http://togogenome.org/gene/319706:G6N46_RS10385 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZMV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. AlkB subfamily.|||Cell inner membrane|||Membrane http://togogenome.org/gene/319706:G6N46_RS06830 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZNR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Membrane http://togogenome.org/gene/319706:G6N46_RS13065 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZQN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0073 (Hly-III) family.|||Membrane http://togogenome.org/gene/319706:G6N46_RS07425 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZKC5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/319706:G6N46_RS19620 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZTB4 ^@ Similarity ^@ Belongs to the AccD/PCCB family. http://togogenome.org/gene/319706:G6N46_RS01465 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZGK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome ubiquinol oxidase subunit 1 family.|||Membrane http://togogenome.org/gene/319706:G6N46_RS26940 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZXI7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the rubredoxin family.|||Binds 1 Fe(3+) ion per subunit.|||Involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase. http://togogenome.org/gene/319706:G6N46_RS15905 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZTR6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/319706:G6N46_RS09760 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZNJ1 ^@ Function|||Similarity ^@ Belongs to the HrcA family.|||Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons. http://togogenome.org/gene/319706:G6N46_RS21390 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZU38 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/319706:G6N46_RS08010 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZKA2 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the prokaryotic ubiquitin-like protein family.|||Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.|||Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.|||The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome. http://togogenome.org/gene/319706:G6N46_RS22140 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZXD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DedA family.|||Cell membrane|||Membrane http://togogenome.org/gene/319706:G6N46_RS16560 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZSV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.|||Cell membrane|||Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. http://togogenome.org/gene/319706:G6N46_RS13105 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZN51 ^@ Similarity|||Subunit ^@ Belongs to the trans-sulfuration enzymes family.|||Homotetramer. http://togogenome.org/gene/319706:G6N46_RS01790 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZHR1 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/319706:G6N46_RS20340 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZWB5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/319706:G6N46_RS08765 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZL33 ^@ Function|||Similarity ^@ Belongs to the CobT family.|||Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). http://togogenome.org/gene/319706:G6N46_RS09395 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZKZ7 ^@ Similarity ^@ Belongs to the MmpS family. http://togogenome.org/gene/319706:G6N46_RS11565 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZRD6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/319706:G6N46_RS04355 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZI66 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/319706:G6N46_RS02640 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZJG3 ^@ Similarity ^@ Belongs to the UPF0749 family. http://togogenome.org/gene/319706:G6N46_RS19135 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZTZ9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/319706:G6N46_RS08725 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZLY6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Membrane|||Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). http://togogenome.org/gene/319706:G6N46_RS17985 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZV05 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/319706:G6N46_RS12035 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZMG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Mediates influx of magnesium ions.|||Membrane http://togogenome.org/gene/319706:G6N46_RS00375 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZFX9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/319706:G6N46_RS24245 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZV89 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/319706:G6N46_RS00305 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZJU4 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/319706:G6N46_RS20850 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZVN3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/319706:G6N46_RS11750 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZPN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/319706:G6N46_RS25685 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZYJ9 ^@ Similarity ^@ Belongs to the MmpS family. http://togogenome.org/gene/319706:G6N46_RS06120 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZKC2 ^@ Function|||Similarity ^@ Belongs to the sigma-70 factor family.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. http://togogenome.org/gene/319706:G6N46_RS17280 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZQF2 ^@ Similarity ^@ Belongs to the CsoR family. http://togogenome.org/gene/319706:G6N46_RS13725 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZR05 ^@ Similarity|||Subunit ^@ Belongs to the sigma-70 factor family. ECF subfamily.|||Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription. http://togogenome.org/gene/319706:G6N46_RS13910 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZPQ0 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/319706:G6N46_RS04455 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZIA7 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/319706:G6N46_RS03025 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZHH1 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/319706:G6N46_RS07765 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZK56 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homodimer or homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/319706:G6N46_RS24220 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZUF9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/319706:G6N46_RS06890 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZME9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/319706:G6N46_RS01785 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZGK6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/319706:G6N46_RS00350 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZJV3 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/319706:G6N46_RS03130 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZHL1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the peroxiredoxin family. Tpx subfamily.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/319706:G6N46_RS08870 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZPW9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glutamine synthetase family.