http://togogenome.org/gene/43179:Vma21 ^@ http://purl.uniprot.org/uniprot/I3MGT9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the V0 complex of the vacuolar ATPase (V-ATPase).|||Belongs to the VMA21 family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. http://togogenome.org/gene/43179:Fgf13 ^@ http://purl.uniprot.org/uniprot/I3MLX9 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/43179:Klhl15 ^@ http://purl.uniprot.org/uniprot/I3LZY7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/43179:ACI67_gp12 ^@ http://purl.uniprot.org/uniprot/A0A0U2CL62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 2 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/43179:Med14 ^@ http://purl.uniprot.org/uniprot/A0A287CYU0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 14 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/43179:Rab33a ^@ http://purl.uniprot.org/uniprot/I3MBJ6 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/43179:Btk ^@ http://purl.uniprot.org/uniprot/I3M4T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cytoplasm http://togogenome.org/gene/43179:Taf1 ^@ http://purl.uniprot.org/uniprot/I3MQI9|||http://purl.uniprot.org/uniprot/I3N3C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF1 family.|||Nucleus http://togogenome.org/gene/43179:Stag2 ^@ http://purl.uniprot.org/uniprot/A0A287D4D6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/43179:Armcx3 ^@ http://purl.uniprot.org/uniprot/I3MCW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eutherian X-chromosome-specific Armcx family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/43179:Fam199x ^@ http://purl.uniprot.org/uniprot/I3MCK2 ^@ Similarity ^@ Belongs to the FAM199 family. http://togogenome.org/gene/43179:LOC101975550 ^@ http://purl.uniprot.org/uniprot/I3M427 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/43179:Timp1 ^@ http://purl.uniprot.org/uniprot/I3M740 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/43179:Xkrx ^@ http://purl.uniprot.org/uniprot/I3M5J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/43179:Bmx ^@ http://purl.uniprot.org/uniprot/A0A287D7K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cytoplasm http://togogenome.org/gene/43179:S100g ^@ http://purl.uniprot.org/uniprot/I3LZ85 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/43179:Tmem35a ^@ http://purl.uniprot.org/uniprot/I3M5M8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/43179:Rab39b ^@ http://purl.uniprot.org/uniprot/I3MGX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/43179:Septin6 ^@ http://purl.uniprot.org/uniprot/A0A287D365|||http://purl.uniprot.org/uniprot/A0A287DGI4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/43179:Pfkfb1 ^@ http://purl.uniprot.org/uniprot/A0A287CUC5|||http://purl.uniprot.org/uniprot/I3MQX9 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/43179:Fgf16 ^@ http://purl.uniprot.org/uniprot/I3MNJ1 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/43179:Nsdhl ^@ http://purl.uniprot.org/uniprot/I3N7T2 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/43179:Gpkow ^@ http://purl.uniprot.org/uniprot/I3MN80 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MOS2 family.|||Nucleus|||RNA-binding protein involved in pre-mRNA splicing. http://togogenome.org/gene/43179:Usp51 ^@ http://purl.uniprot.org/uniprot/I3MRB9 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/43179:Agtr2 ^@ http://purl.uniprot.org/uniprot/I3MJB1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MTUS1.|||Membrane http://togogenome.org/gene/43179:ACI67_gp10 ^@ http://purl.uniprot.org/uniprot/A0A0U2CKU7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/43179:Wdr44 ^@ http://purl.uniprot.org/uniprot/I3M9F0 ^@ Subcellular Location Annotation ^@ trans-Golgi network http://togogenome.org/gene/43179:Bex3 ^@ http://purl.uniprot.org/uniprot/A0A287CXT3 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/43179:Pgk1 ^@ http://purl.uniprot.org/uniprot/I3LZI7 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/43179:Ids ^@ http://purl.uniprot.org/uniprot/I3MHX1 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/43179:Abcb7 ^@ http://purl.uniprot.org/uniprot/I3MH46 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/43179:LOC101955349 ^@ http://purl.uniprot.org/uniprot/I3N5X7 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/43179:Msl3 ^@ http://purl.uniprot.org/uniprot/A0A287D2M6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/43179:Utp14a ^@ http://purl.uniprot.org/uniprot/I3MBB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP14 family.|||nucleolus http://togogenome.org/gene/43179:LOC101964462 ^@ http://purl.uniprot.org/uniprot/I3NES9 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/43179:Ar ^@ http://purl.uniprot.org/uniprot/I3MT20 ^@ Similarity ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily. http://togogenome.org/gene/43179:Plp1 ^@ http://purl.uniprot.org/uniprot/I3M3J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/43179:Ndufb11 ^@ http://purl.uniprot.org/uniprot/I3N3N8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB11 subunit family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/43179:Cxcr3 ^@ http://purl.uniprot.org/uniprot/I3MC56 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Homomer. Forms heteromers with ACKR4.