http://togogenome.org/gene/384616:PISL_RS06235 ^@ http://purl.uniprot.org/uniprot/A1RTU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA-PH family.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS08155 ^@ http://purl.uniprot.org/uniprot/A1RUV7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homotetramer; dimer of dimers.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/384616:PISL_RS08690 ^@ http://purl.uniprot.org/uniprot/A1RV63 ^@ Similarity ^@ Belongs to the RuvB family. http://togogenome.org/gene/384616:PISL_RS02330 ^@ http://purl.uniprot.org/uniprot/A1RRQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS05625 ^@ http://purl.uniprot.org/uniprot/A1RTI4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/384616:PISL_RS09240 ^@ http://purl.uniprot.org/uniprot/A1RVG7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSL4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. http://togogenome.org/gene/384616:PISL_RS09365 ^@ http://purl.uniprot.org/uniprot/A1RVJ1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dCTP deaminase family.|||Catalyzes the deamination of dCTP to dUTP.|||Homotrimer. http://togogenome.org/gene/384616:PISL_RS02725 ^@ http://purl.uniprot.org/uniprot/A1RRX6 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP. http://togogenome.org/gene/384616:PISL_RS09270 ^@ http://purl.uniprot.org/uniprot/A1RVH3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/384616:PISL_RS08790 ^@ http://purl.uniprot.org/uniprot/A1RV83 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.|||Specifically catalyzes the decarboxylation of L-arginine to agmatine. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity. http://togogenome.org/gene/384616:PISL_RS05415 ^@ http://purl.uniprot.org/uniprot/A1RTE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Belongs to the V-ATPase proteolipid subunit family.|||Membrane http://togogenome.org/gene/384616:PISL_RS03515 ^@ http://purl.uniprot.org/uniprot/A1RSC7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity). http://togogenome.org/gene/384616:PISL_RS02430 ^@ http://purl.uniprot.org/uniprot/A1RRS0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS08175 ^@ http://purl.uniprot.org/uniprot/A1RUW1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/384616:PISL_RS06865 ^@ http://purl.uniprot.org/uniprot/A1RU68 ^@ Caution|||Function|||Similarity ^@ Belongs to the Nre family.|||Involved in DNA damage repair.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/384616:PISL_RS00550 ^@ http://purl.uniprot.org/uniprot/A1RQQ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/384616:PISL_RS02275 ^@ http://purl.uniprot.org/uniprot/A1RRP0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/384616:PISL_RS06300 ^@ http://purl.uniprot.org/uniprot/A1RTV9 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/384616:PISL_RS09185 ^@ http://purl.uniprot.org/uniprot/A1RVF6 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type-I 3-dehydroquinase family.|||Homodimer.|||Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/384616:PISL_RS07395 ^@ http://purl.uniprot.org/uniprot/A1RUG8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TmcA family.|||Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||nucleolus http://togogenome.org/gene/384616:PISL_RS03505 ^@ http://purl.uniprot.org/uniprot/A1RSC5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.|||Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/384616:PISL_RS04135 ^@ http://purl.uniprot.org/uniprot/A1RSP7 ^@ Similarity ^@ Belongs to the UPF0173 family. http://togogenome.org/gene/384616:PISL_RS08125 ^@ http://purl.uniprot.org/uniprot/A1RUV1 ^@ Similarity ^@ Belongs to the SIS family. PHI subfamily. http://togogenome.org/gene/384616:PISL_RS00270 ^@ http://purl.uniprot.org/uniprot/A1RQK4 ^@ Function|||Similarity ^@ Belongs to the FAU-1 family.|||Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences. http://togogenome.org/gene/384616:PISL_RS09405 ^@ http://purl.uniprot.org/uniprot/A1RVJ9 ^@ Similarity ^@ Belongs to the DMRL synthase family. http://togogenome.org/gene/384616:PISL_RS06070 ^@ http://purl.uniprot.org/uniprot/A1RTR7 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the FBP aldolase/phosphatase family.|||Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).|||Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.|||Homooctamer; dimer of tetramers. http://togogenome.org/gene/384616:PISL_RS06705 ^@ http://purl.uniprot.org/uniprot/A1RU36 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/384616:PISL_RS00100 ^@ http://purl.uniprot.org/uniprot/A1RQH0 ^@ Function|||Similarity ^@ Belongs to the KptA/TPT1 family.|||Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase. http://togogenome.org/gene/384616:PISL_RS01670 ^@ http://purl.uniprot.org/uniprot/A1RRC0 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/384616:PISL_RS09890 ^@ http://purl.uniprot.org/uniprot/A1RVT4 ^@ Similarity ^@ Belongs to the UPF0248 family. http://togogenome.org/gene/384616:PISL_RS08035 ^@ http://purl.uniprot.org/uniprot/A1RUT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal NMN adenylyltransferase family.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS02455 ^@ http://purl.uniprot.org/uniprot/A1RRS5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL40 family. http://togogenome.org/gene/384616:PISL_RS02910 ^@ http://purl.uniprot.org/uniprot/A1RS12 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/384616:PISL_RS03405 ^@ http://purl.uniprot.org/uniprot/A1RSA5 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/384616:PISL_RS08475 ^@ http://purl.uniprot.org/uniprot/A1RV20 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/384616:PISL_RS02370 ^@ http://purl.uniprot.org/uniprot/A1RRQ8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/384616:PISL_RS03615 ^@ http://purl.uniprot.org/uniprot/A1RSE7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.|||Part of the RNA polymerase complex. http://togogenome.org/gene/384616:PISL_RS00525 ^@ http://purl.uniprot.org/uniprot/A1RQQ0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/384616:PISL_RS04295 ^@ http://purl.uniprot.org/uniprot/A1RSS8 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/384616:PISL_RS07730 ^@ http://purl.uniprot.org/uniprot/A1RUM9 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/384616:PISL_RS06240 ^@ http://purl.uniprot.org/uniprot/A1RTV0 ^@ Similarity ^@ Belongs to the histidinol dehydrogenase family. http://togogenome.org/gene/384616:PISL_RS09265 ^@ http://purl.uniprot.org/uniprot/A1RVH2 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/384616:PISL_RS05050 ^@ http://purl.uniprot.org/uniprot/A1RT72 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS03145 ^@ http://purl.uniprot.org/uniprot/A1RS55 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/384616:PISL_RS05575 ^@ http://purl.uniprot.org/uniprot/A1RTH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Membrane http://togogenome.org/gene/384616:PISL_RS09075 ^@ http://purl.uniprot.org/uniprot/A1RVD2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the shikimate dehydrogenase family.|||Homodimer.|||Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). http://togogenome.org/gene/384616:PISL_RS00850 ^@ http://purl.uniprot.org/uniprot/A1RQW6 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/384616:PISL_RS08745 ^@ http://purl.uniprot.org/uniprot/A1RV74 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/384616:PISL_RS04365 ^@ http://purl.uniprot.org/uniprot/A1RSU1 ^@ Similarity ^@ Belongs to the complex I subunit 3 family. http://togogenome.org/gene/384616:PISL_RS03915 ^@ http://purl.uniprot.org/uniprot/A1RSK3 ^@ Similarity ^@ Belongs to the UPF0210 family. http://togogenome.org/gene/384616:PISL_RS02755 ^@ http://purl.uniprot.org/uniprot/A1RRY2 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/384616:PISL_RS09555 ^@ http://purl.uniprot.org/uniprot/A1RVM6 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/384616:PISL_RS07380 ^@ http://purl.uniprot.org/uniprot/A1RUG4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/384616:PISL_RS00315 ^@ http://purl.uniprot.org/uniprot/A1RQL2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NadC/ModD family.|||Hexamer formed by 3 homodimers.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/384616:PISL_RS01330 ^@ http://purl.uniprot.org/uniprot/A1RR54 ^@ Similarity ^@ Belongs to the beta-class carbonic anhydrase family. http://togogenome.org/gene/384616:PISL_RS09225 ^@ http://purl.uniprot.org/uniprot/A1RVG4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/384616:PISL_RS02040 ^@ http://purl.uniprot.org/uniprot/A1RRJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 2 subfamily.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS05915 ^@ http://purl.uniprot.org/uniprot/A1RTP0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. Hel308 subfamily.|||DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.|||Monomer. http://togogenome.org/gene/384616:PISL_RS09900 ^@ http://purl.uniprot.org/uniprot/A1RVT6 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family. http://togogenome.org/gene/384616:PISL_RS09660 ^@ http://purl.uniprot.org/uniprot/A1RVP3 ^@ Similarity ^@ Belongs to the SfsA family. http://togogenome.org/gene/384616:PISL_RS01440 ^@ http://purl.uniprot.org/uniprot/A1RR74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. LysZ subfamily.|||Cytoplasm|||Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis). http://togogenome.org/gene/384616:PISL_RS06460 ^@ http://purl.uniprot.org/uniprot/A1RTY9 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. http://togogenome.org/gene/384616:PISL_RS03025 ^@ http://purl.uniprot.org/uniprot/A1RS34 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL24 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14. http://togogenome.org/gene/384616:PISL_RS01200 ^@ http://purl.uniprot.org/uniprot/A1RR30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/384616:PISL_RS05235 ^@ http://purl.uniprot.org/uniprot/A1RTA7 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/384616:PISL_RS05680 ^@ http://purl.uniprot.org/uniprot/A1RTJ3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/384616:PISL_RS06280 ^@ http://purl.uniprot.org/uniprot/A1RTV6 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/384616:PISL_RS05885 ^@ http://purl.uniprot.org/uniprot/A1RTN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic CoaD family.