http://togogenome.org/gene/335541:SWOL_RS07665 ^@ http://purl.uniprot.org/uniprot/Q0AWX0 ^@ Similarity ^@ In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family. http://togogenome.org/gene/335541:SWOL_RS09440 ^@ http://purl.uniprot.org/uniprot/Q0AVX9 ^@ Function|||Similarity ^@ Belongs to the MoeA family.|||Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. http://togogenome.org/gene/335541:SWOL_RS10695 ^@ http://purl.uniprot.org/uniprot/Q0AV93 ^@ Similarity ^@ Belongs to the CbxX/CfxQ family. http://togogenome.org/gene/335541:SWOL_RS10070 ^@ http://purl.uniprot.org/uniprot/Q0AVK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS11990 ^@ http://purl.uniprot.org/uniprot/Q0AUJ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/335541:SWOL_RS11975 ^@ http://purl.uniprot.org/uniprot/Q0AUK2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/335541:SWOL_RS02515 ^@ http://purl.uniprot.org/uniprot/Q0AZM3 ^@ Similarity ^@ Belongs to the type IA topoisomerase family. http://togogenome.org/gene/335541:SWOL_RS09450 ^@ http://purl.uniprot.org/uniprot/Q0AVX7 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/335541:SWOL_RS03990 ^@ http://purl.uniprot.org/uniprot/Q0AYU3 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/335541:SWOL_RS12270 ^@ http://purl.uniprot.org/uniprot/Q0AUE9 ^@ Domain|||Function|||Similarity ^@ Belongs to the RecA family. RadA subfamily.|||DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.|||Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.|||The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. http://togogenome.org/gene/335541:SWOL_RS08840 ^@ http://purl.uniprot.org/uniprot/Q0AW95 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/335541:SWOL_RS06350 ^@ http://purl.uniprot.org/uniprot/Q0AXK9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase subunit omega family.|||Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/335541:SWOL_RS01610 ^@ http://purl.uniprot.org/uniprot/Q0B046 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS01580 ^@ http://purl.uniprot.org/uniprot/Q0B052 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyl-CoA hydrolase/transferase family.|||Coenzyme A-transferase that converts butyrate to butyryl-CoA.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS02840 ^@ http://purl.uniprot.org/uniprot/Q0AZG1 ^@ Function|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.|||This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/335541:SWOL_RS11955 ^@ http://purl.uniprot.org/uniprot/Q0AUK6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/335541:SWOL_RS13240 ^@ http://purl.uniprot.org/uniprot/Q0ATV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SelA family.|||Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS04475 ^@ http://purl.uniprot.org/uniprot/Q0AYJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS05910 ^@ http://purl.uniprot.org/uniprot/Q0AXU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS01360 ^@ http://purl.uniprot.org/uniprot/Q0B094 ^@ Function|||Similarity ^@ Belongs to the RapZ-like family.|||Displays ATPase and GTPase activities. http://togogenome.org/gene/335541:SWOL_RS04330 ^@ http://purl.uniprot.org/uniprot/Q0AYM8 ^@ Similarity ^@ Belongs to the flagella basal body rod proteins family. http://togogenome.org/gene/335541:SWOL_RS09615 ^@ http://purl.uniprot.org/uniprot/Q0AVU6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.|||Monomer and homodimer. http://togogenome.org/gene/335541:SWOL_RS01255 ^@ http://purl.uniprot.org/uniprot/Q0B0B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS01310 ^@ http://purl.uniprot.org/uniprot/Q0B0A2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/335541:SWOL_RS09200 ^@ http://purl.uniprot.org/uniprot/Q0AW29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS12095 ^@ http://purl.uniprot.org/uniprot/Q0AUH8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/335541:SWOL_RS09545 ^@ http://purl.uniprot.org/uniprot/Q0AVW0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccD/PCCB family.|||Binds 1 zinc ion per subunit.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS03945 ^@ http://purl.uniprot.org/uniprot/Q0AYV2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine. http://togogenome.org/gene/335541:SWOL_RS10815 ^@ http://purl.uniprot.org/uniprot/Q0AV72 ^@ Similarity ^@ Belongs to the UPF0251 family. http://togogenome.org/gene/335541:SWOL_RS10225 ^@ http://purl.uniprot.org/uniprot/Q0AVI0 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/335541:SWOL_RS07485 ^@ http://purl.uniprot.org/uniprot/Q0AWZ9 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/335541:SWOL_RS08215 ^@ http://purl.uniprot.org/uniprot/Q0AWL5 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/335541:SWOL_RS08580 ^@ http://purl.uniprot.org/uniprot/Q0AWE5 ^@ Similarity ^@ Belongs to the HicA mRNA interferase family. http://togogenome.org/gene/335541:SWOL_RS04620 ^@ http://purl.uniprot.org/uniprot/Q0AYH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MgtC/SapB family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS10185 ^@ http://purl.uniprot.org/uniprot/Q0AVI6 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/335541:SWOL_RS03135 ^@ http://purl.uniprot.org/uniprot/Q0AZA6 ^@ Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.|||Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. http://togogenome.org/gene/335541:SWOL_RS12040 ^@ http://purl.uniprot.org/uniprot/Q0AUI9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/335541:SWOL_RS12215 ^@ http://purl.uniprot.org/uniprot/Q0AUF9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MrnC RNase family.|||Cytoplasm|||Homodimer.|||Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors. http://togogenome.org/gene/335541:SWOL_RS00055 ^@ http://purl.uniprot.org/uniprot/Q0B0Y6 ^@ Function|||Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate. http://togogenome.org/gene/335541:SWOL_RS12035 ^@ http://purl.uniprot.org/uniprot/Q0AUJ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/335541:SWOL_RS01835 ^@ http://purl.uniprot.org/uniprot/Q0B006 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS06880 ^@ http://purl.uniprot.org/uniprot/Q0AXB7 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CheB family.|||Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.|||Cytoplasm|||Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.|||Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity. http://togogenome.org/gene/335541:SWOL_RS08980 ^@ http://purl.uniprot.org/uniprot/Q0AW67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS04355 ^@ http://purl.uniprot.org/uniprot/Q0AYM3 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/335541:SWOL_RS06590 ^@ http://purl.uniprot.org/uniprot/Q0AXG3 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/335541:SWOL_RS09030 ^@ http://purl.uniprot.org/uniprot/Q0AW62 ^@ Similarity ^@ Belongs to the acetyl-CoA hydrolase/transferase family. http://togogenome.org/gene/335541:SWOL_RS00555 ^@ http://purl.uniprot.org/uniprot/Q0B0P9 ^@ Function|||Similarity ^@ Belongs to the DHNA family.|||Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. http://togogenome.org/gene/335541:SWOL_RS00965 ^@ http://purl.uniprot.org/uniprot/Q0B0H0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS05120 ^@ http://purl.uniprot.org/uniprot/Q0AY82 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase S24 family.|||Homodimer.|||Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. http://togogenome.org/gene/335541:SWOL_RS06625 ^@ http://purl.uniprot.org/uniprot/Q0AUU4 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/335541:SWOL_RS12225 ^@ http://purl.uniprot.org/uniprot/Q0AUF8 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/335541:SWOL_RS09990 ^@ http://purl.uniprot.org/uniprot/Q0AVM4 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA dehydrogenase family.|||Cytoplasm|||Highly expressed during syntrophic growth with butyrate (at protein level) (PubMed:19648244, PubMed:23468890). Seems to be constitutively expressed (PubMed:23468890).|||Involved in syntrophic growth of S.wolfei with butyrate, as part of the butyrate oxidation pathway. Catalyzes the oxidation of butanoyl-CoA to crotonyl-CoA. Probably passes the electrons released by this reaction on to electron-transfer flavoproteins (EtfAB) to finally generate hydrogen and/or formate. http://togogenome.org/gene/335541:SWOL_RS05925 ^@ http://purl.uniprot.org/uniprot/Q0AXT8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MqnE family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. http://togogenome.org/gene/335541:SWOL_RS09375 ^@ http://purl.uniprot.org/uniprot/Q0AVZ3 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/335541:SWOL_RS05645 ^@ http://purl.uniprot.org/uniprot/Q0AXY6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.|||Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS13380 ^@ http://purl.uniprot.org/uniprot/Q0B0J0 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/335541:SWOL_RS08535 ^@ http://purl.uniprot.org/uniprot/Q0AWF4 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/335541:SWOL_RS03355 ^@ http://purl.uniprot.org/uniprot/Q0AZ64 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS05760 ^@ http://purl.uniprot.org/uniprot/Q0AXW9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS04460 ^@ http://purl.uniprot.org/uniprot/Q0AYK2 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP. http://togogenome.org/gene/335541:SWOL_RS04205 ^@ http://purl.uniprot.org/uniprot/Q0AYQ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/335541:SWOL_RS03690 ^@ http://purl.uniprot.org/uniprot/Q0AZ00 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS12395 ^@ http://purl.uniprot.org/uniprot/Q0AUC4 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/335541:SWOL_RS12160 ^@ http://purl.uniprot.org/uniprot/Q0AUG5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. http://togogenome.org/gene/335541:SWOL_RS09335 ^@ http://purl.uniprot.org/uniprot/Q0AW01 ^@ Similarity ^@ In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.|||In the central section; belongs to the CRISPR-associated helicase Cas3 family. http://togogenome.org/gene/335541:SWOL_RS01285 ^@ http://purl.uniprot.org/uniprot/Q0B0A7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.|||Cell inner membrane|||Cell membrane|||Forms a membrane-associated complex with FtsE.|||Membrane|||Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation. http://togogenome.org/gene/335541:SWOL_RS04870 ^@ http://purl.uniprot.org/uniprot/Q0AYD0 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/335541:SWOL_RS01370 ^@ http://purl.uniprot.org/uniprot/Q0B092 ^@ Function|||Similarity ^@ Belongs to the WhiA family.|||Involved in cell division and chromosome segregation. http://togogenome.org/gene/335541:SWOL_RS01930 ^@ http://purl.uniprot.org/uniprot/Q0AZY7 ^@ Cofactor ^@ Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/335541:SWOL_RS08435 ^@ http://purl.uniprot.org/uniprot/Q0AWH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS12830 ^@ http://purl.uniprot.org/uniprot/Q0AU38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS11935 ^@ http://purl.uniprot.org/uniprot/Q0AUL0 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/335541:SWOL_RS10060 ^@ http://purl.uniprot.org/uniprot/Q0AVL0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS01365 ^@ http://purl.uniprot.org/uniprot/Q0B093 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gluconeogenesis factor family.|||Cytoplasm|||Required for morphogenesis under gluconeogenic growth conditions. http://togogenome.org/gene/335541:SWOL_RS10620 ^@ http://purl.uniprot.org/uniprot/Q0AVA8 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA dehydrogenase family.|||Cytoplasm|||Expressed during syntrophic growth with butyrate (at protein level) (PubMed:19648244, PubMed:23468890). Seems to be constitutively expressed (PubMed:23468890).|||Involved in syntrophic growth of S.wolfei with butyrate, as part of the butyrate oxidation pathway. Catalyzes the oxidation of butanoyl-CoA to crotonyl-CoA. Probably passes the electrons released by this reaction on to electron-transfer flavoproteins (EtfAB) to finally generate hydrogen and/or formate. http://togogenome.org/gene/335541:SWOL_RS03720 ^@ http://purl.uniprot.org/uniprot/Q0AYZ5 ^@ Similarity ^@ Belongs to the transposase IS21/IS408/IS1162 family. http://togogenome.org/gene/335541:SWOL_RS07685 ^@ http://purl.uniprot.org/uniprot/Q0AWW7 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/335541:SWOL_RS07365 ^@ http://purl.uniprot.org/uniprot/Q0AX23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecF subfamily.|||Cell membrane|||Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/335541:SWOL_RS05140 ^@ http://purl.uniprot.org/uniprot/Q0AY78 ^@ Cofactor|||Function ^@ Binds 2 [4Fe-4S] clusters.|||Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. http://togogenome.org/gene/335541:SWOL_RS10985 ^@ http://purl.uniprot.org/uniprot/Q0AV38 ^@ Similarity ^@ Belongs to the ETF-QO/FixC family. http://togogenome.org/gene/335541:SWOL_RS06215 ^@ http://purl.uniprot.org/uniprot/Q0AXN6 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/335541:SWOL_RS02100 ^@ http://purl.uniprot.org/uniprot/Q0AZV4 ^@ Similarity ^@ Belongs to the FldB/FldC dehydratase alpha/beta subunit family. http://togogenome.org/gene/335541:SWOL_RS04280 ^@ http://purl.uniprot.org/uniprot/Q0AYN7 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliE family. http://togogenome.org/gene/335541:SWOL_RS06055 ^@ http://purl.uniprot.org/uniprot/Q0AXR4 ^@ Function|||Similarity ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. http://togogenome.org/gene/335541:SWOL_RS09880 ^@ http://purl.uniprot.org/uniprot/Q0AVP4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS10000 ^@ http://purl.uniprot.org/uniprot/Q0AVM2 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.|||Cytoplasm|||Highly expressed during syntrophic growth with butyrate (at protein level). Seems to be constitutively expressed.|||Involved in syntrophic growth of S.wolfei with butyrate, as part of the butyrate oxidation pathway. Probably catalyzes the oxidation of 3-hydroxybutyryl-CoA to acetoacetyl-CoA. http://togogenome.org/gene/335541:SWOL_RS00460 ^@ http://purl.uniprot.org/uniprot/Q0B0R9 ^@ Similarity ^@ Belongs to the GerABKA family. http://togogenome.org/gene/335541:SWOL_RS06850 ^@ http://purl.uniprot.org/uniprot/Q0AXC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS06335 ^@ http://purl.uniprot.org/uniprot/Q0AXL2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. PriA subfamily.|||Component of the primosome.|||Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. http://togogenome.org/gene/335541:SWOL_RS04600 ^@ http://purl.uniprot.org/uniprot/Q0AYH5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS11855 ^@ http://purl.uniprot.org/uniprot/Q0AUM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS07690 ^@ http://purl.uniprot.org/uniprot/Q0AWW6 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/335541:SWOL_RS13290 ^@ http://purl.uniprot.org/uniprot/Q0ATU6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MnmG family.|||Cytoplasm|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. http://togogenome.org/gene/335541:SWOL_RS09235 ^@ http://purl.uniprot.org/uniprot/Q0AW21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS07420 ^@ http://purl.uniprot.org/uniprot/Q0AX12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS11945 ^@ http://purl.uniprot.org/uniprot/Q0AUK8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/335541:SWOL_RS04940 ^@ http://purl.uniprot.org/uniprot/Q0AYB7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methylthiotransferase family. MiaB subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.|||Cytoplasm|||Monomer. http://togogenome.org/gene/335541:SWOL_RS04350 ^@ http://purl.uniprot.org/uniprot/Q0AYM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FliN/MopA/SpaO family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS00580 ^@ http://purl.uniprot.org/uniprot/Q0B0P4 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanD family.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.|||Cytoplasm|||Heterooctamer of four alpha and four beta subunits.|||Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus. http://togogenome.org/gene/335541:SWOL_RS01885 ^@ http://purl.uniprot.org/uniprot/Q0AZZ6 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/335541:SWOL_RS01320 ^@ http://purl.uniprot.org/uniprot/Q0B0A0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrC family.|||Cytoplasm|||Interacts with UvrB in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. http://togogenome.org/gene/335541:SWOL_RS05580 ^@ http://purl.uniprot.org/uniprot/Q0AXZ9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/335541:SWOL_RS03920 ^@ http://purl.uniprot.org/uniprot/Q0AYV7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/335541:SWOL_RS08470 ^@ http://purl.uniprot.org/uniprot/Q0AWG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MreD family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS05115 ^@ http://purl.uniprot.org/uniprot/Q0AY83 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/335541:SWOL_RS01140 ^@ http://purl.uniprot.org/uniprot/Q0B0D6 ^@ Similarity ^@ Belongs to the HepT RNase toxin family. http://togogenome.org/gene/335541:SWOL_RS13585 ^@ http://purl.uniprot.org/uniprot/Q0AX11 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS08955 ^@ http://purl.uniprot.org/uniprot/Q0AW71 ^@ Similarity ^@ Belongs to the acetyl-CoA hydrolase/transferase family. http://togogenome.org/gene/335541:SWOL_RS13435 ^@ http://purl.uniprot.org/uniprot/Q0B010 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS02170 ^@ http://purl.uniprot.org/uniprot/Q0AZU1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS04640 ^@ http://purl.uniprot.org/uniprot/Q0AYG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Cell membrane|||Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).