://purl.uniprot.org/uniprot/H2S5U9 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/31033:ddx54 ^@ http://purl.uniprot.org/uniprot/H2UMM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.|||nucleolus http://togogenome.org/gene/31033:LOC101069662 ^@ http://purl.uniprot.org/uniprot/H2TVH5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:LOC101067589 ^@ http://purl.uniprot.org/uniprot/H2S936 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.|||Cytoplasm http://togogenome.org/gene/31033:becn1 ^@ http://purl.uniprot.org/uniprot/Q4A1K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beclin family.|||Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Mitochondrion membrane|||autophagosome|||trans-Golgi network membrane http://togogenome.org/gene/31033:hspa5 ^@ http://purl.uniprot.org/uniprot/H2S609 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/31033:LOC101074923 ^@ http://purl.uniprot.org/uniprot/H2TGH0 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/31033:sirt5 ^@ http://purl.uniprot.org/uniprot/H2U3N7 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sirtuin family. Class III subfamily.|||Binds 1 zinc ion per subunit.|||In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-95 and Arg-98) that bind to malonylated and succinylated substrates and define the specificity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion|||NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.|||Nucleus|||cytosol http://togogenome.org/gene/31033:LOC101069507 ^@ http://purl.uniprot.org/uniprot/H2STT3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:eef1akmt1 ^@ http://purl.uniprot.org/uniprot/H2UU60 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.|||Cytoplasm|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.|||Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure. http://togogenome.org/gene/31033:tpm4 ^@ http://purl.uniprot.org/uniprot/Q805C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/31033:glo1 ^@ http://purl.uniprot.org/uniprot/A0A674MCW1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the glyoxalase I family.|||Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.|||Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. http://togogenome.org/gene/31033:map3k10 ^@ http://purl.uniprot.org/uniprot/A0A674N9U5 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Homodimer.|||Homodimerization via the leucine zipper domains is required for autophosphorylation. http://togogenome.org/gene/31033:cnmd ^@ http://purl.uniprot.org/uniprot/H2TFL7 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/31033:asip ^@ http://purl.uniprot.org/uniprot/A0ZSG4 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/31033:strada ^@ http://purl.uniprot.org/uniprot/H2TT06 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. http://togogenome.org/gene/31033:LOC101076071 ^@ http://purl.uniprot.org/uniprot/A0A3B5KKL5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC445980 ^@ http://purl.uniprot.org/uniprot/Q6KC06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/31033:rbm47 ^@ http://purl.uniprot.org/uniprot/A0A674NZN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM RBM47 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:prdm13 ^@ http://purl.uniprot.org/uniprot/H2RKU8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:ccn6 ^@ http://purl.uniprot.org/uniprot/A0A674P9Q1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/31033:LOC101079102 ^@ http://purl.uniprot.org/uniprot/H2SCU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/31033:usp13 ^@ http://purl.uniprot.org/uniprot/H2V7E3 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/31033:LOC101079604 ^@ http://purl.uniprot.org/uniprot/H2SFZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/31033:LOC101074463 ^@ http://purl.uniprot.org/uniprot/H2V406 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/31033:gjd2 ^@ http://purl.uniprot.org/uniprot/H2UIE6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/31033:frat2 ^@ http://purl.uniprot.org/uniprot/H2RXZ5 ^@ Similarity ^@ Belongs to the GSK-3-binding protein family. http://togogenome.org/gene/31033:LOC101073575 ^@ http://purl.uniprot.org/uniprot/H2V3V0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/31033:ism1 ^@ http://purl.uniprot.org/uniprot/H2RJY6 ^@ Similarity ^@ Belongs to the isthmin family. http://togogenome.org/gene/31033:dmrt2 ^@ http://purl.uniprot.org/uniprot/Q4AE31|||http://purl.uniprot.org/uniprot/Q90WM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/31033:LOC101063388 ^@ http://purl.uniprot.org/uniprot/H2SPM1 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/31033:sft2d3 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZX3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/31033:actn4 ^@ http://purl.uniprot.org/uniprot/A0A674PQ94 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/31033:nsfl1c ^@ http://purl.uniprot.org/uniprot/H2T4F4 ^@ Subcellular Location Annotation ^@ Golgi stack http://togogenome.org/gene/31033:kif4a ^@ http://purl.uniprot.org/uniprot/H2SBR3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/31033:grk6 ^@ http://purl.uniprot.org/uniprot/H2RQK6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/31033:paics ^@ http://purl.uniprot.org/uniprot/A0A674MC30 ^@ Similarity|||Subunit ^@ Homooctamer.|||In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.|||In the N-terminal section; belongs to the SAICAR synthetase family. http://togogenome.org/gene/31033:dctn5 ^@ http://purl.uniprot.org/uniprot/H2TI94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.|||cytoskeleton http://togogenome.org/gene/31033:LOC446015 ^@ http://purl.uniprot.org/uniprot/H2SSZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/31033:acta1a ^@ http://purl.uniprot.org/uniprot/P68140 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.|||Belongs to the actin family.|||In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.|||Methylated at His-75 by SETD3.|||Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.|||N-terminal cleavage of acetylated cysteine of intermediate muscle actin by ACTMAP.|||Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.|||Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.|||Predominantly expressed in skeletal muscle. Lower levels in heart.|||There are two different alpha-skeletal actins in Fugu rubripes.|||cytoskeleton http://togogenome.org/gene/31033:LOC101068693 ^@ http://purl.uniprot.org/uniprot/H2U9Q6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:tgf-beta1 ^@ http://purl.uniprot.org/uniprot/H2UV73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.|||extracellular matrix http://togogenome.org/gene/31033:atg3 ^@ http://purl.uniprot.org/uniprot/A0A674MKW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG3 family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101076498 ^@ http://purl.uniprot.org/uniprot/A0A674NIB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101071462 ^@ http://purl.uniprot.org/uniprot/H2U8H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:gadd45a ^@ http://purl.uniprot.org/uniprot/A0A674NVV9 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/31033:ncapg ^@ http://purl.uniprot.org/uniprot/H2UCZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND3 (condensin subunit 3) family.|||Chromosome http://togogenome.org/gene/31033:rap2b ^@ http://purl.uniprot.org/uniprot/H2UFE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/31033:LOC101064170 ^@ http://purl.uniprot.org/uniprot/H2SQR6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/31033:e2f3 ^@ http://purl.uniprot.org/uniprot/A0A3B5K1B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/31033:apoa-i ^@ http://purl.uniprot.org/uniprot/Q5KSU5 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/31033:LOC101078979 ^@ http://purl.uniprot.org/uniprot/H2UZV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.|||Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.|||Membrane|||This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. http://togogenome.org/gene/31033:il10 ^@ http://purl.uniprot.org/uniprot/Q802T4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/31033:LOC101080083 ^@ http://purl.uniprot.org/uniprot/A0A674PPM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SYG1 (TC 2.A.94) family.|||Membrane http://togogenome.org/gene/31033:igfbp6 ^@ http://purl.uniprot.org/uniprot/H2RP73 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/31033:LOC101077130 ^@ http://purl.uniprot.org/uniprot/H2UWP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/31033:LOC101067940 ^@ http://purl.uniprot.org/uniprot/H2RSH7 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/31033:cldn5b ^@ http://purl.uniprot.org/uniprot/Q6E5S6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:LOC101069022 ^@ http://purl.uniprot.org/uniprot/H2SYZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIP3 family.|||Membrane http://togogenome.org/gene/31033:LOC101077527 ^@ http://purl.uniprot.org/uniprot/H2SQ30 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||Cytoplasm|||Major role in the synthesis of nucleoside triphosphates other than ATP.|||Nucleus|||lamellipodium|||ruffle http://togogenome.org/gene/31033:LOC105418776 ^@ http://purl.uniprot.org/uniprot/A0A3B5KCE4 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/31033:fam20c1 ^@ http://purl.uniprot.org/uniprot/I7LRF4 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/31033:LOC101078790 ^@ http://purl.uniprot.org/uniprot/A0A674MSX0|||http://purl.uniprot.org/uniprot/H2UD12 ^@ Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family. http://togogenome.org/gene/31033:smg5 ^@ http://purl.uniprot.org/uniprot/H2U4I4 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays a role in nonsense-mediated mRNA decay. http://togogenome.org/gene/31033:LOC101074624 ^@ http://purl.uniprot.org/uniprot/H2SWM4 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/31033:LOC101079811 ^@ http://purl.uniprot.org/uniprot/H2SNP7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space http://togogenome.org/gene/31033:fam20c2 ^@ http://purl.uniprot.org/uniprot/I7LST7 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/31033:fam214b ^@ http://purl.uniprot.org/uniprot/H2SBG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATOS family.|||Nucleus http://togogenome.org/gene/31033:rtn8 ^@ http://purl.uniprot.org/uniprot/Q4G5W8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:LOC101071924 ^@ http://purl.uniprot.org/uniprot/H2S6K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WFIKKN family.|||Membrane|||Secreted http://togogenome.org/gene/31033:rab32 ^@ http://purl.uniprot.org/uniprot/H2TDE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/31033:LOC101069829 ^@ http://purl.uniprot.org/uniprot/A0A3B5K8T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tumor necrosis factor family.|||Membrane|||Secreted http://togogenome.org/gene/31033:LOC101064065 ^@ http://purl.uniprot.org/uniprot/H2SQL1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/31033:LOC101069334 ^@ http://purl.uniprot.org/uniprot/H2T288 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/31033:vegfa ^@ http://purl.uniprot.org/uniprot/A0A674MWJ2 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/31033:LOC101079149 ^@ http://purl.uniprot.org/uniprot/A0A3B5KGL3 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:abi2 ^@ http://purl.uniprot.org/uniprot/A0A674NMY8|||http://purl.uniprot.org/uniprot/H2TG76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/31033:pgap2 ^@ http://purl.uniprot.org/uniprot/H2SNG8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP2 family.|||Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.|||Membrane http://togogenome.org/gene/31033:LOC105418000 ^@ http://purl.uniprot.org/uniprot/A0A3B5KBA3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:tlr22 ^@ http://purl.uniprot.org/uniprot/A8QMS2|||http://purl.uniprot.org/uniprot/Q5H723 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/31033:LOC101066309 ^@ http://purl.uniprot.org/uniprot/H2SEP1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101063953 ^@ http://purl.uniprot.org/uniprot/A0A3B5K643 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/31033:LOC101063377 ^@ http://purl.uniprot.org/uniprot/H2UDZ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.|||May affect the rate of fibrils formation.|||extracellular matrix http://togogenome.org/gene/31033:jam2 ^@ http://purl.uniprot.org/uniprot/A0A674MW02|||http://purl.uniprot.org/uniprot/H2TN49 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:ptpn2 ^@ http://purl.uniprot.org/uniprot/H2U2M3 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. http://togogenome.org/gene/31033:LOC101071856 ^@ http://purl.uniprot.org/uniprot/A0A3B5K1M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/31033:ntsr1 ^@ http://purl.uniprot.org/uniprot/H2T747 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:eda ^@ http://purl.uniprot.org/uniprot/A0A3B5JZP9 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/31033:cope ^@ http://purl.uniprot.org/uniprot/H2TXY5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPE family.|||Cytoplasm|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/31033:sf3b4 ^@ http://purl.uniprot.org/uniprot/H2SE87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B4 family.|||Nucleus http://togogenome.org/gene/31033:LOC101063387 ^@ http://purl.uniprot.org/uniprot/A0A3B5KBM2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:LOC101076878 ^@ http://purl.uniprot.org/uniprot/H2TVR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/31033:LOC101061685 ^@ http://purl.uniprot.org/uniprot/H2SXZ9 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/31033:psmg2 ^@ http://purl.uniprot.org/uniprot/H2SS41 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PSMG2 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.|||Forms a heterodimer with PSMG1. http://togogenome.org/gene/31033:rab39b ^@ http://purl.uniprot.org/uniprot/A0A3B5KPK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:anp32a ^@ http://purl.uniprot.org/uniprot/A0A674P2H4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/31033:LOC101064651 ^@ http://purl.uniprot.org/uniprot/A0A3B5KKG3|||http://purl.uniprot.org/uniprot/H2UNM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/31033:LOC101072519 ^@ http://purl.uniprot.org/uniprot/A0A674PIA5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:slc16a1 ^@ http://purl.uniprot.org/uniprot/H2VBY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/31033:hhex ^@ http://purl.uniprot.org/uniprot/A0A674PHK2 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:ndufb7 ^@ http://purl.uniprot.org/uniprot/H2SEJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB7 subunit family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/31033:pskh1 ^@ http://purl.uniprot.org/uniprot/A0A674P795 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:anapc5 ^@ http://purl.uniprot.org/uniprot/H2UXX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC5 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||spindle http://togogenome.org/gene/31033:irf8 ^@ http://purl.uniprot.org/uniprot/H2VBL9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101079064 ^@ http://purl.uniprot.org/uniprot/H2TAN6 ^@ Similarity|||Subunit ^@ Belongs to the ENDOU family.|||Monomer. http://togogenome.org/gene/31033:mmp2 ^@ http://purl.uniprot.org/uniprot/Q4JF84 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||extracellular matrix http://togogenome.org/gene/31033:set ^@ http://purl.uniprot.org/uniprot/A0A674MQH5 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/31033:ahcyl1 ^@ http://purl.uniprot.org/uniprot/H2S9L1|||http://purl.uniprot.org/uniprot/H2TA78 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/31033:rps4x ^@ http://purl.uniprot.org/uniprot/A0A674NI39 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/31033:LOC101068319 ^@ http://purl.uniprot.org/uniprot/H2U541 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/31033:LOC101078303 ^@ http://purl.uniprot.org/uniprot/H2TFG7 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/31033:cnih4 ^@ http://purl.uniprot.org/uniprot/H2T280 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/31033:lztfl1 ^@ http://purl.uniprot.org/uniprot/H2T1G8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LZTFL1 family.|||Cytoplasm|||Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.|||Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking. http://togogenome.org/gene/31033:LOC101062757 ^@ http://purl.uniprot.org/uniprot/H2SPE5 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/31033:LOC101075190 ^@ http://purl.uniprot.org/uniprot/A0A3B5KDT6 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/31033:stam ^@ http://purl.uniprot.org/uniprot/H2TEE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane http://togogenome.org/gene/31033:LOC105417094 ^@ http://purl.uniprot.org/uniprot/A0A3B5KJT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF2BP family.|||Nucleus http://togogenome.org/gene/31033:mrps15 ^@ http://purl.uniprot.org/uniprot/H2TTT0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/31033:ntf3 ^@ http://purl.uniprot.org/uniprot/A0A3B5K9Q0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Secreted|||Seems to promote the survival of visceral and proprioceptive sensory neurons. http://togogenome.org/gene/31033:dpy19l4 ^@ http://purl.uniprot.org/uniprot/A0A674N859|||http://purl.uniprot.org/uniprot/H2SXA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/31033:LOC101073139 ^@ http://purl.uniprot.org/uniprot/H2TKD8 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/31033:LOC101076023 ^@ http://purl.uniprot.org/uniprot/H2TQJ6 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/31033:zfpl1 ^@ http://purl.uniprot.org/uniprot/H2RPJ3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZFPL1 family.|||Membrane|||Required for cis-Golgi integrity and efficient ER to Golgi transport.|||The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.|||cis-Golgi network membrane http://togogenome.org/gene/31033:evx2 ^@ http://purl.uniprot.org/uniprot/Q1KKT3 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:nampt ^@ http://purl.uniprot.org/uniprot/A0A674NXI2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAPRTase family.|||Cytoplasm|||Homodimer.|||Nucleus|||Secreted http://togogenome.org/gene/31033:glce ^@ http://purl.uniprot.org/uniprot/A0A3B5KTY5 ^@ Similarity ^@ Belongs to the D-glucuronyl C5-epimerase family. http://togogenome.org/gene/31033:LOC101069303 ^@ http://purl.uniprot.org/uniprot/A0A674M9Q7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAPT1 family.|||Membrane http://togogenome.org/gene/31033:LOC101069539 ^@ http://purl.uniprot.org/uniprot/A0A3B5JXG0 ^@ Similarity ^@ Belongs to the requiem/DPF family. http://togogenome.org/gene/31033:LOC101076515 ^@ http://purl.uniprot.org/uniprot/H2TH94 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101073509 ^@ http://purl.uniprot.org/uniprot/A0A3B5K2Q9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/31033:LOC101079139 ^@ http://purl.uniprot.org/uniprot/H2UQE2 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:mlf2 ^@ http://purl.uniprot.org/uniprot/H2T949 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLF family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101062552 ^@ http://purl.uniprot.org/uniprot/A0A674NR91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/31033:LOC777959 ^@ http://purl.uniprot.org/uniprot/Q5IRB0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked.|||Its primary function is the prevention of hypercalcemia. Upon release into the circulation, it lowers calcium transport by the gills, thereby reducing its rate of influx from the environment into the extracellular compartment. STC also stimulates phosphate reabsorption by renal proximal tubules. The consequence of this action is increased levels of plasma phosphate, which combines with excess calcium and promotes its disposal into bone and scales. http://togogenome.org/gene/31033:hdhd3 ^@ http://purl.uniprot.org/uniprot/A0A674PER4 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/31033:cachd1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KEN1 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/31033:ik ^@ http://purl.uniprot.org/uniprot/A0A674MZY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RED family.|||Nucleus http://togogenome.org/gene/31033:LOC101062777 ^@ http://purl.uniprot.org/uniprot/H2V2B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/31033:c9 ^@ http://purl.uniprot.org/uniprot/P79755 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complement C6/C7/C8/C9 family.|||Component of the membrane attack complex (MAC). About 20 C9 chains oligomerize to give rise to a huge beta-barrel that forms a 100 Angstrom diameter pore in target membranes.|||Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.|||Secreted|||Target cell membrane|||The structure of the human polymeric form indicates the existence of an additional disulfide bond compared to the mouse monomeric form. http://togogenome.org/gene/31033:urm1 ^@ http://purl.uniprot.org/uniprot/H2T9P0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.|||Belongs to the URM1 family.|||C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.|||Cytoplasm http://togogenome.org/gene/31033:sox11 ^@ http://purl.uniprot.org/uniprot/Q6WNT4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:wap65-2 ^@ http://purl.uniprot.org/uniprot/Q75UL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hemopexin family.|||Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.|||Secreted http://togogenome.org/gene/31033:shbg ^@ http://purl.uniprot.org/uniprot/H2U4E8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101062466 ^@ http://purl.uniprot.org/uniprot/H2SHS0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF beta-subunit/FixA family.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/31033:LOC101076370 ^@ http://purl.uniprot.org/uniprot/H2VBK0 ^@ Similarity ^@ Belongs to the NGF-beta family. http://togogenome.org/gene/31033:chst2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KJW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/31033:LOC101071166 ^@ http://purl.uniprot.org/uniprot/A0A674NY49 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101078133 ^@ http://purl.uniprot.org/uniprot/H2S227 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/31033:LOC101062617 ^@ http://purl.uniprot.org/uniprot/H2SWW8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/31033:LOC101073669 ^@ http://purl.uniprot.org/uniprot/A0A3B5K2H7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes small subunit family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. http://togogenome.org/gene/31033:ndrg3 ^@ http://purl.uniprot.org/uniprot/A0A674PF38|||http://purl.uniprot.org/uniprot/H2TQ50 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/31033:LOC101074582 ^@ http://purl.uniprot.org/uniprot/H2S4S3 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/31033:gchfr ^@ http://purl.uniprot.org/uniprot/A0A3B5KIQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GFRP family.|||Membrane|||Nucleus membrane|||cytosol http://togogenome.org/gene/31033:LOC101079933 ^@ http://purl.uniprot.org/uniprot/H2SE18 ^@ Similarity ^@ Belongs to the complex I 23 kDa subunit family. http://togogenome.org/gene/31033:dad1 ^@ http://purl.uniprot.org/uniprot/H2RM93 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAD/OST2 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/31033:l3hypdh ^@ http://purl.uniprot.org/uniprot/H2TCH7 ^@ Similarity ^@ Belongs to the proline racemase family. http://togogenome.org/gene/31033:c7h8orf37 ^@ http://purl.uniprot.org/uniprot/A0A674MUI6 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in photoreceptor outer segment disk morphogenesis.|||Photoreceptor inner segment http://togogenome.org/gene/31033:LOC101066176 ^@ http://purl.uniprot.org/uniprot/A0A674MB44 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.|||Belongs to the carbohydrate kinase PfkB family.|||Binds 3 Mg(2+) ions per subunit.|||Monomer.|||Nucleus http://togogenome.org/gene/31033:eif3d ^@ http://purl.uniprot.org/uniprot/H2T4N9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit D family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Cytoplasm|||The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.|||mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. http://togogenome.org/gene/31033:p2rx2 ^@ http://purl.uniprot.org/uniprot/H2UU74 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/31033:LOC101073008 ^@ http://purl.uniprot.org/uniprot/A0A3B5K051 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/31033:LOC105417758 ^@ http://purl.uniprot.org/uniprot/H2UYB5 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/31033:ctbs ^@ http://purl.uniprot.org/uniprot/H2V6F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 18 family.|||Lysosome http://togogenome.org/gene/31033:sh3bgrl3 ^@ http://purl.uniprot.org/uniprot/A0A674MR35 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/31033:LOC101061321 ^@ http://purl.uniprot.org/uniprot/H2U9B0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/31033:tsnax ^@ http://purl.uniprot.org/uniprot/Q8AUM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the translin family.|||Nucleus http://togogenome.org/gene/31033:grhl1 ^@ http://purl.uniprot.org/uniprot/H2UCZ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:sema4c ^@ http://purl.uniprot.org/uniprot/A0A6D2X7Y1 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:klhl40 ^@ http://purl.uniprot.org/uniprot/H2V745 ^@ Similarity|||Subcellular Location Annotation ^@ A band|||Belongs to the KLHL40 family.|||I band http://togogenome.org/gene/31033:meis1 ^@ http://purl.uniprot.org/uniprot/A0A674NP53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101065642 ^@ http://purl.uniprot.org/uniprot/H2UV55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/31033:LOC101072209 ^@ http://purl.uniprot.org/uniprot/H2SU43 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit beta family.|||Heterodimer of an alpha and a beta chain.|||Involved in gametogenesis and steroidogenesis.|||Secreted http://togogenome.org/gene/31033:LOC101061569 ^@ http://purl.uniprot.org/uniprot/H2T5X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:rfc4 ^@ http://purl.uniprot.org/uniprot/H2SLF6 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/31033:pan2 ^@ http://purl.uniprot.org/uniprot/H2UHN6 ^@ Activity Regulation|||Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C19 family. PAN2 subfamily.|||Binds 2 metal cations per subunit in the catalytic exonuclease domain.|||Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.|||Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.|||Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||P-body|||Positively regulated by the regulatory subunit PAN3.|||The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3. http://togogenome.org/gene/31033:atp5if1 ^@ http://purl.uniprot.org/uniprot/H2TBT1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase inhibitor family.|||Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.|||Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.|||Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.|||Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.|||Mitochondrion http://togogenome.org/gene/31033:LOC101075520 ^@ http://purl.uniprot.org/uniprot/A0A3B5JY74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/31033:mc4r ^@ http://purl.uniprot.org/uniprot/Q90VY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane http://togogenome.org/gene/31033:LOC101062942 ^@ http://purl.uniprot.org/uniprot/A0A674N379 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:eps8l2 ^@ http://purl.uniprot.org/uniprot/H2SLP7 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/31033:LOC101064470 ^@ http://purl.uniprot.org/uniprot/H2TSJ2 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/31033:LOC101072599 ^@ http://purl.uniprot.org/uniprot/A0A674PMB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 30 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/31033:atp23 ^@ http://purl.uniprot.org/uniprot/A0A3B5K2B9 ^@ Similarity ^@ Belongs to the peptidase M76 family. http://togogenome.org/gene/31033:hmgcll1 ^@ http://purl.uniprot.org/uniprot/A0A674PHU3 ^@ Similarity ^@ Belongs to the HMG-CoA lyase family. http://togogenome.org/gene/31033:LOC101071456 ^@ http://purl.uniprot.org/uniprot/H2UNH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/31033:LOC101079729 ^@ http://purl.uniprot.org/uniprot/A0A674N3D9 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/31033:snf8 ^@ http://purl.uniprot.org/uniprot/H2TYV4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SNF8 family.|||Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II). http://togogenome.org/gene/31033:sptlc2 ^@ http://purl.uniprot.org/uniprot/A0A674NTM7 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/31033:pomgnt2 ^@ http://purl.uniprot.org/uniprot/I6L6Z5|||http://purl.uniprot.org/uniprot/Q5NDE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 61 family.|||Endoplasmic reticulum membrane|||Membrane|||O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity). http://togogenome.org/gene/31033:mfsd14a ^@ http://purl.uniprot.org/uniprot/A0A674MDD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/31033:ywhaz ^@ http://purl.uniprot.org/uniprot/H2TYG6 ^@ Similarity|||Subunit ^@ Belongs to the 14-3-3 family.|||Homodimer, and heterodimer with other family members. http://togogenome.org/gene/31033:LOC101067287 ^@ http://purl.uniprot.org/uniprot/A0A674P2X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.|||Cytoplasm http://togogenome.org/gene/31033:slc9a8 ^@ http://purl.uniprot.org/uniprot/H2RU01 ^@ Similarity ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. http://togogenome.org/gene/31033:rap2c ^@ http://purl.uniprot.org/uniprot/A0A674N6S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/31033:nkx6-3 ^@ http://purl.uniprot.org/uniprot/A0A3B5KUC6 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101061397 ^@ http://purl.uniprot.org/uniprot/A0A3B5KVM6 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:kcnj8 ^@ http://purl.uniprot.org/uniprot/H2TK24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/31033:acvr1 ^@ http://purl.uniprot.org/uniprot/H2SXS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/31033:guk1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KFA7 ^@ Similarity ^@ Belongs to the guanylate kinase family. http://togogenome.org/gene/31033:hoxb2 ^@ http://purl.uniprot.org/uniprot/Q6IEI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Proboscipedia subfamily.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101074032 ^@ http://purl.uniprot.org/uniprot/H2TGT5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:akt1 ^@ http://purl.uniprot.org/uniprot/H2UBQ0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. http://togogenome.org/gene/31033:LOC101069763 ^@ http://purl.uniprot.org/uniprot/H2V773 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:snx17 ^@ http://purl.uniprot.org/uniprot/H2SZU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/31033:LOC101062122 ^@ http://purl.uniprot.org/uniprot/A0A3B5K2X3 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/31033:tsen15 ^@ http://purl.uniprot.org/uniprot/A0A3B5KG50 ^@ Similarity ^@ Belongs to the SEN15 family. http://togogenome.org/gene/31033:tmem234 ^@ http://purl.uniprot.org/uniprot/A0A674MGI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM234 family.|||Membrane http://togogenome.org/gene/31033:slain1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KHY8 ^@ Similarity ^@ Belongs to the SLAIN motif-containing family. http://togogenome.org/gene/31033:aptx ^@ http://purl.uniprot.org/uniprot/P61800 ^@ Domain|||Function|||Subcellular Location Annotation ^@ DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity).|||The C2H2-type zinc finger mediates DNA-binding.|||The HIT domain is required for enzymatic activity.|||The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide.|||nucleolus|||nucleoplasm http://togogenome.org/gene/31033:strn ^@ http://purl.uniprot.org/uniprot/H2SKF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat striatin family.|||Membrane http://togogenome.org/gene/31033:LOC101067363 ^@ http://purl.uniprot.org/uniprot/H2SX67 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/31033:hepacam2 ^@ http://purl.uniprot.org/uniprot/H2UP93 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101066013 ^@ http://purl.uniprot.org/uniprot/H2VAI5 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/31033:LOC101064646 ^@ http://purl.uniprot.org/uniprot/A0A3B5K642 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/31033:odf2 ^@ http://purl.uniprot.org/uniprot/H2SSA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ODF2 family.|||centrosome http://togogenome.org/gene/31033:slc25a25 ^@ http://purl.uniprot.org/uniprot/H2UCT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/31033:fut9 ^@ http://purl.uniprot.org/uniprot/Q70AH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/31033:camk2a ^@ http://purl.uniprot.org/uniprot/A0A674MG54 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/31033:smc1b ^@ http://purl.uniprot.org/uniprot/Q802S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/31033:LOC101076002 ^@ http://purl.uniprot.org/uniprot/A0A674P044 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/31033:fes ^@ http://purl.uniprot.org/uniprot/H2VAN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.|||cytoskeleton http://togogenome.org/gene/31033:nrtn ^@ http://purl.uniprot.org/uniprot/A0A674PIK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/31033:lgi2 ^@ http://purl.uniprot.org/uniprot/Q1EGJ9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/31033:LOC101066235 ^@ http://purl.uniprot.org/uniprot/Q6WNU2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101063088 ^@ http://purl.uniprot.org/uniprot/H2UYP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/31033:LOC101071046 ^@ http://purl.uniprot.org/uniprot/A0A3B5KLK6 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101064765 ^@ http://purl.uniprot.org/uniprot/A0A3B5JX42 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/31033:smad6 ^@ http://purl.uniprot.org/uniprot/A0A3B5KAY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:LOC101076944 ^@ http://purl.uniprot.org/uniprot/A0A3B5KGD9|||http://purl.uniprot.org/uniprot/A0A674NH81 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/31033:smim8 ^@ http://purl.uniprot.org/uniprot/A0A674NB22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM8 family.|||Membrane http://togogenome.org/gene/31033:LOC101068696 ^@ http://purl.uniprot.org/uniprot/Q9I8E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parathyroid hormone family.|||Secreted http://togogenome.org/gene/31033:fut7 ^@ http://purl.uniprot.org/uniprot/H2S0F8|||http://purl.uniprot.org/uniprot/Q70AH2|||http://purl.uniprot.org/uniprot/Q70AH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/31033:aff3 ^@ http://purl.uniprot.org/uniprot/A0A674MVP3 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/31033:psmc3ip ^@ http://purl.uniprot.org/uniprot/A0A674MF11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HOP2 family.|||Nucleus http://togogenome.org/gene/31033:LOC101078918 ^@ http://purl.uniprot.org/uniprot/H2TTV8 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/31033:cnnm1 ^@ http://purl.uniprot.org/uniprot/A0A097ZIH6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ACDP family.|||Cell membrane|||Membrane|||Metal transporter. http://togogenome.org/gene/31033:anapc11 ^@ http://purl.uniprot.org/uniprot/A0A674MX98 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/31033:bmp5 ^@ http://purl.uniprot.org/uniprot/H2UQZ9 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/31033:LOC101073451 ^@ http://purl.uniprot.org/uniprot/H2V196 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:lmbr1 ^@ http://purl.uniprot.org/uniprot/H2TMI6 ^@ Similarity ^@ Belongs to the LIMR family. http://togogenome.org/gene/31033:npy7r ^@ http://purl.uniprot.org/uniprot/A7XY85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101077341 ^@ http://purl.uniprot.org/uniprot/A0A3B5KEP2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:supt4h1 ^@ http://purl.uniprot.org/uniprot/A0A674NYQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT4 family.|||Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.|||Nucleus http://togogenome.org/gene/31033:apoa-iv1 ^@ http://purl.uniprot.org/uniprot/Q5KSU4 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/31033:LOC101079526 ^@ http://purl.uniprot.org/uniprot/A0A3B5KFS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/31033:LOC101062529 ^@ http://purl.uniprot.org/uniprot/A0A3B5KAZ8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/31033:LOC101073552 ^@ http://purl.uniprot.org/uniprot/A0A674MUE7 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/31033:rpl14 ^@ http://purl.uniprot.org/uniprot/Q98SE0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/31033:ywhaq ^@ http://purl.uniprot.org/uniprot/H2UDY6 ^@ Similarity|||Subunit ^@ Belongs to the 14-3-3 family.|||Homodimer, and heterodimer with other family members. http://togogenome.org/gene/31033:ncor1 ^@ http://purl.uniprot.org/uniprot/A0A674NUJ6 ^@ Similarity ^@ Belongs to the N-CoR nuclear receptor corepressors family. http://togogenome.org/gene/31033:LOC101066528 ^@ http://purl.uniprot.org/uniprot/H2RKG9 ^@ Similarity ^@ Belongs to the Niban family. http://togogenome.org/gene/31033:KEF89_p01 ^@ http://purl.uniprot.org/uniprot/Q8HCV3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome b family.|||Binds 2 heme groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/31033:LOC101079043 ^@ http://purl.uniprot.org/uniprot/H2TPQ8 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101070231 ^@ http://purl.uniprot.org/uniprot/H2UQM6 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/31033:emc3 ^@ http://purl.uniprot.org/uniprot/A0A674NM90 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC3 family.|||Component of the ER membrane protein complex (EMC).|||Membrane http://togogenome.org/gene/31033:LOC101066888 ^@ http://purl.uniprot.org/uniprot/A0A674MUG9|||http://purl.uniprot.org/uniprot/A0A674PD95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/31033:ufl1 ^@ http://purl.uniprot.org/uniprot/A0A674NM83 ^@ Similarity ^@ Belongs to the UFL1 family. http://togogenome.org/gene/31033:LOC101078774 ^@ http://purl.uniprot.org/uniprot/A0A3B5KGW3 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101064464 ^@ http://purl.uniprot.org/uniprot/H2TWW8 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/31033:pou4f3 ^@ http://purl.uniprot.org/uniprot/H2SDR5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101077202 ^@ http://purl.uniprot.org/uniprot/H2UU73 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:ube3d ^@ http://purl.uniprot.org/uniprot/A0A674P602 ^@ Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. http://togogenome.org/gene/31033:LOC101070779 ^@ http://purl.uniprot.org/uniprot/H2UTK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/31033:LOC101069670 ^@ http://purl.uniprot.org/uniprot/H2T0H5 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/31033:naa60 ^@ http://purl.uniprot.org/uniprot/A0A3B5KEJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA60 subfamily.|||Golgi apparatus membrane http://togogenome.org/gene/31033:selenok ^@ http://purl.uniprot.org/uniprot/H2SUL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the selenoprotein K family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/31033:rflna ^@ http://purl.uniprot.org/uniprot/A0A674PRQ8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Refilin family.|||Interacts with FLNA and FLNB.|||cytoskeleton http://togogenome.org/gene/31033:LOC497080 ^@ http://purl.uniprot.org/uniprot/Q5GH52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/31033:atg13 ^@ http://purl.uniprot.org/uniprot/A0A674MZC9|||http://purl.uniprot.org/uniprot/H2SYP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG13 family. Metazoan subfamily.|||Preautophagosomal structure http://togogenome.org/gene/31033:LOC101065316 ^@ http://purl.uniprot.org/uniprot/H2U5R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:jund ^@ http://purl.uniprot.org/uniprot/Q800B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/31033:dcaf13 ^@ http://purl.uniprot.org/uniprot/H2T167 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DCAF13/WDSOF1 family.|||nucleolus http://togogenome.org/gene/31033:pepd ^@ http://purl.uniprot.org/uniprot/H2RRC7 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/31033:LOC101076124 ^@ http://purl.uniprot.org/uniprot/H2V277 ^@ Similarity ^@ Belongs to the CELF/BRUNOL family. http://togogenome.org/gene/31033:LOC101063823 ^@ http://purl.uniprot.org/uniprot/H2USZ6 ^@ Similarity ^@ Belongs to the PDE6D/unc-119 family. http://togogenome.org/gene/31033:LOC101070221 ^@ http://purl.uniprot.org/uniprot/H2SC76 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/31033:mtap ^@ http://purl.uniprot.org/uniprot/A0A674MAL1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Cytoplasm|||Homotrimer.|||Nucleus http://togogenome.org/gene/31033:sufu ^@ http://purl.uniprot.org/uniprot/H2TXY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SUFU family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:LOC101072793 ^@ http://purl.uniprot.org/uniprot/H2U140 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/31033:trappc4 ^@ http://purl.uniprot.org/uniprot/H2RM41 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/31033:prdm12 ^@ http://purl.uniprot.org/uniprot/H2VF00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Involved in the positive regulation of histone H3-K9 dimethylation.|||Nucleus http://togogenome.org/gene/31033:LOC101078521 ^@ http://purl.uniprot.org/uniprot/H2SRR0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC3 family.|||Component of the ER membrane protein complex (EMC).|||Membrane http://togogenome.org/gene/31033:gata4 ^@ http://purl.uniprot.org/uniprot/H2U141 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101072238 ^@ http://purl.uniprot.org/uniprot/A0A3B5KJ68|||http://purl.uniprot.org/uniprot/A0A3B5KQ21 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/31033:LOC101074771 ^@ http://purl.uniprot.org/uniprot/H2T6D5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM163 family.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/31033:hibch ^@ http://purl.uniprot.org/uniprot/H2U7H8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.|||Mitochondrion http://togogenome.org/gene/31033:LOC101070283 ^@ http://purl.uniprot.org/uniprot/H2TB62 ^@ Similarity ^@ Belongs to the glucagon family. http://togogenome.org/gene/31033:LOC101080194 ^@ http://purl.uniprot.org/uniprot/A0A3B5KMP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/31033:LOC101075770 ^@ http://purl.uniprot.org/uniprot/A0A6D2X4V5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/31033:LOC497075 ^@ http://purl.uniprot.org/uniprot/Q5GH48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/31033:LOC101074632 ^@ http://purl.uniprot.org/uniprot/H2VET9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/31033:lsm6 ^@ http://purl.uniprot.org/uniprot/A0A3B5KKE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/31033:atp5mf ^@ http://purl.uniprot.org/uniprot/H2S6Q4 ^@ Function|||Similarity ^@ Belongs to the ATPase F chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. http://togogenome.org/gene/31033:suclg2 ^@ http://purl.uniprot.org/uniprot/H2SRU0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.|||Binds 1 Mg(2+) ion per subunit.|||GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.|||Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.|||Mitochondrion http://togogenome.org/gene/31033:mc2r ^@ http://purl.uniprot.org/uniprot/Q7ZSX7 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/31033:mlec ^@ http://purl.uniprot.org/uniprot/A0A3B5KN14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the malectin family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:slc44a2 ^@ http://purl.uniprot.org/uniprot/A0A674MGG9|||http://purl.uniprot.org/uniprot/H2T9M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Membrane http://togogenome.org/gene/31033:icmt ^@ http://purl.uniprot.org/uniprot/H2T8D8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.|||Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:LOC101075600 ^@ http://purl.uniprot.org/uniprot/H2TAQ3 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/31033:cdk4 ^@ http://purl.uniprot.org/uniprot/A0A674NJC4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:LOC101075421 ^@ http://purl.uniprot.org/uniprot/H2RZ86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101074525 ^@ http://purl.uniprot.org/uniprot/A0A674PFG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/31033:srp54 ^@ http://purl.uniprot.org/uniprot/H2SY49 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).|||Cytoplasm|||Endoplasmic reticulum|||Nucleus speckle|||The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.|||The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER. http://togogenome.org/gene/31033:LOC105417819 ^@ http://purl.uniprot.org/uniprot/A0A674NI89|||http://purl.uniprot.org/uniprot/A0A674NZN3 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/31033:aurkaip1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K6D0 ^@ Similarity ^@ Belongs to the mitochondrion-specific ribosomal protein mS38 family. http://togogenome.org/gene/31033:LOC101063090 ^@ http://purl.uniprot.org/uniprot/A0A674N1B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:LOC101062484 ^@ http://purl.uniprot.org/uniprot/H2TLU1 ^@ Similarity ^@ Belongs to the SLAIN motif-containing family. http://togogenome.org/gene/31033:LOC101069895 ^@ http://purl.uniprot.org/uniprot/H2VEI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XRCC4 subfamily.|||Nucleus http://togogenome.org/gene/31033:septin6 ^@ http://purl.uniprot.org/uniprot/A0A674MNT4 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/31033:cblb ^@ http://purl.uniprot.org/uniprot/H2RM67 ^@ Domain|||Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.|||The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. http://togogenome.org/gene/31033:hadha ^@ http://purl.uniprot.org/uniprot/H2TST0 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/31033:LOC101067277 ^@ http://purl.uniprot.org/uniprot/H2RJL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. http://togogenome.org/gene/31033:hmox2 ^@ http://purl.uniprot.org/uniprot/H2SXN5 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/31033:slc48a1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KF02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HRG family.|||Endosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/31033:LOC101079283 ^@ http://purl.uniprot.org/uniprot/H2VDZ3 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/31033:smc4 ^@ http://purl.uniprot.org/uniprot/Q8AW94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family.