|||Membrane http://togogenome.org/gene/43179:Fam3a ^@ http://purl.uniprot.org/uniprot/I3MY52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/43179:Otc ^@ http://purl.uniprot.org/uniprot/I3M3I5 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily.|||Homotrimer. http://togogenome.org/gene/43179:Ubl4a ^@ http://purl.uniprot.org/uniprot/I3NES4 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/43179:Sh3bgrl ^@ http://purl.uniprot.org/uniprot/I3MKK4 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/43179:Gpm6b ^@ http://purl.uniprot.org/uniprot/A0A287D8N1|||http://purl.uniprot.org/uniprot/A0A287DDW8|||http://purl.uniprot.org/uniprot/A0A287DG39|||http://purl.uniprot.org/uniprot/I3M219 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/43179:LOC101955644 ^@ http://purl.uniprot.org/uniprot/I3LY16 ^@ Similarity ^@ Belongs to the NKAP family. http://togogenome.org/gene/43179:Bex4 ^@ http://purl.uniprot.org/uniprot/I3M3M2 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/43179:Prps1 ^@ http://purl.uniprot.org/uniprot/I3MA44 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/43179:Trappc2 ^@ http://purl.uniprot.org/uniprot/A0A287D123 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/43179:Mbtps2 ^@ http://purl.uniprot.org/uniprot/A0A287DFQ7 ^@ Similarity ^@ Belongs to the peptidase M50A family. http://togogenome.org/gene/43179:Mid1ip1 ^@ http://purl.uniprot.org/uniprot/I3N5H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/43179:Ca5b ^@ http://purl.uniprot.org/uniprot/I3MBP7 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/43179:Phex ^@ http://purl.uniprot.org/uniprot/I3M8M6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/43179:LOC101965899 ^@ http://purl.uniprot.org/uniprot/I3MYN5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/43179:Fundc1 ^@ http://purl.uniprot.org/uniprot/I3MVF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/43179:Tafazzin ^@ http://purl.uniprot.org/uniprot/A0A287CTI1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.|||Associates with multiple protein complexes.|||Belongs to the taffazin family.|||Mitochondrion inner membrane|||Mitochondrion outer membrane http://togogenome.org/gene/43179:Ace2 ^@ http://purl.uniprot.org/uniprot/I3M887 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M2 family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Cytoplasm|||Membrane|||Secreted|||cilium http://togogenome.org/gene/43179:Yipf6 ^@ http://purl.uniprot.org/uniprot/I3NAT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/43179:Ppef1 ^@ http://purl.uniprot.org/uniprot/I3N6F4 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/43179:Alg13 ^@ http://purl.uniprot.org/uniprot/A0A287CYM3|||http://purl.uniprot.org/uniprot/A0A287D4N9|||http://purl.uniprot.org/uniprot/I3M8J8 ^@ Similarity ^@ Belongs to the glycosyltransferase 28 family. http://togogenome.org/gene/43179:Acsl4 ^@ http://purl.uniprot.org/uniprot/I3M5T6 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/43179:Kif4a ^@ http://purl.uniprot.org/uniprot/I3MDW4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/43179:Dnaaf6 ^@ http://purl.uniprot.org/uniprot/I3LYR6 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/43179:ACI67_gp02 ^@ http://purl.uniprot.org/uniprot/A0A0U2CJS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 6 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion membrane http://togogenome.org/gene/43179:LOC101974254 ^@ http://purl.uniprot.org/uniprot/I3M2E8 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/43179:Txlng ^@ http://purl.uniprot.org/uniprot/I3M142 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/43179:Morf4l2 ^@ http://purl.uniprot.org/uniprot/I3NA99 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/43179:Bgn ^@ http://purl.uniprot.org/uniprot/I3MAY1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||May be involved in collagen fiber assembly.|||extracellular matrix http://togogenome.org/gene/43179:Steep1 ^@ http://purl.uniprot.org/uniprot/A0A287CYQ7 ^@ Similarity ^@ Belongs to the STEEP1 family. http://togogenome.org/gene/43179:Gpr173 ^@ http://purl.uniprot.org/uniprot/I3MSP5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/43179:Nlgn3 ^@ http://purl.uniprot.org/uniprot/A0A287D494|||http://purl.uniprot.org/uniprot/I3MQG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/43179:LOC106144991 ^@ http://purl.uniprot.org/uniprot/I3NC25 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/43179:Pdha1 ^@ http://purl.uniprot.org/uniprot/I3MPQ9 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. http://togogenome.org/gene/43179:Gjb1 ^@ http://purl.uniprot.org/uniprot/I3NEZ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with CNST.