|||Cytoplasm|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/384616:PISL_RS05665 ^@ http://purl.uniprot.org/uniprot/A1RTJ0 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/384616:PISL_RS09885 ^@ http://purl.uniprot.org/uniprot/A1RVT3 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/384616:PISL_RS09100 ^@ http://purl.uniprot.org/uniprot/A1RVD8 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/384616:PISL_RS00280 ^@ http://purl.uniprot.org/uniprot/A1RQK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily.|||Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS03545 ^@ http://purl.uniprot.org/uniprot/A1RSD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endonuclease V family.|||Cytoplasm|||DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. http://togogenome.org/gene/384616:PISL_RS03630 ^@ http://purl.uniprot.org/uniprot/A1RSF0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/384616:PISL_RS08935 ^@ http://purl.uniprot.org/uniprot/A1RVB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NucS endonuclease family.|||Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS09785 ^@ http://purl.uniprot.org/uniprot/A1RVR4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS01110 ^@ http://purl.uniprot.org/uniprot/A1RR15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/384616:PISL_RS09305 ^@ http://purl.uniprot.org/uniprot/A1RVI0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/384616:PISL_RS03555 ^@ http://purl.uniprot.org/uniprot/A1RSD4 ^@ Similarity ^@ Belongs to the UPF0179 family. http://togogenome.org/gene/384616:PISL_RS04950 ^@ http://purl.uniprot.org/uniprot/A1RT52 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/384616:PISL_RS04575 ^@ http://purl.uniprot.org/uniprot/A1RSY3 ^@ Similarity ^@ Belongs to the flavin oxidoreductase frp family. http://togogenome.org/gene/384616:PISL_RS09125 ^@ http://purl.uniprot.org/uniprot/A1RVE2 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/384616:PISL_RS03675 ^@ http://purl.uniprot.org/uniprot/Q9UWR5 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family.|||Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. http://togogenome.org/gene/384616:PISL_RS02070 ^@ http://purl.uniprot.org/uniprot/A1RRK1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase Z family.|||Binds 2 Zn(2+) ions.|||Homodimer.|||Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. http://togogenome.org/gene/384616:PISL_RS08845 ^@ http://purl.uniprot.org/uniprot/A1RV93 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.|||Cell membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. http://togogenome.org/gene/384616:PISL_RS09590 ^@ http://purl.uniprot.org/uniprot/A1RVN3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/384616:PISL_RS01635 ^@ http://purl.uniprot.org/uniprot/A1RRB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS09230 ^@ http://purl.uniprot.org/uniprot/A1RVG5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29. http://togogenome.org/gene/384616:PISL_RS01780 ^@ http://purl.uniprot.org/uniprot/A1RRE2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. http://togogenome.org/gene/384616:PISL_RS00660 ^@ http://purl.uniprot.org/uniprot/A1RQS8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS04695 ^@ http://purl.uniprot.org/uniprot/A1RT04 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/384616:PISL_RS09725 ^@ http://purl.uniprot.org/uniprot/A1RVQ3 ^@ Function|||Similarity ^@ Belongs to the PEP-utilizing enzyme family.|||Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. http://togogenome.org/gene/384616:PISL_RS01285 ^@ http://purl.uniprot.org/uniprot/A1RR45 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. http://togogenome.org/gene/384616:PISL_RS08945 ^@ http://purl.uniprot.org/uniprot/A1RVB2 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/384616:PISL_RS05900 ^@ http://purl.uniprot.org/uniprot/A1RTN7 ^@ Caution|||Similarity ^@ Belongs to the acylphosphatase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/384616:PISL_RS01180 ^@ http://purl.uniprot.org/uniprot/A1RR27 ^@ Similarity ^@ Belongs to the Mg-chelatase subunit H family. http://togogenome.org/gene/384616:PISL_RS04955 ^@ http://purl.uniprot.org/uniprot/A1RT53 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/384616:PISL_RS08365 ^@ http://purl.uniprot.org/uniprot/A1RUZ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS08760 ^@ http://purl.uniprot.org/uniprot/A1RV77 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/384616:PISL_RS06650 ^@ http://purl.uniprot.org/uniprot/A1RU25 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/384616:PISL_RS05800 ^@ http://purl.uniprot.org/uniprot/A1RTL6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/384616:PISL_RS01900 ^@ http://purl.uniprot.org/uniprot/A1RRG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS06400 ^@ http://purl.uniprot.org/uniprot/A1RTX8 ^@ Caution|||Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.|||In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.|||In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.|||Monomer.|||This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures. http://togogenome.org/gene/384616:PISL_RS01305 ^@ http://purl.uniprot.org/uniprot/A1RR49 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/384616:PISL_RS09680 ^@ http://purl.uniprot.org/uniprot/A1RVP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/384616:PISL_RS03810 ^@ http://purl.uniprot.org/uniprot/A1RSI5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer. http://togogenome.org/gene/384616:PISL_RS01455 ^@ http://purl.uniprot.org/uniprot/A1RR78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS04860 ^@ http://purl.uniprot.org/uniprot/A1RT34 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the archaeal riboflavin kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN). http://togogenome.org/gene/384616:PISL_RS00750 ^@ http://purl.uniprot.org/uniprot/A1RQU5 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/384616:PISL_RS01065 ^@ http://purl.uniprot.org/uniprot/A1RR06 ^@ Similarity ^@ Belongs to the HupF/HypC family. http://togogenome.org/gene/384616:PISL_RS08655 ^@ http://purl.uniprot.org/uniprot/A1RV56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal adenylate kinase family.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS02365 ^@ http://purl.uniprot.org/uniprot/A1RRQ7 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/384616:PISL_RS09760 ^@ http://purl.uniprot.org/uniprot/A1RVR0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/384616:PISL_RS04690 ^@ http://purl.uniprot.org/uniprot/A1RT03 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/384616:PISL_RS04735 ^@ http://purl.uniprot.org/uniprot/A1RT12 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAC-alpha family.|||Contacts the emerging nascent chain on the ribosome.|||Homodimer. Interacts with the ribosome. Binds ribosomal RNA. http://togogenome.org/gene/384616:PISL_RS00405 ^@ http://purl.uniprot.org/uniprot/A1RQM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/384616:PISL_RS04435 ^@ http://purl.uniprot.org/uniprot/A1RSV5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6A family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/384616:PISL_RS04595 ^@ http://purl.uniprot.org/uniprot/A1RSY7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.|||Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.|||Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers. http://togogenome.org/gene/384616:PISL_RS07200 ^@ http://purl.uniprot.org/uniprot/A1RUD1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS06940 ^@ http://purl.uniprot.org/uniprot/A1RU82 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS04740 ^@ http://purl.uniprot.org/uniprot/A1RT13 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS04910 ^@ http://purl.uniprot.org/uniprot/A1RT44 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/384616:PISL_RS09565 ^@ http://purl.uniprot.org/uniprot/A1RVM8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DadA oxidoreductase family.|||Catalyzes the dehydrogenation of D-proline. Can also use other D-amino acids, but with lower efficiency.|||Cell membrane|||Homotetramer. http://togogenome.org/gene/384616:PISL_RS06110 ^@ http://purl.uniprot.org/uniprot/A1RTS5 ^@ Similarity ^@ Belongs to the MoaB/Mog family. http://togogenome.org/gene/384616:PISL_RS01675 ^@ http://purl.uniprot.org/uniprot/A1RRC1 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/384616:PISL_RS04035 ^@ http://purl.uniprot.org/uniprot/A1RSM7 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/384616:PISL_RS03080 ^@ http://purl.uniprot.org/uniprot/A1RS43 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/384616:PISL_RS06760 ^@ http://purl.uniprot.org/uniprot/A1RU47 ^@ Similarity ^@ Belongs to the disproportionating enzyme family. http://togogenome.org/gene/384616:PISL_RS01705 ^@ http://purl.uniprot.org/uniprot/A1RRC7 ^@ Similarity ^@ Belongs to the complex I 49 kDa subunit family. http://togogenome.org/gene/384616:PISL_RS03635 ^@ http://purl.uniprot.org/uniprot/A1RSF1 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. http://togogenome.org/gene/384616:PISL_RS08105 ^@ http://purl.uniprot.org/uniprot/A1RUU8 ^@ Caution|||Function|||Similarity ^@ Belongs to the UbiX/PAD1 family.|||Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/384616:PISL_RS04885 ^@ http://purl.uniprot.org/uniprot/A1RT39 ^@ Similarity ^@ Belongs to the Nth/MutY family. http://togogenome.org/gene/384616:PISL_RS09120 ^@ http://purl.uniprot.org/uniprot/A1RVE1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.|||Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).|||Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS01370 ^@ http://purl.uniprot.org/uniprot/A1RR60 ^@ Similarity ^@ Belongs to the 3-oxoacid CoA-transferase family. http://togogenome.org/gene/384616:PISL_RS07025 ^@ http://purl.uniprot.org/uniprot/A1RU98 ^@ Similarity ^@ Belongs to the UPF0284 family. http://togogenome.org/gene/384616:PISL_RS00530 ^@ http://purl.uniprot.org/uniprot/A1RQQ1 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/384616:PISL_RS04730 ^@ http://purl.uniprot.org/uniprot/A1RT11 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/384616:PISL_RS02375 ^@ http://purl.uniprot.org/uniprot/A1RRQ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Spt5 family.|||Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).