|||Chromosome|||Nucleus http://togogenome.org/gene/31033:LOC101070245 ^@ http://purl.uniprot.org/uniprot/H2S0M9 ^@ Similarity ^@ Belongs to the RAPGEF2 family. http://togogenome.org/gene/31033:rbpms2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KJR4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:LOC101064331 ^@ http://purl.uniprot.org/uniprot/A0A674NJN2 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/31033:LOC101075480 ^@ http://purl.uniprot.org/uniprot/H2TPN5 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/31033:ebna1bp2 ^@ http://purl.uniprot.org/uniprot/H2VDM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP2 family.|||Required for the processing of the 27S pre-rRNA.|||nucleolus http://togogenome.org/gene/31033:trh ^@ http://purl.uniprot.org/uniprot/H2TW65 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRH family.|||Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.|||Secreted http://togogenome.org/gene/31033:gabarap ^@ http://purl.uniprot.org/uniprot/H2TXA4 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/31033:pah ^@ http://purl.uniprot.org/uniprot/A0A674NY98|||http://purl.uniprot.org/uniprot/Q6IVY7 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/31033:LOC101061939 ^@ http://purl.uniprot.org/uniprot/Q6IEH9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:med29 ^@ http://purl.uniprot.org/uniprot/A0A3B5KIZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 29 family.|||Nucleus http://togogenome.org/gene/31033:exoc5 ^@ http://purl.uniprot.org/uniprot/A0A3B5KIV1 ^@ Similarity ^@ Belongs to the SEC10 family. http://togogenome.org/gene/31033:pkm ^@ http://purl.uniprot.org/uniprot/Q8JJC2 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/31033:tm9sf2 ^@ http://purl.uniprot.org/uniprot/H2SS09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/31033:mthfs ^@ http://purl.uniprot.org/uniprot/A0A3B5KFU0 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/31033:ahsa1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KA38 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/31033:LOC101078539 ^@ http://purl.uniprot.org/uniprot/H2SAB8 ^@ Cofactor|||Similarity ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/31033:cacul1 ^@ http://purl.uniprot.org/uniprot/H2VA15 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/31033:LOC101061420 ^@ http://purl.uniprot.org/uniprot/A0A674NBR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tumor necrosis factor family.|||Membrane|||Secreted http://togogenome.org/gene/31033:tmem50a ^@ http://purl.uniprot.org/uniprot/H2RUS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/31033:LOC101062079 ^@ http://purl.uniprot.org/uniprot/H2T5B9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/31033:LOC101067051 ^@ http://purl.uniprot.org/uniprot/A0A173MRX2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit beta family.|||Heterodimer of an alpha and a beta chain.|||Involved in gametogenesis and steroidogenesis.|||Secreted http://togogenome.org/gene/31033:clpp ^@ http://purl.uniprot.org/uniprot/H2U4U1 ^@ Similarity ^@ Belongs to the peptidase S14 family. http://togogenome.org/gene/31033:cct4 ^@ http://purl.uniprot.org/uniprot/P53451 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.|||Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.|||Cytoplasm http://togogenome.org/gene/31033:LOC101077379 ^@ http://purl.uniprot.org/uniprot/H2RUL2 ^@ Similarity ^@ Belongs to the ubiquitin family. http://togogenome.org/gene/31033:stk39 ^@ http://purl.uniprot.org/uniprot/A0A674P684 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/31033:dkk2 ^@ http://purl.uniprot.org/uniprot/A0A3B5K2Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/31033:LOC101076610 ^@ http://purl.uniprot.org/uniprot/H2UBN8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/31033:LOC101075591 ^@ http://purl.uniprot.org/uniprot/H2UD84 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. http://togogenome.org/gene/31033:mbtd1 ^@ http://purl.uniprot.org/uniprot/H2SQS6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101078733 ^@ http://purl.uniprot.org/uniprot/H2RQ54 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/31033:ccnj ^@ http://purl.uniprot.org/uniprot/H2TUP2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. http://togogenome.org/gene/31033:LOC101061903 ^@ http://purl.uniprot.org/uniprot/H2TM50 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:ddx1 ^@ http://purl.uniprot.org/uniprot/H2UTK8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DDX1 subfamily.|||Cytoplasmic granule|||RNA helicase.|||The helicase domain is involved in the stimulation of RELA transcriptional activity. http://togogenome.org/gene/31033:lnpk ^@ http://purl.uniprot.org/uniprot/H2V6X4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lunapark family.|||Endoplasmic reticulum membrane|||Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.|||Plays a role in determining ER morphology.|||The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation. http://togogenome.org/gene/31033:slc5a8 ^@ http://purl.uniprot.org/uniprot/H2SHT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/31033:LOC101067374 ^@ http://purl.uniprot.org/uniprot/H2TDA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM229 family.|||Membrane http://togogenome.org/gene/31033:cdk2ap2 ^@ http://purl.uniprot.org/uniprot/A0A674NH37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDK2AP family.|||Nucleus http://togogenome.org/gene/31033:cdk9 ^@ http://purl.uniprot.org/uniprot/H2TD26 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:b4galt7 ^@ http://purl.uniprot.org/uniprot/Q2HPN2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/31033:igflr1 ^@ http://purl.uniprot.org/uniprot/A0A674N640 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:mrgbp ^@ http://purl.uniprot.org/uniprot/H2SRW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EAF7 family.|||Nucleus http://togogenome.org/gene/31033:vps11 ^@ http://purl.uniprot.org/uniprot/H2S5N0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS11 family.|||Cytoplasmic vesicle|||Early endosome|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.|||autophagosome|||clathrin-coated vesicle http://togogenome.org/gene/31033:LOC101076444 ^@ http://purl.uniprot.org/uniprot/H2UHG6 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/31033:npm3 ^@ http://purl.uniprot.org/uniprot/H2TXR6 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/31033:LOC101075808 ^@ http://purl.uniprot.org/uniprot/H2TRE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/31033:LOC101070549 ^@ http://purl.uniprot.org/uniprot/H2SE13 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family. http://togogenome.org/gene/31033:LOC101064982 ^@ http://purl.uniprot.org/uniprot/H2TII2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POMC family.|||Endogenous opiate.|||Secreted|||Stimulates the adrenal glands to release cortisol. http://togogenome.org/gene/31033:vsx2 ^@ http://purl.uniprot.org/uniprot/A0A674NG98 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:ptcd2 ^@ http://purl.uniprot.org/uniprot/H2VD74 ^@ Similarity ^@ Belongs to the PTCD2 family. http://togogenome.org/gene/31033:prkn ^@ http://purl.uniprot.org/uniprot/Q5J4W3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBR family. Parkin subfamily.|||Forms an E3 ubiquitin ligase complex.|||Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.|||Mitochondrion|||cytosol http://togogenome.org/gene/31033:LOC101063809 ^@ http://purl.uniprot.org/uniprot/H2UUA8 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/31033:LOC101067616 ^@ http://purl.uniprot.org/uniprot/A0A674PDW8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/31033:selenoi ^@ http://purl.uniprot.org/uniprot/A0A3B5KE84 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/31033:tacr3b ^@ http://purl.uniprot.org/uniprot/A0A6D2WUF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:psmc1 ^@ http://purl.uniprot.org/uniprot/H2S9Y9 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/31033:LOC101068458 ^@ http://purl.uniprot.org/uniprot/H2UJ44 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular space http://togogenome.org/gene/31033:LOC101072182 ^@ http://purl.uniprot.org/uniprot/A0A3B5JW50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the securin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:LOC101064194 ^@ http://purl.uniprot.org/uniprot/H2TFZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/31033:pla2g12a ^@ http://purl.uniprot.org/uniprot/A0A3B5KPP2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/31033:clstn3 ^@ http://purl.uniprot.org/uniprot/A0A674NJM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calsyntenin family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Postsynaptic cell membrane http://togogenome.org/gene/31033:LOC101065066 ^@ http://purl.uniprot.org/uniprot/A0A3B5JVR8|||http://purl.uniprot.org/uniprot/A0A3B5KI60 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/31033:LOC105416477 ^@ http://purl.uniprot.org/uniprot/A0A3B5KA49 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Nematocyst|||Target cell membrane http://togogenome.org/gene/31033:tmem170a ^@ http://purl.uniprot.org/uniprot/A0A3B5K6M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/31033:smoc2 ^@ http://purl.uniprot.org/uniprot/H2V823 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101073900 ^@ http://purl.uniprot.org/uniprot/H2UKM6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101064759 ^@ http://purl.uniprot.org/uniprot/H2U885|||http://purl.uniprot.org/uniprot/H2U886 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/31033:LOC101079269 ^@ http://purl.uniprot.org/uniprot/Q2PR24 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:slc25a16 ^@ http://purl.uniprot.org/uniprot/H2UD72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:LOC101073701 ^@ http://purl.uniprot.org/uniprot/A0A674MKL7 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/31033:mgrn1 ^@ http://purl.uniprot.org/uniprot/H2TY57 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin ligase. http://togogenome.org/gene/31033:drd4 ^@ http://purl.uniprot.org/uniprot/H2UQY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:gtf2a1 ^@ http://purl.uniprot.org/uniprot/H2VA00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 1 family.|||Nucleus http://togogenome.org/gene/31033:LOC101071831 ^@ http://purl.uniprot.org/uniprot/A0A3B5KGV7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:cdkal1 ^@ http://purl.uniprot.org/uniprot/H2T817 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.|||Endoplasmic reticulum membrane http://togogenome.org/gene/31033:dusp7 ^@ http://purl.uniprot.org/uniprot/A0A674NIM1 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/31033:scn3b ^@ http://purl.uniprot.org/uniprot/A0A674MGK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.|||Membrane|||Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. http://togogenome.org/gene/31033:snrpd1 ^@ http://purl.uniprot.org/uniprot/H2TD27 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. http://togogenome.org/gene/31033:crabp1 ^@ http://purl.uniprot.org/uniprot/A0A674NA52 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/31033:LOC101077450 ^@ http://purl.uniprot.org/uniprot/H2RMS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIP3 family.|||Membrane http://togogenome.org/gene/31033:LOC101063545 ^@ http://purl.uniprot.org/uniprot/H2SNB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/31033:glyr1 ^@ http://purl.uniprot.org/uniprot/A0A674M980|||http://purl.uniprot.org/uniprot/A0A674PLI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HIBADH-related family. NP60 subfamily.|||Chromosome http://togogenome.org/gene/31033:LOC101071295 ^@ http://purl.uniprot.org/uniprot/H2UJ73 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/31033:LOC101068558 ^@ http://purl.uniprot.org/uniprot/A0A3B5K4R9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:LOC101073915 ^@ http://purl.uniprot.org/uniprot/H2UYY3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/31033:rln ^@ http://purl.uniprot.org/uniprot/Q0GY47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/31033:ttc36 ^@ http://purl.uniprot.org/uniprot/A0A3B5KWH6 ^@ Similarity ^@ Belongs to the TTC36 family. http://togogenome.org/gene/31033:LOC101078401 ^@ http://purl.uniprot.org/uniprot/H2TQY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:id2 ^@ http://purl.uniprot.org/uniprot/H2UJT8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:gba2 ^@ http://purl.uniprot.org/uniprot/H2VAT6 ^@ Function|||Similarity ^@ Belongs to the non-lysosomal glucosylceramidase family.|||Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. http://togogenome.org/gene/31033:smim19 ^@ http://purl.uniprot.org/uniprot/H2RQL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM19 family.|||Membrane http://togogenome.org/gene/31033:LOC101077059 ^@ http://purl.uniprot.org/uniprot/Q800B5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/31033:LOC101061875 ^@ http://purl.uniprot.org/uniprot/H2UVC4 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rieske iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Membrane|||Mitochondrion inner membrane|||The Rieske protein is a high potential 2Fe-2S protein. http://togogenome.org/gene/31033:LOC101072553 ^@ http://purl.uniprot.org/uniprot/H2V0H6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101067200 ^@ http://purl.uniprot.org/uniprot/A0A674NJ85 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/31033:trmt11 ^@ http://purl.uniprot.org/uniprot/Q7T065 ^@ Function ^@ Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs. http://togogenome.org/gene/31033:cldn3d ^@ http://purl.uniprot.org/uniprot/Q6E5R9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:tubgcp3 ^@ http://purl.uniprot.org/uniprot/H2V5A2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/31033:rpl34 ^@ http://purl.uniprot.org/uniprot/A0A674MSG0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/31033:cdc25b ^@ http://purl.uniprot.org/uniprot/H2V785 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/31033:LOC101064904 ^@ http://purl.uniprot.org/uniprot/H2TRX2 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:gle1 ^@ http://purl.uniprot.org/uniprot/H2SVR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GLE1 family.|||Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/31033:nadk ^@ http://purl.uniprot.org/uniprot/H2RNY1 ^@ Similarity ^@ Belongs to the NAD kinase family. http://togogenome.org/gene/31033:LOC101069728 ^@ http://purl.uniprot.org/uniprot/H2RQZ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:tecr ^@ http://purl.uniprot.org/uniprot/A0A3B5KAT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:efna1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K8B1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:popdc2 ^@ http://purl.uniprot.org/uniprot/H2UUV4|||http://purl.uniprot.org/uniprot/H2UUV6 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/31033:LOC101068925 ^@ http://purl.uniprot.org/uniprot/A0A674MYD4|||http://purl.uniprot.org/uniprot/H2ULZ5|||http://purl.uniprot.org/uniprot/H2ULZ8 ^@ Function|||Similarity ^@ Belongs to the troponin T family.|||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/31033:tmco4 ^@ http://purl.uniprot.org/uniprot/A0A674MK81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMCO4 family.|||Membrane http://togogenome.org/gene/31033:phka1 ^@ http://purl.uniprot.org/uniprot/H2SYZ9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. http://togogenome.org/gene/31033:myc ^@ http://purl.uniprot.org/uniprot/H2TBQ9|||http://purl.uniprot.org/uniprot/Q3LFR6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.|||Nucleus|||Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. http://togogenome.org/gene/31033:foxa1 ^@ http://purl.uniprot.org/uniprot/H2SR73 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:tmem50b ^@ http://purl.uniprot.org/uniprot/H2RSU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/31033:kpna4 ^@ http://purl.uniprot.org/uniprot/H2SUD5 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/31033:LOC101066857 ^@ http://purl.uniprot.org/uniprot/H2UK03 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:cd8a ^@ http://purl.uniprot.org/uniprot/Q2HWR4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:amt ^@ http://purl.uniprot.org/uniprot/H2TCG8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvT family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/31033:sike1 ^@ http://purl.uniprot.org/uniprot/A0A674M9R9 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/31033:LOC101072610 ^@ http://purl.uniprot.org/uniprot/H2SL72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/31033:LOC101073797 ^@ http://purl.uniprot.org/uniprot/H2U7H3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/31033:c6h9orf16 ^@ http://purl.uniprot.org/uniprot/O73881 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0184 (EST00098) family.|||Cell junction|||Essential for intermediate filament organization in intestinal cells, interacts with intermediate filament and regulates intestinal lumen morphology.|||cytoskeleton http://togogenome.org/gene/31033:LOC101074017 ^@ http://purl.uniprot.org/uniprot/H2UGI0 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/31033:LOC101072782 ^@ http://purl.uniprot.org/uniprot/A0A674NU84 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/31033:LOC101074539 ^@ http://purl.uniprot.org/uniprot/A0A674NYF3 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/31033:tph1 ^@ http://purl.uniprot.org/uniprot/Q6IWN2 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/31033:LOC777946 ^@ http://purl.uniprot.org/uniprot/A0A3B5KC23|||http://purl.uniprot.org/uniprot/Q5XQ39 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/31033:dcp1a ^@ http://purl.uniprot.org/uniprot/H2S6N6 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/31033:LOC101078211 ^@ http://purl.uniprot.org/uniprot/A0A3B5KRU7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:LOC101076680 ^@ http://purl.uniprot.org/uniprot/A0A674MV74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/31033:LOC101077315 ^@ http://purl.uniprot.org/uniprot/H2U0L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||Nucleus http://togogenome.org/gene/31033:LOC105416747 ^@ http://purl.uniprot.org/uniprot/H2SPC2 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/31033:e2f1 ^@ http://purl.uniprot.org/uniprot/H2TU84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/31033:nsg1 ^@ http://purl.uniprot.org/uniprot/H2UVG2 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/31033:elavl3 ^@ http://purl.uniprot.org/uniprot/A0A674N7T6 ^@ Similarity ^@ Belongs to the RRM elav family. http://togogenome.org/gene/31033:LOC101062479 ^@ http://purl.uniprot.org/uniprot/A0A3B5KAS1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:mok ^@ http://purl.uniprot.org/uniprot/A0A674PA87 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:LOC101067841 ^@ http://purl.uniprot.org/uniprot/H2T1C7 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/31033:ncbp2 ^@ http://purl.uniprot.org/uniprot/A0A674N766 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRM NCBP2 family.|||Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.|||Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.|||Nucleus http://togogenome.org/gene/31033:cnot10 ^@ http://purl.uniprot.org/uniprot/H2SR13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT10 family.|||Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:lsm12 ^@ http://purl.uniprot.org/uniprot/H2SYL5 ^@ Similarity ^@ Belongs to the LSM12 family. http://togogenome.org/gene/31033:polr2h ^@ http://purl.uniprot.org/uniprot/H2T2K8 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RPB8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/31033:LOC101068591 ^@ http://purl.uniprot.org/uniprot/A0A3B5KR16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX15/CtaA family.|||Membrane http://togogenome.org/gene/31033:rab18 ^@ http://purl.uniprot.org/uniprot/A0A674N6R6 ^@ Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Lipid droplet http://togogenome.org/gene/31033:fignl1 ^@ http://purl.uniprot.org/uniprot/H2V8M7 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/31033:casp3 ^@ http://purl.uniprot.org/uniprot/Q8JGM9 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/31033:naa38 ^@ http://purl.uniprot.org/uniprot/A0A674NUM5 ^@ Function|||Similarity|||Subunit ^@ Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.|||Belongs to the snRNP Sm proteins family.|||Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30. http://togogenome.org/gene/31033:LOC101079431 ^@ http://purl.uniprot.org/uniprot/H2TSX0 ^@ Similarity ^@ Belongs to the WD repeat ARPC1 family. http://togogenome.org/gene/31033:msrb2 ^@ http://purl.uniprot.org/uniprot/H2RVH9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit.|||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. http://togogenome.org/gene/31033:LOC101079903 ^@ http://purl.uniprot.org/uniprot/A0A3B5KQ57 ^@ Similarity|||Subunit ^@ Belongs to the 14-3-3 family.|||Homodimer, and heterodimer with other family members. http://togogenome.org/gene/31033:ncdn ^@ http://purl.uniprot.org/uniprot/H2TDL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the neurochondrin family.|||Postsynapse http://togogenome.org/gene/31033:ranbp10 ^@ http://purl.uniprot.org/uniprot/A0A3B5KD73 ^@ Similarity ^@ Belongs to the RANBP9/10 family. http://togogenome.org/gene/31033:tpm1 ^@ http://purl.uniprot.org/uniprot/Q805D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/31033:st14 ^@ http://purl.uniprot.org/uniprot/H2TQ40 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:rpf1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K696 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/31033:hopx ^@ http://purl.uniprot.org/uniprot/A0A3B5K7Y3 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:mcrip1 ^@ http://purl.uniprot.org/uniprot/A0A674NV26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCRIP family.|||Nucleus|||Stress granule http://togogenome.org/gene/31033:LOC101066695 ^@ http://purl.uniprot.org/uniprot/A0A674PKG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/31033:camk1g ^@ http://purl.uniprot.org/uniprot/A0A3B5KIY8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:nans ^@ http://purl.uniprot.org/uniprot/H2US31 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type-III AFP family.|||Contributes to protect fish blood from freezing at subzero sea water temperatures. Lowers the blood freezing point. Binds to nascent ice crystals and prevents further growth.|||Secreted http://togogenome.org/gene/31033:LOC101075515 ^@ http://purl.uniprot.org/uniprot/A0A674NB52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/31033:lhx4 ^@ http://purl.uniprot.org/uniprot/H2TLV5 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101065380 ^@ http://purl.uniprot.org/uniprot/Q6E5T5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:b3gnt7 ^@ http://purl.uniprot.org/uniprot/A0A3B5KKS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:LOC101076758 ^@ http://purl.uniprot.org/uniprot/H2T767 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family.|||Heterodimer; with an rxr molecule. Binds DNA preferentially as a rar/rxr heterodimer.|||Nucleus http://togogenome.org/gene/31033:best3 ^@ http://purl.uniprot.org/uniprot/A0A674NGH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms chloride channels.|||Membrane http://togogenome.org/gene/31033:LOC101075726 ^@ http://purl.uniprot.org/uniprot/A0A674MZ54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Membrane http://togogenome.org/gene/31033:mturn ^@ http://purl.uniprot.org/uniprot/H2UEE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MTURN family.|||Cytoplasm http://togogenome.org/gene/31033:plod1 ^@ http://purl.uniprot.org/uniprot/A5A6S1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/31033:LOC105416362 ^@ http://purl.uniprot.org/uniprot/A0A3B5KNK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Vesicular transporter family.|||Membrane http://togogenome.org/gene/31033:LOC101072603 ^@ http://purl.uniprot.org/uniprot/Q1KKW9 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101064572 ^@ http://purl.uniprot.org/uniprot/H2TN31 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:slc5a1 ^@ http://purl.uniprot.org/uniprot/A0A674PD87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/31033:c21h9orf78 ^@ http://purl.uniprot.org/uniprot/A0A674MUH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TLS1 family.|||Nucleus http://togogenome.org/gene/31033:LOC105417999 ^@ http://purl.uniprot.org/uniprot/H2UE10 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101072058 ^@ http://purl.uniprot.org/uniprot/H2RUY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:aimp2 ^@ http://purl.uniprot.org/uniprot/A0A674NTG6 ^@ Subcellular Location Annotation ^@ Nucleus|||cytosol http://togogenome.org/gene/31033:vangl1 ^@ http://purl.uniprot.org/uniprot/H2S8F4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:mthfd1 ^@ http://purl.uniprot.org/uniprot/H2U4F9 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.|||In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. http://togogenome.org/gene/31033:stx5 ^@ http://purl.uniprot.org/uniprot/H2U8A7 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/31033:utp6 ^@ http://purl.uniprot.org/uniprot/H2U0C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP6 family.|||nucleolus http://togogenome.org/gene/31033:fmnl2 ^@ http://purl.uniprot.org/uniprot/A0A674P8H8 ^@ Similarity ^@ Belongs to the formin homology family. http://togogenome.org/gene/31033:atp5mc1 ^@ http://purl.uniprot.org/uniprot/Q1KKY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/31033:LOC101061729 ^@ http://purl.uniprot.org/uniprot/A0A674NMZ8|||http://purl.uniprot.org/uniprot/H2SKD4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/31033:zar1 ^@ http://purl.uniprot.org/uniprot/A0A3B5JVH4|||http://purl.uniprot.org/uniprot/Q7T3T9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZAR1 family.|||Cytoplasmic ribonucleoprotein granule|||Disordered regions undergo liquid-liquid phase separation (LLPS) for the formation of membraneless compartments that store maternal mRNAs in oocytes.|||The 3CxxC-type mediates binding to the 3'-UTR of mRNAs.|||mRNA-binding protein required for maternal mRNA storage, translation and degradation during oocyte maturation (By similarity). Probably promotes formation of some phase-separated membraneless compartment that stores maternal mRNAs in oocytes: acts by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (By similarity). Binds to the 3'-UTR of maternal mRNAs, inhibiting their translation (By similarity). http://togogenome.org/gene/31033:LOC101073898 ^@ http://purl.uniprot.org/uniprot/A0A3B5K5K1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LEAP2 family.|||Has an antimicrobial activity.|||Secreted http://togogenome.org/gene/31033:lgi3 ^@ http://purl.uniprot.org/uniprot/Q1EGK0 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/31033:LOC101075938 ^@ http://purl.uniprot.org/uniprot/A0A674M9U3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:gal3st1 ^@ http://purl.uniprot.org/uniprot/H2UV08 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/31033:LOC101068869 ^@ http://purl.uniprot.org/uniprot/A0A674MI10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/31033:sntg1 ^@ http://purl.uniprot.org/uniprot/A0A674ML37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||cytoskeleton http://togogenome.org/gene/31033:pcmt1 ^@ http://purl.uniprot.org/uniprot/H2RSL9 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/31033:sptbn1 ^@ http://purl.uniprot.org/uniprot/H2U143 ^@ Similarity ^@ Belongs to the spectrin family. http://togogenome.org/gene/31033:LOC101074625 ^@ http://purl.uniprot.org/uniprot/A0A674MVD4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/31033:atp8a2 ^@ http://purl.uniprot.org/uniprot/H2RUN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/31033:dlst ^@ http://purl.uniprot.org/uniprot/H2VCN3 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/31033:bmp2 ^@ http://purl.uniprot.org/uniprot/Q804S3 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/31033:eif4ebp3 ^@ http://purl.uniprot.org/uniprot/H2RZT6 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/31033:pacap1b ^@ http://purl.uniprot.org/uniprot/Q5WML0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101064922 ^@ http://purl.uniprot.org/uniprot/H2V4X7 ^@ Similarity ^@ Belongs to the TMEM178 family. http://togogenome.org/gene/31033:LOC101075371 ^@ http://purl.uniprot.org/uniprot/A0A3B5KHV1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:rln3 ^@ http://purl.uniprot.org/uniprot/Q0GY50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/31033:braf ^@ http://purl.uniprot.org/uniprot/Q4W6L8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/31033:ro60 ^@ http://purl.uniprot.org/uniprot/H2THV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ro 60 kDa family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101074127 ^@ http://purl.uniprot.org/uniprot/Q6E5Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/31033:LOC101068024 ^@ http://purl.uniprot.org/uniprot/H2S8T6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/31033:vasn ^@ http://purl.uniprot.org/uniprot/H2SVU4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101065425 ^@ http://purl.uniprot.org/uniprot/A0A3B5K588 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/31033:prpf31 ^@ http://purl.uniprot.org/uniprot/A0A674PAL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP31 family.|||Cajal body http://togogenome.org/gene/31033:tmem47 ^@ http://purl.uniprot.org/uniprot/H2V7X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/31033:syncrip ^@ http://purl.uniprot.org/uniprot/H2SKE4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:LOC101069215 ^@ http://purl.uniprot.org/uniprot/I6L6Z9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:flot1 ^@ http://purl.uniprot.org/uniprot/A0A674NGH2|||http://purl.uniprot.org/uniprot/A1KZS6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Endosome|||Heterooligomeric complex.|||Membrane http://togogenome.org/gene/31033:tent5c ^@ http://purl.uniprot.org/uniprot/A0A674MS26 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/31033:smc5 ^@ http://purl.uniprot.org/uniprot/Q802R9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family. SMC5 subfamily.|||Chromosome|||Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6 (By similarity).|||Forms a heterodimer with smc6. Component of the SMC5-SMC6 complex which consists at least of smc5, smc6, nsmce2, nsmce1 and nsmce4a (By similarity).|||Nucleus|||The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC6, forming a V-shaped heterodimer.|||telomere http://togogenome.org/gene/31033:dynlt1 ^@ http://purl.uniprot.org/uniprot/A0A674N323 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/31033:dnajc22 ^@ http://purl.uniprot.org/uniprot/H2U0K7 ^@ Function|||Subcellular Location Annotation ^@ May function as a co-chaperone.|||Membrane http://togogenome.org/gene/31033:LOC101079120 ^@ http://purl.uniprot.org/uniprot/A0A3B5KRU7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:LOC101067723 ^@ http://purl.uniprot.org/uniprot/A0A3B5KRR9|||http://purl.uniprot.org/uniprot/A0A674NZ98 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Membrane|||Midbody|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. http://togogenome.org/gene/31033:bloc1s1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KDZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BLOC1S1 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/31033:ppme1 ^@ http://purl.uniprot.org/uniprot/H2UIT3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the AB hydrolase superfamily.|||Binds PPP2CA and PPP2CB.|||Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. http://togogenome.org/gene/31033:ndufb10 ^@ http://purl.uniprot.org/uniprot/A0A674MYJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.|||Belongs to the complex I NDUFB10 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:LOC101063780 ^@ http://purl.uniprot.org/uniprot/A0A674PHS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/31033:LOC101068305 ^@ http://purl.uniprot.org/uniprot/A0A674MEC3 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/31033:LOC101076253 ^@ http://purl.uniprot.org/uniprot/A0A3B5K339 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase inhibitor family.|||Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.|||Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.|||Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.|||Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.|||Mitochondrion http://togogenome.org/gene/31033:LOC101064278 ^@ http://purl.uniprot.org/uniprot/A0A674MVT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/31033:LOC101072780 ^@ http://purl.uniprot.org/uniprot/H2V2Q8 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/31033:LOC101078894 ^@ http://purl.uniprot.org/uniprot/A0A674MBZ2 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/31033:ggt1 ^@ http://purl.uniprot.org/uniprot/H2UXU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyltransferase family.|||Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.|||Membrane http://togogenome.org/gene/31033:ciao2a ^@ http://purl.uniprot.org/uniprot/A0A674MQG9 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/31033:gucy1b1 ^@ http://purl.uniprot.org/uniprot/Q90VY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101066812 ^@ http://purl.uniprot.org/uniprot/H2RND2 ^@ Similarity ^@ Belongs to the SLBP family. http://togogenome.org/gene/31033:ppm1d ^@ http://purl.uniprot.org/uniprot/H2T2P5 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/31033:LOC101062406 ^@ http://purl.uniprot.org/uniprot/H2SIJ5 ^@ Similarity ^@ Belongs to the glutaminyl-peptide cyclotransferase family. http://togogenome.org/gene/31033:slc6a1 ^@ http://purl.uniprot.org/uniprot/A0A674P5P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/31033:LOC101068078 ^@ http://purl.uniprot.org/uniprot/H2V4Y2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:ndufb11 ^@ http://purl.uniprot.org/uniprot/A0A674NM05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB11 subunit family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/31033:armc8 ^@ http://purl.uniprot.org/uniprot/H2UP57 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/31033:alg9 ^@ http://purl.uniprot.org/uniprot/H2V3V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:tmem267 ^@ http://purl.uniprot.org/uniprot/A0A3B5K3X5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC115246485 ^@ http://purl.uniprot.org/uniprot/A0A674MNM4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101076943 ^@ http://purl.uniprot.org/uniprot/A0A674NZ63 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/31033:ube2k ^@ http://purl.uniprot.org/uniprot/H2U247 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/31033:polr2e ^@ http://purl.uniprot.org/uniprot/H2VBT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.|||Nucleus http://togogenome.org/gene/31033:cript ^@ http://purl.uniprot.org/uniprot/H2SG76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRIPT family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101078242 ^@ http://purl.uniprot.org/uniprot/H2TH23 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/31033:cenpm ^@ http://purl.uniprot.org/uniprot/H2RIX7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:cfl1 ^@ http://purl.uniprot.org/uniprot/H2U377 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/31033:slc16a9 ^@ http://purl.uniprot.org/uniprot/H2TCH1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101063432 ^@ http://purl.uniprot.org/uniprot/H2RU44 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/31033:pax6 ^@ http://purl.uniprot.org/uniprot/A0A674NSN2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:sppl2a ^@ http://purl.uniprot.org/uniprot/H2SR20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Membrane http://togogenome.org/gene/31033:nup85 ^@ http://purl.uniprot.org/uniprot/H2TUD8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup85 family.|||Component of the nuclear pore complex (NPC).|||Functions as a component of the nuclear pore complex (NPC).|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/31033:cd3g/d ^@ http://purl.uniprot.org/uniprot/Q589Z0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101075152 ^@ http://purl.uniprot.org/uniprot/A0A3B5K420 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:alpl ^@ http://purl.uniprot.org/uniprot/Q8AXY3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alkaline phosphatase family.|||Binds 1 Mg(2+) ion.|||Binds 2 Zn(2+) ions.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/31033:lyz ^@ http://purl.uniprot.org/uniprot/P61944 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 22 family.|||Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.|||Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.|||Monomer.|||Secreted http://togogenome.org/gene/31033:LOC101072910 ^@ http://purl.uniprot.org/uniprot/A0A3B5K3I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:LOC101079077 ^@ http://purl.uniprot.org/uniprot/A0A674NDN3 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/31033:tamm41 ^@ http://purl.uniprot.org/uniprot/H2S0L1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAM41 family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:slc25a40 ^@ http://purl.uniprot.org/uniprot/H2SID0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:LOC100049642 ^@ http://purl.uniprot.org/uniprot/A1KZS8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Endosome|||Heterooligomeric complex.|||Membrane http://togogenome.org/gene/31033:LOC101069212 ^@ http://purl.uniprot.org/uniprot/A0A6D2X1D0 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/31033:LOC101079435 ^@ http://purl.uniprot.org/uniprot/A0A674N212|||http://purl.uniprot.org/uniprot/H2S3K0 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/31033:supt20h ^@ http://purl.uniprot.org/uniprot/H2RX91|||http://purl.uniprot.org/uniprot/H2RX92 ^@ Similarity ^@ Belongs to the SPT20 family. http://togogenome.org/gene/31033:jun ^@ http://purl.uniprot.org/uniprot/Q800B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/31033:adcy7 ^@ http://purl.uniprot.org/uniprot/H2SYJ6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/31033:pax9 ^@ http://purl.uniprot.org/uniprot/A0A674MJB2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101077658 ^@ http://purl.uniprot.org/uniprot/H2TH47 ^@ Similarity ^@ Belongs to the bZIP family. NFIL3 subfamily. http://togogenome.org/gene/31033:LOC101067398 ^@ http://purl.uniprot.org/uniprot/H2U4T1 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/31033:ccnl1 ^@ http://purl.uniprot.org/uniprot/H2U6Q3 ^@ Similarity|||Subunit ^@ Belongs to the cyclin family.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. http://togogenome.org/gene/31033:dck ^@ http://purl.uniprot.org/uniprot/A0A674PNN2 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/31033:pacap1a ^@ http://purl.uniprot.org/uniprot/Q5WML1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC105419466 ^@ http://purl.uniprot.org/uniprot/H2V7P7 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/31033:LOC101073251 ^@ http://purl.uniprot.org/uniprot/H2UPT9 ^@ Similarity ^@ Belongs to the YOS1 family. http://togogenome.org/gene/31033:ing4 ^@ http://purl.uniprot.org/uniprot/H2S021 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/31033:dio2 ^@ http://purl.uniprot.org/uniprot/B1B570 ^@ Function|||Similarity ^@ Belongs to the iodothyronine deiodinase family.|||Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine). http://togogenome.org/gene/31033:fcf1 ^@ http://purl.uniprot.org/uniprot/H2URA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP23/FCF1 family. FCF1 subfamily.|||nucleolus http://togogenome.org/gene/31033:higd1a ^@ http://purl.uniprot.org/uniprot/Q4W7H2 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/31033:LOC101066071 ^@ http://purl.uniprot.org/uniprot/H2S2A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:rad17 ^@ http://purl.uniprot.org/uniprot/A0A3B5KL10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad17/RAD24 family.|||Nucleus http://togogenome.org/gene/31033:vps18 ^@ http://purl.uniprot.org/uniprot/H2U883 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS18 family.|||Membrane http://togogenome.org/gene/31033:LOC101074654 ^@ http://purl.uniprot.org/uniprot/H2UB30 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/31033:LOC101078904 ^@ http://purl.uniprot.org/uniprot/A0A3B5K5W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/31033:orc2 ^@ http://purl.uniprot.org/uniprot/H2S924 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC2 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Component of the origin recognition complex (ORC).|||Nucleus http://togogenome.org/gene/31033:ercc1 ^@ http://purl.uniprot.org/uniprot/H2U935 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERCC1/RAD10/SWI10 family.|||Nucleus http://togogenome.org/gene/31033:LOC101065288 ^@ http://purl.uniprot.org/uniprot/A0A674MJM2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Golgi apparatus http://togogenome.org/gene/31033:LOC101065997 ^@ http://purl.uniprot.org/uniprot/A0A3B5K5Y3 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/31033:fmc1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K0I9 ^@ Similarity ^@ Belongs to the FMC1 family. http://togogenome.org/gene/31033:LOC101070352 ^@ http://purl.uniprot.org/uniprot/A0A3B5KB92 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:mcm5 ^@ http://purl.uniprot.org/uniprot/A0A3B5KD99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/31033:LOC101072652 ^@ http://purl.uniprot.org/uniprot/A0A3B5KDN7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:kif1bp ^@ http://purl.uniprot.org/uniprot/H2RTB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KIF-binding protein family.|||cytoskeleton http://togogenome.org/gene/31033:jpt2 ^@ http://purl.uniprot.org/uniprot/I7KJP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:LOC101072325 ^@ http://purl.uniprot.org/uniprot/H2SAZ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/31033:LOC101079999 ^@ http://purl.uniprot.org/uniprot/H2V0Q1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/31033:LOC101064581 ^@ http://purl.uniprot.org/uniprot/H2TVT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Recycling endosome|||phagosome|||trans-Golgi network membrane http://togogenome.org/gene/31033:LOC101068196 ^@ http://purl.uniprot.org/uniprot/A0A674PEU6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:nup58 ^@ http://purl.uniprot.org/uniprot/H2RTC0|||http://purl.uniprot.org/uniprot/H2RTC3 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/31033:utp23 ^@ http://purl.uniprot.org/uniprot/A0A674MSM1 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/31033:slc41a2 ^@ http://purl.uniprot.org/uniprot/A0A6D2WN87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/31033:LOC101064540 ^@ http://purl.uniprot.org/uniprot/H2RT39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/31033:LOC105416569 ^@ http://purl.uniprot.org/uniprot/H2V2S9 ^@ Similarity ^@ Belongs to the AP endonuclease 2 family. http://togogenome.org/gene/31033:slc35a3 ^@ http://purl.uniprot.org/uniprot/H2V8V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:LOC101063010 ^@ http://purl.uniprot.org/uniprot/H2T4N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/31033:LOC101074158 ^@ http://purl.uniprot.org/uniprot/A0A674NSP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYBC1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:LOC101065984 ^@ http://purl.uniprot.org/uniprot/H2TT21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/31033:ano7 ^@ http://purl.uniprot.org/uniprot/H2SG05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:stag1 ^@ http://purl.uniprot.org/uniprot/H2UCF5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/31033:med25 ^@ http://purl.uniprot.org/uniprot/H2SPY4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 25 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/31033:LOC101074476 ^@ http://purl.uniprot.org/uniprot/H2TWJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/31033:med28 ^@ http://purl.uniprot.org/uniprot/A0A3B5KCU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 28 family.|||Nucleus http://togogenome.org/gene/31033:snrnp27 ^@ http://purl.uniprot.org/uniprot/H2ULS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNUT3 family.|||May play a role in mRNA splicing.|||Nucleus|||Part of a tri-snRNP complex. http://togogenome.org/gene/31033:LOC101073539 ^@ http://purl.uniprot.org/uniprot/A0A674P0G4|||http://purl.uniprot.org/uniprot/H2TA96 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Homooctamer.|||UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. http://togogenome.org/gene/31033:svop ^@ http://purl.uniprot.org/uniprot/H2UJ37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/31033:psme1 ^@ http://purl.uniprot.org/uniprot/H2SK17 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/31033:LOC101062674 ^@ http://purl.uniprot.org/uniprot/H2UL13 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC115246478 ^@ http://purl.uniprot.org/uniprot/H2SUE7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Heterodimer of an alpha and a beta chain.|||Secreted http://togogenome.org/gene/31033:hoxa10 ^@ http://purl.uniprot.org/uniprot/Q1KKZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:rbp4 ^@ http://purl.uniprot.org/uniprot/H2TR59 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/31033:scoc ^@ http://purl.uniprot.org/uniprot/A0A674MMN8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SCOC family.|||Positive regulator of amino acid starvation-induced autophagy.|||trans-Golgi network http://togogenome.org/gene/31033:LOC101073142 ^@ http://purl.uniprot.org/uniprot/H2TEN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/31033:LOC101063668 ^@ http://purl.uniprot.org/uniprot/H2SVK2 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/31033:LOC101069347 ^@ http://purl.uniprot.org/uniprot/H2UPF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101078308 ^@ http://purl.uniprot.org/uniprot/A0A674NFM8|||http://purl.uniprot.org/uniprot/H2SZZ4 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/31033:tcea1 ^@ http://purl.uniprot.org/uniprot/H2TY90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/31033:LOC101075813 ^@ http://purl.uniprot.org/uniprot/A0A3B5KIU0 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/31033:lin28b ^@ http://purl.uniprot.org/uniprot/A0A674PJA9 ^@ Similarity ^@ Belongs to the lin-28 family. http://togogenome.org/gene/31033:alx1 ^@ http://purl.uniprot.org/uniprot/H2U5A6 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:scube1 ^@ http://purl.uniprot.org/uniprot/A0A674MIF4|||http://purl.uniprot.org/uniprot/A0A674MR27 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/31033:eif5 ^@ http://purl.uniprot.org/uniprot/H2SUY2 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/31033:prpf38b ^@ http://purl.uniprot.org/uniprot/H2TYE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||May be required for pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/31033:lhx9 ^@ http://purl.uniprot.org/uniprot/A0A674NWY6|||http://purl.uniprot.org/uniprot/A0A674P750 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:snrnp200 ^@ http://purl.uniprot.org/uniprot/H2RSA0 ^@ Similarity ^@ Belongs to the helicase family. SKI2 subfamily. http://togogenome.org/gene/31033:LOC101065873 ^@ http://purl.uniprot.org/uniprot/A0A3B5K8X7 ^@ Subcellular Location Annotation ^@ centriole|||cilium|||cis-Golgi network http://togogenome.org/gene/31033:pax1 ^@ http://purl.uniprot.org/uniprot/H2T659 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:rara ^@ http://purl.uniprot.org/uniprot/Q9W5Z3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Heterodimer; with an rxr molecule. Binds DNA preferentially as a rar/rxr heterodimer.