|||Cytoplasm|||Oligomer of 12 subunits arranged in the form of two hexagons. http://togogenome.org/gene/319706:G6N46_RS26790 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZXF5 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/319706:G6N46_RS00365 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZIR0 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/319706:G6N46_RS26820 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZW00 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/319706:G6N46_RS01310 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZJB7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRA-CH family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/319706:G6N46_RS23365 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZTZ7 ^@ Similarity ^@ Belongs to the F420H(2)-dependent quinone reductase family. http://togogenome.org/gene/319706:G6N46_RS11285 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZNF9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNase PH family.|||Homohexameric ring arranged as a trimer of dimers.|||Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. http://togogenome.org/gene/319706:G6N46_RS27100 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZZG8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.|||Homotetramer.|||Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP. http://togogenome.org/gene/319706:G6N46_RS11380 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZLZ7 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/319706:G6N46_RS05260 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZJV9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/319706:G6N46_RS15900 ^@ http://purl.uniprot.org/uniprot/A7BJ27 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/319706:G6N46_RS11455 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZNJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. http://togogenome.org/gene/319706:G6N46_RS02645 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZH26 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/319706:G6N46_RS18050 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZS86 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/319706:G6N46_RS01285 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZHF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/319706:G6N46_RS28010 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZWP0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 23 kDa subunit family.|||Binds 2 [4Fe-4S] clusters per subunit.|||Cell membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/319706:G6N46_RS18315 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZR15 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6. http://togogenome.org/gene/319706:G6N46_RS00735 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZK25 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/319706:G6N46_RS18020 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZQV7 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/319706:G6N46_RS16510 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZSU7 ^@ Similarity ^@ Belongs to the F420H(2)-dependent quinone reductase family. http://togogenome.org/gene/319706:G6N46_RS24140 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZUH0 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/319706:G6N46_RS24255 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZVW8 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/319706:G6N46_RS02915 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZIL1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterioferritin family.|||Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.|||Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex. http://togogenome.org/gene/319706:G6N46_RS27210 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZW55 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type-II 3-dehydroquinase family.|||Catalyzes a trans-dehydration via an enolate intermediate.|||Homododecamer. http://togogenome.org/gene/319706:G6N46_RS08685 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZNM9 ^@ Caution|||PTM|||Subcellular Location Annotation|||Subunit ^@ Binds 2 heme c groups covalently per subunit.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit. http://togogenome.org/gene/319706:G6N46_RS04740 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZL89 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/319706:G6N46_RS10140 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZLH9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/319706:G6N46_RS13095 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZQX1 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/319706:G6N46_RS28150 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZWQ0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF2.|||Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. http://togogenome.org/gene/319706:G6N46_RS27995 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZZ80 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/319706:G6N46_RS18015 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZQW1 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/319706:G6N46_RS20665 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZSD1 ^@ Function|||Similarity ^@ Belongs to the EgtB family.|||Catalyzes the oxidative sulfurization of hercynine (N-alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. http://togogenome.org/gene/319706:G6N46_RS12385 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZN58 ^@ Cofactor|||Function ^@ Binds 1 [3Fe-4S] cluster.|||Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/319706:G6N46_RS24160 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZVU6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/319706:G6N46_RS04915 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZJP9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit.|||Binds 2 divalent ions per subunit.|||Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.|||Cytoplasm|||Homotetramer; dimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/319706:G6N46_RS24130 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZUD1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/319706:G6N46_RS14135 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZNI4 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/319706:G6N46_RS10490 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZM25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Cell membrane|||Membrane http://togogenome.org/gene/319706:G6N46_RS07480 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZP40 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 1 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/319706:G6N46_RS01655 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZHY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MgtC/SapB family.|||Membrane http://togogenome.org/gene/319706:G6N46_RS06825 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZK12 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspG family.|||Binds 1 [4Fe-4S] cluster.|||Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. http://togogenome.org/gene/319706:G6N46_RS23355 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZXA3 ^@ Caution|||Function|||Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.|||Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/319706:G6N46_RS01685 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZIV7 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/319706:G6N46_RS08165 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZKT3 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATP phosphoribosyltransferase family. Long subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Equilibrium between an active dimeric form, an inactive hexameric form and higher aggregates. Interconversion between the various forms is largely reversible and is influenced by the natural substrates and inhibitors of the enzyme.