|||Stimulates transcription elongation. http://togogenome.org/gene/384616:PISL_RS00535 ^@ http://purl.uniprot.org/uniprot/A1RQQ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/384616:PISL_RS02915 ^@ http://purl.uniprot.org/uniprot/A1RS13 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/384616:PISL_RS04985 ^@ http://purl.uniprot.org/uniprot/A1RT58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Membrane http://togogenome.org/gene/384616:PISL_RS05300 ^@ http://purl.uniprot.org/uniprot/A1RTC1 ^@ Similarity ^@ Belongs to the serine/threonine dehydratase family. http://togogenome.org/gene/384616:PISL_RS05580 ^@ http://purl.uniprot.org/uniprot/A1RTH4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/384616:PISL_RS08305 ^@ http://purl.uniprot.org/uniprot/A1RUY8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Forms a complex with TatA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/384616:PISL_RS02245 ^@ http://purl.uniprot.org/uniprot/A1RRN4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.|||Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. http://togogenome.org/gene/384616:PISL_RS08130 ^@ http://purl.uniprot.org/uniprot/A1RUV2 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.|||Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain. http://togogenome.org/gene/384616:PISL_RS04390 ^@ http://purl.uniprot.org/uniprot/A1RSU6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. http://togogenome.org/gene/384616:PISL_RS09675 ^@ http://purl.uniprot.org/uniprot/A1RVP5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC61-beta family.|||Cell membrane|||Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.|||Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex. http://togogenome.org/gene/384616:PISL_RS08375 ^@ http://purl.uniprot.org/uniprot/A1RV00 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS07405 ^@ http://purl.uniprot.org/uniprot/A1RUG9 ^@ Caution|||Function|||Similarity ^@ Belongs to the MqnA/MqnD family. MqnD subfamily.|||Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/384616:PISL_RS00740 ^@ http://purl.uniprot.org/uniprot/A1RQU3 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/384616:PISL_RS08480 ^@ http://purl.uniprot.org/uniprot/A1RV21 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS08680 ^@ http://purl.uniprot.org/uniprot/A1RV61 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/384616:PISL_RS01590 ^@ http://purl.uniprot.org/uniprot/A1RRA4 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72. http://togogenome.org/gene/384616:PISL_RS06225 ^@ http://purl.uniprot.org/uniprot/A1RTU7 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/384616:PISL_RS03575 ^@ http://purl.uniprot.org/uniprot/A1RSD8 ^@ Similarity ^@ Belongs to the snRNP Sm proteins family. http://togogenome.org/gene/384616:PISL_RS06990 ^@ http://purl.uniprot.org/uniprot/A1RU92 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/384616:PISL_RS03035 ^@ http://purl.uniprot.org/uniprot/A1RS36 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS05860 ^@ http://purl.uniprot.org/uniprot/A1RTM9 ^@ Similarity ^@ Belongs to the Nth/MutY family. http://togogenome.org/gene/384616:PISL_RS02215 ^@ http://purl.uniprot.org/uniprot/A1RRM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/384616:PISL_RS02195 ^@ http://purl.uniprot.org/uniprot/A1RRM4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/384616:PISL_RS07155 ^@ http://purl.uniprot.org/uniprot/A1RUC2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family. LysK subfamily.|||Binds 2 Zn(2+) or Co(2+) ions per subunit.|||Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS02395 ^@ http://purl.uniprot.org/uniprot/A1RRR3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/384616:PISL_RS03645 ^@ http://purl.uniprot.org/uniprot/A1RSF3 ^@ Similarity ^@ Belongs to the V-ATPase F subunit family. http://togogenome.org/gene/384616:PISL_RS07035 ^@ http://purl.uniprot.org/uniprot/A1RUA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Cell membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. http://togogenome.org/gene/384616:PISL_RS03885 ^@ http://purl.uniprot.org/uniprot/A1RSJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS01970 ^@ http://purl.uniprot.org/uniprot/A1RRI1 ^@ Similarity|||Subunit ^@ Belongs to the HTP reductase family.|||Homodimer. http://togogenome.org/gene/384616:PISL_RS02055 ^@ http://purl.uniprot.org/uniprot/A1RRJ8 ^@ Similarity ^@ Belongs to the NOP5/NOP56 family. http://togogenome.org/gene/384616:PISL_RS08460 ^@ http://purl.uniprot.org/uniprot/A1RV17 ^@ Similarity ^@ Belongs to the BlaI transcriptional regulatory family. http://togogenome.org/gene/384616:PISL_RS00115 ^@ http://purl.uniprot.org/uniprot/A1RQH3 ^@ Similarity ^@ Belongs to the UPF0282 family. http://togogenome.org/gene/384616:PISL_RS03650 ^@ http://purl.uniprot.org/uniprot/A1RSF4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-archaeol synthase family.|||Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.|||Cell membrane http://togogenome.org/gene/384616:PISL_RS09255 ^@ http://purl.uniprot.org/uniprot/A1RVH0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.|||Homodimer.|||Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. http://togogenome.org/gene/384616:PISL_RS01575 ^@ http://purl.uniprot.org/uniprot/A1RRA1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/384616:PISL_RS07080 ^@ http://purl.uniprot.org/uniprot/A1RUA9 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanD family.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.|||Cytoplasm|||Heterooctamer of four alpha and four beta subunits.|||Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus. http://togogenome.org/gene/384616:PISL_RS02700 ^@ http://purl.uniprot.org/uniprot/A1RRX1 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase class-2 family.|||Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. http://togogenome.org/gene/384616:PISL_RS03170 ^@ http://purl.uniprot.org/uniprot/A1RS60 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/384616:PISL_RS02660 ^@ http://purl.uniprot.org/uniprot/A1RRW3 ^@ Similarity ^@ Belongs to the UPF0273 family. http://togogenome.org/gene/384616:PISL_RS00180 ^@ http://purl.uniprot.org/uniprot/A1RQI6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/384616:PISL_RS04085 ^@ http://purl.uniprot.org/uniprot/A1RSN7 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ 2 residues (Tyr-67 and Arg-70) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.|||Belongs to the sirtuin family. Class III subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. http://togogenome.org/gene/384616:PISL_RS05410 ^@ http://purl.uniprot.org/uniprot/A1RTE1 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/384616:PISL_RS09320 ^@ http://purl.uniprot.org/uniprot/A1RVI3 ^@ Similarity|||Subunit ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Homohexamer. http://togogenome.org/gene/384616:PISL_RS03750 ^@ http://purl.uniprot.org/uniprot/A1RSH4 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/384616:PISL_RS09535 ^@ http://purl.uniprot.org/uniprot/A1RVM2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the QueC family.|||Binds 1 zinc ion per subunit.|||Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). http://togogenome.org/gene/384616:PISL_RS05690 ^@ http://purl.uniprot.org/uniprot/A1RTJ5 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/384616:PISL_RS06800 ^@ http://purl.uniprot.org/uniprot/A1RU55 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MqnC family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). http://togogenome.org/gene/384616:PISL_RS07755 ^@ http://purl.uniprot.org/uniprot/A1RUN3 ^@ Caution|||Function|||Similarity ^@ Belongs to the APS kinase family.|||Catalyzes the synthesis of activated sulfate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/384616:PISL_RS01700 ^@ http://purl.uniprot.org/uniprot/A1RRC6 ^@ Similarity ^@ Belongs to the complex I 20 kDa subunit family. http://togogenome.org/gene/384616:PISL_RS08955 ^@ http://purl.uniprot.org/uniprot/A1RVB4 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/384616:PISL_RS06625 ^@ http://purl.uniprot.org/uniprot/A1RU20 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/384616:PISL_RS02390 ^@ http://purl.uniprot.org/uniprot/A1RRR2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/384616:PISL_RS03700 ^@ http://purl.uniprot.org/uniprot/A1RSG4 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family. http://togogenome.org/gene/384616:PISL_RS02970 ^@ http://purl.uniprot.org/uniprot/A1RS24 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/384616:PISL_RS00640 ^@ http://purl.uniprot.org/uniprot/A1RQS3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).|||Cell membrane http://togogenome.org/gene/384616:PISL_RS06740 ^@ http://purl.uniprot.org/uniprot/A1RU43 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the spermidine/spermine synthase family.|||Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.|||Cytoplasm|||Homodimer or homotetramer. http://togogenome.org/gene/384616:PISL_RS07275 ^@ http://purl.uniprot.org/uniprot/A1RUE4 ^@ Subcellular Location Annotation ^@ Encapsulin nanocompartment http://togogenome.org/gene/384616:PISL_RS03895 ^@ http://purl.uniprot.org/uniprot/A1RSJ9 ^@ Similarity ^@ Belongs to the ETF alpha-subunit/FixB family. http://togogenome.org/gene/384616:PISL_RS09910 ^@ http://purl.uniprot.org/uniprot/A1RVT8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||Involved in both the arginine and lysine biosynthetic pathways. http://togogenome.org/gene/384616:PISL_RS06710 ^@ http://purl.uniprot.org/uniprot/A1RU37 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Part of the 30S ribosomal subunit. Contacts protein S4.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/384616:PISL_RS05875 ^@ http://purl.uniprot.org/uniprot/A1RTN2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M32 family.|||Binds 1 zinc ion per subunit.|||Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. http://togogenome.org/gene/384616:PISL_RS09130 ^@ http://purl.uniprot.org/uniprot/A1RVE3 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/384616:PISL_RS02020 ^@ http://purl.uniprot.org/uniprot/A1RRJ1 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/384616:PISL_RS02945 ^@ http://purl.uniprot.org/uniprot/A1RS19 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/384616:PISL_RS04200 ^@ http://purl.uniprot.org/uniprot/A1RSR0 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/384616:PISL_RS01610 ^@ http://purl.uniprot.org/uniprot/A1RRA8 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/384616:PISL_RS04965 ^@ http://purl.uniprot.org/uniprot/A1RT55 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/384616:PISL_RS05805 ^@ http://purl.uniprot.org/uniprot/A1RTL7 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.