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/43179:Slc16a2 ^@ http://purl.uniprot.org/uniprot/I3MXZ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/43179:Ssr4 ^@ http://purl.uniprot.org/uniprot/I3MBB6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-delta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/43179:Smpx ^@ http://purl.uniprot.org/uniprot/I3M0M1 ^@ Function|||Similarity ^@ Belongs to the SMPX family.|||Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. http://togogenome.org/gene/43179:Tmem255a ^@ http://purl.uniprot.org/uniprot/A0A287CZX5|||http://purl.uniprot.org/uniprot/I3M061 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM255 family.|||Membrane http://togogenome.org/gene/43179:Cdk16 ^@ http://purl.uniprot.org/uniprot/A0A287CTJ4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/43179:Cask ^@ http://purl.uniprot.org/uniprot/I3N909 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/43179:Nap1l3 ^@ http://purl.uniprot.org/uniprot/A0A287DB88 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/43179:Mecp2 ^@ http://purl.uniprot.org/uniprot/A0A287CY93 ^@ Function|||Subcellular Location Annotation ^@ Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).|||Nucleus http://togogenome.org/gene/43179:Awat2 ^@ http://purl.uniprot.org/uniprot/I3LYE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/43179:Nap1l2 ^@ http://purl.uniprot.org/uniprot/I3MTA0 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/43179:LOC101973700 ^@ http://purl.uniprot.org/uniprot/Q5IR82 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane|||Monomer. Homodimer. Homotetramer.|||Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light. http://togogenome.org/gene/43179:ACI67_gp07 ^@ http://purl.uniprot.org/uniprot/A0A0U2CK93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane http://togogenome.org/gene/43179:Eif1ax ^@ http://purl.uniprot.org/uniprot/A0A287CZN7 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. http://togogenome.org/gene/43179:Gk ^@ http://purl.uniprot.org/uniprot/A0A287CVG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FGGY kinase family.|||Cytoplasm http://togogenome.org/gene/43179:Zic3 ^@ http://purl.uniprot.org/uniprot/I3N6B1 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/43179:Vamp7 ^@ http://purl.uniprot.org/uniprot/I3NDB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/43179:Usp11 ^@ http://purl.uniprot.org/uniprot/I3N6S8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Nucleus http://togogenome.org/gene/43179:Tmsb4x ^@ http://purl.uniprot.org/uniprot/A0A287CVS2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/43179:Uba1 ^@ http://purl.uniprot.org/uniprot/I3MGC1 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/43179:Cmc4 ^@ http://purl.uniprot.org/uniprot/I3NAL5 ^@ Similarity ^@ Belongs to the CMC4 family. http://togogenome.org/gene/43179:Mid1 ^@ http://purl.uniprot.org/uniprot/I3MKI3 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/43179:Ube2a ^@ http://purl.uniprot.org/uniprot/A0A287D4F9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/43179:Arhgef9 ^@ http://purl.uniprot.org/uniprot/A0A287CTU2|||http://purl.uniprot.org/uniprot/A0A287DB25 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.|||Cytoplasm|||Interacts with GPHN.|||Postsynaptic density http://togogenome.org/gene/43179:LOC101969868 ^@ http://purl.uniprot.org/uniprot/I3MD22 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/43179:Gabra3 ^@ http://purl.uniprot.org/uniprot/A0A287CSP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/43179:Pcyt1b ^@ http://purl.uniprot.org/uniprot/I3MNS1 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/43179:Cltrn ^@ http://purl.uniprot.org/uniprot/I3MC89 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/43179:Aifm1 ^@ http://purl.uniprot.org/uniprot/I3MBI5 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase family. http://togogenome.org/gene/43179:Tspan7 ^@ http://purl.uniprot.org/uniprot/I3MZ99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/43179:Tnmd ^@ http://purl.uniprot.org/uniprot/I3NFL5 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/43179:LOC101974816 ^@ http://purl.uniprot.org/uniprot/I3MXQ2 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/43179:ACI67_gp01 ^@ http://purl.uniprot.org/uniprot/U5IB27 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b family.|||Binds 2 heme groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.|||Membrane|||Mitochondrion inner membrane|||The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer. http://togogenome.org/gene/43179:Zc3h12b ^@ http://purl.uniprot.org/uniprot/I3N705 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/43179:Bex5 ^@ http://purl.uniprot.org/uniprot/I3NAB4 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/43179:Atp6ap2 ^@ http://purl.uniprot.org/uniprot/I3M634 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Lysosome membrane|||Membrane|||autophagosome membrane|||clathrin-coated vesicle membrane|||dendritic spine membrane|||synaptic vesicle membrane http://togogenome.org/gene/43179:Trex2 ^@ http://purl.uniprot.org/uniprot/I3N417 ^@ Similarity ^@ Belongs to the exonuclease superfamily. TREX family. http://togogenome.org/gene/43179:Rbm10 ^@ http://purl.uniprot.org/uniprot/A0A287CY21|||http://purl.uniprot.org/uniprot/A0A287D6N3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/43179:Fmr1 ^@ http://purl.uniprot.org/uniprot/A0A287CX40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMR1 family.