|||Feedback inhibited by histidine. http://togogenome.org/gene/319706:G6N46_RS24475 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZUJ6 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/319706:G6N46_RS24815 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZUQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TsaE family.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD. http://togogenome.org/gene/319706:G6N46_RS21420 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZUG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/319706:G6N46_RS13615 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZNC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.|||Cytoplasm|||In the C-terminal section; belongs to the helicase family. RecG subfamily.|||In the N-terminal section; belongs to the UvrB family. http://togogenome.org/gene/319706:G6N46_RS03830 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZKT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Cytoplasm|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. http://togogenome.org/gene/319706:G6N46_RS17715 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZSB0 ^@ Similarity ^@ Belongs to the WXG100 family. http://togogenome.org/gene/319706:G6N46_RS04460 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZKJ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/319706:G6N46_RS17620 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZQL8 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/319706:G6N46_RS27465 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZYP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cutinase family.|||Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.|||Secreted http://togogenome.org/gene/319706:G6N46_RS22825 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZTS4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cell surface|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.|||capsule|||cell wall http://togogenome.org/gene/319706:G6N46_RS10665 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZMY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Cytoplasm|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. http://togogenome.org/gene/319706:G6N46_RS07250 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZJW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ A probable RNA-binding protein.|||Belongs to the KhpA RNA-binding protein family.|||Cytoplasm http://togogenome.org/gene/319706:G6N46_RS19570 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZRQ9 ^@ Similarity ^@ Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family. http://togogenome.org/gene/319706:G6N46_RS26800 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZZ97 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/319706:G6N46_RS24480 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZX01 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/319706:G6N46_RS22320 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZTD0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Cytoplasm|||Homodimer.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/319706:G6N46_RS08605 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZMY7 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 Mg(2+) ion per subunit.|||Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA.|||Homodimer. http://togogenome.org/gene/319706:G6N46_RS04500 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZI90 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/319706:G6N46_RS07240 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZMM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/319706:G6N46_RS17615 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZT73 ^@ Function|||Similarity ^@ Belongs to the carbohydrate kinase PfkB family.|||Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate. http://togogenome.org/gene/319706:G6N46_RS22740 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZU23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/319706:G6N46_RS19280 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZU25 ^@ Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. http://togogenome.org/gene/319706:G6N46_RS01260 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZJA7 ^@ Function|||Similarity ^@ Belongs to the NadC/ModD family.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/319706:G6N46_RS05840 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZLY0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ChdC family. Type 2 subfamily.|||Fe-coproporphyrin III acts as both substrate and redox cofactor.|||Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway. The reaction occurs in a stepwise manner with a three-propionate intermediate. http://togogenome.org/gene/319706:G6N46_RS18030 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZQV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecF family.|||Cytoplasm|||The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. http://togogenome.org/gene/319706:G6N46_RS06295 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZM67 ^@ Similarity ^@ Belongs to the PspA/IM30 family. http://togogenome.org/gene/319706:G6N46_RS13190 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZPD4 ^@ Function|||Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||Could possibly oxidize fatty acids using specific components. http://togogenome.org/gene/319706:G6N46_RS12455 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZMS4 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/319706:G6N46_RS28020 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZWN6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the complex I 75 kDa subunit family.|||Binds 1 [2Fe-2S] cluster per subunit.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/319706:G6N46_RS21575 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZX15 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/319706:G6N46_RS13665 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZNE7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/319706:G6N46_RS23080 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZVH1 ^@ Function|||Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/319706:G6N46_RS08880 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZNL8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/319706:G6N46_RS27690 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZXZ4 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/319706:G6N46_RS24230 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZWU7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/319706:G6N46_RS07210 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZM55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0126 family.|||Membrane http://togogenome.org/gene/319706:G6N46_RS23710 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZWT4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/319706:G6N46_RS26925 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZXK1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/319706:G6N46_RS16315 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZQD5 ^@ Function|||Similarity ^@ Belongs to the Stf0 sulfotransferase family.|||Catalyzes the sulfuryl group transfer from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to trehalose, leading to trehalose-2-sulfate (T2S). http://togogenome.org/gene/319706:G6N46_RS17745 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZQQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EccB family.