|||Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/384616:PISL_RS09770 ^@ http://purl.uniprot.org/uniprot/A1RVR1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS02555 ^@ http://purl.uniprot.org/uniprot/A1RRU4 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/384616:PISL_RS03445 ^@ http://purl.uniprot.org/uniprot/A1RSB3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. http://togogenome.org/gene/384616:PISL_RS09340 ^@ http://purl.uniprot.org/uniprot/A1RVI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/384616:PISL_RS02600 ^@ http://purl.uniprot.org/uniprot/A1RRV1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrI family.|||Binds 1 zinc ion per subunit.|||Contains catalytic and regulatory chains.|||Involved in allosteric regulation of aspartate carbamoyltransferase. http://togogenome.org/gene/384616:PISL_RS05375 ^@ http://purl.uniprot.org/uniprot/A1RTD5 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/384616:PISL_RS03040 ^@ http://purl.uniprot.org/uniprot/A1RS37 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS08565 ^@ http://purl.uniprot.org/uniprot/A1RV38 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcS subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/384616:PISL_RS05045 ^@ http://purl.uniprot.org/uniprot/A1RT71 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS09840 ^@ http://purl.uniprot.org/uniprot/A1RVS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/384616:PISL_RS07365 ^@ http://purl.uniprot.org/uniprot/A1RUG1 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/384616:PISL_RS03530 ^@ http://purl.uniprot.org/uniprot/A1RSD0 ^@ Function|||Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family.|||Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. http://togogenome.org/gene/384616:PISL_RS05700 ^@ http://purl.uniprot.org/uniprot/A1RTJ7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS05105 ^@ http://purl.uniprot.org/uniprot/A1RT81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/384616:PISL_RS07930 ^@ http://purl.uniprot.org/uniprot/A1RUR7 ^@ Similarity ^@ Belongs to the CRISPR-associated Csm3 family. http://togogenome.org/gene/384616:PISL_RS03385 ^@ http://purl.uniprot.org/uniprot/A1RSA1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/384616:PISL_RS03570 ^@ http://purl.uniprot.org/uniprot/A1RSD7 ^@ Function|||Similarity ^@ Belongs to the AdoMet synthase 2 family.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/384616:PISL_RS09520 ^@ http://purl.uniprot.org/uniprot/A1RVL9 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/384616:PISL_RS06815 ^@ http://purl.uniprot.org/uniprot/A1RU58 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/384616:PISL_RS02355 ^@ http://purl.uniprot.org/uniprot/A1RRQ5 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL20 family.|||Part of the 50S ribosomal subunit. Binds 23S rRNA. http://togogenome.org/gene/384616:PISL_RS00880 ^@ http://purl.uniprot.org/uniprot/A1RQX2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS06495 ^@ http://purl.uniprot.org/uniprot/A1RTZ6 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. http://togogenome.org/gene/384616:PISL_RS02715 ^@ http://purl.uniprot.org/uniprot/A1RRX4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/384616:PISL_RS07870 ^@ http://purl.uniprot.org/uniprot/A1RUQ5 ^@ Similarity ^@ Belongs to the HepT RNase toxin family. http://togogenome.org/gene/384616:PISL_RS05015 ^@ http://purl.uniprot.org/uniprot/A1RT65 ^@ Similarity ^@ Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/384616:PISL_RS03485 ^@ http://purl.uniprot.org/uniprot/A1RSC1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTH2 family.|||Cytoplasm|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/384616:PISL_RS05745 ^@ http://purl.uniprot.org/uniprot/A1RTK6 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/384616:PISL_RS02065 ^@ http://purl.uniprot.org/uniprot/A1RRK0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/384616:PISL_RS03140 ^@ http://purl.uniprot.org/uniprot/A1RS54 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/384616:PISL_RS02640 ^@ http://purl.uniprot.org/uniprot/A1RRV9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges. http://togogenome.org/gene/384616:PISL_RS07725 ^@ http://purl.uniprot.org/uniprot/A1RUM8 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. http://togogenome.org/gene/384616:PISL_RS00055 ^@ http://purl.uniprot.org/uniprot/A1RQG1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS10290 ^@ http://purl.uniprot.org/uniprot/A1RW13 ^@ Function|||Similarity|||Subunit ^@ Belongs to the THI4 family.|||Homooctamer; tetramer of dimers.|||Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. http://togogenome.org/gene/384616:PISL_RS06745 ^@ http://purl.uniprot.org/uniprot/A1RU44 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/384616:PISL_RS02345 ^@ http://purl.uniprot.org/uniprot/A1RRQ3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family. http://togogenome.org/gene/384616:PISL_RS01695 ^@ http://purl.uniprot.org/uniprot/A1RRC5 ^@ Similarity ^@ Belongs to the complex I subunit 3 family. http://togogenome.org/gene/384616:PISL_RS07040 ^@ http://purl.uniprot.org/uniprot/A1RUA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobD/CbiB family.|||Cell membrane|||Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.|||Membrane http://togogenome.org/gene/384616:PISL_RS04805 ^@ http://purl.uniprot.org/uniprot/A1RT26 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/384616:PISL_RS01020 ^@ http://purl.uniprot.org/uniprot/A1RQZ7 ^@ Similarity ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. http://togogenome.org/gene/384616:PISL_RS06995 ^@ http://purl.uniprot.org/uniprot/A1RU93 ^@ Function|||Similarity ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. http://togogenome.org/gene/384616:PISL_RS08440 ^@ http://purl.uniprot.org/uniprot/A1RV13 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. http://togogenome.org/gene/384616:PISL_RS05540 ^@ http://purl.uniprot.org/uniprot/A1RTG6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/384616:PISL_RS08715 ^@ http://purl.uniprot.org/uniprot/A1RV68 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/384616:PISL_RS08890 ^@ http://purl.uniprot.org/uniprot/A1RVA2 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/384616:PISL_RS00855 ^@ http://purl.uniprot.org/uniprot/A1RQW7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS06145 ^@ http://purl.uniprot.org/uniprot/A1RTT2 ^@ Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/384616:PISL_RS02255 ^@ http://purl.uniprot.org/uniprot/A1RRN6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS19 family.|||May be involved in maturation of the 30S ribosomal subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/384616:PISL_RS09830 ^@ http://purl.uniprot.org/uniprot/A1RVS3 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/384616:PISL_RS01350 ^@ http://purl.uniprot.org/uniprot/A1RR58 ^@ Similarity ^@ Belongs to the PstS family. http://togogenome.org/gene/384616:PISL_RS06015 ^@ http://purl.uniprot.org/uniprot/A1RTQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.|||Belongs to the TiaS family.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS00495 ^@ http://purl.uniprot.org/uniprot/A1RQP5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. http://togogenome.org/gene/384616:PISL_RS02955 ^@ http://purl.uniprot.org/uniprot/A1RS21 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/384616:PISL_RS00645 ^@ http://purl.uniprot.org/uniprot/A1RQS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.|||Cell membrane|||Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. http://togogenome.org/gene/384616:PISL_RS08085 ^@ http://purl.uniprot.org/uniprot/A1RUU3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/384616:PISL_RS01100 ^@ http://purl.uniprot.org/uniprot/A1RR13 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS02880 ^@ http://purl.uniprot.org/uniprot/A1RS06 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/384616:PISL_RS06425 ^@ http://purl.uniprot.org/uniprot/A1RTY2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS03335 ^@ http://purl.uniprot.org/uniprot/A1RS91 ^@ Similarity ^@ Belongs to the ETF alpha-subunit/FixB family. http://togogenome.org/gene/384616:PISL_RS09595 ^@ http://purl.uniprot.org/uniprot/A1RVN4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/384616:PISL_RS02350 ^@ http://purl.uniprot.org/uniprot/A1RRQ4 ^@ Function|||Similarity ^@ Belongs to the eIF-6 family.|||Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. http://togogenome.org/gene/384616:PISL_RS08810 ^@ http://purl.uniprot.org/uniprot/A1RV87 ^@ Similarity ^@ Belongs to the myo-inositol 1-phosphate synthase family. http://togogenome.org/gene/384616:PISL_RS04625 ^@ http://purl.uniprot.org/uniprot/A1RSZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal NMN adenylyltransferase family.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS00410 ^@ http://purl.uniprot.org/uniprot/A1RQM9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS01485 ^@ http://purl.uniprot.org/uniprot/A1RR84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/384616:PISL_RS09275 ^@ http://purl.uniprot.org/uniprot/A1RVH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm|||Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. http://togogenome.org/gene/384616:PISL_RS07000 ^@ http://purl.uniprot.org/uniprot/A1RU94 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. PoK subfamily.|||Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway. http://togogenome.org/gene/384616:PISL_RS04315 ^@ http://purl.uniprot.org/uniprot/A1RST2 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/384616:PISL_RS08145 ^@ http://purl.uniprot.org/uniprot/A1RUV5 ^@ Similarity ^@ Belongs to the aconitase/IPM isomerase family. http://togogenome.org/gene/384616:PISL_RS03980 ^@ http://purl.uniprot.org/uniprot/A1RSL5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS1 family. http://togogenome.org/gene/384616:PISL_RS00915 ^@ http://purl.uniprot.org/uniprot/A1RQX7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS01035 ^@ http://purl.uniprot.org/uniprot/A1RR00 ^@ Similarity|||Subunit ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.