|||Nucleus|||Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity).|||The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. http://togogenome.org/gene/31033:LOC101064814 ^@ http://purl.uniprot.org/uniprot/A0A674MS57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/31033:mtm1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KP70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/31033:slc25a53 ^@ http://purl.uniprot.org/uniprot/H2TM19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:LOC101077576 ^@ http://purl.uniprot.org/uniprot/A0A3B5KG71 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex.|||In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.|||Nucleus http://togogenome.org/gene/31033:pusl1 ^@ http://purl.uniprot.org/uniprot/H2TL91 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/31033:vps26c ^@ http://purl.uniprot.org/uniprot/H2SWQ0 ^@ Similarity ^@ Belongs to the VPS26 family. http://togogenome.org/gene/31033:LOC101061299 ^@ http://purl.uniprot.org/uniprot/A0A674P7W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/31033:LOC101075886 ^@ http://purl.uniprot.org/uniprot/H2RSD9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/31033:gprc5c ^@ http://purl.uniprot.org/uniprot/H2RZ63 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101064722 ^@ http://purl.uniprot.org/uniprot/A0A3B5KIX4 ^@ Similarity ^@ Belongs to the DOK family. Type A subfamily. http://togogenome.org/gene/31033:LOC101069612 ^@ http://purl.uniprot.org/uniprot/H2TFU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:paqr6 ^@ http://purl.uniprot.org/uniprot/H2U5Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/31033:c5h16orf72 ^@ http://purl.uniprot.org/uniprot/A0A3B5K4Z3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:p2rx1 ^@ http://purl.uniprot.org/uniprot/A0A674NL41 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/31033:LOC101072863 ^@ http://purl.uniprot.org/uniprot/H2TXB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-alpha family. G(12) subfamily.|||Membrane http://togogenome.org/gene/31033:tspan17 ^@ http://purl.uniprot.org/uniprot/A0A674MP29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/31033:LOC101062643 ^@ http://purl.uniprot.org/uniprot/A0A674P7G5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/31033:vip ^@ http://purl.uniprot.org/uniprot/A0A674NC38|||http://purl.uniprot.org/uniprot/A8DPE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/31033:rer1 ^@ http://purl.uniprot.org/uniprot/A0A674N3A2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RER1 family.|||Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.|||Membrane http://togogenome.org/gene/31033:sema6a ^@ http://purl.uniprot.org/uniprot/A0A674NUS9|||http://purl.uniprot.org/uniprot/A0A674PD85 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:pfcyp19a ^@ http://purl.uniprot.org/uniprot/A9EE90 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/31033:kcnd1 ^@ http://purl.uniprot.org/uniprot/H2UBT9 ^@ Subcellular Location Annotation ^@ Membrane|||dendrite http://togogenome.org/gene/31033:ppp1r21 ^@ http://purl.uniprot.org/uniprot/H2UDY7 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/31033:gpr146 ^@ http://purl.uniprot.org/uniprot/H2U2K3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:mvb12b ^@ http://purl.uniprot.org/uniprot/A0A674NCX7|||http://purl.uniprot.org/uniprot/H2U5D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MVB12 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/31033:fah ^@ http://purl.uniprot.org/uniprot/H2RNJ9 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/31033:insig1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KA23 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/31033:LOC101079882 ^@ http://purl.uniprot.org/uniprot/H2SCN5 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/31033:LOC101073398 ^@ http://purl.uniprot.org/uniprot/A0A3B5KF84 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/31033:zeb2 ^@ http://purl.uniprot.org/uniprot/H2SIJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:scf ^@ http://purl.uniprot.org/uniprot/C1PGH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCF family.|||Cytoplasm|||Secreted|||filopodium|||lamellipodium http://togogenome.org/gene/31033:mon1a ^@ http://purl.uniprot.org/uniprot/Q9YGN1 ^@ Similarity ^@ Belongs to the MON1/SAND family. http://togogenome.org/gene/31033:LOC101072315 ^@ http://purl.uniprot.org/uniprot/A0A3B5KHE0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family.|||Homodimer.|||Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). http://togogenome.org/gene/31033:cacnb2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KGS5|||http://purl.uniprot.org/uniprot/H2UYV1 ^@ Similarity ^@ Belongs to the calcium channel beta subunit family. http://togogenome.org/gene/31033:ccnb1 ^@ http://purl.uniprot.org/uniprot/H2TUR4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. http://togogenome.org/gene/31033:mbnl3 ^@ http://purl.uniprot.org/uniprot/Q56V19 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the muscleblind family.|||Cytoplasm|||Expressed in fast and slow myotomal muscle, heart, liver, skin, brain and testis.|||Involved in pre-mRNA alternative splicing regulation. Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction (By similarity).|||Nucleus http://togogenome.org/gene/31033:KEF89_p13 ^@ http://purl.uniprot.org/uniprot/Q8HCW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 1 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/31033:LOC101063597 ^@ http://purl.uniprot.org/uniprot/H2UHH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/31033:LOC101073389 ^@ http://purl.uniprot.org/uniprot/A0A674MC40 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:LOC101066922 ^@ http://purl.uniprot.org/uniprot/Q802A4 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/31033:LOC101073279 ^@ http://purl.uniprot.org/uniprot/H2S8V8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101080050 ^@ http://purl.uniprot.org/uniprot/H2U9C5 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. http://togogenome.org/gene/31033:bola2b ^@ http://purl.uniprot.org/uniprot/A0A674MT95 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/31033:smc6 ^@ http://purl.uniprot.org/uniprot/Q802R8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family. SMC6 subfamily.|||Chromosome|||Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity).|||Forms a heterodimer with smc5. Component of the SMC5-SMC6 complex which consists at least of smc5, smc6, nsmce2, nsmce1 and nsmce4a (By similarity).|||Nucleus|||The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC5, forming a V-shaped heterodimer.|||telomere http://togogenome.org/gene/31033:etv6 ^@ http://purl.uniprot.org/uniprot/H2T1G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/31033:oaz1b ^@ http://purl.uniprot.org/uniprot/H2UKG0 ^@ Similarity ^@ Belongs to the ODC antizyme family. http://togogenome.org/gene/31033:mtfr1l ^@ http://purl.uniprot.org/uniprot/H2T599 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/31033:LOC101072197 ^@ http://purl.uniprot.org/uniprot/H2UMM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Membrane http://togogenome.org/gene/31033:LOC101061764 ^@ http://purl.uniprot.org/uniprot/A0A674N9Y0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COA3 family.|||Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.|||Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.|||Membrane|||Required for assembly of cytochrome c oxidase (complex IV). http://togogenome.org/gene/31033:amotl2 ^@ http://purl.uniprot.org/uniprot/H2SEB3 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/31033:il6st ^@ http://purl.uniprot.org/uniprot/H2TZE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/31033:LOC101068129 ^@ http://purl.uniprot.org/uniprot/Q6W953 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101071428 ^@ http://purl.uniprot.org/uniprot/A0A674MHR9 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/31033:LOC101066450 ^@ http://purl.uniprot.org/uniprot/A0A3B5KDL8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/31033:il-2 ^@ http://purl.uniprot.org/uniprot/Q59A92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/31033:ifitm5 ^@ http://purl.uniprot.org/uniprot/A0A674NIG8 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/31033:dusp26 ^@ http://purl.uniprot.org/uniprot/A0A674N6V5 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of AMPK and MAPK1/2 signaling pathways.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/31033:LOC101064701 ^@ http://purl.uniprot.org/uniprot/H2SI11 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/31033:ppil2 ^@ http://purl.uniprot.org/uniprot/H2UPH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.|||Nucleus http://togogenome.org/gene/31033:LOC101071570 ^@ http://purl.uniprot.org/uniprot/A0A674NG36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101063217 ^@ http://purl.uniprot.org/uniprot/H2U704 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:tbx22 ^@ http://purl.uniprot.org/uniprot/H2TRG0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/31033:cdo1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KQS7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the cysteine dioxygenase family.|||Binds 1 Fe cation per subunit.|||Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen. http://togogenome.org/gene/31033:nox1 ^@ http://purl.uniprot.org/uniprot/A7E3K6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:sar1b ^@ http://purl.uniprot.org/uniprot/A0A3B5KN34 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/31033:spcs1 ^@ http://purl.uniprot.org/uniprot/A0A674P6L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:mrpl51 ^@ http://purl.uniprot.org/uniprot/A0A3B5KGF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL51 family.|||Mitochondrion http://togogenome.org/gene/31033:slc9a3r1 ^@ http://purl.uniprot.org/uniprot/A0A674PAK1 ^@ Function|||Subcellular Location Annotation ^@ Endomembrane system|||Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. http://togogenome.org/gene/31033:dock8 ^@ http://purl.uniprot.org/uniprot/A0A674MD03 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/31033:qrsl1 ^@ http://purl.uniprot.org/uniprot/A0A674PHJ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/31033:LOC101075744 ^@ http://purl.uniprot.org/uniprot/H2SNG9 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/31033:tmem161b ^@ http://purl.uniprot.org/uniprot/A0A3B5JY53|||http://purl.uniprot.org/uniprot/A0A3B5KFM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM161 family.|||Membrane http://togogenome.org/gene/31033:LOC101065277 ^@ http://purl.uniprot.org/uniprot/H2UT58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:utp3 ^@ http://purl.uniprot.org/uniprot/H2UK14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAS10 family.|||nucleolus http://togogenome.org/gene/31033:dpyd ^@ http://purl.uniprot.org/uniprot/A0A674NX04 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the dihydropyrimidine dehydrogenase family.|||Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.|||Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. http://togogenome.org/gene/31033:LOC101062683 ^@ http://purl.uniprot.org/uniprot/A0A3B5KWD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCO1/2 family.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:LOC101072757 ^@ http://purl.uniprot.org/uniprot/A0A674PG23|||http://purl.uniprot.org/uniprot/H2U9V1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:rbm15 ^@ http://purl.uniprot.org/uniprot/H2S341 ^@ Similarity ^@ Belongs to the RRM Spen family. http://togogenome.org/gene/31033:LOC101073846 ^@ http://purl.uniprot.org/uniprot/A0A3B5KN95 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/31033:kxd1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K8G3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KXD1 family.|||Lysosome membrane http://togogenome.org/gene/31033:LOC101067375 ^@ http://purl.uniprot.org/uniprot/H2VCE0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:dpy19l1 ^@ http://purl.uniprot.org/uniprot/A0A674NIR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/31033:tub ^@ http://purl.uniprot.org/uniprot/H2V5Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUB family.|||Secreted http://togogenome.org/gene/31033:LOC101070524 ^@ http://purl.uniprot.org/uniprot/H2RXJ8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:en2 ^@ http://purl.uniprot.org/uniprot/H2V9E9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Engrailed homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:rdh13 ^@ http://purl.uniprot.org/uniprot/H2UNZ8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/31033:LOC101068977 ^@ http://purl.uniprot.org/uniprot/H2RN76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101068244 ^@ http://purl.uniprot.org/uniprot/A0A674NPF3|||http://purl.uniprot.org/uniprot/A0A674P401 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/31033:hoxd12 ^@ http://purl.uniprot.org/uniprot/H2V6V6 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:cebpd ^@ http://purl.uniprot.org/uniprot/A0A3B5KNG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/31033:msl3 ^@ http://purl.uniprot.org/uniprot/H2U4T6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:naa40 ^@ http://purl.uniprot.org/uniprot/A0A674PGM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA40 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:LOC101073971 ^@ http://purl.uniprot.org/uniprot/H2RL21 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/31033:psmb2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KPC3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:wdr4 ^@ http://purl.uniprot.org/uniprot/H2RYB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat TRM82 family.|||Nucleus|||Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. http://togogenome.org/gene/31033:pigs ^@ http://purl.uniprot.org/uniprot/H2V3B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGS family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:LOC101075237 ^@ http://purl.uniprot.org/uniprot/H2RJS8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101070533 ^@ http://purl.uniprot.org/uniprot/Q2PR38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:tmem14a ^@ http://purl.uniprot.org/uniprot/A0A674PCQ2 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/31033:ebag9 ^@ http://purl.uniprot.org/uniprot/H2S9V9 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. http://togogenome.org/gene/31033:siat5-r ^@ http://purl.uniprot.org/uniprot/Q50J60|||http://purl.uniprot.org/uniprot/Q6KB57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/31033:arhgdia ^@ http://purl.uniprot.org/uniprot/H2T9Q1 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/31033:hoxd11 ^@ http://purl.uniprot.org/uniprot/I6L704 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101068762 ^@ http://purl.uniprot.org/uniprot/A0A674MNW3 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/31033:LOC101069117 ^@ http://purl.uniprot.org/uniprot/H2SR71 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-1 subfamily. http://togogenome.org/gene/31033:zmpste24 ^@ http://purl.uniprot.org/uniprot/H2T8A5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48A family.|||Binds 1 zinc ion per subunit.|||Endoplasmic reticulum membrane|||Proteolytically removes the C-terminal three residues of farnesylated proteins. http://togogenome.org/gene/31033:LOC446071 ^@ http://purl.uniprot.org/uniprot/O46705 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/31033:ghsr ^@ http://purl.uniprot.org/uniprot/H2U752 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101078795 ^@ http://purl.uniprot.org/uniprot/H2UCX0 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/31033:nop58 ^@ http://purl.uniprot.org/uniprot/A0A674P7F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus http://togogenome.org/gene/31033:bet1l ^@ http://purl.uniprot.org/uniprot/A0A674PLV0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101062980 ^@ http://purl.uniprot.org/uniprot/A0A6D2WAW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/31033:thoc2 ^@ http://purl.uniprot.org/uniprot/H2UNV2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THOC2 family.|||Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.|||Nucleus http://togogenome.org/gene/31033:LOC101069140 ^@ http://purl.uniprot.org/uniprot/H2UTU2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aggrecan/versican proteoglycan family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/31033:leprot ^@ http://purl.uniprot.org/uniprot/B3Y064 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the OB-RGRP/VPS55 family.|||Endosome membrane|||Golgi apparatus membrane|||Involved in protein trafficking. May be involved in the down-regulation of membrane protein levels (By similarity).|||Widely expressed. http://togogenome.org/gene/31033:nkiras1 ^@ http://purl.uniprot.org/uniprot/H2TCT2 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/31033:LOC101077344 ^@ http://purl.uniprot.org/uniprot/A0A674NLQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101064034 ^@ http://purl.uniprot.org/uniprot/H2UUQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/31033:grk7 ^@ http://purl.uniprot.org/uniprot/H2RNG0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/31033:ttc39b ^@ http://purl.uniprot.org/uniprot/H2TG08 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/31033:LOC101066257 ^@ http://purl.uniprot.org/uniprot/H2UVE4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:LOC101061116 ^@ http://purl.uniprot.org/uniprot/H2T3B2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101061927 ^@ http://purl.uniprot.org/uniprot/H2TVL8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101078354 ^@ http://purl.uniprot.org/uniprot/A0A674M998 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/31033:cog4 ^@ http://purl.uniprot.org/uniprot/H2VA36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG4 family.|||Golgi apparatus membrane http://togogenome.org/gene/31033:mif ^@ http://purl.uniprot.org/uniprot/Q5I4D1 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/31033:nsun2 ^@ http://purl.uniprot.org/uniprot/H2TYJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||extracellular exosome http://togogenome.org/gene/31033:hal ^@ http://purl.uniprot.org/uniprot/H2V2G0 ^@ Similarity ^@ Belongs to the PAL/histidase family. http://togogenome.org/gene/31033:LOC101067620 ^@ http://purl.uniprot.org/uniprot/A0A674PC09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 51 kDa subunit family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:LOC101063537 ^@ http://purl.uniprot.org/uniprot/H2TQ33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TM6SF family.|||Membrane http://togogenome.org/gene/31033:baz1b ^@ http://purl.uniprot.org/uniprot/H2SP38 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:kars ^@ http://purl.uniprot.org/uniprot/H2V6Z7 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/31033:LOC101067106 ^@ http://purl.uniprot.org/uniprot/A0A674NA58 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:fgfr2 ^@ http://purl.uniprot.org/uniprot/H2V7F6|||http://purl.uniprot.org/uniprot/H2V7F7|||http://purl.uniprot.org/uniprot/H2V7F8|||http://purl.uniprot.org/uniprot/H2V7F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC778011 ^@ http://purl.uniprot.org/uniprot/Q9IAH8 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Contains one covalently linked retinal chromophore.|||Membrane|||photoreceptor outer segment http://togogenome.org/gene/31033:impad1 ^@ http://purl.uniprot.org/uniprot/H2T0G9 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/31033:LOC101071543 ^@ http://purl.uniprot.org/uniprot/H2S9P1 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/31033:psma1 ^@ http://purl.uniprot.org/uniprot/H2TCF6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/31033:scamp4 ^@ http://purl.uniprot.org/uniprot/H2VC83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/31033:vps29 ^@ http://purl.uniprot.org/uniprot/H2SU42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.|||Belongs to the VPS29 family.|||Endosome membrane http://togogenome.org/gene/31033:st8sia1 ^@ http://purl.uniprot.org/uniprot/Q6KC14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/31033:nppc ^@ http://purl.uniprot.org/uniprot/Q805D3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Exhibits natriuretic and vasodepressant activity. Has cGMP-stimulating activity. May help to regulate body fluid homeostasis in a variety of aquatic environments.|||Secreted http://togogenome.org/gene/31033:LOC105416774 ^@ http://purl.uniprot.org/uniprot/H2TUI7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/31033:egr2 ^@ http://purl.uniprot.org/uniprot/H2RN54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/31033:eif5a ^@ http://purl.uniprot.org/uniprot/H2TY85 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||Membrane|||Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group. http://togogenome.org/gene/31033:LOC101074318 ^@ http://purl.uniprot.org/uniprot/P53483 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.|||Belongs to the actin family.|||Oxidation of Met-45 and Met-48 by MICALs (mical1, mical2 or mical3) to form methionine sulfoxide promotes actin filament depolymerization. Mical1 and mical2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by msrb1 and msrb2, which promote actin repolymerization (By similarity).|||Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.|||Predominantly expressed in testis.|||cytoskeleton http://togogenome.org/gene/31033:med21 ^@ http://purl.uniprot.org/uniprot/A0A674NFL1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 21 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/31033:nip7 ^@ http://purl.uniprot.org/uniprot/H2RK92 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NIP7 family.|||Interacts with pre-ribosome complex.|||Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.|||nucleolus http://togogenome.org/gene/31033:LOC101070900 ^@ http://purl.uniprot.org/uniprot/A0A674P7I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:LOC101077122 ^@ http://purl.uniprot.org/uniprot/A0A3B5KJ31 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:ada2 ^@ http://purl.uniprot.org/uniprot/H2RVT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.|||Secreted http://togogenome.org/gene/31033:LOC101071385 ^@ http://purl.uniprot.org/uniprot/A0A3B5JUL2|||http://purl.uniprot.org/uniprot/A0A3B5KHY3 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/31033:cacnb4.1 ^@ http://purl.uniprot.org/uniprot/A0A674PE22|||http://purl.uniprot.org/uniprot/B6IDE9 ^@ Similarity ^@ Belongs to the calcium channel beta subunit family. http://togogenome.org/gene/31033:ptar1 ^@ http://purl.uniprot.org/uniprot/A0A674NHW1 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family. http://togogenome.org/gene/31033:rplp0 ^@ http://purl.uniprot.org/uniprot/H2UUC0 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL10 family.|||Ribosomal protein P0 is the functional equivalent of E.coli protein L10. http://togogenome.org/gene/31033:dmrt1 ^@ http://purl.uniprot.org/uniprot/H2UT51|||http://purl.uniprot.org/uniprot/Q4AE32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/31033:LOC101073562 ^@ http://purl.uniprot.org/uniprot/H2RVM6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. http://togogenome.org/gene/31033:tlx1 ^@ http://purl.uniprot.org/uniprot/H2RLJ9 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:kif11 ^@ http://purl.uniprot.org/uniprot/H2U1Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.|||spindle pole http://togogenome.org/gene/31033:LOC101078280 ^@ http://purl.uniprot.org/uniprot/H2SZZ3 ^@ Similarity ^@ Belongs to the RRM elav family. http://togogenome.org/gene/31033:gp91phox ^@ http://purl.uniprot.org/uniprot/Q7T1Q1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:dph1 ^@ http://purl.uniprot.org/uniprot/A0A674MI41 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the DPH1/DPH2 family. DPH1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. http://togogenome.org/gene/31033:rpe65 ^@ http://purl.uniprot.org/uniprot/A0A674N730 ^@ Cofactor|||Similarity ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/31033:LOC101070422 ^@ http://purl.uniprot.org/uniprot/A0A674NL71 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:lypla1 ^@ http://purl.uniprot.org/uniprot/H2T0D9 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/31033:LOC101071076 ^@ http://purl.uniprot.org/uniprot/H2TQP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/31033:LOC101071814 ^@ http://purl.uniprot.org/uniprot/H2TNR6 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/31033:atp6v0b ^@ http://purl.uniprot.org/uniprot/H2UCX8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||clathrin-coated vesicle membrane http://togogenome.org/gene/31033:slc66a2 ^@ http://purl.uniprot.org/uniprot/A0A3B5K718|||http://purl.uniprot.org/uniprot/H2U6N7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:scrn3 ^@ http://purl.uniprot.org/uniprot/Q1KKU0 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/31033:LOC101077176 ^@ http://purl.uniprot.org/uniprot/A0A3B5K132 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/31033:il-18 ^@ http://purl.uniprot.org/uniprot/Q70T31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Cytoplasm|||Secreted http://togogenome.org/gene/31033:actbb ^@ http://purl.uniprot.org/uniprot/P53485 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.|||Belongs to the actin family.|||In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.|||Methylation at His-73 by SETD3. Methylation stabilizes actin filaments.|||N-terminal cleavage of acetylated methionine of immature cytoplasmic actin by ACTMAP.|||Nucleus|||Oxidation of Met-44 and Met-47 by MICALs (mical1, mical2 or mical3) to form methionine sulfoxide promotes actin filament depolymerization. Mical1 and mical2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by msrb1 and msrb2, which promote actin repolymerization.|||Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix (By similarity). Each actin can bind to 4 others (By similarity).|||There are three different beta-cytoplasmic actins in Fugu rubripes.|||cytoskeleton http://togogenome.org/gene/31033:ccm2 ^@ http://purl.uniprot.org/uniprot/H2SK82 ^@ Similarity ^@ Belongs to the CCM2 family. http://togogenome.org/gene/31033:LOC101075888 ^@ http://purl.uniprot.org/uniprot/H2U5R3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/31033:pcna ^@ http://purl.uniprot.org/uniprot/A0A3B5KHX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PCNA family.|||Nucleus|||This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. http://togogenome.org/gene/31033:cisd2 ^@ http://purl.uniprot.org/uniprot/H2TSJ9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CISD protein family. CISD2 subfamily.|||Binds 1 [2Fe-2S] cluster.|||Endoplasmic reticulum membrane|||Homodimer.|||Mitochondrion outer membrane|||Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. http://togogenome.org/gene/31033:LOC101068340 ^@ http://purl.uniprot.org/uniprot/H2SB17 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/31033:LOC101067383 ^@ http://purl.uniprot.org/uniprot/H2THA7 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/31033:LOC105417639 ^@ http://purl.uniprot.org/uniprot/A0A3B5K3E0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/31033:otx1 ^@ http://purl.uniprot.org/uniprot/H2TT89 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101076655 ^@ http://purl.uniprot.org/uniprot/H2UXD3 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with PTBP2; the interaction is direct.|||Nucleus http://togogenome.org/gene/31033:mindy3 ^@ http://purl.uniprot.org/uniprot/H2U7I8 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/31033:nkx6-1 ^@ http://purl.uniprot.org/uniprot/A0A674NPW5 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:prkx ^@ http://purl.uniprot.org/uniprot/A0A3B5K2K9|||http://purl.uniprot.org/uniprot/A0A674NUQ4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:LOC101067191 ^@ http://purl.uniprot.org/uniprot/H2SUG3 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/31033:LOC101071127 ^@ http://purl.uniprot.org/uniprot/H2SWC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RIX1/PELP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:c22h5orf22 ^@ http://purl.uniprot.org/uniprot/H2U311 ^@ Similarity ^@ Belongs to the UPF0489 family. http://togogenome.org/gene/31033:LOC100049638 ^@ http://purl.uniprot.org/uniprot/A0S0K8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101067942 ^@ http://purl.uniprot.org/uniprot/A0A674NPC9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/31033:sf3b5 ^@ http://purl.uniprot.org/uniprot/H2SM01 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SF3B5 family.|||Component of the spliceosome B complex.|||Nucleus http://togogenome.org/gene/31033:LOC101067990 ^@ http://purl.uniprot.org/uniprot/A0A3B5KM38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/31033:LOC101067689 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZJ6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/31033:LOC101077131 ^@ http://purl.uniprot.org/uniprot/H2S501 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/31033:p3h2 ^@ http://purl.uniprot.org/uniprot/H2V7Q6 ^@ Similarity ^@ Belongs to the leprecan family. http://togogenome.org/gene/31033:yars ^@ http://purl.uniprot.org/uniprot/H2UGK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Nucleus http://togogenome.org/gene/31033:LOC101063188 ^@ http://purl.uniprot.org/uniprot/H2V1R4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101079669 ^@ http://purl.uniprot.org/uniprot/H2URQ3 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/31033:crh ^@ http://purl.uniprot.org/uniprot/H2TBH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/31033:orc3 ^@ http://purl.uniprot.org/uniprot/H2SQM4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC3 family.|||Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.|||Nucleus http://togogenome.org/gene/31033:dcps ^@ http://purl.uniprot.org/uniprot/Q7T3R2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HIT family.|||Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.|||Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.|||Nucleus http://togogenome.org/gene/31033:mrps11 ^@ http://purl.uniprot.org/uniprot/A0A3B5KKP4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/31033:ndufa8 ^@ http://purl.uniprot.org/uniprot/H2RPM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA8 subunit family.|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/31033:snrpd2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KI36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/31033:nde1 ^@ http://purl.uniprot.org/uniprot/H2TQH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudE family.|||centrosome|||spindle http://togogenome.org/gene/31033:tmem170b ^@ http://purl.uniprot.org/uniprot/A0A3B5KR21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/31033:pkp4 ^@ http://purl.uniprot.org/uniprot/H2STJ6 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/31033:slc30a1 ^@ http://purl.uniprot.org/uniprot/Q5D1L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/31033:LOC101064109 ^@ http://purl.uniprot.org/uniprot/A0A674P1M7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/31033:LOC101063713 ^@ http://purl.uniprot.org/uniprot/A0A3B5K100 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/31033:scamp2 ^@ http://purl.uniprot.org/uniprot/H2UVV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/31033:chst14 ^@ http://purl.uniprot.org/uniprot/H2UT52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:LOC101073879 ^@ http://purl.uniprot.org/uniprot/A0A674PKE0 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:tmem41b ^@ http://purl.uniprot.org/uniprot/H2V5Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/31033:sdhaf3 ^@ http://purl.uniprot.org/uniprot/A0A674N3N6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I LYR family. SDHAF3 subfamily.|||Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. http://togogenome.org/gene/31033:LOC101068065 ^@ http://purl.uniprot.org/uniprot/H2TV82 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/31033:ildr2 ^@ http://purl.uniprot.org/uniprot/H2U5H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. LISCH7 family.|||Membrane|||tight junction http://togogenome.org/gene/31033:LOC101066951 ^@ http://purl.uniprot.org/uniprot/Q6E5T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/31033:hbp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KJ58 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. http://togogenome.org/gene/31033:pld4 ^@ http://purl.uniprot.org/uniprot/A0A674PIH7 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/31033:LOC101061635 ^@ http://purl.uniprot.org/uniprot/A0A674MX78|||http://purl.uniprot.org/uniprot/A0A674PNE8 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/31033:slc35a4 ^@ http://purl.uniprot.org/uniprot/H2SPA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:LOC101076940 ^@ http://purl.uniprot.org/uniprot/H2RUE5 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/31033:wdfy2 ^@ http://purl.uniprot.org/uniprot/A0A674MKJ0 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/31033:rell1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KLL4 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/31033:ramp2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KWN7 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/31033:pdss2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KAC7 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/31033:LOC101076647 ^@ http://purl.uniprot.org/uniprot/H2SK19 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.|||Membrane|||The cofactor is mostly bound to the substrate. http://togogenome.org/gene/31033:lamtor2 ^@ http://purl.uniprot.org/uniprot/A0A674N2R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAMAD family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/31033:LOC101064643 ^@ http://purl.uniprot.org/uniprot/H2UQQ0 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I family. http://togogenome.org/gene/31033:mcrip2 ^@ http://purl.uniprot.org/uniprot/H2U4W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCRIP family.|||Nucleus|||Stress granule http://togogenome.org/gene/31033:tfap2e ^@ http://purl.uniprot.org/uniprot/H2TCX9 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/31033:LOC101066275 ^@ http://purl.uniprot.org/uniprot/A0A3B5K2F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIb family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/31033:tspan7 ^@ http://purl.uniprot.org/uniprot/H2TGZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/31033:nqo1 ^@ http://purl.uniprot.org/uniprot/H2TZ89 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/31033:rpa3 ^@ http://purl.uniprot.org/uniprot/A0A3B5KKW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 3 family.|||Nucleus http://togogenome.org/gene/31033:tmem88b ^@ http://purl.uniprot.org/uniprot/H2TKD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM88 family.|||Membrane http://togogenome.org/gene/31033:LOC101079587 ^@ http://purl.uniprot.org/uniprot/A0A3B5KI73 ^@ Caution|||Similarity ^@ Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:aida ^@ http://purl.uniprot.org/uniprot/H2SQF6 ^@ Similarity ^@ Belongs to the AIDA family. http://togogenome.org/gene/31033:cldn3c ^@ http://purl.uniprot.org/uniprot/Q6E5S0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:lrp3 ^@ http://purl.uniprot.org/uniprot/H2TG01 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:aup1 ^@ http://purl.uniprot.org/uniprot/H2T0T8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AUP1 family.|||Membrane http://togogenome.org/gene/31033:usp48 ^@ http://purl.uniprot.org/uniprot/H2RKE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Nucleus http://togogenome.org/gene/31033:LOC101062285 ^@ http://purl.uniprot.org/uniprot/A0A674P105 ^@ Cofactor|||Similarity ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/31033:tac1 ^@ http://purl.uniprot.org/uniprot/A0A674NMH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted|||Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. http://togogenome.org/gene/31033:LOC101068976 ^@ http://purl.uniprot.org/uniprot/H2TCL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:prr15l ^@ http://purl.uniprot.org/uniprot/Q1KKW2 ^@ Similarity ^@ Belongs to the PRR15 family. http://togogenome.org/gene/31033:tfip11 ^@ http://purl.uniprot.org/uniprot/A1XDA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFP11/STIP family.|||Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events.|||Nucleus http://togogenome.org/gene/31033:nptn ^@ http://purl.uniprot.org/uniprot/A0A674N004 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:fbxo32 ^@ http://purl.uniprot.org/uniprot/H2SIP1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:pdc ^@ http://purl.uniprot.org/uniprot/H2SBF7 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/31033:LOC101066594 ^@ http://purl.uniprot.org/uniprot/A0A3B5KGW9 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101077403 ^@ http://purl.uniprot.org/uniprot/A0A3B5K812 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/31033:actr2 ^@ http://purl.uniprot.org/uniprot/A0A674PNI1 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/31033:LOC101073015 ^@ http://purl.uniprot.org/uniprot/A0A674NPI8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:zranb2 ^@ http://purl.uniprot.org/uniprot/H2S5N7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZRANB2 family.|||May interfere with constitutive 5'-splice site selection.|||Nucleus http://togogenome.org/gene/31033:tomm5 ^@ http://purl.uniprot.org/uniprot/A0A3B5K9E8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom5 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/31033:LOC101074111 ^@ http://purl.uniprot.org/uniprot/H2SSX9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101072167 ^@ http://purl.uniprot.org/uniprot/H2VEL0 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/31033:LOC101064053 ^@ http://purl.uniprot.org/uniprot/H2SNE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:ef-1a ^@ http://purl.uniprot.org/uniprot/Q4JF82 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/31033:tmod1 ^@ http://purl.uniprot.org/uniprot/A0A674P7X7 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/31033:LOC101074676 ^@ http://purl.uniprot.org/uniprot/H2S2D3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC446087 ^@ http://purl.uniprot.org/uniprot/A0A674PQS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/31033:mettl8 ^@ http://purl.uniprot.org/uniprot/A0A3B5KLH6 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/31033:LOC101074167 ^@ http://purl.uniprot.org/uniprot/H2RMQ8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:pcsk2 ^@ http://purl.uniprot.org/uniprot/A0A674P0J8 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/31033:hdac2 ^@ http://purl.uniprot.org/uniprot/A0A674PL70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/31033:slc22a2 ^@ http://purl.uniprot.org/uniprot/H2TCR6 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/31033:lhx1 ^@ http://purl.uniprot.org/uniprot/H2RJP6 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:cpa1 ^@ http://purl.uniprot.org/uniprot/Q8UW45 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/31033:fam20b ^@ http://purl.uniprot.org/uniprot/I7KJQ7 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/31033:LOC101071448 ^@ http://purl.uniprot.org/uniprot/H2RWK2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/31033:LOC101067851 ^@ http://purl.uniprot.org/uniprot/A0A674MCQ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:rap2a ^@ http://purl.uniprot.org/uniprot/A0A674NJP4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/31033:LOC101078860 ^@ http://purl.uniprot.org/uniprot/H2U7C7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:ythdc1 ^@ http://purl.uniprot.org/uniprot/H2TLH8 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/31033:pfdn5 ^@ http://purl.uniprot.org/uniprot/H2SYT7 ^@ Similarity ^@ Belongs to the prefoldin subunit alpha family. http://togogenome.org/gene/31033:eno1 ^@ http://purl.uniprot.org/uniprot/H2TDQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101066582 ^@ http://purl.uniprot.org/uniprot/H2V9P9 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/31033:ddx49 ^@ http://purl.uniprot.org/uniprot/A0A3B5KPM4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/31033:LOC101062232 ^@ http://purl.uniprot.org/uniprot/A0A674NZY7 ^@ Similarity ^@ Belongs to the BRAG family. http://togogenome.org/gene/31033:crcp ^@ http://purl.uniprot.org/uniprot/A0A3B5K3S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC9 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/31033:LOC101061711 ^@ http://purl.uniprot.org/uniprot/O13074 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Deformed subfamily.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101061656 ^@ http://purl.uniprot.org/uniprot/A0A3B5KIF3 ^@ Similarity ^@ Belongs to the isthmin family. http://togogenome.org/gene/31033:ogg1 ^@ http://purl.uniprot.org/uniprot/H2S698 ^@ Similarity ^@ Belongs to the type-1 OGG1 family. http://togogenome.org/gene/31033:pygl ^@ http://purl.uniprot.org/uniprot/H2T3Z9 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/31033:LOC101063498 ^@ http://purl.uniprot.org/uniprot/A0A674NU86 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/31033:idnk ^@ http://purl.uniprot.org/uniprot/A0A674MYG4 ^@ Similarity ^@ Belongs to the gluconokinase GntK/GntV family. http://togogenome.org/gene/31033:LOC101069359 ^@ http://purl.uniprot.org/uniprot/H2UL75 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of AMPK and MAPK1/2 signaling pathways.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/31033:LOC101079598 ^@ http://purl.uniprot.org/uniprot/A0A3B5KRU7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:LOC101078850 ^@ http://purl.uniprot.org/uniprot/H2V208 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM208 family.|||Endoplasmic reticulum membrane|||May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.|||Membrane http://togogenome.org/gene/31033:LOC101075984 ^@ http://purl.uniprot.org/uniprot/H2SBF9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:capzb ^@ http://purl.uniprot.org/uniprot/H2TJF7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the F-actin-capping protein beta subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit.|||cytoskeleton http://togogenome.org/gene/31033:mrpl18 ^@ http://purl.uniprot.org/uniprot/A0A3B5KJM9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL18 family. http://togogenome.org/gene/31033:LOC778000 ^@ http://purl.uniprot.org/uniprot/Q14DX6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:rbm46 ^@ http://purl.uniprot.org/uniprot/H2SCA9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:p2rx7 ^@ http://purl.uniprot.org/uniprot/H2TBX6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P2X receptor family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/31033:LOC101070118 ^@ http://purl.uniprot.org/uniprot/H2T501 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:KEF89_p08 ^@ http://purl.uniprot.org/uniprot/Q8HCW0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase A chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:srp14 ^@ http://purl.uniprot.org/uniprot/H2U9W4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP14 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm|||Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. http://togogenome.org/gene/31033:stk17b ^@ http://purl.uniprot.org/uniprot/A0A3B5K3N9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:mex3a ^@ http://purl.uniprot.org/uniprot/H2T3Y4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/31033:vbp1 ^@ http://purl.uniprot.org/uniprot/H2S6C4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/31033:LOC101064366 ^@ http://purl.uniprot.org/uniprot/A0A674NXM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/31033:LOC101076205 ^@ http://purl.uniprot.org/uniprot/H2TTW6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. http://togogenome.org/gene/31033:tgfb1i1 ^@ http://purl.uniprot.org/uniprot/H2SLI5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paxillin family.|||Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways.|||Nucleus matrix|||The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal.|||cytoskeleton|||focal adhesion http://togogenome.org/gene/31033:LOC101067100 ^@ http://purl.uniprot.org/uniprot/A0A674MZ07 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCR10/QCR9 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/31033:LOC101066440 ^@ http://purl.uniprot.org/uniprot/A0A674PFX7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101063127 ^@ http://purl.uniprot.org/uniprot/H2UEH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/31033:LOC101069338 ^@ http://purl.uniprot.org/uniprot/H2SLN8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101062244 ^@ http://purl.uniprot.org/uniprot/A0A674NYT4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101073358 ^@ http://purl.uniprot.org/uniprot/A0A3B5JUW3 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/31033:ankh ^@ http://purl.uniprot.org/uniprot/H2T9R1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANKH family.|||Membrane|||Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter. http://togogenome.org/gene/31033:LOC101077111 ^@ http://purl.uniprot.org/uniprot/A0A3B5KRU7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:LOC101062556 ^@ http://purl.uniprot.org/uniprot/A0A3B5K8J7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/31033:LOC101069879 ^@ http://purl.uniprot.org/uniprot/A0A674NGH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/31033:LOC101071237 ^@ http://purl.uniprot.org/uniprot/H2UTZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C26 family.