|||Membrane http://togogenome.org/gene/319706:G6N46_RS16305 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZPV4 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/319706:G6N46_RS24470 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZUL4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/319706:G6N46_RS27650 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZZU7 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Probable amino-acid or metabolite transport protein. http://togogenome.org/gene/319706:G6N46_RS24125 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZUD7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/319706:G6N46_RS00300 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZGB1 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/319706:G6N46_RS26835 ^@ http://purl.uniprot.org/uniprot/A0A7I8A015 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GtrA family.|||Membrane http://togogenome.org/gene/319706:G6N46_RS06635 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZKQ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/319706:G6N46_RS20105 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZS13 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).|||Homodimer. http://togogenome.org/gene/319706:G6N46_RS05100 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZIM7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shikimate kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.|||Cytoplasm|||Monomer. http://togogenome.org/gene/319706:G6N46_RS18135 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZSI9 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/319706:G6N46_RS05850 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZJ09 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/319706:G6N46_RS23965 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZXM3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/319706:G6N46_RS27990 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZY59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4 family.|||Membrane http://togogenome.org/gene/319706:G6N46_RS07360 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZM88 ^@ Subunit ^@ F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains. http://togogenome.org/gene/319706:G6N46_RS15600 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZTL2 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/319706:G6N46_RS09805 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZL66 ^@ Similarity ^@ Belongs to the thioesterase family. http://togogenome.org/gene/319706:G6N46_RS05535 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZIV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/319706:G6N46_RS26295 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZY76 ^@ Similarity ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. http://togogenome.org/gene/319706:G6N46_RS12740 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZPD2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/319706:G6N46_RS10255 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZNT8 ^@ Similarity ^@ Belongs to the AfsR/DnrI/RedD regulatory family. http://togogenome.org/gene/319706:G6N46_RS12665 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZQL9 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ 2 residues (Tyr-53 and Arg-56) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.|||Belongs to the sirtuin family. Class III subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. http://togogenome.org/gene/319706:G6N46_RS07910 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZKA6 ^@ Similarity ^@ Belongs to the CsoR family. http://togogenome.org/gene/319706:G6N46_RS07365 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZJW8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/319706:G6N46_RS14680 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZT55 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/319706:G6N46_RS26715 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZYA2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Maf family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. http://togogenome.org/gene/319706:G6N46_RS21330 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZT69 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DisA family.|||Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.|||Homooctamer.|||Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions. http://togogenome.org/gene/319706:G6N46_RS00030 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZIJ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.|||Forms a membrane-associated complex with FtsE.|||Membrane|||Part of the ABC transporter FtsEX involved in cellular division. http://togogenome.org/gene/319706:G6N46_RS17585 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZUT2 ^@ Function|||Similarity ^@ Belongs to the UPF0677 family.|||Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity. http://togogenome.org/gene/319706:G6N46_RS10590 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZLJ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/319706:G6N46_RS20740 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZWJ0 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/319706:G6N46_RS13000 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZP90 ^@ Cofactor|||Similarity ^@ Belongs to the fatty acid desaturase type 2 family.|||Binds 2 iron ions per subunit. http://togogenome.org/gene/319706:G6N46_RS10530 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZLK2 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/319706:G6N46_RS14465 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZWP8 ^@ Function|||Similarity ^@ Belongs to the transposase mutator family.|||Required for the transposition of the insertion element. http://togogenome.org/gene/319706:G6N46_RS24115 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZX03 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/319706:G6N46_RS28015 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZZ12 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 1 family.|||Cell membrane|||Membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. http://togogenome.org/gene/319706:G6N46_RS23160 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZX60 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Monomer.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethane group. http://togogenome.org/gene/319706:G6N46_RS07465 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZJZ1 ^@ Function|||PTM|||Similarity ^@ An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.|||Belongs to the polyphosphate kinase 1 (PPK1) family.|||Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). http://togogenome.org/gene/319706:G6N46_RS13710 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZRH8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.|||Cytoplasm|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/319706:G6N46_RS16855 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZRE5 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.|||Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/319706:G6N46_RS01870 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZGT6 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/319706:G6N46_RS16540 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZRK3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/319706:G6N46_RS20600 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZTM5 ^@ Function|||Similarity ^@ Belongs to the aspartokinase family.|||Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine. http://togogenome.org/gene/319706:G6N46_RS23970 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZUA6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/319706:G6N46_RS00025 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZID9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Homodimer. Forms a membrane-associated complex with FtsX.