http://togogenome.org/gene/351160:RCI_RS14550 ^@ http://purl.uniprot.org/uniprot/Q0W8K9 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/351160:RCI_RS08130 ^@ http://purl.uniprot.org/uniprot/Q0W4U0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS13985 ^@ http://purl.uniprot.org/uniprot/Q0W8A2 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/351160:RCI_RS11515 ^@ http://purl.uniprot.org/uniprot/Q0W6V8 ^@ Similarity ^@ Belongs to the tRNA(His) guanylyltransferase family. http://togogenome.org/gene/351160:RCI_RS14045 ^@ http://purl.uniprot.org/uniprot/Q0W8B4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/351160:RCI_RS10660 ^@ http://purl.uniprot.org/uniprot/Q0W6C9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS05405 ^@ http://purl.uniprot.org/uniprot/Q0W358 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/351160:RCI_RS15560 ^@ http://purl.uniprot.org/uniprot/Q0W940 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/351160:RCI_RS12060 ^@ http://purl.uniprot.org/uniprot/Q0W770 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/351160:RCI_RS00300 ^@ http://purl.uniprot.org/uniprot/Q0W083 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/351160:RCI_RS02725 ^@ http://purl.uniprot.org/uniprot/Q0W1K5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.|||Cell inner membrane|||Mediates magnesium influx to the cytosol.|||Membrane http://togogenome.org/gene/351160:RCI_RS14720 ^@ http://purl.uniprot.org/uniprot/Q0W8P2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSL4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. http://togogenome.org/gene/351160:RCI_RS10405 ^@ http://purl.uniprot.org/uniprot/Q0W674 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/351160:RCI_RS02365 ^@ http://purl.uniprot.org/uniprot/Q0W1C9 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/351160:RCI_RS04215 ^@ http://purl.uniprot.org/uniprot/Q0W2G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal histone HMF family.|||Chromosome|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS14615 ^@ http://purl.uniprot.org/uniprot/Q0W8M3 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/351160:RCI_RS12435 ^@ http://purl.uniprot.org/uniprot/Q0W7E7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS11100 ^@ http://purl.uniprot.org/uniprot/Q0W6M1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mer family.|||Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS14890 ^@ http://purl.uniprot.org/uniprot/Q0W8S5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/351160:RCI_RS01790 ^@ http://purl.uniprot.org/uniprot/Q0W120 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the thiamine-monophosphate kinase family.|||Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. http://togogenome.org/gene/351160:RCI_RS09735 ^@ http://purl.uniprot.org/uniprot/Q0W5T9 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/351160:RCI_RS00930 ^@ http://purl.uniprot.org/uniprot/Q0W0K7 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS07760 ^@ http://purl.uniprot.org/uniprot/Q0W4L5 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/351160:RCI_RS03350 ^@ http://purl.uniprot.org/uniprot/Q0W1Y4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/351160:RCI_RS05035 ^@ http://purl.uniprot.org/uniprot/Q0W2Y3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/351160:RCI_RS06645 ^@ http://purl.uniprot.org/uniprot/Q0W3W6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS05315 ^@ http://purl.uniprot.org/uniprot/Q0W340 ^@ Similarity|||Subunit ^@ Belongs to the methyl-coenzyme M reductase gamma subunit family.|||Hexamer of two alpha, two beta, and two gamma chains.|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers. http://togogenome.org/gene/351160:RCI_RS05950 ^@ http://purl.uniprot.org/uniprot/Q0W3H3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS06435 ^@ http://purl.uniprot.org/uniprot/Q0W3S4 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/351160:RCI_RS14240 ^@ http://purl.uniprot.org/uniprot/Q0W8F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS09155 ^@ http://purl.uniprot.org/uniprot/Q0W5G8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS19 family.|||May be involved in maturation of the 30S ribosomal subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/351160:RCI_RS12400 ^@ http://purl.uniprot.org/uniprot/Q0W7E0 ^@ Function|||Miscellaneous|||Similarity ^@ Belongs to the L-aspartate dehydrogenase family.|||Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.|||The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia. http://togogenome.org/gene/351160:RCI_RS05295 ^@ http://purl.uniprot.org/uniprot/Q0W336 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrC family.|||Cell membrane|||Membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/351160:RCI_RS00710 ^@ http://purl.uniprot.org/uniprot/Q0W0G2 ^@ Similarity ^@ In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family. http://togogenome.org/gene/351160:RCI_RS12515 ^@ http://purl.uniprot.org/uniprot/Q0W7G4 ^@ Similarity ^@ Belongs to the glucose-1-phosphate thymidylyltransferase family. http://togogenome.org/gene/351160:RCI_RS00830 ^@ http://purl.uniprot.org/uniprot/Q0W0I6 ^@ Cofactor|||Function|||Subunit ^@ Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.|||Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/351160:RCI_RS12855 ^@ http://purl.uniprot.org/uniprot/Q0W7N1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS12085 ^@ http://purl.uniprot.org/uniprot/Q0W775 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/351160:RCI_RS03310 ^@ http://purl.uniprot.org/uniprot/Q0W1X6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/351160:RCI_RS10555 ^@ http://purl.uniprot.org/uniprot/Q0W6A6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS11530 ^@ http://purl.uniprot.org/uniprot/Q0W6W1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS13475 ^@ http://purl.uniprot.org/uniprot/Q0W806 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. http://togogenome.org/gene/351160:RCI_RS11340 ^@ http://purl.uniprot.org/uniprot/Q0W6S2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS01335 ^@ http://purl.uniprot.org/uniprot/Q0W0T3 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.|||Cell membrane|||Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Membrane|||Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function. http://togogenome.org/gene/351160:RCI_RS00545 ^@ http://purl.uniprot.org/uniprot/Q0W0D0 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/351160:RCI_RS13065 ^@ http://purl.uniprot.org/uniprot/Q0W7S3 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/351160:RCI_RS04985 ^@ http://purl.uniprot.org/uniprot/Q0W2X4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily.|||Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS14135 ^@ http://purl.uniprot.org/uniprot/Q0W8D0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/351160:RCI_RS14710 ^@ http://purl.uniprot.org/uniprot/Q0W8P0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aTrm56 family.|||Cytoplasm|||Homodimer.|||Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs. http://togogenome.org/gene/351160:RCI_RS03765 ^@ http://purl.uniprot.org/uniprot/Q0W272 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS12520 ^@ http://purl.uniprot.org/uniprot/Q0W7G5 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/351160:RCI_RS08290 ^@ http://purl.uniprot.org/uniprot/Q0W4X2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||S-layer http://togogenome.org/gene/351160:RCI_RS04975 ^@ http://purl.uniprot.org/uniprot/Q0W2X2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||S-layer http://togogenome.org/gene/351160:RCI_RS05475 ^@ http://purl.uniprot.org/uniprot/Q0W371 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/351160:RCI_RS13930 ^@ http://purl.uniprot.org/uniprot/Q0W893 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/351160:RCI_RS09705 ^@ http://purl.uniprot.org/uniprot/Q0W5T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS10885 ^@ http://purl.uniprot.org/uniprot/Q0W6H4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.|||Monomer.|||The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity. http://togogenome.org/gene/351160:RCI_RS04445 ^@ http://purl.uniprot.org/uniprot/Q0W2L4 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/351160:RCI_RS10475 ^@ http://purl.uniprot.org/uniprot/Q0W688 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase Z family.|||Binds 2 Zn(2+) ions.|||Homodimer.|||Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. http://togogenome.org/gene/351160:RCI_RS04085 ^@ http://purl.uniprot.org/uniprot/Q0W2E2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Belongs to the NnrE/AIBP family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Homotetramer.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS08170 ^@ http://purl.uniprot.org/uniprot/Q0W4U8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Cell membrane|||Involved in protein export.|||Membrane|||Part of the protein translocation apparatus. Forms a complex with SecF. http://togogenome.org/gene/351160:RCI_RS14300 ^@ http://purl.uniprot.org/uniprot/Q0W8G2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/351160:RCI_RS03840 ^@ http://purl.uniprot.org/uniprot/Q0W289 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS00690 ^@ http://purl.uniprot.org/uniprot/Q0W0F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS00685 ^@ http://purl.uniprot.org/uniprot/Q0W0F7 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/351160:RCI_RS00045 ^@ http://purl.uniprot.org/uniprot/Q0W033 ^@ Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/351160:RCI_RS12405 ^@ http://purl.uniprot.org/uniprot/Q0W7E1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NadC/ModD family.|||Hexamer formed by 3 homodimers.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/351160:RCI_RS06215 ^@ http://purl.uniprot.org/uniprot/Q0W3M8 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/351160:RCI_RS03085 ^@ http://purl.uniprot.org/uniprot/Q0W1T2 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/351160:RCI_RS14315 ^@ http://purl.uniprot.org/uniprot/Q0W8G5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Part of the 30S ribosomal subunit.|||With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. http://togogenome.org/gene/351160:RCI_RS12185 ^@ http://purl.uniprot.org/uniprot/Q0W796 ^@ Similarity ^@ Belongs to the UPF0146 family. http://togogenome.org/gene/351160:RCI_RS14700 ^@ http://purl.uniprot.org/uniprot/Q0W8N8 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the TFE family.|||Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.|||The winged helix domain is involved in binding to DNA in the preinitiation complex.|||Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes. http://togogenome.org/gene/351160:RCI_RS10960 ^@ http://purl.uniprot.org/uniprot/Q0W6J0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HdrA family.|||Cytoplasm|||Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).|||The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC. http://togogenome.org/gene/351160:RCI_RS03415 ^@ http://purl.uniprot.org/uniprot/Q0W1Z9 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/351160:RCI_RS11250 ^@ http://purl.uniprot.org/uniprot/Q0W6Q2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer. http://togogenome.org/gene/351160:RCI_RS07645 ^@ http://purl.uniprot.org/uniprot/Q0W4I7 ^@ Similarity ^@ In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/351160:RCI_RS14145 ^@ http://purl.uniprot.org/uniprot/Q0W8D2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/351160:RCI_RS14100 ^@ http://purl.uniprot.org/uniprot/Q0W8C4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL18 family. http://togogenome.org/gene/351160:RCI_RS04980 ^@ http://purl.uniprot.org/uniprot/Q0W2X3 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/351160:RCI_RS06380 ^@ http://purl.uniprot.org/uniprot/Q0W3R1 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/351160:RCI_RS00700 ^@ http://purl.uniprot.org/uniprot/Q0W0G0 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/351160:RCI_RS06660 ^@ http://purl.uniprot.org/uniprot/Q0W3W9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS13835 ^@ http://purl.uniprot.org/uniprot/Q0W874 ^@ Function|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family. http://togogenome.org/gene/351160:RCI_RS05450 ^@ http://purl.uniprot.org/uniprot/Q0W367 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane http://togogenome.org/gene/351160:RCI_RS03300 ^@ http://purl.uniprot.org/uniprot/Q0W1X4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/351160:RCI_RS03785 ^@ http://purl.uniprot.org/uniprot/Q0W276 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/351160:RCI_RS08365 ^@ http://purl.uniprot.org/uniprot/Q0W4Z0 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/351160:RCI_RS09710 ^@ http://purl.uniprot.org/uniprot/Q0W5T4 ^@ Similarity|||Subunit ^@ Belongs to the ALAD family.