|||In the C-terminal section; belongs to the transpeptidase family.|||In the N-terminal section; belongs to the glycosyltransferase 51 family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS05210 ^@ http://purl.uniprot.org/uniprot/Q0AY64 ^@ Function|||Similarity ^@ Belongs to the MoeA family.|||Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. http://togogenome.org/gene/335541:SWOL_RS07855 ^@ http://purl.uniprot.org/uniprot/Q0AWT6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/335541:SWOL_RS05170 ^@ http://purl.uniprot.org/uniprot/Q0AY72 ^@ Similarity ^@ Belongs to the complex I 51 kDa subunit family. http://togogenome.org/gene/335541:SWOL_RS13170 ^@ http://purl.uniprot.org/uniprot/Q0ATW9 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/335541:SWOL_RS13320 ^@ http://purl.uniprot.org/uniprot/Q0ATU1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/335541:SWOL_RS13465 ^@ http://purl.uniprot.org/uniprot/Q0AZC4 ^@ Function|||Subcellular Location Annotation ^@ Cell inner membrane|||May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/335541:SWOL_RS12050 ^@ http://purl.uniprot.org/uniprot/Q0AUI7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/335541:SWOL_RS05985 ^@ http://purl.uniprot.org/uniprot/Q0AXS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1C family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS08325 ^@ http://purl.uniprot.org/uniprot/Q0AWJ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/335541:SWOL_RS09875 ^@ http://purl.uniprot.org/uniprot/Q0AVP5 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily. http://togogenome.org/gene/335541:SWOL_RS06855 ^@ http://purl.uniprot.org/uniprot/Q0AXC2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsY family.|||Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.|||Cell membrane|||Probably interacts with PlsX. http://togogenome.org/gene/335541:SWOL_RS08415 ^@ http://purl.uniprot.org/uniprot/Q0AWH7 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/335541:SWOL_RS10780 ^@ http://purl.uniprot.org/uniprot/Q0AV79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS04740 ^@ http://purl.uniprot.org/uniprot/Q0AYF6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the vitamin-B12 independent methionine synthase family.|||Binds 1 zinc ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation. http://togogenome.org/gene/335541:SWOL_RS10830 ^@ http://purl.uniprot.org/uniprot/Q0AV69 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/335541:SWOL_RS05875 ^@ http://purl.uniprot.org/uniprot/Q0AXU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyl-CoA hydrolase/transferase family.|||Coenzyme A-transferase that converts butyrate to butyryl-CoA.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS13295 ^@ http://purl.uniprot.org/uniprot/Q0ATU5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.|||Binds 1 potassium ion per subunit.|||Cytoplasm|||Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits. http://togogenome.org/gene/335541:SWOL_RS03600 ^@ http://purl.uniprot.org/uniprot/Q0AZ18 ^@ Similarity ^@ Belongs to the asparagine synthetase family. http://togogenome.org/gene/335541:SWOL_RS02880 ^@ http://purl.uniprot.org/uniprot/Q0AZF3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseB family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/335541:SWOL_RS10445 ^@ http://purl.uniprot.org/uniprot/Q0AVE0 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/335541:SWOL_RS12070 ^@ http://purl.uniprot.org/uniprot/Q0AUI3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/335541:SWOL_RS02700 ^@ http://purl.uniprot.org/uniprot/Q0AZI9 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/335541:SWOL_RS03870 ^@ http://purl.uniprot.org/uniprot/Q0AYW7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TmcAL family.|||Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS04910 ^@ http://purl.uniprot.org/uniprot/Q0AYC2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CobB/CobQ family. GatD subfamily.|||Forms a heterodimer with MurT.|||The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT. http://togogenome.org/gene/335541:SWOL_RS02315 ^@ http://purl.uniprot.org/uniprot/Q0AZR4 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/335541:SWOL_RS09995 ^@ http://purl.uniprot.org/uniprot/Q0AVM3 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thiolase-like superfamily. Thiolase family.|||Cytoplasm|||Highly expressed during syntrophic growth with butyrate (at protein level). Seems to be constitutively expressed.|||Involved in syntrophic growth of S.wolfei with butyrate, as part of the butyrate oxidation pathway. Probably catalyzes the beta-keto thiolysis of acetoacetyl-CoA, leading to 2 acetyl-CoA molecules. http://togogenome.org/gene/335541:SWOL_RS07490 ^@ http://purl.uniprot.org/uniprot/Q0AWZ8 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CheB family.|||Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.|||Cytoplasm|||Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.|||Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity. http://togogenome.org/gene/335541:SWOL_RS04995 ^@ http://purl.uniprot.org/uniprot/Q0AYA7 ^@ Similarity ^@ Belongs to the CbxX/CfxQ family. http://togogenome.org/gene/335541:SWOL_RS02775 ^@ http://purl.uniprot.org/uniprot/Q0AZH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/335541:SWOL_RS03380 ^@ http://purl.uniprot.org/uniprot/Q0AZ59 ^@ Function|||Similarity|||Subunit ^@ Belongs to the spermidine/spermine synthase family.|||Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.|||Homodimer or homotetramer. http://togogenome.org/gene/335541:SWOL_RS10235 ^@ http://purl.uniprot.org/uniprot/Q0AVH8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. N-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/335541:SWOL_RS11015 ^@ http://purl.uniprot.org/uniprot/Q0AV33 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/335541:SWOL_RS03290 ^@ http://purl.uniprot.org/uniprot/Q0AZ77 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/335541:SWOL_RS04345 ^@ http://purl.uniprot.org/uniprot/Q0AYM5 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliM family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS02375 ^@ http://purl.uniprot.org/uniprot/Q0AZQ1 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS12705 ^@ http://purl.uniprot.org/uniprot/Q0AU62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase D family. Cardiolipin synthase subfamily.|||Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS02290 ^@ http://purl.uniprot.org/uniprot/Q0AZR9 ^@ Caution|||Function|||Similarity ^@ Belongs to the aspartate/glutamate racemases family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Provides the (R)-glutamate required for cell wall biosynthesis. http://togogenome.org/gene/335541:SWOL_RS12770 ^@ http://purl.uniprot.org/uniprot/Q0AU49 ^@ Similarity ^@ Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/335541:SWOL_RS09560 ^@ http://purl.uniprot.org/uniprot/Q0AVV7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS00410 ^@ http://purl.uniprot.org/uniprot/Q0B0S9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Mg(2+) ion per subunit.|||Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.|||Cytoplasm|||Homotrimer.|||In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/335541:SWOL_RS02875 ^@ http://purl.uniprot.org/uniprot/Q0AZF4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseA family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/335541:SWOL_RS10925 ^@ http://purl.uniprot.org/uniprot/Q0AV50 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS00570 ^@ http://purl.uniprot.org/uniprot/Q0B0P6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/335541:SWOL_RS04245 ^@ http://purl.uniprot.org/uniprot/Q0AYP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmG family. TrmFO subfamily.|||Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS01680 ^@ http://purl.uniprot.org/uniprot/Q0B033 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS12060 ^@ http://purl.uniprot.org/uniprot/Q0AUI5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). http://togogenome.org/gene/335541:SWOL_RS00835 ^@ http://purl.uniprot.org/uniprot/Q0B0J5 ^@ Function|||Similarity ^@ Belongs to the transposase mutator family.|||Required for the transposition of the insertion element. http://togogenome.org/gene/335541:SWOL_RS11925 ^@ http://purl.uniprot.org/uniprot/Q0AUL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS08485 ^@ http://purl.uniprot.org/uniprot/Q0AWG3 ^@ Similarity ^@ Belongs to the UPF0758 family. http://togogenome.org/gene/335541:SWOL_RS09365 ^@ http://purl.uniprot.org/uniprot/Q0AVZ5 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS11860 ^@ http://purl.uniprot.org/uniprot/Q0AUM5 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. http://togogenome.org/gene/335541:SWOL_RS13160 ^@ http://purl.uniprot.org/uniprot/Q0ATX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP38/TMEM64 family.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS04200 ^@ http://purl.uniprot.org/uniprot/Q0AYQ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.|||Cell membrane|||Self-interacts. Interacts with FtsZ. http://togogenome.org/gene/335541:SWOL_RS01755 ^@ http://purl.uniprot.org/uniprot/Q0B017 ^@ Function|||Similarity ^@ ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.|||Belongs to the ParA family. MinD subfamily. http://togogenome.org/gene/335541:SWOL_RS03400 ^@ http://purl.uniprot.org/uniprot/Q0AZ55 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/335541:SWOL_RS04800 ^@ http://purl.uniprot.org/uniprot/Q0AYE4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS05250 ^@ http://purl.uniprot.org/uniprot/Q0AY56 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/335541:SWOL_RS09590 ^@ http://purl.uniprot.org/uniprot/Q0AVV1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/335541:SWOL_RS04100 ^@ http://purl.uniprot.org/uniprot/Q0AYS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).|||Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS01315 ^@ http://purl.uniprot.org/uniprot/Q0B0A1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. UvrA family.|||Cytoplasm|||Forms a heterotetramer with UvrB during the search for lesions.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. http://togogenome.org/gene/335541:SWOL_RS00550 ^@ http://purl.uniprot.org/uniprot/Q0B0Q0 ^@ Similarity ^@ Belongs to the DHPS family. http://togogenome.org/gene/335541:SWOL_RS10050 ^@ http://purl.uniprot.org/uniprot/Q0AVL2 ^@ Similarity ^@ Belongs to the FldB/FldC dehydratase alpha/beta subunit family. http://togogenome.org/gene/335541:SWOL_RS04905 ^@ http://purl.uniprot.org/uniprot/Q0AYC3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MurCDEF family. MurT subfamily.|||Forms a heterodimer with GatD.|||The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue. http://togogenome.org/gene/335541:SWOL_RS03555 ^@ http://purl.uniprot.org/uniprot/Q0AZ27 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/335541:SWOL_RS13100 ^@ http://purl.uniprot.org/uniprot/Q0ATY1 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/335541:SWOL_RS11210 ^@ http://purl.uniprot.org/uniprot/Q0AUZ4 ^@ Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family. http://togogenome.org/gene/335541:SWOL_RS03485 ^@ http://purl.uniprot.org/uniprot/Q0AZ40 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ALAD family.|||Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.|||Homooctamer. http://togogenome.org/gene/335541:SWOL_RS11960 ^@ http://purl.uniprot.org/uniprot/Q0AUK5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/335541:SWOL_RS03255 ^@ http://purl.uniprot.org/uniprot/Q0AZ83 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/335541:SWOL_RS13650 ^@ http://purl.uniprot.org/uniprot/Q0AW84 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS11120 ^@ http://purl.uniprot.org/uniprot/Q0AV12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS02670 ^@ http://purl.uniprot.org/uniprot/Q0AZJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0316 family.|||Cell membrane http://togogenome.org/gene/335541:SWOL_RS01590 ^@ http://purl.uniprot.org/uniprot/Q0B050 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS09480 ^@ http://purl.uniprot.org/uniprot/Q0AVX1 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/335541:SWOL_RS02220 ^@ http://purl.uniprot.org/uniprot/Q0AZT3 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/335541:SWOL_RS06330 ^@ http://purl.uniprot.org/uniprot/Q0AXL3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/335541:SWOL_RS11315 ^@ http://purl.uniprot.org/uniprot/Q0AUX3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HCP family.|||Binds 1 [4Fe-4S] cluster.|||Binds 1 hybrid [4Fe-2O-2S] cluster.|||Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS00100 ^@ http://purl.uniprot.org/uniprot/Q0B0Y1 ^@ Function|||Similarity ^@ Belongs to the RmuC family.|||Involved in DNA recombination. http://togogenome.org/gene/335541:SWOL_RS12110 ^@ http://purl.uniprot.org/uniprot/Q0AUH5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/335541:SWOL_RS06985 ^@ http://purl.uniprot.org/uniprot/Q0AX96 ^@ Function|||Similarity|||Subunit ^@ Catalyzes the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer).|||Homodimer.|||In the C-terminal section; belongs to the MurCDEF family. http://togogenome.org/gene/335541:SWOL_RS03125 ^@ http://purl.uniprot.org/uniprot/Q0AZA8 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/335541:SWOL_RS09925 ^@ http://purl.uniprot.org/uniprot/Q0AVN6 ^@ Similarity ^@ Belongs to the LytR/CpsA/Psr (LCP) family. http://togogenome.org/gene/335541:SWOL_RS07430 ^@ http://purl.uniprot.org/uniprot/Q0AX10 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS13000 ^@ http://purl.uniprot.org/uniprot/Q0AU00 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/335541:SWOL_RS04925 ^@ http://purl.uniprot.org/uniprot/Q0AYB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0291 family.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS04260 ^@ http://purl.uniprot.org/uniprot/Q0AYP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.|||Belongs to the ClpX chaperone family. HslU subfamily.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS04875 ^@ http://purl.uniprot.org/uniprot/Q0AYC9 ^@ Similarity ^@ Belongs to the EamA transporter family. http://togogenome.org/gene/335541:SWOL_RS02550 ^@ http://purl.uniprot.org/uniprot/Q0AZL7 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/335541:SWOL_RS10840 ^@ http://purl.uniprot.org/uniprot/Q0AV67 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily. http://togogenome.org/gene/335541:SWOL_RS06600 ^@ http://purl.uniprot.org/uniprot/Q0AXG1 ^@ Similarity ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. http://togogenome.org/gene/335541:SWOL_RS01295 ^@ http://purl.uniprot.org/uniprot/Q0B0A5 ^@ Similarity ^@ Belongs to the peptidase S41A family. http://togogenome.org/gene/335541:SWOL_RS06480 ^@ http://purl.uniprot.org/uniprot/Q0AXI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane|||This protein catalyzes the committed step to the synthesis of the acidic phospholipids. http://togogenome.org/gene/335541:SWOL_RS09185 ^@ http://purl.uniprot.org/uniprot/Q0AW32 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/335541:SWOL_RS04470 ^@ http://purl.uniprot.org/uniprot/Q0AYK0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS07470 ^@ http://purl.uniprot.org/uniprot/Q0AX02 ^@ Similarity ^@ Belongs to the Mg-chelatase subunits D/I family. ComM subfamily. http://togogenome.org/gene/335541:SWOL_RS10820 ^@ http://purl.uniprot.org/uniprot/Q0AV71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ArsB family.|||Belongs to the CitM (TC 2.A.11) transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS01025 ^@ http://purl.uniprot.org/uniprot/Q0B0F9 ^@ Similarity ^@ Belongs to the bacterial flagellin family. http://togogenome.org/gene/335541:SWOL_RS02920 ^@ http://purl.uniprot.org/uniprot/Q0AZE6 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/335541:SWOL_RS11870 ^@ http://purl.uniprot.org/uniprot/Q0AUM3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.|||Cytoplasm|||Heterotetramer of two alpha and two beta chains.|||Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway. http://togogenome.org/gene/335541:SWOL_RS06240 ^@ http://purl.uniprot.org/uniprot/Q0AXN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS11675 ^@ http://purl.uniprot.org/uniprot/Q0AUQ7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HsdR family.|||Subunit R is required for both nuclease and ATPase activities, but not for modification.|||The type I restriction/modification system is composed of three polypeptides R, M and S. http://togogenome.org/gene/335541:SWOL_RS04010 ^@ http://purl.uniprot.org/uniprot/Q0AYT9 ^@ Similarity ^@ Belongs to the HicA mRNA interferase family. http://togogenome.org/gene/335541:SWOL_RS06805 ^@ http://purl.uniprot.org/uniprot/Q0AXD0 ^@ Function|||Similarity ^@ Belongs to the 'phage' integrase family.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. http://togogenome.org/gene/335541:SWOL_RS07735 ^@ http://purl.uniprot.org/uniprot/Q0AWV7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/335541:SWOL_RS08160 ^@ http://purl.uniprot.org/uniprot/Q0AWM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. PrmA family.