|||Part of the ABC transporter FtsEX involved in cellular division. http://togogenome.org/gene/319706:G6N46_RS11550 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZM28 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/319706:G6N46_RS26855 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZVX6 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/319706:G6N46_RS13640 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZNX7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/319706:G6N46_RS05640 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZL85 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/319706:G6N46_RS24165 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZX13 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/319706:G6N46_RS08435 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZND1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SepF family.|||Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.|||Cytoplasm|||Homodimer. Interacts with FtsZ. http://togogenome.org/gene/319706:G6N46_RS17890 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZU08 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/319706:G6N46_RS08720 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZPU4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with subunits I, II and III to form cytochrome c oxidase.|||Belongs to the cytochrome c oxidase bacterial subunit CtaF family.|||Cell membrane|||Membrane|||Part of cytochrome c oxidase, its function is unknown. http://togogenome.org/gene/319706:G6N46_RS12280 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZMI2 ^@ Similarity ^@ Belongs to the HSP15 family. http://togogenome.org/gene/319706:G6N46_RS01215 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZGF8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. Biotin synthase family.|||Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/319706:G6N46_RS17580 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZR27 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/319706:G6N46_RS03100 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZHX3 ^@ Cofactor|||Similarity ^@ Belongs to the Fur family.|||Binds 1 Mn(2+) or Fe(2+) ion per subunit.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/319706:G6N46_RS11465 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZRB6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/319706:G6N46_RS17635 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZUU3 ^@ Similarity ^@ Belongs to the EccE family. http://togogenome.org/gene/319706:G6N46_RS13035 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZNJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic pantothenate kinase family.|||Cytoplasm http://togogenome.org/gene/319706:G6N46_RS23980 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZWP9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/319706:G6N46_RS16320 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZU05 ^@ Similarity ^@ Belongs to the PAPS reductase family. CysD subfamily. http://togogenome.org/gene/319706:G6N46_RS26725 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZXF6 ^@ Similarity ^@ Belongs to the AccD/PCCB family. http://togogenome.org/gene/319706:G6N46_RS11450 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZM06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/319706:G6N46_RS24215 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZXS0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/319706:G6N46_RS26815 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZYC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial sugar transferase family.|||Membrane http://togogenome.org/gene/319706:G6N46_RS08430 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZLS1 ^@ Similarity ^@ Belongs to the YggT family. http://togogenome.org/gene/319706:G6N46_RS00475 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZG03 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/319706:G6N46_RS14470 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZRE8 ^@ Function|||Similarity ^@ Belongs to the transposase mutator family.|||Required for the transposition of the insertion element. http://togogenome.org/gene/319706:G6N46_RS13060 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZN16 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/319706:G6N46_RS03810 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZIA6 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/319706:G6N46_RS25625 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZWP8 ^@ Function|||Similarity ^@ Belongs to the transposase mutator family.|||Required for the transposition of the insertion element. http://togogenome.org/gene/319706:G6N46_RS28005 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZWM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 6 family.|||Cell membrane|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/319706:G6N46_RS24155 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZYG7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/319706:G6N46_RS28170 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZIJ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.|||Forms a membrane-associated complex with FtsE.|||Membrane|||Part of the ABC transporter FtsEX involved in cellular division. http://togogenome.org/gene/319706:G6N46_RS16310 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZRE4 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/319706:G6N46_RS07725 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZK36 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/319706:G6N46_RS24225 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZUE7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/319706:G6N46_RS24285 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZUJ9 ^@ Function|||Similarity ^@ Belongs to the UPF0677 family.|||Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity. http://togogenome.org/gene/319706:G6N46_RS01875 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZGV4 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/319706:G6N46_RS09975 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZML6 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/319706:G6N46_RS07475 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZKD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial histone-like protein family. Long actinobacterial subfamily.|||nucleoid http://togogenome.org/gene/319706:G6N46_RS28000 ^@ http://purl.uniprot.org/uniprot/A0A7I8A036 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4L family.|||Cell membrane|||Membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/319706:G6N46_RS03775 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZJ11 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer.|||Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0). http://togogenome.org/gene/319706:G6N46_RS08875 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZM14 ^@ Similarity ^@ Belongs to the darcynin family. http://togogenome.org/gene/319706:G6N46_RS22745 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZXR2 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).|||Cell membrane|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. http://togogenome.org/gene/319706:G6N46_RS08775 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZLZ3 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/319706:G6N46_RS07485 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZL60 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/319706:G6N46_RS08850 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZN31 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LipB family.|||Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.