|||extracellular space http://togogenome.org/gene/31033:slc50a1 ^@ http://purl.uniprot.org/uniprot/H2SYZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SWEET sugar transporter family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:tpt1 ^@ http://purl.uniprot.org/uniprot/H2VA86 ^@ Similarity ^@ Belongs to the TCTP family. http://togogenome.org/gene/31033:LOC101061990 ^@ http://purl.uniprot.org/uniprot/A0A3B5KH47 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/31033:LOC101066180 ^@ http://purl.uniprot.org/uniprot/A0A674MYD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/31033:LOC101076991 ^@ http://purl.uniprot.org/uniprot/H2RMA0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||nucleoplasm http://togogenome.org/gene/31033:tmem70 ^@ http://purl.uniprot.org/uniprot/A0A674NTK9 ^@ Similarity ^@ Belongs to the TMEM70 family. http://togogenome.org/gene/31033:LOC101078479 ^@ http://purl.uniprot.org/uniprot/H2UPN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:snta1 ^@ http://purl.uniprot.org/uniprot/A0A674N045 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||Cell junction|||cytoskeleton http://togogenome.org/gene/31033:LOC101070320 ^@ http://purl.uniprot.org/uniprot/H2V078 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/31033:ndor1 ^@ http://purl.uniprot.org/uniprot/H2T0C4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||Interacts with CIAPIN1; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair.|||perinuclear region http://togogenome.org/gene/31033:LOC101069150 ^@ http://purl.uniprot.org/uniprot/H2UMX2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. http://togogenome.org/gene/31033:LOC101078447 ^@ http://purl.uniprot.org/uniprot/A0A674MY27 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Cell membrane|||Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:gem ^@ http://purl.uniprot.org/uniprot/H2TM01 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/31033:hat1 ^@ http://purl.uniprot.org/uniprot/H2V8E9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HAT1 family.|||Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.|||Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). http://togogenome.org/gene/31033:LOC101070417 ^@ http://purl.uniprot.org/uniprot/A0A3B5KCW9 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:npffr2 ^@ http://purl.uniprot.org/uniprot/Q05KN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/31033:LOC101064422 ^@ http://purl.uniprot.org/uniprot/H2U7J4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/31033:LOC101075762 ^@ http://purl.uniprot.org/uniprot/A0A674NXT9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:parp1 ^@ http://purl.uniprot.org/uniprot/H2UJE1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARTD/PARP family.|||Chromosome|||Nucleus|||Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. http://togogenome.org/gene/31033:LOC101066441 ^@ http://purl.uniprot.org/uniprot/H2UHI7 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/31033:ppip5k1 ^@ http://purl.uniprot.org/uniprot/H2U8Z3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histidine acid phosphatase family. VIP1 subfamily.|||Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).|||cytosol http://togogenome.org/gene/31033:LOC101073338 ^@ http://purl.uniprot.org/uniprot/A0A674NCA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:ubac2 ^@ http://purl.uniprot.org/uniprot/H2TIA8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:mief1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K9H0 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/31033:LOC101063359 ^@ http://purl.uniprot.org/uniprot/A0A3B5K6E2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/31033:LOC101062836 ^@ http://purl.uniprot.org/uniprot/H2UWV6 ^@ Cofactor|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit. http://togogenome.org/gene/31033:LOC101071011 ^@ http://purl.uniprot.org/uniprot/H2SB21 ^@ Similarity ^@ Belongs to the LSM14 family. http://togogenome.org/gene/31033:rpl7l1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KIU2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/31033:LOC101066279 ^@ http://purl.uniprot.org/uniprot/H2TQJ8 ^@ Function|||Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. http://togogenome.org/gene/31033:LOC101061565 ^@ http://purl.uniprot.org/uniprot/A0A674NJ59 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/31033:kif19 ^@ http://purl.uniprot.org/uniprot/H2VA28 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/31033:asl ^@ http://purl.uniprot.org/uniprot/H2U7E4 ^@ Similarity ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. http://togogenome.org/gene/31033:LOC101063828 ^@ http://purl.uniprot.org/uniprot/A0A674NXK7 ^@ Similarity ^@ Belongs to the adaptor complexes medium subunit family. http://togogenome.org/gene/31033:frk ^@ http://purl.uniprot.org/uniprot/H2SSY6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/31033:mindy2 ^@ http://purl.uniprot.org/uniprot/H2V8P1 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM63 subfamily.|||Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. http://togogenome.org/gene/31033:skil ^@ http://purl.uniprot.org/uniprot/H2SJH9 ^@ Similarity ^@ Belongs to the SKI family. http://togogenome.org/gene/31033:keap1 ^@ http://purl.uniprot.org/uniprot/H2S9L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KEAP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:fdft1 ^@ http://purl.uniprot.org/uniprot/H2U1X3 ^@ Function|||Similarity ^@ Belongs to the phytoene/squalene synthase family.|||Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. http://togogenome.org/gene/31033:LOC101078639 ^@ http://purl.uniprot.org/uniprot/A0A3B5KKR4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL1 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/31033:tmem147 ^@ http://purl.uniprot.org/uniprot/A0A3B5KNE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM147 family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:LOC101076332 ^@ http://purl.uniprot.org/uniprot/A0A674MR92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/31033:opn3 ^@ http://purl.uniprot.org/uniprot/H2TX79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/31033:LOC101072451 ^@ http://purl.uniprot.org/uniprot/H2TPS6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/31033:LOC101075516 ^@ http://purl.uniprot.org/uniprot/A0A674NKC8 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/31033:acer1 ^@ http://purl.uniprot.org/uniprot/H2T6Q1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Membrane http://togogenome.org/gene/31033:LOC101077055 ^@ http://purl.uniprot.org/uniprot/H2VBS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/31033:LOC101073072 ^@ http://purl.uniprot.org/uniprot/A0A3B5KJI2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:LOC105416726 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MFAP family.|||extracellular matrix http://togogenome.org/gene/31033:tm4sf4 ^@ http://purl.uniprot.org/uniprot/H2VCA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/31033:ccn1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K3S9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/31033:LOC101078546 ^@ http://purl.uniprot.org/uniprot/H2V4K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/31033:pigh ^@ http://purl.uniprot.org/uniprot/A0A3B5K8G5 ^@ Similarity ^@ Belongs to the PIGH family. http://togogenome.org/gene/31033:snapin ^@ http://purl.uniprot.org/uniprot/H2SB13 ^@ Similarity ^@ Belongs to the SNAPIN family. http://togogenome.org/gene/31033:mettl1 ^@ http://purl.uniprot.org/uniprot/H2VDV7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Forms a complex with WDR4.|||Nucleus http://togogenome.org/gene/31033:LOC101078198 ^@ http://purl.uniprot.org/uniprot/H2T2S3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL1 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/31033:cers5 ^@ http://purl.uniprot.org/uniprot/A0A674MB01 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101077129 ^@ http://purl.uniprot.org/uniprot/H2U005 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/31033:krt222 ^@ http://purl.uniprot.org/uniprot/H2SXM1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/31033:LOC101074139 ^@ http://purl.uniprot.org/uniprot/H2UL04 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/31033:LOC101071194 ^@ http://purl.uniprot.org/uniprot/H2TK05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/31033:LOC101069919 ^@ http://purl.uniprot.org/uniprot/H2U5Y9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:casr ^@ http://purl.uniprot.org/uniprot/O73635 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:vps28 ^@ http://purl.uniprot.org/uniprot/A0A674PFG7 ^@ Function|||Similarity ^@ Belongs to the VPS28 family.|||Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. http://togogenome.org/gene/31033:tbx4 ^@ http://purl.uniprot.org/uniprot/H2T648 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/31033:fbln7 ^@ http://purl.uniprot.org/uniprot/H2U6E6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:sord ^@ http://purl.uniprot.org/uniprot/A0A674NDX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the zinc-containing alcohol dehydrogenase family.|||Mitochondrion membrane|||flagellum http://togogenome.org/gene/31033:hmgcr ^@ http://purl.uniprot.org/uniprot/H2U9D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMG-CoA reductase family.|||Endoplasmic reticulum membrane|||Membrane|||Peroxisome membrane http://togogenome.org/gene/31033:LOC101072783 ^@ http://purl.uniprot.org/uniprot/H2U0D4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. http://togogenome.org/gene/31033:hm13 ^@ http://purl.uniprot.org/uniprot/H2SSI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Membrane http://togogenome.org/gene/31033:tle3 ^@ http://purl.uniprot.org/uniprot/Q3LFR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/31033:LOC105417541 ^@ http://purl.uniprot.org/uniprot/A0A3B5K930 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/31033:tpm3 ^@ http://purl.uniprot.org/uniprot/Q805C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/31033:LOC101071352 ^@ http://purl.uniprot.org/uniprot/A0A3B5KN53 ^@ Similarity ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily. http://togogenome.org/gene/31033:LOC101070414 ^@ http://purl.uniprot.org/uniprot/A0A674PNA8 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by DAG and phorbol esters.|||Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/31033:slc9a3 ^@ http://purl.uniprot.org/uniprot/H2U4K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Membrane|||Recycling endosome membrane http://togogenome.org/gene/31033:LOC101078123 ^@ http://purl.uniprot.org/uniprot/H2SR25 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101078924 ^@ http://purl.uniprot.org/uniprot/Q2PR31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101073058 ^@ http://purl.uniprot.org/uniprot/A0A674P6Y4 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/31033:rhbdl3 ^@ http://purl.uniprot.org/uniprot/A0A674P3B4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.|||Membrane http://togogenome.org/gene/31033:ppfia1 ^@ http://purl.uniprot.org/uniprot/H2T387 ^@ Similarity ^@ Belongs to the liprin family. Liprin-alpha subfamily. http://togogenome.org/gene/31033:LOC101067123 ^@ http://purl.uniprot.org/uniprot/H2U0K0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 14 family. XylT subfamily.|||Golgi apparatus membrane|||Membrane|||Monomer. http://togogenome.org/gene/31033:LOC101070635 ^@ http://purl.uniprot.org/uniprot/A0A674NBA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/31033:psip1 ^@ http://purl.uniprot.org/uniprot/H2TKQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HDGF family.|||Nucleus http://togogenome.org/gene/31033:st6galnac3 ^@ http://purl.uniprot.org/uniprot/Q50J45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/31033:thoc7 ^@ http://purl.uniprot.org/uniprot/A0A674PN97 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC7 family.|||Nucleus|||Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. http://togogenome.org/gene/31033:cacng1 ^@ http://purl.uniprot.org/uniprot/H2RN58 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.|||Membrane|||Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.|||sarcolemma http://togogenome.org/gene/31033:LOC101077821 ^@ http://purl.uniprot.org/uniprot/A0A3B5K9J7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101079868 ^@ http://purl.uniprot.org/uniprot/Q2PR10 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101077727 ^@ http://purl.uniprot.org/uniprot/A0A3B5KTK8 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/31033:ap2s1 ^@ http://purl.uniprot.org/uniprot/A0A674N9K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cell membrane|||coated pit http://togogenome.org/gene/31033:wnt4 ^@ http://purl.uniprot.org/uniprot/A0A674MAV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/31033:LOC101067856 ^@ http://purl.uniprot.org/uniprot/A0A3B5KGR1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/31033:hvcn1 ^@ http://purl.uniprot.org/uniprot/H2S3D2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hydrogen channel family.|||Homodimer.|||Membrane http://togogenome.org/gene/31033:pcyt1a ^@ http://purl.uniprot.org/uniprot/A0A674N078 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/31033:LOC101070680 ^@ http://purl.uniprot.org/uniprot/A0A3B5KLV8 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/31033:leprotl1 ^@ http://purl.uniprot.org/uniprot/B3Y065 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/31033:LOC101076568 ^@ http://purl.uniprot.org/uniprot/H2UXT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Cell membrane|||Cytoplasmic vesicle|||Endosome|||Membrane|||Perikaryon|||Recycling endosome|||Synaptic cell membrane|||Vesicle|||dendrite http://togogenome.org/gene/31033:ndufaf7 ^@ http://purl.uniprot.org/uniprot/H2USL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Belongs to the NDUFAF7 family.|||Mitochondrion http://togogenome.org/gene/31033:LOC101064687 ^@ http://purl.uniprot.org/uniprot/H2UBJ0 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/31033:cacnb4 ^@ http://purl.uniprot.org/uniprot/B6IDF1|||http://purl.uniprot.org/uniprot/B6IDF2 ^@ Similarity ^@ Belongs to the calcium channel beta subunit family. http://togogenome.org/gene/31033:LOC101073419 ^@ http://purl.uniprot.org/uniprot/A0A674MB33 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.|||Membrane|||The cofactor is mostly bound to the substrate. http://togogenome.org/gene/31033:LOC101072385 ^@ http://purl.uniprot.org/uniprot/H2TCA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/31033:LOC101067604 ^@ http://purl.uniprot.org/uniprot/H2SQS0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/31033:prdm1 ^@ http://purl.uniprot.org/uniprot/Q75UA3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.|||Nucleus|||Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. http://togogenome.org/gene/31033:trmt2a ^@ http://purl.uniprot.org/uniprot/H2UCA1 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101071886 ^@ http://purl.uniprot.org/uniprot/H2UXD9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/31033:acot8 ^@ http://purl.uniprot.org/uniprot/H2RQ17 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/31033:hsd17b1 ^@ http://purl.uniprot.org/uniprot/H2UPG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Favors the reduction of estrogens and androgens. Uses preferentially NADH. http://togogenome.org/gene/31033:pde1b ^@ http://purl.uniprot.org/uniprot/A0A3B5KNL2 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/31033:LOC101072418 ^@ http://purl.uniprot.org/uniprot/A0A674PCM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the band 7/mec-2 family.|||Membrane http://togogenome.org/gene/31033:LOC101080081 ^@ http://purl.uniprot.org/uniprot/A0A3B5KGD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/31033:LOC101076426 ^@ http://purl.uniprot.org/uniprot/A0A674P1G9 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/31033:prl ^@ http://purl.uniprot.org/uniprot/H2U4C4|||http://purl.uniprot.org/uniprot/Q1HAY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/31033:LOC101064257 ^@ http://purl.uniprot.org/uniprot/H2U5X2 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/31033:dpm1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KV61 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum|||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. http://togogenome.org/gene/31033:LOC101067147 ^@ http://purl.uniprot.org/uniprot/H2V2F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FOXJ1 family.|||Nucleus http://togogenome.org/gene/31033:hsf1 ^@ http://purl.uniprot.org/uniprot/H2RK44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/31033:rad50 ^@ http://purl.uniprot.org/uniprot/H2S8G2 ^@ Similarity ^@ Belongs to the SMC family. RAD50 subfamily. http://togogenome.org/gene/31033:LOC101069073 ^@ http://purl.uniprot.org/uniprot/Q8JG01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101079484 ^@ http://purl.uniprot.org/uniprot/H2RVP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:slc39a3 ^@ http://purl.uniprot.org/uniprot/Q6QQT0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:ppp4c ^@ http://purl.uniprot.org/uniprot/H2TWI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/31033:diras1 ^@ http://purl.uniprot.org/uniprot/A0A674NHJ9 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/31033:LOC101074826 ^@ http://purl.uniprot.org/uniprot/A0A674MIU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/31033:mettl3 ^@ http://purl.uniprot.org/uniprot/H2UQP4 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/31033:LOC101068771 ^@ http://purl.uniprot.org/uniprot/H2SSW6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/31033:LOC101066203 ^@ http://purl.uniprot.org/uniprot/A0A674MVS5 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/31033:atp6v1h ^@ http://purl.uniprot.org/uniprot/H2TWA1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/31033:serpini1 ^@ http://purl.uniprot.org/uniprot/H2U3L2 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/31033:slc5a3 ^@ http://purl.uniprot.org/uniprot/H2TVI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/31033:LOC101069099 ^@ http://purl.uniprot.org/uniprot/H2RK05 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/31033:ca12 ^@ http://purl.uniprot.org/uniprot/A0A6D2XSH9 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/31033:LOC101073614 ^@ http://purl.uniprot.org/uniprot/A0A674N6W6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:ythdf3 ^@ http://purl.uniprot.org/uniprot/H2T4I3 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/31033:LOC101062077 ^@ http://purl.uniprot.org/uniprot/H2UR44 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/31033:LOC105416602 ^@ http://purl.uniprot.org/uniprot/A0A3B5JY81 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101064407 ^@ http://purl.uniprot.org/uniprot/H2TR38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:ykt6 ^@ http://purl.uniprot.org/uniprot/A0A3B5K6P9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. http://togogenome.org/gene/31033:LOC101077456 ^@ http://purl.uniprot.org/uniprot/H2SC53 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/31033:LOC101070662 ^@ http://purl.uniprot.org/uniprot/H2TA25 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/31033:cmpk1 ^@ http://purl.uniprot.org/uniprot/H2RXA2 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.|||Binds 1 Mg(2+) ion per monomer.|||Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/31033:fam168b ^@ http://purl.uniprot.org/uniprot/H2SWU9 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/31033:selenbp1 ^@ http://purl.uniprot.org/uniprot/H2T2U7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selenium-binding protein family.|||Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.|||Membrane|||Nucleus|||cytosol http://togogenome.org/gene/31033:chmp1b ^@ http://purl.uniprot.org/uniprot/H2UDT8 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/31033:foxb2 ^@ http://purl.uniprot.org/uniprot/A0A3B5K816 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:stk11 ^@ http://purl.uniprot.org/uniprot/H2TJI9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily. http://togogenome.org/gene/31033:bgn ^@ http://purl.uniprot.org/uniprot/H2THK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||May be involved in collagen fiber assembly.|||extracellular matrix http://togogenome.org/gene/31033:napg ^@ http://purl.uniprot.org/uniprot/A0A3B5K9T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane http://togogenome.org/gene/31033:hpx ^@ http://purl.uniprot.org/uniprot/Q75UL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hemopexin family.|||Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.|||Secreted http://togogenome.org/gene/31033:LOC101061713 ^@ http://purl.uniprot.org/uniprot/A0A3B5K600|||http://purl.uniprot.org/uniprot/A0A674NHP4|||http://purl.uniprot.org/uniprot/H2TWX6|||http://purl.uniprot.org/uniprot/H2TWX9 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/31033:hoxc11 ^@ http://purl.uniprot.org/uniprot/Q1KKV2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:c12h18orf21 ^@ http://purl.uniprot.org/uniprot/A0A3B5JYK4 ^@ Similarity ^@ Belongs to the UPF0711 family. http://togogenome.org/gene/31033:vps4a ^@ http://purl.uniprot.org/uniprot/H2S5W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/31033:abitram ^@ http://purl.uniprot.org/uniprot/A0A3B5KB98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABITRAM family.|||growth cone|||lamellipodium http://togogenome.org/gene/31033:LOC101079369 ^@ http://purl.uniprot.org/uniprot/H2U5V8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Nucleus|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/31033:letm2 ^@ http://purl.uniprot.org/uniprot/H2UZA8 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/31033:LOC101064562 ^@ http://purl.uniprot.org/uniprot/A0A3B5KGR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:kdm2a ^@ http://purl.uniprot.org/uniprot/H2UF78 ^@ Similarity ^@ Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. http://togogenome.org/gene/31033:ppp2r5a ^@ http://purl.uniprot.org/uniprot/A0A3B5JZS8 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family. http://togogenome.org/gene/31033:cth ^@ http://purl.uniprot.org/uniprot/A0A674MWJ6 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/31033:LOC101079172 ^@ http://purl.uniprot.org/uniprot/A0A3B5JYB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/31033:npl ^@ http://purl.uniprot.org/uniprot/H2V8I4 ^@ Similarity|||Subunit ^@ Belongs to the DapA family.|||Homotetramer. http://togogenome.org/gene/31033:vipr1 ^@ http://purl.uniprot.org/uniprot/A0A674MA68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101076827 ^@ http://purl.uniprot.org/uniprot/H2UDB2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:exoc2 ^@ http://purl.uniprot.org/uniprot/H2RVL5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SEC5 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||Component of the exocyst complex. http://togogenome.org/gene/31033:LOC101074393 ^@ http://purl.uniprot.org/uniprot/A0A674PDB6 ^@ Similarity ^@ Belongs to the TACO1 family. http://togogenome.org/gene/31033:mkx ^@ http://purl.uniprot.org/uniprot/A0A674NWQ3 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:tmem165 ^@ http://purl.uniprot.org/uniprot/H2URJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GDT1 family.|||Membrane http://togogenome.org/gene/31033:rpl6 ^@ http://purl.uniprot.org/uniprot/H2UYH6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/31033:tmem9b ^@ http://purl.uniprot.org/uniprot/A0A3B5K4J5 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/31033:ltbp3 ^@ http://purl.uniprot.org/uniprot/H2V0P3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/31033:itpkb ^@ http://purl.uniprot.org/uniprot/H2UH00 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/31033:taf11 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZU1 ^@ Similarity ^@ Belongs to the TAF11 family. http://togogenome.org/gene/31033:arrdc2 ^@ http://purl.uniprot.org/uniprot/H2S8P7 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/31033:trappc1 ^@ http://purl.uniprot.org/uniprot/A0A674MS07 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/31033:LOC101076158 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZR6 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/31033:LOC101066898 ^@ http://purl.uniprot.org/uniprot/A0A674P4E9 ^@ Subcellular Location Annotation ^@ Mitochondrion intermembrane space http://togogenome.org/gene/31033:cd82 ^@ http://purl.uniprot.org/uniprot/H2V399 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/31033:LOC101072929 ^@ http://purl.uniprot.org/uniprot/Q6WNT5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101078575 ^@ http://purl.uniprot.org/uniprot/H2TED7 ^@ Cofactor ^@ Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain. http://togogenome.org/gene/31033:nit1 ^@ http://purl.uniprot.org/uniprot/H2SD88 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/31033:LOC101071044 ^@ http://purl.uniprot.org/uniprot/H2UYG0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the fibulin family.|||Homomultimerizes and interacts with various extracellular matrix components.|||Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/31033:wtap ^@ http://purl.uniprot.org/uniprot/H2SKQ0 ^@ Similarity ^@ Belongs to the fl(2)d family. http://togogenome.org/gene/31033:pgk1 ^@ http://purl.uniprot.org/uniprot/H2SMR9 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/31033:faxc ^@ http://purl.uniprot.org/uniprot/H2RK94 ^@ Similarity ^@ Belongs to the FAX family. http://togogenome.org/gene/31033:camk2n2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KFL5 ^@ Similarity ^@ Belongs to the CAMK2N family. http://togogenome.org/gene/31033:LOC101064934 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZ28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/31033:LOC101062358 ^@ http://purl.uniprot.org/uniprot/H2TY87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/31033:mmp9 ^@ http://purl.uniprot.org/uniprot/Q4JF83 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||extracellular matrix http://togogenome.org/gene/31033:lsm4 ^@ http://purl.uniprot.org/uniprot/A0A3B5K599 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/31033:ubald2 ^@ http://purl.uniprot.org/uniprot/A0A674N867 ^@ Similarity ^@ Belongs to the UBALD family. http://togogenome.org/gene/31033:emc4 ^@ http://purl.uniprot.org/uniprot/H2SJH5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC4 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:tmt-opsin ^@ http://purl.uniprot.org/uniprot/Q8JI05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/31033:LOC101075256 ^@ http://purl.uniprot.org/uniprot/A0A3B5JUK8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex.|||Endoplasmic reticulum membrane|||Membrane|||The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (By similarity). The SEC61 channel associates with the multi-pass translocon (MPT) complex. http://togogenome.org/gene/31033:sfxn5 ^@ http://purl.uniprot.org/uniprot/A0A674NYQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/31033:rpl36a ^@ http://purl.uniprot.org/uniprot/P61486 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm http://togogenome.org/gene/31033:pdik1l ^@ http://purl.uniprot.org/uniprot/A0A3B5KRP8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:nt5c3b ^@ http://purl.uniprot.org/uniprot/A0A3B5KKE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/31033:mapk8ip1 ^@ http://purl.uniprot.org/uniprot/H2UWP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JIP scaffold family.|||Cytoplasm http://togogenome.org/gene/31033:tas2r1 ^@ http://purl.uniprot.org/uniprot/Q2MHJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/31033:LOC101078429 ^@ http://purl.uniprot.org/uniprot/H2RJ92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/31033:mrpl34 ^@ http://purl.uniprot.org/uniprot/A0A674N9R0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/31033:folh1b ^@ http://purl.uniprot.org/uniprot/H2T9B8|||http://purl.uniprot.org/uniprot/H2T9B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:mfsd11 ^@ http://purl.uniprot.org/uniprot/H2RVG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/31033:actr10 ^@ http://purl.uniprot.org/uniprot/H2TVB4 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/31033:LOC101074159 ^@ http://purl.uniprot.org/uniprot/H2T1J4 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/31033:LOC101073337 ^@ http://purl.uniprot.org/uniprot/A0A674NH25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the neuropeptide B/W family.|||Secreted http://togogenome.org/gene/31033:onecut2 ^@ http://purl.uniprot.org/uniprot/H2RNA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101077246 ^@ http://purl.uniprot.org/uniprot/H2RR32 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:edem3 ^@ http://purl.uniprot.org/uniprot/A0A674NGB8|||http://purl.uniprot.org/uniprot/H2V8H1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/31033:hdac4 ^@ http://purl.uniprot.org/uniprot/A0A674MXL2|||http://purl.uniprot.org/uniprot/A0A674N687|||http://purl.uniprot.org/uniprot/A0A674PFX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. http://togogenome.org/gene/31033:nlgn4a ^@ http://purl.uniprot.org/uniprot/D2X2H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:pptc7 ^@ http://purl.uniprot.org/uniprot/A0A3B5K8P1 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/31033:LOC101064780 ^@ http://purl.uniprot.org/uniprot/A0A3B5KFQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/31033:kcns2 ^@ http://purl.uniprot.org/uniprot/H2TT92 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101062207 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZD7|||http://purl.uniprot.org/uniprot/A0A3B5KGK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/31033:gtf2h3 ^@ http://purl.uniprot.org/uniprot/A0A3B5KCS4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB4 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.|||Nucleus|||Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7. http://togogenome.org/gene/31033:irx3 ^@ http://purl.uniprot.org/uniprot/A0A3B5KD74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101068531 ^@ http://purl.uniprot.org/uniprot/H2U7W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/31033:LOC101077558 ^@ http://purl.uniprot.org/uniprot/A0A674MTZ1 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/31033:nt5c3a ^@ http://purl.uniprot.org/uniprot/A0A674N3B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/31033:LOC445926 ^@ http://purl.uniprot.org/uniprot/P61133 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 23 family. http://togogenome.org/gene/31033:cfap300 ^@ http://purl.uniprot.org/uniprot/A0A3B5K580 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP300 family.|||Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.|||Cytoplasm http://togogenome.org/gene/31033:LOC101076576 ^@ http://purl.uniprot.org/uniprot/H2URZ6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:sec61a1 ^@ http://purl.uniprot.org/uniprot/H2TCB5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex.|||Endoplasmic reticulum membrane|||Membrane|||The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (By similarity). The SEC61 channel associates with the multi-pass translocon (MPT) complex. http://togogenome.org/gene/31033:ca7 ^@ http://purl.uniprot.org/uniprot/A0A510ADZ2|||http://purl.uniprot.org/uniprot/H2V4P5 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/31033:c8g ^@ http://purl.uniprot.org/uniprot/H2RU50 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/31033:kcnc4 ^@ http://purl.uniprot.org/uniprot/H2S8X6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:plpbp ^@ http://purl.uniprot.org/uniprot/H2S9R8 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. http://togogenome.org/gene/31033:LOC101062422 ^@ http://purl.uniprot.org/uniprot/H2VDP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM198 family.|||Membrane http://togogenome.org/gene/31033:dolk ^@ http://purl.uniprot.org/uniprot/A0A3B5KM43 ^@ Similarity ^@ Belongs to the polyprenol kinase family. http://togogenome.org/gene/31033:st7 ^@ http://purl.uniprot.org/uniprot/Q8UW40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/31033:LOC101063426 ^@ http://purl.uniprot.org/uniprot/H2TNC7 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/31033:ssr3 ^@ http://purl.uniprot.org/uniprot/A0A674P9Q8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-gamma family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/31033:stat1 ^@ http://purl.uniprot.org/uniprot/H2RJB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:LOC101072247 ^@ http://purl.uniprot.org/uniprot/A0A3B5JY66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP1R35 family.|||centriole http://togogenome.org/gene/31033:rpl23 ^@ http://purl.uniprot.org/uniprot/A0A674N2U7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/31033:LOC101061744 ^@ http://purl.uniprot.org/uniprot/A0A3B5K553 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/31033:btbd10 ^@ http://purl.uniprot.org/uniprot/H2V6F6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:ppib ^@ http://purl.uniprot.org/uniprot/A0A3B5K4E5 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/31033:srp9 ^@ http://purl.uniprot.org/uniprot/A0A674NVN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP9 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm http://togogenome.org/gene/31033:cmas ^@ http://purl.uniprot.org/uniprot/Q53IM5 ^@ Similarity ^@ Belongs to the CMP-NeuNAc synthase family. http://togogenome.org/gene/31033:tbx2 ^@ http://purl.uniprot.org/uniprot/H2T7W6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/31033:LOC101074129 ^@ http://purl.uniprot.org/uniprot/A0A3B5KB46 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:susd4 ^@ http://purl.uniprot.org/uniprot/A0A3B5KKJ7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:cers6 ^@ http://purl.uniprot.org/uniprot/A0A674MZB9 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:eif4a2 ^@ http://purl.uniprot.org/uniprot/A0A3B5K7V9 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/31033:LOC101074542 ^@ http://purl.uniprot.org/uniprot/A0A1Q0XE16 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/31033:LOC101070634 ^@ http://purl.uniprot.org/uniprot/A0A3B5K7B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.|||Nucleus|||centromere http://togogenome.org/gene/31033:wsb1 ^@ http://purl.uniprot.org/uniprot/Q9W5Z5 ^@ Domain|||Function|||Subunit ^@ Component of a probable ECS E3 ubiquitin-protein ligase complex that contains the Elongin BC complex.|||Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.|||The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. http://togogenome.org/gene/31033:KEF89_p04 ^@ http://purl.uniprot.org/uniprot/Q8HCV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/31033:LOC101077775 ^@ http://purl.uniprot.org/uniprot/H2SC36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/31033:LOC101070203 ^@ http://purl.uniprot.org/uniprot/A0A3B5K744 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM198 family.|||Membrane http://togogenome.org/gene/31033:sfrp2 ^@ http://purl.uniprot.org/uniprot/A0A674MHV1 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:mag ^@ http://purl.uniprot.org/uniprot/Q5W431|||http://purl.uniprot.org/uniprot/Q5W435|||http://purl.uniprot.org/uniprot/Q5W436 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101077970 ^@ http://purl.uniprot.org/uniprot/H2U7N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/31033:lrrc8a ^@ http://purl.uniprot.org/uniprot/H2VCE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:atp5po ^@ http://purl.uniprot.org/uniprot/A0A674N7X8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:KEF89_p10 ^@ http://purl.uniprot.org/uniprot/Q8HCW2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/31033:LOC101067313 ^@ http://purl.uniprot.org/uniprot/A0A674N951 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/31033:LOC101076059 ^@ http://purl.uniprot.org/uniprot/H2T8S3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/31033:mrps24 ^@ http://purl.uniprot.org/uniprot/A0A674MIN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Mitochondrion http://togogenome.org/gene/31033:wdfy1 ^@ http://purl.uniprot.org/uniprot/H2TMU4 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/31033:LOC101071898 ^@ http://purl.uniprot.org/uniprot/H2UYF1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit beta family.|||Heterodimer of an alpha and a beta chain.|||Involved in gametogenesis and steroidogenesis.|||Secreted http://togogenome.org/gene/31033:LOC101072576 ^@ http://purl.uniprot.org/uniprot/H2TUP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.|||Secreted http://togogenome.org/gene/31033:myf5 ^@ http://purl.uniprot.org/uniprot/Q6SYV6 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/31033:LOC101078946 ^@ http://purl.uniprot.org/uniprot/H2UGL2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/31033:LOC105417861 ^@ http://purl.uniprot.org/uniprot/A0A3B5KHX0 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:fam118b ^@ http://purl.uniprot.org/uniprot/H2SVP1 ^@ Similarity ^@ Belongs to the FAM118 family. http://togogenome.org/gene/31033:nagk ^@ http://purl.uniprot.org/uniprot/H2T5Q9 ^@ Similarity ^@ Belongs to the eukaryotic-type N-acetylglucosamine kinase family. http://togogenome.org/gene/31033:cct5 ^@ http://purl.uniprot.org/uniprot/H2TF92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101065417 ^@ http://purl.uniprot.org/uniprot/A0A674NUH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/31033:LOC105417793 ^@ http://purl.uniprot.org/uniprot/A0A3B5K0S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/31033:fmr1 ^@ http://purl.uniprot.org/uniprot/A0A674N8X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMR1 family.|||Cell membrane|||Cytoplasmic ribonucleoprotein granule|||Membrane|||Perikaryon|||Presynaptic cell membrane|||Synaptic cell membrane|||axon|||centromere|||dendrite|||dendritic spine|||filopodium tip|||growth cone|||neuron projection|||nucleolus|||perinuclear region|||synaptosome http://togogenome.org/gene/31033:ip6k2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KG02 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/31033:LOC101068259 ^@ http://purl.uniprot.org/uniprot/H2SM96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/31033:elovl5 ^@ http://purl.uniprot.org/uniprot/H2UNL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/31033:supt3h ^@ http://purl.uniprot.org/uniprot/H2SSR2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101073848 ^@ http://purl.uniprot.org/uniprot/A0A3B5KM22 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:pde5a ^@ http://purl.uniprot.org/uniprot/A0A674P1B4 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/31033:LOC101067076 ^@ http://purl.uniprot.org/uniprot/H2SL68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:fut4 ^@ http://purl.uniprot.org/uniprot/Q70AH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/31033:LOC101064351 ^@ http://purl.uniprot.org/uniprot/A0A3B5JVH0|||http://purl.uniprot.org/uniprot/H2UKW0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:cldn11b ^@ http://purl.uniprot.org/uniprot/Q6E5T2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:LOC101073508 ^@ http://purl.uniprot.org/uniprot/H2SC68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/31033:LOC101075052 ^@ http://purl.uniprot.org/uniprot/A0A674MYK0 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/31033:nsdhl ^@ http://purl.uniprot.org/uniprot/H2TFD0 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/31033:foxk1 ^@ http://purl.uniprot.org/uniprot/H2U199 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:pdcd5 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZD0 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/31033:LOC101067618 ^@ http://purl.uniprot.org/uniprot/Q1L0L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/31033:LOC101063122 ^@ http://purl.uniprot.org/uniprot/A0A674MBK7 ^@ Similarity ^@ Belongs to the BicD family. http://togogenome.org/gene/31033:LOC101066863 ^@ http://purl.uniprot.org/uniprot/H2UT22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/31033:mpg ^@ http://purl.uniprot.org/uniprot/H2TVW0 ^@ Function|||Similarity ^@ Belongs to the DNA glycosylase MPG family.|||Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. http://togogenome.org/gene/31033:hgs ^@ http://purl.uniprot.org/uniprot/H2TYB1 ^@ Subcellular Location Annotation ^@ Early endosome membrane http://togogenome.org/gene/31033:hspb8 ^@ http://purl.uniprot.org/uniprot/H2UWV9 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/31033:LOC101064136 ^@ http://purl.uniprot.org/uniprot/H2U2D8 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/31033:LOC101073672 ^@ http://purl.uniprot.org/uniprot/A0A3B5KLY3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2). Component of the SAGA transcription coactivator-HAT complex. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.|||nucleoplasm http://togogenome.org/gene/31033:thbs1 ^@ http://purl.uniprot.org/uniprot/H2UJX9 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101077107 ^@ http://purl.uniprot.org/uniprot/H2TQM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMR1 family.|||Cytoplasmic ribonucleoprotein granule http://togogenome.org/gene/31033:polr3b ^@ http://purl.uniprot.org/uniprot/H2TAU9 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/31033:LOC101066344 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||clathrin-coated pit http://togogenome.org/gene/31033:gipc1 ^@ http://purl.uniprot.org/uniprot/H2U7J7 ^@ Similarity ^@ Belongs to the GIPC family. http://togogenome.org/gene/31033:LOC101067113 ^@ http://purl.uniprot.org/uniprot/A0A674MEI1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:nudt21 ^@ http://purl.uniprot.org/uniprot/H2V9Y4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family. CPSF5 subfamily.|||Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.|||Cytoplasm|||Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.|||Nucleus http://togogenome.org/gene/31033:LOC101065152 ^@ http://purl.uniprot.org/uniprot/A0A6D2XZU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/31033:fbxo45 ^@ http://purl.uniprot.org/uniprot/H2SXP9 ^@ Similarity ^@ Belongs to the FBXO45/Fsn family. http://togogenome.org/gene/31033:LOC100653419 ^@ http://purl.uniprot.org/uniprot/E9LZ00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/31033:zdhhc3 ^@ http://purl.uniprot.org/uniprot/H2T6R5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/31033:mtg2 ^@ http://purl.uniprot.org/uniprot/H2RTV8 ^@ Similarity ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. http://togogenome.org/gene/31033:inpp5d ^@ http://purl.uniprot.org/uniprot/H2RSB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.|||Membrane http://togogenome.org/gene/31033:nf2 ^@ http://purl.uniprot.org/uniprot/H2UYK2 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/31033:LOC101066598 ^@ http://purl.uniprot.org/uniprot/H2UK77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/31033:map2k2 ^@ http://purl.uniprot.org/uniprot/A0A674N3S8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:LOC101079885 ^@ http://purl.uniprot.org/uniprot/H2U9Y3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:derl2 ^@ http://purl.uniprot.org/uniprot/A0A3B5JXJ8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:tpra1 ^@ http://purl.uniprot.org/uniprot/A0A674MNX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0359 family.|||Membrane http://togogenome.org/gene/31033:fabp1 ^@ http://purl.uniprot.org/uniprot/H2USJ2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.|||Cytoplasm|||Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. http://togogenome.org/gene/31033:taf10 ^@ http://purl.uniprot.org/uniprot/H2UQS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF10 family.|||Nucleus|||The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. http://togogenome.org/gene/31033:atg9a ^@ http://purl.uniprot.org/uniprot/Q3T8Y8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG9 family.|||Membrane|||Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.|||Preautophagosomal structure membrane http://togogenome.org/gene/31033:med10 ^@ http://purl.uniprot.org/uniprot/A0A3B5KIZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 10 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/31033:LOC101070694 ^@ http://purl.uniprot.org/uniprot/H2RUY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:elovl7 ^@ http://purl.uniprot.org/uniprot/A0A674NAA0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL7 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:vldlr ^@ http://purl.uniprot.org/uniprot/H2SFQ8|||http://purl.uniprot.org/uniprot/H2SFR2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:cand1 ^@ http://purl.uniprot.org/uniprot/H2SPV9 ^@ Similarity ^@ Belongs to the CAND family. http://togogenome.org/gene/31033:tp63 ^@ http://purl.uniprot.org/uniprot/H2S6K4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.|||Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.|||Nucleus http://togogenome.org/gene/31033:mct4b ^@ http://purl.uniprot.org/uniprot/E7FKY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/31033:LOC101061361 ^@ http://purl.uniprot.org/uniprot/A0A674PFR1 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/31033:cldn29a ^@ http://purl.uniprot.org/uniprot/Q6E5R5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:LOC101077904 ^@ http://purl.uniprot.org/uniprot/A0A674NYM0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101062993 ^@ http://purl.uniprot.org/uniprot/A0A3B5KMJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/31033:vps72 ^@ http://purl.uniprot.org/uniprot/H2SQW8 ^@ Function|||Similarity ^@ Belongs to the VPS72/YL1 family.|||Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. http://togogenome.org/gene/31033:mrps16 ^@ http://purl.uniprot.org/uniprot/A0A674NFC3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/31033:dnajc16 ^@ http://purl.uniprot.org/uniprot/H2V883 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Plays an important role in regulating the size of autophagosomes during the formation process. http://togogenome.org/gene/31033:trpv6 ^@ http://purl.uniprot.org/uniprot/Q7T2Z4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101073733 ^@ http://purl.uniprot.org/uniprot/A0A674MI79|||http://purl.uniprot.org/uniprot/A0A674NKU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Membrane|||Midbody|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. http://togogenome.org/gene/31033:rftn2 ^@ http://purl.uniprot.org/uniprot/H2USU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:polr2d ^@ http://purl.uniprot.org/uniprot/H2SFV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/31033:vps4b ^@ http://purl.uniprot.org/uniprot/A0A3B5K431 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/31033:rh30-like ^@ http://purl.uniprot.org/uniprot/Q7T3R3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Cell membrane|||Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.|||Membrane http://togogenome.org/gene/31033:cnep1r1 ^@ http://purl.uniprot.org/uniprot/A0A674MFC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNEP1R1 family.