|||Cell membrane|||Cytoplasmic ribonucleoprotein granule|||Membrane|||Perikaryon|||Presynaptic cell membrane|||Stress granule|||Synaptic cell membrane|||axon|||centromere|||dendrite|||dendritic spine|||filopodium tip|||growth cone|||neuron projection|||nucleolus|||perinuclear region|||synaptosome http://togogenome.org/gene/43179:Brcc3 ^@ http://purl.uniprot.org/uniprot/I3N470 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M67A family. BRCC36 subfamily.|||Binds 1 zinc ion per subunit.|||Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. In the BRISC complex, interacts directly with ABRAXAS2. Identified in a complex with ABRAXAS2 and NUMA1. The BRISC complex interacts with the CSN complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BABAM2 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. Interacts with BRCA1. Binds polyubiquitin. Interacts with PWWP2B. Interacts with HDAC1; this interaction is enhanced in the presence of PWWP2B.|||Cytoplasm|||Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.|||Nucleus|||spindle pole http://togogenome.org/gene/43179:Usp9x ^@ http://purl.uniprot.org/uniprot/I3LXD2 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/43179:Msn ^@ http://purl.uniprot.org/uniprot/I3MKT8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/43179:Chst7 ^@ http://purl.uniprot.org/uniprot/I3MX57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/43179:Pnck ^@ http://purl.uniprot.org/uniprot/I3MB26 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/43179:Mid2 ^@ http://purl.uniprot.org/uniprot/A0A287D3Y2 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/43179:Atp2b3 ^@ http://purl.uniprot.org/uniprot/A0A287DAQ0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/43179:Praf2 ^@ http://purl.uniprot.org/uniprot/I3ME07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/43179:ACI67_gp03 ^@ http://purl.uniprot.org/uniprot/A0A0U2CJZ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 5 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/43179:Ribc1 ^@ http://purl.uniprot.org/uniprot/I3M675 ^@ Similarity ^@ Belongs to the RIB43A family. http://togogenome.org/gene/43179:LOC101976085 ^@ http://purl.uniprot.org/uniprot/I3MWG8 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/43179:Alas2 ^@ http://purl.uniprot.org/uniprot/I3MAT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/43179:Cetn2 ^@ http://purl.uniprot.org/uniprot/I3N8D8 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/43179:Bcap31 ^@ http://purl.uniprot.org/uniprot/I3MB38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||Membrane|||Plays a role in the export of secreted proteins in the ER. http://togogenome.org/gene/43179:Pir ^@ http://purl.uniprot.org/uniprot/I3M831 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/43179:Gpc3 ^@ http://purl.uniprot.org/uniprot/I3MES6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/43179:Fgd1 ^@ http://purl.uniprot.org/uniprot/A0A287CZR1 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/43179:Flna ^@ http://purl.uniprot.org/uniprot/A0A287CWL8|||http://purl.uniprot.org/uniprot/I3M5H3 ^@ Similarity ^@ Belongs to the filamin family. http://togogenome.org/gene/43179:Egfl6 ^@ http://purl.uniprot.org/uniprot/I3MT28 ^@ Caution|||Similarity ^@ Belongs to the nephronectin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/43179:Timm8a ^@ http://purl.uniprot.org/uniprot/I3M4Q9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/43179:Zdhhc15 ^@ http://purl.uniprot.org/uniprot/A0A287D1Z8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/43179:Trpc5 ^@ http://purl.uniprot.org/uniprot/I3LYD3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/43179:Ndufa1 ^@ http://purl.uniprot.org/uniprot/I3N4A5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/43179:Tspan6 ^@ http://purl.uniprot.org/uniprot/I3MUR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/43179:Glra2 ^@ http://purl.uniprot.org/uniprot/I3M311 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/43179:Nr0b1 ^@ http://purl.uniprot.org/uniprot/I3NE22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus|||Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency. http://togogenome.org/gene/43179:Gspt2 ^@ http://purl.uniprot.org/uniprot/I3NGZ5 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. http://togogenome.org/gene/43179:Arr3 ^@ http://purl.uniprot.org/uniprot/Q5DRQ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the arrestin family.