|||Cytoplasm|||In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes. http://togogenome.org/gene/319706:G6N46_RS03060 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZIN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TerC family.|||Membrane http://togogenome.org/gene/319706:G6N46_RS28050 ^@ http://purl.uniprot.org/uniprot/A0A7I8A046 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 3 family.|||Cell membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/319706:G6N46_RS23750 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZUU1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/319706:G6N46_RS28030 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZXG8 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/319706:G6N46_RS06950 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZJQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/319706:G6N46_RS03935 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZKV2 ^@ Similarity ^@ Belongs to the asp23 family. http://togogenome.org/gene/319706:G6N46_RS19450 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZUE4 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems.|||Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/319706:G6N46_RS08215 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZKU4 ^@ Function|||Similarity ^@ Belongs to the transposase mutator family.|||Required for the transposition of the insertion element. http://togogenome.org/gene/319706:G6N46_RS11540 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZM58 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the Rho family.|||Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.|||Homohexamer. The homohexamer assembles into an open ring structure.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/319706:G6N46_RS24460 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZX67 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/319706:G6N46_RS24250 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZYI3 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/319706:G6N46_RS00140 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZFK5 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.|||Cell membrane|||Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Membrane|||Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function. http://togogenome.org/gene/319706:G6N46_RS11475 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZPZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase B chain family.|||Cell membrane|||Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Membrane http://togogenome.org/gene/319706:G6N46_RS01440 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZGZ6 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/319706:G6N46_RS13915 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZRD1 ^@ Similarity ^@ Belongs to the AccD/PCCB family. http://togogenome.org/gene/319706:G6N46_RS11515 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZRC6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.|||Binds 1 zinc ion per subunit.|||Binds the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/319706:G6N46_RS05575 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZLS2 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvB family.|||Cytoplasm|||Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.|||Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA. http://togogenome.org/gene/319706:G6N46_RS04925 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZMM8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase subunit omega family.|||Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/319706:G6N46_RS13700 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZPL6 ^@ Similarity ^@ Belongs to the transglycosylase family. Rpf subfamily. http://togogenome.org/gene/319706:G6N46_RS13775 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZR16 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL31 family. http://togogenome.org/gene/319706:G6N46_RS22670 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZTL0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/319706:G6N46_RS08550 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZKK5 ^@ Cofactor|||Similarity ^@ Belongs to the class-II DAHP synthase family.|||Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions. http://togogenome.org/gene/319706:G6N46_RS21085 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZWP5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/319706:G6N46_RS18730 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZU22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/319706:G6N46_RS19470 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZRP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferritin family. Prokaryotic subfamily.|||Cytoplasm|||Iron-storage protein. http://togogenome.org/gene/319706:G6N46_RS09720 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZMI5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endoribonuclease YbeY family.|||Binds 1 zinc ion.|||Cytoplasm|||Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. http://togogenome.org/gene/319706:G6N46_RS04005 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZJ67 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/319706:G6N46_RS01535 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZGF3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/319706:G6N46_RS11495 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZPH5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/319706:G6N46_RS13930 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZNH6 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/319706:G6N46_RS26930 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZWS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. AlkB subfamily.|||Cell inner membrane|||Membrane http://togogenome.org/gene/319706:G6N46_RS04775 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZMK1 ^@ Function|||Similarity ^@ Belongs to the WhiA family.|||Involved in cell division and chromosome segregation. http://togogenome.org/gene/319706:G6N46_RS06955 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZJP2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/319706:G6N46_RS08900 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZN39 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/319706:G6N46_RS06515 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZJE4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/319706:G6N46_RS26660 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZVU7 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/319706:G6N46_RS24135 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZWS6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/319706:G6N46_RS17630 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZR36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/319706:G6N46_RS20015 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZUF5 ^@ Similarity ^@ Belongs to the MmpS family. http://togogenome.org/gene/319706:G6N46_RS15450 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZTI4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PurS family.|||Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/319706:G6N46_RS17085 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZRX0 ^@ Similarity ^@ Belongs to the long-chain O-acyltransferase family. http://togogenome.org/gene/319706:G6N46_RS21215 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZV24 ^@ Similarity ^@ Belongs to the UPF0145 family. http://togogenome.org/gene/319706:G6N46_RS27085 ^@ http://purl.uniprot.org/uniprot/A0A7I8A066 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell membrane|||Cytoplasm|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/319706:G6N46_RS05095 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZIK7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.