|||Homooctamer. http://togogenome.org/gene/351160:RCI_RS14205 ^@ http://purl.uniprot.org/uniprot/Q0W8E4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta-RFA-P synthase family.|||Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).|||Homodimer. http://togogenome.org/gene/351160:RCI_RS14345 ^@ http://purl.uniprot.org/uniprot/Q0W8H1 ^@ Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Part of the RNA polymerase complex. http://togogenome.org/gene/351160:RCI_RS06205 ^@ http://purl.uniprot.org/uniprot/Q0W3M6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC-2 integral membrane protein family. Lipooligosaccharide exporter (TC 3.A.1.102) subfamily.|||Membrane|||Part of the ABC transporter complex NodIJ involved in the export of the nodulation factors (Nod factors), the bacterial signal molecules that induce symbiosis and subsequent nodulation induction. Nod factors are LCO (lipo-chitin oligosaccharide), a modified beta-1,4-linked N-acetylglucosamine oligosaccharide. This subunit encodes the transporter.|||The complex is composed of two ATP-binding proteins (NodI) and two transmembrane proteins (NodJ). http://togogenome.org/gene/351160:RCI_RS03760 ^@ http://purl.uniprot.org/uniprot/Q0W5A4 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/351160:RCI_RS06995 ^@ http://purl.uniprot.org/uniprot/Q0W440 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NifD/NifK/NifE/NifN family.|||Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).|||This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation. http://togogenome.org/gene/351160:RCI_RS04065 ^@ http://purl.uniprot.org/uniprot/Q0W2D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/351160:RCI_RS01750 ^@ http://purl.uniprot.org/uniprot/Q0W112 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the transcriptional regulatory CopG/NikR family.|||Binds 1 nickel ion per subunit.|||Transcriptional regulator. http://togogenome.org/gene/351160:RCI_RS09975 ^@ http://purl.uniprot.org/uniprot/Q0W5Y9 ^@ Similarity ^@ Belongs to the UPF0215 family. http://togogenome.org/gene/351160:RCI_RS04440 ^@ http://purl.uniprot.org/uniprot/Q0W2L3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SepCysS family.|||Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).|||Homodimer. Interacts with SepRS. http://togogenome.org/gene/351160:RCI_RS06580 ^@ http://purl.uniprot.org/uniprot/Q0W3V4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS11120 ^@ http://purl.uniprot.org/uniprot/Q0W6M5 ^@ Function|||Similarity ^@ Acts on leucine, isoleucine and valine.|||Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/351160:RCI_RS09635 ^@ http://purl.uniprot.org/uniprot/Q0W5R8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/351160:RCI_RS05010 ^@ http://purl.uniprot.org/uniprot/Q0W2X8 ^@ Similarity ^@ Belongs to the FrhG family. http://togogenome.org/gene/351160:RCI_RS02675 ^@ http://purl.uniprot.org/uniprot/Q0W1J5 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. http://togogenome.org/gene/351160:RCI_RS04540 ^@ http://purl.uniprot.org/uniprot/Q0W2N3 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/351160:RCI_RS12310 ^@ http://purl.uniprot.org/uniprot/Q0W7C2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS05330 ^@ http://purl.uniprot.org/uniprot/Q0W343 ^@ Similarity|||Subunit ^@ Belongs to the methyl-coenzyme M reductase beta subunit family.|||Hexamer of two alpha, two beta, and two gamma chains.|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers. http://togogenome.org/gene/351160:RCI_RS07860 ^@ http://purl.uniprot.org/uniprot/Q0W4N4 ^@ Similarity ^@ Belongs to the HypD family. http://togogenome.org/gene/351160:RCI_RS13620 ^@ http://purl.uniprot.org/uniprot/Q0W834 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. http://togogenome.org/gene/351160:RCI_RS11035 ^@ http://purl.uniprot.org/uniprot/Q0W6K7 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/351160:RCI_RS13970 ^@ http://purl.uniprot.org/uniprot/Q0W899 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HdrA family.|||Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).|||The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC. http://togogenome.org/gene/351160:RCI_RS09700 ^@ http://purl.uniprot.org/uniprot/Q0W5T2 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethane group. http://togogenome.org/gene/351160:RCI_RS13035 ^@ http://purl.uniprot.org/uniprot/Q0W7R7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS02265 ^@ http://purl.uniprot.org/uniprot/Q0W1B4 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. http://togogenome.org/gene/351160:RCI_RS02775 ^@ http://purl.uniprot.org/uniprot/Q0W1L5 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/351160:RCI_RS13130 ^@ http://purl.uniprot.org/uniprot/Q0W7T6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. http://togogenome.org/gene/351160:RCI_RS00115 ^@ http://purl.uniprot.org/uniprot/Q0W048 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SPT5 family.|||Belongs to the archaeal Spt5 family.|||Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).|||Stimulates transcription elongation. http://togogenome.org/gene/351160:RCI_RS12460 ^@ http://purl.uniprot.org/uniprot/Q0W7F2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS02835 ^@ http://purl.uniprot.org/uniprot/Q0W1M9 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/351160:RCI_RS14095 ^@ http://purl.uniprot.org/uniprot/Q0W8C3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/351160:RCI_RS01565 ^@ http://purl.uniprot.org/uniprot/Q0W0Y2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS00770 ^@ http://purl.uniprot.org/uniprot/Q0W0H5 ^@ Similarity ^@ Belongs to the SIS family. PHI subfamily. http://togogenome.org/gene/351160:RCI_RS02810 ^@ http://purl.uniprot.org/uniprot/Q0W1M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA-PH family.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS05310 ^@ http://purl.uniprot.org/uniprot/Q0W339 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the methyl-coenzyme M reductase alpha subunit family.|||Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.|||Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.|||Hexamer of two alpha, two beta, and two gamma chains.|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers. http://togogenome.org/gene/351160:RCI_RS05665 ^@ http://purl.uniprot.org/uniprot/Q0W3B0 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/351160:RCI_RS12160 ^@ http://purl.uniprot.org/uniprot/Q0W791 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/351160:RCI_RS01100 ^@ http://purl.uniprot.org/uniprot/Q0W0N8 ^@ Similarity ^@ Belongs to the AdoMet synthase family. http://togogenome.org/gene/351160:RCI_RS01525 ^@ http://purl.uniprot.org/uniprot/Q0W0X1 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent DNA ligase family.|||DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. http://togogenome.org/gene/351160:RCI_RS09470 ^@ http://purl.uniprot.org/uniprot/Q0W5N4 ^@ Similarity ^@ Belongs to the HsdR family. http://togogenome.org/gene/351160:RCI_RS07320 ^@ http://purl.uniprot.org/uniprot/Q0W4B4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS10415 ^@ http://purl.uniprot.org/uniprot/Q0W676 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapB family.|||Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. http://togogenome.org/gene/351160:RCI_RS03290 ^@ http://purl.uniprot.org/uniprot/Q0W1X2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/351160:RCI_RS14855 ^@ http://purl.uniprot.org/uniprot/Q0W8R9 ^@ Similarity ^@ Belongs to the snRNP Sm proteins family. http://togogenome.org/gene/351160:RCI_RS04210 ^@ http://purl.uniprot.org/uniprot/Q0W2G8 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily. http://togogenome.org/gene/351160:RCI_RS04375 ^@ http://purl.uniprot.org/uniprot/Q0W2K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal NMN adenylyltransferase family.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS11135 ^@ http://purl.uniprot.org/uniprot/Q0W6M8 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/351160:RCI_RS04315 ^@ http://purl.uniprot.org/uniprot/Q0W2J0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS02220 ^@ http://purl.uniprot.org/uniprot/Q0W1A5 ^@ Similarity ^@ Belongs to the DMRL synthase family. http://togogenome.org/gene/351160:RCI_RS14245 ^@ http://purl.uniprot.org/uniprot/Q0W8F2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS08570 ^@ http://purl.uniprot.org/uniprot/Q0W534 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/351160:RCI_RS02390 ^@ http://purl.uniprot.org/uniprot/Q0W1D4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/351160:RCI_RS04815 ^@ http://purl.uniprot.org/uniprot/Q0W2U1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS14675 ^@ http://purl.uniprot.org/uniprot/Q0W8N3 ^@ Similarity ^@ Belongs to the archaeosine synthase type 1 family. http://togogenome.org/gene/351160:RCI_RS13155 ^@ http://purl.uniprot.org/uniprot/Q0W7U2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS15285 ^@ http://purl.uniprot.org/uniprot/Q0W8Y4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS10245 ^@ http://purl.uniprot.org/uniprot/Q0W644 ^@ Function|||Similarity ^@ Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.|||Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.|||In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.|||In the N-terminal section; belongs to the formaldehyde-activating enzyme family. http://togogenome.org/gene/351160:RCI_RS12440 ^@ http://purl.uniprot.org/uniprot/Q0W7E8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS03220 ^@ http://purl.uniprot.org/uniprot/Q0W1V9 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/351160:RCI_RS14295 ^@ http://purl.uniprot.org/uniprot/Q0W8G1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/351160:RCI_RS14810 ^@ http://purl.uniprot.org/uniprot/Q0W8R0 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/351160:RCI_RS11495 ^@ http://purl.uniprot.org/uniprot/Q0W6V4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. CofH family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.|||Consists of two subunits, CofG and CofH. http://togogenome.org/gene/351160:RCI_RS03955 ^@ http://purl.uniprot.org/uniprot/Q0W2B4 ^@ Similarity ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. http://togogenome.org/gene/351160:RCI_RS07905 ^@ http://purl.uniprot.org/uniprot/Q0W4P3 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS00790 ^@ http://purl.uniprot.org/uniprot/Q0W0H9 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.|||Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction proceeds via a cis-phosphoenolate intermediate. http://togogenome.org/gene/351160:RCI_RS08770 ^@ http://purl.uniprot.org/uniprot/Q0W588 ^@ Similarity ^@ In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.|||In the central section; belongs to the CRISPR-associated helicase Cas3 family. http://togogenome.org/gene/351160:RCI_RS09560 ^@ http://purl.uniprot.org/uniprot/Q0W5Q2 ^@ Similarity ^@ Belongs to the peptidase C56 family. http://togogenome.org/gene/351160:RCI_RS12955 ^@ http://purl.uniprot.org/uniprot/Q0W7Q1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS03250 ^@ http://purl.uniprot.org/uniprot/Q0W1W4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.|||Cytoplasm|||Monomer. http://togogenome.org/gene/351160:RCI_RS13560 ^@ http://purl.uniprot.org/uniprot/Q0W823 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/351160:RCI_RS14305 ^@ http://purl.uniprot.org/uniprot/Q0W8G3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS11085 ^@ http://purl.uniprot.org/uniprot/Q0W6L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS02790 ^@ http://purl.uniprot.org/uniprot/Q0W1L9 ^@ Function|||Similarity ^@ Belongs to the Thz kinase family.|||Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ). http://togogenome.org/gene/351160:RCI_RS03280 ^@ http://purl.uniprot.org/uniprot/Q0W1X0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/351160:RCI_RS13175 ^@ http://purl.uniprot.org/uniprot/Q0W7U6 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/351160:RCI_RS02860 ^@ http://purl.uniprot.org/uniprot/Q0W1N4 ^@ Function|||Similarity ^@ Belongs to the CobB/CobQ family. CobQ subfamily.|||Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. http://togogenome.org/gene/351160:RCI_RS03240 ^@ http://purl.uniprot.org/uniprot/Q0W1W2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS05855 ^@ http://purl.uniprot.org/uniprot/Q0W3F3 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/351160:RCI_RS05425 ^@ http://purl.uniprot.org/uniprot/Q0W362 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. http://togogenome.org/gene/351160:RCI_RS11590 ^@ http://purl.uniprot.org/uniprot/Q0W6X3 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/351160:RCI_RS05125 ^@ http://purl.uniprot.org/uniprot/Q0W302 ^@ Function|||Similarity ^@ Belongs to the TFIIB family.