|||Heterodimer of a large and a small subunit. http://togogenome.org/gene/384616:PISL_RS10080 ^@ http://purl.uniprot.org/uniprot/A1RVX2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS06595 ^@ http://purl.uniprot.org/uniprot/A1RU15 ^@ Function|||Similarity|||Subunit ^@ Belongs to the diphthine synthase family.|||Homodimer.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/384616:PISL_RS09005 ^@ http://purl.uniprot.org/uniprot/A1RVC4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 3 Mg(2+) ions per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/384616:PISL_RS03435 ^@ http://purl.uniprot.org/uniprot/A1RSB1 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs. http://togogenome.org/gene/384616:PISL_RS07190 ^@ http://purl.uniprot.org/uniprot/A1RUC9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS04585 ^@ http://purl.uniprot.org/uniprot/A1RSY5 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/384616:PISL_RS05110 ^@ http://purl.uniprot.org/uniprot/A1RT82 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane http://togogenome.org/gene/384616:PISL_RS06195 ^@ http://purl.uniprot.org/uniprot/A1RTU1 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/384616:PISL_RS00445 ^@ http://purl.uniprot.org/uniprot/A1RQN6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TYW1 family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).|||Cytoplasm|||Monomer. http://togogenome.org/gene/384616:PISL_RS02420 ^@ http://purl.uniprot.org/uniprot/A1RRR8 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/384616:PISL_RS02760 ^@ http://purl.uniprot.org/uniprot/A1RRY3 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/384616:PISL_RS05460 ^@ http://purl.uniprot.org/uniprot/A1RTF2 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/384616:PISL_RS03560 ^@ http://purl.uniprot.org/uniprot/A1RSD5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/384616:PISL_RS00570 ^@ http://purl.uniprot.org/uniprot/A1RQQ9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/384616:PISL_RS09805 ^@ http://purl.uniprot.org/uniprot/A1RVR8 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/384616:PISL_RS06275 ^@ http://purl.uniprot.org/uniprot/A1RTV5 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the asparaginase 1 family. GatD subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/384616:PISL_RS06065 ^@ http://purl.uniprot.org/uniprot/A1RTR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Membrane http://togogenome.org/gene/384616:PISL_RS04060 ^@ http://purl.uniprot.org/uniprot/A1RSN2 ^@ Function|||Similarity ^@ Belongs to the archaeal SPP-like hydrolase family.|||Catalyzes the dephosphorylation of 2-phosphoglycolate. http://togogenome.org/gene/384616:PISL_RS01435 ^@ http://purl.uniprot.org/uniprot/A1RR73 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.|||Cytoplasm|||Involved in both the arginine and lysine biosynthetic pathways. http://togogenome.org/gene/384616:PISL_RS07855 ^@ http://purl.uniprot.org/uniprot/A1RUQ2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/384616:PISL_RS05685 ^@ http://purl.uniprot.org/uniprot/A1RTJ4 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/384616:PISL_RS00650 ^@ http://purl.uniprot.org/uniprot/A1RQS5 ^@ Similarity ^@ Belongs to the TrpC family. http://togogenome.org/gene/384616:PISL_RS04310 ^@ http://purl.uniprot.org/uniprot/A1RST1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRP4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. http://togogenome.org/gene/384616:PISL_RS06855 ^@ http://purl.uniprot.org/uniprot/A1RU66 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/384616:PISL_RS00860 ^@ http://purl.uniprot.org/uniprot/A1RQW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DsrC/TusE family.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS03775 ^@ http://purl.uniprot.org/uniprot/A1RSH9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/384616:PISL_RS02035 ^@ http://purl.uniprot.org/uniprot/A1RRJ4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/384616:PISL_RS02380 ^@ http://purl.uniprot.org/uniprot/A1RRR0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/384616:PISL_RS08040 ^@ http://purl.uniprot.org/uniprot/A1RUT4 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/384616:PISL_RS03640 ^@ http://purl.uniprot.org/uniprot/A1RSF2 ^@ Function|||Similarity ^@ Belongs to the V-ATPase E subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/384616:PISL_RS06125 ^@ http://purl.uniprot.org/uniprot/A1RTS8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/384616:PISL_RS02005 ^@ http://purl.uniprot.org/uniprot/A1RRI8 ^@ Similarity ^@ Belongs to the type IA topoisomerase family. http://togogenome.org/gene/384616:PISL_RS07465 ^@ http://purl.uniprot.org/uniprot/A1RUI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Membrane http://togogenome.org/gene/384616:PISL_RS04610 ^@ http://purl.uniprot.org/uniprot/A1RSY9 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/384616:PISL_RS05535 ^@ http://purl.uniprot.org/uniprot/A1RTG5 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the TFE family.|||Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.|||The winged helix domain is involved in binding to DNA in the preinitiation complex.|||Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes. http://togogenome.org/gene/384616:PISL_RS02820 ^@ http://purl.uniprot.org/uniprot/A1RRZ5 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/384616:PISL_RS02930 ^@ http://purl.uniprot.org/uniprot/A1RS16 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A single active site specifically recognizes both ATP and CTP and is responsible for their addition.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.|||Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.|||Homodimer. http://togogenome.org/gene/384616:PISL_RS00425 ^@ http://purl.uniprot.org/uniprot/A1RQN2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS05290 ^@ http://purl.uniprot.org/uniprot/A1RTB9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/384616:PISL_RS04040 ^@ http://purl.uniprot.org/uniprot/A1RSM8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS06735 ^@ http://purl.uniprot.org/uniprot/A1RU41 ^@ Similarity ^@ Belongs to the peptidase S9C family. http://togogenome.org/gene/384616:PISL_RS09135 ^@ http://purl.uniprot.org/uniprot/A1RVE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS00655 ^@ http://purl.uniprot.org/uniprot/A1RQS6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS02250 ^@ http://purl.uniprot.org/uniprot/A1RRN5 ^@ Similarity ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. http://togogenome.org/gene/384616:PISL_RS08785 ^@ http://purl.uniprot.org/uniprot/A1RV82 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).|||Cytoplasm|||Homodimer.|||The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself. http://togogenome.org/gene/384616:PISL_RS04300 ^@ http://purl.uniprot.org/uniprot/A1RSS9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp42 subfamily.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. http://togogenome.org/gene/384616:PISL_RS09850 ^@ http://purl.uniprot.org/uniprot/A1RVS7 ^@ Function ^@ The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/384616:PISL_RS10365 ^@ http://purl.uniprot.org/uniprot/A1RW28 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS05620 ^@ http://purl.uniprot.org/uniprot/A1RTI3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/384616:PISL_RS06680 ^@ http://purl.uniprot.org/uniprot/A1RU31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS06875 ^@ http://purl.uniprot.org/uniprot/A1RU70 ^@ Similarity ^@ In the C-terminal section; belongs to the trehalose phosphatase family. http://togogenome.org/gene/384616:PISL_RS04000 ^@ http://purl.uniprot.org/uniprot/A1RSL9 ^@ Cofactor|||Function|||Subunit ^@ Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.|||Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer composed of an alpha and a beta subunit.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/384616:PISL_RS03015 ^@ http://purl.uniprot.org/uniprot/A1RS32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS04620 ^@ http://purl.uniprot.org/uniprot/A1RSZ1 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/384616:PISL_RS01680 ^@ http://purl.uniprot.org/uniprot/A1RRC2 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/384616:PISL_RS01690 ^@ http://purl.uniprot.org/uniprot/A1RRC4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS10320 ^@ http://purl.uniprot.org/uniprot/A1RW20 ^@ Similarity ^@ Belongs to the UPF0251 family. http://togogenome.org/gene/384616:PISL_RS08645 ^@ http://purl.uniprot.org/uniprot/A1RV54 ^@ Function|||Similarity ^@ Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).|||Belongs to the archease family. http://togogenome.org/gene/384616:PISL_RS03115 ^@ http://purl.uniprot.org/uniprot/A1RS49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/384616:PISL_RS07540 ^@ http://purl.uniprot.org/uniprot/A1RUJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/384616:PISL_RS03510 ^@ http://purl.uniprot.org/uniprot/A1RSC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.|||Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS03990 ^@ http://purl.uniprot.org/uniprot/A1RSL7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/384616:PISL_RS03300 ^@ http://purl.uniprot.org/uniprot/A1RS86 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DtdA deacylase family.|||Binds 2 Zn(2+) ions per subunit.|||D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.|||Monomer. http://togogenome.org/gene/384616:PISL_RS03590 ^@ http://purl.uniprot.org/uniprot/A1RSE2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL18 family. http://togogenome.org/gene/384616:PISL_RS01730 ^@ http://purl.uniprot.org/uniprot/A1RRD2 ^@ Similarity ^@ Belongs to the complex I 20 kDa subunit family. http://togogenome.org/gene/384616:PISL_RS08835 ^@ http://purl.uniprot.org/uniprot/A1RV91 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/384616:PISL_RS03390 ^@ http://purl.uniprot.org/uniprot/A1RSA2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcS subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/384616:PISL_RS08850 ^@ http://purl.uniprot.org/uniprot/A1RV94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Membrane http://togogenome.org/gene/384616:PISL_RS09870 ^@ http://purl.uniprot.org/uniprot/A1RVT1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/384616:PISL_RS06215 ^@ http://purl.uniprot.org/uniprot/A1RTU5 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/384616:PISL_RS08330 ^@ http://purl.uniprot.org/uniprot/A1RUZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS02180 ^@ http://purl.uniprot.org/uniprot/A1RRM2 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/384616:PISL_RS07820 ^@ http://purl.uniprot.org/uniprot/A1RUP6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS07145 ^@ http://purl.uniprot.org/uniprot/A1RUC0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the YjjX NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Homodimer.