|||Homodimer; disulfide-linked in response to retinal illumination (By similarity). Interacts with CXCR4; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates the calcium ion mobilization activity of CXCR4 (By similarity).|||May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins (By similarity).|||Photoreceptor inner segment|||photoreceptor outer segment http://togogenome.org/gene/43179:Gpr119 ^@ http://purl.uniprot.org/uniprot/I3MPN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/43179:Abcd1 ^@ http://purl.uniprot.org/uniprot/I3MB54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/43179:ACI67_gp08 ^@ http://purl.uniprot.org/uniprot/A0A0U2CIH7|||http://purl.uniprot.org/uniprot/Q94UY0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase A chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with DNAJC30; interaction is direct (By similarity).|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/43179:Mospd1 ^@ http://purl.uniprot.org/uniprot/I3MB45 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/43179:Lpar4 ^@ http://purl.uniprot.org/uniprot/I3N939 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/43179:Hnrnph2 ^@ http://purl.uniprot.org/uniprot/I3N5Y0 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/43179:Igbp1 ^@ http://purl.uniprot.org/uniprot/I3MUE6 ^@ Similarity ^@ Belongs to the IGBP1/TAP42 family. http://togogenome.org/gene/43179:Ctps2 ^@ http://purl.uniprot.org/uniprot/I3LZ83 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/43179:Suv39h1 ^@ http://purl.uniprot.org/uniprot/I3MPK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.|||Nucleus|||centromere http://togogenome.org/gene/43179:Apln ^@ http://purl.uniprot.org/uniprot/A0A287D3D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the apelin family.|||extracellular space http://togogenome.org/gene/43179:Dusp9 ^@ http://purl.uniprot.org/uniprot/I3MB09 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/43179:Chm ^@ http://purl.uniprot.org/uniprot/I3NCP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. http://togogenome.org/gene/43179:Gdpd2 ^@ http://purl.uniprot.org/uniprot/I3M4B0 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/43179:Apex2 ^@ http://purl.uniprot.org/uniprot/I3NB59 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/43179:Prps2 ^@ http://purl.uniprot.org/uniprot/I3M773 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/43179:Dynlt3 ^@ http://purl.uniprot.org/uniprot/I3MXA2 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/43179:Upf3b ^@ http://purl.uniprot.org/uniprot/I3LXZ0 ^@ Similarity ^@ Belongs to the RENT3 family. http://togogenome.org/gene/43179:Smarca1 ^@ http://purl.uniprot.org/uniprot/A0A287CVX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.|||Nucleus http://togogenome.org/gene/43179:Naa10 ^@ http://purl.uniprot.org/uniprot/I3MF35 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/43179:Wnk3 ^@ http://purl.uniprot.org/uniprot/I3LWC3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/43179:LOC101967631 ^@ http://purl.uniprot.org/uniprot/I3NG02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/43179:ACI67_gp11 ^@ http://purl.uniprot.org/uniprot/A0A0U2CKE1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/43179:Tenm1 ^@ http://purl.uniprot.org/uniprot/A0A287D5J4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family. Teneurin subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/43179:Nexmif ^@ http://purl.uniprot.org/uniprot/A0A287CWN9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/43179:Slc35a2 ^@ http://purl.uniprot.org/uniprot/I3NC40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/43179:Foxo4 ^@ http://purl.uniprot.org/uniprot/I3NDY8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/43179:Zfx ^@ http://purl.uniprot.org/uniprot/I3M974 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/43179:Bclaf3 ^@ http://purl.uniprot.org/uniprot/A0A287DA98 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/43179:Plxna3 ^@ http://purl.uniprot.org/uniprot/I3M2C0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/43179:Srpx2 ^@ http://purl.uniprot.org/uniprot/I3M616 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/43179:Znf75d ^@ http://purl.uniprot.org/uniprot/I3MKF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/43179:Tsc22d3 ^@ http://purl.uniprot.org/uniprot/I3N4Q2 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/43179:Rp2 ^@ http://purl.uniprot.org/uniprot/I3MDP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.|||Belongs to the TBCC family.|||Cell membrane|||Membrane http://togogenome.org/gene/43179:Dipk2b ^@ http://purl.uniprot.org/uniprot/I3M073 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/43179:Mpp1 ^@ http://purl.uniprot.org/uniprot/I3LXX7 ^@ Function|||Subcellular Location Annotation ^@ Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.