|||Cytoplasm|||Methylates ribosomal protein L11. http://togogenome.org/gene/335541:SWOL_RS01940 ^@ http://purl.uniprot.org/uniprot/Q0AZY5 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/335541:SWOL_RS00415 ^@ http://purl.uniprot.org/uniprot/Q0B0S8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/335541:SWOL_RS06620 ^@ http://purl.uniprot.org/uniprot/Q0AUU5 ^@ Similarity ^@ Belongs to the transposase IS21/IS408/IS1162 family. http://togogenome.org/gene/335541:SWOL_RS06555 ^@ http://purl.uniprot.org/uniprot/Q0AXH0 ^@ Function|||Similarity|||Subunit ^@ Associates with stalled 50S ribosomal subunits.|||Belongs to the NEMF family.|||Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits. http://togogenome.org/gene/335541:SWOL_RS10990 ^@ http://purl.uniprot.org/uniprot/Q0AV37 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/335541:SWOL_RS09150 ^@ http://purl.uniprot.org/uniprot/Q0AW39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS12435 ^@ http://purl.uniprot.org/uniprot/Q0AUB6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.|||Binds 1 zinc ion per subunit.|||Binds the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/335541:SWOL_RS01405 ^@ http://purl.uniprot.org/uniprot/Q0B085 ^@ Similarity ^@ Belongs to the SorC transcriptional regulatory family. http://togogenome.org/gene/335541:SWOL_RS11000 ^@ http://purl.uniprot.org/uniprot/Q0AV35 ^@ Similarity ^@ Belongs to the acetyl-CoA hydrolase/transferase family. http://togogenome.org/gene/335541:SWOL_RS12590 ^@ http://purl.uniprot.org/uniprot/Q0AU85 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.|||Cell membrane|||Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetI) and a solute-binding protein (MetQ). http://togogenome.org/gene/335541:SWOL_RS07660 ^@ http://purl.uniprot.org/uniprot/Q0AWX1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/335541:SWOL_RS12280 ^@ http://purl.uniprot.org/uniprot/Q0AUE7 ^@ Activity Regulation|||Function|||Similarity ^@ Appears to be allosterically activated by the binding of pArg-containing polypeptides to the pArg-binding pocket localized in the C-terminal domain of McsB.|||Belongs to the ATP:guanido phosphotransferase family.|||Catalyzes the specific phosphorylation of arginine residues in proteins. http://togogenome.org/gene/335541:SWOL_RS08090 ^@ http://purl.uniprot.org/uniprot/Q0AWN9 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/335541:SWOL_RS08775 ^@ http://purl.uniprot.org/uniprot/Q0AWA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/335541:SWOL_RS12090 ^@ http://purl.uniprot.org/uniprot/Q0AUH9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/335541:SWOL_RS02055 ^@ http://purl.uniprot.org/uniprot/Q0AZW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS10890 ^@ http://purl.uniprot.org/uniprot/Q0AV57 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/335541:SWOL_RS12535 ^@ http://purl.uniprot.org/uniprot/Q0AU95 ^@ Similarity ^@ Belongs to the RpoE family. http://togogenome.org/gene/335541:SWOL_RS00975 ^@ http://purl.uniprot.org/uniprot/Q0B0G8 ^@ Similarity ^@ Belongs to the UDP-N-acetylglucosamine 2-epimerase family. http://togogenome.org/gene/335541:SWOL_RS11920 ^@ http://purl.uniprot.org/uniprot/Q0AUL3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS01260 ^@ http://purl.uniprot.org/uniprot/Q0B0B2 ^@ Similarity ^@ Belongs to the MotB family. http://togogenome.org/gene/335541:SWOL_RS00665 ^@ http://purl.uniprot.org/uniprot/Q0B0M7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurJ/MviN family.|||Cell membrane|||Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.|||Membrane http://togogenome.org/gene/335541:SWOL_RS02090 ^@ http://purl.uniprot.org/uniprot/Q0AZV6 ^@ Similarity ^@ Belongs to the FldB/FldC dehydratase alpha/beta subunit family. http://togogenome.org/gene/335541:SWOL_RS04980 ^@ http://purl.uniprot.org/uniprot/Q0AYA9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Hfq family.|||Homohexamer.|||RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. http://togogenome.org/gene/335541:SWOL_RS04125 ^@ http://purl.uniprot.org/uniprot/Q0AYR6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MraZ family.|||Forms oligomers.|||nucleoid http://togogenome.org/gene/335541:SWOL_RS04795 ^@ http://purl.uniprot.org/uniprot/Q0AYE5 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. SigI subfamily.|||Cytoplasm|||Interacts with RsgI.|||Negatively regulated by the anti-sigma-I factor RsgI.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. http://togogenome.org/gene/335541:SWOL_RS00035 ^@ http://purl.uniprot.org/uniprot/Q0B0Z0 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/335541:SWOL_RS11100 ^@ http://purl.uniprot.org/uniprot/Q0AV16 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/335541:SWOL_RS11705 ^@ http://purl.uniprot.org/uniprot/Q0AUQ1 ^@ Similarity ^@ Belongs to the UPF0758 family. http://togogenome.org/gene/335541:SWOL_RS02440 ^@ http://purl.uniprot.org/uniprot/Q0AZN8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/335541:SWOL_RS03320 ^@ http://purl.uniprot.org/uniprot/Q0AZ71 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/335541:SWOL_RS04745 ^@ http://purl.uniprot.org/uniprot/Q0AYF5 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/335541:SWOL_RS11730 ^@ http://purl.uniprot.org/uniprot/Q0AUP6 ^@ Function|||Similarity ^@ Belongs to the 'phage' integrase family.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. http://togogenome.org/gene/335541:SWOL_RS10085 ^@ http://purl.uniprot.org/uniprot/Q0AVK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS01425 ^@ http://purl.uniprot.org/uniprot/Q0B081 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the BPG-independent phosphoglycerate mutase family.|||Binds 2 manganese ions per subunit.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.|||Monomer. http://togogenome.org/gene/335541:SWOL_RS10300 ^@ http://purl.uniprot.org/uniprot/Q0AVG5 ^@ Similarity ^@ Belongs to the SOS response-associated peptidase family. http://togogenome.org/gene/335541:SWOL_RS08085 ^@ http://purl.uniprot.org/uniprot/Q0AWP0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell membrane|||Cytoplasm|||Monomer. http://togogenome.org/gene/335541:SWOL_RS11065 ^@ http://purl.uniprot.org/uniprot/Q0AV23 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS09755 ^@ http://purl.uniprot.org/uniprot/Q0AVR9 ^@ Similarity ^@ Belongs to the sulfur carrier protein TusA family. http://togogenome.org/gene/335541:SWOL_RS02980 ^@ http://purl.uniprot.org/uniprot/Q0AZD7 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/335541:SWOL_RS11905 ^@ http://purl.uniprot.org/uniprot/Q0AUL6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/335541:SWOL_RS00310 ^@ http://purl.uniprot.org/uniprot/Q0B0U9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmI family.|||Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS05690 ^@ http://purl.uniprot.org/uniprot/Q0AXY1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.|||Cell membrane|||Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. http://togogenome.org/gene/335541:SWOL_RS00420 ^@ http://purl.uniprot.org/uniprot/Q0B0S7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/335541:SWOL_RS12995 ^@ http://purl.uniprot.org/uniprot/Q0AU01 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/335541:SWOL_RS12685 ^@ http://purl.uniprot.org/uniprot/Q0AU66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS04960 ^@ http://purl.uniprot.org/uniprot/Q0AYB3 ^@ Similarity ^@ Belongs to the histone deacetylase family. http://togogenome.org/gene/335541:SWOL_RS01575 ^@ http://purl.uniprot.org/uniprot/Q0B053 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/335541:SWOL_RS12100 ^@ http://purl.uniprot.org/uniprot/Q0AUH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS13285 ^@ http://purl.uniprot.org/uniprot/Q0ATU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Specifically methylates the N7 position of a guanine in 16S rRNA. http://togogenome.org/gene/335541:SWOL_RS09160 ^@ http://purl.uniprot.org/uniprot/Q0AW37 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATP phosphoribosyltransferase family. Short subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Heteromultimer composed of HisG and HisZ subunits.|||Lacks the C-terminal regulatory region which is replaced by HisZ. http://togogenome.org/gene/335541:SWOL_RS04495 ^@ http://purl.uniprot.org/uniprot/Q0AYJ5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspG family.|||Binds 1 [4Fe-4S] cluster.|||Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. http://togogenome.org/gene/335541:SWOL_RS09140 ^@ http://purl.uniprot.org/uniprot/Q0AW41 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/335541:SWOL_RS13500 ^@ http://purl.uniprot.org/uniprot/Q0AYN0 ^@ Similarity ^@ Belongs to the FlgD family. http://togogenome.org/gene/335541:SWOL_RS00140 ^@ http://purl.uniprot.org/uniprot/Q0B0X4 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily. http://togogenome.org/gene/335541:SWOL_RS00535 ^@ http://purl.uniprot.org/uniprot/Q0B0Q3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA(Ile)-lysidine synthase family.|||Cytoplasm|||Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.|||The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding. http://togogenome.org/gene/335541:SWOL_RS04385 ^@ http://purl.uniprot.org/uniprot/Q0AYL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.|||Cell membrane|||Membrane|||Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin. http://togogenome.org/gene/335541:SWOL_RS09645 ^@ http://purl.uniprot.org/uniprot/Q0AVT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acetylates the N-terminal alanine of ribosomal protein bS18.|||Belongs to the acetyltransferase family. RimI subfamily.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS07335 ^@ http://purl.uniprot.org/uniprot/Q0AX29 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ScpA family.|||Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.|||Cytoplasm|||Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. http://togogenome.org/gene/335541:SWOL_RS12510 ^@ http://purl.uniprot.org/uniprot/Q0AUA0 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/335541:SWOL_RS02475 ^@ http://purl.uniprot.org/uniprot/Q0AZN1 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/335541:SWOL_RS04590 ^@ http://purl.uniprot.org/uniprot/Q0AYH7 ^@ Function|||Similarity ^@ Belongs to the dUTPase family.|||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/335541:SWOL_RS09985 ^@ http://purl.uniprot.org/uniprot/Q0AVM5 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyl-CoA hydrolase/transferase family.|||Coenzyme A-transferase that converts butyrate to butyryl-CoA. Involved in the syntrophic growth of S.wolfei on butyrate in cooperation with methanogens or an appropriate hydrogen-scavenging bacterium, as part of the butyrate oxidation pathway.|||Cytoplasm|||Expressed during syntrophic growth with butyrate (at protein level). Seems to be constitutively expressed. http://togogenome.org/gene/335541:SWOL_RS01280 ^@ http://purl.uniprot.org/uniprot/Q0B0A8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Homodimer. Forms a membrane-associated complex with FtsX.|||Part of the ABC transporter FtsEX involved in cellular division. http://togogenome.org/gene/335541:SWOL_RS00590 ^@ http://purl.uniprot.org/uniprot/Q0B0P2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.|||Catalyzes the oxidation of L-aspartate to iminoaspartate.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS06845 ^@ http://purl.uniprot.org/uniprot/Q0AXC4 ^@ Function|||Subcellular Location Annotation ^@ ATPase. Has a role at an early stage in the morphogenesis of the spore coat.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS03535 ^@ http://purl.uniprot.org/uniprot/Q0AZ30 ^@ Similarity ^@ Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/335541:SWOL_RS06455 ^@ http://purl.uniprot.org/uniprot/Q0AXI9 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/335541:SWOL_RS06155 ^@ http://purl.uniprot.org/uniprot/Q0AXP6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the spermidine/spermine synthase family.|||Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.|||Homodimer or homotetramer. http://togogenome.org/gene/335541:SWOL_RS01035 ^@ http://purl.uniprot.org/uniprot/Q0B0F7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.|||Belongs to the FliW family.|||Cytoplasm|||Interacts with translational regulator CsrA and flagellin(s). http://togogenome.org/gene/335541:SWOL_RS05885 ^@ http://purl.uniprot.org/uniprot/Q0AXU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS01905 ^@ http://purl.uniprot.org/uniprot/Q0AZZ2 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/335541:SWOL_RS03715 ^@ http://purl.uniprot.org/uniprot/Q0AYZ6 ^@ Function|||Similarity ^@ Belongs to the 'phage' integrase family.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. http://togogenome.org/gene/335541:SWOL_RS13115 ^@ http://purl.uniprot.org/uniprot/Q0ATX8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6. http://togogenome.org/gene/335541:SWOL_RS04585 ^@ http://purl.uniprot.org/uniprot/Q0AYH8 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/335541:SWOL_RS13730 ^@ http://purl.uniprot.org/uniprot/Q0AVA0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS02385 ^@ http://purl.uniprot.org/uniprot/Q0AZP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YqgF nuclease family.|||Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS08285 ^@ http://purl.uniprot.org/uniprot/Q0AWK2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Iojap/RsfS family.|||Cytoplasm|||Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.|||Interacts with ribosomal protein uL14 (rplN). http://togogenome.org/gene/335541:SWOL_RS04190 ^@ http://purl.uniprot.org/uniprot/Q0AYQ4 ^@ Similarity ^@ Belongs to the UPF0749 family. http://togogenome.org/gene/335541:SWOL_RS10565 ^@ http://purl.uniprot.org/uniprot/Q0AVB8 ^@ Similarity|||Subunit ^@ Belongs to the MtrB family.|||Oligomer of 11 identical subunits arranged in doughnut-like structure. http://togogenome.org/gene/335541:SWOL_RS02180 ^@ http://purl.uniprot.org/uniprot/Q0AZT9 ^@ Similarity ^@ Belongs to the FldB/FldC dehydratase alpha/beta subunit family. http://togogenome.org/gene/335541:SWOL_RS11095 ^@ http://purl.uniprot.org/uniprot/Q0AV17 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/335541:SWOL_RS05150 ^@ http://purl.uniprot.org/uniprot/Q0AY76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyl-CoA hydrolase/transferase family.|||Coenzyme A-transferase that converts butyrate to butyryl-CoA.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS07845 ^@ http://purl.uniprot.org/uniprot/Q0AWT8 ^@ Function|||Similarity ^@ Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.|||Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. http://togogenome.org/gene/335541:SWOL_RS00600 ^@ http://purl.uniprot.org/uniprot/Q0B0P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BioY family.|||Cell membrane http://togogenome.org/gene/335541:SWOL_RS11080 ^@ http://purl.uniprot.org/uniprot/Q0AV20 ^@ Function|||Similarity|||Subunit ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.|||Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS04140 ^@ http://purl.uniprot.org/uniprot/Q0AYR4 ^@ Similarity ^@ Belongs to the transpeptidase family. http://togogenome.org/gene/335541:SWOL_RS12730 ^@ http://purl.uniprot.org/uniprot/Q0AU57 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS11285 ^@ http://purl.uniprot.org/uniprot/Q0AUX9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS09565 ^@ http://purl.uniprot.org/uniprot/Q0AVV6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.|||Homotetramer. http://togogenome.org/gene/335541:SWOL_RS09610 ^@ http://purl.uniprot.org/uniprot/Q0AVU7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/335541:SWOL_RS08935 ^@ http://purl.uniprot.org/uniprot/Q0AW75 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SbcD family.|||Heterodimer of SbcC and SbcD.|||SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity. http://togogenome.org/gene/335541:SWOL_RS02390 ^@ http://purl.uniprot.org/uniprot/Q0AZP8 ^@ Similarity ^@ Belongs to the UPF0473 family. http://togogenome.org/gene/335541:SWOL_RS12105 ^@ http://purl.uniprot.org/uniprot/Q0AUH6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/335541:SWOL_RS03880 ^@ http://purl.uniprot.org/uniprot/Q0AYW5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Cytoplasm|||Homodimer.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/335541:SWOL_RS07860 ^@ http://purl.uniprot.org/uniprot/Q0AWT5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/335541:SWOL_RS06070 ^@ http://purl.uniprot.org/uniprot/Q0AXR2 ^@ Similarity ^@ Belongs to the RelB/DinJ antitoxin family. http://togogenome.org/gene/335541:SWOL_RS12065 ^@ http://purl.uniprot.org/uniprot/Q0AUI4 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/335541:SWOL_RS04520 ^@ http://purl.uniprot.org/uniprot/Q0AYJ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/335541:SWOL_RS12550 ^@ http://purl.uniprot.org/uniprot/Q0AU92 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/335541:SWOL_RS08095 ^@ http://purl.uniprot.org/uniprot/Q0AWN8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial diacylglycerol kinase family.|||Membrane|||Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents. http://togogenome.org/gene/335541:SWOL_RS08940 ^@ http://purl.uniprot.org/uniprot/Q0AW74 ^@ Similarity ^@ Belongs to the peptidase S41A family. http://togogenome.org/gene/335541:SWOL_RS12025 ^@ http://purl.uniprot.org/uniprot/Q0AUJ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/335541:SWOL_RS05330 ^@ http://purl.uniprot.org/uniprot/Q0AY41 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS11255 ^@ http://purl.uniprot.org/uniprot/Q0AUY5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS09780 ^@ http://purl.uniprot.org/uniprot/Q0AVR4 ^@ Cofactor|||Similarity ^@ Belongs to the Fur family.|||Binds 1 Mn(2+) or Fe(2+) ion per subunit.