|||Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).|||Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/319706:G6N46_RS22625 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZVY0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in favoring mycobacterial survival in phagocytes. http://togogenome.org/gene/319706:G6N46_RS06875 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZK23 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RlmN family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm|||Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.|||Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. http://togogenome.org/gene/319706:G6N46_RS16935 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZQ81 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/319706:G6N46_RS05555 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZJ79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YajC family.|||Membrane http://togogenome.org/gene/319706:G6N46_RS15290 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZQS0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/319706:G6N46_RS10080 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZMN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyl phosphate reductase family.|||Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.|||Cytoplasm http://togogenome.org/gene/319706:G6N46_RS08510 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZKJ5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MraZ family.|||Forms oligomers.|||nucleoid http://togogenome.org/gene/319706:G6N46_RS05635 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZIW6 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/319706:G6N46_RS12710 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZQN0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/319706:G6N46_RS08145 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZKD1 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/319706:G6N46_RS12745 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZNC8 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/319706:G6N46_RS08425 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZPP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DivIVA family.|||Cytoplasm http://togogenome.org/gene/319706:G6N46_RS06165 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZJ75 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase S24 family.|||Homodimer.|||Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. http://togogenome.org/gene/319706:G6N46_RS17975 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZSF3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CrgA family.|||Cell membrane|||Involved in cell division. http://togogenome.org/gene/319706:G6N46_RS24955 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZUW2 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.|||Belongs to the WhiB family.|||Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.|||Cytoplasm|||The Fe-S cluster can be nitrosylated by nitric oxide (NO).|||Upon Fe-S cluster removal intramolecular disulfide bonds are formed. http://togogenome.org/gene/319706:G6N46_RS08855 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZKQ5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Cytoplasm http://togogenome.org/gene/319706:G6N46_RS21475 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZT98 ^@ Function|||Similarity ^@ Belongs to the transposase mutator family.|||Required for the transposition of the insertion element. http://togogenome.org/gene/319706:G6N46_RS06000 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZJ37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.|||Cell inner membrane|||Cell membrane|||Membrane|||Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. http://togogenome.org/gene/319706:G6N46_RS21765 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZT19 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/319706:G6N46_RS17575 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZS79 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/319706:G6N46_RS18250 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZSB8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.|||Cytoplasm|||Homodimer.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/319706:G6N46_RS10245 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZLJ6 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/319706:G6N46_RS03290 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZIU7 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Probable amino-acid or metabolite transport protein. http://togogenome.org/gene/319706:G6N46_RS16370 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZU17 ^@ Similarity ^@ Belongs to the WXG100 family. http://togogenome.org/gene/319706:G6N46_RS00505 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZIM8 ^@ Function|||Similarity ^@ Belongs to the glutaredoxin family.|||Electron transport system for the ribonucleotide reductase system NrdEF. http://togogenome.org/gene/319706:G6N46_RS10480 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZLH7 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.|||Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).|||The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.|||The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1. http://togogenome.org/gene/319706:G6N46_RS21175 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZUA4 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanD family.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.|||Cytoplasm|||Heterooctamer of four alpha and four beta subunits.|||Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus. http://togogenome.org/gene/319706:G6N46_RS00810 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZG74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Cell membrane|||Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.|||Membrane http://togogenome.org/gene/319706:G6N46_RS07230 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZNZ0 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/319706:G6N46_RS08480 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZLT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. MraY subfamily.|||Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.|||Cell membrane|||Membrane http://togogenome.org/gene/319706:G6N46_RS08760 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZM12 ^@ Function|||Similarity ^@ Belongs to the CobU/CobP family.|||Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. http://togogenome.org/gene/319706:G6N46_RS26065 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZVG7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/319706:G6N46_RS22005 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZVT9 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/319706:G6N46_RS24450 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZW09 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/319706:G6N46_RS28080 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZXH7 ^@ Similarity ^@ Belongs to the HMG-CoA lyase family. http://togogenome.org/gene/319706:G6N46_RS28580 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZIG5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/319706:G6N46_RS12210 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZQE8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.|||Homotetramer.|||Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. http://togogenome.org/gene/319706:G6N46_RS09715 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZL39 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/319706:G6N46_RS23235 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZVJ7 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/319706:G6N46_RS21775 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZVE2 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/319706:G6N46_RS09245 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZKX8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||Acyl carrier protein involved in meromycolate extension.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/319706:G6N46_RS25580 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZWP8 ^@ Function|||Similarity ^@ Belongs to the transposase mutator family.|||Required for the transposition of the insertion element. http://togogenome.org/gene/319706:G6N46_RS24260 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZX31 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/319706:G6N46_RS10605 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZQV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-to-5' exoribonuclease specific for small oligoribonucleotides.|||Belongs to the oligoribonuclease family.|||Cytoplasm http://togogenome.org/gene/319706:G6N46_RS17750 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZQQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CbxX/CfxQ family.|||Cytoplasm http://togogenome.org/gene/319706:G6N46_RS03770 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZM11 ^@ Function|||Similarity ^@ Belongs to the MerB family.|||Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. One product is Hg(2+), which is subsequently detoxified by the mercuric reductase. http://togogenome.org/gene/319706:G6N46_RS28045 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZZ90 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 20 kDa subunit family.|||Binds 1 [4Fe-4S] cluster.|||Cell membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/319706:G6N46_RS12020 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZQA6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/319706:G6N46_RS15390 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZQU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/319706:G6N46_RS01005 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZIY6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/319706:G6N46_RS06435 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZKJ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/319706:G6N46_RS15365 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZSF4 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity ^@ Belongs to the nitrobindin family.|||Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.|||Forms a 10-stranded antiparallel beta-barrel structure able to accommodate a hydrophobic ligand in its interior. In fact, this fold hosts the heme group, which is located in a wide surface cleft.|||Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/319706:G6N46_RS21145 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZVA8 ^@ Function|||Similarity ^@ Belongs to the DHNA family.|||Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. http://togogenome.org/gene/319706:G6N46_RS11555 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZNM3 ^@ Similarity ^@ Belongs to the homoserine dehydrogenase family. http://togogenome.org/gene/319706:G6N46_RS11525 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZQ08 ^@ Similarity ^@ Belongs to the YciI family. http://togogenome.org/gene/319706:G6N46_RS26555 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZVR8 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/319706:G6N46_RS10525 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZLN5 ^@ Function|||Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||Could possibly oxidize fatty acids using specific components. http://togogenome.org/gene/319706:G6N46_RS11480 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZQ77 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/319706:G6N46_RS13715 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZNF7 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/319706:G6N46_RS15610 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZS93 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/319706:G6N46_RS13290 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZPF0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/319706:G6N46_RS27660 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZWE2 ^@ Similarity ^@ Belongs to the F420H(2)-dependent quinone reductase family. http://togogenome.org/gene/319706:G6N46_RS20440 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZTS7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YbaB/EbfC family.|||Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.|||Homodimer.|||nucleoid http://togogenome.org/gene/319706:G6N46_RS04780 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZJL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gluconeogenesis factor family.|||Cytoplasm|||Required for morphogenesis under gluconeogenic growth conditions. http://togogenome.org/gene/319706:G6N46_RS19100 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZRZ2 ^@ Cofactor|||Domain|||Function|||Similarity ^@ Belongs to the nitrobindin family.|||Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.|||Forms a 10-stranded antiparallel beta-barrel structure able to accommodate a hydrophobic ligand in its interior. In fact, this fold hosts the heme group, which is located in a wide surface cleft.|||Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo. http://togogenome.org/gene/319706:G6N46_RS20890 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZTT4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/319706:G6N46_RS28025 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZYA1 ^@ Function|||Similarity ^@ Belongs to the complex I 51 kDa subunit family.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. http://togogenome.org/gene/319706:G6N46_RS20805 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZVM5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/319706:G6N46_RS24625 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZX28 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/319706:G6N46_RS15530 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZS07 ^@ Similarity ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. http://togogenome.org/gene/319706:G6N46_RS05605 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZJ88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/319706:G6N46_RS27095 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZYN2 ^@ Similarity ^@ Belongs to the long-chain O-acyltransferase family. http://togogenome.org/gene/319706:G6N46_RS07245 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZMS3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.|||Belongs to the RimM family.|||Binds ribosomal protein uS19.|||Cytoplasm|||The PRC barrel domain binds ribosomal protein uS19. http://togogenome.org/gene/319706:G6N46_RS10585 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZNZ8 ^@ Similarity ^@ Belongs to the MmpS family. http://togogenome.org/gene/319706:G6N46_RS10135 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZPG4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/319706:G6N46_RS14045 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZP55 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/319706:G6N46_RS08920 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZPX6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/319706:G6N46_RS09680 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZQC0 ^@ Cofactor|||Similarity ^@ Belongs to the Fur family.|||Binds 1 Mn(2+) or Fe(2+) ion per subunit.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/319706:G6N46_RS24980 ^@ http://purl.uniprot.org/uniprot/A0A7I7ZVN8 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.