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/351160:RCI_RS11025 ^@ http://purl.uniprot.org/uniprot/Q0W6K5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GGGP/HepGP synthase family. Group I subfamily.|||Cytoplasm|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/351160:RCI_RS04105 ^@ http://purl.uniprot.org/uniprot/Q0W2E6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/351160:RCI_RS00135 ^@ http://purl.uniprot.org/uniprot/Q0W052 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/351160:RCI_RS13195 ^@ http://purl.uniprot.org/uniprot/Q0W7V0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS06520 ^@ http://purl.uniprot.org/uniprot/Q0W3U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal histone HMF family.|||Chromosome|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS01845 ^@ http://purl.uniprot.org/uniprot/Q0W131 ^@ Function|||Similarity ^@ Belongs to the archaeal-type DHQ synthase family.|||Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis. http://togogenome.org/gene/351160:RCI_RS05060 ^@ http://purl.uniprot.org/uniprot/Q0W2Y8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp41 subfamily.|||Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS10855 ^@ http://purl.uniprot.org/uniprot/Q0W6G9 ^@ Similarity ^@ Belongs to the catalase family. http://togogenome.org/gene/351160:RCI_RS06480 ^@ http://purl.uniprot.org/uniprot/Q0W3T3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/351160:RCI_RS10900 ^@ http://purl.uniprot.org/uniprot/Q0W6H8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 4 family.|||Binds 1 zinc ion per subunit.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/351160:RCI_RS00270 ^@ http://purl.uniprot.org/uniprot/Q0W077 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/351160:RCI_RS14215 ^@ http://purl.uniprot.org/uniprot/Q0W8E6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyltransferase superfamily. Fibrillarin family.|||Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.|||Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. http://togogenome.org/gene/351160:RCI_RS01090 ^@ http://purl.uniprot.org/uniprot/Q0W0N6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/351160:RCI_RS02520 ^@ http://purl.uniprot.org/uniprot/Q0W1G1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCH family.|||Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS03670 ^@ http://purl.uniprot.org/uniprot/Q0W252 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.|||Belongs to the histone-like Alba family.|||Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.|||Chromosome|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/351160:RCI_RS14395 ^@ http://purl.uniprot.org/uniprot/Q0W8H9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS12710 ^@ http://purl.uniprot.org/uniprot/Q0W7K1 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. UPF0219 family. http://togogenome.org/gene/351160:RCI_RS03320 ^@ http://purl.uniprot.org/uniprot/Q0W1X8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges. http://togogenome.org/gene/351160:RCI_RS14990 ^@ http://purl.uniprot.org/uniprot/Q0W8U5 ^@ Similarity ^@ Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. http://togogenome.org/gene/351160:RCI_RS09235 ^@ http://purl.uniprot.org/uniprot/Q0W5I3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrI family.|||Binds 1 zinc ion per subunit.|||Contains catalytic and regulatory chains.|||Involved in allosteric regulation of aspartate carbamoyltransferase. http://togogenome.org/gene/351160:RCI_RS11550 ^@ http://purl.uniprot.org/uniprot/Q0W6W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/351160:RCI_RS14430 ^@ http://purl.uniprot.org/uniprot/Q0W8I5 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. http://togogenome.org/gene/351160:RCI_RS14835 ^@ http://purl.uniprot.org/uniprot/Q0W8R5 ^@ Similarity ^@ Belongs to the UPF0284 family. http://togogenome.org/gene/351160:RCI_RS09605 ^@ http://purl.uniprot.org/uniprot/Q0W5R2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS11310 ^@ http://purl.uniprot.org/uniprot/Q0W6R5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/351160:RCI_RS04345 ^@ http://purl.uniprot.org/uniprot/Q0W2J4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. http://togogenome.org/gene/351160:RCI_RS10910 ^@ http://purl.uniprot.org/uniprot/Q0W6I0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity). http://togogenome.org/gene/351160:RCI_RS04415 ^@ http://purl.uniprot.org/uniprot/Q0W2K9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS1 family. http://togogenome.org/gene/351160:RCI_RS07195 ^@ http://purl.uniprot.org/uniprot/Q0W485 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/351160:RCI_RS05065 ^@ http://purl.uniprot.org/uniprot/Q0W2Y9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRP4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. http://togogenome.org/gene/351160:RCI_RS15550 ^@ http://purl.uniprot.org/uniprot/Q0W938 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/351160:RCI_RS00030 ^@ http://purl.uniprot.org/uniprot/Q0W030 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/351160:RCI_RS10365 ^@ http://purl.uniprot.org/uniprot/Q0W669 ^@ Similarity ^@ Belongs to the CutA family. http://togogenome.org/gene/351160:RCI_RS15565 ^@ http://purl.uniprot.org/uniprot/Q0W941 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Cytoplasm|||Functions by promoting the formation of the first peptide bond. http://togogenome.org/gene/351160:RCI_RS05005 ^@ http://purl.uniprot.org/uniprot/Q0W2X7 ^@ Similarity ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. http://togogenome.org/gene/351160:RCI_RS12240 ^@ http://purl.uniprot.org/uniprot/Q0W7A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS07300 ^@ http://purl.uniprot.org/uniprot/Q0W4A9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS14140 ^@ http://purl.uniprot.org/uniprot/Q0W8D1 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/351160:RCI_RS04590 ^@ http://purl.uniprot.org/uniprot/Q0W2P3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. http://togogenome.org/gene/351160:RCI_RS03195 ^@ http://purl.uniprot.org/uniprot/Q0W1V4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/351160:RCI_RS13125 ^@ http://purl.uniprot.org/uniprot/Q0W7T5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).|||Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS04335 ^@ http://purl.uniprot.org/uniprot/Q0W2J3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. http://togogenome.org/gene/351160:RCI_RS05485 ^@ http://purl.uniprot.org/uniprot/Q0W373 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.|||Nucleus|||Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure. http://togogenome.org/gene/351160:RCI_RS03360 ^@ http://purl.uniprot.org/uniprot/Q0W1Y6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/351160:RCI_RS04695 ^@ http://purl.uniprot.org/uniprot/Q0W2R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS13535 ^@ http://purl.uniprot.org/uniprot/Q0W818 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/351160:RCI_RS00425 ^@ http://purl.uniprot.org/uniprot/Q0W0A6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS00650 ^@ http://purl.uniprot.org/uniprot/Q0W0F0 ^@ Caution|||Function|||Similarity ^@ Belongs to the Nre family.|||Involved in DNA damage repair.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS15520 ^@ http://purl.uniprot.org/uniprot/Q0W932 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS11020 ^@ http://purl.uniprot.org/uniprot/Q0W6K4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GGGP/HepGP synthase family. Group I subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/351160:RCI_RS11040 ^@ http://purl.uniprot.org/uniprot/Q0W6K8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).|||Belongs to the TDD superfamily. TSR3 family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS08860 ^@ http://purl.uniprot.org/uniprot/Q0W5A8 ^@ Function|||Similarity ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.|||Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. http://togogenome.org/gene/351160:RCI_RS04100 ^@ http://purl.uniprot.org/uniprot/Q0W2E5 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/351160:RCI_RS05195 ^@ http://purl.uniprot.org/uniprot/Q0W315 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/351160:RCI_RS04960 ^@ http://purl.uniprot.org/uniprot/Q0W2W9 ^@ Function|||Similarity ^@ Belongs to the KptA/TPT1 family.|||Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase. http://togogenome.org/gene/351160:RCI_RS01940 ^@ http://purl.uniprot.org/uniprot/Q0W150 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS02495 ^@ http://purl.uniprot.org/uniprot/Q0W1F6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/351160:RCI_RS08430 ^@ http://purl.uniprot.org/uniprot/Q0W503 ^@ Caution|||Function|||Similarity ^@ Belongs to the TBP family.|||General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS09175 ^@ http://purl.uniprot.org/uniprot/Q0W5H1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family. http://togogenome.org/gene/351160:RCI_RS07200 ^@ http://purl.uniprot.org/uniprot/Q0W486 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SepCysS family.|||Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).|||Homodimer. Interacts with SepRS. http://togogenome.org/gene/351160:RCI_RS06365 ^@ http://purl.uniprot.org/uniprot/Q0W3Q8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS02135 ^@ http://purl.uniprot.org/uniprot/Q0W189 ^@ Similarity ^@ Belongs to the DeoC/FbaB aldolase family. http://togogenome.org/gene/351160:RCI_RS06150 ^@ http://purl.uniprot.org/uniprot/Q0W3L4 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/351160:RCI_RS05565 ^@ http://purl.uniprot.org/uniprot/Q0W390 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/351160:RCI_RS04175 ^@ http://purl.uniprot.org/uniprot/Q0W2G1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/351160:RCI_RS11105 ^@ http://purl.uniprot.org/uniprot/Q0W6M2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.|||Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS04600 ^@ http://purl.uniprot.org/uniprot/Q0W2P5 ^@ Function|||Similarity ^@ Belongs to the MTD family.|||Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. http://togogenome.org/gene/351160:RCI_RS10830 ^@ http://purl.uniprot.org/uniprot/Q0W6G4 ^@ Function|||Similarity ^@ Belongs to the GTP-dependent DPCK family.|||Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). http://togogenome.org/gene/351160:RCI_RS04250 ^@ http://purl.uniprot.org/uniprot/Q0W2H7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the rubredoxin family.|||Binds 1 Fe(3+) ion per subunit.|||Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule. http://togogenome.org/gene/351160:RCI_RS07985 ^@ http://purl.uniprot.org/uniprot/Q0W4R1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS01770 ^@ http://purl.uniprot.org/uniprot/Q0W116 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS06295 ^@ http://purl.uniprot.org/uniprot/Q0W3P4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcL subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/351160:RCI_RS07700 ^@ http://purl.uniprot.org/uniprot/Q0W4K2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC61-beta family.|||Cell membrane|||Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.|||Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex. http://togogenome.org/gene/351160:RCI_RS15525 ^@ http://purl.uniprot.org/uniprot/Q0W933 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal FAD synthase family.|||Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.|||Homodimer. http://togogenome.org/gene/351160:RCI_RS02160 ^@ http://purl.uniprot.org/uniprot/Q0W193 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS05435 ^@ http://purl.uniprot.org/uniprot/Q0W364 ^@ Function|||Similarity ^@ Belongs to the V-ATPase F subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/351160:RCI_RS09585 ^@ http://purl.uniprot.org/uniprot/Q0W5Q7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamine synthetase family.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS12235 ^@ http://purl.uniprot.org/uniprot/Q0W7A3 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the asparaginase 1 family. GatD subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/351160:RCI_RS04080 ^@ http://purl.uniprot.org/uniprot/Q0W2E1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/351160:RCI_RS08340 ^@ http://purl.uniprot.org/uniprot/Q0W4Y5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Forms a complex with TatA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/351160:RCI_RS05285 ^@ http://purl.uniprot.org/uniprot/Q0W334 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrA family.|||Binds 1 5-hydroxybenzimidazolylcobamide group.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/351160:RCI_RS05525 ^@ http://purl.uniprot.org/uniprot/Q0W382 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CbiX family. CbiXS subfamily.|||Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.|||Homotetramer; dimer of dimers. http://togogenome.org/gene/351160:RCI_RS15390 ^@ http://purl.uniprot.org/uniprot/Q0W905 ^@ Similarity ^@ Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. http://togogenome.org/gene/351160:RCI_RS02215 ^@ http://purl.uniprot.org/uniprot/Q0W1A4 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/351160:RCI_RS14780 ^@ http://purl.uniprot.org/uniprot/Q0W8Q4 ^@ Similarity ^@ Belongs to the SIS family. PHI subfamily. http://togogenome.org/gene/351160:RCI_RS03295 ^@ http://purl.uniprot.org/uniprot/Q0W1X3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/351160:RCI_RS08665 ^@ http://purl.uniprot.org/uniprot/Q0W552 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A single active site specifically recognizes both ATP and CTP and is responsible for their addition.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.|||Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.|||Homodimer. http://togogenome.org/gene/351160:RCI_RS15045 ^@ http://purl.uniprot.org/uniprot/Q0W8V5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta-RFA-P synthase family.|||Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).|||Homodimer. http://togogenome.org/gene/351160:RCI_RS08635 ^@ http://purl.uniprot.org/uniprot/Q0W546 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/351160:RCI_RS03285 ^@ http://purl.uniprot.org/uniprot/Q0W1X1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/351160:RCI_RS14470 ^@ http://purl.uniprot.org/uniprot/Q0W8J3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS08420 ^@ http://purl.uniprot.org/uniprot/Q0W501 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS07265 ^@ http://purl.uniprot.org/uniprot/Q0W4A2 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/351160:RCI_RS01175 ^@ http://purl.uniprot.org/uniprot/Q0W0Q2 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/351160:RCI_RS01285 ^@ http://purl.uniprot.org/uniprot/Q0W0S3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS00540 ^@ http://purl.uniprot.org/uniprot/Q0W0C9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/351160:RCI_RS00335 ^@ http://purl.uniprot.org/uniprot/Q0W089 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS07940 ^@ http://purl.uniprot.org/uniprot/Q0W4Q0 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.|||Cytoplasm|||Homodimer or homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Non-allosteric. http://togogenome.org/gene/351160:RCI_RS00005 ^@ http://purl.uniprot.org/uniprot/Q0W025 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS10140 ^@ http://purl.uniprot.org/uniprot/Q0W622 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS02470 ^@ http://purl.uniprot.org/uniprot/Q0W1F1 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ThiC family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS15125 ^@ http://purl.uniprot.org/uniprot/Q0W945 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS13980 ^@ http://purl.uniprot.org/uniprot/Q0W8A1 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/351160:RCI_RS06955 ^@ http://purl.uniprot.org/uniprot/Q0W432 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS03960 ^@ http://purl.uniprot.org/uniprot/Q0W2B5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS05045 ^@ http://purl.uniprot.org/uniprot/Q0W2Y5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/351160:RCI_RS03365 ^@ http://purl.uniprot.org/uniprot/Q0W1Y7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29. http://togogenome.org/gene/351160:RCI_RS03650 ^@ http://purl.uniprot.org/uniprot/Q0W248 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/351160:RCI_RS01295 ^@ http://purl.uniprot.org/uniprot/Q0W0S5 ^@ Cofactor ^@ Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/351160:RCI_RS13250 ^@ http://purl.uniprot.org/uniprot/Q0W7W0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/351160:RCI_RS05835 ^@ http://purl.uniprot.org/uniprot/Q0W3E9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/351160:RCI_RS02900 ^@ http://purl.uniprot.org/uniprot/Q0W1P3 ^@ Function ^@ Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin. http://togogenome.org/gene/351160:RCI_RS10965 ^@ http://purl.uniprot.org/uniprot/Q0W6J1 ^@ Similarity ^@ Belongs to the HdrB family. http://togogenome.org/gene/351160:RCI_RS10580 ^@ http://purl.uniprot.org/uniprot/Q0W6B2 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/351160:RCI_RS05340 ^@ http://purl.uniprot.org/uniprot/Q0W345 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/351160:RCI_RS05545 ^@ http://purl.uniprot.org/uniprot/Q0W386 ^@ Domain|||Function|||Miscellaneous|||Similarity ^@ Belongs to the CobB/CbiA family.|||Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.|||Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.|||The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate. http://togogenome.org/gene/351160:RCI_RS10500 ^@ http://purl.uniprot.org/uniprot/Q0W694 ^@ Similarity ^@ Belongs to the UPF0200 family.|||Belongs to the UPF0201 family. http://togogenome.org/gene/351160:RCI_RS02350 ^@ http://purl.uniprot.org/uniprot/Q0W1C7 ^@ Cofactor|||Similarity ^@ Belongs to the PdaD family.|||Binds 1 pyruvoyl group covalently per subunit. http://togogenome.org/gene/351160:RCI_RS05050 ^@ http://purl.uniprot.org/uniprot/Q0W2Y6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/351160:RCI_RS05055 ^@ http://purl.uniprot.org/uniprot/Q0W2Y7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp42 subfamily.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. http://togogenome.org/gene/351160:RCI_RS09230 ^@ http://purl.uniprot.org/uniprot/Q0W5I2 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.|||Heterooligomer of catalytic and regulatory chains. http://togogenome.org/gene/351160:RCI_RS05445 ^@ http://purl.uniprot.org/uniprot/Q0W366 ^@ Function|||Similarity ^@ Belongs to the V-ATPase E subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/351160:RCI_RS04075 ^@ http://purl.uniprot.org/uniprot/Q0W2E0 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/351160:RCI_RS03275 ^@ http://purl.uniprot.org/uniprot/Q0W1W9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/351160:RCI_RS06340 ^@ http://purl.uniprot.org/uniprot/Q0W3Q3 ^@ Similarity ^@ Belongs to the transcriptional regulator TrmB family. http://togogenome.org/gene/351160:RCI_RS07110 ^@ http://purl.uniprot.org/uniprot/Q0W468 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/351160:RCI_RS12950 ^@ http://purl.uniprot.org/uniprot/Q0W7Q0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS07115 ^@ http://purl.uniprot.org/uniprot/Q0W469 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. http://togogenome.org/gene/351160:RCI_RS13210 ^@ http://purl.uniprot.org/uniprot/Q0W7V3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRA-CH family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/351160:RCI_RS09650 ^@ http://purl.uniprot.org/uniprot/Q0W5S2 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/351160:RCI_RS01805 ^@ http://purl.uniprot.org/uniprot/Q0W123 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/351160:RCI_RS13840 ^@ http://purl.uniprot.org/uniprot/Q0W875 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/351160:RCI_RS14235 ^@ http://purl.uniprot.org/uniprot/Q0W8F0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS03345 ^@ http://purl.uniprot.org/uniprot/Q0W1Y3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/351160:RCI_RS04635 ^@ http://purl.uniprot.org/uniprot/Q0W2Q3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/351160:RCI_RS11870 ^@ http://purl.uniprot.org/uniprot/Q0W731 ^@ Similarity ^@ Belongs to the MtxX family. http://togogenome.org/gene/351160:RCI_RS04040 ^@ http://purl.uniprot.org/uniprot/Q0W2D2 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.|||Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Homohexamer. Dimer of a homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. http://togogenome.org/gene/351160:RCI_RS12750 ^@ http://purl.uniprot.org/uniprot/Q0W7L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/351160:RCI_RS08110 ^@ http://purl.uniprot.org/uniprot/Q0W4T6 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/351160:RCI_RS04170 ^@ http://purl.uniprot.org/uniprot/Q0W2G0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyltransferase superfamily. TrmY family.|||Cytoplasm|||Homodimer.|||Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs. http://togogenome.org/gene/351160:RCI_RS06990 ^@ http://purl.uniprot.org/uniprot/Q0W439 ^@ Similarity ^@ Belongs to the NifD/NifK/NifE/NifN family. http://togogenome.org/gene/351160:RCI_RS01865 ^@ http://purl.uniprot.org/uniprot/Q0W135 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS10610 ^@ http://purl.uniprot.org/uniprot/Q0W6B8 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/351160:RCI_RS08730 ^@ http://purl.uniprot.org/uniprot/Q0W565 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS05655 ^@ http://purl.uniprot.org/uniprot/Q0W3A8 ^@ Similarity ^@ Belongs to the methylamine corrinoid protein family. http://togogenome.org/gene/351160:RCI_RS07665 ^@ http://purl.uniprot.org/uniprot/Q0W4J1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL40 family. http://togogenome.org/gene/351160:RCI_RS11630 ^@ http://purl.uniprot.org/uniprot/Q0W6Y1 ^@ Similarity ^@ Belongs to the UPF0237 family. http://togogenome.org/gene/351160:RCI_RS03325 ^@ http://purl.uniprot.org/uniprot/Q0W1X9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/351160:RCI_RS05305 ^@ http://purl.uniprot.org/uniprot/Q0W338 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrE family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/351160:RCI_RS14970 ^@ http://purl.uniprot.org/uniprot/Q0W8U1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FTR family.|||Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/351160:RCI_RS02945 ^@ http://purl.uniprot.org/uniprot/Q0W1Q5 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS07750 ^@ http://purl.uniprot.org/uniprot/Q0W4L3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS15205 ^@ http://purl.uniprot.org/uniprot/Q0W8W9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Cytoplasm|||Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.|||Part of the 50S ribosomal subunit. Probably part of the RNase P complex. http://togogenome.org/gene/351160:RCI_RS01340 ^@ http://purl.uniprot.org/uniprot/Q0W0T4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.|||Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).|||Homotetramer. Interacts with SepCysS. http://togogenome.org/gene/351160:RCI_RS03200 ^@ http://purl.uniprot.org/uniprot/Q0W1V5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/351160:RCI_RS03375 ^@ http://purl.uniprot.org/uniprot/Q0W1Y9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e. http://togogenome.org/gene/351160:RCI_RS11260 ^@ http://purl.uniprot.org/uniprot/Q0W6Q4 ^@ Cofactor|||Similarity ^@ Belongs to the GARS family.|||Binds 2 magnesium or manganese ions per subunit. http://togogenome.org/gene/351160:RCI_RS07910 ^@ http://purl.uniprot.org/uniprot/Q0W4P4 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/351160:RCI_RS03875 ^@ http://purl.uniprot.org/uniprot/Q0W296 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/351160:RCI_RS01365 ^@ http://purl.uniprot.org/uniprot/Q0W0T9 ^@ Similarity ^@ Belongs to the LeuD family. LeuD type 2 subfamily. http://togogenome.org/gene/351160:RCI_RS02130 ^@ http://purl.uniprot.org/uniprot/Q0W188 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS13395 ^@ http://purl.uniprot.org/uniprot/Q0W7Y9 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/351160:RCI_RS14155 ^@ http://purl.uniprot.org/uniprot/Q0W8D4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS05360 ^@ http://purl.uniprot.org/uniprot/Q0W349 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.|||Binds 1 FAD per subunit.|||Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.|||Reduction reaction proceeds via syn addition of hydrogen for double bonds. http://togogenome.org/gene/351160:RCI_RS05625 ^@ http://purl.uniprot.org/uniprot/Q0W3A2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/351160:RCI_RS09795 ^@ http://purl.uniprot.org/uniprot/Q0W5V1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS05390 ^@ http://purl.uniprot.org/uniprot/Q0W355 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/351160:RCI_RS14340 ^@ http://purl.uniprot.org/uniprot/Q0W8H0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Cytoplasm|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/351160:RCI_RS15170 ^@ http://purl.uniprot.org/uniprot/Q0W954 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/351160:RCI_RS06910 ^@ http://purl.uniprot.org/uniprot/Q0W423 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS01820 ^@ http://purl.uniprot.org/uniprot/Q0W126 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NucS endonuclease family.|||Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS13770 ^@ http://purl.uniprot.org/uniprot/Q0W861 ^@ Function|||Similarity ^@ Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.|||Belongs to the archease family. http://togogenome.org/gene/351160:RCI_RS01655 ^@ http://purl.uniprot.org/uniprot/Q0W0Z7 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/351160:RCI_RS02875 ^@ http://purl.uniprot.org/uniprot/Q0W1N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/351160:RCI_RS10065 ^@ http://purl.uniprot.org/uniprot/Q0W606 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS04660 ^@ http://purl.uniprot.org/uniprot/Q0W2Q8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS09540 ^@ http://purl.uniprot.org/uniprot/Q0W5P8 ^@ Function|||Similarity ^@ Belongs to the archaeal SPP-like hydrolase family.|||Catalyzes the dephosphorylation of 2-phosphoglycolate. http://togogenome.org/gene/351160:RCI_RS04120 ^@ http://purl.uniprot.org/uniprot/Q0W2E9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/351160:RCI_RS13070 ^@ http://purl.uniprot.org/uniprot/Q0W7S4 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/351160:RCI_RS10035 ^@ http://purl.uniprot.org/uniprot/Q0W600 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS01755 ^@ http://purl.uniprot.org/uniprot/Q0W113 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS07715 ^@ http://purl.uniprot.org/uniprot/Q0W4K5 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/351160:RCI_RS14150 ^@ http://purl.uniprot.org/uniprot/Q0W8D3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the isopentenyl phosphate kinase family.|||Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.|||Homodimer. http://togogenome.org/gene/351160:RCI_RS14110 ^@ http://purl.uniprot.org/uniprot/Q0W8C6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/351160:RCI_RS11155 ^@ http://purl.uniprot.org/uniprot/Q0W6N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/351160:RCI_RS13160 ^@ http://purl.uniprot.org/uniprot/Q0W7U3 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/351160:RCI_RS14715 ^@ http://purl.uniprot.org/uniprot/Q0W8P1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/351160:RCI_RS07775 ^@ http://purl.uniprot.org/uniprot/Q0W4L8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Homodimer.|||Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. http://togogenome.org/gene/351160:RCI_RS03245 ^@ http://purl.uniprot.org/uniprot/Q0W1W3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS02755 ^@ http://purl.uniprot.org/uniprot/Q0W1L1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the archaeosine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs. http://togogenome.org/gene/351160:RCI_RS07250 ^@ http://purl.uniprot.org/uniprot/Q0W499 ^@ Function|||Similarity ^@ Belongs to the PEP-utilizing enzyme family.|||Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. http://togogenome.org/gene/351160:RCI_RS03355 ^@ http://purl.uniprot.org/uniprot/Q0W1Y5 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/351160:RCI_RS05560 ^@ http://purl.uniprot.org/uniprot/Q0W389 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/351160:RCI_RS14565 ^@ http://purl.uniprot.org/uniprot/Q0W8L2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS12230 ^@ http://purl.uniprot.org/uniprot/Q0W7A2 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the GatB/GatE family. GatE subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/351160:RCI_RS08150 ^@ http://purl.uniprot.org/uniprot/Q0W4U4 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/351160:RCI_RS00130 ^@ http://purl.uniprot.org/uniprot/Q0W051 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/351160:RCI_RS12155 ^@ http://purl.uniprot.org/uniprot/Q0W790 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS01300 ^@ http://purl.uniprot.org/uniprot/Q0W0S6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/351160:RCI_RS11015 ^@ http://purl.uniprot.org/uniprot/Q0W6K3 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP phosphoribosyltransferase family. Long subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Feedback inhibited by histidine. http://togogenome.org/gene/351160:RCI_RS14015 ^@ http://purl.uniprot.org/uniprot/Q0W8A8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/351160:RCI_RS02210 ^@ http://purl.uniprot.org/uniprot/Q0W1A3 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/351160:RCI_RS09830 ^@ http://purl.uniprot.org/uniprot/Q0W5V8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Forms a complex with TatA.|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/351160:RCI_RS08145 ^@ http://purl.uniprot.org/uniprot/Q0W4U3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the shikimate dehydrogenase family.|||Homodimer.|||Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). http://togogenome.org/gene/351160:RCI_RS11270 ^@ http://purl.uniprot.org/uniprot/Q0W6Q6 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/351160:RCI_RS08100 ^@ http://purl.uniprot.org/uniprot/Q0W4T3 ^@ Cofactor|||Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/351160:RCI_RS10890 ^@ http://purl.uniprot.org/uniprot/Q0W6H5 ^@ Function|||Similarity|||Subunit ^@ Associates with stalled 50S ribosomal subunits.|||Belongs to the NEMF family.|||Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation. http://togogenome.org/gene/351160:RCI_RS09655 ^@ http://purl.uniprot.org/uniprot/Q0W5S3 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/351160:RCI_RS08310 ^@ http://purl.uniprot.org/uniprot/Q0W4X6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS01700 ^@ http://purl.uniprot.org/uniprot/Q0W106 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS00465 ^@ http://purl.uniprot.org/uniprot/Q0W0B3 ^@ Similarity ^@ Belongs to the SAM hydrolase / SAM-dependent halogenase family. http://togogenome.org/gene/351160:RCI_RS01510 ^@ http://purl.uniprot.org/uniprot/Q0W0W8 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/351160:RCI_RS05320 ^@ http://purl.uniprot.org/uniprot/Q0W341 ^@ Subunit ^@ MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known. http://togogenome.org/gene/351160:RCI_RS10600 ^@ http://purl.uniprot.org/uniprot/Q0W6B6 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/351160:RCI_RS07680 ^@ http://purl.uniprot.org/uniprot/Q0W4J5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.|||Belongs to the TiaS family.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS14620 ^@ http://purl.uniprot.org/uniprot/Q0W8M4 ^@ Similarity ^@ Belongs to the eIF-2-alpha family. http://togogenome.org/gene/351160:RCI_RS11715 ^@ http://purl.uniprot.org/uniprot/Q0W700 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/351160:RCI_RS08850 ^@ http://purl.uniprot.org/uniprot/Q0W5A6 ^@ Function|||Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.|||Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway. http://togogenome.org/gene/351160:RCI_RS07340 ^@ http://purl.uniprot.org/uniprot/Q0W4B8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type-I 3-dehydroquinase family.|||Homodimer.|||Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. http://togogenome.org/gene/351160:RCI_RS09350 ^@ http://purl.uniprot.org/uniprot/Q0W5K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Membrane http://togogenome.org/gene/351160:RCI_RS06860 ^@ http://purl.uniprot.org/uniprot/Q0W413 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.|||Membrane http://togogenome.org/gene/351160:RCI_RS14130 ^@ http://purl.uniprot.org/uniprot/Q0W8C9 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/351160:RCI_RS09185 ^@ http://purl.uniprot.org/uniprot/Q0W5H3 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL20 family.|||Part of the 50S ribosomal subunit. Binds 23S rRNA. http://togogenome.org/gene/351160:RCI_RS05275 ^@ http://purl.uniprot.org/uniprot/Q0W332 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrG family.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/351160:RCI_RS03555 ^@ http://purl.uniprot.org/uniprot/Q0W228 ^@ Similarity ^@ Belongs to the alpha-acetolactate decarboxylase family. http://togogenome.org/gene/351160:RCI_RS10120 ^@ http://purl.uniprot.org/uniprot/Q0W618 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS04605 ^@ http://purl.uniprot.org/uniprot/Q0W2P6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS10430 ^@ http://purl.uniprot.org/uniprot/Q0W678 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS01150 ^@ http://purl.uniprot.org/uniprot/Q0W0P7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS11350 ^@ http://purl.uniprot.org/uniprot/Q0W6S4 ^@ Function|||Similarity ^@ Belongs to the archaeal IMP cyclohydrolase family.|||Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP. http://togogenome.org/gene/351160:RCI_RS00025 ^@ http://purl.uniprot.org/uniprot/Q0W029 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/351160:RCI_RS15460 ^@ http://purl.uniprot.org/uniprot/Q0W920 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/351160:RCI_RS09805 ^@ http://purl.uniprot.org/uniprot/Q0W5V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/351160:RCI_RS14310 ^@ http://purl.uniprot.org/uniprot/Q0W8G4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/351160:RCI_RS06430 ^@ http://purl.uniprot.org/uniprot/Q0W3S3 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/351160:RCI_RS01955 ^@ http://purl.uniprot.org/uniprot/Q0W153 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/351160:RCI_RS11140 ^@ http://purl.uniprot.org/uniprot/Q0W6M9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/351160:RCI_RS02910 ^@ http://purl.uniprot.org/uniprot/Q0W1P5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Cell membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. http://togogenome.org/gene/351160:RCI_RS13830 ^@ http://purl.uniprot.org/uniprot/Q0W873 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/351160:RCI_RS13080 ^@ http://purl.uniprot.org/uniprot/Q0W7S6 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/351160:RCI_RS02380 ^@ http://purl.uniprot.org/uniprot/Q0W1D2 ^@ Cofactor|||Similarity ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/351160:RCI_RS00860 ^@ http://purl.uniprot.org/uniprot/Q0W0J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS15970 ^@ http://purl.uniprot.org/uniprot/Q0W7K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS05830 ^@ http://purl.uniprot.org/uniprot/Q0W3E8 ^@ Similarity ^@ Belongs to the HisA/HisF family. http://togogenome.org/gene/351160:RCI_RS08605 ^@ http://purl.uniprot.org/uniprot/Q0W540 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS06950 ^@ http://purl.uniprot.org/uniprot/Q0W431 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS06545 ^@ http://purl.uniprot.org/uniprot/Q0W3U7 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/351160:RCI_RS08955 ^@ http://purl.uniprot.org/uniprot/Q0W5C7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the YjjX NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Homodimer.|||Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/351160:RCI_RS09670 ^@ http://purl.uniprot.org/uniprot/Q0W5S6 ^@ Subunit ^@ Homotetramer. http://togogenome.org/gene/351160:RCI_RS15585 ^@ http://purl.uniprot.org/uniprot/Q0W0C2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS11570 ^@ http://purl.uniprot.org/uniprot/Q0W6W9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS08205 ^@ http://purl.uniprot.org/uniprot/Q0W4V5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS06705 ^@ http://purl.uniprot.org/uniprot/Q0W3X9 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).|||Cytoplasm|||Homodimer.|||The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself. http://togogenome.org/gene/351160:RCI_RS15160 ^@ http://purl.uniprot.org/uniprot/Q0W952 ^@ Similarity|||Subunit ^@ Belongs to the HTP reductase family.|||Homodimer. http://togogenome.org/gene/351160:RCI_RS04455 ^@ http://purl.uniprot.org/uniprot/Q0W2L6 ^@ Function|||Similarity ^@ Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). http://togogenome.org/gene/351160:RCI_RS08485 ^@ http://purl.uniprot.org/uniprot/Q0W514 ^@ Function ^@ Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. http://togogenome.org/gene/351160:RCI_RS03060 ^@ http://purl.uniprot.org/uniprot/Q0W1S7 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily. http://togogenome.org/gene/351160:RCI_RS07220 ^@ http://purl.uniprot.org/uniprot/Q0W492 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS06840 ^@ http://purl.uniprot.org/uniprot/Q0W409 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS03230 ^@ http://purl.uniprot.org/uniprot/Q0W1W0 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.|||Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/351160:RCI_RS04405 ^@ http://purl.uniprot.org/uniprot/Q0W2K6 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/351160:RCI_RS15615 ^@ http://purl.uniprot.org/uniprot/Q0W104 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS11500 ^@ http://purl.uniprot.org/uniprot/Q0W6V5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. CofH family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.|||The FO synthase complex consists of two subunits, CofG and CofH. http://togogenome.org/gene/351160:RCI_RS08960 ^@ http://purl.uniprot.org/uniprot/Q0W5C8 ^@ Similarity ^@ Belongs to the DNA glycosylase MPG family. http://togogenome.org/gene/351160:RCI_RS11230 ^@ http://purl.uniprot.org/uniprot/Q0W6P8 ^@ Similarity ^@ Belongs to the HupF/HypC family. http://togogenome.org/gene/351160:RCI_RS04305 ^@ http://purl.uniprot.org/uniprot/Q0W2I8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS00885 ^@ http://purl.uniprot.org/uniprot/Q0W0J7 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/351160:RCI_RS13870 ^@ http://purl.uniprot.org/uniprot/Q0W881 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the CdhC family.|||Binds 1 [Ni-Fe-S] cluster.|||Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).|||Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex). http://togogenome.org/gene/351160:RCI_RS05430 ^@ http://purl.uniprot.org/uniprot/Q0W363 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. http://togogenome.org/gene/351160:RCI_RS02490 ^@ http://purl.uniprot.org/uniprot/Q0W1F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS00865 ^@ http://purl.uniprot.org/uniprot/Q0W0J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS05940 ^@ http://purl.uniprot.org/uniprot/Q0W3H1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS06005 ^@ http://purl.uniprot.org/uniprot/Q0W3I4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS05290 ^@ http://purl.uniprot.org/uniprot/Q0W335 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrB family.|||Cell membrane|||Membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/351160:RCI_RS03975 ^@ http://purl.uniprot.org/uniprot/Q0W2B8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS00520 ^@ http://purl.uniprot.org/uniprot/Q0W0C4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS05190 ^@ http://purl.uniprot.org/uniprot/Q0W314 ^@ Function ^@ Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). http://togogenome.org/gene/351160:RCI_RS11090 ^@ http://purl.uniprot.org/uniprot/Q0W6L8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm|||Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.|||Heterodimer of two subunits, one of which binds GTP. http://togogenome.org/gene/351160:RCI_RS10265 ^@ http://purl.uniprot.org/uniprot/Q0W648 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homotetramer; dimer of dimers.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/351160:RCI_RS12220 ^@ http://purl.uniprot.org/uniprot/Q0W7A0 ^@ Similarity ^@ Belongs to the FPG family. http://togogenome.org/gene/351160:RCI_RS15320 ^@ http://purl.uniprot.org/uniprot/Q0W8Z1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/351160:RCI_RS14030 ^@ http://purl.uniprot.org/uniprot/Q0W8B1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS13060 ^@ http://purl.uniprot.org/uniprot/Q0W7S2 ^@ Similarity ^@ Belongs to the TlyA family. http://togogenome.org/gene/351160:RCI_RS10730 ^@ http://purl.uniprot.org/uniprot/Q0W6E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamine synthetase family.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS10625 ^@ http://purl.uniprot.org/uniprot/Q0W6C2 ^@ Similarity ^@ Belongs to the HisA/HisF family. http://togogenome.org/gene/351160:RCI_RS02530 ^@ http://purl.uniprot.org/uniprot/Q0W1G3 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. http://togogenome.org/gene/351160:RCI_RS09240 ^@ http://purl.uniprot.org/uniprot/Q0W5I4 ^@ Similarity ^@ Belongs to the HMG-CoA reductase family. http://togogenome.org/gene/351160:RCI_RS05690 ^@ http://purl.uniprot.org/uniprot/Q0W3B6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the diaminopimelate epimerase family.|||Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/351160:RCI_RS09195 ^@ http://purl.uniprot.org/uniprot/Q0W5H5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/351160:RCI_RS03235 ^@ http://purl.uniprot.org/uniprot/Q0W1W1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 2 subfamily.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS11810 ^@ http://purl.uniprot.org/uniprot/Q0W719 ^@ Function|||Similarity ^@ Belongs to the archaeal 6-HMPDK family.|||Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP). http://togogenome.org/gene/351160:RCI_RS12145 ^@ http://purl.uniprot.org/uniprot/Q0W788 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/351160:RCI_RS05785 ^@ http://purl.uniprot.org/uniprot/Q0W3D9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS03895 ^@ http://purl.uniprot.org/uniprot/Q0W2A2 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/351160:RCI_RS01105 ^@ http://purl.uniprot.org/uniprot/Q0W0N9 ^@ Function|||Similarity ^@ Belongs to the adenylate cyclase family. DacZ subfamily.|||Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. http://togogenome.org/gene/351160:RCI_RS10195 ^@ http://purl.uniprot.org/uniprot/Q0W634 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS12695 ^@ http://purl.uniprot.org/uniprot/Q0W7J8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Mediates influx of magnesium ions.|||Membrane http://togogenome.org/gene/351160:RCI_RS01575 ^@ http://purl.uniprot.org/uniprot/Q0W0Y4 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family.|||Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). http://togogenome.org/gene/351160:RCI_RS05040 ^@ http://purl.uniprot.org/uniprot/Q0W2Y4 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/351160:RCI_RS04615 ^@ http://purl.uniprot.org/uniprot/Q0W2P8 ^@ Function|||Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. http://togogenome.org/gene/351160:RCI_RS10175 ^@ http://purl.uniprot.org/uniprot/Q0W630 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/351160:RCI_RS02805 ^@ http://purl.uniprot.org/uniprot/Q0W1M2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.|||Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.|||Homodecamer. http://togogenome.org/gene/351160:RCI_RS13380 ^@ http://purl.uniprot.org/uniprot/Q0W7Y6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS14860 ^@ http://purl.uniprot.org/uniprot/Q0W8S0 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/351160:RCI_RS14840 ^@ http://purl.uniprot.org/uniprot/Q0W8R6 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/351160:RCI_RS13955 ^@ http://purl.uniprot.org/uniprot/Q0W896 ^@ Function|||Similarity|||Subunit ^@ Belongs to the threonine synthase family. Cysteate synthase subfamily.|||Homotrimer.|||Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate. http://togogenome.org/gene/351160:RCI_RS04350 ^@ http://purl.uniprot.org/uniprot/Q0W2J5 ^@ Similarity ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. http://togogenome.org/gene/351160:RCI_RS03205 ^@ http://purl.uniprot.org/uniprot/Q0W1V6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/351160:RCI_RS11280 ^@ http://purl.uniprot.org/uniprot/Q0W6Q8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/351160:RCI_RS12420 ^@ http://purl.uniprot.org/uniprot/Q0W7E4 ^@ Function ^@ Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. http://togogenome.org/gene/351160:RCI_RS10595 ^@ http://purl.uniprot.org/uniprot/Q0W6B5 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/351160:RCI_RS14825 ^@ http://purl.uniprot.org/uniprot/Q0W8R3 ^@ Similarity ^@ Belongs to the UPF0107 family. http://togogenome.org/gene/351160:RCI_RS02195 ^@ http://purl.uniprot.org/uniprot/Q0W1A0 ^@ Similarity ^@ Belongs to the Nth/MutY family. http://togogenome.org/gene/351160:RCI_RS14185 ^@ http://purl.uniprot.org/uniprot/Q0W8E0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrK family.|||Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit.|||Heterotetramer of 2 PyrK and 2 PyrD type B subunits.|||Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). http://togogenome.org/gene/351160:RCI_RS10615 ^@ http://purl.uniprot.org/uniprot/Q0W6B9 ^@ Function|||Similarity ^@ Belongs to the MfnB family.|||Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). http://togogenome.org/gene/351160:RCI_RS14600 ^@ http://purl.uniprot.org/uniprot/Q0W8M0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase small subunit family.|||Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL). http://togogenome.org/gene/351160:RCI_RS15120 ^@ http://purl.uniprot.org/uniprot/Q0W944 ^@ Similarity ^@ Belongs to the UPF0288 family. http://togogenome.org/gene/351160:RCI_RS04205 ^@ http://purl.uniprot.org/uniprot/Q0W2G7 ^@ Function|||Similarity ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. http://togogenome.org/gene/351160:RCI_RS09055 ^@ http://purl.uniprot.org/uniprot/Q0W5E8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6B family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/351160:RCI_RS03340 ^@ http://purl.uniprot.org/uniprot/Q0W1Y2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/351160:RCI_RS01660 ^@ http://purl.uniprot.org/uniprot/Q0W0Z8 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/351160:RCI_RS10410 ^@ http://purl.uniprot.org/uniprot/Q0W675 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/351160:RCI_RS11055 ^@ http://purl.uniprot.org/uniprot/Q0W6L1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. Hel308 subfamily.|||DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.|||Monomer. http://togogenome.org/gene/351160:RCI_RS01530 ^@ http://purl.uniprot.org/uniprot/Q0W0X4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/351160:RCI_RS10165 ^@ http://purl.uniprot.org/uniprot/Q0W628 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/351160:RCI_RS07085 ^@ http://purl.uniprot.org/uniprot/Q0W461 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS00370 ^@ http://purl.uniprot.org/uniprot/Q0W095 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Bcr/CmlA family. http://togogenome.org/gene/351160:RCI_RS05300 ^@ http://purl.uniprot.org/uniprot/Q0W337 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrD family.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/351160:RCI_RS08795 ^@ http://purl.uniprot.org/uniprot/Q0W595 ^@ Similarity ^@ Belongs to the carbamoyltransferase HypF family. http://togogenome.org/gene/351160:RCI_RS06360 ^@ http://purl.uniprot.org/uniprot/Q0W3Q7 ^@ Similarity ^@ Belongs to the transcriptional regulator TrmB family. http://togogenome.org/gene/351160:RCI_RS11815 ^@ http://purl.uniprot.org/uniprot/Q0W720 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/351160:RCI_RS09160 ^@ http://purl.uniprot.org/uniprot/Q0W5G9 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/351160:RCI_RS03260 ^@ http://purl.uniprot.org/uniprot/Q0W1W6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/351160:RCI_RS00935 ^@ http://purl.uniprot.org/uniprot/Q0W0K8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS04265 ^@ http://purl.uniprot.org/uniprot/Q0W2I0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS06010 ^@ http://purl.uniprot.org/uniprot/Q0W3I5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS10795 ^@ http://purl.uniprot.org/uniprot/Q0W6F6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DHBP synthase family.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Homodimer. http://togogenome.org/gene/351160:RCI_RS00990 ^@ http://purl.uniprot.org/uniprot/Q0W0L7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS09465 ^@ http://purl.uniprot.org/uniprot/Q0W5N3 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/351160:RCI_RS10805 ^@ http://purl.uniprot.org/uniprot/Q0W6F9 ^@ Similarity ^@ Belongs to the ComB family. http://togogenome.org/gene/351160:RCI_RS07660 ^@ http://purl.uniprot.org/uniprot/Q0W4J0 ^@ Similarity ^@ In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/351160:RCI_RS12660 ^@ http://purl.uniprot.org/uniprot/Q0W7J1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS08495 ^@ http://purl.uniprot.org/uniprot/Q0W517 ^@ Cofactor|||Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/351160:RCI_RS15235 ^@ http://purl.uniprot.org/uniprot/Q0W8X4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6B family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/351160:RCI_RS02480 ^@ http://purl.uniprot.org/uniprot/Q0W7U5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/351160:RCI_RS15015 ^@ http://purl.uniprot.org/uniprot/Q0W8U9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCH family.|||Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS09810 ^@ http://purl.uniprot.org/uniprot/Q0W5V4 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MobA family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.|||Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. http://togogenome.org/gene/351160:RCI_RS00595 ^@ http://purl.uniprot.org/uniprot/Q0W0E0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the CofD family.|||Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS08040 ^@ http://purl.uniprot.org/uniprot/Q0W4S0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS11395 ^@ http://purl.uniprot.org/uniprot/Q0W6T3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS05070 ^@ http://purl.uniprot.org/uniprot/Q0W2Z0 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/351160:RCI_RS05030 ^@ http://purl.uniprot.org/uniprot/Q0W2Y2 ^@ Similarity ^@ Belongs to the UPF0440 family. http://togogenome.org/gene/351160:RCI_RS13055 ^@ http://purl.uniprot.org/uniprot/Q0W7S1 ^@ Similarity ^@ Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. http://togogenome.org/gene/351160:RCI_RS07885 ^@ http://purl.uniprot.org/uniprot/Q0W4N8 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS14975 ^@ http://purl.uniprot.org/uniprot/Q0W8U2 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/351160:RCI_RS05095 ^@ http://purl.uniprot.org/uniprot/Q0W2Z5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/351160:RCI_RS05700 ^@ http://purl.uniprot.org/uniprot/Q0W3B8 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/351160:RCI_RS02510 ^@ http://purl.uniprot.org/uniprot/Q0W1F9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.|||Cytoplasm|||Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. http://togogenome.org/gene/351160:RCI_RS05725 ^@ http://purl.uniprot.org/uniprot/Q0W3C5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS03675 ^@ http://purl.uniprot.org/uniprot/Q0W253 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. http://togogenome.org/gene/351160:RCI_RS11975 ^@ http://purl.uniprot.org/uniprot/Q0W752 ^@ Similarity ^@ Belongs to the archaeal-type GPI family. http://togogenome.org/gene/351160:RCI_RS13555 ^@ http://purl.uniprot.org/uniprot/Q0W822 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/351160:RCI_RS08995 ^@ http://purl.uniprot.org/uniprot/Q0W5D4 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. http://togogenome.org/gene/351160:RCI_RS02175 ^@ http://purl.uniprot.org/uniprot/Q0W196 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/351160:RCI_RS06370 ^@ http://purl.uniprot.org/uniprot/Q0W3Q9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS03965 ^@ http://purl.uniprot.org/uniprot/Q0W2B6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS03935 ^@ http://purl.uniprot.org/uniprot/Q0W2B0 ^@ Similarity ^@ Belongs to the beta-class carbonic anhydrase family. http://togogenome.org/gene/351160:RCI_RS05280 ^@ http://purl.uniprot.org/uniprot/Q0W333 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrA family.|||Binds 1 5-hydroxybenzimidazolylcobamide group.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/351160:RCI_RS02655 ^@ http://purl.uniprot.org/uniprot/Q0W1J0 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruD family.|||Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs. http://togogenome.org/gene/351160:RCI_RS07650 ^@ http://purl.uniprot.org/uniprot/Q0W4I8 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. http://togogenome.org/gene/351160:RCI_RS09595 ^@ http://purl.uniprot.org/uniprot/Q0W5Q9 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS04475 ^@ http://purl.uniprot.org/uniprot/Q0W2M0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/351160:RCI_RS01765 ^@ http://purl.uniprot.org/uniprot/Q0W115 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/351160:RCI_RS12495 ^@ http://purl.uniprot.org/uniprot/Q0W7G0 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.|||Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS00290 ^@ http://purl.uniprot.org/uniprot/Q0W081 ^@ Similarity ^@ Belongs to the UPF0212 family. http://togogenome.org/gene/351160:RCI_RS15240 ^@ http://purl.uniprot.org/uniprot/Q0W8X5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6A family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/351160:RCI_RS14485 ^@ http://purl.uniprot.org/uniprot/Q0W8J6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS03370 ^@ http://purl.uniprot.org/uniprot/Q0W1Y8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/351160:RCI_RS04865 ^@ http://purl.uniprot.org/uniprot/Q0W2V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS01215 ^@ http://purl.uniprot.org/uniprot/Q0W0R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/351160:RCI_RS14160 ^@ http://purl.uniprot.org/uniprot/Q0W8D5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.|||Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.|||Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/351160:RCI_RS11285 ^@ http://purl.uniprot.org/uniprot/Q0W6Q9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Monomer. http://togogenome.org/gene/351160:RCI_RS14585 ^@ http://purl.uniprot.org/uniprot/Q0W8L6 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/351160:RCI_RS12120 ^@ http://purl.uniprot.org/uniprot/Q0W782 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/351160:RCI_RS12990 ^@ http://purl.uniprot.org/uniprot/Q0W7Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS09190 ^@ http://purl.uniprot.org/uniprot/Q0W5H4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/351160:RCI_RS01345 ^@ http://purl.uniprot.org/uniprot/Q0W0T5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endonuclease V family.|||Cytoplasm|||DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. http://togogenome.org/gene/351160:RCI_RS04585 ^@ http://purl.uniprot.org/uniprot/Q0W2P2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. BUD32 family. http://togogenome.org/gene/351160:RCI_RS10170 ^@ http://purl.uniprot.org/uniprot/Q0W629 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/351160:RCI_RS14335 ^@ http://purl.uniprot.org/uniprot/Q0W8G9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds at least 2 Zn(2+) per subunit.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/351160:RCI_RS06160 ^@ http://purl.uniprot.org/uniprot/Q0W3L6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS06670 ^@ http://purl.uniprot.org/uniprot/Q0W3X1 ^@ Similarity ^@ Belongs to the peptidase S33 family. http://togogenome.org/gene/351160:RCI_RS15220 ^@ http://purl.uniprot.org/uniprot/Q0W8X1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||Cytoplasm|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/351160:RCI_RS13865 ^@ http://purl.uniprot.org/uniprot/Q0W880 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CdhD family.|||Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).|||Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex. http://togogenome.org/gene/351160:RCI_RS03985 ^@ http://purl.uniprot.org/uniprot/Q0W2C0 ^@ Similarity ^@ Belongs to the FrhG family. http://togogenome.org/gene/351160:RCI_RS15210 ^@ http://purl.uniprot.org/uniprot/Q0W8X0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/351160:RCI_RS10275 ^@ http://purl.uniprot.org/uniprot/Q0W650 ^@ Similarity ^@ Belongs to the DeoC/FbaB aldolase family. http://togogenome.org/gene/351160:RCI_RS04125 ^@ http://purl.uniprot.org/uniprot/Q0W2F0 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase Pus10 family.|||Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/351160:RCI_RS12925 ^@ http://purl.uniprot.org/uniprot/Q0W7P5 ^@ Function ^@ Protects DNA against thermal denaturation and modulates transcription. http://togogenome.org/gene/351160:RCI_RS01405 ^@ http://purl.uniprot.org/uniprot/Q0W0U7 ^@ Similarity ^@ Belongs to the HdrB family. http://togogenome.org/gene/351160:RCI_RS01210 ^@ http://purl.uniprot.org/uniprot/Q0W0R0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS04545 ^@ http://purl.uniprot.org/uniprot/Q0W2N4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS15225 ^@ http://purl.uniprot.org/uniprot/Q0W8X2 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. http://togogenome.org/gene/351160:RCI_RS13450 ^@ http://purl.uniprot.org/uniprot/Q0W801 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS07055 ^@ http://purl.uniprot.org/uniprot/Q0W454 ^@ Cofactor|||Similarity ^@ Belongs to the desulfoferrodoxin family.|||Binds 1 Fe(2+) ion per subunit. The iron ion 2 is coordinated via four histidines and one cysteine residue.|||Binds 1 Fe(3+) ion per subunit. The iron ion 1 is coordinated via 4 cysteine residues. http://togogenome.org/gene/351160:RCI_RS00120 ^@ http://purl.uniprot.org/uniprot/Q0W049 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/351160:RCI_RS11335 ^@ http://purl.uniprot.org/uniprot/Q0W6S1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS09770 ^@ http://purl.uniprot.org/uniprot/Q0W5U6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal DNA polymerase II family.|||Heterodimer of a large subunit and a small subunit.|||Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity). http://togogenome.org/gene/351160:RCI_RS10465 ^@ http://purl.uniprot.org/uniprot/Q0W684 ^@ Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Homodimer. http://togogenome.org/gene/351160:RCI_RS00110 ^@ http://purl.uniprot.org/uniprot/Q0W047 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.|||Membrane http://togogenome.org/gene/351160:RCI_RS13460 ^@ http://purl.uniprot.org/uniprot/Q0W803 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/351160:RCI_RS03010 ^@ http://purl.uniprot.org/uniprot/Q0W1R8 ^@ Similarity ^@ Belongs to the RuvC family. http://togogenome.org/gene/351160:RCI_RS03995 ^@ http://purl.uniprot.org/uniprot/Q0W2C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNT transporter (TC 2.A.44) family.|||Membrane http://togogenome.org/gene/351160:RCI_RS14325 ^@ http://purl.uniprot.org/uniprot/Q0W8G7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/351160:RCI_RS14210 ^@ http://purl.uniprot.org/uniprot/Q0W8E5 ^@ Similarity ^@ Belongs to the NOP5/NOP56 family. http://togogenome.org/gene/351160:RCI_RS03685 ^@ http://purl.uniprot.org/uniprot/Q0W255 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/351160:RCI_RS01370 ^@ http://purl.uniprot.org/uniprot/Q0W0U0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/351160:RCI_RS04385 ^@ http://purl.uniprot.org/uniprot/Q0W2K2 ^@ Similarity ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/351160:RCI_RS15945 ^@ http://purl.uniprot.org/uniprot/Q0W7B6 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/351160:RCI_RS01760 ^@ http://purl.uniprot.org/uniprot/Q0W114 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/351160:RCI_RS02785 ^@ http://purl.uniprot.org/uniprot/Q0W1L8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the thiamine-phosphate synthase family.|||Binds 1 Mg(2+) ion per subunit.|||Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). http://togogenome.org/gene/351160:RCI_RS09440 ^@ http://purl.uniprot.org/uniprot/Q0W5M8 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family.|||Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. http://togogenome.org/gene/351160:RCI_RS11480 ^@ http://purl.uniprot.org/uniprot/Q0W6V1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CofC family.|||Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.|||Homodimer. http://togogenome.org/gene/351160:RCI_RS03970 ^@ http://purl.uniprot.org/uniprot/Q0W2B7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS05080 ^@ http://purl.uniprot.org/uniprot/Q0W2Z2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/351160:RCI_RS08080 ^@ http://purl.uniprot.org/uniprot/Q0W4S8 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/351160:RCI_RS14115 ^@ http://purl.uniprot.org/uniprot/Q0W8C7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/351160:RCI_RS11095 ^@ http://purl.uniprot.org/uniprot/Q0W6M0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.|||Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.|||Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/351160:RCI_RS02940 ^@ http://purl.uniprot.org/uniprot/Q0W1Q4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/351160:RCI_RS10395 ^@ http://purl.uniprot.org/uniprot/Q0W672 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/351160:RCI_RS08165 ^@ http://purl.uniprot.org/uniprot/Q0W4U7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecF subfamily.|||Cell membrane|||Involved in protein export.|||Membrane|||Part of the protein translocation apparatus. Forms a complex with SecD. http://togogenome.org/gene/351160:RCI_RS10070 ^@ http://purl.uniprot.org/uniprot/Q0W607 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS04515 ^@ http://purl.uniprot.org/uniprot/Q0W2M8 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/351160:RCI_RS12040 ^@ http://purl.uniprot.org/uniprot/Q0W766 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.|||Cell membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. http://togogenome.org/gene/351160:RCI_RS11365 ^@ http://purl.uniprot.org/uniprot/Q0W6S7 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/351160:RCI_RS07655 ^@ http://purl.uniprot.org/uniprot/Q0W4I9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/351160:RCI_RS01465 ^@ http://purl.uniprot.org/uniprot/Q0W0W0 ^@ Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. http://togogenome.org/gene/351160:RCI_RS08550 ^@ http://purl.uniprot.org/uniprot/Q0W529 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS12170 ^@ http://purl.uniprot.org/uniprot/Q0W793 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the archaeal DnaG primase family.