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/335541:SWOL_RS11125 ^@ http://purl.uniprot.org/uniprot/Q0AV11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS01450 ^@ http://purl.uniprot.org/uniprot/Q0B076 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.|||Belongs to the RNR ribonuclease family. RNase R subfamily.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS03825 ^@ http://purl.uniprot.org/uniprot/Q0AYX4 ^@ Similarity ^@ Belongs to the asp23 family. http://togogenome.org/gene/335541:SWOL_RS01925 ^@ http://purl.uniprot.org/uniprot/Q0AZY8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/335541:SWOL_RS03310 ^@ http://purl.uniprot.org/uniprot/Q0AZ73 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS11525 ^@ http://purl.uniprot.org/uniprot/Q0AUT3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS08455 ^@ http://purl.uniprot.org/uniprot/Q0AWG9 ^@ Function|||Similarity ^@ ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.|||Belongs to the ParA family. MinD subfamily. http://togogenome.org/gene/335541:SWOL_RS01385 ^@ http://purl.uniprot.org/uniprot/Q0B089 ^@ Similarity ^@ Belongs to the ETF beta-subunit/FixA family. http://togogenome.org/gene/335541:SWOL_RS01675 ^@ http://purl.uniprot.org/uniprot/Q0B034 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS04915 ^@ http://purl.uniprot.org/uniprot/Q0AYC1 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/335541:SWOL_RS10805 ^@ http://purl.uniprot.org/uniprot/Q0AV74 ^@ Similarity ^@ Belongs to the sulfur carrier protein TusA family. http://togogenome.org/gene/335541:SWOL_RS05650 ^@ http://purl.uniprot.org/uniprot/Q0AXY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Cell membrane|||Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).|||In the C-terminal section; belongs to the transpeptidase family.|||In the N-terminal section; belongs to the glycosyltransferase 51 family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS03980 ^@ http://purl.uniprot.org/uniprot/Q0AYU5 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/335541:SWOL_RS04615 ^@ http://purl.uniprot.org/uniprot/Q0AYH2 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/335541:SWOL_RS00540 ^@ http://purl.uniprot.org/uniprot/Q0B0Q2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Homohexamer.|||In the C-terminal section; belongs to the peptidase M41 family.|||In the central section; belongs to the AAA ATPase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/335541:SWOL_RS12125 ^@ http://purl.uniprot.org/uniprot/Q0AUH2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/335541:SWOL_RS11980 ^@ http://purl.uniprot.org/uniprot/Q0AUK1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.|||Cytoplasm|||Monomer. http://togogenome.org/gene/335541:SWOL_RS11590 ^@ http://purl.uniprot.org/uniprot/Q0AUS2 ^@ Similarity ^@ Belongs to the UPF0145 family. http://togogenome.org/gene/335541:SWOL_RS08505 ^@ http://purl.uniprot.org/uniprot/Q0AWF9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS05945 ^@ http://purl.uniprot.org/uniprot/Q0AXT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0182 family.|||Cell membrane http://togogenome.org/gene/335541:SWOL_RS10600 ^@ http://purl.uniprot.org/uniprot/Q0AVB1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS07390 ^@ http://purl.uniprot.org/uniprot/Q0AX18 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueA family.|||Cytoplasm|||Monomer.|||Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). http://togogenome.org/gene/335541:SWOL_RS04150 ^@ http://purl.uniprot.org/uniprot/Q0AYR2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurF subfamily.|||Cytoplasm|||Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. http://togogenome.org/gene/335541:SWOL_RS02455 ^@ http://purl.uniprot.org/uniprot/Q0AUU4 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/335541:SWOL_RS01760 ^@ http://purl.uniprot.org/uniprot/Q0B016 ^@ Function|||Similarity ^@ Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.|||Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. http://togogenome.org/gene/335541:SWOL_RS05785 ^@ http://purl.uniprot.org/uniprot/Q0AXW4 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/335541:SWOL_RS03985 ^@ http://purl.uniprot.org/uniprot/Q0AYU4 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/335541:SWOL_RS11220 ^@ http://purl.uniprot.org/uniprot/Q0AUZ2 ^@ Similarity ^@ Belongs to the histone deacetylase family. http://togogenome.org/gene/335541:SWOL_RS08750 ^@ http://purl.uniprot.org/uniprot/Q0AWB3 ^@ Function|||Similarity ^@ Belongs to the MoeA family.|||Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.|||May be involved in the biosynthesis of molybdopterin. http://togogenome.org/gene/335541:SWOL_RS06990 ^@ http://purl.uniprot.org/uniprot/Q0AX95 ^@ Function|||Similarity ^@ Belongs to the peptidase S51 family.|||Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides. http://togogenome.org/gene/335541:SWOL_RS08475 ^@ http://purl.uniprot.org/uniprot/Q0AWG5 ^@ Function|||Similarity ^@ Belongs to the MreC family.|||Involved in formation and maintenance of cell shape. http://togogenome.org/gene/335541:SWOL_RS09210 ^@ http://purl.uniprot.org/uniprot/Q0AW27 ^@ Similarity ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. http://togogenome.org/gene/335541:SWOL_RS10310 ^@ http://purl.uniprot.org/uniprot/Q0AVG3 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/335541:SWOL_RS09070 ^@ http://purl.uniprot.org/uniprot/Q0AW54 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated Csm5 family.|||This subunit might be involved in maturation of a crRNA intermediate to its mature form. http://togogenome.org/gene/335541:SWOL_RS02190 ^@ http://purl.uniprot.org/uniprot/Q0AZT7 ^@ Similarity ^@ Belongs to the BlaI transcriptional regulatory family. http://togogenome.org/gene/335541:SWOL_RS12140 ^@ http://purl.uniprot.org/uniprot/Q0AUG9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/335541:SWOL_RS10910 ^@ http://purl.uniprot.org/uniprot/Q0AV53 ^@ Similarity ^@ Belongs to the EamA transporter family. http://togogenome.org/gene/335541:SWOL_RS11105 ^@ http://purl.uniprot.org/uniprot/Q0AV15 ^@ Function|||Similarity ^@ Acts on leucine, isoleucine and valine.|||Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/335541:SWOL_RS09655 ^@ http://purl.uniprot.org/uniprot/Q0AVT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TsaE family.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS05560 ^@ http://purl.uniprot.org/uniprot/Q0AY03 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/335541:SWOL_RS09165 ^@ http://purl.uniprot.org/uniprot/Q0AW36 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.|||Cytoplasm|||Heteromultimer composed of HisG and HisZ subunits.|||Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.|||This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one. http://togogenome.org/gene/335541:SWOL_RS01380 ^@ http://purl.uniprot.org/uniprot/Q0B090 ^@ Cofactor|||Similarity ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer. http://togogenome.org/gene/335541:SWOL_RS01855 ^@ http://purl.uniprot.org/uniprot/Q0B002 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/335541:SWOL_RS11010 ^@ http://purl.uniprot.org/uniprot/Q0AV34 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/335541:SWOL_RS06595 ^@ http://purl.uniprot.org/uniprot/Q0AXG2 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/335541:SWOL_RS00950 ^@ http://purl.uniprot.org/uniprot/Q0B0H3 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/335541:SWOL_RS05175 ^@ http://purl.uniprot.org/uniprot/Q0AY71 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/335541:SWOL_RS13095 ^@ http://purl.uniprot.org/uniprot/Q0ATY2 ^@ Similarity ^@ Belongs to the peptidase S16 family. http://togogenome.org/gene/335541:SWOL_RS11880 ^@ http://purl.uniprot.org/uniprot/Q0AUM1 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/335541:SWOL_RS02860 ^@ http://purl.uniprot.org/uniprot/Q0AZF7 ^@ Function|||Similarity ^@ Belongs to the NusB family.|||Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. http://togogenome.org/gene/335541:SWOL_RS04510 ^@ http://purl.uniprot.org/uniprot/Q0AYJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-C family. PolC subfamily.|||Cytoplasm|||Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/335541:SWOL_RS13315 ^@ http://purl.uniprot.org/uniprot/Q0ATU2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RnpA family.|||Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.|||RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. http://togogenome.org/gene/335541:SWOL_RS12540 ^@ http://purl.uniprot.org/uniprot/Q0AU94 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/335541:SWOL_RS10680 ^@ http://purl.uniprot.org/uniprot/Q0AV96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS06545 ^@ http://purl.uniprot.org/uniprot/Q0AXH2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DapB family.|||Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.|||Cytoplasm|||Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. http://togogenome.org/gene/335541:SWOL_RS05575 ^@ http://purl.uniprot.org/uniprot/Q0AY00 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/335541:SWOL_RS06610 ^@ http://purl.uniprot.org/uniprot/Q0AXF9 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/335541:SWOL_RS12165 ^@ http://purl.uniprot.org/uniprot/Q0AUG4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/335541:SWOL_RS13280 ^@ http://purl.uniprot.org/uniprot/Q0ATU8 ^@ Similarity ^@ Belongs to the ParB family. http://togogenome.org/gene/335541:SWOL_RS04465 ^@ http://purl.uniprot.org/uniprot/Q0AYK1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/335541:SWOL_RS01040 ^@ http://purl.uniprot.org/uniprot/Q0B0F6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.|||Belongs to the CsrA/RsmA family.|||Cytoplasm|||Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core. http://togogenome.org/gene/335541:SWOL_RS02235 ^@ http://purl.uniprot.org/uniprot/Q0AZT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyl-CoA hydrolase/transferase family.|||Coenzyme A-transferase that converts butyrate to butyryl-CoA.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS03265 ^@ http://purl.uniprot.org/uniprot/Q0AZ81 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/335541:SWOL_RS10900 ^@ http://purl.uniprot.org/uniprot/Q0AV55 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.|||Could methylate the ribose at the nucleotide 34 wobble position in tRNA.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/335541:SWOL_RS07955 ^@ http://purl.uniprot.org/uniprot/Q0AWR6 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/335541:SWOL_RS03370 ^@ http://purl.uniprot.org/uniprot/Q0AZ61 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/335541:SWOL_RS11930 ^@ http://purl.uniprot.org/uniprot/Q0AUL1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.|||Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.|||Cell membrane|||Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component). http://togogenome.org/gene/335541:SWOL_RS03315 ^@ http://purl.uniprot.org/uniprot/Q0AZ72 ^@ Similarity ^@ Belongs to the UPF0342 family. http://togogenome.org/gene/335541:SWOL_RS08560 ^@ http://purl.uniprot.org/uniprot/Q0AWE9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/335541:SWOL_RS00635 ^@ http://purl.uniprot.org/uniprot/Q0B0N3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 3 Mg(2+) ions per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS01920 ^@ http://purl.uniprot.org/uniprot/Q0AZY9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/335541:SWOL_RS03375 ^@ http://purl.uniprot.org/uniprot/Q0AZ60 ^@ Similarity ^@ Belongs to the pyruvoyl-dependent arginine decarboxylase family. http://togogenome.org/gene/335541:SWOL_RS12345 ^@ http://purl.uniprot.org/uniprot/Q0AUD4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/335541:SWOL_RS09830 ^@ http://purl.uniprot.org/uniprot/Q0AVQ4 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/335541:SWOL_RS06140 ^@ http://purl.uniprot.org/uniprot/Q0AXP9 ^@ Cofactor|||Function|||Subunit ^@ Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.|||Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/335541:SWOL_RS09765 ^@ http://purl.uniprot.org/uniprot/Q0AVR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS01750 ^@ http://purl.uniprot.org/uniprot/Q0B018 ^@ Function|||Similarity ^@ Belongs to the MinE family.|||Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. http://togogenome.org/gene/335541:SWOL_RS04975 ^@ http://purl.uniprot.org/uniprot/Q0AYB0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).|||Monomer. http://togogenome.org/gene/335541:SWOL_RS08195 ^@ http://purl.uniprot.org/uniprot/Q0AWL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/335541:SWOL_RS11655 ^@ http://purl.uniprot.org/uniprot/Q0AUR1 ^@ Function|||Similarity ^@ Belongs to the 'phage' integrase family.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. http://togogenome.org/gene/335541:SWOL_RS11875 ^@ http://purl.uniprot.org/uniprot/Q0AUM2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS11505 ^@ http://purl.uniprot.org/uniprot/Q0AUT7 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/335541:SWOL_RS08170 ^@ http://purl.uniprot.org/uniprot/Q0AWM3 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/335541:SWOL_RS03450 ^@ http://purl.uniprot.org/uniprot/Q0AZ45 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatA/E family.|||Cell membrane|||Forms a complex with TatC.|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. http://togogenome.org/gene/335541:SWOL_RS05995 ^@ http://purl.uniprot.org/uniprot/Q0AXS4 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/335541:SWOL_RS12275 ^@ http://purl.uniprot.org/uniprot/Q0AUE8 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/335541:SWOL_RS08145 ^@ http://purl.uniprot.org/uniprot/Q0AWM8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/335541:SWOL_RS05740 ^@ http://purl.uniprot.org/uniprot/Q0AXX2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prokaryotic Ku family.|||Homodimer. Interacts with LigD.|||With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. http://togogenome.org/gene/335541:SWOL_RS09215 ^@ http://purl.uniprot.org/uniprot/Q0AW26 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/335541:SWOL_RS12325 ^@ http://purl.uniprot.org/uniprot/Q0AUD8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/335541:SWOL_RS02990 ^@ http://purl.uniprot.org/uniprot/Q0AZD5 ^@ Cofactor|||Function|||Subcellular Location Annotation ^@ Binds 1 Ca(2+) ion per subunit.|||Cytoplasm|||May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/335541:SWOL_RS05460 ^@ http://purl.uniprot.org/uniprot/Q0AY20 ^@ Similarity ^@ Belongs to the RelB/DinJ antitoxin family. http://togogenome.org/gene/335541:SWOL_RS04160 ^@ http://purl.uniprot.org/uniprot/Q0AYR0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS07410 ^@ http://purl.uniprot.org/uniprot/Q0AX14 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvC family.|||Binds 2 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA. http://togogenome.org/gene/335541:SWOL_RS01220 ^@ http://purl.uniprot.org/uniprot/Q0B0C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FliS family.|||cytosol http://togogenome.org/gene/335541:SWOL_RS01250 ^@ http://purl.uniprot.org/uniprot/Q0B0B4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell membrane|||Cytoplasm|||May bind 1 zinc ion per subunit.|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/335541:SWOL_RS07725 ^@ http://purl.uniprot.org/uniprot/Q0AWV9 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/335541:SWOL_RS07290 ^@ http://purl.uniprot.org/uniprot/Q0AX38 ^@ Similarity ^@ Belongs to the formate--tetrahydrofolate ligase family. http://togogenome.org/gene/335541:SWOL_RS00015 ^@ http://purl.uniprot.org/uniprot/Q0B0Z4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DnaA family.|||Cytoplasm|||Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. http://togogenome.org/gene/335541:SWOL_RS06290 ^@ http://purl.uniprot.org/uniprot/Q0AXM1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/335541:SWOL_RS03420 ^@ http://purl.uniprot.org/uniprot/Q0AZ51 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/335541:SWOL_RS00435 ^@ http://purl.uniprot.org/uniprot/Q0B0S3 ^@ Similarity ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family. http://togogenome.org/gene/335541:SWOL_RS07785 ^@ http://purl.uniprot.org/uniprot/Q0AWU6 ^@ Similarity ^@ Belongs to the UPF0178 family. http://togogenome.org/gene/335541:SWOL_RS13205 ^@ http://purl.uniprot.org/uniprot/Q0ATW3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS06520 ^@ http://purl.uniprot.org/uniprot/Q0AXH7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.|||Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.|||Cytoplasm|||Homodimer, may be a subunit of the RNA degradosome. http://togogenome.org/gene/335541:SWOL_RS07295 ^@ http://purl.uniprot.org/uniprot/Q0AX37 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/335541:SWOL_RS07345 ^@ http://purl.uniprot.org/uniprot/Q0AX27 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/335541:SWOL_RS04550 ^@ http://purl.uniprot.org/uniprot/Q0AYI5 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.|||Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/335541:SWOL_RS12080 ^@ http://purl.uniprot.org/uniprot/Q0AUI1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/335541:SWOL_RS09555 ^@ http://purl.uniprot.org/uniprot/Q0AVV8 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/335541:SWOL_RS02350 ^@ http://purl.uniprot.org/uniprot/Q0AZQ7 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/335541:SWOL_RS09810 ^@ http://purl.uniprot.org/uniprot/Q0AVQ8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/335541:SWOL_RS02120 ^@ http://purl.uniprot.org/uniprot/Q0AZV1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS03040 ^@ http://purl.uniprot.org/uniprot/Q0AZC5 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/335541:SWOL_RS04450 ^@ http://purl.uniprot.org/uniprot/Q0AYK4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/335541:SWOL_RS07760 ^@ http://purl.uniprot.org/uniprot/Q0AWV2 ^@ Function|||Similarity ^@ Belongs to the UPF0122 family.|||Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein. http://togogenome.org/gene/335541:SWOL_RS00710 ^@ http://purl.uniprot.org/uniprot/Q0B0L8 ^@ Similarity ^@ Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. Anti-sigma-W factor family. http://togogenome.org/gene/335541:SWOL_RS11465 ^@ http://purl.uniprot.org/uniprot/Q0AUU5 ^@ Similarity ^@ Belongs to the transposase IS21/IS408/IS1162 family. http://togogenome.org/gene/335541:SWOL_RS09445 ^@ http://purl.uniprot.org/uniprot/Q0AVX8 ^@ Similarity ^@ Belongs to the complex I 51 kDa subunit family. http://togogenome.org/gene/335541:SWOL_RS09190 ^@ http://purl.uniprot.org/uniprot/Q0AW31 ^@ Domain|||Similarity ^@ Belongs to the PurH family.|||The IMP cyclohydrolase activity resides in the N-terminal region. http://togogenome.org/gene/335541:SWOL_RS00485 ^@ http://purl.uniprot.org/uniprot/Q0B0R4 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/335541:SWOL_RS04170 ^@ http://purl.uniprot.org/uniprot/Q0AYQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family. MurG subfamily.|||Cell membrane|||Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II). http://togogenome.org/gene/335541:SWOL_RS11500 ^@ http://purl.uniprot.org/uniprot/Q0AUT8 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/335541:SWOL_RS04305 ^@ http://purl.uniprot.org/uniprot/Q0AYN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FliJ family.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS10500 ^@ http://purl.uniprot.org/uniprot/Q0AVC9 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/335541:SWOL_RS06120 ^@ http://purl.uniprot.org/uniprot/Q0AXQ3 ^@ Similarity ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family. http://togogenome.org/gene/335541:SWOL_RS00585 ^@ http://purl.uniprot.org/uniprot/Q0B0P3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the quinolinate synthase family. Type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS01205 ^@ http://purl.uniprot.org/uniprot/Q0B0C3 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/335541:SWOL_RS09520 ^@ http://purl.uniprot.org/uniprot/Q0AVW5 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/335541:SWOL_RS06345 ^@ http://purl.uniprot.org/uniprot/Q0AXL0 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/335541:SWOL_RS10790 ^@ http://purl.uniprot.org/uniprot/Q0AV77 ^@ Function|||Similarity ^@ Belongs to the RecD family. RecD-like subfamily.|||DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity. http://togogenome.org/gene/335541:SWOL_RS06820 ^@ http://purl.uniprot.org/uniprot/Q0AXC8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily.|||Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS12250 ^@ http://purl.uniprot.org/uniprot/Q0AUF3 ^@ Similarity ^@ Belongs to the ycf81 family. http://togogenome.org/gene/335541:SWOL_RS12795 ^@ http://purl.uniprot.org/uniprot/Q0AU44 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS08175 ^@ http://purl.uniprot.org/uniprot/Q0AWM2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/335541:SWOL_RS04880 ^@ http://purl.uniprot.org/uniprot/Q0AYC8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/335541:SWOL_RS07370 ^@ http://purl.uniprot.org/uniprot/Q0AX22 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Cell membrane|||Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/335541:SWOL_RS04265 ^@ http://purl.uniprot.org/uniprot/Q0AYP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CodY family.|||Cytoplasm|||DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability. During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion. http://togogenome.org/gene/335541:SWOL_RS10615 ^@ http://purl.uniprot.org/uniprot/Q0AVA9 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/335541:SWOL_RS08100 ^@ http://purl.uniprot.org/uniprot/Q0AWN7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endoribonuclease YbeY family.|||Binds 1 zinc ion.|||Cytoplasm|||Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. http://togogenome.org/gene/335541:SWOL_RS03500 ^@ http://purl.uniprot.org/uniprot/Q0AZ37 ^@ Similarity ^@ Belongs to the Ahb/Nir family. http://togogenome.org/gene/335541:SWOL_RS12170 ^@ http://purl.uniprot.org/uniprot/Q0AUG3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/335541:SWOL_RS06955 ^@ http://purl.uniprot.org/uniprot/Q0AXA2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspH family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. http://togogenome.org/gene/335541:SWOL_RS09050 ^@ http://purl.uniprot.org/uniprot/Q0AW58 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/335541:SWOL_RS04830 ^@ http://purl.uniprot.org/uniprot/Q0AYD8 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/335541:SWOL_RS08200 ^@ http://purl.uniprot.org/uniprot/Q0AWL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurJ/MviN family.|||Cell membrane|||Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.|||Membrane http://togogenome.org/gene/335541:SWOL_RS06285 ^@ http://purl.uniprot.org/uniprot/Q0AXM2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit.|||Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. http://togogenome.org/gene/335541:SWOL_RS03820 ^@ http://purl.uniprot.org/uniprot/Q0AYX5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/335541:SWOL_RS11250 ^@ http://purl.uniprot.org/uniprot/Q0AUY6 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/335541:SWOL_RS01155 ^@ http://purl.uniprot.org/uniprot/Q0B0D3 ^@ Similarity ^@ Belongs to the HicA mRNA interferase family. http://togogenome.org/gene/335541:SWOL_RS04500 ^@ http://purl.uniprot.org/uniprot/Q0AYJ4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.|||Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS03860 ^@ http://purl.uniprot.org/uniprot/Q0AYW8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/335541:SWOL_RS12245 ^@ http://purl.uniprot.org/uniprot/Q0AUF4 ^@ Function|||Similarity ^@ Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.|||Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). http://togogenome.org/gene/335541:SWOL_RS03240 ^@ http://purl.uniprot.org/uniprot/Q0AZ86 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the thiamine-phosphate synthase family.|||Binds 1 Mg(2+) ion per subunit.|||Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). http://togogenome.org/gene/335541:SWOL_RS12700 ^@ http://purl.uniprot.org/uniprot/Q0AU63 ^@ Similarity ^@ Belongs to the beta-class carbonic anhydrase family. http://togogenome.org/gene/335541:SWOL_RS02490 ^@ http://purl.uniprot.org/uniprot/Q0AZM8 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/335541:SWOL_RS13125 ^@ http://purl.uniprot.org/uniprot/Q0ATX6 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with bS18 to 16S ribosomal RNA. http://togogenome.org/gene/335541:SWOL_RS11165 ^@ http://purl.uniprot.org/uniprot/Q0AV03 ^@ Similarity ^@ Belongs to the PTPS family. QueD subfamily. http://togogenome.org/gene/335541:SWOL_RS12055 ^@ http://purl.uniprot.org/uniprot/Q0AUI6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/335541:SWOL_RS13005 ^@ http://purl.uniprot.org/uniprot/Q0ATZ9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/335541:SWOL_RS07340 ^@ http://purl.uniprot.org/uniprot/Q0AX28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS04535 ^@ http://purl.uniprot.org/uniprot/Q0AYI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/335541:SWOL_RS03900 ^@ http://purl.uniprot.org/uniprot/Q0AYW1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS05305 ^@ http://purl.uniprot.org/uniprot/Q0AY46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS08155 ^@ http://purl.uniprot.org/uniprot/Q0AWM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/335541:SWOL_RS00990 ^@ http://purl.uniprot.org/uniprot/Q0B0G6 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/335541:SWOL_RS06280 ^@ http://purl.uniprot.org/uniprot/Q0AXM3 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion.|||Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.|||In the C-terminal section; belongs to the HTP reductase family.|||In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/335541:SWOL_RS04645 ^@ http://purl.uniprot.org/uniprot/Q0AYG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AzlC family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS02660 ^@ http://purl.uniprot.org/uniprot/Q0AZJ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the shikimate dehydrogenase family.|||Homodimer.|||Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). http://togogenome.org/gene/335541:SWOL_RS09320 ^@ http://purl.uniprot.org/uniprot/Q0AW04 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/335541:SWOL_RS10560 ^@ http://purl.uniprot.org/uniprot/Q0AVB9 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/335541:SWOL_RS10670 ^@ http://purl.uniprot.org/uniprot/Q0AV98 ^@ Similarity ^@ Belongs to the anti-sigma-factor antagonist family. http://togogenome.org/gene/335541:SWOL_RS03725 ^@ http://purl.uniprot.org/uniprot/Q0AYZ4 ^@ Function|||Similarity ^@ Belongs to the 'phage' integrase family.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. http://togogenome.org/gene/335541:SWOL_RS05775 ^@ http://purl.uniprot.org/uniprot/Q0AXW6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. http://togogenome.org/gene/335541:SWOL_RS06355 ^@ http://purl.uniprot.org/uniprot/Q0AXK8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylate kinase family.|||Cytoplasm|||Essential for recycling GMP and indirectly, cGMP. http://togogenome.org/gene/335541:SWOL_RS09550 ^@ http://purl.uniprot.org/uniprot/Q0AVV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thioester dehydratase family. FabZ subfamily.|||Cytoplasm|||Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. http://togogenome.org/gene/335541:SWOL_RS01660 ^@ http://purl.uniprot.org/uniprot/Q0B038 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS08705 ^@ http://purl.uniprot.org/uniprot/Q0AWC2 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily. http://togogenome.org/gene/335541:SWOL_RS13235 ^@ http://purl.uniprot.org/uniprot/Q0ATV7 ^@ Function ^@ Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP. http://togogenome.org/gene/335541:SWOL_RS11070 ^@ http://purl.uniprot.org/uniprot/Q0AV22 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/335541:SWOL_RS02610 ^@ http://purl.uniprot.org/uniprot/Q0AZK4 ^@ Similarity ^@ Belongs to the HsdR family. http://togogenome.org/gene/335541:SWOL_RS11530 ^@ http://purl.uniprot.org/uniprot/Q0AUT2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS12495 ^@ http://purl.uniprot.org/uniprot/Q0AUA4 ^@ Cofactor ^@ Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. http://togogenome.org/gene/335541:SWOL_RS11205 ^@ http://purl.uniprot.org/uniprot/Q0AUZ5 ^@ Similarity ^@ Belongs to the hemerythrin family. http://togogenome.org/gene/335541:SWOL_RS03145 ^@ http://purl.uniprot.org/uniprot/Q0AZA4 ^@ Similarity ^@ Belongs to the HicA mRNA interferase family. http://togogenome.org/gene/335541:SWOL_RS02685 ^@ http://purl.uniprot.org/uniprot/Q0AZJ1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.|||Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).|||Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS02910 ^@ http://purl.uniprot.org/uniprot/Q0AZE8 ^@ Similarity ^@ Belongs to the HicA mRNA interferase family. http://togogenome.org/gene/335541:SWOL_RS12425 ^@ http://purl.uniprot.org/uniprot/Q0AUB8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/335541:SWOL_RS12605 ^@ http://purl.uniprot.org/uniprot/Q0AU82 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/335541:SWOL_RS02680 ^@ http://purl.uniprot.org/uniprot/Q0AZJ2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shikimate kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/335541:SWOL_RS02460 ^@ http://purl.uniprot.org/uniprot/Q0AUU5 ^@ Similarity ^@ Belongs to the transposase IS21/IS408/IS1162 family. http://togogenome.org/gene/335541:SWOL_RS01375 ^@ http://purl.uniprot.org/uniprot/Q0B091 ^@ Similarity ^@ Belongs to the sigma-54 factor family. http://togogenome.org/gene/335541:SWOL_RS02760 ^@ http://purl.uniprot.org/uniprot/Q0AZH7 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/335541:SWOL_RS12360 ^@ http://purl.uniprot.org/uniprot/Q0AUD1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/335541:SWOL_RS05685 ^@ http://purl.uniprot.org/uniprot/Q0AXY2 ^@ Similarity ^@ Belongs to the thymidine kinase family. http://togogenome.org/gene/335541:SWOL_RS08845 ^@ http://purl.uniprot.org/uniprot/Q0AW94 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS00185 ^@ http://purl.uniprot.org/uniprot/Q0B0W5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DnaX/STICHEL family.|||DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/335541:SWOL_RS05525 ^@ http://purl.uniprot.org/uniprot/Q0AY08 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/335541:SWOL_RS12015 ^@ http://purl.uniprot.org/uniprot/Q0AUJ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/335541:SWOL_RS08070 ^@ http://purl.uniprot.org/uniprot/Q0AWP3 ^@ Function|||Similarity ^@ Belongs to the RecO family.|||Involved in DNA repair and RecF pathway recombination. http://togogenome.org/gene/335541:SWOL_RS00340 ^@ http://purl.uniprot.org/uniprot/Q0B0U3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/335541:SWOL_RS08400 ^@ http://purl.uniprot.org/uniprot/Q0AWH9 ^@ Similarity ^@ Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/335541:SWOL_RS09540 ^@ http://purl.uniprot.org/uniprot/Q0AVW1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccA family.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS06435 ^@ http://purl.uniprot.org/uniprot/Q0AVI1 ^@ Similarity ^@ Belongs to the bacterial reverse transcriptase family. http://togogenome.org/gene/335541:SWOL_RS00060 ^@ http://purl.uniprot.org/uniprot/Q0B0Y5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/335541:SWOL_RS11940 ^@ http://purl.uniprot.org/uniprot/Q0AUK9 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/335541:SWOL_RS02305 ^@ http://purl.uniprot.org/uniprot/Q0AZR6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNase PH family.|||Homohexameric ring arranged as a trimer of dimers.|||Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. http://togogenome.org/gene/335541:SWOL_RS06125 ^@ http://purl.uniprot.org/uniprot/Q0AXQ2 ^@ Similarity ^@ Belongs to the GerABKC lipoprotein family. http://togogenome.org/gene/335541:SWOL_RS04275 ^@ http://purl.uniprot.org/uniprot/Q0AYN8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family.|||The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each. http://togogenome.org/gene/335541:SWOL_RS12485 ^@ http://purl.uniprot.org/uniprot/Q0AUA6 ^@ Similarity ^@ Belongs to the FBPase class 2 family. http://togogenome.org/gene/335541:SWOL_RS13400 ^@ http://purl.uniprot.org/uniprot/Q0B0G0 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum|||Belongs to the flagella basal body rod proteins family.|||Secreted http://togogenome.org/gene/335541:SWOL_RS01955 ^@ http://purl.uniprot.org/uniprot/Q0AZY2 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/335541:SWOL_RS06130 ^@ http://purl.uniprot.org/uniprot/Q0AXQ1 ^@ Similarity ^@ Belongs to the GerABKA family. http://togogenome.org/gene/335541:SWOL_RS03445 ^@ http://purl.uniprot.org/uniprot/Q0AZ46 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Forms a complex with TatA.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/335541:SWOL_RS03525 ^@ http://purl.uniprot.org/uniprot/Q0AZ32 ^@ Cofactor|||Function|||Induction|||Subcellular Location Annotation|||Subunit ^@ Binds 2 [4Fe-4S] clusters per subunit.|||Cell membrane|||Highly expressed during syntrophic growth with butyrate (at protein level) (PubMed:19648244, PubMed:23468890). Seems to be constitutively expressed (PubMed:23468890).|||Might constitute a membrane-associated complex with EtfA (Swol_0697), EtfB (Swol_0696), and the butyryl-CoA dehydrogenase Swol_1933 and/or Swol_2052.|||Oxidoreductase involved in syntrophic growth of S.wolfei with butyrate. Is presumed to link the electron flow from butyryl-CoA dehydrogenases to the membrane, in conjunction with the electron transfer flavoprotein EtfAB. May transfer electrons to the menaquinone pool of the membrane. http://togogenome.org/gene/335541:SWOL_RS04950 ^@ http://purl.uniprot.org/uniprot/Q0AYB5 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. http://togogenome.org/gene/335541:SWOL_RS11085 ^@ http://purl.uniprot.org/uniprot/Q0AV19 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH or NADH to yield (R)-2,3-dihydroxy-isovalerate. http://togogenome.org/gene/335541:SWOL_RS07405 ^@ http://purl.uniprot.org/uniprot/Q0AX15 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvA family.|||Cytoplasm|||Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.|||Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA. http://togogenome.org/gene/335541:SWOL_RS11915 ^@ http://purl.uniprot.org/uniprot/Q0AUL4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS09055 ^@ http://purl.uniprot.org/uniprot/Q0AW57 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/335541:SWOL_RS02400 ^@ http://purl.uniprot.org/uniprot/Q0AZP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transglycosylase MltG family.|||Cell membrane|||Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. http://togogenome.org/gene/335541:SWOL_RS08640 ^@ http://purl.uniprot.org/uniprot/Q0AWD5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MscL family.|||Cell membrane|||Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.|||Homopentamer. http://togogenome.org/gene/335541:SWOL_RS02415 ^@ http://purl.uniprot.org/uniprot/Q0AZP3 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated protein Cas5 family. Subtype I-C/Dvulg subfamily.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/335541:SWOL_RS04965 ^@ http://purl.uniprot.org/uniprot/Q0AYB2 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/335541:SWOL_RS04480 ^@ http://purl.uniprot.org/uniprot/Q0AYJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS11135 ^@ http://purl.uniprot.org/uniprot/Q0AV09 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/335541:SWOL_RS13210 ^@ http://purl.uniprot.org/uniprot/Q0ATW2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS07645 ^@ http://purl.uniprot.org/uniprot/Q0AWX4 ^@ Similarity ^@ Belongs to the UPF0102 family. http://togogenome.org/gene/335541:SWOL_RS05550 ^@ http://purl.uniprot.org/uniprot/Q0AY05 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS04215 ^@ http://purl.uniprot.org/uniprot/Q0AYP9 ^@ Function|||Similarity ^@ Belongs to the sigma-70 factor family.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. http://togogenome.org/gene/335541:SWOL_RS08465 ^@ http://purl.uniprot.org/uniprot/Q0AWG7 ^@ Similarity ^@ Belongs to the transpeptidase family. http://togogenome.org/gene/335541:SWOL_RS12400 ^@ http://purl.uniprot.org/uniprot/Q0AUC3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS12150 ^@ http://purl.uniprot.org/uniprot/Q0AUG7 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/335541:SWOL_RS03425 ^@ http://purl.uniprot.org/uniprot/Q0AZ50 ^@ Similarity ^@ Belongs to the UbiD family. http://togogenome.org/gene/335541:SWOL_RS05870 ^@ http://purl.uniprot.org/uniprot/Q0AXU8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. AddA subfamily.|||Heterodimer of AddA and AddB/RexB.|||The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities. http://togogenome.org/gene/335541:SWOL_RS01900 ^@ http://purl.uniprot.org/uniprot/Q0AZZ3 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/335541:SWOL_RS10865 ^@ http://purl.uniprot.org/uniprot/Q0AV62 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. http://togogenome.org/gene/335541:SWOL_RS00525 ^@ http://purl.uniprot.org/uniprot/Q0B0Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNT transporter (TC 2.A.44) family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS01390 ^@ http://purl.uniprot.org/uniprot/Q0B088 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/335541:SWOL_RS07455 ^@ http://purl.uniprot.org/uniprot/Q0AX05 ^@ Function|||Similarity ^@ Belongs to the vitamin-B12 dependent methionine synthase family.|||Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. http://togogenome.org/gene/335541:SWOL_RS05845 ^@ http://purl.uniprot.org/uniprot/Q0AXV2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the helicase family. AddB/RexB type 1 subfamily.|||Binds 1 [4Fe-4S] cluster.|||Heterodimer of AddA and AddB.|||The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity. http://togogenome.org/gene/335541:SWOL_RS02450 ^@ http://purl.uniprot.org/uniprot/Q0AZN6 ^@ Similarity ^@ Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family. http://togogenome.org/gene/335541:SWOL_RS08190 ^@ http://purl.uniprot.org/uniprot/Q0AWM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||Cytoplasm|||Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/335541:SWOL_RS12300 ^@ http://purl.uniprot.org/uniprot/Q0AUE3 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily.|||Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid. http://togogenome.org/gene/335541:SWOL_RS10940 ^@ http://purl.uniprot.org/uniprot/Q0AV47 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase H family.|||Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Monomer. http://togogenome.org/gene/335541:SWOL_RS06460 ^@ http://purl.uniprot.org/uniprot/Q0AXI8 ^@ Similarity ^@ Belongs to the CinA family. http://togogenome.org/gene/335541:SWOL_RS11885 ^@ http://purl.uniprot.org/uniprot/Q0AUM0 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/335541:SWOL_RS05890 ^@ http://purl.uniprot.org/uniprot/Q0AXU4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/335541:SWOL_RS03565 ^@ http://purl.uniprot.org/uniprot/Q0AZ25 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/335541:SWOL_RS06500 ^@ http://purl.uniprot.org/uniprot/Q0AXI0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsK/SpoIIIE/SftA family.|||Homohexamer. Forms a ring that surrounds DNA.|||Membrane http://togogenome.org/gene/335541:SWOL_RS00040 ^@ http://purl.uniprot.org/uniprot/Q0B0Y9 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/335541:SWOL_RS01600 ^@ http://purl.uniprot.org/uniprot/Q0B048 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.|||Cell membrane http://togogenome.org/gene/335541:SWOL_RS08335 ^@ http://purl.uniprot.org/uniprot/Q0AWJ2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/335541:SWOL_RS09135 ^@ http://purl.uniprot.org/uniprot/Q0AW42 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the PRA-PH family.|||In the N-terminal section; belongs to the PRA-CH family. http://togogenome.org/gene/335541:SWOL_RS01350 ^@ http://purl.uniprot.org/uniprot/Q0B095 ^@ Similarity ^@ Belongs to the PGI/PMI family. http://togogenome.org/gene/335541:SWOL_RS05900 ^@ http://purl.uniprot.org/uniprot/Q0AXU2 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. http://togogenome.org/gene/335541:SWOL_RS06525 ^@ http://purl.uniprot.org/uniprot/Q0AXH6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/335541:SWOL_RS06870 ^@ http://purl.uniprot.org/uniprot/Q0AXB9 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/335541:SWOL_RS13270 ^@ http://purl.uniprot.org/uniprot/Q0ATV0 ^@ Similarity ^@ Belongs to the ParB family. http://togogenome.org/gene/335541:SWOL_RS01455 ^@ http://purl.uniprot.org/uniprot/Q0B075 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/335541:SWOL_RS02965 ^@ http://purl.uniprot.org/uniprot/Q0AZD9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ArgR family.|||Cytoplasm|||Regulates arginine biosynthesis genes. http://togogenome.org/gene/335541:SWOL_RS07640 ^@ http://purl.uniprot.org/uniprot/Q0AWX5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS10430 ^@ http://purl.uniprot.org/uniprot/Q0AVE3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the FPG family.|||Binds 1 zinc ion per subunit.|||Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.|||Monomer. http://togogenome.org/gene/335541:SWOL_RS05565 ^@ http://purl.uniprot.org/uniprot/Q0AY02 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/335541:SWOL_RS13430 ^@ http://purl.uniprot.org/uniprot/Q0B019 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MinC family.|||Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.|||Interacts with MinD and FtsZ. http://togogenome.org/gene/335541:SWOL_RS09265 ^@ http://purl.uniprot.org/uniprot/Q0AW15 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/335541:SWOL_RS08320 ^@ http://purl.uniprot.org/uniprot/Q0AWJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate 5-kinase family.|||Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS02485 ^@ http://purl.uniprot.org/uniprot/Q0AZM9 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/335541:SWOL_RS07395 ^@ http://purl.uniprot.org/uniprot/Q0AX17 ^@ Function|||Similarity ^@ Belongs to the QueH family.|||Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). http://togogenome.org/gene/335541:SWOL_RS11195 ^@ http://purl.uniprot.org/uniprot/Q0AUZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ArsB family.|||Belongs to the CitM (TC 2.A.11) transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS04030 ^@ http://purl.uniprot.org/uniprot/Q0AYT5 ^@ Cofactor ^@ Binds 4 [4Fe-4S] clusters per subunit. http://togogenome.org/gene/335541:SWOL_RS01910 ^@ http://purl.uniprot.org/uniprot/Q0AZZ1 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/335541:SWOL_RS00050 ^@ http://purl.uniprot.org/uniprot/Q0B0Y7 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/335541:SWOL_RS08635 ^@ http://purl.uniprot.org/uniprot/Q0AWD6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DNA polymerase type-Y family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Monomer.|||Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. http://togogenome.org/gene/335541:SWOL_RS00195 ^@ http://purl.uniprot.org/uniprot/Q0B0W3 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/335541:SWOL_RS08255 ^@ http://purl.uniprot.org/uniprot/Q0AWK7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS03440 ^@ http://purl.uniprot.org/uniprot/Q0AZ47 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/335541:SWOL_RS00640 ^@ http://purl.uniprot.org/uniprot/Q0B0N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS02310 ^@ http://purl.uniprot.org/uniprot/Q0AZR5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/335541:SWOL_RS08850 ^@ http://purl.uniprot.org/uniprot/Q0AW93 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/335541:SWOL_RS01435 ^@ http://purl.uniprot.org/uniprot/Q0B079 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/335541:SWOL_RS03915 ^@ http://purl.uniprot.org/uniprot/Q0AYV8 ^@ Caution|||Function|||Similarity ^@ Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.|||Belongs to the biotin--protein ligase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/335541:SWOL_RS08295 ^@ http://purl.uniprot.org/uniprot/Q0AWK0 ^@ Function|||Similarity ^@ Belongs to the NadD family.|||Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). http://togogenome.org/gene/335541:SWOL_RS04210 ^@ http://purl.uniprot.org/uniprot/Q0AYQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase U4 family.|||Cell membrane|||Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. http://togogenome.org/gene/335541:SWOL_RS09920 ^@ http://purl.uniprot.org/uniprot/Q0AVN7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M3B family.|||Binds 1 zinc ion.|||Has oligopeptidase activity and degrades a variety of small bioactive peptides. http://togogenome.org/gene/335541:SWOL_RS08020 ^@ http://purl.uniprot.org/uniprot/Q0AWQ3 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/335541:SWOL_RS08965 ^@ http://purl.uniprot.org/uniprot/Q0AW69 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/335541:SWOL_RS01935 ^@ http://purl.uniprot.org/uniprot/Q0AZY6 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/335541:SWOL_RS12440 ^@ http://purl.uniprot.org/uniprot/Q0AUB5 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/335541:SWOL_RS10970 ^@ http://purl.uniprot.org/uniprot/Q0AV41 ^@ Cofactor|||Similarity ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer. http://togogenome.org/gene/335541:SWOL_RS08790 ^@ http://purl.uniprot.org/uniprot/Q0AWA5 ^@ Similarity ^@ Belongs to the complex I 51 kDa subunit family. http://togogenome.org/gene/335541:SWOL_RS08500 ^@ http://purl.uniprot.org/uniprot/Q0AWG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional regulatory Rex family.|||Cytoplasm|||Homodimer.|||Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. http://togogenome.org/gene/335541:SWOL_RS01695 ^@ http://purl.uniprot.org/uniprot/Q0B029 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/335541:SWOL_RS03230 ^@ http://purl.uniprot.org/uniprot/Q0AZ88 ^@ Similarity ^@ Belongs to the ThiD family. http://togogenome.org/gene/335541:SWOL_RS11090 ^@ http://purl.uniprot.org/uniprot/Q0AV18 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/335541:SWOL_RS12010 ^@ http://purl.uniprot.org/uniprot/Q0AUJ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/335541:SWOL_RS05320 ^@ http://purl.uniprot.org/uniprot/Q0AY43 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.|||Belongs to the organic radical-activating enzymes family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS07745 ^@ http://purl.uniprot.org/uniprot/Q0AWV5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.|||Belongs to the KhpA RNA-binding protein family.|||Cytoplasm|||Forms a complex with KhpB. http://togogenome.org/gene/335541:SWOL_RS01890 ^@ http://purl.uniprot.org/uniprot/Q0AZZ5 ^@ Function|||Similarity ^@ Belongs to the NAD-dependent DNA ligase family. LigA subfamily.|||DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. http://togogenome.org/gene/335541:SWOL_RS04820 ^@ http://purl.uniprot.org/uniprot/Q0AYE0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NrdR family.|||Binds 1 zinc ion.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/335541:SWOL_RS02060 ^@ http://purl.uniprot.org/uniprot/Q0AZW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS12030 ^@ http://purl.uniprot.org/uniprot/Q0AUJ1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/335541:SWOL_RS01075 ^@ http://purl.uniprot.org/uniprot/Q0B0E9 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/335541:SWOL_RS09090 ^@ http://purl.uniprot.org/uniprot/Q0AW50 ^@ Similarity ^@ Belongs to the CRISPR-associated Cas10/Csm1 family. http://togogenome.org/gene/335541:SWOL_RS10555 ^@ http://purl.uniprot.org/uniprot/Q0AVC0 ^@ Similarity ^@ Belongs to the pyruvate kinase family.|||In the C-terminal section; belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/335541:SWOL_RS09930 ^@ http://purl.uniprot.org/uniprot/Q0AVN5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/335541:SWOL_RS12760 ^@ http://purl.uniprot.org/uniprot/Q0AU51 ^@ Similarity ^@ Belongs to the UPF0145 family. http://togogenome.org/gene/335541:SWOL_RS13440 ^@ http://purl.uniprot.org/uniprot/Q0AZZ9 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/335541:SWOL_RS09730 ^@ http://purl.uniprot.org/uniprot/Q0AVS4 ^@ Function|||Similarity ^@ Belongs to the alanine racemase family.|||Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. http://togogenome.org/gene/335541:SWOL_RS09325 ^@ http://purl.uniprot.org/uniprot/Q0AW03 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/335541:SWOL_RS06860 ^@ http://purl.uniprot.org/uniprot/Q0AXC1 ^@ Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||GTPase that plays an essential role in the late steps of ribosome biogenesis. http://togogenome.org/gene/335541:SWOL_RS03905 ^@ http://purl.uniprot.org/uniprot/Q0AYW0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribonuclease III family.|||Cytoplasm|||Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS03105 ^@ http://purl.uniprot.org/uniprot/Q0AZB2 ^@ Function|||Similarity ^@ Belongs to the anti-sigma-factor antagonist family.|||In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma f from inhibition. http://togogenome.org/gene/335541:SWOL_RS06080 ^@ http://purl.uniprot.org/uniprot/Q0AXR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS08510 ^@ http://purl.uniprot.org/uniprot/Q0AWF8 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/335541:SWOL_RS02435 ^@ http://purl.uniprot.org/uniprot/Q0AZN9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/335541:SWOL_RS03975 ^@ http://purl.uniprot.org/uniprot/Q0AYU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyl-CoA hydrolase/transferase family.|||Coenzyme A-transferase that converts butyrate to butyryl-CoA.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS08855 ^@ http://purl.uniprot.org/uniprot/Q0AW92 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS08555 ^@ http://purl.uniprot.org/uniprot/Q0AWF0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/335541:SWOL_RS04235 ^@ http://purl.uniprot.org/uniprot/Q0AYP6 ^@ Similarity ^@ Belongs to the DprA/Smf family. http://togogenome.org/gene/335541:SWOL_RS03895 ^@ http://purl.uniprot.org/uniprot/Q0AYW2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsX family.|||Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.|||Cytoplasm|||Homodimer. Probably interacts with PlsY. http://togogenome.org/gene/335541:SWOL_RS01640 ^@ http://purl.uniprot.org/uniprot/Q0B041 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0702 family.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS12775 ^@ http://purl.uniprot.org/uniprot/Q0AU48 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase RlmH family.|||Cytoplasm|||Homodimer.|||Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. http://togogenome.org/gene/335541:SWOL_RS12600 ^@ http://purl.uniprot.org/uniprot/Q0AU83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nlpA lipoprotein family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS09155 ^@ http://purl.uniprot.org/uniprot/Q0AW38 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. http://togogenome.org/gene/335541:SWOL_RS02370 ^@ http://purl.uniprot.org/uniprot/Q0AZQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS08445 ^@ http://purl.uniprot.org/uniprot/Q0AWH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEDS family. MrdB/RodA subfamily.|||Cell membrane|||Membrane|||Peptidoglycan polymerase that is essential for cell wall elongation. http://togogenome.org/gene/335541:SWOL_RS08250 ^@ http://purl.uniprot.org/uniprot/Q0AWK8 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/335541:SWOL_RS03235 ^@ http://purl.uniprot.org/uniprot/Q0AZ87 ^@ Function|||Similarity ^@ Belongs to the Thz kinase family.|||Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ). http://togogenome.org/gene/335541:SWOL_RS11985 ^@ http://purl.uniprot.org/uniprot/Q0AUK0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/335541:SWOL_RS08345 ^@ http://purl.uniprot.org/uniprot/Q0AWJ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/335541:SWOL_RS09290 ^@ http://purl.uniprot.org/uniprot/Q0AW11 ^@ Similarity ^@ Belongs to the anti-sigma-factor antagonist family. http://togogenome.org/gene/335541:SWOL_RS03170 ^@ http://purl.uniprot.org/uniprot/Q0AZ99 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/335541:SWOL_RS08550 ^@ http://purl.uniprot.org/uniprot/Q0AWF1 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/335541:SWOL_RS06710 ^@ http://purl.uniprot.org/uniprot/Q0AXE5 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/335541:SWOL_RS06815 ^@ http://purl.uniprot.org/uniprot/Q0AXC9 ^@ Function|||Similarity ^@ Belongs to the aspartokinase family.|||Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine. http://togogenome.org/gene/335541:SWOL_RS04180 ^@ http://purl.uniprot.org/uniprot/Q0AYQ6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/335541:SWOL_RS09715 ^@ http://purl.uniprot.org/uniprot/Q0AVS7 ^@ Function|||Similarity ^@ Belongs to the PemK/MazF family.|||Toxic component of a type II toxin-antitoxin (TA) system. http://togogenome.org/gene/335541:SWOL_RS13350 ^@ http://purl.uniprot.org/uniprot/Q0B0M4 ^@ Similarity ^@ Belongs to the LytR/CpsA/Psr (LCP) family. http://togogenome.org/gene/335541:SWOL_RS02710 ^@ http://purl.uniprot.org/uniprot/Q0AZI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS06485 ^@ http://purl.uniprot.org/uniprot/Q0AXI3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methylthiotransferase family. RimO subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS13495 ^@ http://purl.uniprot.org/uniprot/Q0AYP7 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/335541:SWOL_RS06570 ^@ http://purl.uniprot.org/uniprot/Q0AXG7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the OMP decarboxylase family. Type 1 subfamily.|||Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS06505 ^@ http://purl.uniprot.org/uniprot/Q0AXH9 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell membrane http://togogenome.org/gene/335541:SWOL_RS00960 ^@ http://purl.uniprot.org/uniprot/Q0B0H1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS07720 ^@ http://purl.uniprot.org/uniprot/Q0AWW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.|||Cytoplasm|||Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity. http://togogenome.org/gene/335541:SWOL_RS06825 ^@ http://purl.uniprot.org/uniprot/Q0AXC7 ^@ Similarity ^@ Belongs to the homoserine dehydrogenase family. http://togogenome.org/gene/335541:SWOL_RS06875 ^@ http://purl.uniprot.org/uniprot/Q0AXB8 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/335541:SWOL_RS09785 ^@ http://purl.uniprot.org/uniprot/Q0AVR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP38/TMEM64 family.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS04390 ^@ http://purl.uniprot.org/uniprot/Q0AYL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family.|||Cell membrane|||Membrane|||Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum. http://togogenome.org/gene/335541:SWOL_RS08960 ^@ http://purl.uniprot.org/uniprot/Q0AW70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS03325 ^@ http://purl.uniprot.org/uniprot/Q0AZ70 ^@ Similarity ^@ Belongs to the complex I 51 kDa subunit family. http://togogenome.org/gene/335541:SWOL_RS07750 ^@ http://purl.uniprot.org/uniprot/Q0AWV4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/335541:SWOL_RS01410 ^@ http://purl.uniprot.org/uniprot/Q0B084 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/335541:SWOL_RS00160 ^@ http://purl.uniprot.org/uniprot/Q0B0X0 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/335541:SWOL_RS08515 ^@ http://purl.uniprot.org/uniprot/Q0AWF7 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/335541:SWOL_RS02885 ^@ http://purl.uniprot.org/uniprot/Q0AZF2 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/335541:SWOL_RS04375 ^@ http://purl.uniprot.org/uniprot/Q0AYL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliR/MopE/SpaR family.|||Cell membrane|||Membrane|||Role in flagellar biosynthesis. http://togogenome.org/gene/335541:SWOL_RS02630 ^@ http://purl.uniprot.org/uniprot/Q0AZK1 ^@ Function ^@ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. http://togogenome.org/gene/335541:SWOL_RS09145 ^@ http://purl.uniprot.org/uniprot/Q0AW40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS08450 ^@ http://purl.uniprot.org/uniprot/Q0AWH0 ^@ Function|||Similarity ^@ Belongs to the MinE family.|||Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. http://togogenome.org/gene/335541:SWOL_RS11390 ^@ http://purl.uniprot.org/uniprot/Q0AUU4 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/335541:SWOL_RS07880 ^@ http://purl.uniprot.org/uniprot/Q0AWT0 ^@ Similarity ^@ Belongs to the cytochrome c-552 family. http://togogenome.org/gene/335541:SWOL_RS08690 ^@ http://purl.uniprot.org/uniprot/Q0AWC5 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/335541:SWOL_RS11995 ^@ http://purl.uniprot.org/uniprot/Q0AUJ8 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/335541:SWOL_RS10415 ^@ http://purl.uniprot.org/uniprot/Q0AVE6 ^@ Similarity ^@ Belongs to the transglycosylase Slt family. http://togogenome.org/gene/335541:SWOL_RS12310 ^@ http://purl.uniprot.org/uniprot/Q0AUE1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/335541:SWOL_RS05205 ^@ http://purl.uniprot.org/uniprot/Q0AY65 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/335541:SWOL_RS10215 ^@ http://purl.uniprot.org/uniprot/Q0AVI1 ^@ Similarity ^@ Belongs to the bacterial reverse transcriptase family. http://togogenome.org/gene/335541:SWOL_RS10305 ^@ http://purl.uniprot.org/uniprot/Q0AVG4 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/335541:SWOL_RS12355 ^@ http://purl.uniprot.org/uniprot/Q0AUD2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase gamma chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. http://togogenome.org/gene/335541:SWOL_RS04685 ^@ http://purl.uniprot.org/uniprot/Q0AYF8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Monomer. http://togogenome.org/gene/335541:SWOL_RS04370 ^@ http://purl.uniprot.org/uniprot/Q0AYM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliQ/MopD/SpaQ family.|||Cell membrane|||Membrane|||Role in flagellar biosynthesis. http://togogenome.org/gene/335541:SWOL_RS11470 ^@ http://purl.uniprot.org/uniprot/Q0AUU4 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/335541:SWOL_RS12525 ^@ http://purl.uniprot.org/uniprot/Q0AU97 ^@ Activity Regulation|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer. http://togogenome.org/gene/335541:SWOL_RS00705 ^@ http://purl.uniprot.org/uniprot/Q0B0L9 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/335541:SWOL_RS04540 ^@ http://purl.uniprot.org/uniprot/Q0AYI7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/335541:SWOL_RS02380 ^@ http://purl.uniprot.org/uniprot/Q0AZQ0 ^@ Similarity ^@ Belongs to the UPF0297 family. http://togogenome.org/gene/335541:SWOL_RS08275 ^@ http://purl.uniprot.org/uniprot/Q0AWK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS13120 ^@ http://purl.uniprot.org/uniprot/Q0ATX7 ^@ Caution|||Function|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. http://togogenome.org/gene/335541:SWOL_RS06715 ^@ http://purl.uniprot.org/uniprot/Q0AXE4 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/335541:SWOL_RS10065 ^@ http://purl.uniprot.org/uniprot/Q0AVK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS01840 ^@ http://purl.uniprot.org/uniprot/Q0B005 ^@ Similarity ^@ Belongs to the TrpC family. http://togogenome.org/gene/335541:SWOL_RS11965 ^@ http://purl.uniprot.org/uniprot/Q0AUK4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/335541:SWOL_RS09700 ^@ http://purl.uniprot.org/uniprot/Q0AVT0 ^@ Function|||Similarity ^@ Belongs to the PemK/MazF family.|||Toxic component of a type II toxin-antitoxin (TA) system. http://togogenome.org/gene/335541:SWOL_RS09195 ^@ http://purl.uniprot.org/uniprot/Q0AW30 ^@ Function|||Similarity ^@ Belongs to the GART family.|||Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. http://togogenome.org/gene/335541:SWOL_RS04580 ^@ http://purl.uniprot.org/uniprot/Q0AYH9 ^@ Function|||Similarity ^@ Belongs to the peptidase S11 family.|||Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. http://togogenome.org/gene/335541:SWOL_RS03305 ^@ http://purl.uniprot.org/uniprot/Q0AZ74 ^@ Similarity ^@ Belongs to the PHP hydrolase family. HisK subfamily. http://togogenome.org/gene/335541:SWOL_RS04425 ^@ http://purl.uniprot.org/uniprot/Q0AYK9 ^@ Function|||Similarity ^@ Belongs to the CheD family.|||Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis. http://togogenome.org/gene/335541:SWOL_RS09625 ^@ http://purl.uniprot.org/uniprot/Q0AVU3 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/335541:SWOL_RS12075 ^@ http://purl.uniprot.org/uniprot/Q0AUI2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/335541:SWOL_RS12380 ^@ http://purl.uniprot.org/uniprot/Q0AUC7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase A chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.|||Membrane http://togogenome.org/gene/335541:SWOL_RS04045 ^@ http://purl.uniprot.org/uniprot/Q0AYT2 ^@ Function|||Similarity ^@ Belongs to the MoeA family.|||Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.|||May be involved in the biosynthesis of molybdopterin. http://togogenome.org/gene/335541:SWOL_RS13685 ^@ http://purl.uniprot.org/uniprot/Q0AVN8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 130 family. http://togogenome.org/gene/335541:SWOL_RS00690 ^@ http://purl.uniprot.org/uniprot/Q0B0M2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS12735 ^@ http://purl.uniprot.org/uniprot/Q0AU56 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/335541:SWOL_RS07815 ^@ http://purl.uniprot.org/uniprot/Q0AWU4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoD/SigA subfamily.|||Cytoplasm|||Interacts transiently with the RNA polymerase catalytic core.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. http://togogenome.org/gene/335541:SWOL_RS03415 ^@ http://purl.uniprot.org/uniprot/Q0AZ52 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/335541:SWOL_RS00150 ^@ http://purl.uniprot.org/uniprot/Q0AUU4 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/335541:SWOL_RS07840 ^@ http://purl.uniprot.org/uniprot/Q0AWT9 ^@ Similarity ^@ Belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/335541:SWOL_RS03085 ^@ http://purl.uniprot.org/uniprot/Q0AZB6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.|||Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS02870 ^@ http://purl.uniprot.org/uniprot/Q0AZF5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS02080 ^@ http://purl.uniprot.org/uniprot/Q0AZV8 ^@ Similarity ^@ Belongs to the NifH/BchL/ChlL family. http://togogenome.org/gene/335541:SWOL_RS12240 ^@ http://purl.uniprot.org/uniprot/Q0AUF5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IspF family.|||Binds 1 divalent metal cation per subunit.|||Homotrimer.|||Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). http://togogenome.org/gene/335541:SWOL_RS03665 ^@ http://purl.uniprot.org/uniprot/Q0AZ05 ^@ Similarity ^@ Belongs to the polysaccharide synthase family. http://togogenome.org/gene/335541:SWOL_RS08165 ^@ http://purl.uniprot.org/uniprot/Q0AWM4 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/335541:SWOL_RS10005 ^@ http://purl.uniprot.org/uniprot/Q0AVM1 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||Cytoplasm|||Highly expressed during syntrophic growth with butyrate (at protein level). Seems to be constitutively expressed.|||Homotetramer.|||Involved in syntrophic growth of S.wolfei with butyrate, as part of the butyrate oxidation pathway. Probably catalyzes the hydration of crotonyl-CoA to 3-hydroxybutyryl-CoA. http://togogenome.org/gene/335541:SWOL_RS00425 ^@ http://purl.uniprot.org/uniprot/Q0B0S6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/335541:SWOL_RS08185 ^@ http://purl.uniprot.org/uniprot/Q0AWM1 ^@ Function|||Similarity ^@ Belongs to the HrcA family.|||Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons. http://togogenome.org/gene/335541:SWOL_RS10975 ^@ http://purl.uniprot.org/uniprot/Q0AV40 ^@ Similarity ^@ Belongs to the ETF beta-subunit/FixA family. http://togogenome.org/gene/335541:SWOL_RS11150 ^@ http://purl.uniprot.org/uniprot/Q0AV06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GtrA family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS06580 ^@ http://purl.uniprot.org/uniprot/Q0AXG5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrK family.|||Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit.|||Heterotetramer of 2 PyrK and 2 PyrD type B subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). http://togogenome.org/gene/335541:SWOL_RS04555 ^@ http://purl.uniprot.org/uniprot/Q0AYI4 ^@ Similarity ^@ Belongs to the ribF family. http://togogenome.org/gene/335541:SWOL_RS09570 ^@ http://purl.uniprot.org/uniprot/Q0AVV5 ^@ Similarity ^@ Belongs to the fabD family. http://togogenome.org/gene/335541:SWOL_RS03875 ^@ http://purl.uniprot.org/uniprot/Q0AYW6 ^@ Similarity ^@ Belongs to the phosphate acetyltransferase and butyryltransferase family. http://togogenome.org/gene/335541:SWOL_RS09130 ^@ http://purl.uniprot.org/uniprot/Q0AW43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0053 family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS04850 ^@ http://purl.uniprot.org/uniprot/Q0AYD4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS00475 ^@ http://purl.uniprot.org/uniprot/Q0B0R6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS01995 ^@ http://purl.uniprot.org/uniprot/Q0AZX4 ^@ Similarity ^@ Belongs to the YoeB family. http://togogenome.org/gene/335541:SWOL_RS03520 ^@ http://purl.uniprot.org/uniprot/Q0AZ33 ^@ Cofactor|||Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per subunit.|||Cytoplasm|||Heterodimer of an alpha and a beta subunit.|||Highly expressed during syntrophic growth with butyrate (at protein level) (PubMed:19648244, PubMed:23468890). Seems to be constitutively expressed (PubMed:23468890).|||Part of an electron transfer flavoprotein involved in syntrophic growth of S.wolfei with butyrate. Probably receives electrons from butyryl-CoA dehydrogenases, and transfers them to the membrane-bound quinone oxidoreductase Swol_0698. http://togogenome.org/gene/335541:SWOL_RS04095 ^@ http://purl.uniprot.org/uniprot/Q0AYS2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS10420 ^@ http://purl.uniprot.org/uniprot/Q0AVE5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CoaE family.|||Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS06615 ^@ http://purl.uniprot.org/uniprot/Q0AXF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A8 family.|||Cell membrane|||This protein specifically catalyzes the removal of signal peptides from prolipoproteins. http://togogenome.org/gene/335541:SWOL_RS00025 ^@ http://purl.uniprot.org/uniprot/Q0B0Z2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecF family.|||Cytoplasm|||The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. http://togogenome.org/gene/335541:SWOL_RS12020 ^@ http://purl.uniprot.org/uniprot/Q0AUJ3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/335541:SWOL_RS04845 ^@ http://purl.uniprot.org/uniprot/Q0AYD5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SepF family.|||Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.|||Cytoplasm|||Homodimer. Interacts with FtsZ. http://togogenome.org/gene/335541:SWOL_RS02505 ^@ http://purl.uniprot.org/uniprot/Q0AZM5 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/335541:SWOL_RS05215 ^@ http://purl.uniprot.org/uniprot/Q0AY63 ^@ Function|||Similarity ^@ Belongs to the MoeA family.|||Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. http://togogenome.org/gene/335541:SWOL_RS03935 ^@ http://purl.uniprot.org/uniprot/Q0AYV4 ^@ Function|||Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). http://togogenome.org/gene/335541:SWOL_RS06365 ^@ http://purl.uniprot.org/uniprot/Q0AXK6 ^@ Similarity ^@ Belongs to the YicC/YloC family. http://togogenome.org/gene/335541:SWOL_RS02960 ^@ http://purl.uniprot.org/uniprot/Q0AZE0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. http://togogenome.org/gene/335541:SWOL_RS08520 ^@ http://purl.uniprot.org/uniprot/Q0AWF6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Monomer.|||The C-terminal coiled-coil domain is crucial for aminoacylation activity.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/335541:SWOL_RS05585 ^@ http://purl.uniprot.org/uniprot/Q0AXZ8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 26 family. http://togogenome.org/gene/335541:SWOL_RS13010 ^@ http://purl.uniprot.org/uniprot/Q0ATZ8 ^@ Similarity ^@ In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.|||In the central section; belongs to the CRISPR-associated helicase Cas3 family. http://togogenome.org/gene/335541:SWOL_RS12365 ^@ http://purl.uniprot.org/uniprot/Q0AUD0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase delta chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction. http://togogenome.org/gene/335541:SWOL_RS02045 ^@ http://purl.uniprot.org/uniprot/Q0AZW4 ^@ Cofactor ^@ Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/335541:SWOL_RS04490 ^@ http://purl.uniprot.org/uniprot/Q0AYJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS03505 ^@ http://purl.uniprot.org/uniprot/Q0AZ36 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS03840 ^@ http://purl.uniprot.org/uniprot/Q0AYX1 ^@ Function|||PTM|||Similarity|||Subunit ^@ Autoproteolytically processed. The inactive tetrameric zymogen termed p46 autoprocesses to a smaller form termed p41, which is active only during spore germination.|||Belongs to the peptidase A25 family.|||Homotetramer.|||Initiates the rapid degradation of small, acid-soluble proteins during spore germination. http://togogenome.org/gene/335541:SWOL_RS00105 ^@ http://purl.uniprot.org/uniprot/Q0B0Y0 ^@ Similarity ^@ Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family. http://togogenome.org/gene/335541:SWOL_RS01725 ^@ http://purl.uniprot.org/uniprot/Q0B023 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS08795 ^@ http://purl.uniprot.org/uniprot/Q0AWA4 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/335541:SWOL_RS03060 ^@ http://purl.uniprot.org/uniprot/Q0AZC1 ^@ Similarity ^@ Belongs to the HepT RNase toxin family. http://togogenome.org/gene/335541:SWOL_RS13300 ^@ http://purl.uniprot.org/uniprot/Q0ATU4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable RNA chaperone. Forms a complex with KhpA which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.|||Belongs to the KhpB RNA-binding protein family.|||Cytoplasm|||Forms a complex with KhpA.|||Has an N-terminal Jag-N domain and 2 RNA-binding domains (KH and R3H). http://togogenome.org/gene/335541:SWOL_RS03890 ^@ http://purl.uniprot.org/uniprot/Q0AYW3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/335541:SWOL_RS12135 ^@ http://purl.uniprot.org/uniprot/Q0AUH0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/335541:SWOL_RS09630 ^@ http://purl.uniprot.org/uniprot/Q0AVU2 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/335541:SWOL_RS04865 ^@ http://purl.uniprot.org/uniprot/Q0AYD1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/335541:SWOL_RS07740 ^@ http://purl.uniprot.org/uniprot/Q0AWV6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.|||Belongs to the RimM family.|||Binds ribosomal protein uS19.|||Cytoplasm|||The PRC barrel domain binds ribosomal protein uS19. http://togogenome.org/gene/335541:SWOL_RS09805 ^@ http://purl.uniprot.org/uniprot/Q0AVQ9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/335541:SWOL_RS06360 ^@ http://purl.uniprot.org/uniprot/Q0AXK7 ^@ Similarity ^@ Belongs to the RemA family. http://togogenome.org/gene/335541:SWOL_RS04935 ^@ http://purl.uniprot.org/uniprot/Q0AYB8 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/335541:SWOL_RS08315 ^@ http://purl.uniprot.org/uniprot/Q0AWJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyl phosphate reductase family.|||Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS10810 ^@ http://purl.uniprot.org/uniprot/Q0AV73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TsuA/YedE (TC 9.B.102) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS06585 ^@ http://purl.uniprot.org/uniprot/Q0AXG4 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/335541:SWOL_RS04505 ^@ http://purl.uniprot.org/uniprot/Q0AYJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MgtC/SapB family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS04750 ^@ http://purl.uniprot.org/uniprot/Q0AYF4 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/335541:SWOL_RS05200 ^@ http://purl.uniprot.org/uniprot/Q0AY66 ^@ Similarity ^@ Belongs to the complex I 51 kDa subunit family. http://togogenome.org/gene/335541:SWOL_RS03250 ^@ http://purl.uniprot.org/uniprot/Q0AZ84 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ThiC family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. http://togogenome.org/gene/335541:SWOL_RS04255 ^@ http://purl.uniprot.org/uniprot/Q0AYP2 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||Allosterically activated by HslU binding.|||Belongs to the peptidase T1B family. HslV subfamily.|||Cytoplasm|||Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. http://togogenome.org/gene/335541:SWOL_RS03925 ^@ http://purl.uniprot.org/uniprot/Q0AYV6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Membrane|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/335541:SWOL_RS12005 ^@ http://purl.uniprot.org/uniprot/Q0AUJ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/335541:SWOL_RS04050 ^@ http://purl.uniprot.org/uniprot/Q0AYT1 ^@ Function|||Similarity ^@ Belongs to the MoeA family.|||Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. http://togogenome.org/gene/335541:SWOL_RS13090 ^@ http://purl.uniprot.org/uniprot/Q0ATY3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/335541:SWOL_RS04270 ^@ http://purl.uniprot.org/uniprot/Q0AYN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family.|||Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.|||The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod. http://togogenome.org/gene/335541:SWOL_RS10435 ^@ http://purl.uniprot.org/uniprot/Q0AVE2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA polymerase type-A family.|||In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.|||Single-chain monomer with multiple functions. http://togogenome.org/gene/335541:SWOL_RS03930 ^@ http://purl.uniprot.org/uniprot/Q0AYV5 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.|||Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Homohexamer. Dimer of a homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. http://togogenome.org/gene/335541:SWOL_RS02955 ^@ http://purl.uniprot.org/uniprot/Q0AZE1 ^@ Similarity ^@ Belongs to the TlyA family. http://togogenome.org/gene/335541:SWOL_RS05285 ^@ http://purl.uniprot.org/uniprot/Q0AY50 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/335541:SWOL_RS03275 ^@ http://purl.uniprot.org/uniprot/Q0AZ79 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/335541:SWOL_RS05555 ^@ http://purl.uniprot.org/uniprot/Q0AY04 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-3 family.|||Cytoplasm|||IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.|||Monomer. http://togogenome.org/gene/335541:SWOL_RS04560 ^@ http://purl.uniprot.org/uniprot/Q0AYI3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/335541:SWOL_RS12410 ^@ http://purl.uniprot.org/uniprot/Q0AUC1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MntP (TC 9.B.29) family.|||Cell membrane|||Probably functions as a manganese efflux pump. http://togogenome.org/gene/335541:SWOL_RS11910 ^@ http://purl.uniprot.org/uniprot/Q0AUL5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/335541:SWOL_RS06110 ^@ http://purl.uniprot.org/uniprot/Q0AXQ4 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/335541:SWOL_RS13750 ^@ http://purl.uniprot.org/uniprot/Q0AV56 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/335541:SWOL_RS07385 ^@ http://purl.uniprot.org/uniprot/Q0AX19 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).|||Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1. http://togogenome.org/gene/335541:SWOL_RS00445 ^@ http://purl.uniprot.org/uniprot/Q0B0S2 ^@ Similarity ^@ Belongs to the GerABKC lipoprotein family. http://togogenome.org/gene/335541:SWOL_RS12505 ^@ http://purl.uniprot.org/uniprot/Q0AUA2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS02150 ^@ http://purl.uniprot.org/uniprot/Q0AZU5 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily. http://togogenome.org/gene/335541:SWOL_RS04885 ^@ http://purl.uniprot.org/uniprot/Q0AYC7 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/335541:SWOL_RS08800 ^@ http://purl.uniprot.org/uniprot/Q0AWA3 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/335541:SWOL_RS02755 ^@ http://purl.uniprot.org/uniprot/Q0AZH8 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/335541:SWOL_RS01430 ^@ http://purl.uniprot.org/uniprot/Q0B080 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/335541:SWOL_RS10240 ^@ http://purl.uniprot.org/uniprot/Q0AVH7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/335541:SWOL_RS04775 ^@ http://purl.uniprot.org/uniprot/Q0AYE9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the diaminopimelate dehydrogenase family.|||Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate.|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS08540 ^@ http://purl.uniprot.org/uniprot/Q0AWF3 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.|||Belongs to the peptidase S16 family.|||By heat shock.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity. http://togogenome.org/gene/335541:SWOL_RS06325 ^@ http://purl.uniprot.org/uniprot/Q0AXL4 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/335541:SWOL_RS00810 ^@ http://purl.uniprot.org/uniprot/Q0B0K0 ^@ Similarity ^@ Belongs to the RelB/DinJ antitoxin family. http://togogenome.org/gene/335541:SWOL_RS05155 ^@ http://purl.uniprot.org/uniprot/Q0AY75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurB family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/335541:SWOL_RS01045 ^@ http://purl.uniprot.org/uniprot/Q0B0F5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum|||Belongs to the FliD family.|||Homopentamer.|||Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.|||Secreted http://togogenome.org/gene/335541:SWOL_RS07700 ^@ http://purl.uniprot.org/uniprot/Q0AWW4 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/335541:SWOL_RS00605 ^@ http://purl.uniprot.org/uniprot/Q0B0N9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A monovalent cation. Ammonium or potassium.|||Belongs to the type III pantothenate kinase family.|||Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS11680 ^@ http://purl.uniprot.org/uniprot/Q0AUQ6 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/335541:SWOL_RS07435 ^@ http://purl.uniprot.org/uniprot/Q0AX09 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/335541:SWOL_RS06165 ^@ http://purl.uniprot.org/uniprot/Q0AXP4 ^@ Similarity ^@ Belongs to the helicase family. DnaB subfamily. http://togogenome.org/gene/335541:SWOL_RS11075 ^@ http://purl.uniprot.org/uniprot/Q0AV21 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/335541:SWOL_RS09075 ^@ http://purl.uniprot.org/uniprot/Q0AW53 ^@ Similarity ^@ Belongs to the CRISPR-associated Csm4 family. http://togogenome.org/gene/335541:SWOL_RS06970 ^@ http://purl.uniprot.org/uniprot/Q0AX99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Monomer. http://togogenome.org/gene/335541:SWOL_RS03960 ^@ http://purl.uniprot.org/uniprot/Q0AYU9 ^@ Similarity ^@ Belongs to the complex I 51 kDa subunit family. http://togogenome.org/gene/335541:SWOL_RS05300 ^@ http://purl.uniprot.org/uniprot/Q0AY47 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS12350 ^@ http://purl.uniprot.org/uniprot/Q0AUD3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. http://togogenome.org/gene/335541:SWOL_RS08545 ^@ http://purl.uniprot.org/uniprot/Q0AWF2 ^@ Similarity ^@ Belongs to the peptidase S16 family. http://togogenome.org/gene/335541:SWOL_RS04790 ^@ http://purl.uniprot.org/uniprot/Q0AYE6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/335541:SWOL_RS07045 ^@ http://purl.uniprot.org/uniprot/Q0AX85 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DNA polymerase type-Y family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Monomer.|||Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. http://togogenome.org/gene/335541:SWOL_RS01845 ^@ http://purl.uniprot.org/uniprot/Q0B004 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/335541:SWOL_RS03595 ^@ http://purl.uniprot.org/uniprot/Q0AZ19 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/335541:SWOL_RS09230 ^@ http://purl.uniprot.org/uniprot/Q0AW22 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS12490 ^@ http://purl.uniprot.org/uniprot/Q0AUA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transaldolase family. Type 3B subfamily.|||Cytoplasm|||Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. http://togogenome.org/gene/335541:SWOL_RS05260 ^@ http://purl.uniprot.org/uniprot/Q0AVI1 ^@ Similarity ^@ Belongs to the bacterial reverse transcriptase family. http://togogenome.org/gene/335541:SWOL_RS00155 ^@ http://purl.uniprot.org/uniprot/Q0AUU5 ^@ Similarity ^@ Belongs to the transposase IS21/IS408/IS1162 family. http://togogenome.org/gene/335541:SWOL_RS10570 ^@ http://purl.uniprot.org/uniprot/Q0AVB7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DNA polymerase type-C family. DnaE subfamily.|||Cytoplasm|||DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase. http://togogenome.org/gene/335541:SWOL_RS03015 ^@ http://purl.uniprot.org/uniprot/Q0AZD0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/335541:SWOL_RS01245 ^@ http://purl.uniprot.org/uniprot/Q0B0B5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.|||Cytoplasm|||Interacts with 100S ribosomes.|||Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. http://togogenome.org/gene/335541:SWOL_RS03410 ^@ http://purl.uniprot.org/uniprot/Q0AZ53 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.|||Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain. http://togogenome.org/gene/335541:SWOL_RS03110 ^@ http://purl.uniprot.org/uniprot/Q0AZB1 ^@ Function|||Similarity ^@ Belongs to the anti-sigma-factor family.|||Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. http://togogenome.org/gene/335541:SWOL_RS11950 ^@ http://purl.uniprot.org/uniprot/Q0AUK7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/335541:SWOL_RS04405 ^@ http://purl.uniprot.org/uniprot/Q0AYL3 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CheB family.|||Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.|||Cytoplasm|||Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.|||Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity. http://togogenome.org/gene/335541:SWOL_RS03150 ^@ http://purl.uniprot.org/uniprot/Q0AZA3 ^@ Similarity ^@ Belongs to the glycosyltransferase 10 family. http://togogenome.org/gene/335541:SWOL_RS11225 ^@ http://purl.uniprot.org/uniprot/Q0AUZ1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS12785 ^@ http://purl.uniprot.org/uniprot/Q0AU46 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/335541:SWOL_RS07755 ^@ http://purl.uniprot.org/uniprot/Q0AWV3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/335541:SWOL_RS01010 ^@ http://purl.uniprot.org/uniprot/Q0B0G2 ^@ Similarity ^@ Belongs to the FlgM family. http://togogenome.org/gene/335541:SWOL_RS06465 ^@ http://purl.uniprot.org/uniprot/Q0AXI7 ^@ Similarity ^@ Belongs to the AAA ATPase family.|||In the C-terminal section; belongs to the peptidase M41 family. http://togogenome.org/gene/335541:SWOL_RS07220 ^@ http://purl.uniprot.org/uniprot/Q0AX53 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/335541:SWOL_RS06305 ^@ http://purl.uniprot.org/uniprot/Q0AXL8 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RlmN family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm|||Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.|||Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. http://togogenome.org/gene/335541:SWOL_RS11175 ^@ http://purl.uniprot.org/uniprot/Q0AV01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family.|||Membrane http://togogenome.org/gene/335541:SWOL_RS12480 ^@ http://purl.uniprot.org/uniprot/Q0AUA7 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the Rho family.|||Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.|||Homohexamer. The homohexamer assembles into an open ring structure.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/335541:SWOL_RS00045 ^@ http://purl.uniprot.org/uniprot/Q0B0Y8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/335541:SWOL_RS04340 ^@ http://purl.uniprot.org/uniprot/Q0AYM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FliL family.|||Cell membrane|||Controls the rotational direction of flagella during chemotaxis.|||Membrane http://togogenome.org/gene/335541:SWOL_RS02215 ^@ http://purl.uniprot.org/uniprot/Q0AZT4 ^@ Similarity ^@ Belongs to the YoeB family. http://togogenome.org/gene/335541:SWOL_RS03465 ^@ http://purl.uniprot.org/uniprot/Q0AZ43 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Monomer.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethane group. http://togogenome.org/gene/335541:SWOL_RS04240 ^@ http://purl.uniprot.org/uniprot/Q0AYP5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/335541:SWOL_RS04075 ^@ http://purl.uniprot.org/uniprot/Q0AYS6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.|||An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.|||Belongs to the DTD family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS12585 ^@ http://purl.uniprot.org/uniprot/Q0AU86 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/335541:SWOL_RS02950 ^@ http://purl.uniprot.org/uniprot/Q0AZE2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family. DXPS subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS05635 ^@ http://purl.uniprot.org/uniprot/Q0AXY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0702 family.|||Cell membrane|||Membrane http://togogenome.org/gene/335541:SWOL_RS03475 ^@ http://purl.uniprot.org/uniprot/Q0AZ42 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/335541:SWOL_RS07080 ^@ http://purl.uniprot.org/uniprot/Q0AX78 ^@ Similarity ^@ Belongs to the GbsR family. http://togogenome.org/gene/335541:SWOL_RS00630 ^@ http://purl.uniprot.org/uniprot/Q0B0N4 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/335541:SWOL_RS05930 ^@ http://purl.uniprot.org/uniprot/Q0AXT7 ^@ Function|||Similarity ^@ Belongs to the MqnA/MqnD family. MqnA subfamily.|||Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). http://togogenome.org/gene/335541:SWOL_RS04810 ^@ http://purl.uniprot.org/uniprot/Q0AYE2 ^@ Similarity ^@ Belongs to the flagella basal body rod proteins family. http://togogenome.org/gene/335541:SWOL_RS09425 ^@ http://purl.uniprot.org/uniprot/Q0AVY2 ^@ Cofactor ^@ Binds 4 [4Fe-4S] clusters per subunit. http://togogenome.org/gene/335541:SWOL_RS06150 ^@ http://purl.uniprot.org/uniprot/Q0AXP7 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/335541:SWOL_RS07285 ^@ http://purl.uniprot.org/uniprot/Q0AX39 ^@ Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase I family.|||Homopolymer. http://togogenome.org/gene/335541:SWOL_RS02295 ^@ http://purl.uniprot.org/uniprot/Q0AZR8 ^@ Similarity ^@ Belongs to the FldB/FldC dehydratase alpha/beta subunit family. http://togogenome.org/gene/335541:SWOL_RS00575 ^@ http://purl.uniprot.org/uniprot/Q0B0P5 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pantothenate synthetase family.|||Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.|||Cytoplasm|||Homodimer.|||The reaction proceeds by a bi uni uni bi ping pong mechanism.