|||stereocilium http://togogenome.org/gene/43179:Itm2a ^@ http://purl.uniprot.org/uniprot/I3MEW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/43179:LOC101974547 ^@ http://purl.uniprot.org/uniprot/I3MGF2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/43179:Hprt1 ^@ http://purl.uniprot.org/uniprot/A0A287CU32 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/43179:Clic2 ^@ http://purl.uniprot.org/uniprot/I3N2E0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/43179:Amot ^@ http://purl.uniprot.org/uniprot/I3MY15 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/43179:Idh3g ^@ http://purl.uniprot.org/uniprot/I3MBB2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/43179:Rab9a ^@ http://purl.uniprot.org/uniprot/I3MXS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||phagosome membrane http://togogenome.org/gene/43179:Lancl3 ^@ http://purl.uniprot.org/uniprot/I3MJJ2 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/43179:Htr2c ^@ http://purl.uniprot.org/uniprot/I3N622 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/43179:Ftsj1 ^@ http://purl.uniprot.org/uniprot/I3N522 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.|||Cytoplasm|||Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. http://togogenome.org/gene/43179:Gdi1 ^@ http://purl.uniprot.org/uniprot/I3M479 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/43179:Vbp1 ^@ http://purl.uniprot.org/uniprot/I3M8C1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/43179:Nono ^@ http://purl.uniprot.org/uniprot/I3MQH7 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/43179:Apoo ^@ http://purl.uniprot.org/uniprot/I3LZP3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/43179:Kcne5 ^@ http://purl.uniprot.org/uniprot/I3MJ37 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/43179:Tsr2 ^@ http://purl.uniprot.org/uniprot/A0A287D7G0 ^@ Function|||Similarity ^@ Belongs to the TSR2 family.|||May be involved in 20S pre-rRNA processing. http://togogenome.org/gene/43179:Mcts1 ^@ http://purl.uniprot.org/uniprot/A0A287CYW1|||http://purl.uniprot.org/uniprot/I3MHF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCTS1 family.|||Cytoplasm http://togogenome.org/gene/43179:Brs3 ^@ http://purl.uniprot.org/uniprot/I3MJ93 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with C6orf89.|||Membrane http://togogenome.org/gene/43179:Rpl10 ^@ http://purl.uniprot.org/uniprot/I3MI39 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/43179:ACI67_gp05 ^@ http://purl.uniprot.org/uniprot/A0A0U2CK51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4L family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/43179:Hs6st2 ^@ http://purl.uniprot.org/uniprot/A0A287D1X5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/43179:G6pd ^@ http://purl.uniprot.org/uniprot/I3N7W5 ^@ Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. http://togogenome.org/gene/43179:Elk1 ^@ http://purl.uniprot.org/uniprot/I3MEI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/43179:Rragb ^@ http://purl.uniprot.org/uniprot/I3M4N1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome|||Lysosome membrane http://togogenome.org/gene/43179:Lamp2 ^@ http://purl.uniprot.org/uniprot/I3MS28 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/43179:LOC101967130 ^@ http://purl.uniprot.org/uniprot/A0A287CYV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIb family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/43179:Gria3 ^@ http://purl.uniprot.org/uniprot/A0A287D2U4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/43179:Slc7a3 ^@ http://purl.uniprot.org/uniprot/I3MMK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/43179:Cdx4 ^@ http://purl.uniprot.org/uniprot/I3NCH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/43179:Slc25a14 ^@ http://purl.uniprot.org/uniprot/A0A287CVL2|||http://purl.uniprot.org/uniprot/I3MPM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/43179:Tmsb15b ^@ http://purl.uniprot.org/uniprot/A0A287D9M4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/43179:LOC101959306 ^@ http://purl.uniprot.org/uniprot/I3MUH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/43179:Rap2c ^@ http://purl.uniprot.org/uniprot/I3N0C5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/43179:Slc10a3 ^@ http://purl.uniprot.org/uniprot/I3NDR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/43179:LOC101962175 ^@ http://purl.uniprot.org/uniprot/I3MYL1 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/43179:Pdk3 ^@ http://purl.uniprot.org/uniprot/I3MNR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/43179:ACI67_gp06 ^@ http://purl.uniprot.org/uniprot/A0A0U2CJJ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 3 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM186. Interacts with TMEM242.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.|||Mitochondrion membrane http://togogenome.org/gene/43179:Cnksr2 ^@ http://purl.uniprot.org/uniprot/I3MH95 ^@ Similarity ^@ Belongs to the CNKSR family. http://togogenome.org/gene/43179:LOC101974845 ^@ http://purl.uniprot.org/uniprot/A0A287DA66 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/43179:Bcorl1 ^@ http://purl.uniprot.org/uniprot/I3NEX3 ^@ Similarity ^@ Belongs to the BCOR family. http://togogenome.org/gene/43179:Kdm6a ^@ http://purl.uniprot.org/uniprot/A0A287D8K1|||http://purl.uniprot.org/uniprot/I3LYW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTX family.