|||Cytoplasm|||Membrane|||Nucleus membrane http://togogenome.org/gene/31033:skap2 ^@ http://purl.uniprot.org/uniprot/Q1KKZ1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SKAP family.|||Cytoplasm|||May be involved in B-cell and macrophage adhesion processes. May play a role in src signaling pathway (By similarity).|||Phosphorylated on tyrosines. http://togogenome.org/gene/31033:dstyk ^@ http://purl.uniprot.org/uniprot/Q4VSN2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.|||Cell junction|||Cell membrane|||Cytoplasm|||May act as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death. May play a role in the embryonic development. http://togogenome.org/gene/31033:mri1 ^@ http://purl.uniprot.org/uniprot/H2TSE3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:lgr6 ^@ http://purl.uniprot.org/uniprot/H2TVE7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101064414 ^@ http://purl.uniprot.org/uniprot/A0A674N1P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/31033:pik3ca ^@ http://purl.uniprot.org/uniprot/H2SAV2 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/31033:LOC101069382 ^@ http://purl.uniprot.org/uniprot/H2TYP1 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/31033:pdpk1 ^@ http://purl.uniprot.org/uniprot/H2USE9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. http://togogenome.org/gene/31033:hhat ^@ http://purl.uniprot.org/uniprot/A0A674NTM8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:galnt2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KG46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:tsnare1 ^@ http://purl.uniprot.org/uniprot/H2UWA7 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/31033:LOC101079404 ^@ http://purl.uniprot.org/uniprot/H2S926 ^@ Similarity ^@ Belongs to the DSD1 family. http://togogenome.org/gene/31033:rps24 ^@ http://purl.uniprot.org/uniprot/H2SW49 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/31033:LOC101063381 ^@ http://purl.uniprot.org/uniprot/H2TX50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:s1pr1 ^@ http://purl.uniprot.org/uniprot/H2TJ49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101068302 ^@ http://purl.uniprot.org/uniprot/A0A3B5K545 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/31033:atp6v1e1 ^@ http://purl.uniprot.org/uniprot/H2S2M4 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/31033:manbal ^@ http://purl.uniprot.org/uniprot/H2VCQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0239 family.|||Membrane http://togogenome.org/gene/31033:atp9a ^@ http://purl.uniprot.org/uniprot/H2SV78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/31033:dlx2 ^@ http://purl.uniprot.org/uniprot/H2V8C6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101065188 ^@ http://purl.uniprot.org/uniprot/A0A674MJ21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CART family.|||Secreted http://togogenome.org/gene/31033:LOC101076808 ^@ http://purl.uniprot.org/uniprot/A0A674PRU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:LOC101065464 ^@ http://purl.uniprot.org/uniprot/H2VB22 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101061715 ^@ http://purl.uniprot.org/uniprot/H2VF25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/31033:LOC101072272 ^@ http://purl.uniprot.org/uniprot/H2RXC6 ^@ Similarity ^@ Belongs to the PDCD4 family. http://togogenome.org/gene/31033:dcaf11 ^@ http://purl.uniprot.org/uniprot/A0A3B5KLL0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the WD repeat LEC14B family.|||Interacts with DDB1 and CUL4A.|||May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. http://togogenome.org/gene/31033:LOC101072655 ^@ http://purl.uniprot.org/uniprot/A0A674NYZ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.|||Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.|||cytoskeleton http://togogenome.org/gene/31033:LOC101073863 ^@ http://purl.uniprot.org/uniprot/A0A3B5KPW6 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/31033:sdhaf4 ^@ http://purl.uniprot.org/uniprot/A0A674NLQ7 ^@ Similarity ^@ Belongs to the SDHAF4 family. http://togogenome.org/gene/31033:pgls ^@ http://purl.uniprot.org/uniprot/H2UJ91 ^@ Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.|||Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. http://togogenome.org/gene/31033:trpv2 ^@ http://purl.uniprot.org/uniprot/H2RNL5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:ncbp1 ^@ http://purl.uniprot.org/uniprot/H2SJV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NCBP1 family.|||Nucleus http://togogenome.org/gene/31033:LOC101077253 ^@ http://purl.uniprot.org/uniprot/H2V5I3 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/31033:wnt2 ^@ http://purl.uniprot.org/uniprot/Q8UW39 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/31033:slc35b3 ^@ http://purl.uniprot.org/uniprot/A0A3B5JWU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/31033:gucy1a1 ^@ http://purl.uniprot.org/uniprot/Q90VV5 ^@ Similarity ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. http://togogenome.org/gene/31033:smco4 ^@ http://purl.uniprot.org/uniprot/Q9I859 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMCO4 family.|||Membrane http://togogenome.org/gene/31033:LOC101067333 ^@ http://purl.uniprot.org/uniprot/Q1KL06 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme c group covalently per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).|||Mitochondrion intermembrane space http://togogenome.org/gene/31033:LOC101063305 ^@ http://purl.uniprot.org/uniprot/P61207 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/31033:LOC101066813 ^@ http://purl.uniprot.org/uniprot/A0A674N2X2 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/31033:LOC101071673 ^@ http://purl.uniprot.org/uniprot/A0A674P2R2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/31033:LOC105416773 ^@ http://purl.uniprot.org/uniprot/A0A674MQT3|||http://purl.uniprot.org/uniprot/A0A674P428 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/31033:LOC101079261 ^@ http://purl.uniprot.org/uniprot/H2SBQ4 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/31033:LOC101077681 ^@ http://purl.uniprot.org/uniprot/H2S7R5 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/31033:LOC101065677 ^@ http://purl.uniprot.org/uniprot/H2UTT3 ^@ Similarity ^@ Belongs to the LSM14 family. http://togogenome.org/gene/31033:med27 ^@ http://purl.uniprot.org/uniprot/H2VBW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 27 family.|||Nucleus http://togogenome.org/gene/31033:tbl1xr1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K5P0 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/31033:LOC777975 ^@ http://purl.uniprot.org/uniprot/Q2NNA8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the noggin family.|||Homodimer.|||Secreted http://togogenome.org/gene/31033:LOC101069301 ^@ http://purl.uniprot.org/uniprot/H2SAY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/31033:LOC101064935 ^@ http://purl.uniprot.org/uniprot/A0A3B5KAJ6 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/31033:ppp5c ^@ http://purl.uniprot.org/uniprot/A0A3B5JXP2 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. http://togogenome.org/gene/31033:LOC101064702 ^@ http://purl.uniprot.org/uniprot/A0A3B5JUC2 ^@ Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. http://togogenome.org/gene/31033:LOC101063464 ^@ http://purl.uniprot.org/uniprot/A0A674PNR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Musashi family.|||Cytoplasm http://togogenome.org/gene/31033:igfbp3 ^@ http://purl.uniprot.org/uniprot/H2U8K6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/31033:lcat ^@ http://purl.uniprot.org/uniprot/A0A674PAM7 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/31033:LOC101072944 ^@ http://purl.uniprot.org/uniprot/A0A674NNM4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tweety family.|||Cell membrane|||Membrane|||Probable chloride channel. http://togogenome.org/gene/31033:foxf1 ^@ http://purl.uniprot.org/uniprot/A0A674NVF1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:slc35b4 ^@ http://purl.uniprot.org/uniprot/A0A3B5K1Q1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/31033:cog6 ^@ http://purl.uniprot.org/uniprot/A0A674MMH9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COG6 family.|||Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.|||Golgi apparatus membrane|||Membrane|||Required for normal Golgi function. http://togogenome.org/gene/31033:smpd2 ^@ http://purl.uniprot.org/uniprot/A0A674PJ17 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/31033:kras ^@ http://purl.uniprot.org/uniprot/A0A3B5KHK5|||http://purl.uniprot.org/uniprot/A0A674N4I3 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/31033:LOC101073244 ^@ http://purl.uniprot.org/uniprot/A0A674NRC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:seh1l ^@ http://purl.uniprot.org/uniprot/A0A674NJ21 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.|||Lysosome membrane|||kinetochore http://togogenome.org/gene/31033:desi1 ^@ http://purl.uniprot.org/uniprot/A0A674NYF0 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/31033:cldn28a ^@ http://purl.uniprot.org/uniprot/Q6E5Q4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:polr2g ^@ http://purl.uniprot.org/uniprot/A0A3B5K0Y3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/31033:LOC101065096 ^@ http://purl.uniprot.org/uniprot/A0A3B5KAK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/31033:mitf ^@ http://purl.uniprot.org/uniprot/A0A674MP27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/31033:LOC101076478 ^@ http://purl.uniprot.org/uniprot/P79748 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction (By similarity). http://togogenome.org/gene/31033:lamtor5 ^@ http://purl.uniprot.org/uniprot/A0A3B5K419 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR5 family.|||Lysosome http://togogenome.org/gene/31033:LOC101074738 ^@ http://purl.uniprot.org/uniprot/H2TKJ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101070302 ^@ http://purl.uniprot.org/uniprot/H2S7P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:cul9 ^@ http://purl.uniprot.org/uniprot/A0A674P133 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cullin family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101074708 ^@ http://purl.uniprot.org/uniprot/H2T4Y1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/31033:traf2 ^@ http://purl.uniprot.org/uniprot/H2VF06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/31033:slc25a35 ^@ http://purl.uniprot.org/uniprot/A0A3B5KI09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:LOC101078984 ^@ http://purl.uniprot.org/uniprot/A0A3B5KMQ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/31033:LOC101068466 ^@ http://purl.uniprot.org/uniprot/A0A674PKJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:nsg2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KJN1 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/31033:LOC101068554 ^@ http://purl.uniprot.org/uniprot/H2RWI6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24 family. SPT16 subfamily.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Component of the FACT complex.|||Nucleus http://togogenome.org/gene/31033:LOC101071626 ^@ http://purl.uniprot.org/uniprot/H2RSZ8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/31033:LOC101076887 ^@ http://purl.uniprot.org/uniprot/H2SXG7 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/31033:LOC101073063 ^@ http://purl.uniprot.org/uniprot/H2TF55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/31033:rapgef2 ^@ http://purl.uniprot.org/uniprot/A0A674MWT7 ^@ Similarity ^@ Belongs to the RAPGEF2 family. http://togogenome.org/gene/31033:ccnf ^@ http://purl.uniprot.org/uniprot/A0A674P319 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.|||Nucleus|||centriole|||perinuclear region http://togogenome.org/gene/31033:dars ^@ http://purl.uniprot.org/uniprot/A0A674NKB2 ^@ Function|||Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. http://togogenome.org/gene/31033:LOC101068543 ^@ http://purl.uniprot.org/uniprot/H2SK65 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:smim15 ^@ http://purl.uniprot.org/uniprot/H2UFJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM15 family.|||Membrane http://togogenome.org/gene/31033:LOC101078557 ^@ http://purl.uniprot.org/uniprot/H2TIU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/31033:LOC101068470 ^@ http://purl.uniprot.org/uniprot/H2UT54 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/31033:gdf11 ^@ http://purl.uniprot.org/uniprot/H2VDF5 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/31033:mrps17 ^@ http://purl.uniprot.org/uniprot/A0A3B5JYB6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/31033:ctsd ^@ http://purl.uniprot.org/uniprot/Q5TLU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Lysosome http://togogenome.org/gene/31033:gnptab ^@ http://purl.uniprot.org/uniprot/H2U168 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the stealth family.|||Membrane http://togogenome.org/gene/31033:nudt2 ^@ http://purl.uniprot.org/uniprot/H2UNY4 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/31033:cldn8d ^@ http://purl.uniprot.org/uniprot/Q6E5P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/31033:dhrs7 ^@ http://purl.uniprot.org/uniprot/H2TN82 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/31033:LOC101065046 ^@ http://purl.uniprot.org/uniprot/H2TWL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101067496 ^@ http://purl.uniprot.org/uniprot/H2RJL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. http://togogenome.org/gene/31033:rhcg ^@ http://purl.uniprot.org/uniprot/Q18PF5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Apical cell membrane|||Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.|||Homotrimer.|||Specifically expressed in the gill by mitochondria-rich cells. http://togogenome.org/gene/31033:slc20a2 ^@ http://purl.uniprot.org/uniprot/H2V0J3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/31033:mtx2 ^@ http://purl.uniprot.org/uniprot/Q1KKR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/31033:fer ^@ http://purl.uniprot.org/uniprot/H2TE37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.|||cytoskeleton http://togogenome.org/gene/31033:cdk20 ^@ http://purl.uniprot.org/uniprot/A0A674MRU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||cilium http://togogenome.org/gene/31033:KEF89_p03 ^@ http://purl.uniprot.org/uniprot/Q8HCV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 5 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/31033:LOC101072878 ^@ http://purl.uniprot.org/uniprot/A0A674MPH3 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/31033:aoc1 ^@ http://purl.uniprot.org/uniprot/H2V9H0 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/31033:myog ^@ http://purl.uniprot.org/uniprot/H2RRN6 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/31033:LOC101076270 ^@ http://purl.uniprot.org/uniprot/A0A674N920 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:xk ^@ http://purl.uniprot.org/uniprot/Q5GH53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/31033:olfm1 ^@ http://purl.uniprot.org/uniprot/A0A674MJR7|||http://purl.uniprot.org/uniprot/H2VEA2 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/31033:tmem178a ^@ http://purl.uniprot.org/uniprot/H2TVP5 ^@ Similarity ^@ Belongs to the TMEM178 family. http://togogenome.org/gene/31033:zdhhc24 ^@ http://purl.uniprot.org/uniprot/A0A3B5KGM7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/31033:tnfa ^@ http://purl.uniprot.org/uniprot/Q4W8A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tumor necrosis factor family.|||Membrane http://togogenome.org/gene/31033:LOC101064948 ^@ http://purl.uniprot.org/uniprot/H2SKN0 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Vesicle http://togogenome.org/gene/31033:mbnl2a ^@ http://purl.uniprot.org/uniprot/Q6Q2B2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the muscleblind family.|||Cytoplasm|||Expressed in fast and slow myotomal muscle, heart, liver, skin, brain and testis.|||Involved in pre-mRNA alternative splicing regulation. RNA-binding protein that binds to 5'ACACCC-3' core sequence (By similarity).|||Nucleus http://togogenome.org/gene/31033:slc2a2 ^@ http://purl.uniprot.org/uniprot/A0A674PK33 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/31033:pfdn6 ^@ http://purl.uniprot.org/uniprot/H2SAQ1 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/31033:pkn1 ^@ http://purl.uniprot.org/uniprot/H2S713|||http://purl.uniprot.org/uniprot/H2S715 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Nucleus http://togogenome.org/gene/31033:LOC101070349 ^@ http://purl.uniprot.org/uniprot/A0A674PEW8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:LOC101065972 ^@ http://purl.uniprot.org/uniprot/A0A3B5KBY7 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/31033:sec11a ^@ http://purl.uniprot.org/uniprot/H2SEF0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:pdx1 ^@ http://purl.uniprot.org/uniprot/H2SN16 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:hcrtr2 ^@ http://purl.uniprot.org/uniprot/H2UQF0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:gcg ^@ http://purl.uniprot.org/uniprot/H2SF28 ^@ Similarity ^@ Belongs to the glucagon family. http://togogenome.org/gene/31033:LOC101078933 ^@ http://purl.uniprot.org/uniprot/H2T3T0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101078409 ^@ http://purl.uniprot.org/uniprot/H2TCD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAM50/omp85 family.|||Mitochondrion outer membrane http://togogenome.org/gene/31033:slc30a9 ^@ http://purl.uniprot.org/uniprot/H2UGY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Endoplasmic reticulum|||Membrane|||Mitochondrion membrane|||Nucleus http://togogenome.org/gene/31033:LOC101069572 ^@ http://purl.uniprot.org/uniprot/H2SWT0 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/31033:igf2 ^@ http://purl.uniprot.org/uniprot/A0JGX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/31033:fli1 ^@ http://purl.uniprot.org/uniprot/H2T346 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/31033:adcyap1 ^@ http://purl.uniprot.org/uniprot/A8DPE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/31033:ttyh3 ^@ http://purl.uniprot.org/uniprot/H2UFB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tweety family.|||Cell membrane|||Membrane|||Probable chloride channel. http://togogenome.org/gene/31033:LOC101079686 ^@ http://purl.uniprot.org/uniprot/A0A3B5JXQ9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:ppard ^@ http://purl.uniprot.org/uniprot/A4PE13|||http://purl.uniprot.org/uniprot/H2UWE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/31033:LOC101070473 ^@ http://purl.uniprot.org/uniprot/H2UHI6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101073693 ^@ http://purl.uniprot.org/uniprot/H2URJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/31033:tsfm ^@ http://purl.uniprot.org/uniprot/H2S473 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Mitochondrion http://togogenome.org/gene/31033:chst10 ^@ http://purl.uniprot.org/uniprot/H2SZP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:spock3 ^@ http://purl.uniprot.org/uniprot/A0A674NXS1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:ccn4 ^@ http://purl.uniprot.org/uniprot/H2TQJ3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/31033:LOC101073052 ^@ http://purl.uniprot.org/uniprot/H2V4H5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/31033:calhm3 ^@ http://purl.uniprot.org/uniprot/H2RKV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/31033:rbm48 ^@ http://purl.uniprot.org/uniprot/H2U2D5 ^@ Function|||Similarity ^@ As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.|||Belongs to the RBM48 family. http://togogenome.org/gene/31033:igfbp2 ^@ http://purl.uniprot.org/uniprot/H2UDH6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/31033:LOC613235 ^@ http://purl.uniprot.org/uniprot/Q3SCC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/31033:fabp7 ^@ http://purl.uniprot.org/uniprot/H2TV98 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/31033:LOC101067323 ^@ http://purl.uniprot.org/uniprot/H2UK75 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/31033:LOC101073198 ^@ http://purl.uniprot.org/uniprot/A0A674NZL5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:lcor ^@ http://purl.uniprot.org/uniprot/H2SRP1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:rspo3 ^@ http://purl.uniprot.org/uniprot/A0A674NDD3|||http://purl.uniprot.org/uniprot/H2S9X6 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/31033:LOC101077642 ^@ http://purl.uniprot.org/uniprot/H2SEN1 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/31033:LOC101072411 ^@ http://purl.uniprot.org/uniprot/H2SJG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:ak3 ^@ http://purl.uniprot.org/uniprot/H2TQ17 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK3 subfamily.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.|||Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.|||Mitochondrion matrix|||Monomer. http://togogenome.org/gene/31033:os9 ^@ http://purl.uniprot.org/uniprot/A0A674NRF2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OS-9 family.|||Endoplasmic reticulum lumen|||Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation. http://togogenome.org/gene/31033:LOC101072814 ^@ http://purl.uniprot.org/uniprot/A0A674PA35 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:LOC101073679 ^@ http://purl.uniprot.org/uniprot/A0A3B5KN04 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:LOC101067344 ^@ http://purl.uniprot.org/uniprot/A0A674MJU1 ^@ Similarity ^@ Belongs to the pellino family. http://togogenome.org/gene/31033:LOC101076958 ^@ http://purl.uniprot.org/uniprot/A0A674PDY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/31033:LOC101075023 ^@ http://purl.uniprot.org/uniprot/A0A3B5KD08 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/31033:rp2 ^@ http://purl.uniprot.org/uniprot/H2TSJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.|||Belongs to the TBCC family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:slc25a34 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:vps26b ^@ http://purl.uniprot.org/uniprot/A0A674P1R0 ^@ Similarity ^@ Belongs to the VPS26 family. http://togogenome.org/gene/31033:dmrt3 ^@ http://purl.uniprot.org/uniprot/Q90WM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus|||Probable transcription factor that plays a role in configuring the spinal circuits controlling motion in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling movements. May regulate transcription (By similarity). http://togogenome.org/gene/31033:mcts1 ^@ http://purl.uniprot.org/uniprot/H2TI11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCTS1 family.|||Cytoplasm http://togogenome.org/gene/31033:lmnb2 ^@ http://purl.uniprot.org/uniprot/H2SCX9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/31033:LOC101071476 ^@ http://purl.uniprot.org/uniprot/H2S7A9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/31033:elac1 ^@ http://purl.uniprot.org/uniprot/H2U8I3 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/31033:npb ^@ http://purl.uniprot.org/uniprot/H2TX89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the neuropeptide B/W family.|||Secreted http://togogenome.org/gene/31033:inpp5a ^@ http://purl.uniprot.org/uniprot/H2THM1 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family. http://togogenome.org/gene/31033:LOC101070683 ^@ http://purl.uniprot.org/uniprot/A0A3B5K586 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101062348 ^@ http://purl.uniprot.org/uniprot/A0A3B5K8V4 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/31033:smarcd1 ^@ http://purl.uniprot.org/uniprot/H2VD12 ^@ Similarity ^@ Belongs to the SMARCD family. http://togogenome.org/gene/31033:uxs1 ^@ http://purl.uniprot.org/uniprot/A0A674NEX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/31033:sin3b ^@ http://purl.uniprot.org/uniprot/A0A674PDW3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101077835 ^@ http://purl.uniprot.org/uniprot/A0A674MR02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/31033:sparc ^@ http://purl.uniprot.org/uniprot/Q6PVV7 ^@ Similarity ^@ Belongs to the SPARC family. http://togogenome.org/gene/31033:foxn2 ^@ http://purl.uniprot.org/uniprot/H2UDM3 ^@ Function|||Subcellular Location Annotation ^@ Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).|||Nucleus http://togogenome.org/gene/31033:LOC101078705 ^@ http://purl.uniprot.org/uniprot/H2TND0 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:dgat1 ^@ http://purl.uniprot.org/uniprot/H2U4I6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Homodimer or homotetramer; both forms have similar enzymatic activities.|||Membrane http://togogenome.org/gene/31033:klc2 ^@ http://purl.uniprot.org/uniprot/H2SVZ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/31033:LOC101071239 ^@ http://purl.uniprot.org/uniprot/H2V0L3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/31033:LOC101066478 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZM5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:anapc13 ^@ http://purl.uniprot.org/uniprot/A0A3B5K040 ^@ Function|||Similarity ^@ Belongs to the APC13 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. http://togogenome.org/gene/31033:LOC101079307 ^@ http://purl.uniprot.org/uniprot/H2V8U4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/31033:LOC101071993 ^@ http://purl.uniprot.org/uniprot/H2SMW3 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family. http://togogenome.org/gene/31033:nil1fm ^@ http://purl.uniprot.org/uniprot/A0A3B5JXV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/31033:rps11 ^@ http://purl.uniprot.org/uniprot/H2UH24 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/31033:pfcyp19b-tstr ^@ http://purl.uniprot.org/uniprot/D2KTU7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/31033:LOC101074042 ^@ http://purl.uniprot.org/uniprot/H2UA06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:uba3 ^@ http://purl.uniprot.org/uniprot/H2U2Y1 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.|||Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. http://togogenome.org/gene/31033:LOC101076884 ^@ http://purl.uniprot.org/uniprot/H2RUY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:elp4 ^@ http://purl.uniprot.org/uniprot/H2SZ22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP4 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:LOC101072328 ^@ http://purl.uniprot.org/uniprot/A0A674N168 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/31033:rnf114 ^@ http://purl.uniprot.org/uniprot/A0A3B5K4L3 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.|||Nucleus http://togogenome.org/gene/31033:LOC101067916 ^@ http://purl.uniprot.org/uniprot/H2T4W3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/31033:LOC101073228 ^@ http://purl.uniprot.org/uniprot/H2RVL8 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/31033:LOC101071804 ^@ http://purl.uniprot.org/uniprot/H2TV99 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/31033:LOC101064253 ^@ http://purl.uniprot.org/uniprot/Q1KL13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Deformed subfamily.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101075419 ^@ http://purl.uniprot.org/uniprot/H2SXX9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101074778 ^@ http://purl.uniprot.org/uniprot/H2T307 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101064782 ^@ http://purl.uniprot.org/uniprot/H2U4P2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Clp1 family. Clp1 subfamily.|||Component of the tRNA splicing endonuclease complex. Component of pre-mRNA cleavage complex II (CF-II).|||Nucleus|||Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing. http://togogenome.org/gene/31033:rbp1 ^@ http://purl.uniprot.org/uniprot/H2RL96 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/31033:slc8b1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KDP7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:tas1r2 ^@ http://purl.uniprot.org/uniprot/Q2MHK1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101075029 ^@ http://purl.uniprot.org/uniprot/H2S886 ^@ Similarity ^@ Belongs to the TBP family. http://togogenome.org/gene/31033:fut9b ^@ http://purl.uniprot.org/uniprot/Q70AH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/31033:syndig1l ^@ http://purl.uniprot.org/uniprot/H2UQ20 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/31033:tmem205 ^@ http://purl.uniprot.org/uniprot/A0A3B5KSE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM205 family.|||Membrane http://togogenome.org/gene/31033:slc25a5 ^@ http://purl.uniprot.org/uniprot/Q5KSP2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/31033:LOC101069239 ^@ http://purl.uniprot.org/uniprot/A0A674PIC3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Cytoplasm|||LSm subunits form a heteromer with a donut shape.|||P-body|||Probably involved with other LSm subunits in the general process of degradation of mRNAs. http://togogenome.org/gene/31033:tmem115 ^@ http://purl.uniprot.org/uniprot/A0A674MWA3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101076248 ^@ http://purl.uniprot.org/uniprot/H2UDS7 ^@ Similarity ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. http://togogenome.org/gene/31033:LOC101066824 ^@ http://purl.uniprot.org/uniprot/A0A674P714 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:fat-5 ^@ http://purl.uniprot.org/uniprot/Q5XQ38 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/31033:LOC101077630 ^@ http://purl.uniprot.org/uniprot/H2UCZ6 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/31033:smc2 ^@ http://purl.uniprot.org/uniprot/Q802S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC2 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/31033:LOC101080234 ^@ http://purl.uniprot.org/uniprot/A0A674NY87 ^@ Similarity ^@ Belongs to the DDA1 family. http://togogenome.org/gene/31033:LOC101077481 ^@ http://purl.uniprot.org/uniprot/A0A674P807 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/31033:LOC101079075 ^@ http://purl.uniprot.org/uniprot/A0A674NZR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101063840 ^@ http://purl.uniprot.org/uniprot/A0A3B5KH35 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/31033:lage3 ^@ http://purl.uniprot.org/uniprot/A0A674MQW7 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/31033:LOC777991 ^@ http://purl.uniprot.org/uniprot/H2SH46 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/31033:itgb6 ^@ http://purl.uniprot.org/uniprot/H2V421 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:apex1 ^@ http://purl.uniprot.org/uniprot/H2SCJ4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/31033:bbs5 ^@ http://purl.uniprot.org/uniprot/H2V9K1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BBS5 family.|||Membrane|||Required for ciliogenesis.|||centriolar satellite|||cilium membrane http://togogenome.org/gene/31033:plxna3 ^@ http://purl.uniprot.org/uniprot/H2U7P1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:asic1 ^@ http://purl.uniprot.org/uniprot/A0A674MRE7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101074288 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZ98 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity.|||Membrane http://togogenome.org/gene/31033:LOC101071843 ^@ http://purl.uniprot.org/uniprot/H2SDA8 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/31033:hint3 ^@ http://purl.uniprot.org/uniprot/A0A674P9P5 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/31033:LOC101074575 ^@ http://purl.uniprot.org/uniprot/A0A674NQ88 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/31033:LOC101063424 ^@ http://purl.uniprot.org/uniprot/H2V5J8 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/31033:dvl2 ^@ http://purl.uniprot.org/uniprot/H2UCB6 ^@ Similarity ^@ Belongs to the DSH family. http://togogenome.org/gene/31033:c20h1orf52 ^@ http://purl.uniprot.org/uniprot/H2VDE1 ^@ Similarity ^@ Belongs to the UPF0690 family. http://togogenome.org/gene/31033:LOC101076480 ^@ http://purl.uniprot.org/uniprot/S0BBV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/31033:LOC101069505 ^@ http://purl.uniprot.org/uniprot/H2SEM5 ^@ Caution|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.|||Belongs to the universal ribosomal protein uS2 family.|||Cell membrane|||Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK.|||Nucleus|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis.|||This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. http://togogenome.org/gene/31033:adra1b ^@ http://purl.uniprot.org/uniprot/H2RQJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Membrane|||This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.|||caveola http://togogenome.org/gene/31033:vps36 ^@ http://purl.uniprot.org/uniprot/A0A3B5KFY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS36 family.|||Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II).|||Cytoplasm|||Endosome http://togogenome.org/gene/31033:LOC101069312 ^@ http://purl.uniprot.org/uniprot/H2UN25 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:panx2 ^@ http://purl.uniprot.org/uniprot/A0A3B5K011 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/31033:exosc1 ^@ http://purl.uniprot.org/uniprot/H2T3A0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:slc41a1 ^@ http://purl.uniprot.org/uniprot/A0A6D2Y5J7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/31033:ing3 ^@ http://purl.uniprot.org/uniprot/A0A3B5KM17 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/31033:LOC101078646 ^@ http://purl.uniprot.org/uniprot/H2SBL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/31033:LOC101062066 ^@ http://purl.uniprot.org/uniprot/A0A674PKI8 ^@ Similarity|||Subunit ^@ Belongs to the CutA family.|||Homotrimer. http://togogenome.org/gene/31033:bmp15 ^@ http://purl.uniprot.org/uniprot/A0A3B5K3Z6 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/31033:LOC101067570 ^@ http://purl.uniprot.org/uniprot/H2SGT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 16 (GT16) protein family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:naga ^@ http://purl.uniprot.org/uniprot/H2UQ40 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/31033:LOC101067225 ^@ http://purl.uniprot.org/uniprot/A0A3B5KE37 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/31033:specc1l ^@ http://purl.uniprot.org/uniprot/Q2KN94 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytospin-A family.|||Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity).|||May interact with both microtubules and actin cytoskeleton.|||cytoskeleton|||gap junction|||spindle http://togogenome.org/gene/31033:LOC101066291 ^@ http://purl.uniprot.org/uniprot/A0A674MJD6 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/31033:LOC101062063 ^@ http://purl.uniprot.org/uniprot/H2SC19 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 zinc ion per subunit.|||Homotetramer.|||Involved in the regulation of homocysteine metabolism. http://togogenome.org/gene/31033:cacna2d1 ^@ http://purl.uniprot.org/uniprot/H2UCV4 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/31033:LOC101077910 ^@ http://purl.uniprot.org/uniprot/H2S7R5 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/31033:rab3ip ^@ http://purl.uniprot.org/uniprot/H2SYK3 ^@ Similarity ^@ Belongs to the SEC2 family. http://togogenome.org/gene/31033:nsun6 ^@ http://purl.uniprot.org/uniprot/H2T814 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/31033:hbegf ^@ http://purl.uniprot.org/uniprot/A0A3B5K1I4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101064704 ^@ http://purl.uniprot.org/uniprot/H2V4T3 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/31033:LOC101070083 ^@ http://purl.uniprot.org/uniprot/H2SDU8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family.|||Homotrimer.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/31033:sh2b2 ^@ http://purl.uniprot.org/uniprot/H2T7N9 ^@ Similarity ^@ Belongs to the SH2B adapter family. http://togogenome.org/gene/31033:tdo2 ^@ http://purl.uniprot.org/uniprot/H2UT80 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the tryptophan 2,3-dioxygenase family.|||Binds 1 heme group per subunit.|||Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.|||Homotetramer. Dimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101079998 ^@ http://purl.uniprot.org/uniprot/A0A3B5K891 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101067801 ^@ http://purl.uniprot.org/uniprot/H2UZ87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/31033:rbks ^@ http://purl.uniprot.org/uniprot/H2SRH7 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Nucleus|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/31033:LOC101065871 ^@ http://purl.uniprot.org/uniprot/Q802A2 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/31033:LOC101074197 ^@ http://purl.uniprot.org/uniprot/A0A674MRB8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/31033:LOC101062196 ^@ http://purl.uniprot.org/uniprot/H2TV10 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/31033:trf3 ^@ http://purl.uniprot.org/uniprot/Q6SJ94 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus|||TATA box-binding transcription factor. Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis (By similarity). http://togogenome.org/gene/31033:timp2 ^@ http://purl.uniprot.org/uniprot/Q4JF85 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/31033:tm7sf2 ^@ http://purl.uniprot.org/uniprot/A0A674NRC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/31033:il-20 ^@ http://purl.uniprot.org/uniprot/Q2PDG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/31033:pou2f1 ^@ http://purl.uniprot.org/uniprot/A0A674PH32 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-2 subfamily.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:cdk5rap1 ^@ http://purl.uniprot.org/uniprot/A0A674P510 ^@ Similarity ^@ Belongs to the methylthiotransferase family. MiaB subfamily. http://togogenome.org/gene/31033:rnf7 ^@ http://purl.uniprot.org/uniprot/H2SUJ8 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/31033:LOC101077524 ^@ http://purl.uniprot.org/uniprot/H2SHF1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFIIE beta subunit family.|||Nucleus|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.|||Tetramer of two alpha and two beta chains. http://togogenome.org/gene/31033:gamt ^@ http://purl.uniprot.org/uniprot/A0A3B5K6S0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.|||Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor.|||Monomer. http://togogenome.org/gene/31033:LOC105416819 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZ60 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101066562 ^@ http://purl.uniprot.org/uniprot/A0A674MMQ5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:f2 ^@ http://purl.uniprot.org/uniprot/Q804W7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.|||extracellular space http://togogenome.org/gene/31033:LOC101070080 ^@ http://purl.uniprot.org/uniprot/A0A3B5KRA3 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/31033:naxe ^@ http://purl.uniprot.org/uniprot/H2U9Q0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NnrE/AIBP family.|||Binds 1 potassium ion per subunit.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion|||Secreted http://togogenome.org/gene/31033:pex3 ^@ http://purl.uniprot.org/uniprot/H2UUY8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with PEX19.|||Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.|||Peroxisome membrane http://togogenome.org/gene/31033:LOC101063190 ^@ http://purl.uniprot.org/uniprot/H2TX46 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homo- and heterotetramers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:gtpbp10 ^@ http://purl.uniprot.org/uniprot/A0A3B5KKJ9 ^@ Similarity ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. http://togogenome.org/gene/31033:LOC101077937 ^@ http://purl.uniprot.org/uniprot/H2V2P9 ^@ Subcellular Location Annotation ^@ Membrane|||dendrite http://togogenome.org/gene/31033:LOC101074115 ^@ http://purl.uniprot.org/uniprot/H2VES7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/31033:nop53 ^@ http://purl.uniprot.org/uniprot/H2SHE3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP53 family.|||May play a role in ribosome biogenesis.|||nucleolus|||nucleoplasm http://togogenome.org/gene/31033:LOC101077877 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM88 family.|||Membrane http://togogenome.org/gene/31033:rprd1b ^@ http://purl.uniprot.org/uniprot/A0A3B5KHG1|||http://purl.uniprot.org/uniprot/H2UTG3 ^@ Similarity ^@ Belongs to the UPF0400 (RTT103) family. http://togogenome.org/gene/31033:coq10b ^@ http://purl.uniprot.org/uniprot/H2USC0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/31033:apoA-IV4 ^@ http://purl.uniprot.org/uniprot/Q5KSU1 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/31033:ddx46 ^@ http://purl.uniprot.org/uniprot/H2TCC6 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/31033:dok6 ^@ http://purl.uniprot.org/uniprot/H2SGD0 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/31033:hs6st3 ^@ http://purl.uniprot.org/uniprot/H2RY20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/31033:gabrg2 ^@ http://purl.uniprot.org/uniprot/A0A674N4Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/31033:apoe2 ^@ http://purl.uniprot.org/uniprot/Q5KST8 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/31033:ddrgk1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K6A1 ^@ Similarity ^@ Belongs to the DDRGK1 family. http://togogenome.org/gene/31033:ppp1r14c ^@ http://purl.uniprot.org/uniprot/A0A3B5K7H1 ^@ Similarity ^@ Belongs to the PP1 inhibitor family. http://togogenome.org/gene/31033:mrpl40 ^@ http://purl.uniprot.org/uniprot/A0A3B5JY34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL40 family.|||Mitochondrion http://togogenome.org/gene/31033:ipo5 ^@ http://purl.uniprot.org/uniprot/H2T0S9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/31033:tspan3 ^@ http://purl.uniprot.org/uniprot/H2T5L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/31033:LOC101071548 ^@ http://purl.uniprot.org/uniprot/A0A3B5K557 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101061541 ^@ http://purl.uniprot.org/uniprot/A0A674NN63 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/31033:il1rapl1 ^@ http://purl.uniprot.org/uniprot/A0A674N1J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the interleukin-1 receptor family.|||Membrane http://togogenome.org/gene/31033:prc1 ^@ http://purl.uniprot.org/uniprot/A0A674MQ80 ^@ Similarity ^@ Belongs to the MAP65/ASE1 family. http://togogenome.org/gene/31033:LOC101072459 ^@ http://purl.uniprot.org/uniprot/H2TEH1|||http://purl.uniprot.org/uniprot/H2TEH2|||http://purl.uniprot.org/uniprot/H2TEH3 ^@ Function|||Subcellular Location Annotation ^@ Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.|||Membrane|||cytoskeleton|||filopodium|||ruffle http://togogenome.org/gene/31033:tmem192 ^@ http://purl.uniprot.org/uniprot/H2UQM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM192 family.|||Late endosome|||Lysosome membrane|||Membrane http://togogenome.org/gene/31033:dlk1 ^@ http://purl.uniprot.org/uniprot/H2TEW9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101069036 ^@ http://purl.uniprot.org/uniprot/H2V7U9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:pcdhac2 ^@ http://purl.uniprot.org/uniprot/A4KCG4 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/31033:LOC105417099 ^@ http://purl.uniprot.org/uniprot/A0A674NJ17 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/31033:emc8 ^@ http://purl.uniprot.org/uniprot/A0A674PC67 ^@ Similarity ^@ Belongs to the EMC8/EMC9 family. http://togogenome.org/gene/31033:pgpep1 ^@ http://purl.uniprot.org/uniprot/H2SNP8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C15 family.|||Cytoplasm|||Removes 5-oxoproline from various penultimate amino acid residues except L-proline. http://togogenome.org/gene/31033:gcnt3 ^@ http://purl.uniprot.org/uniprot/H2TX75 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:LOC101075531 ^@ http://purl.uniprot.org/uniprot/H2TQ24 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:drd2 ^@ http://purl.uniprot.org/uniprot/P53453 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Receptor for dopamine. http://togogenome.org/gene/31033:ants6 ^@ http://purl.uniprot.org/uniprot/Q5KSP4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/31033:mis18a ^@ http://purl.uniprot.org/uniprot/A0A674MEP0|||http://purl.uniprot.org/uniprot/A0A674MKS9 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.|||centromere http://togogenome.org/gene/31033:LOC101069214 ^@ http://purl.uniprot.org/uniprot/A0A674MGJ0 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/31033:LOC101072667 ^@ http://purl.uniprot.org/uniprot/A0A674MYX7 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/31033:LOC101064398 ^@ http://purl.uniprot.org/uniprot/A0A3B5K0G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/31033:naxd ^@ http://purl.uniprot.org/uniprot/H2TJQ1 ^@ Function|||Similarity ^@ Belongs to the NnrD/CARKD family.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. http://togogenome.org/gene/31033:ppie ^@ http://purl.uniprot.org/uniprot/Q8QGJ6 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.|||Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. http://togogenome.org/gene/31033:tcf7l2 ^@ http://purl.uniprot.org/uniprot/H2U4B6|||http://purl.uniprot.org/uniprot/H2U4B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/31033:tacr3 ^@ http://purl.uniprot.org/uniprot/A0A6D2X5R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:hspe1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K8B8 ^@ Similarity ^@ Belongs to the GroES chaperonin family. http://togogenome.org/gene/31033:LOC101061276 ^@ http://purl.uniprot.org/uniprot/A0A674ME96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/31033:lhpp ^@ http://purl.uniprot.org/uniprot/H2TK63 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/31033:nae1 ^@ http://purl.uniprot.org/uniprot/A0A674PQI3 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.|||Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. http://togogenome.org/gene/31033:s100z ^@ http://purl.uniprot.org/uniprot/A0A674PBZ5 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/31033:LOC101063622 ^@ http://purl.uniprot.org/uniprot/A0A674NMK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:gjc2 ^@ http://purl.uniprot.org/uniprot/A0A3B5K5E7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/31033:LOC101066150 ^@ http://purl.uniprot.org/uniprot/A0A3B5K7T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Membrane|||axon|||cytoskeleton|||synaptosome http://togogenome.org/gene/31033:LOC101066900 ^@ http://purl.uniprot.org/uniprot/H2TRA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARPC4 family.|||Cell projection|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.|||cytoskeleton http://togogenome.org/gene/31033:traf3 ^@ http://purl.uniprot.org/uniprot/H2SLR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101063201 ^@ http://purl.uniprot.org/uniprot/H2UX10 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:slc66a3 ^@ http://purl.uniprot.org/uniprot/H2TQU9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:rcl1 ^@ http://purl.uniprot.org/uniprot/A0A674PA99 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.|||Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.|||nucleolus http://togogenome.org/gene/31033:LOC101064878 ^@ http://purl.uniprot.org/uniprot/A0A3B5JX71 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily. http://togogenome.org/gene/31033:LOC101062786 ^@ http://purl.uniprot.org/uniprot/H2UQZ6|||http://purl.uniprot.org/uniprot/H2UQZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Cell membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/31033:bcdin3d ^@ http://purl.uniprot.org/uniprot/H2VCX5 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/31033:atp5mg ^@ http://purl.uniprot.org/uniprot/A0A674MIK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase g subunit family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion http://togogenome.org/gene/31033:gsx2 ^@ http://purl.uniprot.org/uniprot/H2UNF4 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:fdps ^@ http://purl.uniprot.org/uniprot/H2TTF5 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/31033:ddit4 ^@ http://purl.uniprot.org/uniprot/A0A674MVU3 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/31033:tapt1 ^@ http://purl.uniprot.org/uniprot/H2USE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAPT1 family.|||Membrane http://togogenome.org/gene/31033:map4k3 ^@ http://purl.uniprot.org/uniprot/A0A674MK70|||http://purl.uniprot.org/uniprot/A0A674NYG8 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. http://togogenome.org/gene/31033:rpl3 ^@ http://purl.uniprot.org/uniprot/A0A3B5KH25 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/31033:LOC101072717 ^@ http://purl.uniprot.org/uniprot/A0A674MSJ9 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/31033:spout1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K473 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. http://togogenome.org/gene/31033:LOC101080150 ^@ http://purl.uniprot.org/uniprot/A0A674MXC6 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/31033:LOC101068825 ^@ http://purl.uniprot.org/uniprot/H2TD56 ^@ Function|||Similarity|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Homodimer.|||It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.|||Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. http://togogenome.org/gene/31033:mmp23b ^@ http://purl.uniprot.org/uniprot/H2SQ54 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101067268 ^@ http://purl.uniprot.org/uniprot/A0A3B5KC02 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:pdlim3 ^@ http://purl.uniprot.org/uniprot/H2SMK8 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/31033:LOC101074783 ^@ http://purl.uniprot.org/uniprot/H2VEW0 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/31033:LOC101061626 ^@ http://purl.uniprot.org/uniprot/H2UPJ6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.|||Cytoplasm|||Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Nucleus|||nucleolus http://togogenome.org/gene/31033:adamts1 ^@ http://purl.uniprot.org/uniprot/H2TR39 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/31033:tmem184a ^@ http://purl.uniprot.org/uniprot/A0A3B5KMN6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:cldn30d ^@ http://purl.uniprot.org/uniprot/Q6E5R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/31033:LOC101062730 ^@ http://purl.uniprot.org/uniprot/H2TBN4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/31033:cdca7 ^@ http://purl.uniprot.org/uniprot/H2V7J1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/31033:LOC101065410 ^@ http://purl.uniprot.org/uniprot/H2UUX2 ^@ Similarity ^@ Belongs to the HARBI1 family. http://togogenome.org/gene/31033:fglce ^@ http://purl.uniprot.org/uniprot/Q2PED6 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:tada2a ^@ http://purl.uniprot.org/uniprot/A0A3B5K7W0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:oca2 ^@ http://purl.uniprot.org/uniprot/H2TDY4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:cldn29b ^@ http://purl.uniprot.org/uniprot/Q6E5R6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:pde8a ^@ http://purl.uniprot.org/uniprot/H2V3Q8 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/31033:trub2 ^@ http://purl.uniprot.org/uniprot/H2URS1 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/31033:crhbp ^@ http://purl.uniprot.org/uniprot/Q24JN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CRF-binding protein family.|||Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.|||Secreted http://togogenome.org/gene/31033:nipsnap2 ^@ http://purl.uniprot.org/uniprot/A0A674PG77 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/31033:LOC101074187 ^@ http://purl.uniprot.org/uniprot/H2UPM1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/31033:LOC101065330 ^@ http://purl.uniprot.org/uniprot/A0A674NSZ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked.|||Its primary function is the prevention of hypercalcemia. Upon release into the circulation, it lowers calcium transport by the gills, thereby reducing its rate of influx from the environment into the extracellular compartment. STC also stimulates phosphate reabsorption by renal proximal tubules. The consequence of this action is increased levels of plasma phosphate, which combines with excess calcium and promotes its disposal into bone and scales. http://togogenome.org/gene/31033:abr ^@ http://purl.uniprot.org/uniprot/H2RQR8 ^@ Subcellular Location Annotation ^@ Synapse|||axon|||dendritic spine http://togogenome.org/gene/31033:LOC101065890 ^@ http://purl.uniprot.org/uniprot/A0A674P9W4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:LOC101065009 ^@ http://purl.uniprot.org/uniprot/H2TGP1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:fez1 ^@ http://purl.uniprot.org/uniprot/H2SIU5 ^@ Similarity ^@ Belongs to the zygin family. http://togogenome.org/gene/31033:LOC101075267 ^@ http://purl.uniprot.org/uniprot/A0A3B5K4F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/31033:sf3a2 ^@ http://purl.uniprot.org/uniprot/H2TDJ6 ^@ Similarity ^@ Belongs to the SF3A2 family. http://togogenome.org/gene/31033:echs1 ^@ http://purl.uniprot.org/uniprot/H2UBV2 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/31033:actc1 ^@ http://purl.uniprot.org/uniprot/H2UI49 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/31033:LOC101061562 ^@ http://purl.uniprot.org/uniprot/H2TVI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/31033:LOC101067506 ^@ http://purl.uniprot.org/uniprot/A0A3B5KHD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/31033:e2f4 ^@ http://purl.uniprot.org/uniprot/H2TIK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/31033:arf1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KDL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/31033:map2k5 ^@ http://purl.uniprot.org/uniprot/H2V1U6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:LOC101078555 ^@ http://purl.uniprot.org/uniprot/H2UV65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cell surface|||Endosome|||Membrane http://togogenome.org/gene/31033:LOC101062215 ^@ http://purl.uniprot.org/uniprot/H2SNG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Secreted http://togogenome.org/gene/31033:stmn4 ^@ http://purl.uniprot.org/uniprot/H2RT81 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/31033:nectin1 ^@ http://purl.uniprot.org/uniprot/A0A674NCY8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101061223 ^@ http://purl.uniprot.org/uniprot/H2T1B7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tissue factor family.|||Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.|||Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. http://togogenome.org/gene/31033:irf2bp1 ^@ http://purl.uniprot.org/uniprot/H2RIR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF2BP family.|||Nucleus http://togogenome.org/gene/31033:LOC445940 ^@ http://purl.uniprot.org/uniprot/Q804X1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular space http://togogenome.org/gene/31033:LOC101069596 ^@ http://purl.uniprot.org/uniprot/A0A3B5KGV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/31033:rfrpr ^@ http://purl.uniprot.org/uniprot/Q05KN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/31033:LOC101074448 ^@ http://purl.uniprot.org/uniprot/H2RVW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/31033:ints7 ^@ http://purl.uniprot.org/uniprot/H2VA27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 7 family.|||Nucleus http://togogenome.org/gene/31033:brcc3 ^@ http://purl.uniprot.org/uniprot/H2S9G6 ^@ Similarity ^@ Belongs to the peptidase M67A family. BRCC36 subfamily. http://togogenome.org/gene/31033:ctu1 ^@ http://purl.uniprot.org/uniprot/H2UWQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. http://togogenome.org/gene/31033:rhag-1 ^@ http://purl.uniprot.org/uniprot/Q7T3R8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Cell membrane|||Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.|||Membrane http://togogenome.org/gene/31033:LOC101064186 ^@ http://purl.uniprot.org/uniprot/H2V821 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:taf7l ^@ http://purl.uniprot.org/uniprot/A0A674MN36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF7 family.|||Nucleus http://togogenome.org/gene/31033:cad ^@ http://purl.uniprot.org/uniprot/A0A674NCI2 ^@ Similarity ^@ In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily. http://togogenome.org/gene/31033:rnps1 ^@ http://purl.uniprot.org/uniprot/H2TA89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the splicing factor SR family.|||Nucleus speckle http://togogenome.org/gene/31033:itga8 ^@ http://purl.uniprot.org/uniprot/H2U873 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/31033:LOC101063630 ^@ http://purl.uniprot.org/uniprot/A0A3B5K4H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/31033:acss2 ^@ http://purl.uniprot.org/uniprot/H2TZK4 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/31033:LOC105416191 ^@ http://purl.uniprot.org/uniprot/H2T673 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/31033:cbl ^@ http://purl.uniprot.org/uniprot/A0A674MP59 ^@ Domain|||Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.|||The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. http://togogenome.org/gene/31033:kmt5b ^@ http://purl.uniprot.org/uniprot/A0A3B5KSP4 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/31033:LOC101072887 ^@ http://purl.uniprot.org/uniprot/H2TRU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/31033:LOC101075224 ^@ http://purl.uniprot.org/uniprot/H2U7M2 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Does not have a catalytic activity. http://togogenome.org/gene/31033:rnd3 ^@ http://purl.uniprot.org/uniprot/A0A674NK30 ^@ Function ^@ Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. http://togogenome.org/gene/31033:nlgn2a ^@ http://purl.uniprot.org/uniprot/D2X2G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101066247 ^@ http://purl.uniprot.org/uniprot/A0A3B5KBA7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101079608 ^@ http://purl.uniprot.org/uniprot/H2TAG4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. http://togogenome.org/gene/31033:LOC101070140 ^@ http://purl.uniprot.org/uniprot/H2U1B0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:ccdc86 ^@ http://purl.uniprot.org/uniprot/A0A3B5K034 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101070322 ^@ http://purl.uniprot.org/uniprot/A0A674MZM2 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/31033:LOC101074770 ^@ http://purl.uniprot.org/uniprot/A0A3B5K8L5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/31033:mtf2 ^@ http://purl.uniprot.org/uniprot/H2SJM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/31033:LOC101065136 ^@ http://purl.uniprot.org/uniprot/A0A674NQN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane http://togogenome.org/gene/31033:agbl5 ^@ http://purl.uniprot.org/uniprot/H2VAP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Midbody|||Nucleus|||cytosol|||spindle http://togogenome.org/gene/31033:LOC101079909 ^@ http://purl.uniprot.org/uniprot/H2V4M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/31033:med20 ^@ http://purl.uniprot.org/uniprot/H2TCJ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 20 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/31033:tlcd2 ^@ http://purl.uniprot.org/uniprot/A0A3B5K592 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:dynlt3 ^@ http://purl.uniprot.org/uniprot/A0A674MJ23 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/31033:cstf1 ^@ http://purl.uniprot.org/uniprot/H2SA09 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:timm9 ^@ http://purl.uniprot.org/uniprot/H2SJJ4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/31033:LOC101070269 ^@ http://purl.uniprot.org/uniprot/A0A674PBT7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101075951 ^@ http://purl.uniprot.org/uniprot/A0A674MKM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:LOC101076131 ^@ http://purl.uniprot.org/uniprot/A0A674P9I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AMY1 family.|||Nucleus http://togogenome.org/gene/31033:rad51 ^@ http://purl.uniprot.org/uniprot/A0A3B5KBZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Nucleus|||Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair. http://togogenome.org/gene/31033:vps51 ^@ http://purl.uniprot.org/uniprot/A0A674MM01|||http://purl.uniprot.org/uniprot/H2RQV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS51 family.|||Component of the Golgi-associated retrograde protein (GARP) complex. Component of the endosome-associated retrograde protein (EARP) complex.|||Endosome|||Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling.|||Recycling endosome|||trans-Golgi network http://togogenome.org/gene/31033:rack1 ^@ http://purl.uniprot.org/uniprot/H2RMD4 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. http://togogenome.org/gene/31033:ppcs ^@ http://purl.uniprot.org/uniprot/A0A3B5KL16 ^@ Similarity ^@ Belongs to the PPC synthetase family. http://togogenome.org/gene/31033:LOC101079195 ^@ http://purl.uniprot.org/uniprot/A0A674NJ66 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/31033:LOC445956 ^@ http://purl.uniprot.org/uniprot/H2U643 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAMP family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/31033:LOC101069875 ^@ http://purl.uniprot.org/uniprot/A0A674MU59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:mpc2 ^@ http://purl.uniprot.org/uniprot/H2U1Q4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/31033:get4 ^@ http://purl.uniprot.org/uniprot/A4GWN3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of a cytosolic protein quality control complex, the bag6/bat3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The bag6/bat3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Similarly, the bag6/bat3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The bag6/bat3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.|||Belongs to the GET4 family.|||Component of the bag6/bat3 complex.|||cytosol http://togogenome.org/gene/31033:LOC101064734 ^@ http://purl.uniprot.org/uniprot/H2T3T2 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/31033:ccdc124 ^@ http://purl.uniprot.org/uniprot/H2TMA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC124 family.|||Midbody http://togogenome.org/gene/31033:LOC101073239 ^@ http://purl.uniprot.org/uniprot/H2UHN0 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/31033:atp5md ^@ http://purl.uniprot.org/uniprot/A0A3B5K248 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion membrane http://togogenome.org/gene/31033:babam1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KE12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BABAM1 family.|||Nucleus http://togogenome.org/gene/31033:armc1 ^@ http://purl.uniprot.org/uniprot/A0A674PF83 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/31033:pno1 ^@ http://purl.uniprot.org/uniprot/H2U3T0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/31033:ctnnb1 ^@ http://purl.uniprot.org/uniprot/H2S791 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/31033:il-21 ^@ http://purl.uniprot.org/uniprot/Q599U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/31033:parp16 ^@ http://purl.uniprot.org/uniprot/H2SQF4 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/31033:LOC101078264 ^@ http://purl.uniprot.org/uniprot/H2UXH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM205 family.|||Membrane http://togogenome.org/gene/31033:tmem45b ^@ http://purl.uniprot.org/uniprot/H2V2U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/31033:rpl37 ^@ http://purl.uniprot.org/uniprot/H2VAM2 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/31033:LOC101071494 ^@ http://purl.uniprot.org/uniprot/H2U4I2 ^@ Similarity ^@ Belongs to the YY transcription factor family. http://togogenome.org/gene/31033:LOC101070467 ^@ http://purl.uniprot.org/uniprot/A0A3B5KNF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/31033:LOC101067834 ^@ http://purl.uniprot.org/uniprot/H2SIP5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:ehhadh ^@ http://purl.uniprot.org/uniprot/H2TN79 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/31033:wdpcp ^@ http://purl.uniprot.org/uniprot/H2TTM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat fritz family.|||Cell membrane|||Membrane|||cilium axoneme http://togogenome.org/gene/31033:LOC101079549 ^@ http://purl.uniprot.org/uniprot/A0A3B5K5U3 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/31033:gipc2 ^@ http://purl.uniprot.org/uniprot/H2SC34 ^@ Similarity ^@ Belongs to the GIPC family. http://togogenome.org/gene/31033:LOC101078740 ^@ http://purl.uniprot.org/uniprot/H2V4E5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/31033:LOC101063197 ^@ http://purl.uniprot.org/uniprot/H2SL37 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/31033:LOC101067006 ^@ http://purl.uniprot.org/uniprot/A0A674MUW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101077609 ^@ http://purl.uniprot.org/uniprot/A0A6E7TWQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/31033:rps19bp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K7H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AROS family.|||nucleolus http://togogenome.org/gene/31033:eya3 ^@ http://purl.uniprot.org/uniprot/H2TXZ7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/31033:cnp-3 ^@ http://purl.uniprot.org/uniprot/Q805D4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Exhibits natriuretic and vasodepressant activity. Has cGMP-stimulating activity. May help to regulate body fluid homeostasis in a variety of aquatic environments.|||Secreted http://togogenome.org/gene/31033:LOC101061869 ^@ http://purl.uniprot.org/uniprot/H2SW28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/31033:rnf13 ^@ http://purl.uniprot.org/uniprot/H2V608 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101073275 ^@ http://purl.uniprot.org/uniprot/A0A3B5K0W8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:slu7 ^@ http://purl.uniprot.org/uniprot/A0A674PCT8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SLU7 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/31033:fam136a ^@ http://purl.uniprot.org/uniprot/H2TN21 ^@ Similarity ^@ Belongs to the FAM136 family. http://togogenome.org/gene/31033:tbr1 ^@ http://purl.uniprot.org/uniprot/H2SJ50 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/31033:LOC101074997 ^@ http://purl.uniprot.org/uniprot/H2SLA2 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.|||Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. http://togogenome.org/gene/31033:c5h11orf88 ^@ http://purl.uniprot.org/uniprot/H2RMM0 ^@ Similarity ^@ Belongs to the HOATZ family. http://togogenome.org/gene/31033:plcd1 ^@ http://purl.uniprot.org/uniprot/H2V6M8 ^@ Cofactor ^@ Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain. http://togogenome.org/gene/31033:gab2 ^@ http://purl.uniprot.org/uniprot/H2UBR1 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/31033:fgfr1op2 ^@ http://purl.uniprot.org/uniprot/H2SE25 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/31033:LOC101073638 ^@ http://purl.uniprot.org/uniprot/A0A674PH27 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/31033:wnt6 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZP1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/31033:cog7 ^@ http://purl.uniprot.org/uniprot/H2UGQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG7 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:LOC101070876 ^@ http://purl.uniprot.org/uniprot/H2TC50 ^@ Similarity ^@ Belongs to the CNKSR family. http://togogenome.org/gene/31033:LOC101074499 ^@ http://purl.uniprot.org/uniprot/H2SQS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/31033:LOC101074730 ^@ http://purl.uniprot.org/uniprot/H2TT08 ^@ Similarity ^@ Belongs to the PTEN phosphatase protein family. http://togogenome.org/gene/31033:hsp90b1 ^@ http://purl.uniprot.org/uniprot/H2V2R8 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/31033:mak16 ^@ http://purl.uniprot.org/uniprot/H2TWV2 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/31033:hspb1 ^@ http://purl.uniprot.org/uniprot/A0A674PKS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||spindle http://togogenome.org/gene/31033:b4galt4 ^@ http://purl.uniprot.org/uniprot/H2V221 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/31033:LOC101079597 ^@ http://purl.uniprot.org/uniprot/H2UX11 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/31033:LOC101063501 ^@ http://purl.uniprot.org/uniprot/H2U5C0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC105419977 ^@ http://purl.uniprot.org/uniprot/A0A3B5KD15|||http://purl.uniprot.org/uniprot/A0A674MRH6|||http://purl.uniprot.org/uniprot/Q1KKU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Belongs to the Antp homeobox family. Deformed subfamily.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:dipk1a ^@ http://purl.uniprot.org/uniprot/H2SIQ0 ^@ Similarity ^@ Belongs to the DIPK family. http://togogenome.org/gene/31033:btg1 ^@ http://purl.uniprot.org/uniprot/A0A674NQ03 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/31033:ttc4 ^@ http://purl.uniprot.org/uniprot/H2VE81 ^@ Similarity ^@ Belongs to the TTC4 family. http://togogenome.org/gene/31033:nmbr ^@ http://purl.uniprot.org/uniprot/H2UA47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101071319 ^@ http://purl.uniprot.org/uniprot/A0A674NTW6|||http://purl.uniprot.org/uniprot/H2SMY8 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/31033:LOC101076376 ^@ http://purl.uniprot.org/uniprot/A0A674N9Q4|||http://purl.uniprot.org/uniprot/H2TX31 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/31033:urod ^@ http://purl.uniprot.org/uniprot/H2S7Q7 ^@ Similarity|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Homodimer. http://togogenome.org/gene/31033:LOC101061159 ^@ http://purl.uniprot.org/uniprot/A0A674MFM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/31033:LOC101062398 ^@ http://purl.uniprot.org/uniprot/H2SWJ8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:unc45b ^@ http://purl.uniprot.org/uniprot/A0A674MWX1 ^@ Subcellular Location Annotation ^@ perinuclear region http://togogenome.org/gene/31033:tom1 ^@ http://purl.uniprot.org/uniprot/H2SV93 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/31033:etfdh ^@ http://purl.uniprot.org/uniprot/H2UWL6 ^@ Cofactor|||Function ^@ Accepts electrons from ETF and reduces ubiquinone.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/31033:maco1 ^@ http://purl.uniprot.org/uniprot/Q2TLY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the macoilin family.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/31033:per2 ^@ http://purl.uniprot.org/uniprot/H2SWF5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/31033:mindy1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KDM2 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM63 subfamily.|||Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. http://togogenome.org/gene/31033:tbc1d24 ^@ http://purl.uniprot.org/uniprot/H2UJG0 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasmic vesicle membrane|||Interacts with ARF6.|||Membrane|||Presynapse http://togogenome.org/gene/31033:LOC101065843 ^@ http://purl.uniprot.org/uniprot/A0A674NXA6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101063191 ^@ http://purl.uniprot.org/uniprot/H2UL58 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/31033:KEF89_p07 ^@ http://purl.uniprot.org/uniprot/Q8HCV9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane http://togogenome.org/gene/31033:vgll3 ^@ http://purl.uniprot.org/uniprot/H2SBW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||Nucleus http://togogenome.org/gene/31033:LOC101068873 ^@ http://purl.uniprot.org/uniprot/H2RKA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/31033:ptx3 ^@ http://purl.uniprot.org/uniprot/A0A674N0X7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:slc35b2 ^@ http://purl.uniprot.org/uniprot/A0A674NI59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/31033:ndufs7 ^@ http://purl.uniprot.org/uniprot/H2S712 ^@ Similarity ^@ Belongs to the complex I 20 kDa subunit family. http://togogenome.org/gene/31033:rps17 ^@ http://purl.uniprot.org/uniprot/H2UH56 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/31033:zfy ^@ http://purl.uniprot.org/uniprot/H2V292 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:a1cf ^@ http://purl.uniprot.org/uniprot/H2RWQ2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:LOC101063282 ^@ http://purl.uniprot.org/uniprot/A0A3B5KK94 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/31033:LOC101067632 ^@ http://purl.uniprot.org/uniprot/H2SF35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.|||Membrane http://togogenome.org/gene/31033:LOC101071498 ^@ http://purl.uniprot.org/uniprot/O57655 ^@ Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. http://togogenome.org/gene/31033:LOC101065256 ^@ http://purl.uniprot.org/uniprot/H2RSI5 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/31033:mdh1 ^@ http://purl.uniprot.org/uniprot/H2TUM0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family.|||Homodimer.|||Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). http://togogenome.org/gene/31033:cert1 ^@ http://purl.uniprot.org/uniprot/H2T1Y0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Golgi apparatus http://togogenome.org/gene/31033:pitx2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KCK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:dusp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K6M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/31033:snrpa ^@ http://purl.uniprot.org/uniprot/H2TI81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM U1 A/B'' family.|||Nucleus http://togogenome.org/gene/31033:LOC101079979 ^@ http://purl.uniprot.org/uniprot/H2UGW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/31033:xkr8 ^@ http://purl.uniprot.org/uniprot/Q5GH46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/31033:cenpx ^@ http://purl.uniprot.org/uniprot/A0A3B5K538 ^@ Similarity ^@ Belongs to the CENP-X/MHF2 family. http://togogenome.org/gene/31033:smad9 ^@ http://purl.uniprot.org/uniprot/H2RRM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:LOC101067317 ^@ http://purl.uniprot.org/uniprot/H2T857 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/31033:LOC101076291 ^@ http://purl.uniprot.org/uniprot/A0A3B5K2D4|||http://purl.uniprot.org/uniprot/A0A3B5KJY0 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/31033:acat1 ^@ http://purl.uniprot.org/uniprot/H2S0Z3 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/31033:LOC101065654 ^@ http://purl.uniprot.org/uniprot/A0A3B5KMX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/31033:LOC105418355 ^@ http://purl.uniprot.org/uniprot/H2SK94 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/31033:adgrf1 ^@ http://purl.uniprot.org/uniprot/Q08KN2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:gtf2f2 ^@ http://purl.uniprot.org/uniprot/A0A3B5JUK5|||http://purl.uniprot.org/uniprot/A0A3B5JZM8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF beta subunit family.|||Nucleus|||TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. http://togogenome.org/gene/31033:slc22a18 ^@ http://purl.uniprot.org/uniprot/A0A3B5K724 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101065656 ^@ http://purl.uniprot.org/uniprot/H2T5C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 75 kDa subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:maf1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KMV2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAF1 family.|||Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.|||Nucleus http://togogenome.org/gene/31033:ate1 ^@ http://purl.uniprot.org/uniprot/A0A674MAI8|||http://purl.uniprot.org/uniprot/A0A674MHQ2 ^@ Function|||Similarity ^@ Belongs to the R-transferase family.|||Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. http://togogenome.org/gene/31033:LOC101066955 ^@ http://purl.uniprot.org/uniprot/A0A3B5K980 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/31033:mapre1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KI06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/31033:LOC101077836 ^@ http://purl.uniprot.org/uniprot/A0A3B5KQE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF beta subunit family.|||Nucleus http://togogenome.org/gene/31033:LOC101069451 ^@ http://purl.uniprot.org/uniprot/H2SRX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.|||Membrane http://togogenome.org/gene/31033:c6h18orf25 ^@ http://purl.uniprot.org/uniprot/A0A3B5KAB6|||http://purl.uniprot.org/uniprot/A0A3B5KBE9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:ficd ^@ http://purl.uniprot.org/uniprot/H2UGZ8 ^@ Similarity ^@ Belongs to the fic family. http://togogenome.org/gene/31033:rps12 ^@ http://purl.uniprot.org/uniprot/A0A674P0G1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family. http://togogenome.org/gene/31033:LOC101063193 ^@ http://purl.uniprot.org/uniprot/H2TFZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101071645 ^@ http://purl.uniprot.org/uniprot/H2TQW6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/31033:eml2 ^@ http://purl.uniprot.org/uniprot/H2UWR8 ^@ Similarity ^@ Belongs to the WD repeat EMAP family. http://togogenome.org/gene/31033:ppih ^@ http://purl.uniprot.org/uniprot/H2UQR6 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/31033:LOC101076595 ^@ http://purl.uniprot.org/uniprot/H2U5V3 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/31033:LOC101065234 ^@ http://purl.uniprot.org/uniprot/H2THC8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.|||Cytoplasm|||Membrane http://togogenome.org/gene/31033:sbds ^@ http://purl.uniprot.org/uniprot/A0A3B5KP44 ^@ Function|||Similarity ^@ Belongs to the SDO1/SBDS family.|||Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. http://togogenome.org/gene/31033:tpst1 ^@ http://purl.uniprot.org/uniprot/H2U9A8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein sulfotransferase family.|||Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.|||Golgi apparatus membrane http://togogenome.org/gene/31033:stambp ^@ http://purl.uniprot.org/uniprot/H2UP12 ^@ Similarity ^@ Belongs to the peptidase M67C family. http://togogenome.org/gene/31033:med30 ^@ http://purl.uniprot.org/uniprot/H2S969 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 30 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/31033:LOC101061591 ^@ http://purl.uniprot.org/uniprot/A0A3B5KKA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM263 family.|||Membrane http://togogenome.org/gene/31033:rpl17 ^@ http://purl.uniprot.org/uniprot/A0A3B5KR88 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/31033:hddc2 ^@ http://purl.uniprot.org/uniprot/H2UKJ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HDDC2 family.|||Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).|||Homodimer. http://togogenome.org/gene/31033:LOC101069242 ^@ http://purl.uniprot.org/uniprot/A0A674PRJ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.|||Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.|||Membrane|||This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. http://togogenome.org/gene/31033:gcdh ^@ http://purl.uniprot.org/uniprot/H2T7M2 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/31033:cxcl13 ^@ http://purl.uniprot.org/uniprot/E5RMA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/31033:LOC101078836 ^@ http://purl.uniprot.org/uniprot/A0A674N5L3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:tnfaip6 ^@ http://purl.uniprot.org/uniprot/H2UU15 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101075563 ^@ http://purl.uniprot.org/uniprot/H2V8F4 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the aldo/keto reductase family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/31033:pde4b ^@ http://purl.uniprot.org/uniprot/A0A674PR18 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/31033:LOC101073205 ^@ http://purl.uniprot.org/uniprot/A0A6D2XZ98 ^@ Similarity ^@ In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.|||In the N-terminal section; belongs to the glutamate 5-kinase family. http://togogenome.org/gene/31033:LOC101070901 ^@ http://purl.uniprot.org/uniprot/H2U457 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the retinoblastoma protein (RB) family.|||Nucleus http://togogenome.org/gene/31033:mab21l2 ^@ http://purl.uniprot.org/uniprot/H2T290 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/31033:wnt10b ^@ http://purl.uniprot.org/uniprot/H2TUW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/31033:LOC101070684 ^@ http://purl.uniprot.org/uniprot/H2STM0 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/31033:tfcp2 ^@ http://purl.uniprot.org/uniprot/H2UMA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/31033:LOC101067527 ^@ http://purl.uniprot.org/uniprot/H2RTM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tdpoz family.|||Nucleus speckle http://togogenome.org/gene/31033:LOC101079430 ^@ http://purl.uniprot.org/uniprot/H2T510 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:ugcg ^@ http://purl.uniprot.org/uniprot/H2T1G9 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/31033:asz1 ^@ http://purl.uniprot.org/uniprot/Q9I8E3 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with DDX4, PIWIL1, RANBP9 and TDRD1. http://togogenome.org/gene/31033:LOC101074584 ^@ http://purl.uniprot.org/uniprot/H2U981 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.|||extracellular matrix http://togogenome.org/gene/31033:ssr1 ^@ http://purl.uniprot.org/uniprot/A0A674PNE6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-alpha family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. http://togogenome.org/gene/31033:LOC101072687 ^@ http://purl.uniprot.org/uniprot/A0A3B5KD80 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/31033:med8 ^@ http://purl.uniprot.org/uniprot/H2V005 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 8 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/31033:LOC101068057 ^@ http://purl.uniprot.org/uniprot/A1KXU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:LOC101075889 ^@ http://purl.uniprot.org/uniprot/H2UXP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the flagellar radial spoke RSP3 family.|||flagellum axoneme http://togogenome.org/gene/31033:supt5h ^@ http://purl.uniprot.org/uniprot/H2RZ98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT5 family.|||Nucleus http://togogenome.org/gene/31033:LOC101069170 ^@ http://purl.uniprot.org/uniprot/H2RWL3 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/31033:LOC101079583 ^@ http://purl.uniprot.org/uniprot/A0A674MIU8 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/31033:LOC101065443 ^@ http://purl.uniprot.org/uniprot/H2TTX5 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/31033:gpn2 ^@ http://purl.uniprot.org/uniprot/H2UA84 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/31033:LOC101064386 ^@ http://purl.uniprot.org/uniprot/Q1KKS2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme c group covalently per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).|||Mitochondrion intermembrane space http://togogenome.org/gene/31033:LOC101065232 ^@ http://purl.uniprot.org/uniprot/H2T7H4 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/31033:clic4 ^@ http://purl.uniprot.org/uniprot/H2RW98 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/31033:LOC101065176 ^@ http://purl.uniprot.org/uniprot/A0A674MWG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:LOC101071061 ^@ http://purl.uniprot.org/uniprot/A0A674NWX8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/31033:LOC101065025 ^@ http://purl.uniprot.org/uniprot/H2RIY1 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/31033:rpe ^@ http://purl.uniprot.org/uniprot/A0A674NX86 ^@ Cofactor|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/31033:LOC101080153 ^@ http://purl.uniprot.org/uniprot/H2SQ99 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/31033:sugt1 ^@ http://purl.uniprot.org/uniprot/H2TES5 ^@ Similarity ^@ Belongs to the SGT1 family. http://togogenome.org/gene/31033:rag2 ^@ http://purl.uniprot.org/uniprot/Q9W6A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAG2 family.|||Nucleus http://togogenome.org/gene/31033:LOC101071719 ^@ http://purl.uniprot.org/uniprot/O57656 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.|||Cytoplasm|||Has glycerol-3-phosphate dehydrogenase activity.|||Homodimer. http://togogenome.org/gene/31033:ovca2 ^@ http://purl.uniprot.org/uniprot/A0A674PG14 ^@ Similarity ^@ Belongs to the LovG family. http://togogenome.org/gene/31033:st3gal3 ^@ http://purl.uniprot.org/uniprot/H2T264|||http://purl.uniprot.org/uniprot/Q702S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/31033:fgb ^@ http://purl.uniprot.org/uniprot/H2S183 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/31033:mfsd4a ^@ http://purl.uniprot.org/uniprot/H2UAH9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101062185 ^@ http://purl.uniprot.org/uniprot/A0A6D2WSK7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101063778 ^@ http://purl.uniprot.org/uniprot/A0A3B5K329 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/31033:LOC101066261 ^@ http://purl.uniprot.org/uniprot/H2RM84 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/31033:ak2 ^@ http://purl.uniprot.org/uniprot/H2RRV5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK2 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Mitochondrion intermembrane space|||Monomer. http://togogenome.org/gene/31033:LOC101066292 ^@ http://purl.uniprot.org/uniprot/A0A3B5KE99 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/31033:yipf5 ^@ http://purl.uniprot.org/uniprot/H2SS94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/31033:LOC101066661 ^@ http://purl.uniprot.org/uniprot/A0A3B5K775 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:tmem9 ^@ http://purl.uniprot.org/uniprot/H2UBV5 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/31033:surf4 ^@ http://purl.uniprot.org/uniprot/O57590 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF4 family.|||Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion. Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins. http://togogenome.org/gene/31033:LOC105417859 ^@ http://purl.uniprot.org/uniprot/A0A674MRE8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101076407 ^@ http://purl.uniprot.org/uniprot/A0A674NGP5 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/31033:LOC101064989 ^@ http://purl.uniprot.org/uniprot/A0A674P3U5 ^@ Similarity ^@ Belongs to the RBR family. http://togogenome.org/gene/31033:dusp8 ^@ http://purl.uniprot.org/uniprot/H2SZX1 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/31033:stxbp2 ^@ http://purl.uniprot.org/uniprot/H2UMA3 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/31033:tmem178b ^@ http://purl.uniprot.org/uniprot/H2U0E8 ^@ Similarity ^@ Belongs to the TMEM178 family. http://togogenome.org/gene/31033:anxa10 ^@ http://purl.uniprot.org/uniprot/A0A674NH77 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/31033:slc25a28 ^@ http://purl.uniprot.org/uniprot/H2SYD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:copg2 ^@ http://purl.uniprot.org/uniprot/H2UTW1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/31033:csnk1g1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K9C2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/31033:LOC101077436 ^@ http://purl.uniprot.org/uniprot/H2T248 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with JUN family members.|||Nucleus|||Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation. In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes. Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation. In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening. http://togogenome.org/gene/31033:itpk1 ^@ http://purl.uniprot.org/uniprot/H2T0A5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the ITPK1 family.|||Binds 2 magnesium ions per subunit.|||Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.|||Monomer. http://togogenome.org/gene/31033:LOC101069761 ^@ http://purl.uniprot.org/uniprot/H2URM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/31033:LOC101074085 ^@ http://purl.uniprot.org/uniprot/A0A3B5K3E3 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/31033:LOC101069528 ^@ http://purl.uniprot.org/uniprot/H2T7B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:degs2 ^@ http://purl.uniprot.org/uniprot/A0A674NN05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:nr2f6 ^@ http://purl.uniprot.org/uniprot/H2SD73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/31033:LOC101063605 ^@ http://purl.uniprot.org/uniprot/A0A674NCK1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/31033:dct ^@ http://purl.uniprot.org/uniprot/Q8QGN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/31033:rpl11 ^@ http://purl.uniprot.org/uniprot/A0A3B5KKK2|||http://purl.uniprot.org/uniprot/A0A674MUT3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL5 family. http://togogenome.org/gene/31033:cpsf4 ^@ http://purl.uniprot.org/uniprot/A0A674P853 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CPSF4/YTH1 family.|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex.|||Nucleus http://togogenome.org/gene/31033:LOC101066134 ^@ http://purl.uniprot.org/uniprot/A0A3B5JUD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:homer1 ^@ http://purl.uniprot.org/uniprot/A0A674MCP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/31033:vwc2 ^@ http://purl.uniprot.org/uniprot/H2V8Q5 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/31033:ino80 ^@ http://purl.uniprot.org/uniprot/H2U7Y4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.|||Belongs to the SNF2/RAD54 helicase family.|||Component of the INO80 chromatin-remodeling complex.|||Nucleus|||The DBINO region is involved in binding to DNA. http://togogenome.org/gene/31033:med22 ^@ http://purl.uniprot.org/uniprot/A0A674NQ09 ^@ Function|||Subcellular Location Annotation ^@ Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/31033:LOC105416438 ^@ http://purl.uniprot.org/uniprot/H2TLP9 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/31033:mct1a ^@ http://purl.uniprot.org/uniprot/E7FKY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/31033:LOC101079688 ^@ http://purl.uniprot.org/uniprot/A0A674MXD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/31033:LOC101072202 ^@ http://purl.uniprot.org/uniprot/H2RIY3 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/31033:slc25a19 ^@ http://purl.uniprot.org/uniprot/H2TR90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:sh3rf3 ^@ http://purl.uniprot.org/uniprot/H2SHK6 ^@ Similarity ^@ Belongs to the SH3RF family. http://togogenome.org/gene/31033:LOC101074401 ^@ http://purl.uniprot.org/uniprot/H2T292 ^@ Similarity ^@ Belongs to the FAM10 family. http://togogenome.org/gene/31033:rock2 ^@ http://purl.uniprot.org/uniprot/A0A674MUZ9|||http://purl.uniprot.org/uniprot/H2TR74 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by RHOA binding. Inhibited by Y-27632.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cytoplasm|||Homodimer.|||Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. http://togogenome.org/gene/31033:LOC101074692 ^@ http://purl.uniprot.org/uniprot/H2UFG2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101064901 ^@ http://purl.uniprot.org/uniprot/H2TTS8 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/31033:LOC101066739 ^@ http://purl.uniprot.org/uniprot/H2SQN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:mrps36 ^@ http://purl.uniprot.org/uniprot/A0A674P0K0 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/31033:hspa13 ^@ http://purl.uniprot.org/uniprot/A0A3B5KL77 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Binds UBQLN2.|||Endoplasmic reticulum|||Has peptide-independent ATPase activity.|||Microsome http://togogenome.org/gene/31033:ehd2 ^@ http://purl.uniprot.org/uniprot/H2TLF0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/31033:rpn1 ^@ http://purl.uniprot.org/uniprot/H2UDT7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/31033:LOC101076768 ^@ http://purl.uniprot.org/uniprot/H2RLI6 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/31033:LOC101067599 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZS7 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/31033:LOC101070555 ^@ http://purl.uniprot.org/uniprot/H2T9H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:hars ^@ http://purl.uniprot.org/uniprot/A0A3F2YPF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101063559 ^@ http://purl.uniprot.org/uniprot/A0A3B5K4R2 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/31033:LOC101062625 ^@ http://purl.uniprot.org/uniprot/H2TKT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted|||Somatostatin inhibits the release of somatotropin. http://togogenome.org/gene/31033:rpl30 ^@ http://purl.uniprot.org/uniprot/A0A674NDI3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/31033:LOC101061169 ^@ http://purl.uniprot.org/uniprot/H2TF22 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/31033:pes1 ^@ http://purl.uniprot.org/uniprot/H2UUQ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pescadillo family.|||Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.|||Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/31033:LOC101068343 ^@ http://purl.uniprot.org/uniprot/A0A674MZB0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:march4 ^@ http://purl.uniprot.org/uniprot/H2TSC1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:rpl9 ^@ http://purl.uniprot.org/uniprot/H2TEV3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/31033:pxmp2 ^@ http://purl.uniprot.org/uniprot/A0A674N0J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/31033:gprc5b ^@ http://purl.uniprot.org/uniprot/A0A674NYC2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:tp53bp2 ^@ http://purl.uniprot.org/uniprot/A0A674P3E1|||http://purl.uniprot.org/uniprot/H2U1S8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:wnt5a ^@ http://purl.uniprot.org/uniprot/A0A674P4T6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/31033:srf ^@ http://purl.uniprot.org/uniprot/H2V6U8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101067094 ^@ http://purl.uniprot.org/uniprot/H2UFA1 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101061479 ^@ http://purl.uniprot.org/uniprot/A0A3B5K167 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:apip ^@ http://purl.uniprot.org/uniprot/H2UX72 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aldolase class II family. Adducin subfamily.|||Belongs to the aldolase class II family. MtnB subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis.|||Cytoplasm http://togogenome.org/gene/31033:mrpl42 ^@ http://purl.uniprot.org/uniprot/A0A3B5KSN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL42 family.|||Mitochondrion http://togogenome.org/gene/31033:meox1 ^@ http://purl.uniprot.org/uniprot/H2SJ86 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:rtn1 ^@ http://purl.uniprot.org/uniprot/A0A674PN99|||http://purl.uniprot.org/uniprot/Q4G5X5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:glyctk ^@ http://purl.uniprot.org/uniprot/A0A3B5KAV1 ^@ Similarity ^@ Belongs to the glycerate kinase type-2 family. http://togogenome.org/gene/31033:LOC101066865 ^@ http://purl.uniprot.org/uniprot/H2RZW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GDNFR family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101068171 ^@ http://purl.uniprot.org/uniprot/H2TQY3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/31033:eif3m ^@ http://purl.uniprot.org/uniprot/H2SSK7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Belongs to the eIF-3 subunit M family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm http://togogenome.org/gene/31033:LOC101064861 ^@ http://purl.uniprot.org/uniprot/H2UGY0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101078451 ^@ http://purl.uniprot.org/uniprot/O42504 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:ccdc58 ^@ http://purl.uniprot.org/uniprot/H2V7P2 ^@ Similarity ^@ Belongs to the MIX23 family. http://togogenome.org/gene/31033:bap1 ^@ http://purl.uniprot.org/uniprot/H2UEV3 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/31033:pi4k2a ^@ http://purl.uniprot.org/uniprot/H2SZK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.|||Membrane http://togogenome.org/gene/31033:ftsj1 ^@ http://purl.uniprot.org/uniprot/H2UWE1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.|||Cytoplasm|||Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. http://togogenome.org/gene/31033:npepl1 ^@ http://purl.uniprot.org/uniprot/A0A674NA39 ^@ Similarity ^@ Belongs to the peptidase M17 family. http://togogenome.org/gene/31033:LOC101071653 ^@ http://purl.uniprot.org/uniprot/A0A3B5KE07 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/31033:LOC101068481 ^@ http://purl.uniprot.org/uniprot/H2U7B3 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/31033:phka2 ^@ http://purl.uniprot.org/uniprot/H2V3F0|||http://purl.uniprot.org/uniprot/H2V3F4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. http://togogenome.org/gene/31033:capn7 ^@ http://purl.uniprot.org/uniprot/H2SDL1 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/31033:pfdn2 ^@ http://purl.uniprot.org/uniprot/H2SE99 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/31033:LOC101075526 ^@ http://purl.uniprot.org/uniprot/A0A674N3A0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LIS1/nudF family.|||Can self-associate. Component of the cytosolic PAF-AH (I) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity (By similarity). Interacts with dynein, dynactin, nde1 and ndel1.|||Can self-associate. Interacts with dynein, dynactin, NDE1 and NDEL1.|||Dimerization mediated by the LisH domain may be required to activate dynein.|||Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.|||centrosome|||cytoskeleton http://togogenome.org/gene/31033:six1 ^@ http://purl.uniprot.org/uniprot/H2TQH5 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101072191 ^@ http://purl.uniprot.org/uniprot/A0A674MWB9 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101066436 ^@ http://purl.uniprot.org/uniprot/A0A3B5K9F7 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/31033:tiprl ^@ http://purl.uniprot.org/uniprot/H2T0T6 ^@ Similarity ^@ Belongs to the TIP41 family. http://togogenome.org/gene/31033:ebp ^@ http://purl.uniprot.org/uniprot/H2U6T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:LOC105417801 ^@ http://purl.uniprot.org/uniprot/A0A3B5KAC2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:uchl1 ^@ http://purl.uniprot.org/uniprot/H2UQN6 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/31033:LOC101069487 ^@ http://purl.uniprot.org/uniprot/H2T0I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:LOC101072547 ^@ http://purl.uniprot.org/uniprot/A0A674NXE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/31033:kcnk3 ^@ http://purl.uniprot.org/uniprot/H2V863 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/31033:LOC101076896 ^@ http://purl.uniprot.org/uniprot/H2TN23 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:bace1 ^@ http://purl.uniprot.org/uniprot/H2T442 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Endosome|||Membrane|||Membrane raft|||Recycling endosome|||trans-Golgi network http://togogenome.org/gene/31033:LOC101068916 ^@ http://purl.uniprot.org/uniprot/H2UTN8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101075574 ^@ http://purl.uniprot.org/uniprot/H2S5M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/31033:LOC101065496 ^@ http://purl.uniprot.org/uniprot/A0A674NFI3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101079915 ^@ http://purl.uniprot.org/uniprot/Q6E5R7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:cdk5rap3 ^@ http://purl.uniprot.org/uniprot/H2U2L6 ^@ Similarity ^@ Belongs to the CDK5RAP3 family. http://togogenome.org/gene/31033:tcf25 ^@ http://purl.uniprot.org/uniprot/H2VBE3 ^@ Similarity ^@ Belongs to the TCF25 family. http://togogenome.org/gene/31033:atp2a2 ^@ http://purl.uniprot.org/uniprot/A0A674MCU1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/31033:gskip ^@ http://purl.uniprot.org/uniprot/H2VC04 ^@ Similarity ^@ Belongs to the GSKIP family. http://togogenome.org/gene/31033:LOC101075767 ^@ http://purl.uniprot.org/uniprot/A0A674PJM8 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/31033:hikeshi ^@ http://purl.uniprot.org/uniprot/A0A3B5KJS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.|||Belongs to the OPI10 family.|||Cytoplasm|||Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.|||Nucleus|||cytosol http://togogenome.org/gene/31033:LOC101079676 ^@ http://purl.uniprot.org/uniprot/A0A674NUF6 ^@ Function|||Similarity|||Subunit ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family.|||Homotetramer. http://togogenome.org/gene/31033:mmpf1 ^@ http://purl.uniprot.org/uniprot/H2S6Q9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/31033:LOC101069051 ^@ http://purl.uniprot.org/uniprot/H2TLF6 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/31033:pggt1b ^@ http://purl.uniprot.org/uniprot/A0A674NPU9 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit beta family. http://togogenome.org/gene/31033:LOC101062666 ^@ http://purl.uniprot.org/uniprot/A0A674N787 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/31033:nck2 ^@ http://purl.uniprot.org/uniprot/H2UC75 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/31033:gosr2 ^@ http://purl.uniprot.org/uniprot/H2UHM1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOSR2 family.|||Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.|||Membrane http://togogenome.org/gene/31033:slc30a4 ^@ http://purl.uniprot.org/uniprot/A0A3B5K5B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/31033:LOC101072248 ^@ http://purl.uniprot.org/uniprot/H2U403 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/31033:LOC101066982 ^@ http://purl.uniprot.org/uniprot/A0A674NH54 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/31033:adssl1 ^@ http://purl.uniprot.org/uniprot/A0A674N4C5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.|||Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. http://togogenome.org/gene/31033:tp53i11 ^@ http://purl.uniprot.org/uniprot/A0A674P338 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101077756 ^@ http://purl.uniprot.org/uniprot/Q9DES1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus|||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. http://togogenome.org/gene/31033:LOC101072937 ^@ http://purl.uniprot.org/uniprot/Q7T077 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:lhfpl6 ^@ http://purl.uniprot.org/uniprot/H2UI19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101069969 ^@ http://purl.uniprot.org/uniprot/H2SYB4 ^@ Similarity ^@ In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/31033:timp4 ^@ http://purl.uniprot.org/uniprot/Q7ZTB0 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/31033:sart1 ^@ http://purl.uniprot.org/uniprot/Q9DF75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNU66/SART1 family.|||Nucleus http://togogenome.org/gene/31033:ccna2 ^@ http://purl.uniprot.org/uniprot/H2SY68 ^@ Function|||Similarity|||Subunit ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. http://togogenome.org/gene/31033:LOC101062924 ^@ http://purl.uniprot.org/uniprot/A0A674P3T8 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/31033:ppp2r5e ^@ http://purl.uniprot.org/uniprot/A0A674PGU3 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family. http://togogenome.org/gene/31033:il1b ^@ http://purl.uniprot.org/uniprot/H2UVE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/31033:srp72 ^@ http://purl.uniprot.org/uniprot/H2TJ53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP72 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).|||Cytoplasm http://togogenome.org/gene/31033:LOC101070913 ^@ http://purl.uniprot.org/uniprot/H2V3T0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. LISCH7 family.|||Membrane|||tight junction http://togogenome.org/gene/31033:nlgn1 ^@ http://purl.uniprot.org/uniprot/D2X2G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101070190 ^@ http://purl.uniprot.org/uniprot/A0A674P5Z6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/31033:LOC445941 ^@ http://purl.uniprot.org/uniprot/Q804X0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular space http://togogenome.org/gene/31033:LOC101075610 ^@ http://purl.uniprot.org/uniprot/H2U9I0 ^@ Subcellular Location Annotation|||Subunit ^@ Forms a complex composed of PDGFRL, TNK2 and GRB2.|||Membrane http://togogenome.org/gene/31033:LOC101077372 ^@ http://purl.uniprot.org/uniprot/A0A3B5KDD7 ^@ Similarity ^@ Belongs to the ZAR1 family. http://togogenome.org/gene/31033:LOC101066792 ^@ http://purl.uniprot.org/uniprot/H2TNW0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Cell membrane|||Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:LOC101066482 ^@ http://purl.uniprot.org/uniprot/A0A674P431 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/31033:LOC101061816 ^@ http://purl.uniprot.org/uniprot/H2TQ81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/31033:ganab ^@ http://purl.uniprot.org/uniprot/A0A674NYR6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/31033:LOC101072346 ^@ http://purl.uniprot.org/uniprot/H2TV93 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LIS1/nudF family.|||Can self-associate. Component of the cytosolic PAF-AH (I) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity (By similarity). Interacts with dynein, dynactin, nde1 and ndel1.|||Can self-associate. Interacts with dynein, dynactin, NDE1 and NDEL1.|||Dimerization mediated by the LisH domain may be required to activate dynein.|||Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.|||centrosome|||cytoskeleton http://togogenome.org/gene/31033:st6gal1 ^@ http://purl.uniprot.org/uniprot/Q6KB62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/31033:calcr ^@ http://purl.uniprot.org/uniprot/A7Z0B8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Interacts with GPRASP2.|||Membrane http://togogenome.org/gene/31033:cyp17a1 ^@ http://purl.uniprot.org/uniprot/A7U484 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/31033:LOC101062889 ^@ http://purl.uniprot.org/uniprot/H2SSV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/31033:smn ^@ http://purl.uniprot.org/uniprot/A8WEN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMN family.|||Cajal body|||Perikaryon|||Z line|||gem|||neuron projection http://togogenome.org/gene/31033:LOC101068939 ^@ http://purl.uniprot.org/uniprot/A0A6D2XGU2 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/31033:LOC101065389 ^@ http://purl.uniprot.org/uniprot/A0A674PHD6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:st6galnac6 ^@ http://purl.uniprot.org/uniprot/A0A674PH18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/31033:lgi1 ^@ http://purl.uniprot.org/uniprot/Q1EGK1 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/31033:nus1 ^@ http://purl.uniprot.org/uniprot/A0A674MGN0 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/31033:tmem244 ^@ http://purl.uniprot.org/uniprot/A0A3B5KBS2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101074303 ^@ http://purl.uniprot.org/uniprot/H2U3I7 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/31033:prpf4b ^@ http://purl.uniprot.org/uniprot/H2T844 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.|||Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF. http://togogenome.org/gene/31033:LOC101072875 ^@ http://purl.uniprot.org/uniprot/H2RX32 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/31033:dipk1b ^@ http://purl.uniprot.org/uniprot/H2SWL1 ^@ Similarity ^@ Belongs to the DIPK family. http://togogenome.org/gene/31033:edc3 ^@ http://purl.uniprot.org/uniprot/H2V3H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EDC3 family.|||P-body http://togogenome.org/gene/31033:dpt ^@ http://purl.uniprot.org/uniprot/A0A3B5K3W6 ^@ Similarity ^@ Belongs to the dermatopontin family. http://togogenome.org/gene/31033:cldn32a ^@ http://purl.uniprot.org/uniprot/Q6E5S7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:itprip ^@ http://purl.uniprot.org/uniprot/Q90XY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Cell membrane|||Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.|||Nucleus outer membrane http://togogenome.org/gene/31033:LOC101071112 ^@ http://purl.uniprot.org/uniprot/A0A674P5X5 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/31033:LOC101075674 ^@ http://purl.uniprot.org/uniprot/H2SY23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/31033:LOC101067847 ^@ http://purl.uniprot.org/uniprot/A0A674PME2 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/31033:LOC101071539 ^@ http://purl.uniprot.org/uniprot/A0A674NDJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTF2H2 family.|||Nucleus http://togogenome.org/gene/31033:mark4 ^@ http://purl.uniprot.org/uniprot/H2STG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/31033:gabrb3 ^@ http://purl.uniprot.org/uniprot/A0A674NI38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/31033:LOC101068594 ^@ http://purl.uniprot.org/uniprot/A0A6I8PS55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/31033:LOC101065506 ^@ http://purl.uniprot.org/uniprot/A0A3B5K5U2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. http://togogenome.org/gene/31033:dpy30 ^@ http://purl.uniprot.org/uniprot/H2U059 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/31033:dmrta2 ^@ http://purl.uniprot.org/uniprot/Q4AE28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||May be involved in sexual development.|||Nucleus http://togogenome.org/gene/31033:atp6v1f ^@ http://purl.uniprot.org/uniprot/H2RMX7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase F subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/31033:npy8ar ^@ http://purl.uniprot.org/uniprot/A7XY86 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:mapre3 ^@ http://purl.uniprot.org/uniprot/H2TFC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/31033:LOC101068270 ^@ http://purl.uniprot.org/uniprot/Q8AV21 ^@ Similarity ^@ Belongs to the SERBP1-HABP4 family. http://togogenome.org/gene/31033:LOC101073356 ^@ http://purl.uniprot.org/uniprot/A0A3B5K6U0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS7 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/31033:LOC101069587 ^@ http://purl.uniprot.org/uniprot/H2T679 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Cytoplasm http://togogenome.org/gene/31033:sox14 ^@ http://purl.uniprot.org/uniprot/Q6WNT8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:atad2b ^@ http://purl.uniprot.org/uniprot/H2SMJ1 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/31033:LOC101069210 ^@ http://purl.uniprot.org/uniprot/A0A3B5K7B1 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/31033:LOC101073138 ^@ http://purl.uniprot.org/uniprot/H2ST59 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:dhrsx ^@ http://purl.uniprot.org/uniprot/A0A674NC98 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/31033:LOC101061350 ^@ http://purl.uniprot.org/uniprot/A0A674MPG4 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Membrane|||basement membrane http://togogenome.org/gene/31033:cnp-2 ^@ http://purl.uniprot.org/uniprot/Q805D5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Exhibits natriuretic and vasodepressant activity. Has cGMP-stimulating activity. May help to regulate body fluid homeostasis in a variety of aquatic environments.|||Secreted http://togogenome.org/gene/31033:cdk2ap1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KMQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDK2AP family.|||Nucleus http://togogenome.org/gene/31033:LOC101075255 ^@ http://purl.uniprot.org/uniprot/H2TMH9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/31033:ube4b ^@ http://purl.uniprot.org/uniprot/H2TTD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101063826 ^@ http://purl.uniprot.org/uniprot/A0A674MIZ6 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/31033:dr1 ^@ http://purl.uniprot.org/uniprot/H2UZZ9 ^@ Similarity ^@ Belongs to the NC2 beta/DR1 family. http://togogenome.org/gene/31033:LOC101076451 ^@ http://purl.uniprot.org/uniprot/H2RQA0 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/31033:cdh22 ^@ http://purl.uniprot.org/uniprot/A0A674MLF9 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/31033:LOC101079229 ^@ http://purl.uniprot.org/uniprot/A0A674NVP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/31033:il15 ^@ http://purl.uniprot.org/uniprot/Q3SCC8|||http://purl.uniprot.org/uniprot/Q3SCC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/31033:cct2 ^@ http://purl.uniprot.org/uniprot/H2RTX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/31033:six3 ^@ http://purl.uniprot.org/uniprot/H2T103 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:gpr1 ^@ http://purl.uniprot.org/uniprot/H2V5Z4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/31033:nkiras2 ^@ http://purl.uniprot.org/uniprot/A0A674MTI8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/31033:ut-c ^@ http://purl.uniprot.org/uniprot/Q5W8V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urea transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:yrdc ^@ http://purl.uniprot.org/uniprot/A0A674NZ18 ^@ Similarity ^@ Belongs to the SUA5 family. http://togogenome.org/gene/31033:LOC101062878 ^@ http://purl.uniprot.org/uniprot/H2SIP9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:terf1 ^@ http://purl.uniprot.org/uniprot/H2U488 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.|||Homodimer.|||Nucleus http://togogenome.org/gene/31033:mrpl19 ^@ http://purl.uniprot.org/uniprot/H2T062 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family. http://togogenome.org/gene/31033:patl1 ^@ http://purl.uniprot.org/uniprot/H2RNJ3|||http://purl.uniprot.org/uniprot/H2RNJ4 ^@ Similarity ^@ Belongs to the PAT1 family. http://togogenome.org/gene/31033:cftr ^@ http://purl.uniprot.org/uniprot/Q9I8E2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.|||Cell membrane|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.|||Membrane|||Recycling endosome membrane http://togogenome.org/gene/31033:cyhr1 ^@ http://purl.uniprot.org/uniprot/H2UAT3 ^@ Similarity ^@ Belongs to the ZFTRAF1 family. http://togogenome.org/gene/31033:dohh ^@ http://purl.uniprot.org/uniprot/H2T0E0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the deoxyhypusine hydroxylase family.|||Binds 2 Fe(2+) ions per subunit.|||Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. http://togogenome.org/gene/31033:ikbke ^@ http://purl.uniprot.org/uniprot/A0A674NVT1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:LOC101076986 ^@ http://purl.uniprot.org/uniprot/H2UZE9 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/31033:plk4 ^@ http://purl.uniprot.org/uniprot/H2T1P6 ^@ Subcellular Location Annotation ^@ centriole http://togogenome.org/gene/31033:LOC446029 ^@ http://purl.uniprot.org/uniprot/H2S970 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/31033:kri1 ^@ http://purl.uniprot.org/uniprot/A0A674NWF7 ^@ Similarity ^@ Belongs to the KRI1 family. http://togogenome.org/gene/31033:LOC101077676 ^@ http://purl.uniprot.org/uniprot/A0A674PG78 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:phlda2 ^@ http://purl.uniprot.org/uniprot/H2TC08 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:LOC101065275 ^@ http://purl.uniprot.org/uniprot/A0A674PR57 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||Membrane|||Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group. http://togogenome.org/gene/31033:ssbp1 ^@ http://purl.uniprot.org/uniprot/H2U9B8 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/31033:myd88 ^@ http://purl.uniprot.org/uniprot/A8QMS7 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.|||Cytoplasm|||The intermediate domain (ID) is required for the phosphorylation and activation of IRAK. http://togogenome.org/gene/31033:kcnj3 ^@ http://purl.uniprot.org/uniprot/H2T1X0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.|||Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.|||Membrane|||This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. http://togogenome.org/gene/31033:lyplal1 ^@ http://purl.uniprot.org/uniprot/A0A674NF37 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/31033:LOC101065757 ^@ http://purl.uniprot.org/uniprot/H2UJA5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:runx2 ^@ http://purl.uniprot.org/uniprot/Q8JFD4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:txnrd2 ^@ http://purl.uniprot.org/uniprot/H2UF24 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/31033:eci1 ^@ http://purl.uniprot.org/uniprot/H2UJG4 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/31033:LOC101075028 ^@ http://purl.uniprot.org/uniprot/H2UZH8 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/31033:LOC101077259 ^@ http://purl.uniprot.org/uniprot/H2S6P5 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/31033:sdad1 ^@ http://purl.uniprot.org/uniprot/H2UBV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDA1 family.|||Required for 60S pre-ribosomal subunits export to the cytoplasm.|||nucleolus http://togogenome.org/gene/31033:LOC101071466 ^@ http://purl.uniprot.org/uniprot/A0A674N8K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Orai family.|||Membrane http://togogenome.org/gene/31033:LOC101072310 ^@ http://purl.uniprot.org/uniprot/A0A674NGP6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/31033:LOC101065589 ^@ http://purl.uniprot.org/uniprot/H2SEX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/31033:abcb10 ^@ http://purl.uniprot.org/uniprot/H2T6Q7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:gria1 ^@ http://purl.uniprot.org/uniprot/A0A674MT32|||http://purl.uniprot.org/uniprot/A0A674NB68 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:kpna6 ^@ http://purl.uniprot.org/uniprot/H2TLL4 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/31033:thbs3 ^@ http://purl.uniprot.org/uniprot/A0A3B5K0J4 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:borcs8 ^@ http://purl.uniprot.org/uniprot/A0A3B5K6L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS8 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/31033:LOC101063989 ^@ http://purl.uniprot.org/uniprot/H2RWU2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/31033:LOC101065324 ^@ http://purl.uniprot.org/uniprot/A0A674MRY9 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/31033:ppara1 ^@ http://purl.uniprot.org/uniprot/A4PE11|||http://purl.uniprot.org/uniprot/H2UYP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/31033:LOC101066651 ^@ http://purl.uniprot.org/uniprot/H2SNJ2|||http://purl.uniprot.org/uniprot/H2SNJ3|||http://purl.uniprot.org/uniprot/H2SNJ4|||http://purl.uniprot.org/uniprot/H2V7J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin 150 kDa subunit family.|||cell cortex|||cytoskeleton http://togogenome.org/gene/31033:psmd7 ^@ http://purl.uniprot.org/uniprot/A0A3B5KP29 ^@ Similarity ^@ Belongs to the peptidase M67A family. http://togogenome.org/gene/31033:ppp4r3a ^@ http://purl.uniprot.org/uniprot/A0A674MEV7 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/31033:tmem39a ^@ http://purl.uniprot.org/uniprot/H2V3T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/31033:LOC619285 ^@ http://purl.uniprot.org/uniprot/Q9I9R2 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Contains one covalently linked retinal chromophore.|||Membrane|||photoreceptor outer segment http://togogenome.org/gene/31033:mc1r ^@ http://purl.uniprot.org/uniprot/Q7ZSY9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. http://togogenome.org/gene/31033:myb ^@ http://purl.uniprot.org/uniprot/A0A674NRY4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:polr1c ^@ http://purl.uniprot.org/uniprot/A0A674NCA1 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/31033:slc10a1 ^@ http://purl.uniprot.org/uniprot/H2UL33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/31033:pde7b ^@ http://purl.uniprot.org/uniprot/A0A3B5K6V0|||http://purl.uniprot.org/uniprot/H2UVS1 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/31033:ube2h ^@ http://purl.uniprot.org/uniprot/H2UW20 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/31033:cltrn ^@ http://purl.uniprot.org/uniprot/H2U8B9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101068145 ^@ http://purl.uniprot.org/uniprot/A0A674P4Q0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Membrane|||Midbody|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. http://togogenome.org/gene/31033:lamtor1 ^@ http://purl.uniprot.org/uniprot/A0A3B5K3P4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/31033:LOC101073522 ^@ http://purl.uniprot.org/uniprot/A0A674NEF8|||http://purl.uniprot.org/uniprot/A0A674PPQ0 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/31033:il8 ^@ http://purl.uniprot.org/uniprot/Q6F4N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/31033:LOC101074686 ^@ http://purl.uniprot.org/uniprot/Q5H719 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/31033:LOC101066282 ^@ http://purl.uniprot.org/uniprot/H2TR44 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/31033:LOC101068717 ^@ http://purl.uniprot.org/uniprot/A0A3B5KIQ6 ^@ Similarity ^@ Belongs to the VHL family. http://togogenome.org/gene/31033:LOC101064256 ^@ http://purl.uniprot.org/uniprot/A0A3B5K5U7 ^@ Similarity ^@ Belongs to the SLBP family. http://togogenome.org/gene/31033:LOC101061342 ^@ http://purl.uniprot.org/uniprot/H2TGH4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:tyw3 ^@ http://purl.uniprot.org/uniprot/A0A3B5KD86 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. http://togogenome.org/gene/31033:ak1 ^@ http://purl.uniprot.org/uniprot/H2SWI8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK1 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer. http://togogenome.org/gene/31033:fgf6 ^@ http://purl.uniprot.org/uniprot/H2TMB1 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/31033:LOC101075977 ^@ http://purl.uniprot.org/uniprot/H2SZZ2 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/31033:tmem38a ^@ http://purl.uniprot.org/uniprot/H2SXH9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/31033:LOC101061224 ^@ http://purl.uniprot.org/uniprot/A0A674PDV4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:LOC101069446 ^@ http://purl.uniprot.org/uniprot/H2UKI9 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/31033:uba52 ^@ http://purl.uniprot.org/uniprot/H2SBM2 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Nucleus http://togogenome.org/gene/31033:nfu1 ^@ http://purl.uniprot.org/uniprot/H2RSB5 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/31033:kdm3b ^@ http://purl.uniprot.org/uniprot/H2RPL3 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM2 histone demethylase family.|||Binds 1 Fe(2+) ion per subunit.|||Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.|||Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.|||Nucleus|||The JmjC domain and the C6-type zinc-finger are required for the demethylation activity. http://togogenome.org/gene/31033:vps52 ^@ http://purl.uniprot.org/uniprot/H2UBE8 ^@ Similarity ^@ Belongs to the VPS52 family. http://togogenome.org/gene/31033:LOC101070134 ^@ http://purl.uniprot.org/uniprot/A0A3B5K686 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/31033:LOC101067444 ^@ http://purl.uniprot.org/uniprot/H2SNX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM54 family.|||Membrane http://togogenome.org/gene/31033:LOC101074968 ^@ http://purl.uniprot.org/uniprot/A0A674N0H8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Golgi apparatus|||Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.|||clathrin-coated vesicle membrane http://togogenome.org/gene/31033:dok7 ^@ http://purl.uniprot.org/uniprot/Q18PD9 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Cell membrane|||Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes (By similarity).|||Synapse|||The PH domain mediated binding to phospholipids with phosphoinositol headgroups. Affinity is highest for phosphatidyl 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate (By similarity). http://togogenome.org/gene/31033:LOC101068125 ^@ http://purl.uniprot.org/uniprot/A0A674PE30 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:LOC101062351 ^@ http://purl.uniprot.org/uniprot/H2U6H2 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:vdac3 ^@ http://purl.uniprot.org/uniprot/A0A674NVG0 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/31033:nell2 ^@ http://purl.uniprot.org/uniprot/A0A674NFJ9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:gdnf ^@ http://purl.uniprot.org/uniprot/H2UC25 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Homodimer; disulfide-linked.|||Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.|||Secreted http://togogenome.org/gene/31033:LOC101061645 ^@ http://purl.uniprot.org/uniprot/H2TDB1 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/31033:raldh3 ^@ http://purl.uniprot.org/uniprot/C1PGW5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/31033:LOC101062249 ^@ http://purl.uniprot.org/uniprot/H2U3P8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:hira ^@ http://purl.uniprot.org/uniprot/O42611 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat HIR1 family.|||Nucleus|||Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle. http://togogenome.org/gene/31033:tmco1 ^@ http://purl.uniprot.org/uniprot/A0A674MH78 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMCO1 family.|||Calcium-selective channel required to prevent calcium stores from overfilling.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:LOC101074285 ^@ http://purl.uniprot.org/uniprot/A0A3B5K6I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:mettl14 ^@ http://purl.uniprot.org/uniprot/H2RLC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MT-A70-like family.|||Heterodimer; heterodimerizes with mettl3 to form an antiparallel heterodimer that constitutes an active methyltransferase.|||Nucleus|||The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with mettl3, mettl14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. http://togogenome.org/gene/31033:LOC101078446 ^@ http://purl.uniprot.org/uniprot/H2TCV9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit C family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm http://togogenome.org/gene/31033:apoc2 ^@ http://purl.uniprot.org/uniprot/Q5KSU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C2 family.|||Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.|||Secreted http://togogenome.org/gene/31033:LOC101073618 ^@ http://purl.uniprot.org/uniprot/A0A3B5KGF8 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/31033:cmtm3 ^@ http://purl.uniprot.org/uniprot/H2V4Q1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:plxna4 ^@ http://purl.uniprot.org/uniprot/A0A674PRM1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:dnm2 ^@ http://purl.uniprot.org/uniprot/H2UBF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.|||Cytoplasm http://togogenome.org/gene/31033:tfdp1 ^@ http://purl.uniprot.org/uniprot/H2U8K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/31033:mrps10 ^@ http://purl.uniprot.org/uniprot/H2TC03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS10 family.|||Mitochondrion http://togogenome.org/gene/31033:pigl ^@ http://purl.uniprot.org/uniprot/H2RNB7 ^@ Function|||Similarity ^@ Belongs to the PIGL family.|||Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol. http://togogenome.org/gene/31033:bsx ^@ http://purl.uniprot.org/uniprot/A0A674N5P6 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:rprd1a ^@ http://purl.uniprot.org/uniprot/H2UH76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.|||Nucleus http://togogenome.org/gene/31033:gbx1 ^@ http://purl.uniprot.org/uniprot/H2SL54 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101076764 ^@ http://purl.uniprot.org/uniprot/A0A674NHD8 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/31033:rtraf ^@ http://purl.uniprot.org/uniprot/A0A3B5K9T5 ^@ Similarity ^@ Belongs to the RTRAF family. http://togogenome.org/gene/31033:LOC101074452 ^@ http://purl.uniprot.org/uniprot/A0A674NX12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/31033:LOC101066901 ^@ http://purl.uniprot.org/uniprot/H2T6V3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-alpha family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. http://togogenome.org/gene/31033:LOC101073544 ^@ http://purl.uniprot.org/uniprot/H2TSB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus|||Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation.|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:c8h20orf27 ^@ http://purl.uniprot.org/uniprot/A0A3B5KGQ3 ^@ Similarity ^@ Belongs to the ADISSP family. http://togogenome.org/gene/31033:sub1 ^@ http://purl.uniprot.org/uniprot/A0A674MYM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transcriptional coactivator PC4 family.|||General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).|||Nucleus http://togogenome.org/gene/31033:rgmb ^@ http://purl.uniprot.org/uniprot/A0A674NSI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:mkrn2 ^@ http://purl.uniprot.org/uniprot/Q5NU13 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Although the makorin-type Cys-His region lacks the final His residue, the following Asp residue may be able to coordinate Zn(2+).|||Cytoplasm|||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Inhibits neurogenesis and axis formation during embryonic development by modulating the phosphatidylinositol 3-kinase (PI3K) pathway. Acts downstream of PI3K and akt1 to up-regulate gsk3b mRNA expression.|||Nucleus http://togogenome.org/gene/31033:LOC101079249 ^@ http://purl.uniprot.org/uniprot/A0A674MD34 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/31033:LOC101071975 ^@ http://purl.uniprot.org/uniprot/A0A674PRS7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. http://togogenome.org/gene/31033:c8h4orf48 ^@ http://purl.uniprot.org/uniprot/H2SIK4 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/31033:rngtt ^@ http://purl.uniprot.org/uniprot/A0A674PMV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.|||In the C-terminal section; belongs to the eukaryotic GTase family.|||In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.|||Nucleus http://togogenome.org/gene/31033:LOC101071148 ^@ http://purl.uniprot.org/uniprot/H2T2U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/31033:tlr21 ^@ http://purl.uniprot.org/uniprot/Q5H724 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/31033:LOC101064314 ^@ http://purl.uniprot.org/uniprot/A0A674N5T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/31033:oip5 ^@ http://purl.uniprot.org/uniprot/A0A3B5KA07 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.|||centromere http://togogenome.org/gene/31033:fam91a1 ^@ http://purl.uniprot.org/uniprot/H2T3S3 ^@ Similarity ^@ Belongs to the FAM91 family. http://togogenome.org/gene/31033:svbp ^@ http://purl.uniprot.org/uniprot/A0A674MLI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVBP family.|||Secreted|||cytoskeleton http://togogenome.org/gene/31033:dph5 ^@ http://purl.uniprot.org/uniprot/A0A674MF64 ^@ Function|||Similarity ^@ Belongs to the diphthine synthase family.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/31033:aff4 ^@ http://purl.uniprot.org/uniprot/A0A674NTE1|||http://purl.uniprot.org/uniprot/H2T674 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/31033:LOC101074868 ^@ http://purl.uniprot.org/uniprot/A0A3B5KD16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:pus7 ^@ http://purl.uniprot.org/uniprot/A0A3B5KQM1 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/31033:LOC101075537 ^@ http://purl.uniprot.org/uniprot/H2V3H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:slc25a32 ^@ http://purl.uniprot.org/uniprot/A0A3B5KBI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:gpr155b ^@ http://purl.uniprot.org/uniprot/Q1KKR1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC100049641 ^@ http://purl.uniprot.org/uniprot/A1KZS7|||http://purl.uniprot.org/uniprot/H2SG59 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Endosome|||Heterooligomeric complex.|||Membrane http://togogenome.org/gene/31033:vkorc1 ^@ http://purl.uniprot.org/uniprot/Q6TEK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VKOR family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:LOC101077745 ^@ http://purl.uniprot.org/uniprot/H2RZ53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/31033:eef1g ^@ http://purl.uniprot.org/uniprot/A0A674P589 ^@ Function|||Subunit ^@ EF-1 is composed of four subunits: alpha, beta, delta, and gamma.|||Probably plays a role in anchoring the complex to other cellular components. http://togogenome.org/gene/31033:hoxc13 ^@ http://purl.uniprot.org/uniprot/Q1KKV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101077477 ^@ http://purl.uniprot.org/uniprot/A0A674MRM1 ^@ Similarity ^@ Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family. http://togogenome.org/gene/31033:ddost ^@ http://purl.uniprot.org/uniprot/H2S8C7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DDOST 48 kDa subunit family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). http://togogenome.org/gene/31033:laptm4b ^@ http://purl.uniprot.org/uniprot/H2TQ71 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/31033:LOC101070482 ^@ http://purl.uniprot.org/uniprot/A0A674NQZ0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:LOC101061207 ^@ http://purl.uniprot.org/uniprot/H2UM56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/31033:LOC101074529 ^@ http://purl.uniprot.org/uniprot/A0A3B5KGH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/31033:LOC101075877 ^@ http://purl.uniprot.org/uniprot/H2S3P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.|||Membrane http://togogenome.org/gene/31033:LOC101068797 ^@ http://purl.uniprot.org/uniprot/A0A674MRV7 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101079664 ^@ http://purl.uniprot.org/uniprot/H2ULZ9 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/31033:slc6a17 ^@ http://purl.uniprot.org/uniprot/H2S489 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/31033:ccdc93 ^@ http://purl.uniprot.org/uniprot/H2UGP8 ^@ Similarity ^@ Belongs to the CCDC93 family. http://togogenome.org/gene/31033:LOC101065477 ^@ http://purl.uniprot.org/uniprot/A0A3B5KHB5 ^@ Similarity ^@ Belongs to the SPSB family. http://togogenome.org/gene/31033:slc35e3 ^@ http://purl.uniprot.org/uniprot/H2T358 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101073582 ^@ http://purl.uniprot.org/uniprot/H2T759 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/31033:LOC100653420 ^@ http://purl.uniprot.org/uniprot/E9LZ01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/31033:neurod2 ^@ http://purl.uniprot.org/uniprot/H2UX28 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:acaa2 ^@ http://purl.uniprot.org/uniprot/H2UYK5 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/31033:midn ^@ http://purl.uniprot.org/uniprot/A0A3B5K4J6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101069249 ^@ http://purl.uniprot.org/uniprot/A0A3B5K6I0 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. http://togogenome.org/gene/31033:hnf1b ^@ http://purl.uniprot.org/uniprot/A0A674MAE3|||http://purl.uniprot.org/uniprot/A0A674NTJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HNF1 homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:czib ^@ http://purl.uniprot.org/uniprot/H2U613 ^@ Similarity ^@ Belongs to the UPF0587 family. http://togogenome.org/gene/31033:plekha8 ^@ http://purl.uniprot.org/uniprot/A0A674PEL3 ^@ Subcellular Location Annotation ^@ trans-Golgi network membrane http://togogenome.org/gene/31033:LOC101070200 ^@ http://purl.uniprot.org/uniprot/A0A3B5KGG5 ^@ Similarity ^@ Belongs to the FAM131 family. http://togogenome.org/gene/31033:clcn3 ^@ http://purl.uniprot.org/uniprot/A0A674P3I0|||http://purl.uniprot.org/uniprot/A0A674P7R8|||http://purl.uniprot.org/uniprot/H2S682 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.|||Cell membrane|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/31033:LOC101063149 ^@ http://purl.uniprot.org/uniprot/A0A3B5KKX7 ^@ Similarity ^@ Belongs to the PDE6D/unc-119 family. http://togogenome.org/gene/31033:spon2 ^@ http://purl.uniprot.org/uniprot/H2UPX8 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/31033:rln3b ^@ http://purl.uniprot.org/uniprot/Q0GY48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/31033:c21h2orf68 ^@ http://purl.uniprot.org/uniprot/H2TV01 ^@ Similarity ^@ Belongs to the UPF0561 family. http://togogenome.org/gene/31033:slc1a4 ^@ http://purl.uniprot.org/uniprot/H2SMU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/31033:LOC101077988 ^@ http://purl.uniprot.org/uniprot/H2S845 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. http://togogenome.org/gene/31033:osbpl8 ^@ http://purl.uniprot.org/uniprot/A0A674PM67 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/31033:LOC101062194 ^@ http://purl.uniprot.org/uniprot/H2UJF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:mdm2 ^@ http://purl.uniprot.org/uniprot/H2T886 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Nucleus http://togogenome.org/gene/31033:ppil6 ^@ http://purl.uniprot.org/uniprot/H2TCH8 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/31033:LOC619283 ^@ http://purl.uniprot.org/uniprot/H2THY3|||http://purl.uniprot.org/uniprot/Q3LU31 ^@ Similarity ^@ Belongs to the synuclein family. http://togogenome.org/gene/31033:fut11 ^@ http://purl.uniprot.org/uniprot/Q70AG8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Probable fucosyltransferase. http://togogenome.org/gene/31033:bloc1s6 ^@ http://purl.uniprot.org/uniprot/A0A3B5KAV5 ^@ Function|||Similarity ^@ Belongs to the BLOC1S6 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. http://togogenome.org/gene/31033:LOC101078843 ^@ http://purl.uniprot.org/uniprot/H2UP80 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:sox4 ^@ http://purl.uniprot.org/uniprot/Q6WNT3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101065606 ^@ http://purl.uniprot.org/uniprot/A0A674MJ48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/31033:LOC101070735 ^@ http://purl.uniprot.org/uniprot/Q1KKR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Deformed subfamily.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:pea15 ^@ http://purl.uniprot.org/uniprot/H2SKB5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:zc3h12b ^@ http://purl.uniprot.org/uniprot/H2U1P2 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/31033:tmbim6 ^@ http://purl.uniprot.org/uniprot/H2RLE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/31033:tp73 ^@ http://purl.uniprot.org/uniprot/A0A674N153 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:stn1 ^@ http://purl.uniprot.org/uniprot/H2TIM5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.|||Component of the CST complex.|||Nucleus|||telomere http://togogenome.org/gene/31033:itpr2 ^@ http://purl.uniprot.org/uniprot/H2SPX2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the InsP3 receptor family.|||Endoplasmic reticulum membrane|||Homotetramer.|||Membrane|||Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.|||The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. http://togogenome.org/gene/31033:txnip ^@ http://purl.uniprot.org/uniprot/H2S6I9 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/31033:LOC101071345 ^@ http://purl.uniprot.org/uniprot/Q69A05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:ndufa2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KM42 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:LOC101063301 ^@ http://purl.uniprot.org/uniprot/A0A3B5JV90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:LOC101066503 ^@ http://purl.uniprot.org/uniprot/A0A674NW16 ^@ Similarity ^@ Belongs to the calcitonin family. http://togogenome.org/gene/31033:memo1 ^@ http://purl.uniprot.org/uniprot/A0A674MA87 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/31033:glis2 ^@ http://purl.uniprot.org/uniprot/H2SRR9 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/31033:LOC101076679 ^@ http://purl.uniprot.org/uniprot/A0A3B5K4G4 ^@ Similarity ^@ Belongs to the RRM TRSPAP family. http://togogenome.org/gene/31033:alkbh8 ^@ http://purl.uniprot.org/uniprot/H2SXL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alkB family.|||Cytoplasm http://togogenome.org/gene/31033:apoe1 ^@ http://purl.uniprot.org/uniprot/Q5KST9 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/31033:timm21 ^@ http://purl.uniprot.org/uniprot/H2TNP6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM21 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/31033:phf5a ^@ http://purl.uniprot.org/uniprot/A0A674P341 ^@ Similarity ^@ Belongs to the PHF5 family. http://togogenome.org/gene/31033:LOC101064355 ^@ http://purl.uniprot.org/uniprot/A0A3B5K855 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/31033:mcee ^@ http://purl.uniprot.org/uniprot/A0A674NQA2 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/31033:mrpl53 ^@ http://purl.uniprot.org/uniprot/H2UKG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL53 family.|||Mitochondrion http://togogenome.org/gene/31033:rps7 ^@ http://purl.uniprot.org/uniprot/P50894 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS7 family.|||Component of the small ribosomal subunit.|||Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for rRNA maturation.|||Cytoplasm|||Nucleus|||centrosome http://togogenome.org/gene/31033:mrpl4 ^@ http://purl.uniprot.org/uniprot/H2T9P2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/31033:LOC101072102 ^@ http://purl.uniprot.org/uniprot/Q1KKY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:ptk2b ^@ http://purl.uniprot.org/uniprot/H2T8Q7 ^@ Subcellular Location Annotation ^@ Cell membrane|||focal adhesion http://togogenome.org/gene/31033:cplx4 ^@ http://purl.uniprot.org/uniprot/A0A3B5K9R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/31033:pcmtd1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KG40 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/31033:atp8b1 ^@ http://purl.uniprot.org/uniprot/A0A674MCK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/31033:LOC101066365 ^@ http://purl.uniprot.org/uniprot/H2RP75 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/31033:LOC101074740 ^@ http://purl.uniprot.org/uniprot/H2UNR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/31033:cul5 ^@ http://purl.uniprot.org/uniprot/A0A6D2Y487 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/31033:fahd1 ^@ http://purl.uniprot.org/uniprot/H2SRW8 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/31033:LOC445899 ^@ http://purl.uniprot.org/uniprot/Q8QGU8 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/31033:LOC101072457 ^@ http://purl.uniprot.org/uniprot/A0A3B5JVF5 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/31033:c1qbp ^@ http://purl.uniprot.org/uniprot/A0A674PBX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAM33 family.|||Cell membrane http://togogenome.org/gene/31033:nr2e1 ^@ http://purl.uniprot.org/uniprot/Q8JHW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/31033:ipo11 ^@ http://purl.uniprot.org/uniprot/A0A3B5KBN2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:LOC101069360 ^@ http://purl.uniprot.org/uniprot/A0A3B5JYS8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/31033:LOC101062076 ^@ http://purl.uniprot.org/uniprot/P53480 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.|||Belongs to the actin family.|||In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.|||Monomethylation at Lys-86 (K86me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.|||N-terminal cleavage of acetylated cysteine of intermediate muscle actin by ACTMAP.|||Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.|||Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.|||Predominantly expressed in heart. Lower levels in skeletal muscle and skin.|||There are three genes coding for cardiac actin in Fugu.|||cytoskeleton http://togogenome.org/gene/31033:LOC101071451 ^@ http://purl.uniprot.org/uniprot/H2TVT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:igfbp4 ^@ http://purl.uniprot.org/uniprot/B6RNJ3 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds IGF2 more than IGF1.|||IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/31033:LOC101069389 ^@ http://purl.uniprot.org/uniprot/A0A3B5KI94|||http://purl.uniprot.org/uniprot/H2S547 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/31033:LOC101071414 ^@ http://purl.uniprot.org/uniprot/H2TSM8 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/31033:rnft2 ^@ http://purl.uniprot.org/uniprot/H2UYB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:taf6l ^@ http://purl.uniprot.org/uniprot/H2U5H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF6 family.|||Nucleus http://togogenome.org/gene/31033:ppp2ca ^@ http://purl.uniprot.org/uniprot/H2T5N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101069675 ^@ http://purl.uniprot.org/uniprot/A0A674NFH6 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/31033:upf2 ^@ http://purl.uniprot.org/uniprot/H2T1T5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:rps2 ^@ http://purl.uniprot.org/uniprot/H2SWH7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/31033:ormdl2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KAT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/31033:gpm6b ^@ http://purl.uniprot.org/uniprot/H2TBY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/31033:ezh1 ^@ http://purl.uniprot.org/uniprot/H2UN44 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:med11 ^@ http://purl.uniprot.org/uniprot/A0A3B5KBV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 11 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/31033:arl1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KDV4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/31033:LOC101073700 ^@ http://purl.uniprot.org/uniprot/A0A3B5KPM5 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/31033:tmem231 ^@ http://purl.uniprot.org/uniprot/A0A3B5KIZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM231 family.|||Membrane|||Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.|||cilium membrane http://togogenome.org/gene/31033:efnb1 ^@ http://purl.uniprot.org/uniprot/A0A674MRV3 ^@ Caution|||Similarity ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101068592 ^@ http://purl.uniprot.org/uniprot/A0A3B5KDY6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101061076 ^@ http://purl.uniprot.org/uniprot/A0A674NTF3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101069811 ^@ http://purl.uniprot.org/uniprot/A0A3B5KF80 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/31033:LOC101077993 ^@ http://purl.uniprot.org/uniprot/H2SNP7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space http://togogenome.org/gene/31033:LOC101064326 ^@ http://purl.uniprot.org/uniprot/H2UET2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYRI family.|||Membrane http://togogenome.org/gene/31033:elovl6 ^@ http://purl.uniprot.org/uniprot/A0A674P5X7 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL6 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-Glycosylated.|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/31033:pllp ^@ http://purl.uniprot.org/uniprot/H2T7G6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:prkci ^@ http://purl.uniprot.org/uniprot/H2SM61 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. http://togogenome.org/gene/31033:LOC105418057 ^@ http://purl.uniprot.org/uniprot/A0A674NTF1 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/31033:adam23 ^@ http://purl.uniprot.org/uniprot/A0A674N1M2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101067706 ^@ http://purl.uniprot.org/uniprot/A0A674MYY5 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/31033:mfsd1 ^@ http://purl.uniprot.org/uniprot/H2SAM5|||http://purl.uniprot.org/uniprot/H2SAM7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:kcmf1 ^@ http://purl.uniprot.org/uniprot/H2RP51 ^@ Function|||Similarity ^@ Belongs to the KCMF1 family.|||Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination. http://togogenome.org/gene/31033:ppil4 ^@ http://purl.uniprot.org/uniprot/H2SVG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/31033:ppm1g ^@ http://purl.uniprot.org/uniprot/H2SU25 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/31033:LOC101069157 ^@ http://purl.uniprot.org/uniprot/A0A3B5KBK5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/31033:LOC101065694 ^@ http://purl.uniprot.org/uniprot/A0A3B5KG77 ^@ Similarity ^@ Belongs to the PROTOR family. http://togogenome.org/gene/31033:tspan31 ^@ http://purl.uniprot.org/uniprot/H2RKJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/31033:papss1 ^@ http://purl.uniprot.org/uniprot/H2T595 ^@ Similarity ^@ In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family. http://togogenome.org/gene/31033:LOC101067566 ^@ http://purl.uniprot.org/uniprot/A0A674MFK4|||http://purl.uniprot.org/uniprot/A0A674NWU8 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/31033:LOC101063134 ^@ http://purl.uniprot.org/uniprot/A0A674PPC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLPTM1 family.|||Membrane http://togogenome.org/gene/31033:psma5 ^@ http://purl.uniprot.org/uniprot/A0A674NQV3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/31033:aspa ^@ http://purl.uniprot.org/uniprot/H2RVG4 ^@ Cofactor|||Similarity ^@ Belongs to the AspA/AstE family. Aspartoacylase subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/31033:LOC101074489 ^@ http://purl.uniprot.org/uniprot/H2T3W8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:LOC101077902 ^@ http://purl.uniprot.org/uniprot/H2USD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/31033:LOC101074561 ^@ http://purl.uniprot.org/uniprot/A0A3B5JXG8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/31033:ccnb3 ^@ http://purl.uniprot.org/uniprot/H2SMD5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. http://togogenome.org/gene/31033:LOC101079325 ^@ http://purl.uniprot.org/uniprot/H2UTT7 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/31033:ube2b ^@ http://purl.uniprot.org/uniprot/A0A674MAI0 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/31033:gpbp1l1 ^@ http://purl.uniprot.org/uniprot/H2U1I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/31033:nol12 ^@ http://purl.uniprot.org/uniprot/A0A674MUB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP17 family.|||nucleolus http://togogenome.org/gene/31033:LOC105416219 ^@ http://purl.uniprot.org/uniprot/H2SF09 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:rps6 ^@ http://purl.uniprot.org/uniprot/A0A3B5KDW2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/31033:LOC101062302 ^@ http://purl.uniprot.org/uniprot/H2T4G9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/31033:fam20c3 ^@ http://purl.uniprot.org/uniprot/A0A6D2WBR0 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/31033:atp6v0a1 ^@ http://purl.uniprot.org/uniprot/H2UPV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/31033:fzd6 ^@ http://purl.uniprot.org/uniprot/H2SXD9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/31033:LOC101073513 ^@ http://purl.uniprot.org/uniprot/A0A674PDS0 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/31033:pdlim1 ^@ http://purl.uniprot.org/uniprot/H2V9A0 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/31033:LOC101072218 ^@ http://purl.uniprot.org/uniprot/H2S048 ^@ Similarity ^@ Belongs to the threonine aldolase family. http://togogenome.org/gene/31033:ren ^@ http://purl.uniprot.org/uniprot/Q6IMP1 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/31033:LOC101072922 ^@ http://purl.uniprot.org/uniprot/H2SJJ3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:vps45 ^@ http://purl.uniprot.org/uniprot/A0A3B5K622 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/31033:gatm ^@ http://purl.uniprot.org/uniprot/H2V3R1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the amidinotransferase family.|||Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development.|||Homodimer.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:cd40 ^@ http://purl.uniprot.org/uniprot/B8YI09 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:cercam ^@ http://purl.uniprot.org/uniprot/H2T9Q6 ^@ Similarity ^@ Belongs to the glycosyltransferase 25 family. http://togogenome.org/gene/31033:LOC101079683 ^@ http://purl.uniprot.org/uniprot/A0A674PDQ8 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/31033:tpm4-2 ^@ http://purl.uniprot.org/uniprot/A0A3B5K7L1|||http://purl.uniprot.org/uniprot/Q805C2|||http://purl.uniprot.org/uniprot/Q805C3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/31033:polr3a ^@ http://purl.uniprot.org/uniprot/H2UBT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/31033:LOC101078862 ^@ http://purl.uniprot.org/uniprot/A0A674MYD8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular space http://togogenome.org/gene/31033:pds5a ^@ http://purl.uniprot.org/uniprot/A0A674PLJ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:lsm14b ^@ http://purl.uniprot.org/uniprot/H2RTQ3 ^@ Similarity ^@ Belongs to the LSM14 family. http://togogenome.org/gene/31033:sox2 ^@ http://purl.uniprot.org/uniprot/Q6WNU1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101061085 ^@ http://purl.uniprot.org/uniprot/H2RM13 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/31033:LOC101070126 ^@ http://purl.uniprot.org/uniprot/H2UJ28 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:LOC101078229 ^@ http://purl.uniprot.org/uniprot/B2GVM0|||http://purl.uniprot.org/uniprot/H2S5W6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit beta family.|||Heterodimer of an alpha and a beta chain.|||Involved in gametogenesis and steroidogenesis.|||Secreted http://togogenome.org/gene/31033:LOC101074250 ^@ http://purl.uniprot.org/uniprot/H2SV97 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/31033:ciapin1 ^@ http://purl.uniprot.org/uniprot/H2SIK2 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion intermembrane space|||Monomer. Interacts with NDOR1. Interacts with CHCHD4.|||Nucleus|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/31033:cav2 ^@ http://purl.uniprot.org/uniprot/Q9YGM9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||Homooligomer.|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).|||caveola http://togogenome.org/gene/31033:LOC101069651 ^@ http://purl.uniprot.org/uniprot/H2TQH3 ^@ Function|||Similarity|||Subunit ^@ Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.|||Homotetramer.|||In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.|||In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. http://togogenome.org/gene/31033:st8sia3 ^@ http://purl.uniprot.org/uniprot/Q6KC07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/31033:tpm2 ^@ http://purl.uniprot.org/uniprot/Q805C7|||http://purl.uniprot.org/uniprot/Q805C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/31033:traf4 ^@ http://purl.uniprot.org/uniprot/A0A3B5KJY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/31033:lhx6 ^@ http://purl.uniprot.org/uniprot/H2SPT4 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101077778 ^@ http://purl.uniprot.org/uniprot/A0A3B5KHB2 ^@ Function|||Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition. http://togogenome.org/gene/31033:ntn1 ^@ http://purl.uniprot.org/uniprot/H2U9Y6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:atp6v1a ^@ http://purl.uniprot.org/uniprot/H2RQI3 ^@ Similarity ^@ Belongs to the ATPase alpha/beta chains family. http://togogenome.org/gene/31033:LOC101073954 ^@ http://purl.uniprot.org/uniprot/H2SDK7 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/31033:LOC101078807 ^@ http://purl.uniprot.org/uniprot/H2SFC9 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:ugt1a1 ^@ http://purl.uniprot.org/uniprot/H2T5F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/31033:ndufa11 ^@ http://purl.uniprot.org/uniprot/A0A3B5JW85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I NDUFA11 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:rtn4ip1 ^@ http://purl.uniprot.org/uniprot/H2S8W8 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/31033:vapa ^@ http://purl.uniprot.org/uniprot/A0A3B5K8I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/31033:LOC101068299 ^@ http://purl.uniprot.org/uniprot/A0A674MDY7 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/31033:LOC101068642 ^@ http://purl.uniprot.org/uniprot/L8AZK3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/31033:ell ^@ http://purl.uniprot.org/uniprot/H2V909 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Nucleus http://togogenome.org/gene/31033:sgms2 ^@ http://purl.uniprot.org/uniprot/H2T7F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/31033:dda1 ^@ http://purl.uniprot.org/uniprot/A0A674NQW2 ^@ Similarity ^@ Belongs to the DDA1 family. http://togogenome.org/gene/31033:LOC101067711 ^@ http://purl.uniprot.org/uniprot/Q6E5T0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:LOC101076518 ^@ http://purl.uniprot.org/uniprot/A0A3B5KTB6 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/31033:LOC101070821 ^@ http://purl.uniprot.org/uniprot/H2SPZ0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/31033:LOC101062896 ^@ http://purl.uniprot.org/uniprot/H2U5I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/31033:LOC101069529 ^@ http://purl.uniprot.org/uniprot/A0A674PD11 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/31033:LOC101063521 ^@ http://purl.uniprot.org/uniprot/H2SH61 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/31033:LOC101063003 ^@ http://purl.uniprot.org/uniprot/A0A3B5KI97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.|||Nucleus http://togogenome.org/gene/31033:LOC115246426 ^@ http://purl.uniprot.org/uniprot/A0A3B5KB33 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101079015 ^@ http://purl.uniprot.org/uniprot/H2UDB6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/31033:psmd13 ^@ http://purl.uniprot.org/uniprot/A0A674PII0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S11 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/31033:LOC101069203 ^@ http://purl.uniprot.org/uniprot/H2UTK4 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/31033:LOC101077200 ^@ http://purl.uniprot.org/uniprot/P53480 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.|||Belongs to the actin family.|||In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.|||Monomethylation at Lys-86 (K86me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.|||N-terminal cleavage of acetylated cysteine of intermediate muscle actin by ACTMAP.|||Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.|||Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.|||Predominantly expressed in heart. Lower levels in skeletal muscle and skin.|||There are three genes coding for cardiac actin in Fugu.|||cytoskeleton http://togogenome.org/gene/31033:LOC101064501 ^@ http://purl.uniprot.org/uniprot/H2SUM6 ^@ Similarity ^@ Belongs to the gonadal family. http://togogenome.org/gene/31033:tmem30a ^@ http://purl.uniprot.org/uniprot/H2TK87 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/31033:kcnc1 ^@ http://purl.uniprot.org/uniprot/H2U8E7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101063187 ^@ http://purl.uniprot.org/uniprot/H2V126 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/31033:aox1 ^@ http://purl.uniprot.org/uniprot/M1ZML4 ^@ Cofactor|||Similarity ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters. http://togogenome.org/gene/31033:eif3h ^@ http://purl.uniprot.org/uniprot/H2T115 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit H family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm http://togogenome.org/gene/31033:bri3 ^@ http://purl.uniprot.org/uniprot/A0A674NC06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BRI3 family.|||Membrane|||perinuclear region http://togogenome.org/gene/31033:LOC101072115 ^@ http://purl.uniprot.org/uniprot/A0A674P0E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/31033:pold1 ^@ http://purl.uniprot.org/uniprot/H2SW10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||Nucleus http://togogenome.org/gene/31033:runx3 ^@ http://purl.uniprot.org/uniprot/A0A9P4|||http://purl.uniprot.org/uniprot/Q642Y1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101065877 ^@ http://purl.uniprot.org/uniprot/H2T8Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SH3PXD2 family.|||Cytoplasm http://togogenome.org/gene/31033:tbxas1 ^@ http://purl.uniprot.org/uniprot/H2T1N2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/31033:LOC105416476 ^@ http://purl.uniprot.org/uniprot/A0A674MEW0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Nematocyst|||Target cell membrane http://togogenome.org/gene/31033:LOC101078739 ^@ http://purl.uniprot.org/uniprot/H2UXZ6 ^@ Function|||Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. http://togogenome.org/gene/31033:eef1b2 ^@ http://purl.uniprot.org/uniprot/H2TXT3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the EF-1-beta/EF-1-delta family.|||EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.|||EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. http://togogenome.org/gene/31033:LOC101076743 ^@ http://purl.uniprot.org/uniprot/H2TMA8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/31033:urad ^@ http://purl.uniprot.org/uniprot/H2SNG7 ^@ Function|||Similarity ^@ Belongs to the OHCU decarboxylase family.|||Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin. http://togogenome.org/gene/31033:nsun5 ^@ http://purl.uniprot.org/uniprot/H2V8F8 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/31033:il12a ^@ http://purl.uniprot.org/uniprot/Q7SX81 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-6 superfamily.|||Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.|||Secreted http://togogenome.org/gene/31033:egr3 ^@ http://purl.uniprot.org/uniprot/H2RXQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/31033:LOC101068776 ^@ http://purl.uniprot.org/uniprot/H2TEM6 ^@ Similarity ^@ Belongs to the GST superfamily. Theta family. http://togogenome.org/gene/31033:LOC101072042 ^@ http://purl.uniprot.org/uniprot/H2TQR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.|||Nucleus http://togogenome.org/gene/31033:LOC101067994 ^@ http://purl.uniprot.org/uniprot/A0A674N6C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the band 7/mec-2 family.|||Membrane http://togogenome.org/gene/31033:LOC101066055 ^@ http://purl.uniprot.org/uniprot/H2TPI5 ^@ Similarity ^@ Belongs to the YY transcription factor family. http://togogenome.org/gene/31033:LOC101078868 ^@ http://purl.uniprot.org/uniprot/A0A674NME4 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/31033:LOC101062737 ^@ http://purl.uniprot.org/uniprot/A0A674MP83 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/31033:LOC101062925 ^@ http://purl.uniprot.org/uniprot/H2UJZ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/31033:LOC101065022 ^@ http://purl.uniprot.org/uniprot/H2T241 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/31033:LOC101076921 ^@ http://purl.uniprot.org/uniprot/H2RRP4 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/31033:usp49 ^@ http://purl.uniprot.org/uniprot/H2TC04 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/31033:ugp2 ^@ http://purl.uniprot.org/uniprot/A0A674PDB3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Homooctamer.|||UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. http://togogenome.org/gene/31033:LOC101078241 ^@ http://purl.uniprot.org/uniprot/H2U0P6 ^@ Similarity ^@ Belongs to the ependymin family. http://togogenome.org/gene/31033:vps41 ^@ http://purl.uniprot.org/uniprot/H2T3Z4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS41 family.|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/31033:LOC101064242 ^@ http://purl.uniprot.org/uniprot/A0A6D2W9X6 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/31033:xkr7 ^@ http://purl.uniprot.org/uniprot/Q5GH47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/31033:tm9sf1 ^@ http://purl.uniprot.org/uniprot/H2U5Y5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/31033:taf8 ^@ http://purl.uniprot.org/uniprot/H2TD69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF8 family.|||Nucleus http://togogenome.org/gene/31033:LOC101061942 ^@ http://purl.uniprot.org/uniprot/H2T1L6 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/31033:alkal2 ^@ http://purl.uniprot.org/uniprot/A0A3B5K4D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALKAL family.|||Secreted http://togogenome.org/gene/31033:lancl1 ^@ http://purl.uniprot.org/uniprot/H2TCD3 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/31033:LOC101073369 ^@ http://purl.uniprot.org/uniprot/H2RUG3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/31033:ppp2r3c ^@ http://purl.uniprot.org/uniprot/A0A674NT51 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101078798 ^@ http://purl.uniprot.org/uniprot/A0A674NK27 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGR2 family.|||Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.|||Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.|||Mitochondrion inner membrane http://togogenome.org/gene/31033:LOC101074394 ^@ http://purl.uniprot.org/uniprot/H2TXE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:psmb8 ^@ http://purl.uniprot.org/uniprot/A0A674MQY3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus|||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. http://togogenome.org/gene/31033:LOC101069732 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZ18 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/31033:hpgd ^@ http://purl.uniprot.org/uniprot/A0A3B5K0R0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/31033:arl6ip5 ^@ http://purl.uniprot.org/uniprot/H2U2I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/31033:LOC101072487 ^@ http://purl.uniprot.org/uniprot/H2V2G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/31033:tent5b ^@ http://purl.uniprot.org/uniprot/A0A3B5KEU6 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/31033:itgb8 ^@ http://purl.uniprot.org/uniprot/H2T4I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:LOC101069469 ^@ http://purl.uniprot.org/uniprot/H2SGS8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ May interact with TSPO.|||Mitochondrion|||Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. http://togogenome.org/gene/31033:slc35a5 ^@ http://purl.uniprot.org/uniprot/H2UIG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:abat ^@ http://purl.uniprot.org/uniprot/A0A3B5K9R2 ^@ Similarity|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/31033:unk ^@ http://purl.uniprot.org/uniprot/H2SZ51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unkempt family.|||Cytoplasm http://togogenome.org/gene/31033:znf277 ^@ http://purl.uniprot.org/uniprot/H2UJX1 ^@ Similarity ^@ Belongs to the ZNF277 family. http://togogenome.org/gene/31033:six6 ^@ http://purl.uniprot.org/uniprot/H2TPS1 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101073986 ^@ http://purl.uniprot.org/uniprot/H2U252 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular space http://togogenome.org/gene/31033:LOC101068020 ^@ http://purl.uniprot.org/uniprot/A0A3B5K2X8 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/31033:rbm5 ^@ http://purl.uniprot.org/uniprot/H2T7V2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:LOC101075286 ^@ http://purl.uniprot.org/uniprot/A0A674MRD8|||http://purl.uniprot.org/uniprot/A0A674NHA3|||http://purl.uniprot.org/uniprot/A0A674NU41 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/31033:zc3hc1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KFE6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:slc35e2b ^@ http://purl.uniprot.org/uniprot/A0A3B5KAV4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:elk3 ^@ http://purl.uniprot.org/uniprot/H2V2E8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/31033:LOC101065113 ^@ http://purl.uniprot.org/uniprot/A0A3B5KH02 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:sec22a ^@ http://purl.uniprot.org/uniprot/H2UHI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/31033:tns4 ^@ http://purl.uniprot.org/uniprot/A0A674P595 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/31033:LOC101072935 ^@ http://purl.uniprot.org/uniprot/A0A3B5KPW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCR4/nocturin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:tarbp2 ^@ http://purl.uniprot.org/uniprot/H2UIJ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TARBP2 family.|||Cytoplasm|||Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.|||Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. http://togogenome.org/gene/31033:tada3 ^@ http://purl.uniprot.org/uniprot/H2TRW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGG1 family.|||Nucleus http://togogenome.org/gene/31033:csnk1a1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KVB5|||http://purl.uniprot.org/uniprot/A0A674MKV3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:LOC101073769 ^@ http://purl.uniprot.org/uniprot/H2TA05|||http://purl.uniprot.org/uniprot/H2TA06 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/31033:LOC101070469 ^@ http://purl.uniprot.org/uniprot/H2VDM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/31033:dnal4 ^@ http://purl.uniprot.org/uniprot/A0A674MPH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/31033:bcap29 ^@ http://purl.uniprot.org/uniprot/H2UXB9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.|||Membrane http://togogenome.org/gene/31033:LOC101065558 ^@ http://purl.uniprot.org/uniprot/H2VAE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-alpha family. G(12) subfamily.|||Membrane http://togogenome.org/gene/31033:fgf5 ^@ http://purl.uniprot.org/uniprot/H2RQ78 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/31033:pcnp ^@ http://purl.uniprot.org/uniprot/H2V3U7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with UHRF2/NIRF.|||May be involved in cell cycle regulation.|||Nucleus http://togogenome.org/gene/31033:LOC101069090 ^@ http://purl.uniprot.org/uniprot/A0A674NUN5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:prdx2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KK95 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/31033:ninj1 ^@ http://purl.uniprot.org/uniprot/H2UC52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ninjurin family.|||Membrane http://togogenome.org/gene/31033:polb ^@ http://purl.uniprot.org/uniprot/H2UYD9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Cytoplasm|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/31033:mc5r ^@ http://purl.uniprot.org/uniprot/Q7ZT40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins. http://togogenome.org/gene/31033:LOC101071730 ^@ http://purl.uniprot.org/uniprot/H2UMW1 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/31033:LOC101072236 ^@ http://purl.uniprot.org/uniprot/H2UK16 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. http://togogenome.org/gene/31033:ncaph ^@ http://purl.uniprot.org/uniprot/H2TGH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CND2 (condensin subunit 2) family.|||Chromosome|||Cytoplasm|||Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. http://togogenome.org/gene/31033:cct8 ^@ http://purl.uniprot.org/uniprot/H2V3Z2|||http://purl.uniprot.org/uniprot/H2V3Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||cilium basal body http://togogenome.org/gene/31033:trappc2l ^@ http://purl.uniprot.org/uniprot/H2V4Q7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/31033:spag9 ^@ http://purl.uniprot.org/uniprot/H2S7N4 ^@ Similarity ^@ Belongs to the JIP scaffold family. http://togogenome.org/gene/31033:ppat ^@ http://purl.uniprot.org/uniprot/H2UTF0 ^@ Cofactor|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/31033:LOC101063586 ^@ http://purl.uniprot.org/uniprot/H2SXF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/31033:paqr7 ^@ http://purl.uniprot.org/uniprot/Q19WU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/31033:ppt1 ^@ http://purl.uniprot.org/uniprot/A0A674NCV2 ^@ Similarity ^@ Belongs to the palmitoyl-protein thioesterase family. http://togogenome.org/gene/31033:prkaa1 ^@ http://purl.uniprot.org/uniprot/H2VDB7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/31033:meis2 ^@ http://purl.uniprot.org/uniprot/A0A674NP10 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:egr1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KCH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus|||Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. http://togogenome.org/gene/31033:sgk2 ^@ http://purl.uniprot.org/uniprot/A0A674MMD6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/31033:thg1l ^@ http://purl.uniprot.org/uniprot/H2TIL1 ^@ Cofactor|||Function|||Similarity ^@ Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.|||Belongs to the tRNA(His) guanylyltransferase family.|||Binds 2 magnesium ions per subunit. http://togogenome.org/gene/31033:c6h5orf30 ^@ http://purl.uniprot.org/uniprot/H2SVL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UNC119-binding protein family.|||Cytoplasm|||cilium http://togogenome.org/gene/31033:barx1 ^@ http://purl.uniprot.org/uniprot/H2SHF7 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:ybey ^@ http://purl.uniprot.org/uniprot/A0A674NE25 ^@ Similarity ^@ Belongs to the endoribonuclease YbeY family. http://togogenome.org/gene/31033:tp53inp2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KL89|||http://purl.uniprot.org/uniprot/A0A674N5L2 ^@ Subcellular Location Annotation ^@ PML body|||autophagosome|||cytosol http://togogenome.org/gene/31033:slc25a4 ^@ http://purl.uniprot.org/uniprot/Q5KSP3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/31033:eif2b2 ^@ http://purl.uniprot.org/uniprot/Q90511 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2B alpha/beta/delta subunits family.|||Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.|||Complex of five different subunits; alpha, beta, gamma, delta and epsilon. http://togogenome.org/gene/31033:LOC101074105 ^@ http://purl.uniprot.org/uniprot/H2T390 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/31033:yipf6 ^@ http://purl.uniprot.org/uniprot/A0A674N3R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/31033:erbb3 ^@ http://purl.uniprot.org/uniprot/H2TXM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/31033:rnf20 ^@ http://purl.uniprot.org/uniprot/H2T8F2|||http://purl.uniprot.org/uniprot/H2T8F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BRE1 family.|||Nucleus http://togogenome.org/gene/31033:gnb1 ^@ http://purl.uniprot.org/uniprot/A0A674PKN5 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/31033:LOC101070377 ^@ http://purl.uniprot.org/uniprot/Q6J5K2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane|||Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. http://togogenome.org/gene/31033:LOC101073532 ^@ http://purl.uniprot.org/uniprot/A0A674PPI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/31033:bmpr2 ^@ http://purl.uniprot.org/uniprot/A0A674MIS1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. http://togogenome.org/gene/31033:rock1 ^@ http://purl.uniprot.org/uniprot/H2UA39 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by RHOA binding. Inhibited by Y-27632.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cytoplasm|||Homodimer.|||Membrane|||Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. http://togogenome.org/gene/31033:tbx21 ^@ http://purl.uniprot.org/uniprot/H2U7Q0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/31033:LOC101065621 ^@ http://purl.uniprot.org/uniprot/A0A3B5K6I3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Nucleus|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/31033:galk1 ^@ http://purl.uniprot.org/uniprot/H2T403|||http://purl.uniprot.org/uniprot/H2T406 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/31033:npy8br ^@ http://purl.uniprot.org/uniprot/A7XY87 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:LOC101075961 ^@ http://purl.uniprot.org/uniprot/A0A3B5K1P7 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/31033:LOC101076880 ^@ http://purl.uniprot.org/uniprot/A0A3B5JZ13 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/31033:mrpl27 ^@ http://purl.uniprot.org/uniprot/A0A674NWS5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/31033:hjv ^@ http://purl.uniprot.org/uniprot/H2T9J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:c17h19orf53 ^@ http://purl.uniprot.org/uniprot/A0A674NED8 ^@ Similarity ^@ Belongs to the UPF0390 family. http://togogenome.org/gene/31033:smc3 ^@ http://purl.uniprot.org/uniprot/Q802S0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC3 subfamily.|||Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.|||Nucleus|||centromere http://togogenome.org/gene/31033:borcs5 ^@ http://purl.uniprot.org/uniprot/A0A3B5KKS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS5 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/31033:LOC101077303 ^@ http://purl.uniprot.org/uniprot/H2S0V8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||The PAL motif is required for normal active site conformation. http://togogenome.org/gene/31033:alx3 ^@ http://purl.uniprot.org/uniprot/H2S3V9 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:igsf3 ^@ http://purl.uniprot.org/uniprot/H2TPT2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:fgfbp1 ^@ http://purl.uniprot.org/uniprot/H2SWM7 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/31033:slc16a7 ^@ http://purl.uniprot.org/uniprot/A0A3B5KBP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/31033:arl4c ^@ http://purl.uniprot.org/uniprot/H2S481 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/31033:LOC101077600 ^@ http://purl.uniprot.org/uniprot/A0A3B5K3Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SMU1 family.|||Nucleus speckle http://togogenome.org/gene/31033:LOC101078155 ^@ http://purl.uniprot.org/uniprot/A0A674P329 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/31033:LOC101066771 ^@ http://purl.uniprot.org/uniprot/Q7M570 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/31033:tgfb3 ^@ http://purl.uniprot.org/uniprot/A0A3B5KFF1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.|||extracellular matrix http://togogenome.org/gene/31033:LOC101077955 ^@ http://purl.uniprot.org/uniprot/H2THG6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.|||extracellular matrix http://togogenome.org/gene/31033:sephs1 ^@ http://purl.uniprot.org/uniprot/A0A3B5KKZ8 ^@ Function ^@ Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/31033:usp33 ^@ http://purl.uniprot.org/uniprot/A0A674NUC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family. USP20/USP33 subfamily.|||centrosome|||perinuclear region http://togogenome.org/gene/31033:LOC101061545 ^@ http://purl.uniprot.org/uniprot/A0A674MML4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/31033:LOC101077171 ^@ http://purl.uniprot.org/uniprot/H2U787 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/31033:atp5f1e ^@ http://purl.uniprot.org/uniprot/A0A674P2M6 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ATPase epsilon family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/31033:vti1a ^@ http://purl.uniprot.org/uniprot/A0A3B5KM05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/31033:LOC101071223 ^@ http://purl.uniprot.org/uniprot/H2UWA5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:srrt ^@ http://purl.uniprot.org/uniprot/H2UVX4 ^@ Similarity ^@ Belongs to the ARS2 family. http://togogenome.org/gene/31033:LOC101063355 ^@ http://purl.uniprot.org/uniprot/H2SUC4 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/31033:LOC101062687 ^@ http://purl.uniprot.org/uniprot/A0A3B5K9Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hepcidin family.|||Secreted http://togogenome.org/gene/31033:LOC101079816 ^@ http://purl.uniprot.org/uniprot/H2TP17 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.|||Membrane|||Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.|||sarcolemma http://togogenome.org/gene/31033:LOC101065462 ^@ http://purl.uniprot.org/uniprot/H2S3V3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/31033:LOC101078482 ^@ http://purl.uniprot.org/uniprot/A0A674MQP9 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/31033:c9h11orf58 ^@ http://purl.uniprot.org/uniprot/H2ULF5 ^@ Similarity ^@ Belongs to the SMAP family. http://togogenome.org/gene/31033:p22phox ^@ http://purl.uniprot.org/uniprot/Q7T1Q0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the p22phox family.|||Cell membrane|||Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).|||Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.|||Membrane http://togogenome.org/gene/31033:apex2 ^@ http://purl.uniprot.org/uniprot/H2USW1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/31033:plcb4 ^@ http://purl.uniprot.org/uniprot/H2TF26 ^@ Cofactor|||Function ^@ Binds 1 Ca(2+) ion per subunit.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/31033:LOC101073257 ^@ http://purl.uniprot.org/uniprot/H2SCF7 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/31033:lnpkb ^@ http://purl.uniprot.org/uniprot/Q1KKR9 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lunapark family.|||Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within three-way ER tubular junction network (By similarity).|||Endoplasmic reticulum membrane|||Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.|||Phosphorylated. Phosphorylation occurs during interphase. Phosphorylation occurs also during mitosis; these phosphorylations reduce both its homodimerization and the ER three-way tubular junction formation.|||The transmembrane domain 1 and 2 function as a signal-anchor and stop-transfer sequence, respectively, generating a double-spanning integral membrane protein with a N- and C-terminal cytoplasmic orientation. Transmembrane domain 1 and 2 are probably sufficient to mediate membrane translocation and topology formation in a N-myristoylation-independent manner. Transmembrane domain 2 is sufficient to block the protein secretion pathway. The two coiled-coil domains are necessary for its endoplasmic reticulum (ER) three-way tubular junction localization. The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation. http://togogenome.org/gene/31033:dnm3 ^@ http://purl.uniprot.org/uniprot/H2UYQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.|||Cytoplasm http://togogenome.org/gene/31033:LOC101061817 ^@ http://purl.uniprot.org/uniprot/A0A674MEU8 ^@ Similarity ^@ Belongs to the EEIG family. http://togogenome.org/gene/31033:kdsr ^@ http://purl.uniprot.org/uniprot/A0A674P0N9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/31033:dlx3 ^@ http://purl.uniprot.org/uniprot/H2UZF1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101075923 ^@ http://purl.uniprot.org/uniprot/A0A3B5KBV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/31033:trappc5 ^@ http://purl.uniprot.org/uniprot/A0A3B5KE80 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||Part of the multisubunit TRAPP (transport protein particle) complex.|||cis-Golgi network http://togogenome.org/gene/31033:tbp ^@ http://purl.uniprot.org/uniprot/A6H913 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/31033:amhr2 ^@ http://purl.uniprot.org/uniprot/I0IUI9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. http://togogenome.org/gene/31033:mrto4 ^@ http://purl.uniprot.org/uniprot/A0A674NAQ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the pre-60S ribosomal particle.|||Belongs to the universal ribosomal protein uL10 family.|||Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.|||Cytoplasm|||nucleolus http://togogenome.org/gene/31033:LOC101062006 ^@ http://purl.uniprot.org/uniprot/A0A674MAZ0 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/31033:LOC105416804 ^@ http://purl.uniprot.org/uniprot/Q6E5S1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/31033:KEF89_p11 ^@ http://purl.uniprot.org/uniprot/Q8HCW3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/31033:foxo3 ^@ http://purl.uniprot.org/uniprot/H2RT85 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/31033:paqr3 ^@ http://purl.uniprot.org/uniprot/H2RT57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/31033:il-6 ^@ http://purl.uniprot.org/uniprot/Q6L6X6 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ After induction, highly expressed in spleen. Can also be expressed in kidney after incubation with PHA.|||Belongs to the IL-6 superfamily.|||By LPS and PBS.|||Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST.|||Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.|||Secreted http://togogenome.org/gene/31033:tmeff2 ^@ http://purl.uniprot.org/uniprot/H2S1Z3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/31033:cnp ^@ http://purl.uniprot.org/uniprot/A0A3B5JUU3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 2H phosphoesterase superfamily. CNPase family.|||Exists as monomers and homodimers.|||Melanosome|||Membrane http://togogenome.org/gene/31033:LOC101061594 ^@ http://purl.uniprot.org/uniprot/A0A674NLH7 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Plays an important role in regulating the size of autophagosomes during the formation process. http://togogenome.org/gene/31033:hmx2 ^@ http://purl.uniprot.org/uniprot/H2RR99 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/31033:LOC101079259 ^@ http://purl.uniprot.org/uniprot/A0A674NSP6 ^@ Similarity ^@ Belongs to the PPDPF family. http://togogenome.org/gene/31033:LOC101075588 ^@ http://purl.uniprot.org/uniprot/H2SEU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cell surface|||Endosome|||Membrane http://togogenome.org/gene/31033:gadd45gip1 ^@ http://purl.uniprot.org/uniprot/H2UE61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.|||Belongs to the mitochondrion-specific ribosomal protein mL64 family.|||Mitochondrion|||Nucleus http://togogenome.org/gene/31033:lect2 ^@ http://purl.uniprot.org/uniprot/A0A3B5KVM1 ^@ Similarity ^@ Belongs to the LECT2/MIM-1 family. http://togogenome.org/gene/31033:a3galt2 ^@ http://purl.uniprot.org/uniprot/H2UKJ8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 6 family.|||Binds 1 Mn(2+) ion per subunit.|||Membrane http://togogenome.org/gene/31033:LOC101068230 ^@ http://purl.uniprot.org/uniprot/H2UEE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Nucleus http://togogenome.org/gene/31033:LOC101062700 ^@ http://purl.uniprot.org/uniprot/A0A674P1W7 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/31033:ercc3 ^@ http://purl.uniprot.org/uniprot/A0A3B5K7N7 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/31033:aldh6a1 ^@ http://purl.uniprot.org/uniprot/A0A674P718 ^@ Function|||Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. http://togogenome.org/gene/31033:LOC101070032 ^@ http://purl.uniprot.org/uniprot/A0A674NYF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/31033:med9 ^@ http://purl.uniprot.org/uniprot/A0A674NQZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 9 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/31033:LOC101071141 ^@ http://purl.uniprot.org/uniprot/H2UX76 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/31033:LOC101072579 ^@ http://purl.uniprot.org/uniprot/H2U9V3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/31033:tas1r2b ^@ http://purl.uniprot.org/uniprot/Q2MHJ9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/31033:gpr39 ^@ http://purl.uniprot.org/uniprot/A7UKT2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/31033:tfap2d ^@ http://purl.uniprot.org/uniprot/H2RPI3 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/31033:fbl ^@ http://purl.uniprot.org/uniprot/H2SDJ0 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Fibrillarin family. http://togogenome.org/gene/31033:hoxa1 ^@ http://purl.uniprot.org/uniprot/Q1KL10 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.