|||Binds two Mg(2+) per subunit.|||Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome. http://togogenome.org/gene/351160:RCI_RS00875 ^@ http://purl.uniprot.org/uniprot/Q0W0J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the auxin efflux carrier (TC 2.A.69) family.|||Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS14380 ^@ http://purl.uniprot.org/uniprot/Q0W8H6 ^@ Caution|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS03680 ^@ http://purl.uniprot.org/uniprot/Q0W254 ^@ Caution|||Function|||Similarity ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS10155 ^@ http://purl.uniprot.org/uniprot/Q0W626 ^@ Similarity ^@ Belongs to the anthranilate synthase component I family. http://togogenome.org/gene/351160:RCI_RS01400 ^@ http://purl.uniprot.org/uniprot/Q0W0U6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HdrA family.|||Cytoplasm|||Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).|||The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC. http://togogenome.org/gene/351160:RCI_RS09900 ^@ http://purl.uniprot.org/uniprot/Q0W5X2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS07980 ^@ http://purl.uniprot.org/uniprot/Q0W4R0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DtxR/MntR family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/351160:RCI_RS12370 ^@ http://purl.uniprot.org/uniprot/Q0W7D4 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/351160:RCI_RS14830 ^@ http://purl.uniprot.org/uniprot/Q0W8R4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS06440 ^@ http://purl.uniprot.org/uniprot/Q0W3S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BioY family.|||Cell membrane http://togogenome.org/gene/351160:RCI_RS11435 ^@ http://purl.uniprot.org/uniprot/Q0W6U1 ^@ Similarity ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. http://togogenome.org/gene/351160:RCI_RS03335 ^@ http://purl.uniprot.org/uniprot/Q0W1Y1 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/351160:RCI_RS06835 ^@ http://purl.uniprot.org/uniprot/Q0W408 ^@ Function|||Similarity ^@ Belongs to the glutaredoxin family.|||Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro. http://togogenome.org/gene/351160:RCI_RS01330 ^@ http://purl.uniprot.org/uniprot/Q0W0T2 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.|||Cell membrane|||Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Membrane|||Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function. http://togogenome.org/gene/351160:RCI_RS04115 ^@ http://purl.uniprot.org/uniprot/Q0W2E8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.|||Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure. http://togogenome.org/gene/351160:RCI_RS14190 ^@ http://purl.uniprot.org/uniprot/Q0W8E1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.|||Cytoplasm|||Heterotetramer of 2 PyrK and 2 PyrD type B subunits. http://togogenome.org/gene/351160:RCI_RS10220 ^@ http://purl.uniprot.org/uniprot/Q0W639 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS01960 ^@ http://purl.uniprot.org/uniprot/Q0W154 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS08215 ^@ http://purl.uniprot.org/uniprot/Q0W4V7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS03265 ^@ http://purl.uniprot.org/uniprot/Q0W1W7 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/351160:RCI_RS11220 ^@ http://purl.uniprot.org/uniprot/Q0W6P6 ^@ Caution|||Function|||Similarity ^@ Belongs to the Nre family.|||Involved in DNA damage repair.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS06530 ^@ http://purl.uniprot.org/uniprot/Q0W3U4 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/351160:RCI_RS07065 ^@ http://purl.uniprot.org/uniprot/Q0W456 ^@ Caution|||Function|||Similarity ^@ Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.|||Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS11240 ^@ http://purl.uniprot.org/uniprot/Q0W6Q0 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/351160:RCI_RS00125 ^@ http://purl.uniprot.org/uniprot/Q0W050 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. Probably involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA. http://togogenome.org/gene/351160:RCI_RS02225 ^@ http://purl.uniprot.org/uniprot/Q0W1A6 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/351160:RCI_RS13585 ^@ http://purl.uniprot.org/uniprot/Q0W827 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS03270 ^@ http://purl.uniprot.org/uniprot/Q0W1W8 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Part of the 30S ribosomal subunit. Contacts protein S4.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/351160:RCI_RS07875 ^@ http://purl.uniprot.org/uniprot/Q0W4N6 ^@ Function|||Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family.|||Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. http://togogenome.org/gene/351160:RCI_RS06495 ^@ http://purl.uniprot.org/uniprot/Q0W3T6 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS05455 ^@ http://purl.uniprot.org/uniprot/Q0W368 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Membrane http://togogenome.org/gene/351160:RCI_RS05420 ^@ http://purl.uniprot.org/uniprot/Q0W361 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/351160:RCI_RS06170 ^@ http://purl.uniprot.org/uniprot/Q0W3L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS03390 ^@ http://purl.uniprot.org/uniprot/Q0W1Z4 ^@ Similarity ^@ Belongs to the Nth/MutY family. http://togogenome.org/gene/351160:RCI_RS07295 ^@ http://purl.uniprot.org/uniprot/Q0W4A8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal dihydroneopterin aldolase family.|||Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).|||Homotetramer. http://togogenome.org/gene/351160:RCI_RS00310 ^@ http://purl.uniprot.org/uniprot/Q0W085 ^@ Function|||Similarity|||Subunit ^@ Belongs to the diphthine synthase family.|||Homodimer.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/351160:RCI_RS14385 ^@ http://purl.uniprot.org/uniprot/Q0W8H7 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/351160:RCI_RS10550 ^@ http://purl.uniprot.org/uniprot/Q0W6A5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS07010 ^@ http://purl.uniprot.org/uniprot/Q0W443 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the NifH/BchL/ChlL family.|||Binds 1 [4Fe-4S] cluster per dimer.|||Homodimer.|||The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.|||The reversible ADP-ribosylation of Arg-97 inactivates the nitrogenase reductase and regulates nitrogenase activity. http://togogenome.org/gene/351160:RCI_RS00065 ^@ http://purl.uniprot.org/uniprot/Q0W037 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcS subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/351160:RCI_RS03255 ^@ http://purl.uniprot.org/uniprot/Q0W1W5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/351160:RCI_RS05510 ^@ http://purl.uniprot.org/uniprot/Q0W379 ^@ Similarity ^@ Belongs to the FldB/FldC dehydratase alpha/beta subunit family. http://togogenome.org/gene/351160:RCI_RS10000 ^@ http://purl.uniprot.org/uniprot/Q0W5Z3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/351160:RCI_RS07855 ^@ http://purl.uniprot.org/uniprot/Q0W4N3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the quinolinate synthase family. Type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.|||Cytoplasm http://togogenome.org/gene/351160:RCI_RS04370 ^@ http://purl.uniprot.org/uniprot/Q0W2J9 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/351160:RCI_RS15040 ^@ http://purl.uniprot.org/uniprot/Q0W8V4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS09360 ^@ http://purl.uniprot.org/uniprot/Q0W5K9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/351160:RCI_RS14645 ^@ http://purl.uniprot.org/uniprot/Q0W8N0 ^@ Similarity ^@ Belongs to the pyruvate kinase family.|||In the C-terminal section; belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/351160:RCI_RS05695 ^@ http://purl.uniprot.org/uniprot/Q0W3B7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.|||Homodimer.|||Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. http://togogenome.org/gene/351160:RCI_RS05345 ^@ http://purl.uniprot.org/uniprot/Q0W346 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/351160:RCI_RS14105 ^@ http://purl.uniprot.org/uniprot/Q0W8C5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/351160:RCI_RS07235 ^@ http://purl.uniprot.org/uniprot/Q0W496 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.|||Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/351160:RCI_RS15510 ^@ http://purl.uniprot.org/uniprot/Q0W930 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.|||Cytoplasm|||Heterotetramer of two alpha and two beta chains.|||Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway. http://togogenome.org/gene/351160:RCI_RS13975 ^@ http://purl.uniprot.org/uniprot/Q0W8A0 ^@ Similarity ^@ Belongs to the UPF0179 family. http://togogenome.org/gene/351160:RCI_RS14475 ^@ http://purl.uniprot.org/uniprot/Q0W8J4 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/351160:RCI_RS10850 ^@ http://purl.uniprot.org/uniprot/Q0W6G8 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. PoK subfamily.|||Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway. http://togogenome.org/gene/351160:RCI_RS04535 ^@ http://purl.uniprot.org/uniprot/Q0W2N2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/351160:RCI_RS10835 ^@ http://purl.uniprot.org/uniprot/Q0W6G5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Spt4 family.|||Heterodimer composed of Spt4 and Spt5.|||Stimulates transcription elongation. http://togogenome.org/gene/351160:RCI_RS03190 ^@ http://purl.uniprot.org/uniprot/Q0W1V3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.|||Binds 1 [3Fe-4S] cluster.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/351160:RCI_RS08740 ^@ http://purl.uniprot.org/uniprot/Q0W582 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/351160:RCI_RS11170 ^@ http://purl.uniprot.org/uniprot/Q0W6N4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M32 family.|||Binds 1 zinc ion per subunit.|||Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. http://togogenome.org/gene/351160:RCI_RS12665 ^@ http://purl.uniprot.org/uniprot/Q0W7J2 ^@ Function ^@ Part of a potassium transport system. http://togogenome.org/gene/351160:RCI_RS02485 ^@ http://purl.uniprot.org/uniprot/Q0W1F4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/351160:RCI_RS06135 ^@ http://purl.uniprot.org/uniprot/Q0W3L1 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/351160:RCI_RS05085 ^@ http://purl.uniprot.org/uniprot/Q0W2Z3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 3 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/351160:RCI_RS01550 ^@ http://purl.uniprot.org/uniprot/Q0W0X9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/351160:RCI_RS14255 ^@ http://purl.uniprot.org/uniprot/Q0W8F4 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/351160:RCI_RS05025 ^@ http://purl.uniprot.org/uniprot/Q0W2Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0014 family.|||Membrane http://togogenome.org/gene/351160:RCI_RS08200 ^@ http://purl.uniprot.org/uniprot/Q0W4V4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS00165 ^@ http://purl.uniprot.org/uniprot/Q0W058 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/351160:RCI_RS06610 ^@ http://purl.uniprot.org/uniprot/Q0W3V9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS10770 ^@ http://purl.uniprot.org/uniprot/Q0W6F1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS09125 ^@ http://purl.uniprot.org/uniprot/Q0W5G2 ^@ Similarity ^@ Belongs to the UPF0147 family. http://togogenome.org/gene/351160:RCI_RS14495 ^@ http://purl.uniprot.org/uniprot/Q0W8J8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/351160:RCI_RS11235 ^@ http://purl.uniprot.org/uniprot/Q0W6P9 ^@ Function|||Similarity ^@ Belongs to the HypA/HybF family.|||Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. http://togogenome.org/gene/351160:RCI_RS08925 ^@ http://purl.uniprot.org/uniprot/Q0W5C1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/351160:RCI_RS09715 ^@ http://purl.uniprot.org/uniprot/Q0W5T5 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/351160:RCI_RS03795 ^@ http://purl.uniprot.org/uniprot/Q0W278 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/351160:RCI_RS11165 ^@ http://purl.uniprot.org/uniprot/Q0W6N3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/351160:RCI_RS14610 ^@ http://purl.uniprot.org/uniprot/Q0W8M2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/351160:RCI_RS04495 ^@ http://purl.uniprot.org/uniprot/Q0W2M4 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.