|||Nucleus http://togogenome.org/gene/43179:Smc1a ^@ http://purl.uniprot.org/uniprot/I3M666 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/43179:Tfe3 ^@ http://purl.uniprot.org/uniprot/A0A287DDQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/43179:Plp2 ^@ http://purl.uniprot.org/uniprot/I3MN84 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/43179:Rbbp7 ^@ http://purl.uniprot.org/uniprot/I3M161 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/43179:Cldn2 ^@ http://purl.uniprot.org/uniprot/I3N275 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/43179:F9 ^@ http://purl.uniprot.org/uniprot/I3MG53 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/43179:Maob ^@ http://purl.uniprot.org/uniprot/I3M590 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/43179:Htatsf1 ^@ http://purl.uniprot.org/uniprot/A0A287D7C1 ^@ Similarity ^@ Belongs to the HTATSF1 family. http://togogenome.org/gene/43179:Mtmr8 ^@ http://purl.uniprot.org/uniprot/I3N578 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/43179:Atrx ^@ http://purl.uniprot.org/uniprot/A0A287CYU5 ^@ Subcellular Location Annotation ^@ Nucleus|||telomere http://togogenome.org/gene/43179:Spin4 ^@ http://purl.uniprot.org/uniprot/I3MVG9 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/43179:Xk ^@ http://purl.uniprot.org/uniprot/I3N3P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/43179:Zdhhc9 ^@ http://purl.uniprot.org/uniprot/I3N9M6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/43179:Rps6ka6 ^@ http://purl.uniprot.org/uniprot/A0A287CWW4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/43179:Asb11 ^@ http://purl.uniprot.org/uniprot/A0A287DCW3 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/43179:Dnase1l1 ^@ http://purl.uniprot.org/uniprot/I3MI44 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/43179:Actrt1 ^@ http://purl.uniprot.org/uniprot/I3N424 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/43179:LOC101955809 ^@ http://purl.uniprot.org/uniprot/I3MVA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/43179:Pou3f4 ^@ http://purl.uniprot.org/uniprot/I3MX42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-3 subfamily.|||Nucleus http://togogenome.org/gene/43179:Znf449 ^@ http://purl.uniprot.org/uniprot/I3MU45 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/43179:Mtm1 ^@ http://purl.uniprot.org/uniprot/A0A287CWR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/43179:Rps6ka3 ^@ http://purl.uniprot.org/uniprot/I3MFL8|||http://purl.uniprot.org/uniprot/I3MVR1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/43179:Rgn ^@ http://purl.uniprot.org/uniprot/I3MMS4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/43179:Porcn ^@ http://purl.uniprot.org/uniprot/I3LXV4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/43179:LOC101967565 ^@ http://purl.uniprot.org/uniprot/I3N3L1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/43179:Awat1 ^@ http://purl.uniprot.org/uniprot/I3MHD2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/43179:Aff2 ^@ http://purl.uniprot.org/uniprot/A0A287DA17|||http://purl.uniprot.org/uniprot/I3M4X8 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/43179:ACI67_gp09 ^@ http://purl.uniprot.org/uniprot/A0A0U2CJK9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase protein 8 family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion membrane http://togogenome.org/gene/43179:Hsd17b10 ^@ http://purl.uniprot.org/uniprot/I3M679 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/43179:Gpc4 ^@ http://purl.uniprot.org/uniprot/I3MKW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/43179:Prickle3 ^@ http://purl.uniprot.org/uniprot/I3MN81 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/43179:Gpr34 ^@ http://purl.uniprot.org/uniprot/I3LYT6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Orphan receptor. http://togogenome.org/gene/43179:LOC101977951 ^@ http://purl.uniprot.org/uniprot/I3MS85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/43179:Ogt ^@ http://purl.uniprot.org/uniprot/I3MIG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.|||Cell projection|||Mitochondrion membrane http://togogenome.org/gene/43179:Uxt ^@ http://purl.uniprot.org/uniprot/I3MEI9 ^@ Similarity ^@ Belongs to the UXT family. http://togogenome.org/gene/43179:Mtmr1 ^@ http://purl.uniprot.org/uniprot/I3MQE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/43179:Amer1 ^@ http://purl.uniprot.org/uniprot/I3MMD2 ^@ Similarity ^@ Belongs to the Amer family. http://togogenome.org/gene/43179:Pin4 ^@ http://purl.uniprot.org/uniprot/I3MPK8 ^@ Similarity ^@ Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily. http://togogenome.org/gene/43179:Cd40lg ^@ http://purl.uniprot.org/uniprot/I3M7D0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.