|||Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/384616:PISL_RS02385 ^@ http://purl.uniprot.org/uniprot/A1RRR1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. Probably involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA. http://togogenome.org/gene/384616:PISL_RS01935 ^@ http://purl.uniprot.org/uniprot/A1RRH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUA5 family.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/384616:PISL_RS03480 ^@ http://purl.uniprot.org/uniprot/A1RSC0 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/384616:PISL_RS05490 ^@ http://purl.uniprot.org/uniprot/A1RTF7 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.|||Heterooligomer of catalytic and regulatory chains. http://togogenome.org/gene/384616:PISL_RS09070 ^@ http://purl.uniprot.org/uniprot/A1RVD1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/384616:PISL_RS02990 ^@ http://purl.uniprot.org/uniprot/A1RS28 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Homohexamer. Dimer of a homotrimer. http://togogenome.org/gene/384616:PISL_RS05920 ^@ http://purl.uniprot.org/uniprot/A1RTP1 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/384616:PISL_RS03240 ^@ http://purl.uniprot.org/uniprot/A1RS74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS08735 ^@ http://purl.uniprot.org/uniprot/A1RV72 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/384616:PISL_RS04145 ^@ http://purl.uniprot.org/uniprot/A1RSP9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.|||Belongs to the Holliday junction resolvase Hjc family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer. http://togogenome.org/gene/384616:PISL_RS00415 ^@ http://purl.uniprot.org/uniprot/A1RQN0 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. http://togogenome.org/gene/384616:PISL_RS01050 ^@ http://purl.uniprot.org/uniprot/A1RR03 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/384616:PISL_RS06255 ^@ http://purl.uniprot.org/uniprot/A1RTV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS05285 ^@ http://purl.uniprot.org/uniprot/A1RTB8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/384616:PISL_RS02010 ^@ http://purl.uniprot.org/uniprot/A1RRI9 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family.|||Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). http://togogenome.org/gene/384616:PISL_RS01480 ^@ http://purl.uniprot.org/uniprot/A1RR83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/384616:PISL_RS05435 ^@ http://purl.uniprot.org/uniprot/A1RTE7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS09200 ^@ http://purl.uniprot.org/uniprot/A1RVF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS02240 ^@ http://purl.uniprot.org/uniprot/A1RRN3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase small subunit family.|||Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL). http://togogenome.org/gene/384616:PISL_RS06150 ^@ http://purl.uniprot.org/uniprot/A1RTT3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/384616:PISL_RS04250 ^@ http://purl.uniprot.org/uniprot/A1RSR9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. BUD32 family. http://togogenome.org/gene/384616:PISL_RS02220 ^@ http://purl.uniprot.org/uniprot/A1RRM8 ^@ Function|||Similarity ^@ Belongs to the NOP10 family.|||Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. http://togogenome.org/gene/384616:PISL_RS08995 ^@ http://purl.uniprot.org/uniprot/A1RVC2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the thymidylate synthase ThyX family.|||Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/384616:PISL_RS03425 ^@ http://purl.uniprot.org/uniprot/A1RSA9 ^@ Function|||Similarity ^@ Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). http://togogenome.org/gene/384616:PISL_RS07835 ^@ http://purl.uniprot.org/uniprot/A1RUP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/384616:PISL_RS02225 ^@ http://purl.uniprot.org/uniprot/A1RRM9 ^@ Similarity ^@ Belongs to the eIF-2-alpha family. http://togogenome.org/gene/384616:PISL_RS04750 ^@ http://purl.uniprot.org/uniprot/A1RT15 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Spt4 family.|||Heterodimer composed of Spt4 and Spt5.|||Stimulates transcription elongation. http://togogenome.org/gene/384616:PISL_RS03625 ^@ http://purl.uniprot.org/uniprot/A1RSE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA polymerase beta chain family.|||Cytoplasm|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/384616:PISL_RS06775 ^@ http://purl.uniprot.org/uniprot/A1RU50 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/384616:PISL_RS02560 ^@ http://purl.uniprot.org/uniprot/A1RRU5 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/384616:PISL_RS01085 ^@ http://purl.uniprot.org/uniprot/A1RR10 ^@ Function ^@ Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/384616:PISL_RS02965 ^@ http://purl.uniprot.org/uniprot/A1RS23 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/384616:PISL_RS10115 ^@ http://purl.uniprot.org/uniprot/A1RVX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DsrC/TusE family.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS08775 ^@ http://purl.uniprot.org/uniprot/A1RV80 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/384616:PISL_RS03610 ^@ http://purl.uniprot.org/uniprot/A1RSE6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/384616:PISL_RS08665 ^@ http://purl.uniprot.org/uniprot/A1RV58 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycerol-1-phosphate dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/384616:PISL_RS01565 ^@ http://purl.uniprot.org/uniprot/A1RR99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm|||Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.|||Heterodimer of two subunits, one of which binds GTP. http://togogenome.org/gene/384616:PISL_RS09865 ^@ http://purl.uniprot.org/uniprot/A1RVT0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer. http://togogenome.org/gene/384616:PISL_RS07840 ^@ http://purl.uniprot.org/uniprot/A1RUQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/384616:PISL_RS02960 ^@ http://purl.uniprot.org/uniprot/A1RS22 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP19 family.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/384616:PISL_RS05100 ^@ http://purl.uniprot.org/uniprot/A1RT80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/384616:PISL_RS02775 ^@ http://purl.uniprot.org/uniprot/A1RRY6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/384616:PISL_RS02115 ^@ http://purl.uniprot.org/uniprot/A1RRL0 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/384616:PISL_RS05570 ^@ http://purl.uniprot.org/uniprot/A1RTH1 ^@ Similarity ^@ Belongs to the snRNP Sm proteins family. http://togogenome.org/gene/384616:PISL_RS06085 ^@ http://purl.uniprot.org/uniprot/A1RTS0 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/384616:PISL_RS04230 ^@ http://purl.uniprot.org/uniprot/A1RSR6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/384616:PISL_RS09755 ^@ http://purl.uniprot.org/uniprot/A1RVQ9 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS31 family.|||Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/384616:PISL_RS02535 ^@ http://purl.uniprot.org/uniprot/A1RRU0 ^@ Function|||Similarity ^@ Belongs to the GTP-dependent DPCK family.|||Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). http://togogenome.org/gene/384616:PISL_RS01310 ^@ http://purl.uniprot.org/uniprot/A1RR50 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PEPCase type 2 family.|||Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.|||Homotetramer. http://togogenome.org/gene/384616:PISL_RS05020 ^@ http://purl.uniprot.org/uniprot/A1RT66 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/384616:PISL_RS02975 ^@ http://purl.uniprot.org/uniprot/A1RS25 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.|||Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure. http://togogenome.org/gene/384616:PISL_RS08220 ^@ http://purl.uniprot.org/uniprot/A1RUX0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.|||Belongs to the Cren7 family.|||Cytoplasm|||Methylated at multiple sites, to varying extents.|||Monomer. http://togogenome.org/gene/384616:PISL_RS04375 ^@ http://purl.uniprot.org/uniprot/A1RSU3 ^@ Function ^@ Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA. http://togogenome.org/gene/384616:PISL_RS06635 ^@ http://purl.uniprot.org/uniprot/A1RU22 ^@ Similarity ^@ Belongs to the RimK family. LysX subfamily. http://togogenome.org/gene/384616:PISL_RS08865 ^@ http://purl.uniprot.org/uniprot/A1RV98 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/384616:PISL_RS06335 ^@ http://purl.uniprot.org/uniprot/A1RTW6 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/384616:PISL_RS03620 ^@ http://purl.uniprot.org/uniprot/A1RSE8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds at least 2 Zn(2+) per subunit.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/384616:PISL_RS01070 ^@ http://purl.uniprot.org/uniprot/A1RR07 ^@ Similarity ^@ Belongs to the carbamoyltransferase HypF family. http://togogenome.org/gene/384616:PISL_RS10120 ^@ http://purl.uniprot.org/uniprot/A1RVX9 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/384616:PISL_RS08340 ^@ http://purl.uniprot.org/uniprot/A1RUZ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS08585 ^@ http://purl.uniprot.org/uniprot/A1RV42 ^@ Cofactor ^@ Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/384616:PISL_RS03940 ^@ http://purl.uniprot.org/uniprot/A1RSK8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/384616:PISL_RS03580 ^@ http://purl.uniprot.org/uniprot/A1RSE0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/384616:PISL_RS05645 ^@ http://purl.uniprot.org/uniprot/A1RTI8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/384616:PISL_RS00245 ^@ http://purl.uniprot.org/uniprot/A1RQJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/384616:PISL_RS03525 ^@ http://purl.uniprot.org/uniprot/A1RSC9 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/384616:PISL_RS00555 ^@ http://purl.uniprot.org/uniprot/A1RQQ6 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/384616:PISL_RS02565 ^@ http://purl.uniprot.org/uniprot/A1RRU6 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/384616:PISL_RS08860 ^@ http://purl.uniprot.org/uniprot/A1RV97 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/384616:PISL_RS00465 ^@ http://purl.uniprot.org/uniprot/A1RQN9 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/384616:PISL_RS01965 ^@ http://purl.uniprot.org/uniprot/A1RRI0 ^@ Function|||Similarity ^@ Belongs to the archaeal-type GTP cyclohydrolase family.|||Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity. http://togogenome.org/gene/384616:PISL_RS09810 ^@ http://purl.uniprot.org/uniprot/P81901 ^@ Cofactor|||Function|||Miscellaneous|||PTM|||Subunit ^@ Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.|||Has a maximum absorption at about 282 nm.|||Monomer.|||The N-terminus is blocked. http://togogenome.org/gene/384616:PISL_RS04705 ^@ http://purl.uniprot.org/uniprot/A1RT06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/384616:PISL_RS02495 ^@ http://purl.uniprot.org/uniprot/A1RRT2 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family.|||Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. http://togogenome.org/gene/384616:PISL_RS07345 ^@ http://purl.uniprot.org/uniprot/A1RUF7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/384616:PISL_RS03600 ^@ http://purl.uniprot.org/uniprot/A1RSE4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Part of the 30S ribosomal subunit.|||With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. http://togogenome.org/gene/384616:PISL_RS03175 ^@ http://purl.uniprot.org/uniprot/A1RS61 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/384616:PISL_RS03465 ^@ http://purl.uniprot.org/uniprot/A1RSB7 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. http://togogenome.org/gene/384616:PISL_RS05775 ^@ http://purl.uniprot.org/uniprot/A1RTL2 ^@ Function ^@ Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA. http://togogenome.org/gene/384616:PISL_RS08770 ^@ http://purl.uniprot.org/uniprot/A1RV79 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/384616:PISL_RS08435 ^@ http://purl.uniprot.org/uniprot/A1RV12 ^@ Similarity ^@ Belongs to the peptidase M1 family. http://togogenome.org/gene/384616:PISL_RS08515 ^@ http://purl.uniprot.org/uniprot/A1RV28 ^@ Similarity ^@ Belongs to the UPF0201 family. http://togogenome.org/gene/384616:PISL_RS02270 ^@ http://purl.uniprot.org/uniprot/A1RRN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GGGP/HepGP synthase family. Group II subfamily.|||Cytoplasm|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/384616:PISL_RS05735 ^@ http://purl.uniprot.org/uniprot/A1RTK4 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent DNA ligase family.|||DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. http://togogenome.org/gene/384616:PISL_RS02575 ^@ http://purl.uniprot.org/uniprot/A1RRU8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/384616:PISL_RS06190 ^@ http://purl.uniprot.org/uniprot/A1RTU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/384616:PISL_RS02530 ^@ http://purl.uniprot.org/uniprot/A1RRT9 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/384616:PISL_RS01810 ^@ http://purl.uniprot.org/uniprot/A1RRE8 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/384616:PISL_RS02875 ^@ http://purl.uniprot.org/uniprot/A1RS05 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||Located at the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/384616:PISL_RS04305 ^@ http://purl.uniprot.org/uniprot/A1RST0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp41 subfamily.|||Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteromeric RNA-tails.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS00995 ^@ http://purl.uniprot.org/uniprot/A1RQZ2 ^@ Function|||Similarity ^@ Belongs to the HypA/HybF family.|||Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. http://togogenome.org/gene/384616:PISL_RS01790 ^@ http://purl.uniprot.org/uniprot/A1RRE4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/384616:PISL_RS03890 ^@ http://purl.uniprot.org/uniprot/A1RSJ8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/384616:PISL_RS06655 ^@ http://purl.uniprot.org/uniprot/A1RU26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.|||Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS05525 ^@ http://purl.uniprot.org/uniprot/A1RTG3 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the archaeosine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/384616:PISL_RS02525 ^@ http://purl.uniprot.org/uniprot/A1RRT7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.|||Monomer.|||The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity. http://togogenome.org/gene/384616:PISL_RS00540 ^@ http://purl.uniprot.org/uniprot/A1RQQ3 ^@ Cofactor|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/384616:PISL_RS01375 ^@ http://purl.uniprot.org/uniprot/A1RR61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NrfD family.|||Membrane http://togogenome.org/gene/384616:PISL_RS00160 ^@ http://purl.uniprot.org/uniprot/A1RQI1 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/384616:PISL_RS02630 ^@ http://purl.uniprot.org/uniprot/A1RRV7 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruD family.|||Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs. http://togogenome.org/gene/384616:PISL_RS08445 ^@ http://purl.uniprot.org/uniprot/A1RV14 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/384616:PISL_RS09475 ^@ http://purl.uniprot.org/uniprot/A1RVL2 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/384616:PISL_RS04175 ^@ http://purl.uniprot.org/uniprot/A1RSQ5 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. UPF0219 family. http://togogenome.org/gene/384616:PISL_RS00260 ^@ http://purl.uniprot.org/uniprot/A1RQK2 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethane group. http://togogenome.org/gene/384616:PISL_RS08255 ^@ http://purl.uniprot.org/uniprot/A1RUX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/384616:PISL_RS00870 ^@ http://purl.uniprot.org/uniprot/A1RQX0 ^@ Similarity ^@ Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. http://togogenome.org/gene/384616:PISL_RS00505 ^@ http://purl.uniprot.org/uniprot/A1RQP7 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/384616:PISL_RS01945 ^@ http://purl.uniprot.org/uniprot/A1RRH6 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/384616:PISL_RS03000 ^@ http://purl.uniprot.org/uniprot/A1RS30 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/384616:PISL_RS09580 ^@ http://purl.uniprot.org/uniprot/A1RVN1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/384616:PISL_RS09410 ^@ http://purl.uniprot.org/uniprot/A1RVK0 ^@ Similarity ^@ Belongs to the transcriptional regulatory CopG/NikR family. http://togogenome.org/gene/384616:PISL_RS04210 ^@ http://purl.uniprot.org/uniprot/A1RSR2 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/384616:PISL_RS02935 ^@ http://purl.uniprot.org/uniprot/A1RS17 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/384616:PISL_RS05405 ^@ http://purl.uniprot.org/uniprot/A1RTE0 ^@ Similarity ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. http://togogenome.org/gene/384616:PISL_RS07815 ^@ http://purl.uniprot.org/uniprot/A1RUP5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS08885 ^@ http://purl.uniprot.org/uniprot/A1RVA1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/384616:PISL_RS01775 ^@ http://purl.uniprot.org/uniprot/A1RRE1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/384616:PISL_RS06685 ^@ http://purl.uniprot.org/uniprot/A1RU32 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/384616:PISL_RS01660 ^@ http://purl.uniprot.org/uniprot/A1RRB8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS06230 ^@ http://purl.uniprot.org/uniprot/A1RTU8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP phosphoribosyltransferase family. Long subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Feedback inhibited by histidine. http://togogenome.org/gene/384616:PISL_RS09575 ^@ http://purl.uniprot.org/uniprot/A1RVN0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/384616:PISL_RS03095 ^@ http://purl.uniprot.org/uniprot/A1RS46 ^@ Function ^@ Catalyzes the synthesis of GMP from XMP. http://togogenome.org/gene/384616:PISL_RS04155 ^@ http://purl.uniprot.org/uniprot/A1RSQ1 ^@ Function|||Similarity ^@ Belongs to the TBP family.|||General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. http://togogenome.org/gene/384616:PISL_RS06185 ^@ http://purl.uniprot.org/uniprot/A1RTT9 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/384616:PISL_RS05640 ^@ http://purl.uniprot.org/uniprot/A1RTI7 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/384616:PISL_RS08560 ^@ http://purl.uniprot.org/uniprot/A1RV37 ^@ Function|||Similarity ^@ Belongs to the TFIIB family.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/384616:PISL_RS03595 ^@ http://purl.uniprot.org/uniprot/A1RSE3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/384616:PISL_RS02985 ^@ http://purl.uniprot.org/uniprot/A1RS27 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Cytoplasm|||Functions by promoting the formation of the first peptide bond. http://togogenome.org/gene/384616:PISL_RS06985 ^@ http://purl.uniprot.org/uniprot/A1RU91 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal phosphopantothenate synthetase family.|||Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.|||Homodimer. http://togogenome.org/gene/384616:PISL_RS02545 ^@ http://purl.uniprot.org/uniprot/A1RRU2 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/384616:PISL_RS09585 ^@ http://purl.uniprot.org/uniprot/A1RVN2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/384616:PISL_RS05605 ^@ http://purl.uniprot.org/uniprot/A1RTI0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/384616:PISL_RS02060 ^@ http://purl.uniprot.org/uniprot/A1RRJ9 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the GatB/GatE family. GatE subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/384616:PISL_RS03605 ^@ http://purl.uniprot.org/uniprot/A1RSE5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NusA family.|||Cytoplasm|||Participates in transcription termination. http://togogenome.org/gene/384616:PISL_RS02605 ^@ http://purl.uniprot.org/uniprot/A1RRV2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer. http://togogenome.org/gene/384616:PISL_RS01595 ^@ http://purl.uniprot.org/uniprot/A1RRA5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/384616:PISL_RS06130 ^@ http://purl.uniprot.org/uniprot/A1RTS9 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/384616:PISL_RS09380 ^@ http://purl.uniprot.org/uniprot/A1RVJ4 ^@ Function ^@ Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. http://togogenome.org/gene/384616:PISL_RS02835 ^@ http://purl.uniprot.org/uniprot/A1RRZ8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. http://togogenome.org/gene/384616:PISL_RS08325 ^@ http://purl.uniprot.org/uniprot/A1RUZ1 ^@ Similarity ^@ Belongs to the carbamate kinase family. http://togogenome.org/gene/384616:PISL_RS04615 ^@ http://purl.uniprot.org/uniprot/A1RSZ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS08505 ^@ http://purl.uniprot.org/uniprot/A1RV26 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. http://togogenome.org/gene/384616:PISL_RS10345 ^@ http://purl.uniprot.org/uniprot/A1RW25 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/384616:PISL_RS06325 ^@ http://purl.uniprot.org/uniprot/A1RTW4 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/384616:PISL_RS04790 ^@ http://purl.uniprot.org/uniprot/A1RT23 ^@ Similarity ^@ Belongs to the BtpA family. http://togogenome.org/gene/384616:PISL_RS02815 ^@ http://purl.uniprot.org/uniprot/A1RRZ4 ^@ Function|||Similarity ^@ Belongs to the THEP1 NTPase family.|||Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency. http://togogenome.org/gene/384616:PISL_RS04960 ^@ http://purl.uniprot.org/uniprot/A1RT54 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the archaeal DnaG primase family.|||Binds two Mg(2+) per subunit.|||Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome. http://togogenome.org/gene/384616:PISL_RS05635 ^@ http://purl.uniprot.org/uniprot/A1RTI6 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/384616:PISL_RS07960 ^@ http://purl.uniprot.org/uniprot/A1RUS1 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/384616:PISL_RS08600 ^@ http://purl.uniprot.org/uniprot/A1RV45 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/384616:PISL_RS06035 ^@ http://purl.uniprot.org/uniprot/A1RTR0 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/384616:PISL_RS01600 ^@ http://purl.uniprot.org/uniprot/A1RRA6 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.|||Cell membrane|||Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. http://togogenome.org/gene/384616:PISL_RS06200 ^@ http://purl.uniprot.org/uniprot/A1RTU2 ^@ Similarity ^@ Belongs to the isopentenyl phosphate kinase family. http://togogenome.org/gene/384616:PISL_RS06945 ^@ http://purl.uniprot.org/uniprot/A1RU83 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS04290 ^@ http://purl.uniprot.org/uniprot/A1RSS7 ^@ Function ^@ Probably involved in the biogenesis of the ribosome. http://togogenome.org/gene/384616:PISL_RS06405 ^@ http://purl.uniprot.org/uniprot/A1RTX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS09750 ^@ http://purl.uniprot.org/uniprot/A1RVQ8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. http://togogenome.org/gene/384616:PISL_RS03295 ^@ http://purl.uniprot.org/uniprot/A1RS85 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/384616:PISL_RS03395 ^@ http://purl.uniprot.org/uniprot/A1RSA3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcL subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/384616:PISL_RS08675 ^@ http://purl.uniprot.org/uniprot/A1RV60 ^@ Similarity ^@ Belongs to the malic enzymes family. http://togogenome.org/gene/384616:PISL_RS02260 ^@ http://purl.uniprot.org/uniprot/A1RRN7 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/384616:PISL_RS03120 ^@ http://purl.uniprot.org/uniprot/A1RS50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/384616:PISL_RS09250 ^@ http://purl.uniprot.org/uniprot/A1RVG9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/384616:PISL_RS04280 ^@ http://purl.uniprot.org/uniprot/A1RSS5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/384616:PISL_RS02230 ^@ http://purl.uniprot.org/uniprot/A1RRN1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/384616:PISL_RS08540 ^@ http://purl.uniprot.org/uniprot/A1RV33 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/384616:PISL_RS08750 ^@ http://purl.uniprot.org/uniprot/A1RV75 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/384616:PISL_RS05630 ^@ http://purl.uniprot.org/uniprot/A1RTI5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/384616:PISL_RS04190 ^@ http://purl.uniprot.org/uniprot/A1RSQ8 ^@ Similarity ^@ Belongs to the HMG-CoA reductase family. http://togogenome.org/gene/384616:PISL_RS03020 ^@ http://purl.uniprot.org/uniprot/A1RS33 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/384616:PISL_RS05770 ^@ http://purl.uniprot.org/uniprot/A1RTL1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS05060 ^@ http://purl.uniprot.org/uniprot/A1RT74 ^@ Similarity|||Subunit ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Homohexamer. http://togogenome.org/gene/384616:PISL_RS02425 ^@ http://purl.uniprot.org/uniprot/A1RRR9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS02050 ^@ http://purl.uniprot.org/uniprot/A1RRJ7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyltransferase superfamily. Fibrillarin family.|||Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.|||Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. http://togogenome.org/gene/384616:PISL_RS00920 ^@ http://purl.uniprot.org/uniprot/A1RQX8 ^@ Domain|||Function|||Miscellaneous|||Similarity ^@ Belongs to the CobB/CbiA family.|||Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.|||Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.|||The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate. http://togogenome.org/gene/384616:PISL_RS09115 ^@ http://purl.uniprot.org/uniprot/A1RVE0 ^@ Similarity ^@ Belongs to the EPSP synthase family. http://togogenome.org/gene/384616:PISL_RS08615 ^@ http://purl.uniprot.org/uniprot/A1RV48 ^@ Similarity ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. http://togogenome.org/gene/384616:PISL_RS00600 ^@ http://purl.uniprot.org/uniprot/A1RQR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm http://togogenome.org/gene/384616:PISL_RS09210 ^@ http://purl.uniprot.org/uniprot/A1RVG1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/384616:PISL_RS04025 ^@ http://purl.uniprot.org/uniprot/A1RSM4 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/384616:PISL_RS03800 ^@ http://purl.uniprot.org/uniprot/A1RSI3 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/384616:PISL_RS04645 ^@ http://purl.uniprot.org/uniprot/A1RSZ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS06580 ^@ http://purl.uniprot.org/uniprot/A1RU12 ^@ Function|||Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. http://togogenome.org/gene/384616:PISL_RS00925 ^@ http://purl.uniprot.org/uniprot/A1RQX9 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/384616:PISL_RS07460 ^@ http://purl.uniprot.org/uniprot/A1RUH9 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/384616:PISL_RS06615 ^@ http://purl.uniprot.org/uniprot/A1RU18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Membrane http://togogenome.org/gene/384616:PISL_RS01405 ^@ http://purl.uniprot.org/uniprot/A1RR67 ^@ Caution|||Function|||PTM|||Similarity ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.|||Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/384616:PISL_RS05220 ^@ http://purl.uniprot.org/uniprot/A1RTA4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/384616:PISL_RS01570 ^@ http://purl.uniprot.org/uniprot/A1RRA0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/384616:PISL_RS00220 ^@ http://purl.uniprot.org/uniprot/A1RQJ4 ^@ Similarity|||Subunit ^@ Belongs to the ALAD family.|||Homooctamer. http://togogenome.org/gene/384616:PISL_RS06860 ^@ http://purl.uniprot.org/uniprot/A1RU67 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/384616:PISL_RS03285 ^@ http://purl.uniprot.org/uniprot/A1RS83 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/384616:PISL_RS04160 ^@ http://purl.uniprot.org/uniprot/A1RSQ2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/384616:PISL_RS04660 ^@ http://purl.uniprot.org/uniprot/A1RSZ8 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/384616:PISL_RS06795 ^@ http://purl.uniprot.org/uniprot/A1RU54 ^@ Function|||Similarity ^@ Belongs to the MqnA/MqnD family. MqnA subfamily.|||Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). http://togogenome.org/gene/384616:PISL_RS04980 ^@ http://purl.uniprot.org/uniprot/A1RT57 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/384616:PISL_RS03160 ^@ http://purl.uniprot.org/uniprot/A1RS58 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily.|||Catalyzes the reversible oxidation of malate to oxaloacetate. Exhibits higher specific activity for oxaloacetate reduction than for malate oxidation in vitro. Has a strong preference for NAD. Can use NADPH for oxaloacetate reduction, but activity decreases more than 90%. No activity detected with NADP(+) and malate.|||Homotetramer. http://togogenome.org/gene/384616:PISL_RS03935 ^@ http://purl.uniprot.org/uniprot/A1RSK7 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/384616:PISL_RS02265 ^@ http://purl.uniprot.org/uniprot/A1RRN8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/384616:PISL_RS08730 ^@ http://purl.uniprot.org/uniprot/A1RV71 ^@ Function|||Similarity|||Subunit ^@ Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.|||Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.|||Homotetramer; dimer of dimers.|||Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate. http://togogenome.org/gene/384616:PISL_RS02360 ^@ http://purl.uniprot.org/uniprot/A1RRQ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/384616:PISL_RS04415 ^@ http://purl.uniprot.org/uniprot/A1RSV1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.|||Belongs to the histone-like Alba family.|||Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.|||Chromosome|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/384616:PISL_RS06260 ^@ http://purl.uniprot.org/uniprot/A1RTV4 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Monomer. http://togogenome.org/gene/384616:PISL_RS02030 ^@ http://purl.uniprot.org/uniprot/A1RRJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/384616:PISL_RS10275 ^@ http://purl.uniprot.org/uniprot/A1RW10 ^@ Cofactor ^@ Binds 4 [4Fe-4S] clusters per subunit. http://togogenome.org/gene/384616:PISL_RS01345 ^@ http://purl.uniprot.org/uniprot/A1RR57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.