|||Belongs to the tumor necrosis factor family.|||Cell surface|||Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.|||Homotrimer. http://togogenome.org/gene/43179:Thoc2 ^@ http://purl.uniprot.org/uniprot/I3NFC4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THOC2 family.|||Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.|||Nucleus http://togogenome.org/gene/43179:LOC101973251 ^@ http://purl.uniprot.org/uniprot/I3MV85 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/43179:Grpr ^@ http://purl.uniprot.org/uniprot/I3NBR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/43179:Sh2d1a ^@ http://purl.uniprot.org/uniprot/I3MM40 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. http://togogenome.org/gene/43179:Pabir2 ^@ http://purl.uniprot.org/uniprot/A0A287CXT2|||http://purl.uniprot.org/uniprot/A0A287D460|||http://purl.uniprot.org/uniprot/I3M7J5 ^@ Similarity ^@ Belongs to the FAM122 family. http://togogenome.org/gene/43179:ACI67_gp13 ^@ http://purl.uniprot.org/uniprot/A0A0U2CJR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 1 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/43179:Hmgb3 ^@ http://purl.uniprot.org/uniprot/I3N9R6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/43179:Slc25a5 ^@ http://purl.uniprot.org/uniprot/I3NHB6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/43179:LOC101971758 ^@ http://purl.uniprot.org/uniprot/I3MF53 ^@ Similarity ^@ Belongs to the N-acylglucosamine 2-epimerase family. http://togogenome.org/gene/43179:Nox1 ^@ http://purl.uniprot.org/uniprot/A0A287CWA3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/43179:Il13ra2 ^@ http://purl.uniprot.org/uniprot/I3MR89 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/43179:Apool ^@ http://purl.uniprot.org/uniprot/I3M5E5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/43179:Efnb1 ^@ http://purl.uniprot.org/uniprot/I3N370 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/43179:Phka1 ^@ http://purl.uniprot.org/uniprot/A0A287D3U1|||http://purl.uniprot.org/uniprot/A0A287D8H3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. http://togogenome.org/gene/43179:Maoa ^@ http://purl.uniprot.org/uniprot/I3M574 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/43179:Atp1b4 ^@ http://purl.uniprot.org/uniprot/I3M065 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/43179:LOC101964999 ^@ http://purl.uniprot.org/uniprot/I3LXV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/43179:Srpx ^@ http://purl.uniprot.org/uniprot/A0A287DEL2|||http://purl.uniprot.org/uniprot/I3MAD5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/43179:Atg4a ^@ http://purl.uniprot.org/uniprot/I3M307 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/43179:Gla ^@ http://purl.uniprot.org/uniprot/I3M4U4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/43179:Mpc1l ^@ http://purl.uniprot.org/uniprot/I3NF13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/43179:Rbm3 ^@ http://purl.uniprot.org/uniprot/I3MY48 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/43179:LOC101958683 ^@ http://purl.uniprot.org/uniprot/I3NEB3 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/43179:Kdm5c ^@ http://purl.uniprot.org/uniprot/I3LY73 ^@ Similarity ^@ Belongs to the JARID1 histone demethylase family. http://togogenome.org/gene/43179:ACI67_gp04 ^@ http://purl.uniprot.org/uniprot/A0A0U2CJ30 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/43179:Mtcp1 ^@ http://purl.uniprot.org/uniprot/I3M4U7 ^@ Similarity ^@ Belongs to the TCL1 family. http://togogenome.org/gene/43179:Syn1 ^@ http://purl.uniprot.org/uniprot/I3MWD7 ^@ Similarity ^@ Belongs to the synapsin family. http://togogenome.org/gene/43179:Heph ^@ http://purl.uniprot.org/uniprot/I3MPJ1 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/43179:LOC101967701 ^@ http://purl.uniprot.org/uniprot/I3MA89 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/43179:LOC101963529 ^@ http://purl.uniprot.org/uniprot/I3LW16 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/43179:Atp6ap1 ^@ http://purl.uniprot.org/uniprot/A0A287D5Z8 ^@ Similarity ^@ Belongs to the vacuolar ATPase subunit S1 family. http://togogenome.org/gene/43179:LOC101978619 ^@ http://purl.uniprot.org/uniprot/I3MM59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/43179:Araf ^@ http://purl.uniprot.org/uniprot/I3M383 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/43179:Gata1 ^@ http://purl.uniprot.org/uniprot/I3NB53 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/43179:Cited1 ^@ http://purl.uniprot.org/uniprot/I3MBL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CITED family.|||Nucleus http://togogenome.org/gene/43179:Hcfc1 ^@ http://purl.uniprot.org/uniprot/I3N3V9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/43179:Il13ra1 ^@ http://purl.uniprot.org/uniprot/I3NHG8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/43179:Slc25a43 ^@ http://purl.uniprot.org/uniprot/I3M503 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane