http://togogenome.org/gene/4950:TDEL_0A02210 ^@ http://purl.uniprot.org/uniprot/G8ZLQ9 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/4950:TDEL_0B02930 ^@ http://purl.uniprot.org/uniprot/G8ZP78 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/4950:TDEL_0F02010 ^@ http://purl.uniprot.org/uniprot/G8ZWL8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion inner membrane|||Monomer. http://togogenome.org/gene/4950:TDEL_0C06300 ^@ http://purl.uniprot.org/uniprot/G8ZQN2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP3 family.|||Endoplasmic reticulum membrane|||Involved in the lipid remodeling steps of GPI-anchor maturation.|||Membrane http://togogenome.org/gene/4950:TDEL_0B01800 ^@ http://purl.uniprot.org/uniprot/G8ZNW5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0A06630 ^@ http://purl.uniprot.org/uniprot/G8ZN01 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Cytoplasm|||Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway. The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. http://togogenome.org/gene/4950:TDEL_0D02110 ^@ http://purl.uniprot.org/uniprot/G8ZT51 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/4950:TDEL_0G03720 ^@ http://purl.uniprot.org/uniprot/G8ZXX2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/4950:TDEL_0G00880 ^@ http://purl.uniprot.org/uniprot/G8ZYI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1A family.|||Nucleus|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. http://togogenome.org/gene/4950:TDEL_0B06520 ^@ http://purl.uniprot.org/uniprot/G8ZQ87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPC42 family.|||Forms a polymeric layer at the periphery of the spindle pole body (SPB) central plaque which has an essential function during SPB duplication and may facilitate attachment of the SPB to the nuclear membrane.|||spindle pole body http://togogenome.org/gene/4950:TDEL_0G01010 ^@ http://purl.uniprot.org/uniprot/G8ZYJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B04220 ^@ http://purl.uniprot.org/uniprot/G8ZPK7 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/4950:TDEL_0H02470 ^@ http://purl.uniprot.org/uniprot/G8ZZR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane magnesium transporter (TC 1.A.67) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A05430 ^@ http://purl.uniprot.org/uniprot/G8ZMN1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/4950:TDEL_0G04420 ^@ http://purl.uniprot.org/uniprot/G8ZY42 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0G04010 ^@ http://purl.uniprot.org/uniprot/G8ZY01 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D00880 ^@ http://purl.uniprot.org/uniprot/G8ZSS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/4950:TDEL_0H01360 ^@ http://purl.uniprot.org/uniprot/G8ZZF1 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/4950:TDEL_0H01110 ^@ http://purl.uniprot.org/uniprot/G8ZZC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.|||Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.|||Nucleus http://togogenome.org/gene/4950:TDEL_0F01260 ^@ http://purl.uniprot.org/uniprot/G8ZWE3 ^@ Similarity ^@ Belongs to the synaptojanin family.|||In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. http://togogenome.org/gene/4950:TDEL_0G02980 ^@ http://purl.uniprot.org/uniprot/G8ZXP8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NUR1 family.|||Member of a perinuclear network that controls recombination at multiple loci to maintain genome stability. Required for rDNA repeat stability.|||Membrane|||Nucleus membrane http://togogenome.org/gene/4950:TDEL_0A06070 ^@ http://purl.uniprot.org/uniprot/G8ZMU5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D02780 ^@ http://purl.uniprot.org/uniprot/G8ZTB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 48 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D04540 ^@ http://purl.uniprot.org/uniprot/G8ZTU4 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0B05070 ^@ http://purl.uniprot.org/uniprot/G8ZPU2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0E04910 ^@ http://purl.uniprot.org/uniprot/G8ZVU0 ^@ Similarity ^@ Belongs to the IlvD/Edd family. http://togogenome.org/gene/4950:TDEL_0E00300 ^@ http://purl.uniprot.org/uniprot/G8ZUH9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0E01490 ^@ http://purl.uniprot.org/uniprot/G8ZUU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KRE9/KNH1 family.|||Involved in cell wall beta(1->6) glucan synthesis.|||cell wall http://togogenome.org/gene/4950:TDEL_0E02480 ^@ http://purl.uniprot.org/uniprot/G8ZV47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STE12 transcription factor family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A07330 ^@ http://purl.uniprot.org/uniprot/G8ZN71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M76 family.|||Has a dual role in the assembly of mitochondrial ATPase.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0A06440 ^@ http://purl.uniprot.org/uniprot/G8ZMY2 ^@ Similarity ^@ Belongs to the NXF family. http://togogenome.org/gene/4950:TDEL_0H02650 ^@ http://purl.uniprot.org/uniprot/G8ZZT0 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/4950:TDEL_0A04990 ^@ http://purl.uniprot.org/uniprot/G8ZMI7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/4950:TDEL_0B06350 ^@ http://purl.uniprot.org/uniprot/G8ZQ70 ^@ Function|||Similarity ^@ Belongs to the UDPGP type 1 family.|||Plays a central role as a glucosyl donor in cellular metabolic pathways. http://togogenome.org/gene/4950:TDEL_0F01690 ^@ http://purl.uniprot.org/uniprot/G8ZWI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0H00340 ^@ http://purl.uniprot.org/uniprot/G8ZZ49 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Cytoplasm|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0C00380 ^@ http://purl.uniprot.org/uniprot/G8ZQY5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 14 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D00770 ^@ http://purl.uniprot.org/uniprot/G8ZSR7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/4950:TDEL_0D03320 ^@ http://purl.uniprot.org/uniprot/G8ZTH2 ^@ Similarity|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Homodimer. http://togogenome.org/gene/4950:TDEL_0G02690 ^@ http://purl.uniprot.org/uniprot/G8ZZ11 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0C03900 ^@ http://purl.uniprot.org/uniprot/G8ZRY7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the DPH1/DPH2 family. DPH1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. http://togogenome.org/gene/4950:TDEL_0A01410 ^@ http://purl.uniprot.org/uniprot/G8ZLH9 ^@ Similarity ^@ Belongs to the RRP1 family. http://togogenome.org/gene/4950:TDEL_0A03870 ^@ http://purl.uniprot.org/uniprot/G8ZM75 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0E03210 ^@ http://purl.uniprot.org/uniprot/G8ZVC0 ^@ Function|||Similarity ^@ Belongs to the RRF family.|||Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria. http://togogenome.org/gene/4950:TDEL_0E03120 ^@ http://purl.uniprot.org/uniprot/G8ZVB1 ^@ Similarity ^@ Belongs to the ATPase delta chain family. http://togogenome.org/gene/4950:TDEL_0C02820 ^@ http://purl.uniprot.org/uniprot/G8ZRM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid/polyamine transporter 2 family.|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0E03380 ^@ http://purl.uniprot.org/uniprot/G8ZVD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase PH family.|||Cytoplasm|||nucleolus http://togogenome.org/gene/4950:TDEL_0F00870 ^@ http://purl.uniprot.org/uniprot/G8ZWA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0B00580 ^@ http://purl.uniprot.org/uniprot/G8ZNJ3 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||This promotes the activity of RNA polymerase II. http://togogenome.org/gene/4950:TDEL_0H04260 ^@ http://purl.uniprot.org/uniprot/G9A091 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/4950:TDEL_0D04070 ^@ http://purl.uniprot.org/uniprot/G8ZTP7 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/4950:TDEL_0A00150 ^@ http://purl.uniprot.org/uniprot/G8ZL53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0E02060 ^@ http://purl.uniprot.org/uniprot/G8ZV05 ^@ Similarity ^@ Belongs to the BCP1 family. http://togogenome.org/gene/4950:TDEL_0A07040 ^@ http://purl.uniprot.org/uniprot/G8ZN42 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0F01180 ^@ http://purl.uniprot.org/uniprot/G8ZWD5 ^@ Similarity ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family. http://togogenome.org/gene/4950:TDEL_0C03790 ^@ http://purl.uniprot.org/uniprot/G8ZRX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP2 family.|||nucleolus http://togogenome.org/gene/4950:TDEL_0H01420 ^@ http://purl.uniprot.org/uniprot/G8ZZF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Endomembrane system|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0C03060 ^@ http://purl.uniprot.org/uniprot/G8ZRQ3 ^@ Similarity ^@ Belongs to the WD repeat L(2)GL family. http://togogenome.org/gene/4950:TDEL_0D05400 ^@ http://purl.uniprot.org/uniprot/G8ZU30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0C05360 ^@ http://purl.uniprot.org/uniprot/G8ZSD3 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. http://togogenome.org/gene/4950:TDEL_0C04800 ^@ http://purl.uniprot.org/uniprot/G8ZS77 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/4950:TDEL_0G04860 ^@ http://purl.uniprot.org/uniprot/G8ZY86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0G00110 ^@ http://purl.uniprot.org/uniprot/G8ZYA3 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/4950:TDEL_0H00720 ^@ http://purl.uniprot.org/uniprot/G8ZZ87 ^@ Function|||Similarity ^@ ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.|||Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/4950:TDEL_0H02400 ^@ http://purl.uniprot.org/uniprot/G8ZZQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG28 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0A01360 ^@ http://purl.uniprot.org/uniprot/G8ZLH4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0A04410 ^@ http://purl.uniprot.org/uniprot/G8ZMC9 ^@ Similarity ^@ Belongs to the UPL family. TOM1/PTR1 subfamily. http://togogenome.org/gene/4950:TDEL_0C01230 ^@ http://purl.uniprot.org/uniprot/G8ZR70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin interacting component (NIC) family.|||nuclear pore complex http://togogenome.org/gene/4950:TDEL_0F00250 ^@ http://purl.uniprot.org/uniprot/G8ZW42 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/4950:TDEL_0G03450 ^@ http://purl.uniprot.org/uniprot/G8ZXU5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLX1 family.|||Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.|||Forms a heterodimer with SLX4.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/4950:TDEL_0H02060 ^@ http://purl.uniprot.org/uniprot/G8ZZM1 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/4950:TDEL_0B03020 ^@ http://purl.uniprot.org/uniprot/G8ZP87 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/4950:TDEL_0F01480 ^@ http://purl.uniprot.org/uniprot/G8ZWG5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.|||Belongs to the adaptor complexes large subunit family.|||coated pit http://togogenome.org/gene/4950:TDEL_0B02900 ^@ http://purl.uniprot.org/uniprot/G8ZP75 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0F02410 ^@ http://purl.uniprot.org/uniprot/G8ZWQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat HIR1 family.|||Nucleus|||Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle. http://togogenome.org/gene/4950:TDEL_0C06220 ^@ http://purl.uniprot.org/uniprot/G8ZQM4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0B05860 ^@ http://purl.uniprot.org/uniprot/G8ZQ21 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/4950:TDEL_0C06700 ^@ http://purl.uniprot.org/uniprot/G8ZQS2 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/4950:TDEL_0A03140 ^@ http://purl.uniprot.org/uniprot/G8ZM02 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0F03000 ^@ http://purl.uniprot.org/uniprot/G8ZWW7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/4950:TDEL_0B06810 ^@ http://purl.uniprot.org/uniprot/G8ZQB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DASH complex ASK1 family.|||Nucleus|||kinetochore|||spindle http://togogenome.org/gene/4950:TDEL_0C05520 ^@ http://purl.uniprot.org/uniprot/G8ZSE9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0C06790 ^@ http://purl.uniprot.org/uniprot/G8ZQT1 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||GTPase-activating protein for the ADP ribosylation factor family. http://togogenome.org/gene/4950:TDEL_0B06070 ^@ http://purl.uniprot.org/uniprot/G8ZQ42 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0C06450 ^@ http://purl.uniprot.org/uniprot/G8ZQP7 ^@ Similarity ^@ Belongs to the phosphatidylethanolamine-binding protein family. http://togogenome.org/gene/4950:TDEL_0F04280 ^@ http://purl.uniprot.org/uniprot/G8ZX95 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0G01350 ^@ http://purl.uniprot.org/uniprot/G8ZYM7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/4950:TDEL_0D03260 ^@ http://purl.uniprot.org/uniprot/G8ZTG6 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/4950:TDEL_0H04520 ^@ http://purl.uniprot.org/uniprot/G9A0B7 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome.|||Nucleus|||Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends. http://togogenome.org/gene/4950:TDEL_0F02220 ^@ http://purl.uniprot.org/uniprot/G8ZWN9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0F04130 ^@ http://purl.uniprot.org/uniprot/G8ZX80 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/4950:TDEL_0F01420 ^@ http://purl.uniprot.org/uniprot/G8ZWF9 ^@ Similarity ^@ Belongs to the ribose 5-phosphate isomerase family. http://togogenome.org/gene/4950:TDEL_0D02080 ^@ http://purl.uniprot.org/uniprot/G8ZT48 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic12 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0E01010 ^@ http://purl.uniprot.org/uniprot/G8ZUQ0 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. http://togogenome.org/gene/4950:TDEL_0H04510 ^@ http://purl.uniprot.org/uniprot/G9A0B6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0H00600 ^@ http://purl.uniprot.org/uniprot/G8ZZ75 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0F02250 ^@ http://purl.uniprot.org/uniprot/G8ZWP2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.|||Belongs to the replication factor A protein 1 family.|||Component of the heterotrimeric canonical replication protein A complex (RPA).|||Nucleus http://togogenome.org/gene/4950:TDEL_0E05630 ^@ http://purl.uniprot.org/uniprot/G8ZW12 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Component of the GSE complex.|||GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions. http://togogenome.org/gene/4950:TDEL_0E01620 ^@ http://purl.uniprot.org/uniprot/G8ZUW1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0B06230 ^@ http://purl.uniprot.org/uniprot/G8ZQ58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0C05540 ^@ http://purl.uniprot.org/uniprot/G8ZSF1 ^@ Subunit ^@ The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. http://togogenome.org/gene/4950:TDEL_0E03770 ^@ http://purl.uniprot.org/uniprot/G8ZVH6 ^@ Similarity ^@ Belongs to the LTV1 family. http://togogenome.org/gene/4950:TDEL_0C02090 ^@ http://purl.uniprot.org/uniprot/G8ZRF6 ^@ Function|||Similarity ^@ Belongs to the PNP/MTAP phosphorylase family.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/4950:TDEL_0A01750 ^@ http://purl.uniprot.org/uniprot/G8ZLL3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/4950:TDEL_0A06200 ^@ http://purl.uniprot.org/uniprot/G8ZMV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTPA-type PPIase family.|||Cytoplasm|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/4950:TDEL_0E05060 ^@ http://purl.uniprot.org/uniprot/G8ZVV5 ^@ Similarity ^@ Belongs to the TOG/XMAP215 family. http://togogenome.org/gene/4950:TDEL_0F01610 ^@ http://purl.uniprot.org/uniprot/G8ZWH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0F05240 ^@ http://purl.uniprot.org/uniprot/G8ZXJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A03150 ^@ http://purl.uniprot.org/uniprot/G8ZM03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNT transporter (TC 2.A.44) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0H00210 ^@ http://purl.uniprot.org/uniprot/G8ZZ36 ^@ Similarity ^@ Belongs to the BMT family. http://togogenome.org/gene/4950:TDEL_0G03340 ^@ http://purl.uniprot.org/uniprot/G8ZXT4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0E01780 ^@ http://purl.uniprot.org/uniprot/G8ZUX7 ^@ Similarity ^@ Belongs to the sirtuin family. Class I subfamily. http://togogenome.org/gene/4950:TDEL_0A07720 ^@ http://purl.uniprot.org/uniprot/G8ZNB0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0B03380 ^@ http://purl.uniprot.org/uniprot/G8ZPC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E04490 ^@ http://purl.uniprot.org/uniprot/G8ZVP8 ^@ Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family. http://togogenome.org/gene/4950:TDEL_0D00380 ^@ http://purl.uniprot.org/uniprot/G8ZSM8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/4950:TDEL_0E04950 ^@ http://purl.uniprot.org/uniprot/G8ZVU4 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.|||In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. http://togogenome.org/gene/4950:TDEL_0E03640 ^@ http://purl.uniprot.org/uniprot/G8ZVG3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. http://togogenome.org/gene/4950:TDEL_0G00910 ^@ http://purl.uniprot.org/uniprot/G8ZYI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.|||Belongs to the NMD3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0D05170 ^@ http://purl.uniprot.org/uniprot/G8ZU07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutS family.|||Component of the post-replicative DNA mismatch repair system (MMR).|||Nucleus http://togogenome.org/gene/4950:TDEL_0C03130 ^@ http://purl.uniprot.org/uniprot/G8ZRR0 ^@ Similarity|||Subunit ^@ Belongs to the glutamine synthetase family.|||Homooctamer. http://togogenome.org/gene/4950:TDEL_0A06240 ^@ http://purl.uniprot.org/uniprot/G8ZMW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||cytoskeleton http://togogenome.org/gene/4950:TDEL_0A02830 ^@ http://purl.uniprot.org/uniprot/G8ZLX1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0G03240 ^@ http://purl.uniprot.org/uniprot/G8ZXS4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/4950:TDEL_0B00520 ^@ http://purl.uniprot.org/uniprot/G8ZNI7 ^@ Function|||Similarity ^@ Belongs to the PIGL family.|||Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol. http://togogenome.org/gene/4950:TDEL_0B04020 ^@ http://purl.uniprot.org/uniprot/G8ZPI7 ^@ Similarity ^@ Belongs to the ERT1/acuK family. http://togogenome.org/gene/4950:TDEL_0H01230 ^@ http://purl.uniprot.org/uniprot/G8ZZD8 ^@ Similarity ^@ Belongs to the SUN family. http://togogenome.org/gene/4950:TDEL_0F00480 ^@ http://purl.uniprot.org/uniprot/G8ZW65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0G02190 ^@ http://purl.uniprot.org/uniprot/G8ZYW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NFX1 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A02790 ^@ http://purl.uniprot.org/uniprot/G8ZLW7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/4950:TDEL_0F05000 ^@ http://purl.uniprot.org/uniprot/G8ZXG7 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/4950:TDEL_0E01990 ^@ http://purl.uniprot.org/uniprot/G8ZUZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B03550 ^@ http://purl.uniprot.org/uniprot/G8ZPE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF7 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D00940 ^@ http://purl.uniprot.org/uniprot/G8ZST4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0A03850 ^@ http://purl.uniprot.org/uniprot/G8ZM73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAK10 family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0B05470 ^@ http://purl.uniprot.org/uniprot/G8ZPY2 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/4950:TDEL_0F03760 ^@ http://purl.uniprot.org/uniprot/G8ZX43 ^@ Similarity ^@ Belongs to the RecA family. DMC1 subfamily. http://togogenome.org/gene/4950:TDEL_0D04900 ^@ http://purl.uniprot.org/uniprot/G8ZTY0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/4950:TDEL_0D04420 ^@ http://purl.uniprot.org/uniprot/G8ZTT2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/4950:TDEL_0B01770 ^@ http://purl.uniprot.org/uniprot/G8ZNW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D01530 ^@ http://purl.uniprot.org/uniprot/G8ZSZ3 ^@ Similarity ^@ Belongs to the IML2 family. http://togogenome.org/gene/4950:TDEL_0F01350 ^@ http://purl.uniprot.org/uniprot/G8ZWF2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAD/OST2 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/4950:TDEL_0A02110 ^@ http://purl.uniprot.org/uniprot/G8ZLP9 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/4950:TDEL_0A05170 ^@ http://purl.uniprot.org/uniprot/G8ZMK5 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/4950:TDEL_0H01020 ^@ http://purl.uniprot.org/uniprot/G8ZZB7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0C01440 ^@ http://purl.uniprot.org/uniprot/G8ZR91 ^@ Similarity ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. http://togogenome.org/gene/4950:TDEL_0A04580 ^@ http://purl.uniprot.org/uniprot/G8ZME6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. http://togogenome.org/gene/4950:TDEL_0D01880 ^@ http://purl.uniprot.org/uniprot/G8ZT28 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/4950:TDEL_0B05610 ^@ http://purl.uniprot.org/uniprot/G8ZPZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EDC3 family.|||P-body http://togogenome.org/gene/4950:TDEL_0F01460 ^@ http://purl.uniprot.org/uniprot/G8ZWG3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/4950:TDEL_0B06090 ^@ http://purl.uniprot.org/uniprot/G8ZQ44 ^@ Similarity ^@ Belongs to the acetolactate synthase small subunit family. http://togogenome.org/gene/4950:TDEL_0D05760 ^@ http://purl.uniprot.org/uniprot/G8ZU66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SKN1/KRE6 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D04020 ^@ http://purl.uniprot.org/uniprot/G8ZTP2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0G00860 ^@ http://purl.uniprot.org/uniprot/G8ZYH8 ^@ Similarity ^@ Belongs to the enolase family. http://togogenome.org/gene/4950:TDEL_0H00860 ^@ http://purl.uniprot.org/uniprot/G8ZZA1 ^@ Cofactor|||Similarity ^@ Belongs to the radical SAM superfamily. Biotin synthase family.|||Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/4950:TDEL_0F03480 ^@ http://purl.uniprot.org/uniprot/G8ZX15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane|||Peroxisome membrane http://togogenome.org/gene/4950:TDEL_0F03710 ^@ http://purl.uniprot.org/uniprot/G8ZX38 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0C01350 ^@ http://purl.uniprot.org/uniprot/G8ZR82 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0A01330 ^@ http://purl.uniprot.org/uniprot/G8ZLH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/4950:TDEL_0H02200 ^@ http://purl.uniprot.org/uniprot/G8ZZN5 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/4950:TDEL_0F01020 ^@ http://purl.uniprot.org/uniprot/G8ZWB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRG family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G03650 ^@ http://purl.uniprot.org/uniprot/G8ZXW5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Expected to bind 2 Fe(2+) ions per subunit.|||Membrane|||Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. http://togogenome.org/gene/4950:TDEL_0E02100 ^@ http://purl.uniprot.org/uniprot/G8ZV09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPC110 family.|||Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication. Potential role in cross-linking filaments or anchoring other molecules. It is essential for growth.|||Nucleus|||spindle pole body http://togogenome.org/gene/4950:TDEL_0F03310 ^@ http://purl.uniprot.org/uniprot/G8ZWZ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 18 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A04110 ^@ http://purl.uniprot.org/uniprot/G8ZM99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-Z subfamily.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0D02340 ^@ http://purl.uniprot.org/uniprot/G8ZT74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0F03720 ^@ http://purl.uniprot.org/uniprot/G8ZX39 ^@ Function|||Similarity ^@ Belongs to the peptidase M24 family.|||Probable metalloprotease involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm. http://togogenome.org/gene/4950:TDEL_0C01490 ^@ http://purl.uniprot.org/uniprot/G8ZR96 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/4950:TDEL_0A06220 ^@ http://purl.uniprot.org/uniprot/G8ZMW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.|||Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E02040 ^@ http://purl.uniprot.org/uniprot/G8ZV03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A06530 ^@ http://purl.uniprot.org/uniprot/G8ZMZ1 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/4950:TDEL_0C01590 ^@ http://purl.uniprot.org/uniprot/G8ZRA6 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/4950:TDEL_0B01240 ^@ http://purl.uniprot.org/uniprot/G8ZNQ9 ^@ Similarity ^@ Belongs to the glycosyltransferase 32 family. http://togogenome.org/gene/4950:TDEL_0B00160 ^@ http://purl.uniprot.org/uniprot/G8ZNF1 ^@ Similarity ^@ Belongs to the MNN1/MNT family. http://togogenome.org/gene/4950:TDEL_0G03710 ^@ http://purl.uniprot.org/uniprot/G8ZXX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C04230 ^@ http://purl.uniprot.org/uniprot/G8ZS20 ^@ Similarity ^@ Belongs to the END3 family. http://togogenome.org/gene/4950:TDEL_0C07010 ^@ http://purl.uniprot.org/uniprot/G8ZQV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MATALPHA1 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A05600 ^@ http://purl.uniprot.org/uniprot/G8ZMP8 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/4950:TDEL_0D04720 ^@ http://purl.uniprot.org/uniprot/G8ZTW2 ^@ Similarity ^@ Belongs to the SF3A2 family. http://togogenome.org/gene/4950:TDEL_0C06480 ^@ http://purl.uniprot.org/uniprot/G8ZQQ0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome.|||Nucleus|||Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends. http://togogenome.org/gene/4950:TDEL_0F02880 ^@ http://purl.uniprot.org/uniprot/G8ZWV5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.|||Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/4950:TDEL_0G03950 ^@ http://purl.uniprot.org/uniprot/G8ZXZ5 ^@ Similarity ^@ Belongs to the prokaryotic/mitochondrial release factor family. http://togogenome.org/gene/4950:TDEL_0C02410 ^@ http://purl.uniprot.org/uniprot/G8ZRI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0A01440 ^@ http://purl.uniprot.org/uniprot/G8ZLI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0E05160 ^@ http://purl.uniprot.org/uniprot/G8ZVW5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MPS2 family.|||Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Nucleus membrane|||spindle pole body http://togogenome.org/gene/4950:TDEL_0C06970 ^@ http://purl.uniprot.org/uniprot/G8ZQU9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0D01420 ^@ http://purl.uniprot.org/uniprot/G8ZSY2 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/4950:TDEL_0B00860 ^@ http://purl.uniprot.org/uniprot/G8ZNM1 ^@ Similarity ^@ Belongs to the THADA family. http://togogenome.org/gene/4950:TDEL_0E02520 ^@ http://purl.uniprot.org/uniprot/G8ZV51 ^@ Similarity ^@ Belongs to the peptidase C13 family. http://togogenome.org/gene/4950:TDEL_0D01280 ^@ http://purl.uniprot.org/uniprot/G8ZSW8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0C01170 ^@ http://purl.uniprot.org/uniprot/G8ZR64 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/4950:TDEL_0A00520 ^@ http://purl.uniprot.org/uniprot/G8ZL90 ^@ Similarity ^@ Belongs to the replication factor A protein 2 family. http://togogenome.org/gene/4950:TDEL_0C03480 ^@ http://purl.uniprot.org/uniprot/G8ZRU5 ^@ Similarity ^@ Belongs to the PPP4R2 family. http://togogenome.org/gene/4950:TDEL_0G02280 ^@ http://purl.uniprot.org/uniprot/G8ZTR9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H3 family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/4950:TDEL_0A06180 ^@ http://purl.uniprot.org/uniprot/G8ZMV6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the WD repeat PRL1/PRL2 family.|||Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E02010 ^@ http://purl.uniprot.org/uniprot/G8ZV00 ^@ Similarity ^@ Belongs to the peptidase M18 family. http://togogenome.org/gene/4950:TDEL_0A02890 ^@ http://purl.uniprot.org/uniprot/G8ZLX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OSBP family.|||Membrane http://togogenome.org/gene/4950:TDEL_0B02980 ^@ http://purl.uniprot.org/uniprot/G8ZP83 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0B04240 ^@ http://purl.uniprot.org/uniprot/G8ZPK9 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/4950:TDEL_0F01160 ^@ http://purl.uniprot.org/uniprot/G8ZWD3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-6 family.|||Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.|||Cytoplasm|||Monomer. Associates with the 60S ribosomal subunit.|||Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.|||nucleolus http://togogenome.org/gene/4950:TDEL_0G03380 ^@ http://purl.uniprot.org/uniprot/G8ZXT8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome.|||Nucleus|||Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends. http://togogenome.org/gene/4950:TDEL_0D04960 ^@ http://purl.uniprot.org/uniprot/G8ZTY6 ^@ Similarity ^@ Belongs to the SIN1 family. http://togogenome.org/gene/4950:TDEL_0F04980 ^@ http://purl.uniprot.org/uniprot/G8ZXG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGG1 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B07140 ^@ http://purl.uniprot.org/uniprot/G8ZQE9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion inner membrane|||Monomer. http://togogenome.org/gene/4950:TDEL_0B05380 ^@ http://purl.uniprot.org/uniprot/G8ZPX3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/4950:TDEL_0A03760 ^@ http://purl.uniprot.org/uniprot/G8ZM64 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/4950:TDEL_0B01210 ^@ http://purl.uniprot.org/uniprot/G8ZNQ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0C05820 ^@ http://purl.uniprot.org/uniprot/G8ZYB1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0F01040 ^@ http://purl.uniprot.org/uniprot/G8ZWC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0F04650 ^@ http://purl.uniprot.org/uniprot/G8ZXD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fungal Na(+)/H(+) exchanger family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D01000 ^@ http://purl.uniprot.org/uniprot/G8ZSU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NTE family.|||Endoplasmic reticulum membrane|||Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. http://togogenome.org/gene/4950:TDEL_0C03090 ^@ http://purl.uniprot.org/uniprot/G8ZRQ6 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/4950:TDEL_0D04330 ^@ http://purl.uniprot.org/uniprot/G8ZTS3 ^@ Similarity ^@ Belongs to the MNN1/MNT family. http://togogenome.org/gene/4950:TDEL_0F05350 ^@ http://purl.uniprot.org/uniprot/G8ZXK2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ4 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0H01060 ^@ http://purl.uniprot.org/uniprot/G8ZZC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TrkH potassium transport family.|||Membrane http://togogenome.org/gene/4950:TDEL_0B07560 ^@ http://purl.uniprot.org/uniprot/G8ZQJ1 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family. http://togogenome.org/gene/4950:TDEL_0A04030 ^@ http://purl.uniprot.org/uniprot/G8ZM91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/4950:TDEL_0H03410 ^@ http://purl.uniprot.org/uniprot/G9A006 ^@ Similarity ^@ Belongs to the gamma-BBH/TMLD family. http://togogenome.org/gene/4950:TDEL_0D05340 ^@ http://purl.uniprot.org/uniprot/G8ZU24 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D04230 ^@ http://purl.uniprot.org/uniprot/G8ZTR3 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0E02740 ^@ http://purl.uniprot.org/uniprot/G8ZV73 ^@ Similarity ^@ Belongs to the NOP10 family. http://togogenome.org/gene/4950:TDEL_0B07550 ^@ http://purl.uniprot.org/uniprot/G8ZQJ0 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/4950:TDEL_0E02230 ^@ http://purl.uniprot.org/uniprot/G8ZV22 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/4950:TDEL_0A05740 ^@ http://purl.uniprot.org/uniprot/G8ZMR2 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/4950:TDEL_0D03120 ^@ http://purl.uniprot.org/uniprot/G8ZTF2 ^@ Subcellular Location Annotation ^@ Peroxisome membrane http://togogenome.org/gene/4950:TDEL_0C06570 ^@ http://purl.uniprot.org/uniprot/G8ZQQ9 ^@ Similarity ^@ In the C-terminal section; belongs to the histidinol dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0B01620 ^@ http://purl.uniprot.org/uniprot/G8ZNU7 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/4950:TDEL_0D01650 ^@ http://purl.uniprot.org/uniprot/G8ZT05 ^@ Similarity ^@ Belongs to the peptidase M28 family. http://togogenome.org/gene/4950:TDEL_0F03300 ^@ http://purl.uniprot.org/uniprot/G8ZWZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pescadillo family.|||Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.|||Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/4950:TDEL_0A00670 ^@ http://purl.uniprot.org/uniprot/G8ZLA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0B06890 ^@ http://purl.uniprot.org/uniprot/G8ZQC4 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/4950:TDEL_0B05690 ^@ http://purl.uniprot.org/uniprot/G8ZQ04 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0F03350 ^@ http://purl.uniprot.org/uniprot/G8ZX02 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/4950:TDEL_0F00300 ^@ http://purl.uniprot.org/uniprot/G8ZW47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Bud neck http://togogenome.org/gene/4950:TDEL_0B02260 ^@ http://purl.uniprot.org/uniprot/G8ZP11 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NDC80/HEC1 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/4950:TDEL_0C01850 ^@ http://purl.uniprot.org/uniprot/G8ZRD2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit J family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0C02510 ^@ http://purl.uniprot.org/uniprot/G8ZRJ8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0B03150 ^@ http://purl.uniprot.org/uniprot/G8ZPA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0F01620 ^@ http://purl.uniprot.org/uniprot/G8ZWH9 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/4950:TDEL_0A06190 ^@ http://purl.uniprot.org/uniprot/G8ZMV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E02600 ^@ http://purl.uniprot.org/uniprot/G8ZV59 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0C02950 ^@ http://purl.uniprot.org/uniprot/G8ZRP2 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/4950:TDEL_0E05430 ^@ http://purl.uniprot.org/uniprot/G8ZVZ2 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/4950:TDEL_0E04840 ^@ http://purl.uniprot.org/uniprot/G8ZVT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase PH family.|||nucleolus http://togogenome.org/gene/4950:TDEL_0B06930 ^@ http://purl.uniprot.org/uniprot/G8ZQC8 ^@ Similarity ^@ Belongs to the CCS1 family. http://togogenome.org/gene/4950:TDEL_0C01390 ^@ http://purl.uniprot.org/uniprot/G8ZR86 ^@ Similarity ^@ Belongs to the YIP1 family. http://togogenome.org/gene/4950:TDEL_0C06120 ^@ http://purl.uniprot.org/uniprot/G8ZQL4 ^@ Similarity ^@ Belongs to the UFD1 family. http://togogenome.org/gene/4950:TDEL_0A02490 ^@ http://purl.uniprot.org/uniprot/G8ZLT7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0C04340 ^@ http://purl.uniprot.org/uniprot/G8ZS31 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/4950:TDEL_0D00600 ^@ http://purl.uniprot.org/uniprot/G8ZSQ0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/4950:TDEL_0D04580 ^@ http://purl.uniprot.org/uniprot/G8ZTU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Membrane http://togogenome.org/gene/4950:TDEL_0B06050 ^@ http://purl.uniprot.org/uniprot/G8ZQ40 ^@ Similarity ^@ Belongs to the UPF0357 family. http://togogenome.org/gene/4950:TDEL_0B03980 ^@ http://purl.uniprot.org/uniprot/G8ZPI3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/4950:TDEL_0D05990 ^@ http://purl.uniprot.org/uniprot/G8ZU89 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/4950:TDEL_0C06870 ^@ http://purl.uniprot.org/uniprot/G8ZQT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRB/QCR7 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0A04320 ^@ http://purl.uniprot.org/uniprot/G8ZMC0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0A03250 ^@ http://purl.uniprot.org/uniprot/G8ZM13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0A05400 ^@ http://purl.uniprot.org/uniprot/G8ZMM8 ^@ Similarity ^@ Belongs to the prephenate/arogenate dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0A04310 ^@ http://purl.uniprot.org/uniprot/G8ZMB9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS13 family. http://togogenome.org/gene/4950:TDEL_0B01820 ^@ http://purl.uniprot.org/uniprot/G8ZNW7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.|||Mitochondrion matrix http://togogenome.org/gene/4950:TDEL_0C04980 ^@ http://purl.uniprot.org/uniprot/G8ZS95 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.|||Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. http://togogenome.org/gene/4950:TDEL_0F04360 ^@ http://purl.uniprot.org/uniprot/G8ZXA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BBP/SF1 family.|||Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.|||Nucleus http://togogenome.org/gene/4950:TDEL_0H01160 ^@ http://purl.uniprot.org/uniprot/G8ZZD1 ^@ Cofactor|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/4950:TDEL_0B00770 ^@ http://purl.uniprot.org/uniprot/G8ZNL2 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/4950:TDEL_0B03990 ^@ http://purl.uniprot.org/uniprot/G8ZPI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0C02320 ^@ http://purl.uniprot.org/uniprot/G8ZRH9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/4950:TDEL_0F00720 ^@ http://purl.uniprot.org/uniprot/G8ZW89 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/4950:TDEL_0C00100 ^@ http://purl.uniprot.org/uniprot/G8ZQV7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0A01790 ^@ http://purl.uniprot.org/uniprot/G8ZLL7 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/4950:TDEL_0A03510 ^@ http://purl.uniprot.org/uniprot/G8ZM39 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/4950:TDEL_0E03360 ^@ http://purl.uniprot.org/uniprot/G8ZVD5 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/4950:TDEL_0E02090 ^@ http://purl.uniprot.org/uniprot/G8ZV08 ^@ Function|||Similarity ^@ Belongs to the BLOC1S4 family.|||Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting. http://togogenome.org/gene/4950:TDEL_0C01600 ^@ http://purl.uniprot.org/uniprot/G8ZRA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.|||spindle http://togogenome.org/gene/4950:TDEL_0C02780 ^@ http://purl.uniprot.org/uniprot/G8ZRM5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/4950:TDEL_0F02380 ^@ http://purl.uniprot.org/uniprot/G8ZWQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLA1 family.|||Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0E02560 ^@ http://purl.uniprot.org/uniprot/G8ZV55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-3 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/4950:TDEL_0A07220 ^@ http://purl.uniprot.org/uniprot/G8ZN60 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0A01510 ^@ http://purl.uniprot.org/uniprot/G8ZLI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS41 family.|||Required for vacuolar assembly and vacuolar traffic.|||Vacuole http://togogenome.org/gene/4950:TDEL_0A02340 ^@ http://purl.uniprot.org/uniprot/G8ZLS2 ^@ Similarity ^@ Belongs to the AP endonuclease 2 family. http://togogenome.org/gene/4950:TDEL_0B00140 ^@ http://purl.uniprot.org/uniprot/G8ZNE9 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/4950:TDEL_0H04010 ^@ http://purl.uniprot.org/uniprot/G9A066 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. http://togogenome.org/gene/4950:TDEL_0E02390 ^@ http://purl.uniprot.org/uniprot/G8ZV38 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GAR1 family.|||Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).|||Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.|||nucleolus http://togogenome.org/gene/4950:TDEL_0A04150 ^@ http://purl.uniprot.org/uniprot/G8ZMA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0E03330 ^@ http://purl.uniprot.org/uniprot/G8ZVD2 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/4950:TDEL_0A00910 ^@ http://purl.uniprot.org/uniprot/G8ZLC9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NnrE/AIBP family.|||Binds 1 potassium ion per subunit.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0C02390 ^@ http://purl.uniprot.org/uniprot/G8ZRI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/4950:TDEL_0B06650 ^@ http://purl.uniprot.org/uniprot/G8ZQA0 ^@ Domain|||Function|||Similarity ^@ Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.|||Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.|||Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine. http://togogenome.org/gene/4950:TDEL_0B02470 ^@ http://purl.uniprot.org/uniprot/G8ZP32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DASH complex DAD2 family.|||Nucleus|||kinetochore|||spindle http://togogenome.org/gene/4950:TDEL_0F03340 ^@ http://purl.uniprot.org/uniprot/G8ZX01 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0E02980 ^@ http://purl.uniprot.org/uniprot/G8ZV97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0B02580 ^@ http://purl.uniprot.org/uniprot/G8ZP43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ING family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C05800 ^@ http://purl.uniprot.org/uniprot/G8ZQV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0E01090 ^@ http://purl.uniprot.org/uniprot/G8ZUQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. SKI2 subfamily.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0B01260 ^@ http://purl.uniprot.org/uniprot/G8ZNR1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.|||Endoplasmic reticulum membrane http://togogenome.org/gene/4950:TDEL_0F01370 ^@ http://purl.uniprot.org/uniprot/G8ZWF4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/4950:TDEL_0A06710 ^@ http://purl.uniprot.org/uniprot/G8ZN09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Membrane http://togogenome.org/gene/4950:TDEL_0H00710 ^@ http://purl.uniprot.org/uniprot/G8ZZ86 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0H04320 ^@ http://purl.uniprot.org/uniprot/G9A097 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial Rho GTPase family.|||Membrane|||Mitochondrial GTPase involved in mitochondrial trafficking.|||Mitochondrion outer membrane http://togogenome.org/gene/4950:TDEL_0F04350 ^@ http://purl.uniprot.org/uniprot/G8ZXA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/4950:TDEL_0H02810 ^@ http://purl.uniprot.org/uniprot/G8ZZU6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.|||Binds 1 FAD per subunit.|||Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0D02170 ^@ http://purl.uniprot.org/uniprot/G8ZT57 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. http://togogenome.org/gene/4950:TDEL_0G04600 ^@ http://purl.uniprot.org/uniprot/G8ZY60 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins. http://togogenome.org/gene/4950:TDEL_0A06730 ^@ http://purl.uniprot.org/uniprot/G8ZN11 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0B01890 ^@ http://purl.uniprot.org/uniprot/G8ZNX4 ^@ Similarity ^@ Belongs to the MGMT family. http://togogenome.org/gene/4950:TDEL_0C06330 ^@ http://purl.uniprot.org/uniprot/G8ZQN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family.|||Cytoplasm|||Membrane http://togogenome.org/gene/4950:TDEL_0C03080 ^@ http://purl.uniprot.org/uniprot/G8ZRQ5 ^@ Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family. http://togogenome.org/gene/4950:TDEL_0A03010 ^@ http://purl.uniprot.org/uniprot/G8ZLY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0B01910 ^@ http://purl.uniprot.org/uniprot/G8ZNX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A03590 ^@ http://purl.uniprot.org/uniprot/G8ZM47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E02660 ^@ http://purl.uniprot.org/uniprot/G8ZV65 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/4950:TDEL_0H02510 ^@ http://purl.uniprot.org/uniprot/G8ZZR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tim44 family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0C05500 ^@ http://purl.uniprot.org/uniprot/G8ZSE7 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/4950:TDEL_0C02980 ^@ http://purl.uniprot.org/uniprot/G8ZRP5 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/4950:TDEL_0E04960 ^@ http://purl.uniprot.org/uniprot/G8ZVU5 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/4950:TDEL_0G04490 ^@ http://purl.uniprot.org/uniprot/G8ZY49 ^@ Similarity ^@ Belongs to the UPF0507 family. http://togogenome.org/gene/4950:TDEL_0D04840 ^@ http://purl.uniprot.org/uniprot/G8ZTX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D01900 ^@ http://purl.uniprot.org/uniprot/G8ZT30 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/4950:TDEL_0D01710 ^@ http://purl.uniprot.org/uniprot/G8ZT11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL41 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0A00570 ^@ http://purl.uniprot.org/uniprot/G8ZL95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A02510 ^@ http://purl.uniprot.org/uniprot/G8ZLT9 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/4950:TDEL_0A05010 ^@ http://purl.uniprot.org/uniprot/G8ZMI9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the casein kinase 2 subunit beta family.|||Regulatory subunit of casein kinase II/CK2 (By similarity). As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.|||Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/4950:TDEL_0B03670 ^@ http://purl.uniprot.org/uniprot/G8ZPF2 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/4950:TDEL_0C06440 ^@ http://purl.uniprot.org/uniprot/G8ZQP6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/4950:TDEL_0E04160 ^@ http://purl.uniprot.org/uniprot/G8ZVL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC3 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E02300 ^@ http://purl.uniprot.org/uniprot/G8ZV29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0H01850 ^@ http://purl.uniprot.org/uniprot/G8ZZK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDA2 family.|||Cell projection|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0E02440 ^@ http://purl.uniprot.org/uniprot/G8ZV43 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0G01240 ^@ http://purl.uniprot.org/uniprot/G8ZYL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.|||Belongs to the ALG10 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0F04900 ^@ http://purl.uniprot.org/uniprot/G8ZXF7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0B03260 ^@ http://purl.uniprot.org/uniprot/G8ZPB1 ^@ Similarity ^@ Belongs to the glycosyltransferase 15 family. http://togogenome.org/gene/4950:TDEL_0E01160 ^@ http://purl.uniprot.org/uniprot/G8ZUR5 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/4950:TDEL_0A02450 ^@ http://purl.uniprot.org/uniprot/G8ZLT3 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/4950:TDEL_0C00390 ^@ http://purl.uniprot.org/uniprot/G8ZQY6 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0C06310 ^@ http://purl.uniprot.org/uniprot/G8ZQN3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC25 family.|||Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.|||Nucleus|||kinetochore http://togogenome.org/gene/4950:TDEL_0A02060 ^@ http://purl.uniprot.org/uniprot/G8ZLP4 ^@ Function|||Similarity ^@ Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.|||Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/4950:TDEL_0D06240 ^@ http://purl.uniprot.org/uniprot/G8ZUB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0E04790 ^@ http://purl.uniprot.org/uniprot/G8ZVS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0A06790 ^@ http://purl.uniprot.org/uniprot/G8ZN17 ^@ Similarity ^@ Belongs to the Tango6 family. http://togogenome.org/gene/4950:TDEL_0D03150 ^@ http://purl.uniprot.org/uniprot/G8ZTF5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SWC4 family.|||Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E04400 ^@ http://purl.uniprot.org/uniprot/G8ZVN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCR10/QCR9 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0D00370 ^@ http://purl.uniprot.org/uniprot/G8ZSM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MGM101 family.|||mitochondrion nucleoid http://togogenome.org/gene/4950:TDEL_0C01520 ^@ http://purl.uniprot.org/uniprot/G8ZR99 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS8 family. http://togogenome.org/gene/4950:TDEL_0E00360 ^@ http://purl.uniprot.org/uniprot/G8ZUI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG2 family.|||Endoplasmic reticulum membrane|||Membrane|||Preautophagosomal structure membrane http://togogenome.org/gene/4950:TDEL_0D01180 ^@ http://purl.uniprot.org/uniprot/G8ZSV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize preautophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.|||Belongs to the ATG17 family.|||Cytoplasm|||Membrane|||Preautophagosomal structure membrane http://togogenome.org/gene/4950:TDEL_0G04130 ^@ http://purl.uniprot.org/uniprot/G8ZY13 ^@ Similarity ^@ Belongs to the GET4 family. http://togogenome.org/gene/4950:TDEL_0B07640 ^@ http://purl.uniprot.org/uniprot/G8ZQJ9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/4950:TDEL_0H01820 ^@ http://purl.uniprot.org/uniprot/G8ZZJ7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/4950:TDEL_0D04280 ^@ http://purl.uniprot.org/uniprot/G8ZYX1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/4950:TDEL_0E03690 ^@ http://purl.uniprot.org/uniprot/G8ZVG8 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/4950:TDEL_0G04890 ^@ http://purl.uniprot.org/uniprot/G8ZY89 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0G01060 ^@ http://purl.uniprot.org/uniprot/G8ZYJ8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/4950:TDEL_0F01810 ^@ http://purl.uniprot.org/uniprot/G8ZWJ8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0A07890 ^@ http://purl.uniprot.org/uniprot/G8ZNC7 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/4950:TDEL_0B04330 ^@ http://purl.uniprot.org/uniprot/G8ZPL8 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/4950:TDEL_0B01730 ^@ http://purl.uniprot.org/uniprot/G8ZNV8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/4950:TDEL_0A05920 ^@ http://purl.uniprot.org/uniprot/G8ZMT0 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RPB8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/4950:TDEL_0G03700 ^@ http://purl.uniprot.org/uniprot/G8ZXX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HRI1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0G04940 ^@ http://purl.uniprot.org/uniprot/G8ZY94 ^@ Similarity ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily. http://togogenome.org/gene/4950:TDEL_0A02310 ^@ http://purl.uniprot.org/uniprot/G8ZLR9 ^@ Similarity ^@ Belongs to the p23/wos2 family. http://togogenome.org/gene/4950:TDEL_0C05110 ^@ http://purl.uniprot.org/uniprot/G8ZSA8 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate. http://togogenome.org/gene/4950:TDEL_0A02970 ^@ http://purl.uniprot.org/uniprot/G8ZLY5 ^@ Similarity ^@ Belongs to the adaptor complexes medium subunit family. http://togogenome.org/gene/4950:TDEL_0E02670 ^@ http://purl.uniprot.org/uniprot/G8ZV66 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase e subunit family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0E02690 ^@ http://purl.uniprot.org/uniprot/G8ZV68 ^@ Function|||Similarity ^@ Belongs to the AB hydrolase superfamily.|||Demethylates proteins that have been reversibly carboxymethylated. http://togogenome.org/gene/4950:TDEL_0A07360 ^@ http://purl.uniprot.org/uniprot/G8ZN74 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family. http://togogenome.org/gene/4950:TDEL_0D06380 ^@ http://purl.uniprot.org/uniprot/G8ZUC8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DXO/Dom3Z family.|||Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E03520 ^@ http://purl.uniprot.org/uniprot/G8ZVF1 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/4950:TDEL_0B05590 ^@ http://purl.uniprot.org/uniprot/G8ZPZ4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/4950:TDEL_0E05290 ^@ http://purl.uniprot.org/uniprot/G8ZVX8 ^@ Similarity ^@ Belongs to the TYW1 family. http://togogenome.org/gene/4950:TDEL_0C04900 ^@ http://purl.uniprot.org/uniprot/G8ZS87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0H03470 ^@ http://purl.uniprot.org/uniprot/G9A012 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MDM10 family.|||Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.|||Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.|||Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.|||Mitochondrion outer membrane http://togogenome.org/gene/4950:TDEL_0A07450 ^@ http://purl.uniprot.org/uniprot/G8ZN83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D02510 ^@ http://purl.uniprot.org/uniprot/G8ZT91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ferredoxin--NADP reductase type 1 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0C06160 ^@ http://purl.uniprot.org/uniprot/G8ZQL8 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/4950:TDEL_0C00640 ^@ http://purl.uniprot.org/uniprot/G8ZR11 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/4950:TDEL_0F00450 ^@ http://purl.uniprot.org/uniprot/G8ZW62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YAE1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0E04670 ^@ http://purl.uniprot.org/uniprot/G8ZVR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0F03530 ^@ http://purl.uniprot.org/uniprot/G8ZX20 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0E05660 ^@ http://purl.uniprot.org/uniprot/G8ZW15 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/4950:TDEL_0F02550 ^@ http://purl.uniprot.org/uniprot/G8ZWS2 ^@ Similarity ^@ In the C-terminal section; belongs to the TrpB family.|||In the N-terminal section; belongs to the TrpA family. http://togogenome.org/gene/4950:TDEL_0F02100 ^@ http://purl.uniprot.org/uniprot/G8ZWM7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/4950:TDEL_0G00460 ^@ http://purl.uniprot.org/uniprot/G8ZYD8 ^@ Similarity ^@ Belongs to the REXO1/REXO3 family. http://togogenome.org/gene/4950:TDEL_0H00850 ^@ http://purl.uniprot.org/uniprot/G8ZZA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFH5 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane|||Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. http://togogenome.org/gene/4950:TDEL_0G01780 ^@ http://purl.uniprot.org/uniprot/G8ZYS0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.|||Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0D03110 ^@ http://purl.uniprot.org/uniprot/G8ZTF1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL38 family. http://togogenome.org/gene/4950:TDEL_0D00320 ^@ http://purl.uniprot.org/uniprot/G8ZSM2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0B01840 ^@ http://purl.uniprot.org/uniprot/G8ZNW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COX20 family.|||Involved in the assembly of the cytochrome c oxidase complex.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0H00150 ^@ http://purl.uniprot.org/uniprot/G8ZZ30 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/4950:TDEL_0H01730 ^@ http://purl.uniprot.org/uniprot/G8ZZI8 ^@ Similarity ^@ Belongs to the AIM9 family. http://togogenome.org/gene/4950:TDEL_0D06290 ^@ http://purl.uniprot.org/uniprot/G8ZUB9 ^@ Similarity ^@ Belongs to the XPO2/CSE1 family. http://togogenome.org/gene/4950:TDEL_0E03100 ^@ http://purl.uniprot.org/uniprot/G8ZVA9 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/4950:TDEL_0A03840 ^@ http://purl.uniprot.org/uniprot/G8ZM72 ^@ Similarity ^@ Belongs to the AFG1 ATPase family. http://togogenome.org/gene/4950:TDEL_0D00220 ^@ http://purl.uniprot.org/uniprot/G8ZSL2 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/4950:TDEL_0D00930 ^@ http://purl.uniprot.org/uniprot/G8ZST3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0E00760 ^@ http://purl.uniprot.org/uniprot/G8ZUM5 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/4950:TDEL_0E02920 ^@ http://purl.uniprot.org/uniprot/G8ZV91 ^@ Similarity ^@ Belongs to the ketopantoate reductase family. http://togogenome.org/gene/4950:TDEL_0A04790 ^@ http://purl.uniprot.org/uniprot/G8ZMG7 ^@ Similarity ^@ Belongs to the sirtuin family. Class I subfamily. http://togogenome.org/gene/4950:TDEL_0A07700 ^@ http://purl.uniprot.org/uniprot/G8ZNA8 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/4950:TDEL_0F00220 ^@ http://purl.uniprot.org/uniprot/G8ZW39 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0A00130 ^@ http://purl.uniprot.org/uniprot/G8ZL51 ^@ Similarity ^@ Belongs to the NtaA/SnaA/DszA monooxygenase family. http://togogenome.org/gene/4950:TDEL_0B05480 ^@ http://purl.uniprot.org/uniprot/G8ZPY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0F04840 ^@ http://purl.uniprot.org/uniprot/G8ZXF1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF10 family.|||Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation), facilitation of DNA opening and initiation of transcription. SAGA is required for recruitment of the basal transcription machinery. SLIK is proposed to have partly overlapping functions with SAGA.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C04580 ^@ http://purl.uniprot.org/uniprot/G8ZS55 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0F00750 ^@ http://purl.uniprot.org/uniprot/G8ZW92 ^@ Similarity ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family. http://togogenome.org/gene/4950:TDEL_0D04520 ^@ http://purl.uniprot.org/uniprot/G8ZTU2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M49 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/4950:TDEL_0E03570 ^@ http://purl.uniprot.org/uniprot/G8ZVF6 ^@ Similarity ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily. http://togogenome.org/gene/4950:TDEL_0D03470 ^@ http://purl.uniprot.org/uniprot/G8ZTI7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS10 family. http://togogenome.org/gene/4950:TDEL_0C02860 ^@ http://purl.uniprot.org/uniprot/G8ZRN3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/4950:TDEL_0A04380 ^@ http://purl.uniprot.org/uniprot/G8ZMC6 ^@ Similarity ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. http://togogenome.org/gene/4950:TDEL_0F04690 ^@ http://purl.uniprot.org/uniprot/G8ZXD6 ^@ Function|||Similarity ^@ Belongs to the CWC15 family.|||Involved in pre-mRNA splicing. http://togogenome.org/gene/4950:TDEL_0A03410 ^@ http://purl.uniprot.org/uniprot/G8ZM29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||Nucleus|||Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. http://togogenome.org/gene/4950:TDEL_0B02870 ^@ http://purl.uniprot.org/uniprot/G8ZP72 ^@ Similarity ^@ Belongs to the AAA ATPase family. PCH2 subfamily. http://togogenome.org/gene/4950:TDEL_0D03130 ^@ http://purl.uniprot.org/uniprot/G8ZTF3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the CWC24 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G03060 ^@ http://purl.uniprot.org/uniprot/G8ZXQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OSW5 family.|||Involved in spore wall assembly.|||Membrane http://togogenome.org/gene/4950:TDEL_0C02700 ^@ http://purl.uniprot.org/uniprot/G8ZRL7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D06550 ^@ http://purl.uniprot.org/uniprot/G8ZUE5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/4950:TDEL_0G03910 ^@ http://purl.uniprot.org/uniprot/G8ZXZ1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. http://togogenome.org/gene/4950:TDEL_0G00590 ^@ http://purl.uniprot.org/uniprot/G8ZYF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B02970 ^@ http://purl.uniprot.org/uniprot/G8ZP82 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ATPase B chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0C04830 ^@ http://purl.uniprot.org/uniprot/G8ZS80 ^@ Similarity ^@ Belongs to the EME1/MMS4 family. http://togogenome.org/gene/4950:TDEL_0C05340 ^@ http://purl.uniprot.org/uniprot/G8ZSD1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0G04380 ^@ http://purl.uniprot.org/uniprot/G8ZY38 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/4950:TDEL_0D02180 ^@ http://purl.uniprot.org/uniprot/G8ZT58 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0E01970 ^@ http://purl.uniprot.org/uniprot/G8ZUZ6 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/4950:TDEL_0F02950 ^@ http://purl.uniprot.org/uniprot/G8ZWW2 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/4950:TDEL_0H03260 ^@ http://purl.uniprot.org/uniprot/G8ZZZ1 ^@ Similarity ^@ Belongs to the MNN1/MNT family. http://togogenome.org/gene/4950:TDEL_0B04920 ^@ http://purl.uniprot.org/uniprot/G8ZPS7 ^@ Similarity ^@ Belongs to the CAP family. http://togogenome.org/gene/4950:TDEL_0G02290 ^@ http://purl.uniprot.org/uniprot/G8ZYX1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/4950:TDEL_0E00330 ^@ http://purl.uniprot.org/uniprot/G8ZYB1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0B05890 ^@ http://purl.uniprot.org/uniprot/G8ZQ24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RER1 family.|||Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.|||Membrane http://togogenome.org/gene/4950:TDEL_0B01410 ^@ http://purl.uniprot.org/uniprot/G8ZNS6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SGF11 family.|||Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with SGF73, SUS1 and UBP8.|||Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). Involved in transcriptional regulation of a subset of SAGA-regulated genes. Within the SAGA complex, participates in a subcomplex, that specifically deubiquitinates histones H2B.|||Nucleus|||The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of UBP8 forms the 'catalytic lobe' of the SAGA deubiquitination module.|||The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module. http://togogenome.org/gene/4950:TDEL_0F02230 ^@ http://purl.uniprot.org/uniprot/G8ZWP0 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/4950:TDEL_0C01820 ^@ http://purl.uniprot.org/uniprot/G8ZRC9 ^@ Similarity ^@ Belongs to the peroxin-13 family. http://togogenome.org/gene/4950:TDEL_0C04710 ^@ http://purl.uniprot.org/uniprot/G8ZS68 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.|||Cytoplasm|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion|||NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death. http://togogenome.org/gene/4950:TDEL_0A00360 ^@ http://purl.uniprot.org/uniprot/G8ZL74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion matrix http://togogenome.org/gene/4950:TDEL_0E04830 ^@ http://purl.uniprot.org/uniprot/G8ZVT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGM family.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.|||Membrane http://togogenome.org/gene/4950:TDEL_0C04440 ^@ http://purl.uniprot.org/uniprot/G8ZS41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0E01500 ^@ http://purl.uniprot.org/uniprot/G8ZUU9 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/4950:TDEL_0B05390 ^@ http://purl.uniprot.org/uniprot/G8ZPX4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0E02840 ^@ http://purl.uniprot.org/uniprot/G8ZV83 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/4950:TDEL_0F00330 ^@ http://purl.uniprot.org/uniprot/G8ZW50 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/4950:TDEL_0D03490 ^@ http://purl.uniprot.org/uniprot/G8ZTI9 ^@ Similarity ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily. http://togogenome.org/gene/4950:TDEL_0H02330 ^@ http://purl.uniprot.org/uniprot/G8ZZP8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.|||Belongs to the CNOT2/3/5 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0E02140 ^@ http://purl.uniprot.org/uniprot/G8ZV13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YPT35 family.|||Endosome membrane|||Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0A02230 ^@ http://purl.uniprot.org/uniprot/G8ZLR1 ^@ Similarity ^@ Belongs to the RRN3 family. http://togogenome.org/gene/4950:TDEL_0E03790 ^@ http://purl.uniprot.org/uniprot/G8ZVH8 ^@ Similarity ^@ Belongs to the NOP9 family. http://togogenome.org/gene/4950:TDEL_0D00980 ^@ http://purl.uniprot.org/uniprot/G8ZST8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/4950:TDEL_0D05680 ^@ http://purl.uniprot.org/uniprot/G8ZU58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0G02510 ^@ http://purl.uniprot.org/uniprot/G8ZYZ3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/4950:TDEL_0A07960 ^@ http://purl.uniprot.org/uniprot/G8ZND4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF2/ABP1 family.|||nucleolus http://togogenome.org/gene/4950:TDEL_0F03860 ^@ http://purl.uniprot.org/uniprot/G8ZX53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C00810 ^@ http://purl.uniprot.org/uniprot/G8ZR28 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0A00440 ^@ http://purl.uniprot.org/uniprot/G8ZL82 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle. http://togogenome.org/gene/4950:TDEL_0A03460 ^@ http://purl.uniprot.org/uniprot/G8ZM34 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/4950:TDEL_0E03820 ^@ http://purl.uniprot.org/uniprot/G8ZVI1 ^@ Similarity ^@ Belongs to the MAD2 family. http://togogenome.org/gene/4950:TDEL_0F01380 ^@ http://purl.uniprot.org/uniprot/G8ZWF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0B07650 ^@ http://purl.uniprot.org/uniprot/G8ZQK0 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. PAN3 family.|||Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.|||Cytoplasm|||Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.|||The N-terminal zinc finger binds to poly(A) RNA.|||The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2. http://togogenome.org/gene/4950:TDEL_0G03490 ^@ http://purl.uniprot.org/uniprot/G8ZXU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosyl-DNA phosphodiesterase family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0H01930 ^@ http://purl.uniprot.org/uniprot/G8ZZK8 ^@ Similarity|||Subcellular Location Annotation ^@ In the C-terminal section; belongs to the NAGSA dehydrogenase family.|||In the N-terminal section; belongs to the acetylglutamate kinase family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0C02370 ^@ http://purl.uniprot.org/uniprot/G8ZRI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D06070 ^@ http://purl.uniprot.org/uniprot/G8ZU97 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0B05190 ^@ http://purl.uniprot.org/uniprot/G8ZPV4 ^@ Similarity ^@ Belongs to the malate synthase family. http://togogenome.org/gene/4950:TDEL_0H04410 ^@ http://purl.uniprot.org/uniprot/G9A0A6 ^@ Function|||Similarity ^@ Belongs to the Rab GDI family.|||Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. http://togogenome.org/gene/4950:TDEL_0A00770 ^@ http://purl.uniprot.org/uniprot/G8ZLB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRG9 family.|||Mitochondrion|||Required for respiratory activity and maintenance and expression of the mitochondrial genome. http://togogenome.org/gene/4950:TDEL_0G00480 ^@ http://purl.uniprot.org/uniprot/G8ZYE0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0G01210 ^@ http://purl.uniprot.org/uniprot/G8ZYL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0A03280 ^@ http://purl.uniprot.org/uniprot/G8ZM16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0B06990 ^@ http://purl.uniprot.org/uniprot/G8ZQD4 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/4950:TDEL_0E05360 ^@ http://purl.uniprot.org/uniprot/G8ZVY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS29 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0C01320 ^@ http://purl.uniprot.org/uniprot/G8ZR79 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.|||Can also use Mn(2+) ion. http://togogenome.org/gene/4950:TDEL_0B05130 ^@ http://purl.uniprot.org/uniprot/G8ZPU8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/4950:TDEL_0C00800 ^@ http://purl.uniprot.org/uniprot/G8ZR27 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/4950:TDEL_0B00110 ^@ http://purl.uniprot.org/uniprot/G8ZNE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GMC oxidoreductase family.|||Peroxisome matrix http://togogenome.org/gene/4950:TDEL_0B04140 ^@ http://purl.uniprot.org/uniprot/G8ZPJ9 ^@ Similarity ^@ Belongs to the SCC4/mau-2 family. http://togogenome.org/gene/4950:TDEL_0D04150 ^@ http://purl.uniprot.org/uniprot/G8ZTQ5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/4950:TDEL_0C05580 ^@ http://purl.uniprot.org/uniprot/G8ZSF5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CPSF4/YTH1 family.|||Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.|||Nucleus http://togogenome.org/gene/4950:TDEL_0F00540 ^@ http://purl.uniprot.org/uniprot/G8ZW71 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/4950:TDEL_0A07770 ^@ http://purl.uniprot.org/uniprot/G8ZNB5 ^@ Similarity ^@ Belongs to the diphosphomevalonate decarboxylase family. http://togogenome.org/gene/4950:TDEL_0A03260 ^@ http://purl.uniprot.org/uniprot/G8ZM14 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family. http://togogenome.org/gene/4950:TDEL_0C02190 ^@ http://purl.uniprot.org/uniprot/G8ZRG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP14 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.|||nucleolus http://togogenome.org/gene/4950:TDEL_0B03900 ^@ http://purl.uniprot.org/uniprot/G8ZPH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the USE1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0F01770 ^@ http://purl.uniprot.org/uniprot/G8ZWJ4 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/4950:TDEL_0A06700 ^@ http://purl.uniprot.org/uniprot/G8ZN08 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family. http://togogenome.org/gene/4950:TDEL_0B03510 ^@ http://purl.uniprot.org/uniprot/G8ZPD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D01120 ^@ http://purl.uniprot.org/uniprot/G8ZSV2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/4950:TDEL_0C06590 ^@ http://purl.uniprot.org/uniprot/G8ZQR1 ^@ Similarity ^@ Belongs to the RRP7 family. http://togogenome.org/gene/4950:TDEL_0E05710 ^@ http://purl.uniprot.org/uniprot/G8ZW20 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/4950:TDEL_0F02430 ^@ http://purl.uniprot.org/uniprot/G8ZWR0 ^@ Similarity ^@ Belongs to the R-transferase family. http://togogenome.org/gene/4950:TDEL_0B02520 ^@ http://purl.uniprot.org/uniprot/G8ZP37 ^@ Similarity ^@ Belongs to the RNase Z family. http://togogenome.org/gene/4950:TDEL_0C03020 ^@ http://purl.uniprot.org/uniprot/G8ZRP9 ^@ Similarity ^@ Belongs to the MNN1/MNT family. http://togogenome.org/gene/4950:TDEL_0D05220 ^@ http://purl.uniprot.org/uniprot/G8ZU12 ^@ Similarity ^@ Belongs to the VPS52 family. http://togogenome.org/gene/4950:TDEL_0C05660 ^@ http://purl.uniprot.org/uniprot/G8ZSG3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0G02620 ^@ http://purl.uniprot.org/uniprot/G8ZZ04 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/4950:TDEL_0C06820 ^@ http://purl.uniprot.org/uniprot/G8ZQT4 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/4950:TDEL_0C04260 ^@ http://purl.uniprot.org/uniprot/G8ZS23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0A00860 ^@ http://purl.uniprot.org/uniprot/G8ZLC4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/4950:TDEL_0B02150 ^@ http://purl.uniprot.org/uniprot/G8ZP00 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/4950:TDEL_0C04170 ^@ http://purl.uniprot.org/uniprot/G8ZS14 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type II topoisomerase family.|||Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.|||Homodimer. http://togogenome.org/gene/4950:TDEL_0C04720 ^@ http://purl.uniprot.org/uniprot/G8ZS69 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG11 family.|||Homodimer.|||Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.|||Membrane|||Preautophagosomal structure membrane|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0C01690 ^@ http://purl.uniprot.org/uniprot/G8ZRB6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the vitamin-B12 independent methionine synthase family.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation. http://togogenome.org/gene/4950:TDEL_0E05270 ^@ http://purl.uniprot.org/uniprot/G8ZVX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Endoplasmic reticulum membrane|||Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. http://togogenome.org/gene/4950:TDEL_0D03310 ^@ http://purl.uniprot.org/uniprot/G8ZTH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0G03600 ^@ http://purl.uniprot.org/uniprot/G8ZXW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/4950:TDEL_0C06940 ^@ http://purl.uniprot.org/uniprot/G8ZQU6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic10 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0E02160 ^@ http://purl.uniprot.org/uniprot/G8ZV15 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0H03990 ^@ http://purl.uniprot.org/uniprot/G9A064 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPA43 RNA polymerase subunit family.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/4950:TDEL_0F01870 ^@ http://purl.uniprot.org/uniprot/G8ZWK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0B04310 ^@ http://purl.uniprot.org/uniprot/G8ZPL6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/4950:TDEL_0C00570 ^@ http://purl.uniprot.org/uniprot/G8ZR04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMCO4 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D05020 ^@ http://purl.uniprot.org/uniprot/G8ZTZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0D00510 ^@ http://purl.uniprot.org/uniprot/G8ZSP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RIX1/PELP1 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E05760 ^@ http://purl.uniprot.org/uniprot/G8ZW25 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 32 family. http://togogenome.org/gene/4950:TDEL_0E00260 ^@ http://purl.uniprot.org/uniprot/G8ZUH5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription.|||Cytoplasm|||Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome.|||Nucleus|||Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends.|||The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.|||The capsid protein forms a homotrimer, from which the VLPs are assembled. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues. http://togogenome.org/gene/4950:TDEL_0E02760 ^@ http://purl.uniprot.org/uniprot/G8ZV75 ^@ Similarity ^@ Belongs to the terpene cyclase/mutase family. http://togogenome.org/gene/4950:TDEL_0A05870 ^@ http://purl.uniprot.org/uniprot/G8ZMS5 ^@ Function|||Subcellular Location Annotation ^@ Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0A04010 ^@ http://purl.uniprot.org/uniprot/G8ZM89 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT5 family.|||Nucleus|||The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. http://togogenome.org/gene/4950:TDEL_0A01550 ^@ http://purl.uniprot.org/uniprot/G8ZLJ3 ^@ Similarity ^@ Belongs to the MYG1 family. http://togogenome.org/gene/4950:TDEL_0F03680 ^@ http://purl.uniprot.org/uniprot/G8ZX35 ^@ Similarity ^@ Belongs to the CDC73 family. http://togogenome.org/gene/4950:TDEL_0B06640 ^@ http://purl.uniprot.org/uniprot/G8ZQ99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pex2/pex10/pex12 family.|||Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.|||Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/4950:TDEL_0F03600 ^@ http://purl.uniprot.org/uniprot/G8ZX27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0B06730 ^@ http://purl.uniprot.org/uniprot/G8ZQA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. http://togogenome.org/gene/4950:TDEL_0H04070 ^@ http://purl.uniprot.org/uniprot/G9A072 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D01480 ^@ http://purl.uniprot.org/uniprot/G8ZSY8 ^@ Similarity ^@ Belongs to the TRL1 family. http://togogenome.org/gene/4950:TDEL_0G00280 ^@ http://purl.uniprot.org/uniprot/G8ZYC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0C06580 ^@ http://purl.uniprot.org/uniprot/G8ZQR0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I LYR family. SDHAF3 subfamily.|||Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. http://togogenome.org/gene/4950:TDEL_0D02590 ^@ http://purl.uniprot.org/uniprot/G8ZT99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0B00680 ^@ http://purl.uniprot.org/uniprot/G8ZNK3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sterol desaturase family. SCS7 subfamily.|||Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.|||Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0A02030 ^@ http://purl.uniprot.org/uniprot/G8ZLP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC24 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/4950:TDEL_0D02010 ^@ http://purl.uniprot.org/uniprot/G8ZT41 ^@ Similarity ^@ Belongs to the VPS26 family. http://togogenome.org/gene/4950:TDEL_0E03650 ^@ http://purl.uniprot.org/uniprot/G8ZVG4 ^@ Similarity ^@ Belongs to the NUP186/NUP192/NUP205 family. http://togogenome.org/gene/4950:TDEL_0H02050 ^@ http://purl.uniprot.org/uniprot/G8ZZM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PET117 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0B02320 ^@ http://purl.uniprot.org/uniprot/G8ZP17 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/4950:TDEL_0C03950 ^@ http://purl.uniprot.org/uniprot/G8ZRZ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.|||Endoplasmic reticulum membrane|||Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. http://togogenome.org/gene/4950:TDEL_0D00570 ^@ http://purl.uniprot.org/uniprot/G8ZSP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAC-alpha family.|||Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0B00100 ^@ http://purl.uniprot.org/uniprot/G8ZNE5 ^@ Function|||Similarity ^@ Belongs to the catalase family.|||Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. http://togogenome.org/gene/4950:TDEL_0G03990 ^@ http://purl.uniprot.org/uniprot/G8ZXZ9 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/4950:TDEL_0A03000 ^@ http://purl.uniprot.org/uniprot/G8ZLY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0D05960 ^@ http://purl.uniprot.org/uniprot/G8ZU86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||cytoskeleton http://togogenome.org/gene/4950:TDEL_0C05560 ^@ http://purl.uniprot.org/uniprot/G8ZSF3 ^@ Similarity ^@ Belongs to the COG4 family. http://togogenome.org/gene/4950:TDEL_0B00710 ^@ http://purl.uniprot.org/uniprot/G8ZNK6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/4950:TDEL_0C01940 ^@ http://purl.uniprot.org/uniprot/G8ZRE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus http://togogenome.org/gene/4950:TDEL_0B05150 ^@ http://purl.uniprot.org/uniprot/G8ZPV0 ^@ Subcellular Location Annotation ^@ Mitochondrion intermembrane space http://togogenome.org/gene/4950:TDEL_0D05610 ^@ http://purl.uniprot.org/uniprot/G8ZU51 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0A06980 ^@ http://purl.uniprot.org/uniprot/G8ZN36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC4 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/4950:TDEL_0F04970 ^@ http://purl.uniprot.org/uniprot/G8ZXG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS35 family.|||Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0H03540 ^@ http://purl.uniprot.org/uniprot/G9A019 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family. http://togogenome.org/gene/4950:TDEL_0H04130 ^@ http://purl.uniprot.org/uniprot/G9A078 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0D05560 ^@ http://purl.uniprot.org/uniprot/G8ZU46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. LDAH family.|||Lipid droplet http://togogenome.org/gene/4950:TDEL_0D00140 ^@ http://purl.uniprot.org/uniprot/G8ZSK4 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/4950:TDEL_0D06490 ^@ http://purl.uniprot.org/uniprot/G8ZUD9 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/4950:TDEL_0A04190 ^@ http://purl.uniprot.org/uniprot/G8ZMA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.|||Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B03280 ^@ http://purl.uniprot.org/uniprot/G8ZPB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0B00410 ^@ http://purl.uniprot.org/uniprot/G8ZNH6 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/4950:TDEL_0C03400 ^@ http://purl.uniprot.org/uniprot/G8ZRT7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/4950:TDEL_0A00800 ^@ http://purl.uniprot.org/uniprot/G8ZLB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0E01550 ^@ http://purl.uniprot.org/uniprot/G8ZUV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC3 family.|||Component of the Arp2/3 complex.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/4950:TDEL_0B00310 ^@ http://purl.uniprot.org/uniprot/G8ZNG6 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/4950:TDEL_0H01350 ^@ http://purl.uniprot.org/uniprot/G8ZZF0 ^@ Function|||Similarity ^@ Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis. http://togogenome.org/gene/4950:TDEL_0A04660 ^@ http://purl.uniprot.org/uniprot/G8ZMF4 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/4950:TDEL_0B00550 ^@ http://purl.uniprot.org/uniprot/G8ZNJ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0E05370 ^@ http://purl.uniprot.org/uniprot/G8ZVY6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic GTase family.|||Heterodimer.|||Nucleus|||Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate. http://togogenome.org/gene/4950:TDEL_0F03280 ^@ http://purl.uniprot.org/uniprot/G8ZWZ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0G00170 ^@ http://purl.uniprot.org/uniprot/G8ZYA9 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/4950:TDEL_0A01310 ^@ http://purl.uniprot.org/uniprot/G8ZLG9 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/4950:TDEL_0F02340 ^@ http://purl.uniprot.org/uniprot/G8ZWQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A00610 ^@ http://purl.uniprot.org/uniprot/G8ZL99 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/4950:TDEL_0B04420 ^@ http://purl.uniprot.org/uniprot/G8ZPM7 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0C00130 ^@ http://purl.uniprot.org/uniprot/G8ZQW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oligopeptide OPT transporter family.|||Membrane http://togogenome.org/gene/4950:TDEL_0C05320 ^@ http://purl.uniprot.org/uniprot/G8ZSC9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Cytoplasm|||Endoplasmic reticulum|||Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.|||Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.|||The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.|||The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER. http://togogenome.org/gene/4950:TDEL_0A01340 ^@ http://purl.uniprot.org/uniprot/G8ZLH2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/4950:TDEL_0F01730 ^@ http://purl.uniprot.org/uniprot/G8ZWJ0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/4950:TDEL_0F02790 ^@ http://purl.uniprot.org/uniprot/G8ZWU6 ^@ Similarity ^@ Belongs to the PITHD1 family. http://togogenome.org/gene/4950:TDEL_0B01690 ^@ http://purl.uniprot.org/uniprot/G8ZNV4 ^@ Similarity ^@ Belongs to the RRM CWC2 family. http://togogenome.org/gene/4950:TDEL_0G02390 ^@ http://purl.uniprot.org/uniprot/G8ZYY1 ^@ Similarity ^@ Belongs to the frataxin family. http://togogenome.org/gene/4950:TDEL_0C06320 ^@ http://purl.uniprot.org/uniprot/G8ZQN4 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/4950:TDEL_0A04300 ^@ http://purl.uniprot.org/uniprot/G8ZMB8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/4950:TDEL_0A07210 ^@ http://purl.uniprot.org/uniprot/G8ZN59 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/4950:TDEL_0C02870 ^@ http://purl.uniprot.org/uniprot/G8ZRN4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 19 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D03760 ^@ http://purl.uniprot.org/uniprot/G8ZTL6 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/4950:TDEL_0D01010 ^@ http://purl.uniprot.org/uniprot/G8ZSU1 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/4950:TDEL_0G03010 ^@ http://purl.uniprot.org/uniprot/G8ZXQ1 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/4950:TDEL_0G04820 ^@ http://purl.uniprot.org/uniprot/G8ZY82 ^@ Subcellular Location Annotation ^@ Cell surface http://togogenome.org/gene/4950:TDEL_0A04500 ^@ http://purl.uniprot.org/uniprot/G8ZMD8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TPT transporter family. SLC35D subfamily.|||Cytoplasmic vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homooligomer.|||Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.|||Membrane http://togogenome.org/gene/4950:TDEL_0G01360 ^@ http://purl.uniprot.org/uniprot/G8ZYM8 ^@ Similarity ^@ Belongs to the exportin family. http://togogenome.org/gene/4950:TDEL_0C03930 ^@ http://purl.uniprot.org/uniprot/G8ZRZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0F04400 ^@ http://purl.uniprot.org/uniprot/G8ZXA7 ^@ Similarity ^@ Belongs to the dopey family. http://togogenome.org/gene/4950:TDEL_0F04420 ^@ http://purl.uniprot.org/uniprot/G8ZXA9 ^@ Similarity ^@ Belongs to the VPS37 family. http://togogenome.org/gene/4950:TDEL_0D05840 ^@ http://purl.uniprot.org/uniprot/G8ZU74 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24 family. SPT16 subfamily.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Component of the FACT complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C01880 ^@ http://purl.uniprot.org/uniprot/G8ZRD5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0D04170 ^@ http://purl.uniprot.org/uniprot/G8ZTQ7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 37 family. http://togogenome.org/gene/4950:TDEL_0A05270 ^@ http://purl.uniprot.org/uniprot/G8ZML5 ^@ Function|||Similarity ^@ Belongs to the PanB family.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate. http://togogenome.org/gene/4950:TDEL_0H00480 ^@ http://purl.uniprot.org/uniprot/G8ZZ63 ^@ Similarity ^@ Belongs to the PAPS reductase family. CysH subfamily. http://togogenome.org/gene/4950:TDEL_0E00620 ^@ http://purl.uniprot.org/uniprot/G8ZUL1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL18 family. http://togogenome.org/gene/4950:TDEL_0G00190 ^@ http://purl.uniprot.org/uniprot/G8ZYB1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0C02450 ^@ http://purl.uniprot.org/uniprot/G8ZRJ2 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/4950:TDEL_0E04280 ^@ http://purl.uniprot.org/uniprot/G8ZVM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DCAF13/WDSOF1 family.|||nucleolus http://togogenome.org/gene/4950:TDEL_0F05070 ^@ http://purl.uniprot.org/uniprot/G8ZXH4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D04970 ^@ http://purl.uniprot.org/uniprot/G8ZTY7 ^@ Function|||Similarity ^@ Belongs to the REXO4 family.|||Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs. http://togogenome.org/gene/4950:TDEL_0C06290 ^@ http://purl.uniprot.org/uniprot/G8ZQN1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D01300 ^@ http://purl.uniprot.org/uniprot/G8ZSX0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm|||Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. http://togogenome.org/gene/4950:TDEL_0A07110 ^@ http://purl.uniprot.org/uniprot/G8ZN49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG3 family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0B06770 ^@ http://purl.uniprot.org/uniprot/G8ZQB2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCTP family.|||Involved in protein synthesis. Involved in microtubule stabilization.|||cytoskeleton http://togogenome.org/gene/4950:TDEL_0E05040 ^@ http://purl.uniprot.org/uniprot/G8ZVV3 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/4950:TDEL_0G02370 ^@ http://purl.uniprot.org/uniprot/G8ZYX9 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/4950:TDEL_0C02140 ^@ http://purl.uniprot.org/uniprot/G8ZRG1 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/4950:TDEL_0B00470 ^@ http://purl.uniprot.org/uniprot/G8ZNI2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0C03420 ^@ http://purl.uniprot.org/uniprot/G8ZRT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0H01150 ^@ http://purl.uniprot.org/uniprot/G8ZZD0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0E05350 ^@ http://purl.uniprot.org/uniprot/G8ZVY4 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/4950:TDEL_0A01380 ^@ http://purl.uniprot.org/uniprot/G8ZLH6 ^@ Similarity ^@ Belongs to the SPT2 family. http://togogenome.org/gene/4950:TDEL_0C05310 ^@ http://purl.uniprot.org/uniprot/G8ZSC8 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/4950:TDEL_0G00550 ^@ http://purl.uniprot.org/uniprot/G8ZYE7 ^@ Similarity ^@ Belongs to the EFG1 family. http://togogenome.org/gene/4950:TDEL_0D04610 ^@ http://purl.uniprot.org/uniprot/G8ZTV1 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/4950:TDEL_0E05670 ^@ http://purl.uniprot.org/uniprot/G8ZW16 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 28 family.|||Endoplasmic reticulum|||Heterodimer with ALG14 to form a functional enzyme.|||Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. http://togogenome.org/gene/4950:TDEL_0E02810 ^@ http://purl.uniprot.org/uniprot/G8ZV80 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM5 / TYW2 family.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Mitochondrion matrix|||Monomer.|||Nucleus|||Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. http://togogenome.org/gene/4950:TDEL_0C02670 ^@ http://purl.uniprot.org/uniprot/G8ZRL4 ^@ Function|||Subcellular Location Annotation ^@ Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0F00410 ^@ http://purl.uniprot.org/uniprot/G8ZW58 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. http://togogenome.org/gene/4950:TDEL_0A06120 ^@ http://purl.uniprot.org/uniprot/G8ZMV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG5 family.|||Conjugated with ATG12.|||Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.|||Membrane|||Preautophagosomal structure membrane http://togogenome.org/gene/4950:TDEL_0E03170 ^@ http://purl.uniprot.org/uniprot/G8ZVB6 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/4950:TDEL_0B04640 ^@ http://purl.uniprot.org/uniprot/G8ZPP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0G03330 ^@ http://purl.uniprot.org/uniprot/G8ZXT3 ^@ Similarity ^@ Belongs to the CCDC25 family. http://togogenome.org/gene/4950:TDEL_0C06260 ^@ http://purl.uniprot.org/uniprot/G8ZQM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF2 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G02250 ^@ http://purl.uniprot.org/uniprot/G8ZYW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid/polyamine transporter 2 family.|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0G02610 ^@ http://purl.uniprot.org/uniprot/G8ZZ03 ^@ Similarity ^@ Belongs to the prokaryotic/mitochondrial release factor family. http://togogenome.org/gene/4950:TDEL_0H00450 ^@ http://purl.uniprot.org/uniprot/G8ZZ60 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D00430 ^@ http://purl.uniprot.org/uniprot/G8ZSN3 ^@ Similarity ^@ Belongs to the homoserine dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0E03290 ^@ http://purl.uniprot.org/uniprot/G8ZVC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 20 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A02370 ^@ http://purl.uniprot.org/uniprot/G8ZLS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP25 family.|||Mitochondrial mRNA stabilization factor.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0C00730 ^@ http://purl.uniprot.org/uniprot/G8ZR20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E04110 ^@ http://purl.uniprot.org/uniprot/G8ZVL0 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/4950:TDEL_0F00340 ^@ http://purl.uniprot.org/uniprot/G8ZW51 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D01970 ^@ http://purl.uniprot.org/uniprot/G8ZT37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TIM54 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0C04520 ^@ http://purl.uniprot.org/uniprot/G8ZS49 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0E01350 ^@ http://purl.uniprot.org/uniprot/G8ZUT4 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/4950:TDEL_0E01260 ^@ http://purl.uniprot.org/uniprot/G8ZUS5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/4950:TDEL_0E02970 ^@ http://purl.uniprot.org/uniprot/G8ZV96 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 21 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A01940 ^@ http://purl.uniprot.org/uniprot/G8ZLN2 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/4950:TDEL_0B06480 ^@ http://purl.uniprot.org/uniprot/G8ZQ83 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CLU family.|||Cytoplasm|||May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.|||mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. http://togogenome.org/gene/4950:TDEL_0C05300 ^@ http://purl.uniprot.org/uniprot/G8ZSC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SHE3 family.|||Endoplasmic reticulum membrane|||RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Required for the delivery of cortical endoplasmic reticulum into the emerging bud. http://togogenome.org/gene/4950:TDEL_0D05090 ^@ http://purl.uniprot.org/uniprot/G8ZTZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B06510 ^@ http://purl.uniprot.org/uniprot/G8ZQ86 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/4950:TDEL_0F02450 ^@ http://purl.uniprot.org/uniprot/G8ZWR2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the casein kinase 2 subunit beta family.|||Regulatory subunit of casein kinase II/CK2 (By similarity). As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.|||Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/4950:TDEL_0A02180 ^@ http://purl.uniprot.org/uniprot/G8ZLQ6 ^@ Function|||Similarity ^@ Belongs to the SPG4 family.|||Stationary phase-essential protein not required for growth on nonfermentable carbon sources. http://togogenome.org/gene/4950:TDEL_0E05000 ^@ http://purl.uniprot.org/uniprot/G8ZVU9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aldolase class II family. MtnB subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0E00720 ^@ http://purl.uniprot.org/uniprot/G8ZUM1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0A03620 ^@ http://purl.uniprot.org/uniprot/G8ZM50 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/4950:TDEL_0D02600 ^@ http://purl.uniprot.org/uniprot/G8ZTA0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. http://togogenome.org/gene/4950:TDEL_0F05230 ^@ http://purl.uniprot.org/uniprot/G8ZXJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARV1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.|||Membrane|||Regulates also the sphingolipid metabolism. http://togogenome.org/gene/4950:TDEL_0D03410 ^@ http://purl.uniprot.org/uniprot/G8ZTI1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/4950:TDEL_0B02940 ^@ http://purl.uniprot.org/uniprot/G8ZP79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0C01620 ^@ http://purl.uniprot.org/uniprot/G8ZRA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Nucleus|||Required both for recombination and for the repair of DNA damage caused by X-rays. http://togogenome.org/gene/4950:TDEL_0G00320 ^@ http://purl.uniprot.org/uniprot/G8ZYC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit C family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0E04900 ^@ http://purl.uniprot.org/uniprot/G8ZVT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ELP2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0G03050 ^@ http://purl.uniprot.org/uniprot/G8ZXQ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SWP1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/4950:TDEL_0D03100 ^@ http://purl.uniprot.org/uniprot/G8ZTF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF beta subunit family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E00120 ^@ http://purl.uniprot.org/uniprot/G8ZUG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0F05640 ^@ http://purl.uniprot.org/uniprot/G8ZXN1 ^@ Similarity ^@ Belongs to the MNN1/MNT family. http://togogenome.org/gene/4950:TDEL_0A04920 ^@ http://purl.uniprot.org/uniprot/G8ZMI0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/4950:TDEL_0E05440 ^@ http://purl.uniprot.org/uniprot/G8ZVZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. SAR1 family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/4950:TDEL_0D06300 ^@ http://purl.uniprot.org/uniprot/G8ZUC0 ^@ Similarity ^@ Belongs to the APC10 family. http://togogenome.org/gene/4950:TDEL_0G04830 ^@ http://purl.uniprot.org/uniprot/G8ZY83 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0F00380 ^@ http://purl.uniprot.org/uniprot/G8ZW55 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II.|||Cytoplasm|||Nucleus|||Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/4950:TDEL_0B07500 ^@ http://purl.uniprot.org/uniprot/G8ZQI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase d subunit family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0E01280 ^@ http://purl.uniprot.org/uniprot/G8ZUS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the REI1 family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0F02890 ^@ http://purl.uniprot.org/uniprot/G8ZWV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase PH family.|||nucleolus http://togogenome.org/gene/4950:TDEL_0H03500 ^@ http://purl.uniprot.org/uniprot/G9A015 ^@ Function|||Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). http://togogenome.org/gene/4950:TDEL_0G00380 ^@ http://purl.uniprot.org/uniprot/G8ZYD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 17 family.|||cell wall http://togogenome.org/gene/4950:TDEL_0A04100 ^@ http://purl.uniprot.org/uniprot/G8ZM98 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. LCMT family.|||Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. http://togogenome.org/gene/4950:TDEL_0C00820 ^@ http://purl.uniprot.org/uniprot/G8ZR29 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/4950:TDEL_0A05550 ^@ http://purl.uniprot.org/uniprot/G8ZMP3 ^@ Similarity ^@ Belongs to the IPP isomerase type 1 family. http://togogenome.org/gene/4950:TDEL_0B00230 ^@ http://purl.uniprot.org/uniprot/G8ZNF8 ^@ Similarity ^@ Belongs to the NADH dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0C06380 ^@ http://purl.uniprot.org/uniprot/G8ZQP0 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. http://togogenome.org/gene/4950:TDEL_0F02310 ^@ http://purl.uniprot.org/uniprot/G8ZWP8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.|||Cell membrane|||The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses. http://togogenome.org/gene/4950:TDEL_0A07050 ^@ http://purl.uniprot.org/uniprot/G8ZN43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BBP1 family.|||Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication. Connects the central plaque of the SPB with the half-bridge. Required for proper localization of CDC5 at the SPB and for proper M-phase progression.|||spindle pole body http://togogenome.org/gene/4950:TDEL_0G01590 ^@ http://purl.uniprot.org/uniprot/G8ZYQ1 ^@ Similarity ^@ Belongs to the NAD kinase family. http://togogenome.org/gene/4950:TDEL_0D00790 ^@ http://purl.uniprot.org/uniprot/G8ZSR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG8 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0H03020 ^@ http://purl.uniprot.org/uniprot/G8ZZW7 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/4950:TDEL_0D02710 ^@ http://purl.uniprot.org/uniprot/G8ZTB1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0G03870 ^@ http://purl.uniprot.org/uniprot/G8ZXY7 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. http://togogenome.org/gene/4950:TDEL_0E04750 ^@ http://purl.uniprot.org/uniprot/G8ZVS4 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/4950:TDEL_0C06490 ^@ http://purl.uniprot.org/uniprot/G8ZQQ1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. http://togogenome.org/gene/4950:TDEL_0F03930 ^@ http://purl.uniprot.org/uniprot/G8ZX60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GEP5 family.|||Essential for respiratory growth and required for maintenance of mtDNA. Required for cell survival in the absence of prohibitins.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0A06230 ^@ http://purl.uniprot.org/uniprot/G8ZMW1 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/4950:TDEL_0G01890 ^@ http://purl.uniprot.org/uniprot/G8ZYT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family.|||Nucleus matrix|||cytoskeleton http://togogenome.org/gene/4950:TDEL_0D03950 ^@ http://purl.uniprot.org/uniprot/G8ZTN5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/4950:TDEL_0C05930 ^@ http://purl.uniprot.org/uniprot/G8ZSJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL46 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0E00490 ^@ http://purl.uniprot.org/uniprot/G8ZUJ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GST superfamily.|||Homodimer.|||Plays an important role in the cellular response to the nitrogen source. http://togogenome.org/gene/4950:TDEL_0C01500 ^@ http://purl.uniprot.org/uniprot/G8ZR97 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/4950:TDEL_0E03040 ^@ http://purl.uniprot.org/uniprot/G8ZVA3 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/4950:TDEL_0D02930 ^@ http://purl.uniprot.org/uniprot/G8ZTD3 ^@ Similarity ^@ Belongs to the TACO1 family. http://togogenome.org/gene/4950:TDEL_0F04760 ^@ http://purl.uniprot.org/uniprot/G8ZXE3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 81 family. http://togogenome.org/gene/4950:TDEL_0D02890 ^@ http://purl.uniprot.org/uniprot/G8ZTC9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/4950:TDEL_0G02200 ^@ http://purl.uniprot.org/uniprot/G8ZYW2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrion-specific ribosomal protein mS23 family.|||Component of the mitochondrial small ribosomal subunit.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0D04250 ^@ http://purl.uniprot.org/uniprot/G8ZTR5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAF1 family.|||Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.|||Nucleus http://togogenome.org/gene/4950:TDEL_0H00960 ^@ http://purl.uniprot.org/uniprot/G8ZZB1 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/4950:TDEL_0D03940 ^@ http://purl.uniprot.org/uniprot/G8ZTN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Membrane http://togogenome.org/gene/4950:TDEL_0C05460 ^@ http://purl.uniprot.org/uniprot/G8ZSE3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLX9 family.|||Interacts with the 35S, 23S and 20S pre-rRNAs and with the U3 snoRNA.|||Involved in ribosome biogenesis. Required for normal pre-rRNA processing in internal transcribed spacer 1 (ITS1). May be involved in the movements of the replication forks.|||nucleolus http://togogenome.org/gene/4950:TDEL_0E04170 ^@ http://purl.uniprot.org/uniprot/G8ZVL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX16 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0D02460 ^@ http://purl.uniprot.org/uniprot/G8ZT86 ^@ Similarity ^@ In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. http://togogenome.org/gene/4950:TDEL_0G01860 ^@ http://purl.uniprot.org/uniprot/G8ZYS8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0H00290 ^@ http://purl.uniprot.org/uniprot/G8ZZ44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG13 family. Fungi subfamily.|||Preautophagosomal structure http://togogenome.org/gene/4950:TDEL_0B01700 ^@ http://purl.uniprot.org/uniprot/G8ZNV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/4950:TDEL_0C04840 ^@ http://purl.uniprot.org/uniprot/G8ZS81 ^@ Similarity ^@ Belongs to the FES1 family. http://togogenome.org/gene/4950:TDEL_0A04510 ^@ http://purl.uniprot.org/uniprot/G8ZMD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPC family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A06800 ^@ http://purl.uniprot.org/uniprot/G8ZN18 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/4950:TDEL_0D02190 ^@ http://purl.uniprot.org/uniprot/G8ZT59 ^@ Similarity ^@ Belongs to the PHP hydrolase family. HisK subfamily. http://togogenome.org/gene/4950:TDEL_0G02170 ^@ http://purl.uniprot.org/uniprot/G8ZYV9 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/4950:TDEL_0E04220 ^@ http://purl.uniprot.org/uniprot/G8ZVM1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0B02120 ^@ http://purl.uniprot.org/uniprot/G8ZNZ7 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. http://togogenome.org/gene/4950:TDEL_0C00150 ^@ http://purl.uniprot.org/uniprot/G8ZQW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D00740 ^@ http://purl.uniprot.org/uniprot/G8ZSR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMG-CoA reductase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0C00420 ^@ http://purl.uniprot.org/uniprot/G8ZQY9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FYV7 family.|||Involved in the processing of the 20S pre-rRNA.|||nucleolus http://togogenome.org/gene/4950:TDEL_0H04380 ^@ http://purl.uniprot.org/uniprot/G9A0A3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-22 family.|||Involved in peroxisome biogenesis.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/4950:TDEL_0F03450 ^@ http://purl.uniprot.org/uniprot/G8ZX12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT6 family.|||Nucleus|||Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. http://togogenome.org/gene/4950:TDEL_0D05700 ^@ http://purl.uniprot.org/uniprot/G8ZU60 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0H00240 ^@ http://purl.uniprot.org/uniprot/G8ZZ39 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E03840 ^@ http://purl.uniprot.org/uniprot/G8ZVI3 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/4950:TDEL_0H00910 ^@ http://purl.uniprot.org/uniprot/G8ZZA6 ^@ Similarity ^@ Belongs to the glycosyltransferase 15 family. http://togogenome.org/gene/4950:TDEL_0C03700 ^@ http://purl.uniprot.org/uniprot/G8ZRW7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0A05770 ^@ http://purl.uniprot.org/uniprot/G8ZMR5 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/4950:TDEL_0C03590 ^@ http://purl.uniprot.org/uniprot/G8ZRV6 ^@ Function|||Similarity ^@ Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/4950:TDEL_0H00130 ^@ http://purl.uniprot.org/uniprot/G8ZZ28 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0H01390 ^@ http://purl.uniprot.org/uniprot/G8ZZF4 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily. http://togogenome.org/gene/4950:TDEL_0F04390 ^@ http://purl.uniprot.org/uniprot/G8ZXA6 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/4950:TDEL_0B07250 ^@ http://purl.uniprot.org/uniprot/G8ZQG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AEP1 family.|||Mitochondrion|||Required for translation of the mitochondrial OLI1 transcript encoding subunit 9 of mitochondrial ATP synthase. http://togogenome.org/gene/4950:TDEL_0D04790 ^@ http://purl.uniprot.org/uniprot/G8ZTW9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SDHAF2 family.|||Interacts with the flavoprotein subunit within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer. http://togogenome.org/gene/4950:TDEL_0G03180 ^@ http://purl.uniprot.org/uniprot/G8ZXR8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family. http://togogenome.org/gene/4950:TDEL_0F03630 ^@ http://purl.uniprot.org/uniprot/G8ZX30 ^@ Similarity ^@ Belongs to the taffazin family. http://togogenome.org/gene/4950:TDEL_0C04730 ^@ http://purl.uniprot.org/uniprot/G8ZS70 ^@ Similarity ^@ Belongs to the acetyltransferase family. MAK3 subfamily. http://togogenome.org/gene/4950:TDEL_0A07590 ^@ http://purl.uniprot.org/uniprot/G8ZN97 ^@ Similarity ^@ In the C-terminal section; belongs to the anthranilate synthase component I family. http://togogenome.org/gene/4950:TDEL_0D06370 ^@ http://purl.uniprot.org/uniprot/G8ZUC7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily. http://togogenome.org/gene/4950:TDEL_0C00330 ^@ http://purl.uniprot.org/uniprot/G8ZQY0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/4950:TDEL_0H04000 ^@ http://purl.uniprot.org/uniprot/G9A065 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/4950:TDEL_0A03040 ^@ http://purl.uniprot.org/uniprot/G8ZLZ2 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/4950:TDEL_0E04080 ^@ http://purl.uniprot.org/uniprot/G8ZVK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MPP10 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/4950:TDEL_0E00590 ^@ http://purl.uniprot.org/uniprot/G8ZUK8 ^@ Function ^@ Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs. http://togogenome.org/gene/4950:TDEL_0F03730 ^@ http://purl.uniprot.org/uniprot/G8ZX40 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/4950:TDEL_0B02010 ^@ http://purl.uniprot.org/uniprot/G8ZNY6 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/4950:TDEL_0E00840 ^@ http://purl.uniprot.org/uniprot/G8ZUN3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0G01550 ^@ http://purl.uniprot.org/uniprot/G8ZYP7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0E03310 ^@ http://purl.uniprot.org/uniprot/G8ZVD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/4950:TDEL_0C02470 ^@ http://purl.uniprot.org/uniprot/G8ZRJ4 ^@ Similarity ^@ Belongs to the putative lipase ROG1 family. http://togogenome.org/gene/4950:TDEL_0F04190 ^@ http://purl.uniprot.org/uniprot/G8ZX86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC45 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B02230 ^@ http://purl.uniprot.org/uniprot/G8ZP08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A05280 ^@ http://purl.uniprot.org/uniprot/G8ZML6 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. http://togogenome.org/gene/4950:TDEL_0C05100 ^@ http://purl.uniprot.org/uniprot/G8ZSA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C01670 ^@ http://purl.uniprot.org/uniprot/G8ZRB4 ^@ Similarity ^@ Belongs to the RICTOR family. http://togogenome.org/gene/4950:TDEL_0B06030 ^@ http://purl.uniprot.org/uniprot/G8ZQ38 ^@ Similarity ^@ Belongs to the DCC1 family. http://togogenome.org/gene/4950:TDEL_0A05250 ^@ http://purl.uniprot.org/uniprot/G8ZML3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP4 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0B06490 ^@ http://purl.uniprot.org/uniprot/G8ZQ84 ^@ Similarity ^@ Belongs to the polyprenol kinase family. http://togogenome.org/gene/4950:TDEL_0A00410 ^@ http://purl.uniprot.org/uniprot/G8ZL79 ^@ Similarity ^@ Belongs to the WD repeat RTC1 family. http://togogenome.org/gene/4950:TDEL_0G02730 ^@ http://purl.uniprot.org/uniprot/G8ZZ15 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Homodimer.|||Mitochondrion|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. http://togogenome.org/gene/4950:TDEL_0H03110 ^@ http://purl.uniprot.org/uniprot/G8ZZX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMP52 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/4950:TDEL_0D03370 ^@ http://purl.uniprot.org/uniprot/G8ZTH7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ALG14 family.|||Endoplasmic reticulum membrane|||Heterodimer with ALG13 to form a functional enzyme.|||Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.|||Membrane|||Nucleus membrane http://togogenome.org/gene/4950:TDEL_0B04810 ^@ http://purl.uniprot.org/uniprot/G8ZPR6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/4950:TDEL_0B03840 ^@ http://purl.uniprot.org/uniprot/G8ZPG9 ^@ Function|||Similarity ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37. http://togogenome.org/gene/4950:TDEL_0C06140 ^@ http://purl.uniprot.org/uniprot/G8ZQL6 ^@ Similarity ^@ Belongs to the IST1 family. http://togogenome.org/gene/4950:TDEL_0E03850 ^@ http://purl.uniprot.org/uniprot/G8ZVI4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/4950:TDEL_0B04660 ^@ http://purl.uniprot.org/uniprot/G8ZPQ1 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/4950:TDEL_0H00680 ^@ http://purl.uniprot.org/uniprot/G8ZZ83 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 17 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D02940 ^@ http://purl.uniprot.org/uniprot/G8ZTD4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase F subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0A03320 ^@ http://purl.uniprot.org/uniprot/G8ZM20 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPF family.|||Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).|||Interacts with EME1.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G02710 ^@ http://purl.uniprot.org/uniprot/G8ZZ13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E04000 ^@ http://purl.uniprot.org/uniprot/G8ZVJ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0C06620 ^@ http://purl.uniprot.org/uniprot/G8ZQR4 ^@ Cofactor|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/4950:TDEL_0B07620 ^@ http://purl.uniprot.org/uniprot/G8ZQJ7 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.|||Binds 1 Mg(2+) ion per monomer.|||Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D06220 ^@ http://purl.uniprot.org/uniprot/G8ZUB2 ^@ Function|||Similarity ^@ Belongs to the SEC15 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/4950:TDEL_0A01200 ^@ http://purl.uniprot.org/uniprot/G8ZLF8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS3 family. http://togogenome.org/gene/4950:TDEL_0E02470 ^@ http://purl.uniprot.org/uniprot/G8ZV46 ^@ Similarity ^@ Belongs to the TCF25 family. http://togogenome.org/gene/4950:TDEL_0D04400 ^@ http://purl.uniprot.org/uniprot/G8ZTT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A05100 ^@ http://purl.uniprot.org/uniprot/G8ZMJ8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/4950:TDEL_0B07380 ^@ http://purl.uniprot.org/uniprot/G8ZQH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0E04620 ^@ http://purl.uniprot.org/uniprot/G8ZVR1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/4950:TDEL_0A05330 ^@ http://purl.uniprot.org/uniprot/G8ZMM1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NPL4 family.|||Endoplasmic reticulum membrane|||Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway.|||Membrane|||Nucleus membrane|||perinuclear region http://togogenome.org/gene/4950:TDEL_0D04140 ^@ http://purl.uniprot.org/uniprot/G8ZTQ4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/4950:TDEL_0B07270 ^@ http://purl.uniprot.org/uniprot/G8ZQG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||cytoskeleton http://togogenome.org/gene/4950:TDEL_0H03100 ^@ http://purl.uniprot.org/uniprot/G8ZZX5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/4950:TDEL_0D02490 ^@ http://purl.uniprot.org/uniprot/G8ZT89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D06560 ^@ http://purl.uniprot.org/uniprot/G8ZUE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0B05500 ^@ http://purl.uniprot.org/uniprot/G8ZPY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0A05480 ^@ http://purl.uniprot.org/uniprot/G8ZMN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 1 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B00200 ^@ http://purl.uniprot.org/uniprot/G8ZNF5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/4950:TDEL_0F00140 ^@ http://purl.uniprot.org/uniprot/G8ZW31 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/4950:TDEL_0A07540 ^@ http://purl.uniprot.org/uniprot/G8ZN92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL49 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0F05130 ^@ http://purl.uniprot.org/uniprot/G8ZXI0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/4950:TDEL_0H03520 ^@ http://purl.uniprot.org/uniprot/G9A017 ^@ Similarity|||Subunit ^@ Belongs to the SIL1 family.|||Interacts with KAR2. http://togogenome.org/gene/4950:TDEL_0D04010 ^@ http://purl.uniprot.org/uniprot/G8ZTP1 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/4950:TDEL_0F01900 ^@ http://purl.uniprot.org/uniprot/G8ZWK7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0F01680 ^@ http://purl.uniprot.org/uniprot/G8ZWI5 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/4950:TDEL_0G02090 ^@ http://purl.uniprot.org/uniprot/G8ZYV1 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/4950:TDEL_0C04420 ^@ http://purl.uniprot.org/uniprot/G8ZS39 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/4950:TDEL_0B05940 ^@ http://purl.uniprot.org/uniprot/G8ZQ29 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily. http://togogenome.org/gene/4950:TDEL_0G00790 ^@ http://purl.uniprot.org/uniprot/G8ZYH1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 6-phosphogluconate dehydrogenase family.|||Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.|||Homodimer. http://togogenome.org/gene/4950:TDEL_0F02670 ^@ http://purl.uniprot.org/uniprot/G8ZWT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uricase family.|||Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.|||Peroxisome http://togogenome.org/gene/4950:TDEL_0H03390 ^@ http://purl.uniprot.org/uniprot/G9A004 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0B02440 ^@ http://purl.uniprot.org/uniprot/G8ZP29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D04510 ^@ http://purl.uniprot.org/uniprot/G8ZTU1 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/4950:TDEL_0C05220 ^@ http://purl.uniprot.org/uniprot/G8ZSB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A01280 ^@ http://purl.uniprot.org/uniprot/G8ZLG6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK3 subfamily.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.|||Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.|||Mitochondrion matrix|||Monomer. http://togogenome.org/gene/4950:TDEL_0F03100 ^@ http://purl.uniprot.org/uniprot/G8ZWX7 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/4950:TDEL_0A06870 ^@ http://purl.uniprot.org/uniprot/G8ZN25 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0H03580 ^@ http://purl.uniprot.org/uniprot/G9A023 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0G04310 ^@ http://purl.uniprot.org/uniprot/G8ZY31 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane|||Required for vacuolar protein sorting. http://togogenome.org/gene/4950:TDEL_0E00930 ^@ http://purl.uniprot.org/uniprot/G8ZUP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Membrane http://togogenome.org/gene/4950:TDEL_0E05590 ^@ http://purl.uniprot.org/uniprot/G8ZW08 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/4950:TDEL_0D01620 ^@ http://purl.uniprot.org/uniprot/G8ZT02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC3 subfamily.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B05740 ^@ http://purl.uniprot.org/uniprot/G8ZQ09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C01370 ^@ http://purl.uniprot.org/uniprot/G8ZR84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B03190 ^@ http://purl.uniprot.org/uniprot/G8ZPA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM50 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0C05190 ^@ http://purl.uniprot.org/uniprot/G8ZSB6 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/4950:TDEL_0D05830 ^@ http://purl.uniprot.org/uniprot/G8ZU73 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin heavy chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||Membrane|||coated pit http://togogenome.org/gene/4950:TDEL_0B02490 ^@ http://purl.uniprot.org/uniprot/G8ZP34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/4950:TDEL_0A06250 ^@ http://purl.uniprot.org/uniprot/G8ZMW3 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family. http://togogenome.org/gene/4950:TDEL_0F02850 ^@ http://purl.uniprot.org/uniprot/G8ZWV2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0G02460 ^@ http://purl.uniprot.org/uniprot/G8ZYY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 5 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A01530 ^@ http://purl.uniprot.org/uniprot/G8ZLJ1 ^@ Similarity ^@ Belongs to the COG3 family. http://togogenome.org/gene/4950:TDEL_0E03540 ^@ http://purl.uniprot.org/uniprot/G8ZVF3 ^@ Similarity ^@ Belongs to the peptidase S9B family. http://togogenome.org/gene/4950:TDEL_0B07200 ^@ http://purl.uniprot.org/uniprot/G8ZQF5 ^@ Function|||Subcellular Location Annotation ^@ Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0B07260 ^@ http://purl.uniprot.org/uniprot/G8ZQG1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAR5 family.|||Endoplasmic reticulum membrane|||Nucleus membrane|||Required for nuclear membrane fusion during karyogamy. http://togogenome.org/gene/4950:TDEL_0F02440 ^@ http://purl.uniprot.org/uniprot/G8ZWR1 ^@ Similarity ^@ Belongs to the HscB family. http://togogenome.org/gene/4950:TDEL_0C03890 ^@ http://purl.uniprot.org/uniprot/G8ZRY6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.|||Belongs to the COG6 family.|||Component of the conserved oligomeric Golgi complex.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0D00340 ^@ http://purl.uniprot.org/uniprot/G8ZSM4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/4950:TDEL_0C05610 ^@ http://purl.uniprot.org/uniprot/G8ZSF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/4950:TDEL_0G00660 ^@ http://purl.uniprot.org/uniprot/G8ZYF8 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/4950:TDEL_0B01190 ^@ http://purl.uniprot.org/uniprot/G8ZNQ4 ^@ Similarity|||Subunit ^@ Belongs to the EXO5 family.|||Monomer. http://togogenome.org/gene/4950:TDEL_0E01130 ^@ http://purl.uniprot.org/uniprot/G8ZUR2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fungal cytochrome c oxidase subunit 7a family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0B07510 ^@ http://purl.uniprot.org/uniprot/G8ZQI6 ^@ Similarity ^@ Belongs to the DNA2/NAM7 helicase family. http://togogenome.org/gene/4950:TDEL_0C06830 ^@ http://purl.uniprot.org/uniprot/G8ZQT5 ^@ Similarity ^@ Belongs to the RPAP1 family. http://togogenome.org/gene/4950:TDEL_0B01120 ^@ http://purl.uniprot.org/uniprot/G8ZNP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNU66/SART1 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0F02050 ^@ http://purl.uniprot.org/uniprot/G8ZWM2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL19 family. http://togogenome.org/gene/4950:TDEL_0E00110 ^@ http://purl.uniprot.org/uniprot/G8ZUG0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/4950:TDEL_0E02650 ^@ http://purl.uniprot.org/uniprot/G8ZV64 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/4950:TDEL_0G01810 ^@ http://purl.uniprot.org/uniprot/G8ZYS3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0E00200 ^@ http://purl.uniprot.org/uniprot/G8ZUG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A06770 ^@ http://purl.uniprot.org/uniprot/G8ZN15 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/4950:TDEL_0B02740 ^@ http://purl.uniprot.org/uniprot/G8ZP59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||cis-Golgi network http://togogenome.org/gene/4950:TDEL_0C03770 ^@ http://purl.uniprot.org/uniprot/G8ZRX4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRQ/QCR8 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0F01840 ^@ http://purl.uniprot.org/uniprot/G8ZWK1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the fungal TPase family.|||First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.|||Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E00570 ^@ http://purl.uniprot.org/uniprot/G8ZUK6 ^@ Function|||Similarity ^@ Belongs to the methyltransferase TRM13 family.|||tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). http://togogenome.org/gene/4950:TDEL_0E05570 ^@ http://purl.uniprot.org/uniprot/G8ZW06 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/4950:TDEL_0D03860 ^@ http://purl.uniprot.org/uniprot/G8ZTM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DASH complex DAD1 family.|||Nucleus|||kinetochore|||spindle http://togogenome.org/gene/4950:TDEL_0D00560 ^@ http://purl.uniprot.org/uniprot/G8ZSP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM31/MDM32 family.|||Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0B01950 ^@ http://purl.uniprot.org/uniprot/G8ZNY0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK2 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Mitochondrion intermembrane space|||Monomer.|||cytosol http://togogenome.org/gene/4950:TDEL_0D04450 ^@ http://purl.uniprot.org/uniprot/G8ZTT5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/4950:TDEL_0C04220 ^@ http://purl.uniprot.org/uniprot/G8ZS19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0A07550 ^@ http://purl.uniprot.org/uniprot/G8ZN93 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/4950:TDEL_0B07100 ^@ http://purl.uniprot.org/uniprot/G8ZQE5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/4950:TDEL_0C01040 ^@ http://purl.uniprot.org/uniprot/G8ZR51 ^@ Similarity ^@ Belongs to the NEMF family. http://togogenome.org/gene/4950:TDEL_0A03640 ^@ http://purl.uniprot.org/uniprot/G8ZM52 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D03420 ^@ http://purl.uniprot.org/uniprot/G8ZTI2 ^@ Similarity|||Subunit ^@ Belongs to the aerobic coproporphyrinogen-III oxidase family.|||Homodimer. http://togogenome.org/gene/4950:TDEL_0C06070 ^@ http://purl.uniprot.org/uniprot/G8ZQK9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0A05830 ^@ http://purl.uniprot.org/uniprot/G8ZMS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the activator 1 large subunit family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E04230 ^@ http://purl.uniprot.org/uniprot/G8ZVM2 ^@ Function|||Similarity ^@ Belongs to the adenylyl cyclase class-3 family.|||Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP. http://togogenome.org/gene/4950:TDEL_0F01960 ^@ http://purl.uniprot.org/uniprot/G8ZWL3 ^@ Similarity ^@ Belongs to the SELO family. http://togogenome.org/gene/4950:TDEL_0C05470 ^@ http://purl.uniprot.org/uniprot/G8ZSE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom20 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/4950:TDEL_0B05410 ^@ http://purl.uniprot.org/uniprot/G8ZPX6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup85 family.|||Component of the nuclear pore complex (NPC).|||Functions as a component of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/4950:TDEL_0A07530 ^@ http://purl.uniprot.org/uniprot/G8ZN91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0C03910 ^@ http://purl.uniprot.org/uniprot/G8ZRY8 ^@ Similarity ^@ Belongs to the SHQ1 family. http://togogenome.org/gene/4950:TDEL_0G03550 ^@ http://purl.uniprot.org/uniprot/G8ZXV5 ^@ Function ^@ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.|||Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. http://togogenome.org/gene/4950:TDEL_0E02280 ^@ http://purl.uniprot.org/uniprot/G8ZV27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0H02630 ^@ http://purl.uniprot.org/uniprot/G8ZZS8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0A04460 ^@ http://purl.uniprot.org/uniprot/G8ZMD4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CGI121/TPRKB family.|||Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.|||Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification. http://togogenome.org/gene/4950:TDEL_0C02570 ^@ http://purl.uniprot.org/uniprot/G8ZRK4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space http://togogenome.org/gene/4950:TDEL_0G01070 ^@ http://purl.uniprot.org/uniprot/G8ZYJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0A07470 ^@ http://purl.uniprot.org/uniprot/G8ZN85 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RAD18 family.|||E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.|||Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.|||Nucleus http://togogenome.org/gene/4950:TDEL_0H03450 ^@ http://purl.uniprot.org/uniprot/G9A010 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/4950:TDEL_0H03190 ^@ http://purl.uniprot.org/uniprot/G8ZZY4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C02010 ^@ http://purl.uniprot.org/uniprot/G8ZRE8 ^@ Similarity ^@ Belongs to the CNOT2/3/5 family. http://togogenome.org/gene/4950:TDEL_0G02010 ^@ http://purl.uniprot.org/uniprot/G8ZYU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CASP family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0C04850 ^@ http://purl.uniprot.org/uniprot/G8ZS82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EXO84 family.|||Vesicle|||secretory vesicle http://togogenome.org/gene/4950:TDEL_0D04290 ^@ http://purl.uniprot.org/uniprot/G8ZTR9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H3 family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/4950:TDEL_0A01640 ^@ http://purl.uniprot.org/uniprot/G8ZLK2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSA1 family.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/4950:TDEL_0B04130 ^@ http://purl.uniprot.org/uniprot/G8ZPJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A03190 ^@ http://purl.uniprot.org/uniprot/G8ZM07 ^@ Function|||Similarity ^@ 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).|||Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/4950:TDEL_0E04920 ^@ http://purl.uniprot.org/uniprot/G8ZVU1 ^@ Similarity ^@ Belongs to the cytidylyltransferase family. http://togogenome.org/gene/4950:TDEL_0H03380 ^@ http://purl.uniprot.org/uniprot/G9A003 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acireductone dioxygenase (ARD) family.|||Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.|||Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0B01740 ^@ http://purl.uniprot.org/uniprot/G8ZNV9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL5 family. http://togogenome.org/gene/4950:TDEL_0E05750 ^@ http://purl.uniprot.org/uniprot/G8ZW24 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D02620 ^@ http://purl.uniprot.org/uniprot/G8ZTA2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the profilin family.|||Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.|||Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio. http://togogenome.org/gene/4950:TDEL_0E00140 ^@ http://purl.uniprot.org/uniprot/G8ZUG3 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/4950:TDEL_0D04380 ^@ http://purl.uniprot.org/uniprot/G8ZTS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A03490 ^@ http://purl.uniprot.org/uniprot/G8ZM37 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHE9 family.|||Homooligomer.|||Mitochondrion inner membrane|||Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed. http://togogenome.org/gene/4950:TDEL_0D01700 ^@ http://purl.uniprot.org/uniprot/G8ZT10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Membrane http://togogenome.org/gene/4950:TDEL_0C02160 ^@ http://purl.uniprot.org/uniprot/G8ZRG3 ^@ Similarity ^@ Belongs to the SAS10 family. http://togogenome.org/gene/4950:TDEL_0B01220 ^@ http://purl.uniprot.org/uniprot/G8ZNQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAMP4 family.|||Endoplasmic reticulum membrane|||May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. http://togogenome.org/gene/4950:TDEL_0C01020 ^@ http://purl.uniprot.org/uniprot/G8ZR49 ^@ Cofactor|||Similarity ^@ Belongs to the sirtuin family. Class I subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/4950:TDEL_0F03420 ^@ http://purl.uniprot.org/uniprot/G8ZX09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF1 family.|||Mitochondrion inner membrane|||Probably involved in the biogenesis of the COX complex. http://togogenome.org/gene/4950:TDEL_0H02190 ^@ http://purl.uniprot.org/uniprot/G8ZZN4 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/4950:TDEL_0E04320 ^@ http://purl.uniprot.org/uniprot/G8ZVN1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0A05660 ^@ http://purl.uniprot.org/uniprot/G8ZMQ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B07390 ^@ http://purl.uniprot.org/uniprot/G8ZQH4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/4950:TDEL_0E00670 ^@ http://purl.uniprot.org/uniprot/G8ZUL6 ^@ Similarity ^@ Belongs to the DNA polymerase type-B-like family. http://togogenome.org/gene/4950:TDEL_0F04600 ^@ http://purl.uniprot.org/uniprot/G8ZXC7 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/4950:TDEL_0A03910 ^@ http://purl.uniprot.org/uniprot/G8ZM79 ^@ Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family. http://togogenome.org/gene/4950:TDEL_0D01890 ^@ http://purl.uniprot.org/uniprot/G8ZT29 ^@ Similarity ^@ Belongs to the SDHAF4 family. http://togogenome.org/gene/4950:TDEL_0A02580 ^@ http://purl.uniprot.org/uniprot/G8ZLU6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP11 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/4950:TDEL_0B05160 ^@ http://purl.uniprot.org/uniprot/G8ZPV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTU2/NCS2 family.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. http://togogenome.org/gene/4950:TDEL_0E04360 ^@ http://purl.uniprot.org/uniprot/G8ZVN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF alpha subunit family.|||Nucleus|||TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. http://togogenome.org/gene/4950:TDEL_0H00410 ^@ http://purl.uniprot.org/uniprot/G8ZZ56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D03810 ^@ http://purl.uniprot.org/uniprot/G8ZTM1 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/4950:TDEL_0B01300 ^@ http://purl.uniprot.org/uniprot/G8ZNR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INCENP family.|||Nucleus|||spindle http://togogenome.org/gene/4950:TDEL_0E01650 ^@ http://purl.uniprot.org/uniprot/G8ZUW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Membrane http://togogenome.org/gene/4950:TDEL_0G00990 ^@ http://purl.uniprot.org/uniprot/G8ZYJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family.|||Chromosome|||Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C00120 ^@ http://purl.uniprot.org/uniprot/G8ZQV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0F02620 ^@ http://purl.uniprot.org/uniprot/G8ZWS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPC1 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0G02960 ^@ http://purl.uniprot.org/uniprot/G8ZXP6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/4950:TDEL_0G01410 ^@ http://purl.uniprot.org/uniprot/G8ZYN3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0A02140 ^@ http://purl.uniprot.org/uniprot/G8ZLQ2 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0C00180 ^@ http://purl.uniprot.org/uniprot/G8ZQW5 ^@ Function|||Similarity ^@ Belongs to the dihydroxyacetone kinase (DAK) family.|||Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde. http://togogenome.org/gene/4950:TDEL_0A06650 ^@ http://purl.uniprot.org/uniprot/G8ZN03 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat WDR12/YTM1 family.|||Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.|||Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/4950:TDEL_0E02360 ^@ http://purl.uniprot.org/uniprot/G8ZV35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0B04520 ^@ http://purl.uniprot.org/uniprot/G8ZPN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/4950:TDEL_0H02410 ^@ http://purl.uniprot.org/uniprot/G8ZZQ6 ^@ Similarity|||Subunit ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer. http://togogenome.org/gene/4950:TDEL_0G01090 ^@ http://purl.uniprot.org/uniprot/G8ZYK1 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Heterooctamer of 4 alpha and 4 beta chains. http://togogenome.org/gene/4950:TDEL_0B01590 ^@ http://purl.uniprot.org/uniprot/G8ZNU4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/4950:TDEL_0D06260 ^@ http://purl.uniprot.org/uniprot/G8ZUB6 ^@ Function|||Similarity ^@ Belongs to the MnmG family.|||Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. http://togogenome.org/gene/4950:TDEL_0D02050 ^@ http://purl.uniprot.org/uniprot/G8ZT45 ^@ Subcellular Location Annotation ^@ Nucleus|||telomere http://togogenome.org/gene/4950:TDEL_0A05130 ^@ http://purl.uniprot.org/uniprot/G8ZMK1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0G00600 ^@ http://purl.uniprot.org/uniprot/G8ZYF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0B02690 ^@ http://purl.uniprot.org/uniprot/G8ZP54 ^@ Caution|||Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anamorsin family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion intermembrane space|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/4950:TDEL_0C03140 ^@ http://purl.uniprot.org/uniprot/G8ZRR1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/4950:TDEL_0B05870 ^@ http://purl.uniprot.org/uniprot/G8ZQ22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Bud neck http://togogenome.org/gene/4950:TDEL_0G04170 ^@ http://purl.uniprot.org/uniprot/G8ZY17 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/4950:TDEL_0H01700 ^@ http://purl.uniprot.org/uniprot/G8ZZI5 ^@ Function|||Similarity ^@ Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.|||Belongs to the proteasome subunit S1 family. http://togogenome.org/gene/4950:TDEL_0F02150 ^@ http://purl.uniprot.org/uniprot/G8ZWN2 ^@ Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family. http://togogenome.org/gene/4950:TDEL_0B04430 ^@ http://purl.uniprot.org/uniprot/G8ZPM8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.|||Belongs to the peptidase S16 family.|||Homohexamer or homoheptamer. Organized in a ring with a central cavity.|||Mitochondrion matrix http://togogenome.org/gene/4950:TDEL_0B00510 ^@ http://purl.uniprot.org/uniprot/G8ZNI6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AEP2 family.|||Binds to the 5'UTR of the OLI1 mRNA.|||Mitochondrion|||Required for translation of the mitochondrial OLI1 transcript coding for the mitochondrial ATP synthase subunit 9. http://togogenome.org/gene/4950:TDEL_0H02990 ^@ http://purl.uniprot.org/uniprot/G8ZZW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0E05080 ^@ http://purl.uniprot.org/uniprot/G8ZVV7 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) per subunit. http://togogenome.org/gene/4950:TDEL_0E04480 ^@ http://purl.uniprot.org/uniprot/G8ZVP7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0F04620 ^@ http://purl.uniprot.org/uniprot/G8ZXC9 ^@ Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Homodimer. http://togogenome.org/gene/4950:TDEL_0F05120 ^@ http://purl.uniprot.org/uniprot/G8ZXH9 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/4950:TDEL_0F01060 ^@ http://purl.uniprot.org/uniprot/G8ZWC3 ^@ Similarity ^@ Belongs to the CWC26 family. http://togogenome.org/gene/4950:TDEL_0F04450 ^@ http://purl.uniprot.org/uniprot/G8ZXB2 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/4950:TDEL_0B06940 ^@ http://purl.uniprot.org/uniprot/G8ZQC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0C06900 ^@ http://purl.uniprot.org/uniprot/G8ZQU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.|||nucleolus http://togogenome.org/gene/4950:TDEL_0B04290 ^@ http://purl.uniprot.org/uniprot/G8ZPL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RPAP2 family.|||Nucleus|||Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation. http://togogenome.org/gene/4950:TDEL_0E05100 ^@ http://purl.uniprot.org/uniprot/G8ZVV9 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/4950:TDEL_0A02910 ^@ http://purl.uniprot.org/uniprot/G8ZLX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL50 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0E04550 ^@ http://purl.uniprot.org/uniprot/G8ZVQ4 ^@ Cofactor|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.|||Endosome membrane|||Golgi apparatus membrane|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.|||The C2 domains have an essential, but non-catalytic function. They may facilitate interaction with PstB2 and are required for lipid transport function. http://togogenome.org/gene/4950:TDEL_0G04280 ^@ http://purl.uniprot.org/uniprot/G8ZY28 ^@ Similarity ^@ Belongs to the lysophospholipase family. http://togogenome.org/gene/4950:TDEL_0B06820 ^@ http://purl.uniprot.org/uniprot/G8ZQB7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0H00320 ^@ http://purl.uniprot.org/uniprot/G8ZZ47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A07570 ^@ http://purl.uniprot.org/uniprot/G8ZN95 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/4950:TDEL_0A05120 ^@ http://purl.uniprot.org/uniprot/G8ZMK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A05780 ^@ http://purl.uniprot.org/uniprot/G8ZMR6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0F04950 ^@ http://purl.uniprot.org/uniprot/G8ZXG2 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/4950:TDEL_0H01270 ^@ http://purl.uniprot.org/uniprot/G8ZZE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0D05800 ^@ http://purl.uniprot.org/uniprot/G8ZU70 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/4950:TDEL_0C07040 ^@ http://purl.uniprot.org/uniprot/G8ZQV6 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0D03240 ^@ http://purl.uniprot.org/uniprot/G8ZTG4 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/4950:TDEL_0A00660 ^@ http://purl.uniprot.org/uniprot/G8ZLA4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.|||Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. http://togogenome.org/gene/4950:TDEL_0A06940 ^@ http://purl.uniprot.org/uniprot/G8ZN32 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/4950:TDEL_0C06750 ^@ http://purl.uniprot.org/uniprot/G8ZQS7 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. FKBP2 subfamily. http://togogenome.org/gene/4950:TDEL_0H00760 ^@ http://purl.uniprot.org/uniprot/G8ZZ91 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PAM17 family.|||Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Component of the PAM complex.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0G03630 ^@ http://purl.uniprot.org/uniprot/G8ZXW3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDS23 family.|||Cytoplasm|||Involved in DNA replication and cell separation. http://togogenome.org/gene/4950:TDEL_0B07520 ^@ http://purl.uniprot.org/uniprot/G8ZQI7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0G01030 ^@ http://purl.uniprot.org/uniprot/G8ZYJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2H phosphoesterase superfamily. CPD1 family.|||Golgi apparatus|||Involved in the metabolism of ADP-ribose 1',2'-cyclic phosphate which is produced as a consequence of tRNA splicing. http://togogenome.org/gene/4950:TDEL_0D04190 ^@ http://purl.uniprot.org/uniprot/G8ZTQ9 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/4950:TDEL_0B03760 ^@ http://purl.uniprot.org/uniprot/G8ZPG1 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/4950:TDEL_0C05880 ^@ http://purl.uniprot.org/uniprot/G8ZSI5 ^@ Function|||Similarity ^@ Belongs to the DPH4 family.|||Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. http://togogenome.org/gene/4950:TDEL_0A07650 ^@ http://purl.uniprot.org/uniprot/G8ZNA3 ^@ Similarity ^@ Belongs to the PAT1 family. http://togogenome.org/gene/4950:TDEL_0A02720 ^@ http://purl.uniprot.org/uniprot/G8ZLW0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/4950:TDEL_0B02370 ^@ http://purl.uniprot.org/uniprot/G8ZP22 ^@ Function|||Similarity ^@ Belongs to the TVP38/TMEM64 family.|||Golgi membrane protein involved in vesicular trafficking and spindle migration. http://togogenome.org/gene/4950:TDEL_0F04990 ^@ http://purl.uniprot.org/uniprot/G8ZXG6 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/4950:TDEL_0G04990 ^@ http://purl.uniprot.org/uniprot/G8ZY99 ^@ Subcellular Location Annotation ^@ Cell surface http://togogenome.org/gene/4950:TDEL_0B02650 ^@ http://purl.uniprot.org/uniprot/G8ZP50 ^@ Similarity ^@ Belongs to the MAP65/ASE1 family. http://togogenome.org/gene/4950:TDEL_0D01430 ^@ http://purl.uniprot.org/uniprot/G8ZSY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGW family.|||Endoplasmic reticulum membrane|||Membrane|||Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. http://togogenome.org/gene/4950:TDEL_0D02200 ^@ http://purl.uniprot.org/uniprot/G8ZT60 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/4950:TDEL_0D02430 ^@ http://purl.uniprot.org/uniprot/G8ZT83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A03500 ^@ http://purl.uniprot.org/uniprot/G8ZM38 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/4950:TDEL_0H02610 ^@ http://purl.uniprot.org/uniprot/G8ZZS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC2 subfamily.|||Nucleus http://togogenome.org/gene/4950:TDEL_0F02810 ^@ http://purl.uniprot.org/uniprot/G8ZWU8 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/4950:TDEL_0F01850 ^@ http://purl.uniprot.org/uniprot/G8ZWK2 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/4950:TDEL_0E00520 ^@ http://purl.uniprot.org/uniprot/G8ZUK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SQS1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0F02290 ^@ http://purl.uniprot.org/uniprot/G8ZWP6 ^@ Function|||Similarity ^@ Belongs to the tRNA-intron endonuclease family.|||Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. http://togogenome.org/gene/4950:TDEL_0B00480 ^@ http://purl.uniprot.org/uniprot/G8ZNI3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0H02530 ^@ http://purl.uniprot.org/uniprot/G8ZZR8 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/4950:TDEL_0C02680 ^@ http://purl.uniprot.org/uniprot/G8ZRL5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/4950:TDEL_0C04550 ^@ http://purl.uniprot.org/uniprot/G8ZS52 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/4950:TDEL_0F05170 ^@ http://purl.uniprot.org/uniprot/G8ZXI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0G04970 ^@ http://purl.uniprot.org/uniprot/G8ZY97 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/4950:TDEL_0D00350 ^@ http://purl.uniprot.org/uniprot/G8ZSM5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/4950:TDEL_0E03390 ^@ http://purl.uniprot.org/uniprot/G8ZVD8 ^@ Function|||Subcellular Location Annotation ^@ Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E05330 ^@ http://purl.uniprot.org/uniprot/G8ZVY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP72 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0A02200 ^@ http://purl.uniprot.org/uniprot/G8ZLQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VEL1 family.|||cytosol http://togogenome.org/gene/4950:TDEL_0F02280 ^@ http://purl.uniprot.org/uniprot/G8ZWP5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/4950:TDEL_0A01090 ^@ http://purl.uniprot.org/uniprot/G8ZLE7 ^@ Function|||Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate. http://togogenome.org/gene/4950:TDEL_0C00590 ^@ http://purl.uniprot.org/uniprot/G8ZR06 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/4950:TDEL_0E04030 ^@ http://purl.uniprot.org/uniprot/G8ZVK2 ^@ Subcellular Location Annotation ^@ Membrane|||cell wall http://togogenome.org/gene/4950:TDEL_0B07000 ^@ http://purl.uniprot.org/uniprot/G8ZQD5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0F00960 ^@ http://purl.uniprot.org/uniprot/G8ZWB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.|||nucleolus http://togogenome.org/gene/4950:TDEL_0F05260 ^@ http://purl.uniprot.org/uniprot/G8ZXJ3 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/4950:TDEL_0G02210 ^@ http://purl.uniprot.org/uniprot/G8ZYW3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Membrane http://togogenome.org/gene/4950:TDEL_0D06610 ^@ http://purl.uniprot.org/uniprot/G8ZUF1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0B06270 ^@ http://purl.uniprot.org/uniprot/G8ZQ62 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0A01470 ^@ http://purl.uniprot.org/uniprot/G8ZLI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RRP8 family.|||S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.|||nucleolus http://togogenome.org/gene/4950:TDEL_0C06990 ^@ http://purl.uniprot.org/uniprot/G8ZQV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0E05200 ^@ http://purl.uniprot.org/uniprot/G8ZVW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/4950:TDEL_0H03510 ^@ http://purl.uniprot.org/uniprot/G9A016 ^@ Similarity ^@ Belongs to the OPI10 family. http://togogenome.org/gene/4950:TDEL_0A03960 ^@ http://purl.uniprot.org/uniprot/G8ZM84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Endosome membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0G03540 ^@ http://purl.uniprot.org/uniprot/G8ZXV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 31 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0F04200 ^@ http://purl.uniprot.org/uniprot/G8ZX87 ^@ Similarity ^@ Belongs to the LCL2 family. http://togogenome.org/gene/4950:TDEL_0G04660 ^@ http://purl.uniprot.org/uniprot/G8ZY66 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0F05180 ^@ http://purl.uniprot.org/uniprot/G8ZXI5 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/4950:TDEL_0A02780 ^@ http://purl.uniprot.org/uniprot/G8ZLW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Endosome membrane http://togogenome.org/gene/4950:TDEL_0G03160 ^@ http://purl.uniprot.org/uniprot/G8ZXR6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/4950:TDEL_0C03730 ^@ http://purl.uniprot.org/uniprot/G8ZRX0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0E03700 ^@ http://purl.uniprot.org/uniprot/G8ZVG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NnrD/CARKD family.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0D04800 ^@ http://purl.uniprot.org/uniprot/G8ZTX0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NPC2 family.|||Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.|||Monomer. http://togogenome.org/gene/4950:TDEL_0H00950 ^@ http://purl.uniprot.org/uniprot/G8ZZB0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS21 family.|||Component of the small ribosomal subunit.|||Cytoplasm|||Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability. http://togogenome.org/gene/4950:TDEL_0A05930 ^@ http://purl.uniprot.org/uniprot/G8ZMT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NifU family.|||Mitochondrion matrix|||Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. http://togogenome.org/gene/4950:TDEL_0H04100 ^@ http://purl.uniprot.org/uniprot/G9A075 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily. http://togogenome.org/gene/4950:TDEL_0A07150 ^@ http://purl.uniprot.org/uniprot/G8ZN53 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 9 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G04640 ^@ http://purl.uniprot.org/uniprot/G8ZY64 ^@ Similarity ^@ Belongs to the MYBBP1A family. http://togogenome.org/gene/4950:TDEL_0E02310 ^@ http://purl.uniprot.org/uniprot/G8ZV30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A07080 ^@ http://purl.uniprot.org/uniprot/G8ZN46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ROT1 family.|||Endoplasmic reticulum membrane|||Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies. http://togogenome.org/gene/4950:TDEL_0E02410 ^@ http://purl.uniprot.org/uniprot/G8ZV40 ^@ Similarity ^@ Belongs to the exportin family. http://togogenome.org/gene/4950:TDEL_0C03990 ^@ http://purl.uniprot.org/uniprot/G8ZRZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0D05820 ^@ http://purl.uniprot.org/uniprot/G8ZU72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/4950:TDEL_0B06660 ^@ http://purl.uniprot.org/uniprot/G8ZQA1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the class II fructose-bisphosphate aldolase family.|||Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.|||Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. http://togogenome.org/gene/4950:TDEL_0C03450 ^@ http://purl.uniprot.org/uniprot/G8ZRU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0G04080 ^@ http://purl.uniprot.org/uniprot/G8ZY08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0G02770 ^@ http://purl.uniprot.org/uniprot/G8ZZ19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INP2 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/4950:TDEL_0E01070 ^@ http://purl.uniprot.org/uniprot/G8ZUQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.|||Membrane http://togogenome.org/gene/4950:TDEL_0H00730 ^@ http://purl.uniprot.org/uniprot/G8ZZ88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0C03710 ^@ http://purl.uniprot.org/uniprot/G8ZRW8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/4950:TDEL_0C02300 ^@ http://purl.uniprot.org/uniprot/G8ZRH7 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/4950:TDEL_0E05030 ^@ http://purl.uniprot.org/uniprot/G8ZVV2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF beta-subunit/FixA family.|||Binds 1 AMP per subunit.|||Binds 1 FAD per dimer.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/4950:TDEL_0C00840 ^@ http://purl.uniprot.org/uniprot/G8ZR31 ^@ Similarity ^@ Belongs to the acetyltransferase family. GNA1 subfamily. http://togogenome.org/gene/4950:TDEL_0C01970 ^@ http://purl.uniprot.org/uniprot/G8ZRE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COQ9 family.|||Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0E01560 ^@ http://purl.uniprot.org/uniprot/G8ZUV5 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/4950:TDEL_0D01110 ^@ http://purl.uniprot.org/uniprot/G8ZSV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS2 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0B02800 ^@ http://purl.uniprot.org/uniprot/G8ZP65 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/4950:TDEL_0H00380 ^@ http://purl.uniprot.org/uniprot/G8ZZ53 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX. http://togogenome.org/gene/4950:TDEL_0D05500 ^@ http://purl.uniprot.org/uniprot/G8ZU40 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. http://togogenome.org/gene/4950:TDEL_0A01860 ^@ http://purl.uniprot.org/uniprot/G8ZLM4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DLT1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Required for growth under high-pressure and low-temperature conditions. http://togogenome.org/gene/4950:TDEL_0D04470 ^@ http://purl.uniprot.org/uniprot/G8ZTT7 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/4950:TDEL_0H03490 ^@ http://purl.uniprot.org/uniprot/G9A014 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC5 subfamily.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E01850 ^@ http://purl.uniprot.org/uniprot/G8ZUY4 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/4950:TDEL_0A04850 ^@ http://purl.uniprot.org/uniprot/G8ZMH3 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/4950:TDEL_0D05510 ^@ http://purl.uniprot.org/uniprot/G8ZU41 ^@ Similarity ^@ Belongs to the CBF/MAK21 family. http://togogenome.org/gene/4950:TDEL_0B03530 ^@ http://purl.uniprot.org/uniprot/G8ZPD8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/4950:TDEL_0A02940 ^@ http://purl.uniprot.org/uniprot/G8ZLY2 ^@ Similarity ^@ Belongs to the glycosyltransferase 15 family. http://togogenome.org/gene/4950:TDEL_0E00410 ^@ http://purl.uniprot.org/uniprot/G8ZUJ0 ^@ Similarity ^@ Belongs to the peptidase S8 family. Furin subfamily. http://togogenome.org/gene/4950:TDEL_0D03330 ^@ http://purl.uniprot.org/uniprot/G8ZTH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANKZF1/VMS1 family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0D01680 ^@ http://purl.uniprot.org/uniprot/G8ZT08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family.|||Mitochondrion|||N-acetylglutamate synthase involved in arginine biosynthesis. http://togogenome.org/gene/4950:TDEL_0A05850 ^@ http://purl.uniprot.org/uniprot/G8ZMS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0B04580 ^@ http://purl.uniprot.org/uniprot/G8ZPP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G01050 ^@ http://purl.uniprot.org/uniprot/G8ZYJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDA1 family.|||Required for 60S pre-ribosomal subunits export to the cytoplasm.|||nucleolus http://togogenome.org/gene/4950:TDEL_0F01100 ^@ http://purl.uniprot.org/uniprot/G8ZWC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase g subunit family.|||Membrane http://togogenome.org/gene/4950:TDEL_0F00390 ^@ http://purl.uniprot.org/uniprot/G8ZW56 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PSMG2 family.|||Component of the 20S proteasome chaperone.|||Involved in 20S proteasome assembly. http://togogenome.org/gene/4950:TDEL_0A04560 ^@ http://purl.uniprot.org/uniprot/G8ZME4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.|||Cytoplasm|||Monomer.|||Nucleus|||S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12. http://togogenome.org/gene/4950:TDEL_0H00300 ^@ http://purl.uniprot.org/uniprot/G8ZZ45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycogen debranching enzyme family.|||Cytoplasm|||Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. http://togogenome.org/gene/4950:TDEL_0E04020 ^@ http://purl.uniprot.org/uniprot/G8ZVK1 ^@ Function|||Similarity ^@ Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.|||Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/4950:TDEL_0E05580 ^@ http://purl.uniprot.org/uniprot/G8ZW07 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0A00840 ^@ http://purl.uniprot.org/uniprot/G8ZLC2 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/4950:TDEL_0D06130 ^@ http://purl.uniprot.org/uniprot/G8ZUA3 ^@ Cofactor|||Similarity ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit. http://togogenome.org/gene/4950:TDEL_0H02070 ^@ http://purl.uniprot.org/uniprot/G8ZZM2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/4950:TDEL_0F01340 ^@ http://purl.uniprot.org/uniprot/G8ZWF1 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/4950:TDEL_0B03170 ^@ http://purl.uniprot.org/uniprot/G8ZPA2 ^@ Function|||Similarity ^@ Belongs to the VPS28 family.|||Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. http://togogenome.org/gene/4950:TDEL_0C00370 ^@ http://purl.uniprot.org/uniprot/G8ZQY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YSP2 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0C00780 ^@ http://purl.uniprot.org/uniprot/G8ZR25 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. http://togogenome.org/gene/4950:TDEL_0E01320 ^@ http://purl.uniprot.org/uniprot/G8ZUT1 ^@ Similarity ^@ Belongs to the RAD52 family. http://togogenome.org/gene/4950:TDEL_0D02260 ^@ http://purl.uniprot.org/uniprot/G8ZT66 ^@ Similarity ^@ Belongs to the NADH dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0H02850 ^@ http://purl.uniprot.org/uniprot/G8ZZV0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/4950:TDEL_0F03960 ^@ http://purl.uniprot.org/uniprot/G8ZX63 ^@ Similarity ^@ Belongs to the eIF2D family. http://togogenome.org/gene/4950:TDEL_0E04310 ^@ http://purl.uniprot.org/uniprot/G8ZVN0 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/4950:TDEL_0A07190 ^@ http://purl.uniprot.org/uniprot/G8ZN57 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the glyoxalase I family.|||Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.|||Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. http://togogenome.org/gene/4950:TDEL_0E02130 ^@ http://purl.uniprot.org/uniprot/G8ZV12 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/4950:TDEL_0D04040 ^@ http://purl.uniprot.org/uniprot/G8ZTP4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0B07690 ^@ http://purl.uniprot.org/uniprot/G8ZQK4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0A06470 ^@ http://purl.uniprot.org/uniprot/G8ZMY5 ^@ Similarity ^@ Belongs to the peptidase M28 family. M28B subfamily. http://togogenome.org/gene/4950:TDEL_0F02570 ^@ http://purl.uniprot.org/uniprot/G8ZWS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 63 family.|||Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.|||Endoplasmic reticulum membrane http://togogenome.org/gene/4950:TDEL_0A00870 ^@ http://purl.uniprot.org/uniprot/G8ZLC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RTT106 family.|||Chromosome|||Nucleus http://togogenome.org/gene/4950:TDEL_0E04130 ^@ http://purl.uniprot.org/uniprot/G8ZVL2 ^@ Subunit ^@ The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. http://togogenome.org/gene/4950:TDEL_0D01240 ^@ http://purl.uniprot.org/uniprot/G8ZSW4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HEATR1/UTP10 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/4950:TDEL_0D03510 ^@ http://purl.uniprot.org/uniprot/G8ZTJ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC2 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Component of the origin recognition complex (ORC).|||Nucleus http://togogenome.org/gene/4950:TDEL_0D05810 ^@ http://purl.uniprot.org/uniprot/G8ZU71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/4950:TDEL_0G01570 ^@ http://purl.uniprot.org/uniprot/G8ZYP9 ^@ Similarity ^@ Belongs to the MAD1 family. http://togogenome.org/gene/4950:TDEL_0B02880 ^@ http://purl.uniprot.org/uniprot/G8ZP73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GDT1 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0G04270 ^@ http://purl.uniprot.org/uniprot/G8ZY27 ^@ Similarity ^@ Belongs to the lysophospholipase family. http://togogenome.org/gene/4950:TDEL_0G04520 ^@ http://purl.uniprot.org/uniprot/G8ZY52 ^@ Similarity ^@ Belongs to the NPR2 family. http://togogenome.org/gene/4950:TDEL_0F02940 ^@ http://purl.uniprot.org/uniprot/G8ZWW1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0E04190 ^@ http://purl.uniprot.org/uniprot/G8ZVL8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MMM1 family.|||Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.|||Endoplasmic reticulum membrane|||Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking. http://togogenome.org/gene/4950:TDEL_0F05590 ^@ http://purl.uniprot.org/uniprot/G8ZXM6 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/4950:TDEL_0A04200 ^@ http://purl.uniprot.org/uniprot/G8ZMA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0B02180 ^@ http://purl.uniprot.org/uniprot/G8ZP03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DXO/Dom3Z family.|||Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.|||Nucleus http://togogenome.org/gene/4950:TDEL_0F03020 ^@ http://purl.uniprot.org/uniprot/G8ZWW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SOP4 family.|||Endoplasmic reticulum membrane|||Involved in the export of PMA1, possibly through the monitoring or assisting of PMA1 folding and acquisition of competence to enter vesicles.|||Membrane http://togogenome.org/gene/4950:TDEL_0E05420 ^@ http://purl.uniprot.org/uniprot/G8ZVZ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0B04460 ^@ http://purl.uniprot.org/uniprot/G8ZPN1 ^@ Cofactor|||Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/4950:TDEL_0A06400 ^@ http://purl.uniprot.org/uniprot/G8ZMX8 ^@ Similarity ^@ Belongs to the TMA16 family. http://togogenome.org/gene/4950:TDEL_0D05980 ^@ http://purl.uniprot.org/uniprot/G8ZU88 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/4950:TDEL_0G02310 ^@ http://purl.uniprot.org/uniprot/G8ZYX3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0B01580 ^@ http://purl.uniprot.org/uniprot/G8ZNU3 ^@ Similarity ^@ Belongs to the gluconokinase GntK/GntV family. http://togogenome.org/gene/4950:TDEL_0A07850 ^@ http://purl.uniprot.org/uniprot/G8ZNC3 ^@ Similarity ^@ Belongs to the TRM112 family. http://togogenome.org/gene/4950:TDEL_0F03900 ^@ http://purl.uniprot.org/uniprot/G8ZX57 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/4950:TDEL_0C03860 ^@ http://purl.uniprot.org/uniprot/G8ZRY3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 15 family. http://togogenome.org/gene/4950:TDEL_0H02900 ^@ http://purl.uniprot.org/uniprot/G8ZZV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EST3 family.|||Component of the telomerase complex involved in telomere replication. Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase.|||Nucleus|||telomere http://togogenome.org/gene/4950:TDEL_0G03830 ^@ http://purl.uniprot.org/uniprot/G8ZXY3 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/4950:TDEL_0C05430 ^@ http://purl.uniprot.org/uniprot/G8ZSE0 ^@ Similarity ^@ Belongs to the PHF5 family. http://togogenome.org/gene/4950:TDEL_0B05620 ^@ http://purl.uniprot.org/uniprot/G8ZPZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-catenin family.|||Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.|||Membrane|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0H00170 ^@ http://purl.uniprot.org/uniprot/G8ZZ32 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D01380 ^@ http://purl.uniprot.org/uniprot/G8ZSX8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/4950:TDEL_0B04730 ^@ http://purl.uniprot.org/uniprot/G8ZPQ8 ^@ Function|||Similarity ^@ Belongs to the endosulfine family.|||Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway. http://togogenome.org/gene/4950:TDEL_0A06570 ^@ http://purl.uniprot.org/uniprot/G8ZMZ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/4950:TDEL_0F02090 ^@ http://purl.uniprot.org/uniprot/G8ZWM6 ^@ Similarity ^@ Belongs to the CBF/MAK21 family. http://togogenome.org/gene/4950:TDEL_0H02380 ^@ http://purl.uniprot.org/uniprot/G8ZZQ3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/4950:TDEL_0G02530 ^@ http://purl.uniprot.org/uniprot/G8ZYZ5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/4950:TDEL_0E00890 ^@ http://purl.uniprot.org/uniprot/G8ZUN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LOT5 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G03420 ^@ http://purl.uniprot.org/uniprot/G8ZXU2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MON1/SAND family.|||Prevacuolar compartment membrane|||Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.|||Vacuole membrane|||multivesicular body membrane http://togogenome.org/gene/4950:TDEL_0B02170 ^@ http://purl.uniprot.org/uniprot/G8ZP02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM10 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D05210 ^@ http://purl.uniprot.org/uniprot/G8ZU11 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/4950:TDEL_0A02010 ^@ http://purl.uniprot.org/uniprot/G8ZLN9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/4950:TDEL_0C01120 ^@ http://purl.uniprot.org/uniprot/G8ZR59 ^@ Similarity ^@ Belongs to the patched family. http://togogenome.org/gene/4950:TDEL_0E01530 ^@ http://purl.uniprot.org/uniprot/G8ZUV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/4950:TDEL_0F01320 ^@ http://purl.uniprot.org/uniprot/G8ZWE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid/polyamine transporter 2 family.|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0A01920 ^@ http://purl.uniprot.org/uniprot/G8ZLN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PurH family.|||cytosol http://togogenome.org/gene/4950:TDEL_0G03040 ^@ http://purl.uniprot.org/uniprot/G8ZXQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0C05760 ^@ http://purl.uniprot.org/uniprot/G8ZSH3 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/4950:TDEL_0F00240 ^@ http://purl.uniprot.org/uniprot/G8ZW41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A03440 ^@ http://purl.uniprot.org/uniprot/G8ZM32 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0D06090 ^@ http://purl.uniprot.org/uniprot/G8ZU99 ^@ Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family. http://togogenome.org/gene/4950:TDEL_0A04240 ^@ http://purl.uniprot.org/uniprot/G8ZMB2 ^@ Similarity ^@ Belongs to the putative lipase ROG1 family. http://togogenome.org/gene/4950:TDEL_0A06910 ^@ http://purl.uniprot.org/uniprot/G8ZN29 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/4950:TDEL_0C06080 ^@ http://purl.uniprot.org/uniprot/G8ZQL0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||DNA polymerase II participates in chromosomal DNA replication.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B01320 ^@ http://purl.uniprot.org/uniprot/G8ZNR7 ^@ Similarity ^@ Belongs to the glycosyltransferase 15 family. http://togogenome.org/gene/4950:TDEL_0E03230 ^@ http://purl.uniprot.org/uniprot/G8ZVC2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/4950:TDEL_0A05590 ^@ http://purl.uniprot.org/uniprot/G8ZMP7 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/4950:TDEL_0C00510 ^@ http://purl.uniprot.org/uniprot/G8ZQZ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/4950:TDEL_0A03240 ^@ http://purl.uniprot.org/uniprot/G8ZM12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0C01460 ^@ http://purl.uniprot.org/uniprot/G8ZR93 ^@ Similarity ^@ Belongs to the non-repetitive/WGA-negative nucleoporin family. http://togogenome.org/gene/4950:TDEL_0A07880 ^@ http://purl.uniprot.org/uniprot/G8ZNC6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0C02230 ^@ http://purl.uniprot.org/uniprot/G8ZRH0 ^@ Function|||Similarity ^@ Belongs to the tubulin family.|||Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. http://togogenome.org/gene/4950:TDEL_0A04600 ^@ http://purl.uniprot.org/uniprot/G8ZME8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Membrane http://togogenome.org/gene/4950:TDEL_0E02770 ^@ http://purl.uniprot.org/uniprot/G8ZV76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIT family. Yeast FIT2A/YFT2 subfamily.|||Endoplasmic reticulum membrane|||Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization). Involved in phospholipid biosynthesis.|||Membrane http://togogenome.org/gene/4950:TDEL_0B06140 ^@ http://purl.uniprot.org/uniprot/G8ZQ49 ^@ Similarity ^@ Belongs to the lysophospholipase family. http://togogenome.org/gene/4950:TDEL_0H02420 ^@ http://purl.uniprot.org/uniprot/G8ZZQ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0D03350 ^@ http://purl.uniprot.org/uniprot/G8ZTH5 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/4950:TDEL_0C01470 ^@ http://purl.uniprot.org/uniprot/G8ZR94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG8 family.|||Membrane|||autophagosome membrane http://togogenome.org/gene/4950:TDEL_0A06110 ^@ http://purl.uniprot.org/uniprot/G8ZMU9 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. METL family. http://togogenome.org/gene/4950:TDEL_0C04640 ^@ http://purl.uniprot.org/uniprot/G8ZS61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NST1 family.|||Cytoplasm|||May act as a negative regulator of salt tolerance. http://togogenome.org/gene/4950:TDEL_0F01210 ^@ http://purl.uniprot.org/uniprot/G8ZWD8 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/4950:TDEL_0C04450 ^@ http://purl.uniprot.org/uniprot/G8ZS42 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL13 family.|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. http://togogenome.org/gene/4950:TDEL_0G02320 ^@ http://purl.uniprot.org/uniprot/G8ZYX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86. http://togogenome.org/gene/4950:TDEL_0A04890 ^@ http://purl.uniprot.org/uniprot/G8ZMH7 ^@ Subcellular Location Annotation ^@ Vacuole http://togogenome.org/gene/4950:TDEL_0D03180 ^@ http://purl.uniprot.org/uniprot/G8ZTF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reverse transcriptase family. Telomerase subfamily.|||Nucleus|||Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.|||telomere http://togogenome.org/gene/4950:TDEL_0E00880 ^@ http://purl.uniprot.org/uniprot/G8ZUN7 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/4950:TDEL_0C01400 ^@ http://purl.uniprot.org/uniprot/G8ZR87 ^@ Similarity ^@ Belongs to the pyridoxine kinase family. http://togogenome.org/gene/4950:TDEL_0A06550 ^@ http://purl.uniprot.org/uniprot/G8ZMZ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiA prenyltransferase family.|||Converts protoheme IX and farnesyl diphosphate to heme O.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/4950:TDEL_0B05840 ^@ http://purl.uniprot.org/uniprot/G8ZQ19 ^@ Similarity ^@ Belongs to the WrbA family. http://togogenome.org/gene/4950:TDEL_0F01430 ^@ http://purl.uniprot.org/uniprot/G8ZWG0 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/4950:TDEL_0A02930 ^@ http://purl.uniprot.org/uniprot/G8ZLY1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0E01080 ^@ http://purl.uniprot.org/uniprot/G8ZUQ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0H01500 ^@ http://purl.uniprot.org/uniprot/G8ZZG5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase inhibitor family.|||Inhibits the enzyme activity of ATPase.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0B00850 ^@ http://purl.uniprot.org/uniprot/G8ZNM0 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. http://togogenome.org/gene/4950:TDEL_0B03310 ^@ http://purl.uniprot.org/uniprot/G8ZPB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E00640 ^@ http://purl.uniprot.org/uniprot/G8ZUL3 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx5 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/4950:TDEL_0E00920 ^@ http://purl.uniprot.org/uniprot/G8ZUP1 ^@ Function|||Similarity ^@ 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).|||Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/4950:TDEL_0E03710 ^@ http://purl.uniprot.org/uniprot/G8ZVH0 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/4950:TDEL_0D00840 ^@ http://purl.uniprot.org/uniprot/G8ZSS4 ^@ Function|||Similarity ^@ Belongs to the dihydroxyacetone kinase (DAK) family.|||Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde. http://togogenome.org/gene/4950:TDEL_0C04140 ^@ http://purl.uniprot.org/uniprot/G8ZS11 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/4950:TDEL_0E03610 ^@ http://purl.uniprot.org/uniprot/G8ZVG0 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/4950:TDEL_0C00350 ^@ http://purl.uniprot.org/uniprot/G8ZQY2 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. http://togogenome.org/gene/4950:TDEL_0B04610 ^@ http://purl.uniprot.org/uniprot/G8ZPP6 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/4950:TDEL_0A03930 ^@ http://purl.uniprot.org/uniprot/G8ZM81 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.|||Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. http://togogenome.org/gene/4950:TDEL_0A05670 ^@ http://purl.uniprot.org/uniprot/G8ZMQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase T2 family.|||Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.|||Vacuole lumen http://togogenome.org/gene/4950:TDEL_0F05440 ^@ http://purl.uniprot.org/uniprot/G8ZXL1 ^@ Similarity ^@ Belongs to the eIF-2B gamma/epsilon subunits family. http://togogenome.org/gene/4950:TDEL_0B04500 ^@ http://purl.uniprot.org/uniprot/G8ZPN5 ^@ Similarity ^@ Belongs to the acetyl-CoA hydrolase/transferase family. http://togogenome.org/gene/4950:TDEL_0A05150 ^@ http://purl.uniprot.org/uniprot/G8ZMK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC62 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0D02140 ^@ http://purl.uniprot.org/uniprot/G8ZT54 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family. http://togogenome.org/gene/4950:TDEL_0H01760 ^@ http://purl.uniprot.org/uniprot/G8ZZJ1 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/4950:TDEL_0G02910 ^@ http://purl.uniprot.org/uniprot/G8ZXP1 ^@ Similarity ^@ Belongs to the proteasome subunit S9 family. http://togogenome.org/gene/4950:TDEL_0B03100 ^@ http://purl.uniprot.org/uniprot/G8ZP95 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/4950:TDEL_0B03780 ^@ http://purl.uniprot.org/uniprot/G8ZPG3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 72 family.|||Cell membrane|||Membrane|||Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. http://togogenome.org/gene/4950:TDEL_0B06000 ^@ http://purl.uniprot.org/uniprot/G8ZQ35 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.|||Homodimer. http://togogenome.org/gene/4950:TDEL_0B03850 ^@ http://purl.uniprot.org/uniprot/G8ZPH0 ^@ Similarity ^@ Belongs to the class-I DAHP synthase family. http://togogenome.org/gene/4950:TDEL_0F02720 ^@ http://purl.uniprot.org/uniprot/G8ZWT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat NOL10/ENP2 family.|||nucleolus http://togogenome.org/gene/4950:TDEL_0E01140 ^@ http://purl.uniprot.org/uniprot/G8ZUR3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIIc family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0E00740 ^@ http://purl.uniprot.org/uniprot/G8ZUM3 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/4950:TDEL_0C05490 ^@ http://purl.uniprot.org/uniprot/G8ZSE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL43 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0F00200 ^@ http://purl.uniprot.org/uniprot/G8ZW37 ^@ Similarity ^@ Belongs to the histidine acid phosphatase family. http://togogenome.org/gene/4950:TDEL_0A05710 ^@ http://purl.uniprot.org/uniprot/G8ZMQ9 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/4950:TDEL_0A05420 ^@ http://purl.uniprot.org/uniprot/G8ZMN0 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/4950:TDEL_0B01900 ^@ http://purl.uniprot.org/uniprot/G8ZNX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A02120 ^@ http://purl.uniprot.org/uniprot/G8ZLQ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 11 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B02590 ^@ http://purl.uniprot.org/uniprot/G8ZP44 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/4950:TDEL_0F03840 ^@ http://purl.uniprot.org/uniprot/G8ZX51 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/4950:TDEL_0A01490 ^@ http://purl.uniprot.org/uniprot/G8ZLI7 ^@ Similarity|||Subunit ^@ Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.|||Homotetramer. http://togogenome.org/gene/4950:TDEL_0E04860 ^@ http://purl.uniprot.org/uniprot/G8ZVT5 ^@ Domain|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DENR family.|||Cytoplasm|||Interacts with the 40S ribosomal subunit.|||The SUI1 domain may be involved in RNA binding. http://togogenome.org/gene/4950:TDEL_0G04000 ^@ http://purl.uniprot.org/uniprot/G8ZY00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/4950:TDEL_0B01310 ^@ http://purl.uniprot.org/uniprot/G8ZNR6 ^@ Similarity ^@ Belongs to the TTC4 family. http://togogenome.org/gene/4950:TDEL_0A07980 ^@ http://purl.uniprot.org/uniprot/G8ZND6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0C02910 ^@ http://purl.uniprot.org/uniprot/G8ZRN8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CND2 (condensin subunit 2) family.|||Chromosome|||Cytoplasm|||Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. http://togogenome.org/gene/4950:TDEL_0G04540 ^@ http://purl.uniprot.org/uniprot/G8ZY54 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/4950:TDEL_0D04940 ^@ http://purl.uniprot.org/uniprot/G8ZTY4 ^@ Similarity ^@ Belongs to the BRX1 family. http://togogenome.org/gene/4950:TDEL_0A00690 ^@ http://purl.uniprot.org/uniprot/G8ZLA7 ^@ Similarity ^@ Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. http://togogenome.org/gene/4950:TDEL_0B01850 ^@ http://purl.uniprot.org/uniprot/G8ZNX0 ^@ Similarity ^@ Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family. http://togogenome.org/gene/4950:TDEL_0G02480 ^@ http://purl.uniprot.org/uniprot/G8ZYZ0 ^@ Cofactor|||Similarity ^@ Belongs to the chorismate synthase family.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/4950:TDEL_0A03370 ^@ http://purl.uniprot.org/uniprot/G8ZM25 ^@ Similarity|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Octamer of two non-identical subunits IDH1 and IDH2. http://togogenome.org/gene/4950:TDEL_0B03010 ^@ http://purl.uniprot.org/uniprot/G8ZP86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGC family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A01000 ^@ http://purl.uniprot.org/uniprot/G8ZLD8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0H01880 ^@ http://purl.uniprot.org/uniprot/G8ZZK3 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/4950:TDEL_0G03170 ^@ http://purl.uniprot.org/uniprot/G8ZXR7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/4950:TDEL_0D01150 ^@ http://purl.uniprot.org/uniprot/G8ZSV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Cell membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0F02750 ^@ http://purl.uniprot.org/uniprot/G8ZWU2 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/4950:TDEL_0C02050 ^@ http://purl.uniprot.org/uniprot/G8ZRF2 ^@ Similarity ^@ Belongs to the epsin family. http://togogenome.org/gene/4950:TDEL_0E01790 ^@ http://purl.uniprot.org/uniprot/G8ZUX8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D05070 ^@ http://purl.uniprot.org/uniprot/G8ZTZ7 ^@ Similarity ^@ Belongs to the TAF9 family. CENP-S/MHF1 subfamily. http://togogenome.org/gene/4950:TDEL_0E00310 ^@ http://purl.uniprot.org/uniprot/G8ZUI0 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/4950:TDEL_0B00730 ^@ http://purl.uniprot.org/uniprot/G8ZNK8 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/4950:TDEL_0D05710 ^@ http://purl.uniprot.org/uniprot/G8ZU61 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0C04320 ^@ http://purl.uniprot.org/uniprot/G8ZS29 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/4950:TDEL_0G02100 ^@ http://purl.uniprot.org/uniprot/G8ZYV2 ^@ Similarity ^@ Belongs to the LST4 family. http://togogenome.org/gene/4950:TDEL_0G04510 ^@ http://purl.uniprot.org/uniprot/G8ZY51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0F03640 ^@ http://purl.uniprot.org/uniprot/G8ZX31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||cytoskeleton http://togogenome.org/gene/4950:TDEL_0E03990 ^@ http://purl.uniprot.org/uniprot/G8ZVJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTF2H2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B04250 ^@ http://purl.uniprot.org/uniprot/G8ZPL0 ^@ Similarity ^@ Belongs to the DDI1 family. http://togogenome.org/gene/4950:TDEL_0B01670 ^@ http://purl.uniprot.org/uniprot/G8ZNV2 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/4950:TDEL_0G03020 ^@ http://purl.uniprot.org/uniprot/G8ZXQ2 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/4950:TDEL_0H00270 ^@ http://purl.uniprot.org/uniprot/G8ZZ42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G01110 ^@ http://purl.uniprot.org/uniprot/G8ZYK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDA11 family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0F05200 ^@ http://purl.uniprot.org/uniprot/G8ZXI7 ^@ Similarity ^@ Belongs to the sirtuin family. Class I subfamily. http://togogenome.org/gene/4950:TDEL_0D06310 ^@ http://purl.uniprot.org/uniprot/G8ZUC1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NadC/ModD family.|||Hexamer formed by 3 homodimers.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/4950:TDEL_0B00180 ^@ http://purl.uniprot.org/uniprot/G8ZNF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ku70 family.|||Nucleus|||telomere http://togogenome.org/gene/4950:TDEL_0G03220 ^@ http://purl.uniprot.org/uniprot/G8ZXS2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/4950:TDEL_0A05460 ^@ http://purl.uniprot.org/uniprot/G8ZMN4 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/4950:TDEL_0D01050 ^@ http://purl.uniprot.org/uniprot/G8ZSU5 ^@ Similarity|||Subunit ^@ Belongs to the PPP phosphatase family. PP-2B subfamily.|||Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. http://togogenome.org/gene/4950:TDEL_0E01340 ^@ http://purl.uniprot.org/uniprot/G8ZUT3 ^@ Similarity ^@ Belongs to the CCDC22 family. http://togogenome.org/gene/4950:TDEL_0G02600 ^@ http://purl.uniprot.org/uniprot/G8ZZ02 ^@ Similarity ^@ Belongs to the putative lipase ROG1 family. http://togogenome.org/gene/4950:TDEL_0E02240 ^@ http://purl.uniprot.org/uniprot/G8ZV23 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/4950:TDEL_0B03440 ^@ http://purl.uniprot.org/uniprot/G8ZPC9 ^@ Similarity ^@ Belongs to the RNase H family. http://togogenome.org/gene/4950:TDEL_0G01930 ^@ http://purl.uniprot.org/uniprot/G8ZYT5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GON7 family.|||Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.|||Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D03560 ^@ http://purl.uniprot.org/uniprot/G8ZTJ6 ^@ Similarity ^@ Belongs to the fl(2)d family. http://togogenome.org/gene/4950:TDEL_0B01130 ^@ http://purl.uniprot.org/uniprot/G8ZNP8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0E05510 ^@ http://purl.uniprot.org/uniprot/G8ZW00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.|||Belongs to the peptidase S16 family.|||Peroxisome matrix http://togogenome.org/gene/4950:TDEL_0H00180 ^@ http://purl.uniprot.org/uniprot/G8ZZ33 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0F05150 ^@ http://purl.uniprot.org/uniprot/G8ZXI2 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/4950:TDEL_0E01420 ^@ http://purl.uniprot.org/uniprot/G8ZUU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A02160 ^@ http://purl.uniprot.org/uniprot/G8ZLQ4 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/4950:TDEL_0C01650 ^@ http://purl.uniprot.org/uniprot/G8ZRB2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion inner membrane|||Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration. http://togogenome.org/gene/4950:TDEL_0A07300 ^@ http://purl.uniprot.org/uniprot/G8ZN68 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family. http://togogenome.org/gene/4950:TDEL_0F02180 ^@ http://purl.uniprot.org/uniprot/G8ZWN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.|||Cytoplasm|||S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha at 'Lys-79'. http://togogenome.org/gene/4950:TDEL_0E02710 ^@ http://purl.uniprot.org/uniprot/G8ZV70 ^@ Similarity ^@ Belongs to the asparaginase 1 family. http://togogenome.org/gene/4950:TDEL_0D02090 ^@ http://purl.uniprot.org/uniprot/G8ZT49 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/4950:TDEL_0D02900 ^@ http://purl.uniprot.org/uniprot/G8ZTD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0B00650 ^@ http://purl.uniprot.org/uniprot/G8ZNK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase U48 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0A08010 ^@ http://purl.uniprot.org/uniprot/G8ZND9 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0G01830 ^@ http://purl.uniprot.org/uniprot/G8ZYS5 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Component of the ribosome. http://togogenome.org/gene/4950:TDEL_0A00280 ^@ http://purl.uniprot.org/uniprot/G8ZL66 ^@ Subcellular Location Annotation ^@ Peroxisome membrane|||cytosol http://togogenome.org/gene/4950:TDEL_0G00420 ^@ http://purl.uniprot.org/uniprot/G8ZYD4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YME2 family.|||Membrane|||Mitochondrion inner membrane|||Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA. http://togogenome.org/gene/4950:TDEL_0B00820 ^@ http://purl.uniprot.org/uniprot/G8ZNL7 ^@ Similarity ^@ Belongs to the SAP30 family. http://togogenome.org/gene/4950:TDEL_0B04990 ^@ http://purl.uniprot.org/uniprot/G8ZPT4 ^@ Similarity ^@ Belongs to the Tom22 family. http://togogenome.org/gene/4950:TDEL_0B02040 ^@ http://purl.uniprot.org/uniprot/G8ZNY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVF1 family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0G01330 ^@ http://purl.uniprot.org/uniprot/G8ZYM5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/4950:TDEL_0D06180 ^@ http://purl.uniprot.org/uniprot/G8ZUA8 ^@ Function|||Similarity ^@ Belongs to the IRC6 family.|||Involved in gross chromosomal rearrangements (GCRs) and telomere healing. http://togogenome.org/gene/4950:TDEL_0D05970 ^@ http://purl.uniprot.org/uniprot/G8ZU87 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MDM34 family.|||Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and TDEL0D05970.|||Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. TDEL0D05970 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.|||Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.|||Mitochondrion outer membrane http://togogenome.org/gene/4950:TDEL_0B06410 ^@ http://purl.uniprot.org/uniprot/G8ZQ76 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/4950:TDEL_0A00460 ^@ http://purl.uniprot.org/uniprot/G8ZL84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 7 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E02350 ^@ http://purl.uniprot.org/uniprot/G8ZV34 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/4950:TDEL_0H02040 ^@ http://purl.uniprot.org/uniprot/G8ZZL9 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/4950:TDEL_0C07020 ^@ http://purl.uniprot.org/uniprot/G8ZQV4 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) per subunit. http://togogenome.org/gene/4950:TDEL_0F02300 ^@ http://purl.uniprot.org/uniprot/G8ZWP7 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0G00260 ^@ http://purl.uniprot.org/uniprot/G8ZYB8 ^@ Similarity ^@ Belongs to the ELP6 family. http://togogenome.org/gene/4950:TDEL_0D05430 ^@ http://purl.uniprot.org/uniprot/G8ZU33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0C02810 ^@ http://purl.uniprot.org/uniprot/G8ZRM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SHO1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0H03920 ^@ http://purl.uniprot.org/uniprot/G9A057 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family. http://togogenome.org/gene/4950:TDEL_0H02580 ^@ http://purl.uniprot.org/uniprot/G8ZZS3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL29 family. http://togogenome.org/gene/4950:TDEL_0F01800 ^@ http://purl.uniprot.org/uniprot/G8ZWJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM NCBP2 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G00870 ^@ http://purl.uniprot.org/uniprot/G8ZYH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||microtubule organizing center http://togogenome.org/gene/4950:TDEL_0D00470 ^@ http://purl.uniprot.org/uniprot/G8ZSN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM18/AIM46 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0E02460 ^@ http://purl.uniprot.org/uniprot/G8ZV45 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPI1/TEX10 family.|||Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.|||Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A03570 ^@ http://purl.uniprot.org/uniprot/G8ZM45 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/4950:TDEL_0H03750 ^@ http://purl.uniprot.org/uniprot/G9A040 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/4950:TDEL_0D04060 ^@ http://purl.uniprot.org/uniprot/G8ZTP6 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/4950:TDEL_0B06310 ^@ http://purl.uniprot.org/uniprot/G8ZQ66 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 3 family.|||Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. http://togogenome.org/gene/4950:TDEL_0F00320 ^@ http://purl.uniprot.org/uniprot/G8ZW49 ^@ Similarity ^@ Belongs to the MOG1 family. http://togogenome.org/gene/4950:TDEL_0H04050 ^@ http://purl.uniprot.org/uniprot/G9A070 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-Y family.|||Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C00830 ^@ http://purl.uniprot.org/uniprot/G8ZR30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D01980 ^@ http://purl.uniprot.org/uniprot/G8ZT38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the proteasome subunit S5B/HSM3 family.|||Cytoplasm|||Involved in DNA mismatch repair in slow-growing cells. Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC). http://togogenome.org/gene/4950:TDEL_0G00390 ^@ http://purl.uniprot.org/uniprot/G8ZYD1 ^@ Similarity ^@ Belongs to the CWC22 family. http://togogenome.org/gene/4950:TDEL_0C02060 ^@ http://purl.uniprot.org/uniprot/G8ZRF3 ^@ Similarity ^@ Belongs to the CENP-X/MHF2 family. http://togogenome.org/gene/4950:TDEL_0C03780 ^@ http://purl.uniprot.org/uniprot/G8ZRX5 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/4950:TDEL_0C03520 ^@ http://purl.uniprot.org/uniprot/G8ZRU9 ^@ Subcellular Location Annotation ^@ Nucleus|||kinetochore http://togogenome.org/gene/4950:TDEL_0D03340 ^@ http://purl.uniprot.org/uniprot/G8ZTH4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0H02750 ^@ http://purl.uniprot.org/uniprot/G8ZZU0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/4950:TDEL_0F02800 ^@ http://purl.uniprot.org/uniprot/G8ZWU7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ALAD family.|||Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.|||Homooctamer. http://togogenome.org/gene/4950:TDEL_0A05140 ^@ http://purl.uniprot.org/uniprot/G8ZMK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/4950:TDEL_0H03930 ^@ http://purl.uniprot.org/uniprot/G9A058 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm|||Mitochondrion|||Monomer. http://togogenome.org/gene/4950:TDEL_0F00560 ^@ http://purl.uniprot.org/uniprot/G8ZW73 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/4950:TDEL_0E03870 ^@ http://purl.uniprot.org/uniprot/G8ZVI6 ^@ Function|||Similarity ^@ Belongs to the heat shock protein 70 family.|||Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis. http://togogenome.org/gene/4950:TDEL_0C03000 ^@ http://purl.uniprot.org/uniprot/G8ZRP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||Golgi apparatus membrane|||Membrane|||Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex. http://togogenome.org/gene/4950:TDEL_0A02130 ^@ http://purl.uniprot.org/uniprot/G8ZLQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SHE2 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G04760 ^@ http://purl.uniprot.org/uniprot/G8ZY76 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 32 family. http://togogenome.org/gene/4950:TDEL_0C06390 ^@ http://purl.uniprot.org/uniprot/G8ZQP1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0B06400 ^@ http://purl.uniprot.org/uniprot/G8ZQ75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LU7TM family.|||Membrane http://togogenome.org/gene/4950:TDEL_0B06010 ^@ http://purl.uniprot.org/uniprot/G8ZQ36 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/4950:TDEL_0A01010 ^@ http://purl.uniprot.org/uniprot/G8ZLD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DTD family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0G00650 ^@ http://purl.uniprot.org/uniprot/G8ZYF7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.|||Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/4950:TDEL_0A05570 ^@ http://purl.uniprot.org/uniprot/G8ZMP5|||http://purl.uniprot.org/uniprot/Q6XD66 ^@ Similarity ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family. http://togogenome.org/gene/4950:TDEL_0C00920 ^@ http://purl.uniprot.org/uniprot/G8ZR39 ^@ Similarity ^@ Belongs to the DAMOX/DASOX family. http://togogenome.org/gene/4950:TDEL_0G01970 ^@ http://purl.uniprot.org/uniprot/G8ZYT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP12 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0E03220 ^@ http://purl.uniprot.org/uniprot/G8ZVC1 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0C00990 ^@ http://purl.uniprot.org/uniprot/G8ZR46 ^@ Subcellular Location Annotation ^@ Membrane|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0G01340 ^@ http://purl.uniprot.org/uniprot/G8ZYM6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/4950:TDEL_0G04780 ^@ http://purl.uniprot.org/uniprot/G8ZY78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0E00690 ^@ http://purl.uniprot.org/uniprot/G8ZUL8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/4950:TDEL_0H03890 ^@ http://purl.uniprot.org/uniprot/G9A054 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0H03010 ^@ http://purl.uniprot.org/uniprot/G8ZZW6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0H00630 ^@ http://purl.uniprot.org/uniprot/G8ZZ78 ^@ Similarity ^@ Belongs to the GcvT family. CAF17 subfamily. http://togogenome.org/gene/4950:TDEL_0F04540 ^@ http://purl.uniprot.org/uniprot/G8ZXC1 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0E05410 ^@ http://purl.uniprot.org/uniprot/G8ZVZ0 ^@ Similarity ^@ Belongs to the CBP3 family. http://togogenome.org/gene/4950:TDEL_0B06100 ^@ http://purl.uniprot.org/uniprot/G8ZQ45 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/4950:TDEL_0B07010 ^@ http://purl.uniprot.org/uniprot/G8ZQD6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0B04070 ^@ http://purl.uniprot.org/uniprot/G8ZPJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.|||In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.|||Nucleus|||Responsible for methylating the 5'-cap structure of mRNAs. http://togogenome.org/gene/4950:TDEL_0A06840 ^@ http://purl.uniprot.org/uniprot/G8ZN22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP68 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.|||Cytoplasm|||nucleolus http://togogenome.org/gene/4950:TDEL_0G01650 ^@ http://purl.uniprot.org/uniprot/G8ZYQ7 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/4950:TDEL_0G01450 ^@ http://purl.uniprot.org/uniprot/G8ZYN7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adaptor protein complex 3 (AP-3) is a heterotetramer.|||Belongs to the adaptor complexes large subunit family.|||Golgi apparatus|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. http://togogenome.org/gene/4950:TDEL_0F03460 ^@ http://purl.uniprot.org/uniprot/G8ZX13 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0A01710 ^@ http://purl.uniprot.org/uniprot/G8ZLK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oligopeptide OPT transporter family.|||Membrane http://togogenome.org/gene/4950:TDEL_0B01230 ^@ http://purl.uniprot.org/uniprot/G8ZNQ8 ^@ Similarity ^@ Belongs to the PGA52 family. http://togogenome.org/gene/4950:TDEL_0D03700 ^@ http://purl.uniprot.org/uniprot/G8ZTL0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/4950:TDEL_0G02180 ^@ http://purl.uniprot.org/uniprot/G8ZYW0 ^@ Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. http://togogenome.org/gene/4950:TDEL_0A04910 ^@ http://purl.uniprot.org/uniprot/G8ZMH9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.|||Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B01040 ^@ http://purl.uniprot.org/uniprot/G8ZNN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal/bacterial/fungal opsin family.|||Membrane http://togogenome.org/gene/4950:TDEL_0F05480 ^@ http://purl.uniprot.org/uniprot/G8ZXL5 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/4950:TDEL_0A06560 ^@ http://purl.uniprot.org/uniprot/G8ZMZ4 ^@ Function|||Similarity ^@ Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.|||Belongs to the peptidase M67A family. http://togogenome.org/gene/4950:TDEL_0D03790 ^@ http://purl.uniprot.org/uniprot/G8ZTL9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvT family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/4950:TDEL_0H03560 ^@ http://purl.uniprot.org/uniprot/G9A021 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0A01290 ^@ http://purl.uniprot.org/uniprot/G8ZLG7 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||Component of the post-replicative DNA mismatch repair system (MMR). http://togogenome.org/gene/4950:TDEL_0G01020 ^@ http://purl.uniprot.org/uniprot/G8ZYJ4 ^@ Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily. http://togogenome.org/gene/4950:TDEL_0C03390 ^@ http://purl.uniprot.org/uniprot/G8ZRT6 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/4950:TDEL_0D05880 ^@ http://purl.uniprot.org/uniprot/G8ZU78 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CHZ1 family.|||Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.|||Nucleus http://togogenome.org/gene/4950:TDEL_0F00400 ^@ http://purl.uniprot.org/uniprot/G8ZW57 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the deoxyhypusine hydroxylase family.|||Binds 2 Fe(2+) ions per subunit.|||Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0G03200 ^@ http://purl.uniprot.org/uniprot/G8ZXS0 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/4950:TDEL_0F03650 ^@ http://purl.uniprot.org/uniprot/G8ZX32 ^@ Similarity ^@ Belongs to the RRP15 family. http://togogenome.org/gene/4950:TDEL_0A07400 ^@ http://purl.uniprot.org/uniprot/G8ZN78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PWP2 family.|||nucleolus http://togogenome.org/gene/4950:TDEL_0A02530 ^@ http://purl.uniprot.org/uniprot/G8ZLU1 ^@ Function ^@ Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins). http://togogenome.org/gene/4950:TDEL_0D01100 ^@ http://purl.uniprot.org/uniprot/G8ZSV0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/4950:TDEL_0A06480 ^@ http://purl.uniprot.org/uniprot/G8ZMY6 ^@ Function ^@ Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. http://togogenome.org/gene/4950:TDEL_0A03360 ^@ http://purl.uniprot.org/uniprot/G8ZM24 ^@ Similarity|||Subunit ^@ Belongs to the ubiquitin-activating E1 family.|||Heterodimer. http://togogenome.org/gene/4950:TDEL_0C02490 ^@ http://purl.uniprot.org/uniprot/G8ZRJ6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.|||Binds 1 FAD per monomer.|||Irreversibly catalyzes the reduction of fumarate to succinate. http://togogenome.org/gene/4950:TDEL_0B05760 ^@ http://purl.uniprot.org/uniprot/G8ZQ11 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0A04980 ^@ http://purl.uniprot.org/uniprot/G8ZMI6 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/4950:TDEL_0B05080 ^@ http://purl.uniprot.org/uniprot/G8ZPU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAF1 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0H03440 ^@ http://purl.uniprot.org/uniprot/G9A009 ^@ Similarity ^@ Belongs to the FUN14 family. http://togogenome.org/gene/4950:TDEL_0A04950 ^@ http://purl.uniprot.org/uniprot/G8ZMI3 ^@ Similarity ^@ Belongs to the ZNF598/HEL2 family. http://togogenome.org/gene/4950:TDEL_0D00440 ^@ http://purl.uniprot.org/uniprot/G8ZSN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IML1 family.|||Membrane|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0C06340 ^@ http://purl.uniprot.org/uniprot/G8ZQN6 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. MetX family. http://togogenome.org/gene/4950:TDEL_0B06200 ^@ http://purl.uniprot.org/uniprot/G8ZQ55 ^@ Function|||Similarity ^@ Belongs to the diphthine synthase family.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/4950:TDEL_0D01870 ^@ http://purl.uniprot.org/uniprot/G8ZT27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL54 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0B01550 ^@ http://purl.uniprot.org/uniprot/G8ZNU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.|||Belongs to the TRM44 family.|||Cytoplasm|||Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase. http://togogenome.org/gene/4950:TDEL_0E01670 ^@ http://purl.uniprot.org/uniprot/G8ZUW6 ^@ Similarity ^@ In the N-terminal section; belongs to the FGAMS family. http://togogenome.org/gene/4950:TDEL_0D03570 ^@ http://purl.uniprot.org/uniprot/G8ZTJ7 ^@ Similarity ^@ Belongs to the class-I DAHP synthase family. http://togogenome.org/gene/4950:TDEL_0A03770 ^@ http://purl.uniprot.org/uniprot/G8ZM65 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.|||Membrane http://togogenome.org/gene/4950:TDEL_0F01600 ^@ http://purl.uniprot.org/uniprot/G8ZWH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NASP family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G00620 ^@ http://purl.uniprot.org/uniprot/G8ZYF4 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I family. http://togogenome.org/gene/4950:TDEL_0G00890 ^@ http://purl.uniprot.org/uniprot/G8ZYI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. GCN5 subfamily.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D01340 ^@ http://purl.uniprot.org/uniprot/G8ZSX4 ^@ Similarity ^@ Belongs to the glutamate--cysteine ligase type 3 family. http://togogenome.org/gene/4950:TDEL_0A01670 ^@ http://purl.uniprot.org/uniprot/G8ZLK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF6 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C01760 ^@ http://purl.uniprot.org/uniprot/G8ZRC3 ^@ Similarity ^@ Belongs to the MYST (SAS/MOZ) family. http://togogenome.org/gene/4950:TDEL_0C05330 ^@ http://purl.uniprot.org/uniprot/G8ZSD0 ^@ Similarity ^@ Belongs to the CCZ1 family. http://togogenome.org/gene/4950:TDEL_0H03340 ^@ http://purl.uniprot.org/uniprot/G8ZZZ9 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0C02240 ^@ http://purl.uniprot.org/uniprot/G8ZRH1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. http://togogenome.org/gene/4950:TDEL_0G04850 ^@ http://purl.uniprot.org/uniprot/G8ZY85 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/4950:TDEL_0G03920 ^@ http://purl.uniprot.org/uniprot/G8ZXZ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.|||Cytoplasm|||S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'. http://togogenome.org/gene/4950:TDEL_0C03870 ^@ http://purl.uniprot.org/uniprot/G8ZRY4 ^@ Function|||Similarity ^@ Belongs to the beta-class carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/4950:TDEL_0B00640 ^@ http://purl.uniprot.org/uniprot/G8ZNJ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0A01040 ^@ http://purl.uniprot.org/uniprot/G8ZLE2 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/4950:TDEL_0G00690 ^@ http://purl.uniprot.org/uniprot/G8ZYG1 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/4950:TDEL_0D02310 ^@ http://purl.uniprot.org/uniprot/G8ZT71 ^@ Similarity ^@ Belongs to the peptidase M28 family. http://togogenome.org/gene/4950:TDEL_0A07950 ^@ http://purl.uniprot.org/uniprot/G8ZND3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.|||GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.|||nucleolus http://togogenome.org/gene/4950:TDEL_0C04510 ^@ http://purl.uniprot.org/uniprot/G8ZS48 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRT14 family.|||Involved in ribosome biogenesis, probably through modulation of rDNA transcription.|||nucleolus http://togogenome.org/gene/4950:TDEL_0C01790 ^@ http://purl.uniprot.org/uniprot/G8ZRC6 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/4950:TDEL_0C00410 ^@ http://purl.uniprot.org/uniprot/G8ZQY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0G02410 ^@ http://purl.uniprot.org/uniprot/G8ZYY3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 38 family. http://togogenome.org/gene/4950:TDEL_0B00970 ^@ http://purl.uniprot.org/uniprot/G8ZNN2 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic AdoMetDC family.|||Binds 1 pyruvoyl group covalently per subunit. http://togogenome.org/gene/4950:TDEL_0B06790 ^@ http://purl.uniprot.org/uniprot/G8ZQB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEF1 family.|||Cytoplasm|||Nucleus|||telomere http://togogenome.org/gene/4950:TDEL_0A08050 ^@ http://purl.uniprot.org/uniprot/G8ZNE3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0A02070 ^@ http://purl.uniprot.org/uniprot/G8ZLP5 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. http://togogenome.org/gene/4950:TDEL_0C05950 ^@ http://purl.uniprot.org/uniprot/G8ZSJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RTC4 family.|||May be involved in a process influencing telomere capping.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E01020 ^@ http://purl.uniprot.org/uniprot/G8ZUQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BRE1 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0H04390 ^@ http://purl.uniprot.org/uniprot/G9A0A4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the rad1 family.|||Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D01040 ^@ http://purl.uniprot.org/uniprot/G8ZSU4 ^@ Similarity ^@ Belongs to the TSR2 family. http://togogenome.org/gene/4950:TDEL_0B03700 ^@ http://purl.uniprot.org/uniprot/G8ZPF5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0C02040 ^@ http://purl.uniprot.org/uniprot/G8ZRF1 ^@ Similarity ^@ Belongs to the ATP-dependent DNA ligase family. http://togogenome.org/gene/4950:TDEL_0D03550 ^@ http://purl.uniprot.org/uniprot/G8ZTJ5 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/4950:TDEL_0A01850 ^@ http://purl.uniprot.org/uniprot/G8ZLM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B01510 ^@ http://purl.uniprot.org/uniprot/G8ZNT6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAC-beta family.|||Cytoplasm|||Nucleus|||Part of the nascent polypeptide-associated complex (NAC). http://togogenome.org/gene/4950:TDEL_0B04940 ^@ http://purl.uniprot.org/uniprot/G8ZPS9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EAF7 family.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D01550 ^@ http://purl.uniprot.org/uniprot/G8ZSZ5 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/4950:TDEL_0A00390 ^@ http://purl.uniprot.org/uniprot/G8ZL77 ^@ Function|||Similarity ^@ Belongs to the eukaryotic initiation factor 4E family.|||Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. http://togogenome.org/gene/4950:TDEL_0B05120 ^@ http://purl.uniprot.org/uniprot/G8ZPU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1C family.|||Nuclear serine protease which mediates apoptosis.|||Nucleus http://togogenome.org/gene/4950:TDEL_0F02120 ^@ http://purl.uniprot.org/uniprot/G8ZWM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OS-9 family.|||Endoplasmic reticulum membrane|||Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation. http://togogenome.org/gene/4950:TDEL_0B04180 ^@ http://purl.uniprot.org/uniprot/G8ZPK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. http://togogenome.org/gene/4950:TDEL_0G04740 ^@ http://purl.uniprot.org/uniprot/G8ZY74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0C06240 ^@ http://purl.uniprot.org/uniprot/G8ZQM6 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/4950:TDEL_0F01450 ^@ http://purl.uniprot.org/uniprot/G8ZWG2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0A07420 ^@ http://purl.uniprot.org/uniprot/G8ZN80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IMPACT family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0G04480 ^@ http://purl.uniprot.org/uniprot/G8ZY48 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/4950:TDEL_0C04820 ^@ http://purl.uniprot.org/uniprot/G8ZS79 ^@ Function|||Similarity ^@ Belongs to the SEC8 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/4950:TDEL_0B01090 ^@ http://purl.uniprot.org/uniprot/G8ZNP4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL20 family. http://togogenome.org/gene/4950:TDEL_0G02070 ^@ http://purl.uniprot.org/uniprot/G8ZYU9 ^@ Similarity ^@ Belongs to the PGA52 family. http://togogenome.org/gene/4950:TDEL_0F03920 ^@ http://purl.uniprot.org/uniprot/G8ZX59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the securin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0D01830 ^@ http://purl.uniprot.org/uniprot/G8ZT23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COA3 family.|||Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.|||Membrane|||Required for assembly of cytochrome c oxidase (complex IV). http://togogenome.org/gene/4950:TDEL_0E04430 ^@ http://purl.uniprot.org/uniprot/G8ZVP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CBP4 family.|||Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0A02990 ^@ http://purl.uniprot.org/uniprot/G8ZLY7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0E02580 ^@ http://purl.uniprot.org/uniprot/G8ZV57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YSP2 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A02820 ^@ http://purl.uniprot.org/uniprot/G8ZLX0 ^@ Function|||Similarity ^@ Belongs to the BYE1 family.|||Negative regulator of transcription elongation. http://togogenome.org/gene/4950:TDEL_0G04370 ^@ http://purl.uniprot.org/uniprot/G8ZY37 ^@ Function|||Similarity ^@ Belongs to the type IB topoisomerase family.|||Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/4950:TDEL_0G02450 ^@ http://purl.uniprot.org/uniprot/G8ZYY7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-14 family.|||Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.|||Peroxisome membrane http://togogenome.org/gene/4950:TDEL_0C00600 ^@ http://purl.uniprot.org/uniprot/G8ZR07 ^@ Similarity ^@ Belongs to the oligoribonuclease family. http://togogenome.org/gene/4950:TDEL_0A05960 ^@ http://purl.uniprot.org/uniprot/G8ZMT4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0G02650 ^@ http://purl.uniprot.org/uniprot/G8ZZ07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0C02430 ^@ http://purl.uniprot.org/uniprot/G8ZRJ0 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/4950:TDEL_0C02710 ^@ http://purl.uniprot.org/uniprot/G8ZRL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0B04060 ^@ http://purl.uniprot.org/uniprot/G8ZPJ1 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/4950:TDEL_0A06010 ^@ http://purl.uniprot.org/uniprot/G8ZMT9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/4950:TDEL_0A07130 ^@ http://purl.uniprot.org/uniprot/G8ZN51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WHI5/NRM1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0G00310 ^@ http://purl.uniprot.org/uniprot/G8ZYC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 17 family.|||cell wall http://togogenome.org/gene/4950:TDEL_0F01470 ^@ http://purl.uniprot.org/uniprot/G8ZWG4 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/4950:TDEL_0H00470 ^@ http://purl.uniprot.org/uniprot/G8ZZ62 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 10 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D03250 ^@ http://purl.uniprot.org/uniprot/G8ZTG5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0F04810 ^@ http://purl.uniprot.org/uniprot/G8ZXE8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SEC5 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||Component of the exocyst complex. http://togogenome.org/gene/4950:TDEL_0F03160 ^@ http://purl.uniprot.org/uniprot/G8ZWY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase PH family.|||nucleolus http://togogenome.org/gene/4950:TDEL_0H03980 ^@ http://purl.uniprot.org/uniprot/G9A063 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mis12 family.|||kinetochore http://togogenome.org/gene/4950:TDEL_0A07380 ^@ http://purl.uniprot.org/uniprot/G8ZN76 ^@ Caution|||Similarity ^@ Belongs to the globin family.|||Belongs to the threonine synthase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/4950:TDEL_0E04390 ^@ http://purl.uniprot.org/uniprot/G8ZVN8 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/4950:TDEL_0E00250 ^@ http://purl.uniprot.org/uniprot/G8ZUH4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0A07610 ^@ http://purl.uniprot.org/uniprot/G8ZN99 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D03090 ^@ http://purl.uniprot.org/uniprot/G8ZTE9 ^@ Similarity ^@ Belongs to the PRP18 family. http://togogenome.org/gene/4950:TDEL_0F05630 ^@ http://purl.uniprot.org/uniprot/G8ZXN0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0F04230 ^@ http://purl.uniprot.org/uniprot/G8ZX90 ^@ Similarity ^@ Belongs to the REXO1/REXO3 family. http://togogenome.org/gene/4950:TDEL_0G03120 ^@ http://purl.uniprot.org/uniprot/G8ZXR2 ^@ Similarity ^@ Belongs to the NADH dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0B04350 ^@ http://purl.uniprot.org/uniprot/G8ZPM0 ^@ Similarity ^@ Belongs to the Rab GDI family. http://togogenome.org/gene/4950:TDEL_0F03170 ^@ http://purl.uniprot.org/uniprot/G8ZWY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0H01170 ^@ http://purl.uniprot.org/uniprot/G8ZZD2 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/4950:TDEL_0D01690 ^@ http://purl.uniprot.org/uniprot/G8ZT09 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/4950:TDEL_0D06230 ^@ http://purl.uniprot.org/uniprot/G8ZUB3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/4950:TDEL_0E00910 ^@ http://purl.uniprot.org/uniprot/G8ZUP0 ^@ Similarity ^@ Belongs to the SRR1 family. http://togogenome.org/gene/4950:TDEL_0F04550 ^@ http://purl.uniprot.org/uniprot/G8ZXC2 ^@ Similarity ^@ Belongs to the SLX4 family. http://togogenome.org/gene/4950:TDEL_0C05030 ^@ http://purl.uniprot.org/uniprot/G8ZSA0 ^@ Function ^@ Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER. http://togogenome.org/gene/4950:TDEL_0C00110 ^@ http://purl.uniprot.org/uniprot/G8ZQV8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0B01680 ^@ http://purl.uniprot.org/uniprot/G8ZNV3 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/4950:TDEL_0G03760 ^@ http://purl.uniprot.org/uniprot/G8ZXX6 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/4950:TDEL_0F05190 ^@ http://purl.uniprot.org/uniprot/G8ZXI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A03030 ^@ http://purl.uniprot.org/uniprot/G8ZLZ1 ^@ Function|||Similarity ^@ Belongs to the TFIIE alpha subunit family.|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. http://togogenome.org/gene/4950:TDEL_0C05240 ^@ http://purl.uniprot.org/uniprot/G8ZSC1 ^@ Similarity ^@ Belongs to the glycosyltransferase 20 family. http://togogenome.org/gene/4950:TDEL_0A02270 ^@ http://purl.uniprot.org/uniprot/G8ZLR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0D01630 ^@ http://purl.uniprot.org/uniprot/G8ZT03 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0E00130 ^@ http://purl.uniprot.org/uniprot/G8ZUG2 ^@ Cofactor|||Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.|||Binds 1 Fe cation per subunit.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/4950:TDEL_0H04480 ^@ http://purl.uniprot.org/uniprot/G9A0B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0G02060 ^@ http://purl.uniprot.org/uniprot/G8ZYU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 4 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0E05720 ^@ http://purl.uniprot.org/uniprot/G8ZW21 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0E04890 ^@ http://purl.uniprot.org/uniprot/G8ZVT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/4950:TDEL_0E02790 ^@ http://purl.uniprot.org/uniprot/G8ZV78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMP52 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/4950:TDEL_0C06180 ^@ http://purl.uniprot.org/uniprot/G8ZQM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A00580 ^@ http://purl.uniprot.org/uniprot/G8ZL96 ^@ Similarity ^@ Belongs to the KRI1 family. http://togogenome.org/gene/4950:TDEL_0D04270 ^@ http://purl.uniprot.org/uniprot/G8ZTR7 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/4950:TDEL_0F04660 ^@ http://purl.uniprot.org/uniprot/G8ZXD3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0E05600 ^@ http://purl.uniprot.org/uniprot/G8ZW09 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/4950:TDEL_0A01520 ^@ http://purl.uniprot.org/uniprot/G8ZLJ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex.|||In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E01400 ^@ http://purl.uniprot.org/uniprot/G8ZUT9 ^@ Function|||Similarity ^@ Belongs to the transferase hexapeptide repeat family.|||Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint. http://togogenome.org/gene/4950:TDEL_0D03800 ^@ http://purl.uniprot.org/uniprot/G8ZTM0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0G00340 ^@ http://purl.uniprot.org/uniprot/G8ZYC6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0D03680 ^@ http://purl.uniprot.org/uniprot/G8ZTK8 ^@ Similarity ^@ Belongs to the VPS54 family. http://togogenome.org/gene/4950:TDEL_0A01140 ^@ http://purl.uniprot.org/uniprot/G8ZLF2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat IPI3/WDR18 family.|||Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.|||Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G04140 ^@ http://purl.uniprot.org/uniprot/G8ZY14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.|||Endoplasmic reticulum membrane http://togogenome.org/gene/4950:TDEL_0H03730 ^@ http://purl.uniprot.org/uniprot/G9A038 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCR4/nocturin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0G04040 ^@ http://purl.uniprot.org/uniprot/G8ZY04 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferrochelatase family.|||Catalyzes the ferrous insertion into protoporphyrin IX.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0C06680 ^@ http://purl.uniprot.org/uniprot/G8ZQS0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG22 family.|||Membrane|||Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0B06320 ^@ http://purl.uniprot.org/uniprot/G8ZQ67 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/4950:TDEL_0F04910 ^@ http://purl.uniprot.org/uniprot/G8ZXF8 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/4950:TDEL_0D02880 ^@ http://purl.uniprot.org/uniprot/G8ZTC8 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/4950:TDEL_0H02120 ^@ http://purl.uniprot.org/uniprot/G8ZZM7 ^@ Function|||Similarity ^@ Belongs to the ATP phosphoribosyltransferase family.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of the enzymatic activity. http://togogenome.org/gene/4950:TDEL_0B07630 ^@ http://purl.uniprot.org/uniprot/G8ZQJ8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/4950:TDEL_0B02250 ^@ http://purl.uniprot.org/uniprot/G8ZP10 ^@ Similarity ^@ Belongs to the pantothenate synthetase family. http://togogenome.org/gene/4950:TDEL_0H03430 ^@ http://purl.uniprot.org/uniprot/G9A008 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D04440 ^@ http://purl.uniprot.org/uniprot/G8ZTT4 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/4950:TDEL_0F05090 ^@ http://purl.uniprot.org/uniprot/G8ZXH6 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/4950:TDEL_0D05270 ^@ http://purl.uniprot.org/uniprot/G8ZU17 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/4950:TDEL_0B00370 ^@ http://purl.uniprot.org/uniprot/G8ZNH2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0H04400 ^@ http://purl.uniprot.org/uniprot/G9A0A5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family. http://togogenome.org/gene/4950:TDEL_0C05230 ^@ http://purl.uniprot.org/uniprot/G8ZSC0 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/4950:TDEL_0F05010 ^@ http://purl.uniprot.org/uniprot/G8ZXG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CybS family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0H04150 ^@ http://purl.uniprot.org/uniprot/G9A080 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/4950:TDEL_0A07660 ^@ http://purl.uniprot.org/uniprot/G8ZNA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC2 family.|||Component of the Arp2/3 complex.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/4950:TDEL_0C01290 ^@ http://purl.uniprot.org/uniprot/G8ZR76 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/4950:TDEL_0A04760 ^@ http://purl.uniprot.org/uniprot/G8ZMG4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/4950:TDEL_0E03950 ^@ http://purl.uniprot.org/uniprot/G8ZVJ4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/4950:TDEL_0E01270 ^@ http://purl.uniprot.org/uniprot/G8ZUS6 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/4950:TDEL_0C05990 ^@ http://purl.uniprot.org/uniprot/G8ZSJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/4950:TDEL_0E02630 ^@ http://purl.uniprot.org/uniprot/G8ZV62 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0E00210 ^@ http://purl.uniprot.org/uniprot/G8ZUH0 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/4950:TDEL_0C03280 ^@ http://purl.uniprot.org/uniprot/G8ZRS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FIP1 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G01980 ^@ http://purl.uniprot.org/uniprot/G8ZYU0 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/4950:TDEL_0H00160 ^@ http://purl.uniprot.org/uniprot/G8ZZ31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0B04360 ^@ http://purl.uniprot.org/uniprot/G8ZPM1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A07160 ^@ http://purl.uniprot.org/uniprot/G8ZN54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/4950:TDEL_0F00820 ^@ http://purl.uniprot.org/uniprot/G8ZW99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CHS7 family.|||Chaperone required for the export of the chitin synthase CHS3 from the endoplasmic reticulum.|||Interacts with CHS3.|||Membrane http://togogenome.org/gene/4950:TDEL_0C05260 ^@ http://purl.uniprot.org/uniprot/G8ZSC3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex. http://togogenome.org/gene/4950:TDEL_0A06290 ^@ http://purl.uniprot.org/uniprot/G8ZMW7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/4950:TDEL_0G02940 ^@ http://purl.uniprot.org/uniprot/G8ZXP4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP14 family.|||Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0B04860 ^@ http://purl.uniprot.org/uniprot/G8ZPS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A02660 ^@ http://purl.uniprot.org/uniprot/G8ZLV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0E02570 ^@ http://purl.uniprot.org/uniprot/G8ZV56 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SKP1 family.|||Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.|||Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/4950:TDEL_0G00810 ^@ http://purl.uniprot.org/uniprot/G8ZYH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVP26 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0C04590 ^@ http://purl.uniprot.org/uniprot/G8ZS56 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D04550 ^@ http://purl.uniprot.org/uniprot/G8ZTU5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0C01200 ^@ http://purl.uniprot.org/uniprot/G8ZR67 ^@ Similarity ^@ Belongs to the LOC1 family. http://togogenome.org/gene/4950:TDEL_0C04870 ^@ http://purl.uniprot.org/uniprot/G8ZS84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB4 family.|||Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D00170 ^@ http://purl.uniprot.org/uniprot/G8ZSK7 ^@ Function|||Similarity ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. http://togogenome.org/gene/4950:TDEL_0B06830 ^@ http://purl.uniprot.org/uniprot/G8ZQB8 ^@ Similarity ^@ Belongs to the EIS1 family. http://togogenome.org/gene/4950:TDEL_0C03560 ^@ http://purl.uniprot.org/uniprot/G8ZRV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/4950:TDEL_0B00330 ^@ http://purl.uniprot.org/uniprot/G8ZNG8 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/4950:TDEL_0A01060 ^@ http://purl.uniprot.org/uniprot/G8ZLE4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM22 complex.|||Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0C05970 ^@ http://purl.uniprot.org/uniprot/G8ZSJ4 ^@ Function|||Similarity ^@ Catalyzes three sequential steps of tetrahydrofolate biosynthesis.|||In the C-terminal section; belongs to the DHPS family.|||In the N-terminal section; belongs to the DHNA family.|||In the central section; belongs to the HPPK family. http://togogenome.org/gene/4950:TDEL_0C03330 ^@ http://purl.uniprot.org/uniprot/G8ZRT0 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/4950:TDEL_0C00930 ^@ http://purl.uniprot.org/uniprot/G8ZR40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D06630 ^@ http://purl.uniprot.org/uniprot/G8ZUF3 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/4950:TDEL_0D06670 ^@ http://purl.uniprot.org/uniprot/G8ZUF7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/4950:TDEL_0B04190 ^@ http://purl.uniprot.org/uniprot/G8ZPK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A03330 ^@ http://purl.uniprot.org/uniprot/G8ZM21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0E02120 ^@ http://purl.uniprot.org/uniprot/G8ZV11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Bud neck http://togogenome.org/gene/4950:TDEL_0G03530 ^@ http://purl.uniprot.org/uniprot/G8ZXV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.|||Endoplasmic reticulum membrane|||Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.|||Membrane http://togogenome.org/gene/4950:TDEL_0A01980 ^@ http://purl.uniprot.org/uniprot/G8ZLN6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0G01470 ^@ http://purl.uniprot.org/uniprot/G8ZYN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0A01870 ^@ http://purl.uniprot.org/uniprot/G8ZLM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NCBP1 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B02620 ^@ http://purl.uniprot.org/uniprot/G8ZP47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLD7 family.|||spindle pole http://togogenome.org/gene/4950:TDEL_0C00960 ^@ http://purl.uniprot.org/uniprot/G8ZR43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D05480 ^@ http://purl.uniprot.org/uniprot/G8ZU38 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D02660 ^@ http://purl.uniprot.org/uniprot/G8ZTA6 ^@ Similarity ^@ Belongs to the DAMOX/DASOX family. http://togogenome.org/gene/4950:TDEL_0H03030 ^@ http://purl.uniprot.org/uniprot/G8ZZW8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DDOST 48 kDa subunit family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). http://togogenome.org/gene/4950:TDEL_0D06430 ^@ http://purl.uniprot.org/uniprot/G8ZUD3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/4950:TDEL_0E04690 ^@ http://purl.uniprot.org/uniprot/G8ZVR8 ^@ Subcellular Location Annotation ^@ Membrane|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0F04300 ^@ http://purl.uniprot.org/uniprot/G8ZX97 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0E05700 ^@ http://purl.uniprot.org/uniprot/G8ZW19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A04270 ^@ http://purl.uniprot.org/uniprot/G8ZMB5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/4950:TDEL_0D04640 ^@ http://purl.uniprot.org/uniprot/G8ZTV4 ^@ Function|||Similarity ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. http://togogenome.org/gene/4950:TDEL_0B04170 ^@ http://purl.uniprot.org/uniprot/G8ZPK2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0H01310 ^@ http://purl.uniprot.org/uniprot/G8ZZE6 ^@ Similarity ^@ Belongs to the ERT1/acuK family. http://togogenome.org/gene/4950:TDEL_0H00550 ^@ http://purl.uniprot.org/uniprot/G8ZZ70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC4 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C05060 ^@ http://purl.uniprot.org/uniprot/G8ZSA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 1 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/4950:TDEL_0F00850 ^@ http://purl.uniprot.org/uniprot/G8ZWA2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0H02250 ^@ http://purl.uniprot.org/uniprot/G8ZZP0 ^@ Similarity ^@ Belongs to the TPA1 family. http://togogenome.org/gene/4950:TDEL_0D05040 ^@ http://purl.uniprot.org/uniprot/G8ZTZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0G03610 ^@ http://purl.uniprot.org/uniprot/G8ZXW1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/4950:TDEL_0E01760 ^@ http://purl.uniprot.org/uniprot/G8ZUX5 ^@ Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/4950:TDEL_0H02010 ^@ http://purl.uniprot.org/uniprot/G8ZZL6 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/4950:TDEL_0A06210 ^@ http://purl.uniprot.org/uniprot/G8ZMV9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/4950:TDEL_0C02840 ^@ http://purl.uniprot.org/uniprot/G8ZRN1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0E01930 ^@ http://purl.uniprot.org/uniprot/G8ZUZ2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/4950:TDEL_0C00520 ^@ http://purl.uniprot.org/uniprot/G8ZQZ9 ^@ Function|||Similarity ^@ Belongs to the DNA glycosylase MPG family.|||Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. http://togogenome.org/gene/4950:TDEL_0B02760 ^@ http://purl.uniprot.org/uniprot/G8ZP61 ^@ Similarity ^@ Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family. http://togogenome.org/gene/4950:TDEL_0C04210 ^@ http://purl.uniprot.org/uniprot/G8ZS18 ^@ Similarity ^@ Belongs to the XPG/RAD2 endonuclease family. http://togogenome.org/gene/4950:TDEL_0A07310 ^@ http://purl.uniprot.org/uniprot/G8ZN69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0B06190 ^@ http://purl.uniprot.org/uniprot/G8ZQ54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Golgi apparatus http://togogenome.org/gene/4950:TDEL_0E05130 ^@ http://purl.uniprot.org/uniprot/G8ZVW2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uS2 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.|||Cytoplasm|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. http://togogenome.org/gene/4950:TDEL_0C00580 ^@ http://purl.uniprot.org/uniprot/G8ZR05 ^@ Similarity|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/4950:TDEL_0B01150 ^@ http://purl.uniprot.org/uniprot/G8ZNQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRG7 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0A00380 ^@ http://purl.uniprot.org/uniprot/G8ZL76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0E00810 ^@ http://purl.uniprot.org/uniprot/G8ZUN0 ^@ Similarity ^@ Belongs to the CNOT9 family. http://togogenome.org/gene/4950:TDEL_0H03090 ^@ http://purl.uniprot.org/uniprot/G8ZZX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP16 family.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/4950:TDEL_0H04490 ^@ http://purl.uniprot.org/uniprot/G9A0B4 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/4950:TDEL_0D05190 ^@ http://purl.uniprot.org/uniprot/G8ZU09 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0C00560 ^@ http://purl.uniprot.org/uniprot/G8ZR03 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/4950:TDEL_0B02920 ^@ http://purl.uniprot.org/uniprot/G8ZP77 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/4950:TDEL_0A06380 ^@ http://purl.uniprot.org/uniprot/G8ZMX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG29 family.|||Preautophagosomal structure http://togogenome.org/gene/4950:TDEL_0D06480 ^@ http://purl.uniprot.org/uniprot/G8ZUD8 ^@ Similarity ^@ Belongs to the proteasome subunit S14 family. http://togogenome.org/gene/4950:TDEL_0B01540 ^@ http://purl.uniprot.org/uniprot/G8ZNT9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/4950:TDEL_0E04770 ^@ http://purl.uniprot.org/uniprot/G8ZVS6 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0C02000 ^@ http://purl.uniprot.org/uniprot/G8ZRE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0B07350 ^@ http://purl.uniprot.org/uniprot/G8ZQH0 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Homodimer. http://togogenome.org/gene/4950:TDEL_0C05130 ^@ http://purl.uniprot.org/uniprot/G8ZSB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the low molecular weight phosphotyrosine protein phosphatase family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0A05730 ^@ http://purl.uniprot.org/uniprot/G8ZMR1 ^@ Similarity ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family. http://togogenome.org/gene/4950:TDEL_0G03500 ^@ http://purl.uniprot.org/uniprot/G8ZXV0 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/4950:TDEL_0H02780 ^@ http://purl.uniprot.org/uniprot/G8ZZU3 ^@ Similarity ^@ Belongs to the MAPRE family. http://togogenome.org/gene/4950:TDEL_0B05270 ^@ http://purl.uniprot.org/uniprot/G8ZPW2 ^@ Similarity ^@ Belongs to the OMP decarboxylase family. http://togogenome.org/gene/4950:TDEL_0G01040 ^@ http://purl.uniprot.org/uniprot/G8ZYJ6 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/4950:TDEL_0A02410 ^@ http://purl.uniprot.org/uniprot/G8ZLS9 ^@ Similarity ^@ Belongs to the PdxS/SNZ family. http://togogenome.org/gene/4950:TDEL_0E02170 ^@ http://purl.uniprot.org/uniprot/G8ZV16 ^@ Subcellular Location Annotation ^@ Golgi apparatus http://togogenome.org/gene/4950:TDEL_0A03800 ^@ http://purl.uniprot.org/uniprot/G8ZM68 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/4950:TDEL_0A00600 ^@ http://purl.uniprot.org/uniprot/G8ZL98 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/4950:TDEL_0H04240 ^@ http://purl.uniprot.org/uniprot/G9A089 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VTS1 family.|||Monomer. Binds to RNA.|||P-body|||cytosol http://togogenome.org/gene/4950:TDEL_0D00800 ^@ http://purl.uniprot.org/uniprot/G8ZSS0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/4950:TDEL_0E04780 ^@ http://purl.uniprot.org/uniprot/G8ZVS7 ^@ Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway. http://togogenome.org/gene/4950:TDEL_0B01250 ^@ http://purl.uniprot.org/uniprot/G8ZNR0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/4950:TDEL_0G02740 ^@ http://purl.uniprot.org/uniprot/G8ZZ16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0G00230 ^@ http://purl.uniprot.org/uniprot/G8ZYB5 ^@ Similarity ^@ Belongs to the BMT family. http://togogenome.org/gene/4950:TDEL_0G00430 ^@ http://purl.uniprot.org/uniprot/G8ZYD5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0G04500 ^@ http://purl.uniprot.org/uniprot/G8ZY50 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.|||Belongs to the TDD superfamily. TSR3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0C00200 ^@ http://purl.uniprot.org/uniprot/G8ZQW7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0B04080 ^@ http://purl.uniprot.org/uniprot/G8ZPJ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D05300 ^@ http://purl.uniprot.org/uniprot/G8ZU20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS4/SLD5 family.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication. http://togogenome.org/gene/4950:TDEL_0A04830 ^@ http://purl.uniprot.org/uniprot/G8ZMH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.|||Nucleus|||S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42. http://togogenome.org/gene/4950:TDEL_0B03860 ^@ http://purl.uniprot.org/uniprot/G8ZPH1 ^@ Function|||Similarity ^@ Belongs to the HisA/HisF family.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.|||In the C-terminal section; belongs to the HisA/HisF family. http://togogenome.org/gene/4950:TDEL_0G03440 ^@ http://purl.uniprot.org/uniprot/G8ZXU4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/4950:TDEL_0A07390 ^@ http://purl.uniprot.org/uniprot/G8ZN77 ^@ Function|||Similarity ^@ Belongs to the CTR86 family.|||Essential protein which may be involved in threonine biosynthesis. http://togogenome.org/gene/4950:TDEL_0D01560 ^@ http://purl.uniprot.org/uniprot/G8ZSZ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic60 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0A07180 ^@ http://purl.uniprot.org/uniprot/G8ZN56 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Heterooctamer of 4 alpha and 4 beta chains.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/4950:TDEL_0A01700 ^@ http://purl.uniprot.org/uniprot/G8ZLK8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SWC5 family.|||Component of the SWR1 chromatin remodeling complex.|||Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E03500 ^@ http://purl.uniprot.org/uniprot/G8ZVE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A06390 ^@ http://purl.uniprot.org/uniprot/G8ZMX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D05440 ^@ http://purl.uniprot.org/uniprot/G8ZU34 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/4950:TDEL_0C00440 ^@ http://purl.uniprot.org/uniprot/G8ZQZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS3 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0F02830 ^@ http://purl.uniprot.org/uniprot/G8ZWV0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0H02980 ^@ http://purl.uniprot.org/uniprot/G8ZZW3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0E04120 ^@ http://purl.uniprot.org/uniprot/G8ZVL1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0E04520 ^@ http://purl.uniprot.org/uniprot/G8ZVQ1 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/4950:TDEL_0D05320 ^@ http://purl.uniprot.org/uniprot/G8ZU22 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. http://togogenome.org/gene/4950:TDEL_0F02460 ^@ http://purl.uniprot.org/uniprot/G8ZWR3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WRB/GET1 family.|||Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. http://togogenome.org/gene/4950:TDEL_0A01400 ^@ http://purl.uniprot.org/uniprot/G8ZLH8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SLU7 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E04350 ^@ http://purl.uniprot.org/uniprot/G8ZVN4 ^@ Similarity ^@ Belongs to the HGH1 family. http://togogenome.org/gene/4950:TDEL_0F01650 ^@ http://purl.uniprot.org/uniprot/G8ZWI2 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/4950:TDEL_0A00350 ^@ http://purl.uniprot.org/uniprot/G8ZL73 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/4950:TDEL_0F03250 ^@ http://purl.uniprot.org/uniprot/G8ZWZ2 ^@ Similarity ^@ Belongs to the TEL2 family. http://togogenome.org/gene/4950:TDEL_0F00550 ^@ http://purl.uniprot.org/uniprot/G8ZW72 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/4950:TDEL_0B02860 ^@ http://purl.uniprot.org/uniprot/G8ZP71 ^@ Function|||Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.|||Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid. http://togogenome.org/gene/4950:TDEL_0B05750 ^@ http://purl.uniprot.org/uniprot/G8ZQ10 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/4950:TDEL_0C01220 ^@ http://purl.uniprot.org/uniprot/G8ZR69 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/4950:TDEL_0B02360 ^@ http://purl.uniprot.org/uniprot/G8ZP21 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/4950:TDEL_0B03270 ^@ http://purl.uniprot.org/uniprot/G8ZPB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0E02780 ^@ http://purl.uniprot.org/uniprot/G8ZV77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-O/MCM21 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C06090 ^@ http://purl.uniprot.org/uniprot/G8ZQL1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Membrane http://togogenome.org/gene/4950:TDEL_0H01490 ^@ http://purl.uniprot.org/uniprot/G8ZZG4 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily. http://togogenome.org/gene/4950:TDEL_0H03970 ^@ http://purl.uniprot.org/uniprot/G9A062 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/4950:TDEL_0B05780 ^@ http://purl.uniprot.org/uniprot/G8ZQ13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0B02670 ^@ http://purl.uniprot.org/uniprot/G8ZP52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOB1 family.|||Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.|||nucleolus http://togogenome.org/gene/4950:TDEL_0E00560 ^@ http://purl.uniprot.org/uniprot/G8ZUK5 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Homodimer. http://togogenome.org/gene/4950:TDEL_0D00970 ^@ http://purl.uniprot.org/uniprot/G8ZST7 ^@ Similarity ^@ Belongs to the type-1 OGG1 family. http://togogenome.org/gene/4950:TDEL_0E04250 ^@ http://purl.uniprot.org/uniprot/G8ZVM4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Cytoplasm|||Homotrimer.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E02030 ^@ http://purl.uniprot.org/uniprot/G8ZV02 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Cytoplasm|||In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily. http://togogenome.org/gene/4950:TDEL_0A02420 ^@ http://purl.uniprot.org/uniprot/G8ZLT0 ^@ Similarity ^@ Belongs to the glutaminase PdxT/SNO family. http://togogenome.org/gene/4950:TDEL_0E03660 ^@ http://purl.uniprot.org/uniprot/G8ZVG5 ^@ Similarity ^@ Belongs to the nucleoporin NSP1/NUP62 family. http://togogenome.org/gene/4950:TDEL_0D00160 ^@ http://purl.uniprot.org/uniprot/G8ZSK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/4950:TDEL_0D06060 ^@ http://purl.uniprot.org/uniprot/G8ZU96 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TPT transporter family. SLC35D subfamily.|||Cytoplasmic vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homooligomer.|||Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. http://togogenome.org/gene/4950:TDEL_0A02040 ^@ http://purl.uniprot.org/uniprot/G8ZLP2 ^@ Subcellular Location Annotation|||Subunit ^@ Component of the mitochondrial large ribosomal subunit.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0H02590 ^@ http://purl.uniprot.org/uniprot/G8ZZS4 ^@ Function|||Similarity ^@ Belongs to the RRT5 family.|||May be involved in the modulation of rDNA transcription. http://togogenome.org/gene/4950:TDEL_0B01440 ^@ http://purl.uniprot.org/uniprot/G8ZNS9 ^@ Function|||Similarity ^@ Belongs to the VPS16 family.|||Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology. http://togogenome.org/gene/4950:TDEL_0B03930 ^@ http://purl.uniprot.org/uniprot/G8ZPH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A01150 ^@ http://purl.uniprot.org/uniprot/G8ZLF3 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/4950:TDEL_0A06140 ^@ http://purl.uniprot.org/uniprot/G8ZMV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.|||kinetochore|||spindle http://togogenome.org/gene/4950:TDEL_0B06540 ^@ http://purl.uniprot.org/uniprot/G8ZQ89 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. http://togogenome.org/gene/4950:TDEL_0E01770 ^@ http://purl.uniprot.org/uniprot/G8ZUX6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0F00710 ^@ http://purl.uniprot.org/uniprot/G8ZW88 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0C04270 ^@ http://purl.uniprot.org/uniprot/G8ZS24 ^@ Similarity ^@ Belongs to the MAD2 family. http://togogenome.org/gene/4950:TDEL_0D02070 ^@ http://purl.uniprot.org/uniprot/G8ZT47 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/4950:TDEL_0C01240 ^@ http://purl.uniprot.org/uniprot/G8ZR71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YPI1 family.|||Nucleus|||Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control. http://togogenome.org/gene/4950:TDEL_0E00540 ^@ http://purl.uniprot.org/uniprot/G8ZUK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SSU72 phosphatase family.|||Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.|||Component of the cleavage and polyadenylation factor (CPF) complex.|||Nucleus|||Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1). http://togogenome.org/gene/4950:TDEL_0F03540 ^@ http://purl.uniprot.org/uniprot/G8ZX21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom5 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/4950:TDEL_0F04290 ^@ http://purl.uniprot.org/uniprot/G8ZX96 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A03660 ^@ http://purl.uniprot.org/uniprot/G8ZM54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Membrane|||Probably involved in transport through the plasma membrane. http://togogenome.org/gene/4950:TDEL_0H04220 ^@ http://purl.uniprot.org/uniprot/G9A087 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0B01140 ^@ http://purl.uniprot.org/uniprot/G8ZNP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0H01280 ^@ http://purl.uniprot.org/uniprot/G8ZZE3 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/4950:TDEL_0D01760 ^@ http://purl.uniprot.org/uniprot/G8ZT16 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the esterase D family.|||Cytoplasm|||Serine hydrolase involved in the detoxification of formaldehyde. http://togogenome.org/gene/4950:TDEL_0A04180 ^@ http://purl.uniprot.org/uniprot/G8ZMA6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.|||Mitochondrion|||Nucleus http://togogenome.org/gene/4950:TDEL_0F05450 ^@ http://purl.uniprot.org/uniprot/G8ZXL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. http://togogenome.org/gene/4950:TDEL_0D06360 ^@ http://purl.uniprot.org/uniprot/G8ZUC6 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/4950:TDEL_0D05850 ^@ http://purl.uniprot.org/uniprot/G8ZU75 ^@ Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family. http://togogenome.org/gene/4950:TDEL_0B04260 ^@ http://purl.uniprot.org/uniprot/G8ZPL1 ^@ Similarity ^@ Belongs to the alkylbase DNA glycosidase AlkA family. http://togogenome.org/gene/4950:TDEL_0A04250 ^@ http://purl.uniprot.org/uniprot/G8ZMB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D05050 ^@ http://purl.uniprot.org/uniprot/G8ZTZ5 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0D01370 ^@ http://purl.uniprot.org/uniprot/G8ZSX7 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/4950:TDEL_0F05250 ^@ http://purl.uniprot.org/uniprot/G8ZXJ2 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/4950:TDEL_0H01130 ^@ http://purl.uniprot.org/uniprot/G8ZZC8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FMP46 family.|||Mitochondrion|||Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules. http://togogenome.org/gene/4950:TDEL_0G04880 ^@ http://purl.uniprot.org/uniprot/G8ZY88 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/4950:TDEL_0A04450 ^@ http://purl.uniprot.org/uniprot/G8ZMD3 ^@ Function|||Subcellular Location Annotation ^@ Acts as component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B06950 ^@ http://purl.uniprot.org/uniprot/G8ZQD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcriptional coactivator PC4 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E01220 ^@ http://purl.uniprot.org/uniprot/G8ZUS1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/4950:TDEL_0B01360 ^@ http://purl.uniprot.org/uniprot/G8ZNS1 ^@ Cofactor|||Similarity ^@ Belongs to the alkaline phosphatase family.|||Binds 1 Mg(2+) ion.|||Binds 2 Zn(2+) ions. http://togogenome.org/gene/4950:TDEL_0A04970 ^@ http://purl.uniprot.org/uniprot/G8ZMI5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat CIA1 family.|||Cytoplasm|||Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.|||Interacts with NAR1.|||Nucleus http://togogenome.org/gene/4950:TDEL_0F01070 ^@ http://purl.uniprot.org/uniprot/G8ZWC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-3' exonuclease family.|||Cytoplasm|||Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. http://togogenome.org/gene/4950:TDEL_0E01870 ^@ http://purl.uniprot.org/uniprot/G8ZUY6 ^@ Function|||Similarity ^@ Belongs to the transaldolase family. Type 1 subfamily.|||Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate. http://togogenome.org/gene/4950:TDEL_0A04490 ^@ http://purl.uniprot.org/uniprot/G8ZMD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL40 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0G04700 ^@ http://purl.uniprot.org/uniprot/G8ZY70 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. http://togogenome.org/gene/4950:TDEL_0C05910 ^@ http://purl.uniprot.org/uniprot/G8ZSI8 ^@ Similarity ^@ Belongs to the SMC family. RAD50 subfamily. http://togogenome.org/gene/4950:TDEL_0F04720 ^@ http://purl.uniprot.org/uniprot/G8ZXD9 ^@ Function|||Similarity ^@ Belongs to the proline oxidase family.|||Converts proline to delta-1-pyrroline-5-carboxylate. http://togogenome.org/gene/4950:TDEL_0C05840 ^@ http://purl.uniprot.org/uniprot/G8ZSI1 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/4950:TDEL_0A00720 ^@ http://purl.uniprot.org/uniprot/G8ZLB0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RAP1 family.|||Homodimer.|||Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).|||Nucleus|||telomere http://togogenome.org/gene/4950:TDEL_0B02950 ^@ http://purl.uniprot.org/uniprot/G8ZP80 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 8 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D05100 ^@ http://purl.uniprot.org/uniprot/G8ZU00 ^@ Function|||Similarity ^@ Belongs to the HTP reductase family.|||Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate. http://togogenome.org/gene/4950:TDEL_0H00930 ^@ http://purl.uniprot.org/uniprot/G8ZZA8 ^@ Function|||Similarity ^@ ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.|||Belongs to the DEAD box helicase family. eIF4A subfamily. http://togogenome.org/gene/4950:TDEL_0F02590 ^@ http://purl.uniprot.org/uniprot/G8ZWS6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the myo-inositol oxygenase family.|||Binds 2 iron ions per subunit.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0B07450 ^@ http://purl.uniprot.org/uniprot/G8ZQI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARPC4 family.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.|||actin patch http://togogenome.org/gene/4950:TDEL_0G04810 ^@ http://purl.uniprot.org/uniprot/G8ZY81 ^@ Subcellular Location Annotation ^@ Membrane|||cell wall http://togogenome.org/gene/4950:TDEL_0A01840 ^@ http://purl.uniprot.org/uniprot/G8ZLM2 ^@ Similarity ^@ Belongs to the MYST (SAS/MOZ) family. http://togogenome.org/gene/4950:TDEL_0H02540 ^@ http://purl.uniprot.org/uniprot/G8ZZR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0H03360 ^@ http://purl.uniprot.org/uniprot/G9A001 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 72 family.|||Cell membrane|||Membrane|||Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. http://togogenome.org/gene/4950:TDEL_0A02740 ^@ http://purl.uniprot.org/uniprot/G8ZLW2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the pre-60S ribosomal particle.|||Belongs to the universal ribosomal protein uL10 family.|||Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.|||Cytoplasm|||nucleolus http://togogenome.org/gene/4950:TDEL_0G00410 ^@ http://purl.uniprot.org/uniprot/G8ZYD3 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/4950:TDEL_0G00580 ^@ http://purl.uniprot.org/uniprot/G8ZYF0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits. http://togogenome.org/gene/4950:TDEL_0H03610 ^@ http://purl.uniprot.org/uniprot/G9A026 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Nth/MutY family.|||Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.|||Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.|||Mitochondrion|||Nucleus http://togogenome.org/gene/4950:TDEL_0C01720 ^@ http://purl.uniprot.org/uniprot/G8ZRB9 ^@ Similarity ^@ Belongs to the anthranilate synthase component I family. http://togogenome.org/gene/4950:TDEL_0F04850 ^@ http://purl.uniprot.org/uniprot/G8ZXF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0F02520 ^@ http://purl.uniprot.org/uniprot/G8ZWR9 ^@ Similarity ^@ Belongs to the Fmt family. http://togogenome.org/gene/4950:TDEL_0F05050 ^@ http://purl.uniprot.org/uniprot/G8ZXH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCC2/Nipped-B family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G03190 ^@ http://purl.uniprot.org/uniprot/G8ZXR9 ^@ Similarity ^@ Belongs to the SIP5 family. http://togogenome.org/gene/4950:TDEL_0A03860 ^@ http://purl.uniprot.org/uniprot/G8ZM74 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/4950:TDEL_0G02030 ^@ http://purl.uniprot.org/uniprot/G8ZYU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KRE9/KNH1 family.|||Involved in cell wall beta(1->6) glucan synthesis.|||cell wall http://togogenome.org/gene/4950:TDEL_0E00180 ^@ http://purl.uniprot.org/uniprot/G8ZUG7 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/4950:TDEL_0E05680 ^@ http://purl.uniprot.org/uniprot/G8ZW17 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 81 family. http://togogenome.org/gene/4950:TDEL_0D06520 ^@ http://purl.uniprot.org/uniprot/G8ZUE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0C00480 ^@ http://purl.uniprot.org/uniprot/G8ZQZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM208 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0E01460 ^@ http://purl.uniprot.org/uniprot/G8ZUU5 ^@ Domain|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/4950:TDEL_0A02480 ^@ http://purl.uniprot.org/uniprot/G8ZLT6 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/4950:TDEL_0F01250 ^@ http://purl.uniprot.org/uniprot/G8ZWE2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0B02270 ^@ http://purl.uniprot.org/uniprot/G8ZP12 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/4950:TDEL_0F04480 ^@ http://purl.uniprot.org/uniprot/G8ZXB5 ^@ Function ^@ Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. http://togogenome.org/gene/4950:TDEL_0E02200 ^@ http://purl.uniprot.org/uniprot/G8ZV19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BIG1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0B05420 ^@ http://purl.uniprot.org/uniprot/G8ZPX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0F02860 ^@ http://purl.uniprot.org/uniprot/G8ZWV3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0B04490 ^@ http://purl.uniprot.org/uniprot/G8ZPN4 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/4950:TDEL_0D04030 ^@ http://purl.uniprot.org/uniprot/G8ZTP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0C02130 ^@ http://purl.uniprot.org/uniprot/G8ZRG0 ^@ Function|||Similarity ^@ Belongs to the WD repeat DDB2/WDR76 family.|||DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes. http://togogenome.org/gene/4950:TDEL_0A05610 ^@ http://purl.uniprot.org/uniprot/G8ZMP9 ^@ Similarity ^@ Belongs to the beclin family. http://togogenome.org/gene/4950:TDEL_0C03720 ^@ http://purl.uniprot.org/uniprot/G8ZRW9 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/4950:TDEL_0B04450 ^@ http://purl.uniprot.org/uniprot/G8ZPN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RFT1 family.|||Endoplasmic reticulum membrane|||May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane.|||Membrane http://togogenome.org/gene/4950:TDEL_0H02890 ^@ http://purl.uniprot.org/uniprot/G8ZZV4 ^@ Similarity ^@ Belongs to the adaptor complexes medium subunit family. http://togogenome.org/gene/4950:TDEL_0D00460 ^@ http://purl.uniprot.org/uniprot/G8ZSN6 ^@ Similarity ^@ Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. http://togogenome.org/gene/4950:TDEL_0D01230 ^@ http://purl.uniprot.org/uniprot/G8ZSW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ThrE exporter (TC 2.A.79) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0F01630 ^@ http://purl.uniprot.org/uniprot/G8ZWI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NPR3 family.|||Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0H02600 ^@ http://purl.uniprot.org/uniprot/G8ZZS5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/4950:TDEL_0D00490 ^@ http://purl.uniprot.org/uniprot/G8ZSN9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/4950:TDEL_0G03640 ^@ http://purl.uniprot.org/uniprot/G8ZXW4 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/4950:TDEL_0E05050 ^@ http://purl.uniprot.org/uniprot/G8ZVV4 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/4950:TDEL_0D05250 ^@ http://purl.uniprot.org/uniprot/G8ZU15 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Mitochondrion inner membrane|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. http://togogenome.org/gene/4950:TDEL_0F04820 ^@ http://purl.uniprot.org/uniprot/G8ZXE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/4950:TDEL_0F04220 ^@ http://purl.uniprot.org/uniprot/G8ZX89 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the midasin family.|||Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.|||nucleolus|||nucleoplasm http://togogenome.org/gene/4950:TDEL_0C04530 ^@ http://purl.uniprot.org/uniprot/G8ZS50 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/4950:TDEL_0A07320 ^@ http://purl.uniprot.org/uniprot/G8ZN70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Sterol O-acyltransferase that catalyzes the formation of stery esters. http://togogenome.org/gene/4950:TDEL_0A06680 ^@ http://purl.uniprot.org/uniprot/G8ZN06 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/4950:TDEL_0A03600 ^@ http://purl.uniprot.org/uniprot/G8ZM48 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/4950:TDEL_0H02160 ^@ http://purl.uniprot.org/uniprot/G8ZZN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0C06210 ^@ http://purl.uniprot.org/uniprot/G8ZQM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid/polyamine transporter 2 family.|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0B00780 ^@ http://purl.uniprot.org/uniprot/G8ZNL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0C04100 ^@ http://purl.uniprot.org/uniprot/G8ZS07 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/4950:TDEL_0C05120 ^@ http://purl.uniprot.org/uniprot/G8ZSA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.|||Belongs to the CNOT2/3/5 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0D05670 ^@ http://purl.uniprot.org/uniprot/G8ZU57 ^@ Function|||Similarity ^@ Belongs to the peptidase T1A family.|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. http://togogenome.org/gene/4950:TDEL_0H04250 ^@ http://purl.uniprot.org/uniprot/G9A090 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/4950:TDEL_0D00480 ^@ http://purl.uniprot.org/uniprot/G8ZSN8 ^@ Similarity ^@ Belongs to the TTI2 family. http://togogenome.org/gene/4950:TDEL_0A00620 ^@ http://purl.uniprot.org/uniprot/G8ZLA0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/4950:TDEL_0E03010 ^@ http://purl.uniprot.org/uniprot/G8ZVA0 ^@ Function ^@ Cleaves A-5'-PPP-5'A to yield AMP and ADP. Can cleave all dinucleoside polyphosphates, provided the phosphate chain contains at least 3 phosphates and that 1 of the 2 bases composing the nucleotide is a purine. Is most effective on dinucleoside triphosphates. Negatively regulates intracellular dinucleoside polyphosphate levels, which elevate following heat shock. http://togogenome.org/gene/4950:TDEL_0A01110 ^@ http://purl.uniprot.org/uniprot/G8ZLE9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/4950:TDEL_0D04300 ^@ http://purl.uniprot.org/uniprot/G8ZTS0 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/4950:TDEL_0D03780 ^@ http://purl.uniprot.org/uniprot/G8ZTL8 ^@ Similarity ^@ Belongs to the chaperonin (HSP60) family. http://togogenome.org/gene/4950:TDEL_0C06840 ^@ http://purl.uniprot.org/uniprot/G8ZQT6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KRE28 family.|||Involved in kinetochore-microtubule binding and the spindle assembly checkpoint.|||Nucleus membrane|||kinetochore|||spindle pole body http://togogenome.org/gene/4950:TDEL_0B05100 ^@ http://purl.uniprot.org/uniprot/G8ZPU5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.|||Chromosome|||Component of the COMPASS (Set1C) complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D04370 ^@ http://purl.uniprot.org/uniprot/G8ZTS7 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Fibrillarin family. http://togogenome.org/gene/4950:TDEL_0G00700 ^@ http://purl.uniprot.org/uniprot/G8ZYG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B1 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E03800 ^@ http://purl.uniprot.org/uniprot/G8ZVH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0D06110 ^@ http://purl.uniprot.org/uniprot/G8ZUA1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST5 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/4950:TDEL_0B05670 ^@ http://purl.uniprot.org/uniprot/G8ZQ02 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/4950:TDEL_0H02680 ^@ http://purl.uniprot.org/uniprot/G8ZZT3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cut8/STS1 family.|||Binds the proteasome.|||Cytoplasm|||Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A03420 ^@ http://purl.uniprot.org/uniprot/G8ZM30 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/4950:TDEL_0C02560 ^@ http://purl.uniprot.org/uniprot/G8ZRK3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 16 family. http://togogenome.org/gene/4950:TDEL_0E00530 ^@ http://purl.uniprot.org/uniprot/G8ZUK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cytoplasm|||Nucleus|||Preautophagosomal structure|||Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. http://togogenome.org/gene/4950:TDEL_0C01570 ^@ http://purl.uniprot.org/uniprot/G8ZRA4 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/4950:TDEL_0E00390 ^@ http://purl.uniprot.org/uniprot/G8ZUI8 ^@ Similarity ^@ Belongs to the NARF family. http://togogenome.org/gene/4950:TDEL_0B00300 ^@ http://purl.uniprot.org/uniprot/G8ZNG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family.|||Mitochondrion membrane http://togogenome.org/gene/4950:TDEL_0H02960 ^@ http://purl.uniprot.org/uniprot/G8ZZW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0F03140 ^@ http://purl.uniprot.org/uniprot/G8ZWY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM MRD1 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A01650 ^@ http://purl.uniprot.org/uniprot/G8ZLK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||actin patch http://togogenome.org/gene/4950:TDEL_0G04530 ^@ http://purl.uniprot.org/uniprot/G8ZY53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||spindle http://togogenome.org/gene/4950:TDEL_0E03030 ^@ http://purl.uniprot.org/uniprot/G8ZVA2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 6 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C06470 ^@ http://purl.uniprot.org/uniprot/G8ZQP9 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/4950:TDEL_0H02830 ^@ http://purl.uniprot.org/uniprot/G8ZZU8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. http://togogenome.org/gene/4950:TDEL_0B02570 ^@ http://purl.uniprot.org/uniprot/G8ZP42 ^@ Cofactor|||Subcellular Location Annotation ^@ Binds 1 heme c group covalently per subunit.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0F00370 ^@ http://purl.uniprot.org/uniprot/G8ZW54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC3 family.|||Endoplasmic reticulum membrane|||Membrane|||The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). http://togogenome.org/gene/4950:TDEL_0F03200 ^@ http://purl.uniprot.org/uniprot/G8ZWY7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D02740 ^@ http://purl.uniprot.org/uniprot/G8ZTB4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/4950:TDEL_0B03110 ^@ http://purl.uniprot.org/uniprot/G8ZP96 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.|||Membrane http://togogenome.org/gene/4950:TDEL_0A06040 ^@ http://purl.uniprot.org/uniprot/G8ZMU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OSBP family.|||Membrane http://togogenome.org/gene/4950:TDEL_0E05230 ^@ http://purl.uniprot.org/uniprot/G8ZVX2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/4950:TDEL_0E00780 ^@ http://purl.uniprot.org/uniprot/G8ZUM7 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/4950:TDEL_0F03040 ^@ http://purl.uniprot.org/uniprot/G8ZWX1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0A03430 ^@ http://purl.uniprot.org/uniprot/G8ZM31 ^@ Similarity ^@ Belongs to the thiamine pyrophosphokinase family. http://togogenome.org/gene/4950:TDEL_0C02970 ^@ http://purl.uniprot.org/uniprot/G8ZRP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0B00430 ^@ http://purl.uniprot.org/uniprot/G8ZNH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERCC1/RAD10/SWI10 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D06580 ^@ http://purl.uniprot.org/uniprot/G8ZUE8 ^@ Caution|||Similarity ^@ Belongs to the globin family.|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/4950:TDEL_0F01080 ^@ http://purl.uniprot.org/uniprot/G8ZWC5 ^@ Subcellular Location Annotation ^@ Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/4950:TDEL_0C02290 ^@ http://purl.uniprot.org/uniprot/G8ZRH6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm|||Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. http://togogenome.org/gene/4950:TDEL_0F05360 ^@ http://purl.uniprot.org/uniprot/G8ZXK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D03050 ^@ http://purl.uniprot.org/uniprot/G8ZTE5 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/4950:TDEL_0C02940 ^@ http://purl.uniprot.org/uniprot/G8ZRP1 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin C subfamily. http://togogenome.org/gene/4950:TDEL_0C06150 ^@ http://purl.uniprot.org/uniprot/G8ZQL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAM41 family.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0F00350 ^@ http://purl.uniprot.org/uniprot/G8ZW52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.|||Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/4950:TDEL_0C02100 ^@ http://purl.uniprot.org/uniprot/G8ZRF7 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/4950:TDEL_0A02960 ^@ http://purl.uniprot.org/uniprot/G8ZLY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Peroxisome http://togogenome.org/gene/4950:TDEL_0C03750 ^@ http://purl.uniprot.org/uniprot/G8ZRX2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/4950:TDEL_0F03660 ^@ http://purl.uniprot.org/uniprot/G8ZX33 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS36 family.|||Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II).|||Cytoplasm|||Endosome http://togogenome.org/gene/4950:TDEL_0H03690 ^@ http://purl.uniprot.org/uniprot/G9A034 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic GSH synthase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/4950:TDEL_0G01400 ^@ http://purl.uniprot.org/uniprot/G8ZYN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS33 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0E03810 ^@ http://purl.uniprot.org/uniprot/G8ZVI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS53 family.|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/4950:TDEL_0F03080 ^@ http://purl.uniprot.org/uniprot/G8ZWX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAP family.|||nucleolus http://togogenome.org/gene/4950:TDEL_0C00860 ^@ http://purl.uniprot.org/uniprot/G8ZR33 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0A03170 ^@ http://purl.uniprot.org/uniprot/G8ZM05 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/4950:TDEL_0G02850 ^@ http://purl.uniprot.org/uniprot/G8ZXN5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting. Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance.|||Belongs to the arsA ATPase family.|||Cytoplasm|||Endoplasmic reticulum|||Golgi apparatus|||Homodimer. Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer. Interacts with the chloride channel protein GEF1. http://togogenome.org/gene/4950:TDEL_0A04940 ^@ http://purl.uniprot.org/uniprot/G8ZMI2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pex2/pex10/pex12 family.|||Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/4950:TDEL_0B06600 ^@ http://purl.uniprot.org/uniprot/G8ZQ95 ^@ Function|||Similarity ^@ Belongs to the BLI1 family.|||Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting. http://togogenome.org/gene/4950:TDEL_0C03810 ^@ http://purl.uniprot.org/uniprot/G8ZRX8 ^@ Similarity ^@ Belongs to the PIGH family. http://togogenome.org/gene/4950:TDEL_0G02520 ^@ http://purl.uniprot.org/uniprot/G8ZYZ4 ^@ Similarity ^@ Belongs to the IWR1/SLC7A6OS family. http://togogenome.org/gene/4950:TDEL_0C03310 ^@ http://purl.uniprot.org/uniprot/G8ZRS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0B06020 ^@ http://purl.uniprot.org/uniprot/G8ZQ37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0D03230 ^@ http://purl.uniprot.org/uniprot/G8ZTG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPS2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0B01790 ^@ http://purl.uniprot.org/uniprot/G8ZNW4 ^@ Similarity ^@ Belongs to the HMBS family. http://togogenome.org/gene/4950:TDEL_0B06880 ^@ http://purl.uniprot.org/uniprot/G8ZQC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family. IMP2 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0B03050 ^@ http://purl.uniprot.org/uniprot/G8ZP90 ^@ Similarity ^@ Belongs to the glycosyltransferase 15 family. http://togogenome.org/gene/4950:TDEL_0A05560 ^@ http://purl.uniprot.org/uniprot/G8ZMP4 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/4950:TDEL_0F04430 ^@ http://purl.uniprot.org/uniprot/G8ZXB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat peroxin-7 family.|||Peroxisome matrix|||cytosol http://togogenome.org/gene/4950:TDEL_0G03480 ^@ http://purl.uniprot.org/uniprot/G8ZXU8 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/4950:TDEL_0D00960 ^@ http://purl.uniprot.org/uniprot/G8ZST6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the helicase family. PIF1 subfamily.|||DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Involved in the maintenance of ribosomal (rDNA). Required for efficient fork arrest at the replicaion fork barrier within rDNA. Involved in the maintenance of mitochondrial (mtDNA). Required to maintain mtDNA under conditions that introduce dsDNA breaks in mtDNA, either preventing or repairing dsDNA breaks. May inhibit replication progression to allow time for repair. May have a general role in chromosomal replication by affecting Okazaki fragment maturation. May have a role in conjunction with DNA2 helicase/nuclease in 5'-flap extension during Okazaki fragment processing.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion|||Monomer. Interacts with telomerase.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A05000 ^@ http://purl.uniprot.org/uniprot/G8ZMI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat HIR1 family.|||Nucleus|||Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle. http://togogenome.org/gene/4950:TDEL_0A01350 ^@ http://purl.uniprot.org/uniprot/G8ZLH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0B06430 ^@ http://purl.uniprot.org/uniprot/G8ZQ78 ^@ Similarity ^@ Belongs to the adaptor complexes medium subunit family. http://togogenome.org/gene/4950:TDEL_0B05110 ^@ http://purl.uniprot.org/uniprot/G8ZPU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC6 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G00720 ^@ http://purl.uniprot.org/uniprot/G8ZYG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP5 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0E04730 ^@ http://purl.uniprot.org/uniprot/G8ZVS2 ^@ Similarity ^@ Belongs to the eIF-2-alpha family. http://togogenome.org/gene/4950:TDEL_0A04430 ^@ http://purl.uniprot.org/uniprot/G8ZMD1 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/4950:TDEL_0C02500 ^@ http://purl.uniprot.org/uniprot/G8ZRJ7 ^@ Similarity ^@ Belongs to the threonine aldolase family. http://togogenome.org/gene/4950:TDEL_0D01090 ^@ http://purl.uniprot.org/uniprot/G8ZSU9 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/4950:TDEL_0A03810 ^@ http://purl.uniprot.org/uniprot/G8ZM69 ^@ Similarity ^@ Belongs to the peptidase M28 family. http://togogenome.org/gene/4950:TDEL_0B01990 ^@ http://purl.uniprot.org/uniprot/G8ZNY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCC1 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0F05650 ^@ http://purl.uniprot.org/uniprot/G8ZXN2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0A04040 ^@ http://purl.uniprot.org/uniprot/G8ZM92 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M16 family. PreP subfamily.|||Mitochondrion intermembrane space|||Mitochondrion matrix|||Monomer and homodimer; homodimerization is induced by binding of the substrate. http://togogenome.org/gene/4950:TDEL_0G00740 ^@ http://purl.uniprot.org/uniprot/G8ZYG6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D02700 ^@ http://purl.uniprot.org/uniprot/G8ZTB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the importin beta family. Importin beta-1 subfamily.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0B05170 ^@ http://purl.uniprot.org/uniprot/G8ZPV2 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DCP2 subfamily. http://togogenome.org/gene/4950:TDEL_0E02940 ^@ http://purl.uniprot.org/uniprot/G8ZV93 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 3 family. http://togogenome.org/gene/4950:TDEL_0A03610 ^@ http://purl.uniprot.org/uniprot/G8ZM49 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/4950:TDEL_0F04830 ^@ http://purl.uniprot.org/uniprot/G8ZXF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS18 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D00720 ^@ http://purl.uniprot.org/uniprot/G8ZSR2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/4950:TDEL_0A07170 ^@ http://purl.uniprot.org/uniprot/G8ZN55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INP1 family.|||Membrane|||Peroxisome membrane|||Required for peroxisome inheritance. http://togogenome.org/gene/4950:TDEL_0F03980 ^@ http://purl.uniprot.org/uniprot/G8ZX65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0F02640 ^@ http://purl.uniprot.org/uniprot/G8ZWT1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/4950:TDEL_0C02550 ^@ http://purl.uniprot.org/uniprot/G8ZRK2 ^@ Similarity ^@ Belongs to the NAD kinase family. http://togogenome.org/gene/4950:TDEL_0C03180 ^@ http://purl.uniprot.org/uniprot/G8ZRR5 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/4950:TDEL_0E01250 ^@ http://purl.uniprot.org/uniprot/G8ZUS4 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/4950:TDEL_0D02220 ^@ http://purl.uniprot.org/uniprot/G8ZT62 ^@ Similarity ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. http://togogenome.org/gene/4950:TDEL_0A04340 ^@ http://purl.uniprot.org/uniprot/G8ZMC2 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/4950:TDEL_0G00140 ^@ http://purl.uniprot.org/uniprot/G8ZYA6 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/4950:TDEL_0A03650 ^@ http://purl.uniprot.org/uniprot/G8ZM53 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ISN1 family.|||Homotetramer.|||IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation. http://togogenome.org/gene/4950:TDEL_0B02640 ^@ http://purl.uniprot.org/uniprot/G8ZP49 ^@ Similarity ^@ Belongs to the UPF0538 family. http://togogenome.org/gene/4950:TDEL_0A07270 ^@ http://purl.uniprot.org/uniprot/G8ZN65 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0D02400 ^@ http://purl.uniprot.org/uniprot/G8ZT80 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/4950:TDEL_0E04510 ^@ http://purl.uniprot.org/uniprot/G8ZVQ0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/4950:TDEL_0A05390 ^@ http://purl.uniprot.org/uniprot/G8ZMM7 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/4950:TDEL_0H01480 ^@ http://purl.uniprot.org/uniprot/G8ZZG3 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/4950:TDEL_0A00120 ^@ http://purl.uniprot.org/uniprot/G8ZL50 ^@ Similarity ^@ Belongs to the FMO family. http://togogenome.org/gene/4950:TDEL_0C02790 ^@ http://purl.uniprot.org/uniprot/G8ZRM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. ATM subfamily.|||Nucleus|||Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.|||telomere http://togogenome.org/gene/4950:TDEL_0A05080 ^@ http://purl.uniprot.org/uniprot/G8ZMJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Membrane http://togogenome.org/gene/4950:TDEL_0E01600 ^@ http://purl.uniprot.org/uniprot/G8ZUV9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/4950:TDEL_0C02620 ^@ http://purl.uniprot.org/uniprot/G8ZRK9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C05630 ^@ http://purl.uniprot.org/uniprot/G8ZSG0 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/4950:TDEL_0C02200 ^@ http://purl.uniprot.org/uniprot/G8ZRG7 ^@ Similarity ^@ Belongs to the proteasome subunit p55 family. http://togogenome.org/gene/4950:TDEL_0B00240 ^@ http://purl.uniprot.org/uniprot/G8ZNF9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Component of the GSE complex.|||GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions. http://togogenome.org/gene/4950:TDEL_0C00500 ^@ http://purl.uniprot.org/uniprot/G8ZQZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A00530 ^@ http://purl.uniprot.org/uniprot/G8ZL91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 72 family.|||Cell membrane|||Membrane|||Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. http://togogenome.org/gene/4950:TDEL_0G03690 ^@ http://purl.uniprot.org/uniprot/G8ZXW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/4950:TDEL_0E01710 ^@ http://purl.uniprot.org/uniprot/G8ZUX0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/4950:TDEL_0A00930 ^@ http://purl.uniprot.org/uniprot/G8ZLD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Bud neck http://togogenome.org/gene/4950:TDEL_0E01290 ^@ http://purl.uniprot.org/uniprot/G8ZUS8 ^@ Similarity ^@ Belongs to the VAC14 family. http://togogenome.org/gene/4950:TDEL_0C05070 ^@ http://purl.uniprot.org/uniprot/G8ZSA4 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/4950:TDEL_0E00440 ^@ http://purl.uniprot.org/uniprot/G8ZUJ3 ^@ Caution|||Similarity ^@ Belongs to the globin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/4950:TDEL_0C00190 ^@ http://purl.uniprot.org/uniprot/G8ZQW6 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/4950:TDEL_0D05240 ^@ http://purl.uniprot.org/uniprot/G8ZU14 ^@ Similarity ^@ Belongs to the VPS72/YL1 family. http://togogenome.org/gene/4950:TDEL_0C06350 ^@ http://purl.uniprot.org/uniprot/G8ZQN7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0B05880 ^@ http://purl.uniprot.org/uniprot/G8ZQ23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0H02570 ^@ http://purl.uniprot.org/uniprot/G8ZZS2 ^@ Similarity ^@ Belongs to the UQCRH/QCR6 family. http://togogenome.org/gene/4950:TDEL_0D03480 ^@ http://purl.uniprot.org/uniprot/G8ZTI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.|||Cytoplasm|||Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. http://togogenome.org/gene/4950:TDEL_0E02720 ^@ http://purl.uniprot.org/uniprot/G8ZV71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OSBP family.|||Membrane http://togogenome.org/gene/4950:TDEL_0E04210 ^@ http://purl.uniprot.org/uniprot/G8ZVM0 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/4950:TDEL_0B01880 ^@ http://purl.uniprot.org/uniprot/G8ZNX3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Forms a complex with TRM82.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G00750 ^@ http://purl.uniprot.org/uniprot/G8ZYG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.|||Nucleus http://togogenome.org/gene/4950:TDEL_0H00900 ^@ http://purl.uniprot.org/uniprot/G8ZZA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E01310 ^@ http://purl.uniprot.org/uniprot/G8ZUT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP1/IKA1 family.|||Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0F04930 ^@ http://purl.uniprot.org/uniprot/G8ZXG0 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/4950:TDEL_0A06950 ^@ http://purl.uniprot.org/uniprot/G8ZN33 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/4950:TDEL_0D01060 ^@ http://purl.uniprot.org/uniprot/G8ZSU6 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/4950:TDEL_0A02290 ^@ http://purl.uniprot.org/uniprot/G8ZLR7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0C03430 ^@ http://purl.uniprot.org/uniprot/G8ZRU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0C01410 ^@ http://purl.uniprot.org/uniprot/G8ZR88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0F00130 ^@ http://purl.uniprot.org/uniprot/G8ZW30 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0B01570 ^@ http://purl.uniprot.org/uniprot/G8ZNU2 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/4950:TDEL_0D05010 ^@ http://purl.uniprot.org/uniprot/G8ZTZ1 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/4950:TDEL_0E01450 ^@ http://purl.uniprot.org/uniprot/G8ZUU4 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/4950:TDEL_0H03740 ^@ http://purl.uniprot.org/uniprot/G9A039 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A05840 ^@ http://purl.uniprot.org/uniprot/G8ZMS2 ^@ Similarity ^@ Belongs to the peptidase S9B family. http://togogenome.org/gene/4950:TDEL_0F00270 ^@ http://purl.uniprot.org/uniprot/G8ZW44 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/4950:TDEL_0B07050 ^@ http://purl.uniprot.org/uniprot/G8ZQE0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSM3 family.|||Component of the fork protection complex (FPC) consisting of TOF1 and CSM3.|||Nucleus|||Plays an important role in the control of DNA replication and the maintenance of replication fork stability. http://togogenome.org/gene/4950:TDEL_0C05270 ^@ http://purl.uniprot.org/uniprot/G8ZSC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG14 family.|||Membrane|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0E03350 ^@ http://purl.uniprot.org/uniprot/G8ZVD4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NADPH--cytochrome P450 reductase family.|||Binds 1 FAD per monomer.|||Binds 1 FMN per monomer.|||Cell membrane|||Endoplasmic reticulum membrane|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion outer membrane|||This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. http://togogenome.org/gene/4950:TDEL_0C01730 ^@ http://purl.uniprot.org/uniprot/G8ZRC0 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/4950:TDEL_0H00640 ^@ http://purl.uniprot.org/uniprot/G8ZZ79 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/4950:TDEL_0E04540 ^@ http://purl.uniprot.org/uniprot/G8ZVQ3 ^@ Similarity ^@ Belongs to the DNA polymerase delta/II small subunit family. http://togogenome.org/gene/4950:TDEL_0E01980 ^@ http://purl.uniprot.org/uniprot/G8ZUZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DSS1/SEM1 family.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D03210 ^@ http://purl.uniprot.org/uniprot/G8ZTG1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm|||Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. http://togogenome.org/gene/4950:TDEL_0B06080 ^@ http://purl.uniprot.org/uniprot/G8ZQ43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bL27 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0H02840 ^@ http://purl.uniprot.org/uniprot/G8ZZU9 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/4950:TDEL_0F05570 ^@ http://purl.uniprot.org/uniprot/G8ZXM4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RFT1 family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane.|||Membrane http://togogenome.org/gene/4950:TDEL_0E05310 ^@ http://purl.uniprot.org/uniprot/G8ZVY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.|||kinetochore|||spindle http://togogenome.org/gene/4950:TDEL_0D03900 ^@ http://purl.uniprot.org/uniprot/G8ZTN0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS1/PSF1 family.|||Component of the GINS complex.|||Nucleus|||Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. http://togogenome.org/gene/4950:TDEL_0C06730 ^@ http://purl.uniprot.org/uniprot/G8ZQS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MGR1 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0F02210 ^@ http://purl.uniprot.org/uniprot/G8ZWN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A07010 ^@ http://purl.uniprot.org/uniprot/G8ZN39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0E03060 ^@ http://purl.uniprot.org/uniprot/G8ZVA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM24 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0B02090 ^@ http://purl.uniprot.org/uniprot/G8ZNZ4 ^@ Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0A04440 ^@ http://purl.uniprot.org/uniprot/G8ZMD2 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/4950:TDEL_0A02050 ^@ http://purl.uniprot.org/uniprot/G8ZLP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion inner membrane|||Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration. http://togogenome.org/gene/4950:TDEL_0D05620 ^@ http://purl.uniprot.org/uniprot/G8ZU52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0H04460 ^@ http://purl.uniprot.org/uniprot/G9A0B1 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0A01910 ^@ http://purl.uniprot.org/uniprot/G8ZLM9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/4950:TDEL_0B04440 ^@ http://purl.uniprot.org/uniprot/G8ZPM9 ^@ Similarity ^@ Belongs to the NFYB/HAP3 subunit family. http://togogenome.org/gene/4950:TDEL_0C05850 ^@ http://purl.uniprot.org/uniprot/G8ZSI2 ^@ Function ^@ Involved in pre-mRNA splicing. http://togogenome.org/gene/4950:TDEL_0H00310 ^@ http://purl.uniprot.org/uniprot/G8ZZ46 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum|||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins. http://togogenome.org/gene/4950:TDEL_0E00940 ^@ http://purl.uniprot.org/uniprot/G8ZUP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histidine acid phosphatase family. VIP1 subfamily.|||Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).|||cytoskeleton http://togogenome.org/gene/4950:TDEL_0C06430 ^@ http://purl.uniprot.org/uniprot/G8ZQP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTA1 family.|||Cytoplasm|||Endosome membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0D05060 ^@ http://purl.uniprot.org/uniprot/G8ZTZ6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/4950:TDEL_0A07940 ^@ http://purl.uniprot.org/uniprot/G8ZND2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G00180 ^@ http://purl.uniprot.org/uniprot/G8ZYB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D02380 ^@ http://purl.uniprot.org/uniprot/G8ZT78 ^@ Similarity ^@ Belongs to the RNR ribonuclease family. http://togogenome.org/gene/4950:TDEL_0B07360 ^@ http://purl.uniprot.org/uniprot/G8ZQH1 ^@ Similarity ^@ Belongs to the sulfiredoxin family. http://togogenome.org/gene/4950:TDEL_0A05630 ^@ http://purl.uniprot.org/uniprot/G8ZMQ1 ^@ Similarity ^@ Belongs to the NOC2 family. http://togogenome.org/gene/4950:TDEL_0H04540 ^@ http://purl.uniprot.org/uniprot/G9A0B9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/4950:TDEL_0D05530 ^@ http://purl.uniprot.org/uniprot/G8ZU43 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D06500 ^@ http://purl.uniprot.org/uniprot/G8ZUE0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0F01530 ^@ http://purl.uniprot.org/uniprot/G8ZWH0 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. http://togogenome.org/gene/4950:TDEL_0A01460 ^@ http://purl.uniprot.org/uniprot/G8ZLI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Golgi apparatus membrane|||Golgi membrane protein involved in vesicular trafficking.|||Membrane http://togogenome.org/gene/4950:TDEL_0B06530 ^@ http://purl.uniprot.org/uniprot/G8ZQ88 ^@ Similarity ^@ Belongs to the EFG1/PHD1/stuA family. http://togogenome.org/gene/4950:TDEL_0G00670 ^@ http://purl.uniprot.org/uniprot/G8ZYF9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. BUD32 family.|||Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.|||telomere http://togogenome.org/gene/4950:TDEL_0D01730 ^@ http://purl.uniprot.org/uniprot/G8ZT13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat UTP18 family.|||nucleolus http://togogenome.org/gene/4950:TDEL_0B03800 ^@ http://purl.uniprot.org/uniprot/G8ZPG5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA.|||Belongs to the CAF20 family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0D02560 ^@ http://purl.uniprot.org/uniprot/G8ZT96 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ7 family.|||Binds 2 iron ions per subunit.|||Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0G03520 ^@ http://purl.uniprot.org/uniprot/G8ZXV2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D06570 ^@ http://purl.uniprot.org/uniprot/G8ZUE7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0G02820 ^@ http://purl.uniprot.org/uniprot/G8ZZ24 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily. http://togogenome.org/gene/4950:TDEL_0A07560 ^@ http://purl.uniprot.org/uniprot/G8ZN94 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/4950:TDEL_0E00970 ^@ http://purl.uniprot.org/uniprot/G8ZUP6 ^@ Similarity ^@ Belongs to the BLOC1S1 family. http://togogenome.org/gene/4950:TDEL_0C04160 ^@ http://purl.uniprot.org/uniprot/G8ZS13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRM6/GCD10 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C04130 ^@ http://purl.uniprot.org/uniprot/G8ZS10 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family. http://togogenome.org/gene/4950:TDEL_0D01770 ^@ http://purl.uniprot.org/uniprot/G8ZT17 ^@ Similarity ^@ Belongs to the PAF1 family. http://togogenome.org/gene/4950:TDEL_0C00970 ^@ http://purl.uniprot.org/uniprot/G8ZR44 ^@ Similarity ^@ Belongs to the BLM10 family. http://togogenome.org/gene/4950:TDEL_0B04700 ^@ http://purl.uniprot.org/uniprot/G8ZPQ5 ^@ Subcellular Location Annotation ^@ Membrane|||Preautophagosomal structure membrane http://togogenome.org/gene/4950:TDEL_0A03820 ^@ http://purl.uniprot.org/uniprot/G8ZM70 ^@ Similarity ^@ Belongs to the V-ATPase D subunit family. http://togogenome.org/gene/4950:TDEL_0G00370 ^@ http://purl.uniprot.org/uniprot/G8ZYC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 48 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0F01500 ^@ http://purl.uniprot.org/uniprot/G8ZWG7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0B06580 ^@ http://purl.uniprot.org/uniprot/G8ZQ93 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 76 family. http://togogenome.org/gene/4950:TDEL_0D05200 ^@ http://purl.uniprot.org/uniprot/G8ZU10 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/4950:TDEL_0D03840 ^@ http://purl.uniprot.org/uniprot/G8ZTM4 ^@ Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. http://togogenome.org/gene/4950:TDEL_0H03710 ^@ http://purl.uniprot.org/uniprot/G9A036 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0A02100 ^@ http://purl.uniprot.org/uniprot/G8ZLP8 ^@ Similarity ^@ Belongs to the SOS response-associated peptidase family. http://togogenome.org/gene/4950:TDEL_0A03950 ^@ http://purl.uniprot.org/uniprot/G8ZM83 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.|||Belongs to the dynein light chain family.|||Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).|||cytoskeleton|||nuclear pore complex http://togogenome.org/gene/4950:TDEL_0H02090 ^@ http://purl.uniprot.org/uniprot/G8ZZM4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. http://togogenome.org/gene/4950:TDEL_0H03700 ^@ http://purl.uniprot.org/uniprot/G9A035 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 15 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E03410 ^@ http://purl.uniprot.org/uniprot/G8ZVE0 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/4950:TDEL_0H03420 ^@ http://purl.uniprot.org/uniprot/G9A007 ^@ Similarity ^@ Belongs to the TOP6A family. http://togogenome.org/gene/4950:TDEL_0A03710 ^@ http://purl.uniprot.org/uniprot/G8ZM59 ^@ Subunit ^@ The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. http://togogenome.org/gene/4950:TDEL_0B03520 ^@ http://purl.uniprot.org/uniprot/G8ZPD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Membrane http://togogenome.org/gene/4950:TDEL_0A02320 ^@ http://purl.uniprot.org/uniprot/G8ZLS0 ^@ Function|||Similarity ^@ Belongs to the glucose-6-phosphate 1-epimerase family.|||Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P). http://togogenome.org/gene/4950:TDEL_0G02470 ^@ http://purl.uniprot.org/uniprot/G8ZYY9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.|||Belongs to the SNF2/RAD54 helicase family.|||Component of the INO80 chromatin-remodeling complex.|||Nucleus|||The DBINO region is involved in binding to DNA. http://togogenome.org/gene/4950:TDEL_0C00530 ^@ http://purl.uniprot.org/uniprot/G8ZR00 ^@ Function|||Similarity ^@ Belongs to the phage and mitochondrial RNA polymerase family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/4950:TDEL_0C05620 ^@ http://purl.uniprot.org/uniprot/G8ZSF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase PH family.|||nucleolus http://togogenome.org/gene/4950:TDEL_0B07590 ^@ http://purl.uniprot.org/uniprot/G8ZQJ4 ^@ Similarity|||Subunit ^@ Belongs to the AlaDH/PNT family.|||Monomer. http://togogenome.org/gene/4950:TDEL_0B02770 ^@ http://purl.uniprot.org/uniprot/G8ZP62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Belongs to the NDUFAF7 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0A07690 ^@ http://purl.uniprot.org/uniprot/G8ZNA7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS19 family. http://togogenome.org/gene/4950:TDEL_0E05390 ^@ http://purl.uniprot.org/uniprot/G8ZVY8 ^@ Similarity ^@ Belongs to the U2 small nuclear ribonucleoprotein A family. http://togogenome.org/gene/4950:TDEL_0D02870 ^@ http://purl.uniprot.org/uniprot/G8ZTC7 ^@ Similarity ^@ Belongs to the CWC22 family. http://togogenome.org/gene/4950:TDEL_0C06720 ^@ http://purl.uniprot.org/uniprot/G8ZQS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/4950:TDEL_0B00460 ^@ http://purl.uniprot.org/uniprot/G8ZNI1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EROs family.|||Endoplasmic reticulum membrane|||May function both as a monomer and a homodimer. http://togogenome.org/gene/4950:TDEL_0B01650 ^@ http://purl.uniprot.org/uniprot/G8ZNV0 ^@ Similarity ^@ Belongs to the glycosyltransferase 34 family. http://togogenome.org/gene/4950:TDEL_0G05010 ^@ http://purl.uniprot.org/uniprot/G8ZYA1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0A03120 ^@ http://purl.uniprot.org/uniprot/G8ZM00 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/4950:TDEL_0H04180 ^@ http://purl.uniprot.org/uniprot/G9A083 ^@ Cofactor|||Function ^@ Accepts electrons from ETF and reduces ubiquinone.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/4950:TDEL_0B03940 ^@ http://purl.uniprot.org/uniprot/G8ZPH9 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/4950:TDEL_0D03380 ^@ http://purl.uniprot.org/uniprot/G8ZTH8 ^@ Similarity|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Homodimer. http://togogenome.org/gene/4950:TDEL_0B05950 ^@ http://purl.uniprot.org/uniprot/G8ZQ30 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/4950:TDEL_0B01430 ^@ http://purl.uniprot.org/uniprot/G8ZNS8 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/4950:TDEL_0D04630 ^@ http://purl.uniprot.org/uniprot/G8ZTV3 ^@ Function|||Similarity ^@ ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.|||Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. http://togogenome.org/gene/4950:TDEL_0B05520 ^@ http://purl.uniprot.org/uniprot/G8ZPY7 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/4950:TDEL_0A02350 ^@ http://purl.uniprot.org/uniprot/G8ZLS3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Mitochondrion|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.|||nucleolus|||nucleoplasm http://togogenome.org/gene/4950:TDEL_0F03440 ^@ http://purl.uniprot.org/uniprot/G8ZX11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Membrane http://togogenome.org/gene/4950:TDEL_0F04140 ^@ http://purl.uniprot.org/uniprot/G8ZX81 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Binds 2 Zn(2+) ions per subunit.|||Cytoplasm|||Homodimer.|||In the 2nd section; belongs to the EPSP synthase family.|||In the 2nd section; belongs to the type-I 3-dehydroquinase family.|||In the 3rd section; belongs to the shikimate kinase family.|||In the 4th section; belongs to the type-I 3-dehydroquinase family.|||In the C-terminal section; belongs to the shikimate dehydrogenase family.|||In the N-terminal section; belongs to the dehydroquinate synthase family.|||In the N-terminal section; belongs to the shikimate kinase family.|||In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. http://togogenome.org/gene/4950:TDEL_0C04290 ^@ http://purl.uniprot.org/uniprot/G8ZS26 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS13 family. http://togogenome.org/gene/4950:TDEL_0A04840 ^@ http://purl.uniprot.org/uniprot/G8ZMH2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/4950:TDEL_0H00610 ^@ http://purl.uniprot.org/uniprot/G8ZZ76 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/4950:TDEL_0F01790 ^@ http://purl.uniprot.org/uniprot/G8ZWJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-Z subfamily.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0A02810 ^@ http://purl.uniprot.org/uniprot/G8ZLW9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/4950:TDEL_0A02770 ^@ http://purl.uniprot.org/uniprot/G8ZLW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingosine N-acyltransferase family.|||Membrane http://togogenome.org/gene/4950:TDEL_0B03820 ^@ http://purl.uniprot.org/uniprot/G8ZPG7 ^@ Similarity ^@ Belongs to the EFR3 family. http://togogenome.org/gene/4950:TDEL_0H03300 ^@ http://purl.uniprot.org/uniprot/G8ZZZ5 ^@ Function|||Similarity ^@ Belongs to the peptidase T1A family.|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. http://togogenome.org/gene/4950:TDEL_0H02230 ^@ http://purl.uniprot.org/uniprot/G8ZZN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/4950:TDEL_0G01440 ^@ http://purl.uniprot.org/uniprot/G8ZYN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KXD1 family.|||Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.|||Endosome http://togogenome.org/gene/4950:TDEL_0G03880 ^@ http://purl.uniprot.org/uniprot/G8ZXY8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS30 family. http://togogenome.org/gene/4950:TDEL_0C01190 ^@ http://purl.uniprot.org/uniprot/G8ZR66 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAT1 family.|||Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.|||Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0E04070 ^@ http://purl.uniprot.org/uniprot/G8ZVK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF/MAK21 family.|||Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.|||nucleolus http://togogenome.org/gene/4950:TDEL_0G04070 ^@ http://purl.uniprot.org/uniprot/G8ZY07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HIT family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0G03400 ^@ http://purl.uniprot.org/uniprot/G8ZXU0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/4950:TDEL_0E03450 ^@ http://purl.uniprot.org/uniprot/G8ZVE4 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/4950:TDEL_0C04280 ^@ http://purl.uniprot.org/uniprot/G8ZS25 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/4950:TDEL_0G03510 ^@ http://purl.uniprot.org/uniprot/G8ZXV1 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. http://togogenome.org/gene/4950:TDEL_0B07030 ^@ http://purl.uniprot.org/uniprot/G8ZQD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin GLFG family.|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/4950:TDEL_0A00180 ^@ http://purl.uniprot.org/uniprot/G8ZL56 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/4950:TDEL_0F05470 ^@ http://purl.uniprot.org/uniprot/G8ZXL4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0A07490 ^@ http://purl.uniprot.org/uniprot/G8ZN87 ^@ Similarity ^@ Belongs to the pyridoxine kinase family. http://togogenome.org/gene/4950:TDEL_0A01620 ^@ http://purl.uniprot.org/uniprot/G8ZLK0 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/4950:TDEL_0B06390 ^@ http://purl.uniprot.org/uniprot/G8ZQ74 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS10 family. http://togogenome.org/gene/4950:TDEL_0E03190 ^@ http://purl.uniprot.org/uniprot/G8ZVB8 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0C00720 ^@ http://purl.uniprot.org/uniprot/G8ZR19 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI inositol-deacylase family.|||Endoplasmic reticulum membrane|||Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.|||Membrane http://togogenome.org/gene/4950:TDEL_0B00590 ^@ http://purl.uniprot.org/uniprot/G8ZNJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF8 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G04460 ^@ http://purl.uniprot.org/uniprot/G8ZY46 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/4950:TDEL_0G00850 ^@ http://purl.uniprot.org/uniprot/G8ZYH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Membrane http://togogenome.org/gene/4950:TDEL_0B01400 ^@ http://purl.uniprot.org/uniprot/G8ZNS5 ^@ Function|||Similarity ^@ Belongs to the catalase family.|||Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. http://togogenome.org/gene/4950:TDEL_0G02220 ^@ http://purl.uniprot.org/uniprot/G8ZYW4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP25 family.|||Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.|||DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.|||nucleolus http://togogenome.org/gene/4950:TDEL_0F05330 ^@ http://purl.uniprot.org/uniprot/G8ZXK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DASH complex SPC19 family.|||Nucleus|||kinetochore http://togogenome.org/gene/4950:TDEL_0F04470 ^@ http://purl.uniprot.org/uniprot/G8ZXB4 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/4950:TDEL_0D00200 ^@ http://purl.uniprot.org/uniprot/G8ZSL0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0E04810 ^@ http://purl.uniprot.org/uniprot/G8ZVT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0B07220 ^@ http://purl.uniprot.org/uniprot/G8ZQF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D03070 ^@ http://purl.uniprot.org/uniprot/G8ZTE7 ^@ Similarity ^@ Belongs to the cytidylyltransferase family. http://togogenome.org/gene/4950:TDEL_0G03250 ^@ http://purl.uniprot.org/uniprot/G8ZXS5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0C03050 ^@ http://purl.uniprot.org/uniprot/G8ZRQ2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. http://togogenome.org/gene/4950:TDEL_0B07150 ^@ http://purl.uniprot.org/uniprot/G8ZQF0 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/4950:TDEL_0A07140 ^@ http://purl.uniprot.org/uniprot/G8ZN52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG2 family.|||Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.|||Endoplasmic reticulum membrane http://togogenome.org/gene/4950:TDEL_0A06350 ^@ http://purl.uniprot.org/uniprot/G8ZMX3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Clp1 family. Clp1 subfamily.|||Belongs to the Clp1 family. NOL9/GRC3 subfamily.|||Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation. http://togogenome.org/gene/4950:TDEL_0A03680 ^@ http://purl.uniprot.org/uniprot/G8ZM56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B02810 ^@ http://purl.uniprot.org/uniprot/G8ZP66 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/4950:TDEL_0D02120 ^@ http://purl.uniprot.org/uniprot/G8ZT52 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/4950:TDEL_0H03200 ^@ http://purl.uniprot.org/uniprot/G8ZZY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM21 family.|||Involved in mitochondrial migration along actin filaments.|||actin patch http://togogenome.org/gene/4950:TDEL_0B02990 ^@ http://purl.uniprot.org/uniprot/G8ZP84 ^@ Function|||Similarity ^@ Belongs to the GPI family.|||In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. http://togogenome.org/gene/4950:TDEL_0G04320 ^@ http://purl.uniprot.org/uniprot/G8ZY32 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MDM12 family.|||Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.|||Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane http://togogenome.org/gene/4950:TDEL_0C02540 ^@ http://purl.uniprot.org/uniprot/G8ZRK1 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/4950:TDEL_0B03210 ^@ http://purl.uniprot.org/uniprot/G8ZPA6 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/4950:TDEL_0E02890 ^@ http://purl.uniprot.org/uniprot/G8ZV88 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily. http://togogenome.org/gene/4950:TDEL_0B02610 ^@ http://purl.uniprot.org/uniprot/G8ZP46 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/4950:TDEL_0B01760 ^@ http://purl.uniprot.org/uniprot/G8ZNW1 ^@ Function|||Similarity ^@ Belongs to the flavokinase family.|||Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme. http://togogenome.org/gene/4950:TDEL_0G04930 ^@ http://purl.uniprot.org/uniprot/G8ZY93 ^@ Similarity ^@ Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family. http://togogenome.org/gene/4950:TDEL_0A04730 ^@ http://purl.uniprot.org/uniprot/G8ZMG1 ^@ Similarity ^@ Belongs to the GroES chaperonin family. http://togogenome.org/gene/4950:TDEL_0G04050 ^@ http://purl.uniprot.org/uniprot/G8ZY05 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0E05210 ^@ http://purl.uniprot.org/uniprot/G8ZVX0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL12 family. http://togogenome.org/gene/4950:TDEL_0G04190 ^@ http://purl.uniprot.org/uniprot/G8ZY19 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/4950:TDEL_0H03880 ^@ http://purl.uniprot.org/uniprot/G9A053 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/4950:TDEL_0A00310 ^@ http://purl.uniprot.org/uniprot/G8ZL69 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/4950:TDEL_0G00300 ^@ http://purl.uniprot.org/uniprot/G8ZYC2 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. http://togogenome.org/gene/4950:TDEL_0F05610 ^@ http://purl.uniprot.org/uniprot/G8ZXM8 ^@ Similarity ^@ Belongs to the histidine acid phosphatase family. http://togogenome.org/gene/4950:TDEL_0A02560 ^@ http://purl.uniprot.org/uniprot/G8ZLU4 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0B03810 ^@ http://purl.uniprot.org/uniprot/G8ZPG6 ^@ Similarity ^@ Belongs to the CEF1 family. http://togogenome.org/gene/4950:TDEL_0G00730 ^@ http://purl.uniprot.org/uniprot/G8ZYG5 ^@ Similarity ^@ Belongs to the WD repeat RAPTOR family. http://togogenome.org/gene/4950:TDEL_0H04290 ^@ http://purl.uniprot.org/uniprot/G9A094 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit B family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. http://togogenome.org/gene/4950:TDEL_0H02260 ^@ http://purl.uniprot.org/uniprot/G8ZZP1 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/4950:TDEL_0D00630 ^@ http://purl.uniprot.org/uniprot/G8ZSQ3 ^@ Similarity ^@ Belongs to the allantoicase family. http://togogenome.org/gene/4950:TDEL_0E04340 ^@ http://purl.uniprot.org/uniprot/G8ZVN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0H01010 ^@ http://purl.uniprot.org/uniprot/G8ZZB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0C04500 ^@ http://purl.uniprot.org/uniprot/G8ZS47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MET18/MMS19 family.|||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G00210 ^@ http://purl.uniprot.org/uniprot/G8ZYB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0B00800 ^@ http://purl.uniprot.org/uniprot/G8ZNL5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0G01730 ^@ http://purl.uniprot.org/uniprot/G8ZYR5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat PRP19 family.|||Homotetramer.|||Nucleus|||Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. http://togogenome.org/gene/4950:TDEL_0A03980 ^@ http://purl.uniprot.org/uniprot/G8ZM86 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the kynurenine formamidase family.|||Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.|||Homodimer.|||The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage. http://togogenome.org/gene/4950:TDEL_0C02180 ^@ http://purl.uniprot.org/uniprot/G8ZRG5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG9 family.|||Cytoplasmic vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.|||Preautophagosomal structure membrane http://togogenome.org/gene/4950:TDEL_0A03470 ^@ http://purl.uniprot.org/uniprot/G8ZM35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM31/MDM32 family.|||Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0C03350 ^@ http://purl.uniprot.org/uniprot/G8ZRT2 ^@ Similarity ^@ Belongs to the phospholipid scramblase family. http://togogenome.org/gene/4950:TDEL_0H01830 ^@ http://purl.uniprot.org/uniprot/G8ZZJ8 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0C02850 ^@ http://purl.uniprot.org/uniprot/G8ZRN2 ^@ Similarity ^@ Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. http://togogenome.org/gene/4950:TDEL_0D02650 ^@ http://purl.uniprot.org/uniprot/G8ZTA5 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/4950:TDEL_0G02560 ^@ http://purl.uniprot.org/uniprot/G8ZYZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase PH family.|||nucleolus http://togogenome.org/gene/4950:TDEL_0D02760 ^@ http://purl.uniprot.org/uniprot/G8ZTB6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM21 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0D06150 ^@ http://purl.uniprot.org/uniprot/G8ZUA5 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/4950:TDEL_0A06670 ^@ http://purl.uniprot.org/uniprot/G8ZN05 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D02240 ^@ http://purl.uniprot.org/uniprot/G8ZT64 ^@ Similarity ^@ Belongs to the SH3YL1 family. http://togogenome.org/gene/4950:TDEL_0F00700 ^@ http://purl.uniprot.org/uniprot/G8ZW87 ^@ Similarity ^@ Belongs to the APC1 family. http://togogenome.org/gene/4950:TDEL_0E00630 ^@ http://purl.uniprot.org/uniprot/G8ZUL2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0H01120 ^@ http://purl.uniprot.org/uniprot/G8ZZC7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.|||Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.|||Cytoplasm|||P-body http://togogenome.org/gene/4950:TDEL_0H03550 ^@ http://purl.uniprot.org/uniprot/G9A020 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS19 family. http://togogenome.org/gene/4950:TDEL_0D01670 ^@ http://purl.uniprot.org/uniprot/G8ZT07 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS2/PSF2 family.|||Component of the GINS complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D06410 ^@ http://purl.uniprot.org/uniprot/G8ZUD1 ^@ Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase class-II family. http://togogenome.org/gene/4950:TDEL_0F05380 ^@ http://purl.uniprot.org/uniprot/G8ZXK5 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/4950:TDEL_0H00220 ^@ http://purl.uniprot.org/uniprot/G8ZZ37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid/polyamine transporter 2 family.|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0H04060 ^@ http://purl.uniprot.org/uniprot/G9A071 ^@ Similarity|||Subunit ^@ Belongs to the pyruvate kinase family.|||Homotetramer. http://togogenome.org/gene/4950:TDEL_0H01250 ^@ http://purl.uniprot.org/uniprot/G8ZZE0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ASF1 family.|||Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.|||Interacts with histone H3.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D04100 ^@ http://purl.uniprot.org/uniprot/G8ZTQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C01780 ^@ http://purl.uniprot.org/uniprot/G8ZRC5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Endoplasmic reticulum membrane|||Membrane|||Necessary for protein translocation in the endoplasmic reticulum. http://togogenome.org/gene/4950:TDEL_0C05780 ^@ http://purl.uniprot.org/uniprot/G8ZSH5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pex2/pex10/pex12 family.|||Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/4950:TDEL_0B05330 ^@ http://purl.uniprot.org/uniprot/G8ZPW8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0C06910 ^@ http://purl.uniprot.org/uniprot/G8ZQU3 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/4950:TDEL_0F03560 ^@ http://purl.uniprot.org/uniprot/G8ZX23 ^@ Subcellular Location Annotation ^@ Nucleus membrane http://togogenome.org/gene/4950:TDEL_0A04000 ^@ http://purl.uniprot.org/uniprot/G8ZM88 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/4950:TDEL_0E03550 ^@ http://purl.uniprot.org/uniprot/G8ZVF4 ^@ Function|||Similarity ^@ Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.|||Belongs to the proteasome subunit S2 family. http://togogenome.org/gene/4950:TDEL_0C02590 ^@ http://purl.uniprot.org/uniprot/G8ZRK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D05920 ^@ http://purl.uniprot.org/uniprot/G8ZU82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. http://togogenome.org/gene/4950:TDEL_0D00420 ^@ http://purl.uniprot.org/uniprot/G8ZSN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HIR3 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A01250 ^@ http://purl.uniprot.org/uniprot/G8ZLG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad17/RAD24 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B01600 ^@ http://purl.uniprot.org/uniprot/G8ZNU5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/4950:TDEL_0G02350 ^@ http://purl.uniprot.org/uniprot/G8ZYX7 ^@ Similarity ^@ Belongs to the PPC synthetase family. http://togogenome.org/gene/4950:TDEL_0B01110 ^@ http://purl.uniprot.org/uniprot/G8ZNP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus http://togogenome.org/gene/4950:TDEL_0F03520 ^@ http://purl.uniprot.org/uniprot/G8ZX19 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/4950:TDEL_0C03300 ^@ http://purl.uniprot.org/uniprot/G8ZRS7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/4950:TDEL_0D05000 ^@ http://purl.uniprot.org/uniprot/G8ZTZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BMT2 family.|||S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.|||nucleolus http://togogenome.org/gene/4950:TDEL_0H01680 ^@ http://purl.uniprot.org/uniprot/G8ZZI3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.|||Binds 1 FMN per subunit.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0G00770 ^@ http://purl.uniprot.org/uniprot/G8ZYG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0C00320 ^@ http://purl.uniprot.org/uniprot/G8ZQX9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/4950:TDEL_0G01800 ^@ http://purl.uniprot.org/uniprot/G8ZYS2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GOSR1 family.|||Component of several multiprotein Golgi SNARE complexes.|||Golgi apparatus membrane|||Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.|||Membrane http://togogenome.org/gene/4950:TDEL_0B03720 ^@ http://purl.uniprot.org/uniprot/G8ZPF7 ^@ Similarity ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily. http://togogenome.org/gene/4950:TDEL_0D01350 ^@ http://purl.uniprot.org/uniprot/G8ZSX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family.|||Cell membrane|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0A03730 ^@ http://purl.uniprot.org/uniprot/G8ZM61 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/4950:TDEL_0H01840 ^@ http://purl.uniprot.org/uniprot/G8ZZJ9 ^@ Subcellular Location Annotation ^@ Membrane|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0G01370 ^@ http://purl.uniprot.org/uniprot/G8ZYM9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0C03840 ^@ http://purl.uniprot.org/uniprot/G8ZRY1 ^@ Similarity|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Octamer of two non-identical subunits IDH1 and IDH2. http://togogenome.org/gene/4950:TDEL_0E01120 ^@ http://purl.uniprot.org/uniprot/G8ZUR1 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/4950:TDEL_0C00610 ^@ http://purl.uniprot.org/uniprot/G8ZR08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E02610 ^@ http://purl.uniprot.org/uniprot/G8ZV60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND3 (condensin subunit 3) family.|||Chromosome http://togogenome.org/gene/4950:TDEL_0F03320 ^@ http://purl.uniprot.org/uniprot/G8ZWZ9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VMA21 family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. http://togogenome.org/gene/4950:TDEL_0G03100 ^@ http://purl.uniprot.org/uniprot/G8ZXR0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit I family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0B04530 ^@ http://purl.uniprot.org/uniprot/G8ZPN8 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/4950:TDEL_0A05030 ^@ http://purl.uniprot.org/uniprot/G8ZMJ1 ^@ Similarity ^@ Belongs to the SEN54 family. http://togogenome.org/gene/4950:TDEL_0B04320 ^@ http://purl.uniprot.org/uniprot/G8ZPL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0H01400 ^@ http://purl.uniprot.org/uniprot/G8ZZF5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DPH1/DPH2 family. DPH2 subfamily.|||Cytoplasm|||Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit. http://togogenome.org/gene/4950:TDEL_0E00380 ^@ http://purl.uniprot.org/uniprot/G8ZUI7 ^@ Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. http://togogenome.org/gene/4950:TDEL_0E01800 ^@ http://purl.uniprot.org/uniprot/G8ZUX9 ^@ Function|||Similarity ^@ Belongs to the WD repeat EIF2A family.|||Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. http://togogenome.org/gene/4950:TDEL_0F00190 ^@ http://purl.uniprot.org/uniprot/G8ZW36 ^@ Subcellular Location Annotation ^@ Cell surface http://togogenome.org/gene/4950:TDEL_0G00360 ^@ http://purl.uniprot.org/uniprot/G8ZYC8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 72 family.|||Cell membrane|||Membrane|||Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. http://togogenome.org/gene/4950:TDEL_0D06280 ^@ http://purl.uniprot.org/uniprot/G8ZUB8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NFYA/HAP2 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.|||Heterotrimer.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D03850 ^@ http://purl.uniprot.org/uniprot/G8ZTM5 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/4950:TDEL_0A03400 ^@ http://purl.uniprot.org/uniprot/G8ZM28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C03600 ^@ http://purl.uniprot.org/uniprot/G8ZRV7 ^@ Function|||Similarity ^@ Belongs to the VPS35 family.|||Plays a role in vesicular protein sorting. http://togogenome.org/gene/4950:TDEL_0F04750 ^@ http://purl.uniprot.org/uniprot/G8ZXE2 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/4950:TDEL_0D02150 ^@ http://purl.uniprot.org/uniprot/G8ZT55 ^@ Function|||Similarity ^@ Belongs to the LplA family.|||Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. http://togogenome.org/gene/4950:TDEL_0G04390 ^@ http://purl.uniprot.org/uniprot/G8ZY39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B04390 ^@ http://purl.uniprot.org/uniprot/G8ZPM4 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/4950:TDEL_0B05230 ^@ http://purl.uniprot.org/uniprot/G8ZPV8 ^@ Similarity ^@ Belongs to the TRAPP small subunits family. BET3 subfamily. http://togogenome.org/gene/4950:TDEL_0D05780 ^@ http://purl.uniprot.org/uniprot/G8ZU68 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/4950:TDEL_0A00490 ^@ http://purl.uniprot.org/uniprot/G8ZL87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP11 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0E02730 ^@ http://purl.uniprot.org/uniprot/G8ZV72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DASH complex DAD4 family.|||Nucleus|||kinetochore|||spindle http://togogenome.org/gene/4950:TDEL_0E03470 ^@ http://purl.uniprot.org/uniprot/G8ZVE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELOF1 family.|||Nucleus|||Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. http://togogenome.org/gene/4950:TDEL_0B00570 ^@ http://purl.uniprot.org/uniprot/G8ZNJ2 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/4950:TDEL_0C03110 ^@ http://purl.uniprot.org/uniprot/G8ZRQ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EAF6 family.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.|||Component of the NuA4 histone acetyltransferase complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0H00330 ^@ http://purl.uniprot.org/uniprot/G8ZZ48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGU family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0G01230 ^@ http://purl.uniprot.org/uniprot/G8ZYL5 ^@ Similarity ^@ Belongs to the KNR4/SMI1 family. http://togogenome.org/gene/4950:TDEL_0A05650 ^@ http://purl.uniprot.org/uniprot/G8ZMQ3 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/4950:TDEL_0A06590 ^@ http://purl.uniprot.org/uniprot/G8ZMZ7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCA family.|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.|||cytoskeleton http://togogenome.org/gene/4950:TDEL_0A04080 ^@ http://purl.uniprot.org/uniprot/G8ZM96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGS family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0D04200 ^@ http://purl.uniprot.org/uniprot/G8ZTR0 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/4950:TDEL_0B03970 ^@ http://purl.uniprot.org/uniprot/G8ZPI2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HDDC2 family.|||Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).|||Homodimer. http://togogenome.org/gene/4950:TDEL_0A04230 ^@ http://purl.uniprot.org/uniprot/G8ZMB1 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/4950:TDEL_0C04090 ^@ http://purl.uniprot.org/uniprot/G8ZS06 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/4950:TDEL_0D03610 ^@ http://purl.uniprot.org/uniprot/G8ZTK1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0G00900 ^@ http://purl.uniprot.org/uniprot/G8ZYI2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG7 family.|||Cytoplasm|||E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.|||Homodimer.|||Preautophagosomal structure http://togogenome.org/gene/4950:TDEL_0C01990 ^@ http://purl.uniprot.org/uniprot/G8ZRE6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0E04440 ^@ http://purl.uniprot.org/uniprot/G8ZVP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the squalene monooxygenase family.|||Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/4950:TDEL_0G02050 ^@ http://purl.uniprot.org/uniprot/G8ZYU7 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/4950:TDEL_0G04900 ^@ http://purl.uniprot.org/uniprot/G8ZY90 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/4950:TDEL_0B03650 ^@ http://purl.uniprot.org/uniprot/G8ZPF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MRE11/RAD32 family.|||Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E00170 ^@ http://purl.uniprot.org/uniprot/G8ZUG6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homotetramer.|||Secreted http://togogenome.org/gene/4950:TDEL_0C03230 ^@ http://purl.uniprot.org/uniprot/G8ZRS0 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/4950:TDEL_0F03430 ^@ http://purl.uniprot.org/uniprot/G8ZX10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DASH complex DAM1 family.|||Nucleus|||kinetochore|||spindle http://togogenome.org/gene/4950:TDEL_0B05700 ^@ http://purl.uniprot.org/uniprot/G8ZQ05 ^@ Similarity ^@ Belongs to the SWM2 family. http://togogenome.org/gene/4950:TDEL_0C02900 ^@ http://purl.uniprot.org/uniprot/G8ZRN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A00680 ^@ http://purl.uniprot.org/uniprot/G8ZLA6 ^@ Cofactor ^@ Divalent metal ions. Mg(2+) is the most effective. http://togogenome.org/gene/4950:TDEL_0C03690 ^@ http://purl.uniprot.org/uniprot/G8ZRW6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.|||Endoplasmic reticulum membrane|||Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/4950:TDEL_0C06170 ^@ http://purl.uniprot.org/uniprot/G8ZQL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0G04330 ^@ http://purl.uniprot.org/uniprot/G8ZY33 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/4950:TDEL_0B01630 ^@ http://purl.uniprot.org/uniprot/G8ZNU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPF family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G00250 ^@ http://purl.uniprot.org/uniprot/G8ZYB7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/4950:TDEL_0B00260 ^@ http://purl.uniprot.org/uniprot/G8ZNG1 ^@ Similarity ^@ Belongs to the phytoene/squalene synthase family. http://togogenome.org/gene/4950:TDEL_0D04780 ^@ http://purl.uniprot.org/uniprot/G8ZTW8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrion-specific ribosomal protein mS37 family.|||Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.|||Component of the mitochondrial small ribosomal subunit.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0F05410 ^@ http://purl.uniprot.org/uniprot/G8ZXK8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/4950:TDEL_0B00400 ^@ http://purl.uniprot.org/uniprot/G8ZNH5 ^@ Function|||Similarity ^@ Belongs to the peptidase T1A family.|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. http://togogenome.org/gene/4950:TDEL_0G02920 ^@ http://purl.uniprot.org/uniprot/G8ZXP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/4950:TDEL_0C02360 ^@ http://purl.uniprot.org/uniprot/G8ZRI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC31 family.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane http://togogenome.org/gene/4950:TDEL_0B02540 ^@ http://purl.uniprot.org/uniprot/G8ZP39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0D00850 ^@ http://purl.uniprot.org/uniprot/G8ZSS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSRP1 family.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Nucleus http://togogenome.org/gene/4950:TDEL_0H01640 ^@ http://purl.uniprot.org/uniprot/G8ZZH9 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/4950:TDEL_0A03480 ^@ http://purl.uniprot.org/uniprot/G8ZM36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPP2 family.|||Involved in spliceosome maturation and the first step of pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D01270 ^@ http://purl.uniprot.org/uniprot/G8ZSW7 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/4950:TDEL_0A05060 ^@ http://purl.uniprot.org/uniprot/G8ZMJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC16 family.|||Endoplasmic reticulum membrane|||Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.|||Membrane http://togogenome.org/gene/4950:TDEL_0F03150 ^@ http://purl.uniprot.org/uniprot/G8ZWY2 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/4950:TDEL_0C05140 ^@ http://purl.uniprot.org/uniprot/G8ZSB1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family.|||Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.|||Homodimer. http://togogenome.org/gene/4950:TDEL_0F05100 ^@ http://purl.uniprot.org/uniprot/G8ZXH7 ^@ Similarity ^@ In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family. http://togogenome.org/gene/4950:TDEL_0A03940 ^@ http://purl.uniprot.org/uniprot/G8ZM82 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/4950:TDEL_0G01640 ^@ http://purl.uniprot.org/uniprot/G8ZYQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0B05450 ^@ http://purl.uniprot.org/uniprot/G8ZPY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUA5 family.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/4950:TDEL_0D04090 ^@ http://purl.uniprot.org/uniprot/G8ZTP9 ^@ Similarity ^@ Belongs to the ATPase epsilon chain family. http://togogenome.org/gene/4950:TDEL_0C06740 ^@ http://purl.uniprot.org/uniprot/G8ZQS6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC1 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0A04090 ^@ http://purl.uniprot.org/uniprot/G8ZM97 ^@ Similarity ^@ Belongs to the TAF11 family. http://togogenome.org/gene/4950:TDEL_0F01590 ^@ http://purl.uniprot.org/uniprot/G8ZWH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Bud neck http://togogenome.org/gene/4950:TDEL_0A04330 ^@ http://purl.uniprot.org/uniprot/G8ZMC1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endopolyphosphatase PPN1 family.|||Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.|||Membrane|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0A04960 ^@ http://purl.uniprot.org/uniprot/G8ZMI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Membrane http://togogenome.org/gene/4950:TDEL_0B03890 ^@ http://purl.uniprot.org/uniprot/G8ZPH4 ^@ Similarity ^@ Belongs to the bystin family. http://togogenome.org/gene/4950:TDEL_0F04010 ^@ http://purl.uniprot.org/uniprot/G8ZX68 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. http://togogenome.org/gene/4950:TDEL_0A01660 ^@ http://purl.uniprot.org/uniprot/G8ZLK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DASH complex DAD3 family.|||Nucleus|||kinetochore|||spindle http://togogenome.org/gene/4950:TDEL_0G03260 ^@ http://purl.uniprot.org/uniprot/G8ZXS6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0C05530 ^@ http://purl.uniprot.org/uniprot/G8ZSF0 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL5 family.|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. http://togogenome.org/gene/4950:TDEL_0B05680 ^@ http://purl.uniprot.org/uniprot/G8ZQ03 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. http://togogenome.org/gene/4950:TDEL_0F00310 ^@ http://purl.uniprot.org/uniprot/G8ZW48 ^@ Similarity ^@ Belongs to the glycosyltransferase 32 family. http://togogenome.org/gene/4950:TDEL_0A00170 ^@ http://purl.uniprot.org/uniprot/G8ZL55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A04570 ^@ http://purl.uniprot.org/uniprot/G8ZME5 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/4950:TDEL_0B06150 ^@ http://purl.uniprot.org/uniprot/G8ZQ50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0B05830 ^@ http://purl.uniprot.org/uniprot/G8ZQ18 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/4950:TDEL_0F02680 ^@ http://purl.uniprot.org/uniprot/G8ZWT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HOP2 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A06340 ^@ http://purl.uniprot.org/uniprot/G8ZMX2 ^@ Similarity ^@ Belongs to the APC5 family. http://togogenome.org/gene/4950:TDEL_0H03830 ^@ http://purl.uniprot.org/uniprot/G9A048 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/4950:TDEL_0D02530 ^@ http://purl.uniprot.org/uniprot/G8ZT93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0D04890 ^@ http://purl.uniprot.org/uniprot/G8ZTX9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0F03180 ^@ http://purl.uniprot.org/uniprot/G8ZWY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/4950:TDEL_0G02870 ^@ http://purl.uniprot.org/uniprot/G8ZXN7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/4950:TDEL_0F02630 ^@ http://purl.uniprot.org/uniprot/G8ZWT0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/4950:TDEL_0A07480 ^@ http://purl.uniprot.org/uniprot/G8ZN86 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC12 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/4950:TDEL_0B03490 ^@ http://purl.uniprot.org/uniprot/G8ZPD4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS11 family.|||Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0F01510 ^@ http://purl.uniprot.org/uniprot/G8ZWG8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.|||Belongs to the DNA polymerase alpha subunit B family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D05580 ^@ http://purl.uniprot.org/uniprot/G8ZU48 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYF2 family.|||Involved in pre-mRNA splicing.|||May be part of a spliceosome complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G00840 ^@ http://purl.uniprot.org/uniprot/G8ZYH6 ^@ Similarity ^@ Belongs to the FMO family. http://togogenome.org/gene/4950:TDEL_0B04980 ^@ http://purl.uniprot.org/uniprot/G8ZPT3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.|||Interacts with TAN1.|||RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.|||nucleolus http://togogenome.org/gene/4950:TDEL_0H00880 ^@ http://purl.uniprot.org/uniprot/G8ZZA3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0F00490 ^@ http://purl.uniprot.org/uniprot/G8ZW66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/4950:TDEL_0E04450 ^@ http://purl.uniprot.org/uniprot/G8ZVP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRN7/TAF1B family.|||nucleolus http://togogenome.org/gene/4950:TDEL_0C00630 ^@ http://purl.uniprot.org/uniprot/G8ZR10 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/4950:TDEL_0A05790 ^@ http://purl.uniprot.org/uniprot/G8ZMR7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0B00250 ^@ http://purl.uniprot.org/uniprot/G8ZNG0 ^@ Similarity ^@ Belongs to the PTH family. http://togogenome.org/gene/4950:TDEL_0B01660 ^@ http://purl.uniprot.org/uniprot/G8ZNV1 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/4950:TDEL_0B03570 ^@ http://purl.uniprot.org/uniprot/G8ZPE2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/4950:TDEL_0G02240 ^@ http://purl.uniprot.org/uniprot/G8ZYW6 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/4950:TDEL_0B06570 ^@ http://purl.uniprot.org/uniprot/G8ZQ92 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/4950:TDEL_0B01340 ^@ http://purl.uniprot.org/uniprot/G8ZNR9 ^@ Similarity ^@ Belongs to the CWC21 family. http://togogenome.org/gene/4950:TDEL_0H02920 ^@ http://purl.uniprot.org/uniprot/G8ZZV7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.|||Belongs to the URM1 family.|||C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0G02500 ^@ http://purl.uniprot.org/uniprot/G8ZYZ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup84/Nup107 family.|||Functions as a component of the nuclear pore complex (NPC).|||Nucleus membrane|||Part of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/4950:TDEL_0G04290 ^@ http://purl.uniprot.org/uniprot/G8ZY29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF4 family.|||Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.|||Nucleus http://togogenome.org/gene/4950:TDEL_0H03050 ^@ http://purl.uniprot.org/uniprot/G8ZZX0 ^@ Similarity ^@ Belongs to the synaptojanin family.|||In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. http://togogenome.org/gene/4950:TDEL_0A05360 ^@ http://purl.uniprot.org/uniprot/G8ZMM4 ^@ Subcellular Location Annotation ^@ Peroxisome membrane http://togogenome.org/gene/4950:TDEL_0A02540 ^@ http://purl.uniprot.org/uniprot/G8ZLU2 ^@ Similarity ^@ Belongs to the peptidase M18 family. http://togogenome.org/gene/4950:TDEL_0C02080 ^@ http://purl.uniprot.org/uniprot/G8ZRF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Membrane|||nuclear pore complex http://togogenome.org/gene/4950:TDEL_0H03870 ^@ http://purl.uniprot.org/uniprot/G9A052 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-A family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0A06740 ^@ http://purl.uniprot.org/uniprot/G8ZN12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G03980 ^@ http://purl.uniprot.org/uniprot/G8ZXZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G02990 ^@ http://purl.uniprot.org/uniprot/G8ZXP9 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/4950:TDEL_0C03120 ^@ http://purl.uniprot.org/uniprot/G8ZRQ9 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/4950:TDEL_0C01980 ^@ http://purl.uniprot.org/uniprot/G8ZRE5 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. http://togogenome.org/gene/4950:TDEL_0E05220 ^@ http://purl.uniprot.org/uniprot/G8ZVX1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/4950:TDEL_0F01190 ^@ http://purl.uniprot.org/uniprot/G8ZWD6 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/4950:TDEL_0C02380 ^@ http://purl.uniprot.org/uniprot/G8ZRI5 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/4950:TDEL_0B02720 ^@ http://purl.uniprot.org/uniprot/G8ZP57 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/4950:TDEL_0B05320 ^@ http://purl.uniprot.org/uniprot/G8ZPW7 ^@ Similarity ^@ Belongs to the PET191 family. http://togogenome.org/gene/4950:TDEL_0C07030 ^@ http://purl.uniprot.org/uniprot/G8ZQV5 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/4950:TDEL_0E03110 ^@ http://purl.uniprot.org/uniprot/G8ZVB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AATF family.|||nucleolus http://togogenome.org/gene/4950:TDEL_0H03120 ^@ http://purl.uniprot.org/uniprot/G8ZZX7 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/4950:TDEL_0E00430 ^@ http://purl.uniprot.org/uniprot/G8ZUJ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 16 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C04760 ^@ http://purl.uniprot.org/uniprot/G8ZS73 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/4950:TDEL_0E00400 ^@ http://purl.uniprot.org/uniprot/G8ZUI9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C1 family.|||Cytoplasm|||Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.|||Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.|||Mitochondrion|||The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities. http://togogenome.org/gene/4950:TDEL_0H01600 ^@ http://purl.uniprot.org/uniprot/G8ZZH5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0C05050 ^@ http://purl.uniprot.org/uniprot/G8ZSA2 ^@ Similarity ^@ Belongs to the spermidine/spermine synthase family. http://togogenome.org/gene/4950:TDEL_0D03620 ^@ http://purl.uniprot.org/uniprot/G8ZTK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal/bacterial/fungal opsin family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A02300 ^@ http://purl.uniprot.org/uniprot/G8ZLR8 ^@ Similarity ^@ Belongs to the MUB1/samB family. http://togogenome.org/gene/4950:TDEL_0F04640 ^@ http://purl.uniprot.org/uniprot/G8ZXD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAC3 family.|||Nucleus envelope http://togogenome.org/gene/4950:TDEL_0B05060 ^@ http://purl.uniprot.org/uniprot/G8ZPU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||microtubule organizing center http://togogenome.org/gene/4950:TDEL_0F05620 ^@ http://purl.uniprot.org/uniprot/G8ZXM9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/4950:TDEL_0D00240 ^@ http://purl.uniprot.org/uniprot/G8ZSL4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0F02760 ^@ http://purl.uniprot.org/uniprot/G8ZWU3 ^@ Similarity ^@ Belongs to the glycosyltransferase 32 family. http://togogenome.org/gene/4950:TDEL_0B02200 ^@ http://purl.uniprot.org/uniprot/G8ZP05 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G03810 ^@ http://purl.uniprot.org/uniprot/G8ZXY1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ran family.|||GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.|||Nucleus http://togogenome.org/gene/4950:TDEL_0H04350 ^@ http://purl.uniprot.org/uniprot/G9A0A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transient receptor potential (TRP) ion channel family.|||Membrane http://togogenome.org/gene/4950:TDEL_0F03190 ^@ http://purl.uniprot.org/uniprot/G8ZWY6 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0G01420 ^@ http://purl.uniprot.org/uniprot/G8ZYN4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/4950:TDEL_0A06170 ^@ http://purl.uniprot.org/uniprot/G8ZMV5 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/4950:TDEL_0E04380 ^@ http://purl.uniprot.org/uniprot/G8ZVN7 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/4950:TDEL_0E04420 ^@ http://purl.uniprot.org/uniprot/G8ZVP1 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/4950:TDEL_0H00820 ^@ http://purl.uniprot.org/uniprot/G8ZZ97 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFIIE beta subunit family.|||Nucleus|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.|||Tetramer of two alpha and two beta chains. http://togogenome.org/gene/4950:TDEL_0D03990 ^@ http://purl.uniprot.org/uniprot/G8ZTN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCO1/2 family.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0C04700 ^@ http://purl.uniprot.org/uniprot/G8ZS67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Mitochondrion matrix http://togogenome.org/gene/4950:TDEL_0A05110 ^@ http://purl.uniprot.org/uniprot/G8ZMJ9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Cytoplasm|||Maintains high levels of reduced glutathione in the cytosol. http://togogenome.org/gene/4950:TDEL_0F03940 ^@ http://purl.uniprot.org/uniprot/G8ZX61 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/4950:TDEL_0A04870 ^@ http://purl.uniprot.org/uniprot/G8ZMH5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/4950:TDEL_0G01260 ^@ http://purl.uniprot.org/uniprot/G8ZYL8 ^@ Subcellular Location Annotation ^@ Peroxisome membrane http://togogenome.org/gene/4950:TDEL_0C02530 ^@ http://purl.uniprot.org/uniprot/G8ZRK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ISY1 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0H00770 ^@ http://purl.uniprot.org/uniprot/G8ZZ92 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/4950:TDEL_0E00820 ^@ http://purl.uniprot.org/uniprot/G8ZUN1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/4950:TDEL_0H01620 ^@ http://purl.uniprot.org/uniprot/G8ZZH7 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/4950:TDEL_0G04580 ^@ http://purl.uniprot.org/uniprot/G8ZY58 ^@ Similarity ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. http://togogenome.org/gene/4950:TDEL_0B07060 ^@ http://purl.uniprot.org/uniprot/G8ZQE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat BOP1/ERB1 family.|||Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.|||Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/4950:TDEL_0A07600 ^@ http://purl.uniprot.org/uniprot/G8ZN98 ^@ Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily. http://togogenome.org/gene/4950:TDEL_0F04410 ^@ http://purl.uniprot.org/uniprot/G8ZXA8 ^@ Function ^@ Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo. http://togogenome.org/gene/4950:TDEL_0D06420 ^@ http://purl.uniprot.org/uniprot/G8ZUD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Non-catalytic component of the proteasome.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C01560 ^@ http://purl.uniprot.org/uniprot/G8ZRA3 ^@ Function|||Similarity ^@ 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).|||Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/4950:TDEL_0B05930 ^@ http://purl.uniprot.org/uniprot/G8ZQ28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D05770 ^@ http://purl.uniprot.org/uniprot/G8ZU67 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C05890 ^@ http://purl.uniprot.org/uniprot/G8ZSI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.|||nucleolus http://togogenome.org/gene/4950:TDEL_0C02270 ^@ http://purl.uniprot.org/uniprot/G8ZRH4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0E05120 ^@ http://purl.uniprot.org/uniprot/G8ZVW1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0B06780 ^@ http://purl.uniprot.org/uniprot/G8ZQB3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/4950:TDEL_0H01050 ^@ http://purl.uniprot.org/uniprot/G8ZZC0 ^@ Similarity ^@ In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily. http://togogenome.org/gene/4950:TDEL_0C03220 ^@ http://purl.uniprot.org/uniprot/G8ZRR9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC2 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. http://togogenome.org/gene/4950:TDEL_0B03240 ^@ http://purl.uniprot.org/uniprot/G8ZPA9 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0C02830 ^@ http://purl.uniprot.org/uniprot/G8ZRN0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/4950:TDEL_0H02110 ^@ http://purl.uniprot.org/uniprot/G8ZZM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SYG1 (TC 2.A.94) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0C01800 ^@ http://purl.uniprot.org/uniprot/G8ZRC7 ^@ Similarity ^@ Belongs to the serine/threonine dehydratase family. http://togogenome.org/gene/4950:TDEL_0B00700 ^@ http://purl.uniprot.org/uniprot/G8ZNK5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer. http://togogenome.org/gene/4950:TDEL_0G03850 ^@ http://purl.uniprot.org/uniprot/G8ZXY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. LepA subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Mitochondrion inner membrane|||Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. http://togogenome.org/gene/4950:TDEL_0F02360 ^@ http://purl.uniprot.org/uniprot/G8ZWQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. http://togogenome.org/gene/4950:TDEL_0F05510 ^@ http://purl.uniprot.org/uniprot/G8ZXL8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0A07760 ^@ http://purl.uniprot.org/uniprot/G8ZNB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0F03110 ^@ http://purl.uniprot.org/uniprot/G8ZWX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP31 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A07990 ^@ http://purl.uniprot.org/uniprot/G8ZND7 ^@ Function|||Similarity ^@ Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/4950:TDEL_0F03050 ^@ http://purl.uniprot.org/uniprot/G8ZWX2 ^@ Similarity ^@ Belongs to the CDC6/cdc18 family. http://togogenome.org/gene/4950:TDEL_0G02110 ^@ http://purl.uniprot.org/uniprot/G8ZYV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D01860 ^@ http://purl.uniprot.org/uniprot/G8ZT26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.|||Endoplasmic reticulum membrane|||Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.|||Membrane http://togogenome.org/gene/4950:TDEL_0F03010 ^@ http://purl.uniprot.org/uniprot/G8ZWW8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/4950:TDEL_0F03700 ^@ http://purl.uniprot.org/uniprot/G8ZX37 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/4950:TDEL_0F00460 ^@ http://purl.uniprot.org/uniprot/G8ZW63 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. http://togogenome.org/gene/4950:TDEL_0A03990 ^@ http://purl.uniprot.org/uniprot/G8ZM87 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit G family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. http://togogenome.org/gene/4950:TDEL_0G02000 ^@ http://purl.uniprot.org/uniprot/G8ZYU2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/4950:TDEL_0G04260 ^@ http://purl.uniprot.org/uniprot/G8ZY26 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/4950:TDEL_0B00760 ^@ http://purl.uniprot.org/uniprot/G8ZNL1 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/4950:TDEL_0E05170 ^@ http://purl.uniprot.org/uniprot/G8ZVW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B00170 ^@ http://purl.uniprot.org/uniprot/G8ZNF2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0A00630 ^@ http://purl.uniprot.org/uniprot/G8ZLA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D05350 ^@ http://purl.uniprot.org/uniprot/G8ZU25 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.|||Belongs to the complex I LYR family. MZM1 subfamily.|||Interacts with RIP1.|||Mitochondrion matrix http://togogenome.org/gene/4950:TDEL_0F05160 ^@ http://purl.uniprot.org/uniprot/G8ZXI3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/4950:TDEL_0D04710 ^@ http://purl.uniprot.org/uniprot/G8ZTW1 ^@ Similarity ^@ Belongs to the sirtuin family. Class I subfamily. http://togogenome.org/gene/4950:TDEL_0B03600 ^@ http://purl.uniprot.org/uniprot/G8ZPE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL53 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0F01300 ^@ http://purl.uniprot.org/uniprot/G8ZWE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A00200 ^@ http://purl.uniprot.org/uniprot/G8ZL58 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/4950:TDEL_0B02910 ^@ http://purl.uniprot.org/uniprot/G8ZP76 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily. http://togogenome.org/gene/4950:TDEL_0G04950 ^@ http://purl.uniprot.org/uniprot/G8ZY95 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0C01000 ^@ http://purl.uniprot.org/uniprot/G8ZR47 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/4950:TDEL_0E03140 ^@ http://purl.uniprot.org/uniprot/G8ZVB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL67 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0B02110 ^@ http://purl.uniprot.org/uniprot/G8ZNZ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTPA-type PPIase family.|||Cytoplasm|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/4950:TDEL_0F02600 ^@ http://purl.uniprot.org/uniprot/G8ZWS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CGR1 family.|||Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.|||nucleolus http://togogenome.org/gene/4950:TDEL_0G04620 ^@ http://purl.uniprot.org/uniprot/G8ZY62 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0G01160 ^@ http://purl.uniprot.org/uniprot/G8ZYK8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0E05340 ^@ http://purl.uniprot.org/uniprot/G8ZVY3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NIP7 family.|||Interacts with pre-ribosome complex.|||Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.|||nucleolus http://togogenome.org/gene/4950:TDEL_0D01320 ^@ http://purl.uniprot.org/uniprot/G8ZSX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DASH complex SPC34 family.|||Nucleus|||kinetochore|||spindle http://togogenome.org/gene/4950:TDEL_0B02780 ^@ http://purl.uniprot.org/uniprot/G8ZP63 ^@ Function|||Similarity ^@ Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.|||Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. http://togogenome.org/gene/4950:TDEL_0B04600 ^@ http://purl.uniprot.org/uniprot/G8ZPP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 6A family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0D01160 ^@ http://purl.uniprot.org/uniprot/G8ZSV6 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0B00120 ^@ http://purl.uniprot.org/uniprot/G8ZNE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.|||Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.|||Membrane http://togogenome.org/gene/4950:TDEL_0G02790 ^@ http://purl.uniprot.org/uniprot/G8ZZ21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/4950:TDEL_0D03980 ^@ http://purl.uniprot.org/uniprot/G8ZTN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.|||Cytoplasm|||Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.|||Monomer. http://togogenome.org/gene/4950:TDEL_0F01120 ^@ http://purl.uniprot.org/uniprot/G8ZWC9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0C00290 ^@ http://purl.uniprot.org/uniprot/G8ZQX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BOS1 family.|||Golgi apparatus membrane|||Membrane|||SNARE required for protein transport between the ER and the Golgi complex. http://togogenome.org/gene/4950:TDEL_0B05280 ^@ http://purl.uniprot.org/uniprot/G8ZPW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0F04210 ^@ http://purl.uniprot.org/uniprot/G8ZX88 ^@ Function|||Similarity ^@ Belongs to the tRNA-intron endonuclease family.|||Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. http://togogenome.org/gene/4950:TDEL_0H02740 ^@ http://purl.uniprot.org/uniprot/G8ZZT9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dUTPase family.|||Homotrimer.|||Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/4950:TDEL_0D02450 ^@ http://purl.uniprot.org/uniprot/G8ZT85 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/4950:TDEL_0A06030 ^@ http://purl.uniprot.org/uniprot/G8ZMU1 ^@ Similarity ^@ Belongs to the dihydrofolate reductase family. http://togogenome.org/gene/4950:TDEL_0F02390 ^@ http://purl.uniprot.org/uniprot/G8ZWQ6 ^@ Function|||Similarity ^@ Belongs to the aconitase/IPM isomerase family.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. http://togogenome.org/gene/4950:TDEL_0H00650 ^@ http://purl.uniprot.org/uniprot/G8ZZ80 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/4950:TDEL_0H01810 ^@ http://purl.uniprot.org/uniprot/G8ZZJ6 ^@ Similarity ^@ Belongs to the YOS1 family. http://togogenome.org/gene/4950:TDEL_0F02140 ^@ http://purl.uniprot.org/uniprot/G8ZWN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF5 family.|||Nucleus|||Part of the chromatin structure-remodeling complex (RSC) which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is essential for mitotic growth and required for cell cycle progression. http://togogenome.org/gene/4950:TDEL_0F00890 ^@ http://purl.uniprot.org/uniprot/G8ZWA6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/4950:TDEL_0C03580 ^@ http://purl.uniprot.org/uniprot/G8ZRV5 ^@ Similarity ^@ Belongs to the myo-inositol 1-phosphate synthase family. http://togogenome.org/gene/4950:TDEL_0H01900 ^@ http://purl.uniprot.org/uniprot/G8ZZK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.|||Cytoplasm|||S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport. http://togogenome.org/gene/4950:TDEL_0E01950 ^@ http://purl.uniprot.org/uniprot/G8ZUZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF1 family.|||nucleolus http://togogenome.org/gene/4950:TDEL_0B02340 ^@ http://purl.uniprot.org/uniprot/G8ZP19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0F03290 ^@ http://purl.uniprot.org/uniprot/G8ZWZ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Required for proper protein synthesis within the mitochondrion.|||Belongs to the GatF family.|||Mitochondrion inner membrane|||Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits. http://togogenome.org/gene/4950:TDEL_0A07820 ^@ http://purl.uniprot.org/uniprot/G8ZNC0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0C03550 ^@ http://purl.uniprot.org/uniprot/G8ZRV2 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/4950:TDEL_0H01890 ^@ http://purl.uniprot.org/uniprot/G8ZZK4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIS1 family.|||Has a role in mitochondrial fission.|||Membrane|||Mitochondrion outer membrane|||The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission. http://togogenome.org/gene/4950:TDEL_0A04220 ^@ http://purl.uniprot.org/uniprot/G8ZMB0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 13 family.|||Component of the SRB8-11 complex, which itself associates with the Mediator complex.|||Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B03540 ^@ http://purl.uniprot.org/uniprot/G8ZPD9 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner. http://togogenome.org/gene/4950:TDEL_0E03560 ^@ http://purl.uniprot.org/uniprot/G8ZVF5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''. http://togogenome.org/gene/4950:TDEL_0A05510 ^@ http://purl.uniprot.org/uniprot/G8ZMN9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0C03370 ^@ http://purl.uniprot.org/uniprot/G8ZRT4 ^@ Similarity ^@ Belongs to the VPS25 family. http://togogenome.org/gene/4950:TDEL_0H03180 ^@ http://purl.uniprot.org/uniprot/G8ZZY3 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/4950:TDEL_0C05650 ^@ http://purl.uniprot.org/uniprot/G8ZSG2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0G02540 ^@ http://purl.uniprot.org/uniprot/G8ZYZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Endosome membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0D04340 ^@ http://purl.uniprot.org/uniprot/G8ZTS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYSTM1 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0B04270 ^@ http://purl.uniprot.org/uniprot/G8ZPL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX15/CtaA family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A04650 ^@ http://purl.uniprot.org/uniprot/G8ZMF3 ^@ Similarity ^@ Belongs to the VPS29 family. http://togogenome.org/gene/4950:TDEL_0B03430 ^@ http://purl.uniprot.org/uniprot/G8ZPC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CybS family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0A04290 ^@ http://purl.uniprot.org/uniprot/G8ZMB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP6 family.|||nucleolus http://togogenome.org/gene/4950:TDEL_0E04740 ^@ http://purl.uniprot.org/uniprot/G8ZVS3 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/4950:TDEL_0G01310 ^@ http://purl.uniprot.org/uniprot/G8ZYM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.|||Cell membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0D01840 ^@ http://purl.uniprot.org/uniprot/G8ZT24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0B04740 ^@ http://purl.uniprot.org/uniprot/G8ZPQ9 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/4950:TDEL_0C02400 ^@ http://purl.uniprot.org/uniprot/G8ZRI7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/4950:TDEL_0H01380 ^@ http://purl.uniprot.org/uniprot/G8ZZF3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0B02000 ^@ http://purl.uniprot.org/uniprot/G8ZNY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RSA3 family.|||Required for efficient biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/4950:TDEL_0C06400 ^@ http://purl.uniprot.org/uniprot/G8ZQP2 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/4950:TDEL_0G00130 ^@ http://purl.uniprot.org/uniprot/G8ZYA5 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/4950:TDEL_0A01220 ^@ http://purl.uniprot.org/uniprot/G8ZLG0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/4950:TDEL_0E02590 ^@ http://purl.uniprot.org/uniprot/G8ZV58 ^@ Similarity ^@ Belongs to the SWI5/SAE3 family. http://togogenome.org/gene/4950:TDEL_0E01840 ^@ http://purl.uniprot.org/uniprot/G8ZUY3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0B03230 ^@ http://purl.uniprot.org/uniprot/G8ZPA8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0A07100 ^@ http://purl.uniprot.org/uniprot/G8ZN48 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0C07000 ^@ http://purl.uniprot.org/uniprot/G8ZQV2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0H01510 ^@ http://purl.uniprot.org/uniprot/G8ZZG6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family. http://togogenome.org/gene/4950:TDEL_0D03500 ^@ http://purl.uniprot.org/uniprot/G8ZTJ0 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/4950:TDEL_0B04720 ^@ http://purl.uniprot.org/uniprot/G8ZPQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0A05210 ^@ http://purl.uniprot.org/uniprot/G8ZMK9 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/4950:TDEL_0A04880 ^@ http://purl.uniprot.org/uniprot/G8ZMH6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0E03250 ^@ http://purl.uniprot.org/uniprot/G8ZVC4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Expected to bind 2 Fe(2+) ions per subunit.|||Membrane|||Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. http://togogenome.org/gene/4950:TDEL_0F00420 ^@ http://purl.uniprot.org/uniprot/G8ZW59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus|||tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. http://togogenome.org/gene/4950:TDEL_0D01020 ^@ http://purl.uniprot.org/uniprot/G8ZSU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIF1/spd1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0E04410 ^@ http://purl.uniprot.org/uniprot/G8ZVP0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/4950:TDEL_0A02680 ^@ http://purl.uniprot.org/uniprot/G8ZLV6 ^@ Similarity ^@ Belongs to the CWC16 family. http://togogenome.org/gene/4950:TDEL_0E02540 ^@ http://purl.uniprot.org/uniprot/G8ZV53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the C1D family.|||Nucleus|||Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites. http://togogenome.org/gene/4950:TDEL_0D01820 ^@ http://purl.uniprot.org/uniprot/G8ZT22 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL17 family. http://togogenome.org/gene/4950:TDEL_0A01420 ^@ http://purl.uniprot.org/uniprot/G8ZLI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecE/SEC61-gamma family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0H01660 ^@ http://purl.uniprot.org/uniprot/G8ZZI1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COPE family.|||Cytoplasm|||Membrane|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/4950:TDEL_0H03530 ^@ http://purl.uniprot.org/uniprot/G9A018 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/4950:TDEL_0A05990 ^@ http://purl.uniprot.org/uniprot/G8ZMT7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/4950:TDEL_0F00630 ^@ http://purl.uniprot.org/uniprot/G8ZW80 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0A07280 ^@ http://purl.uniprot.org/uniprot/G8ZN66 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/4950:TDEL_0C01050 ^@ http://purl.uniprot.org/uniprot/G8ZR52 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes small subunit family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. http://togogenome.org/gene/4950:TDEL_0C04740 ^@ http://purl.uniprot.org/uniprot/G8ZS71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PCNA family.|||Nucleus|||This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. http://togogenome.org/gene/4950:TDEL_0E03420 ^@ http://purl.uniprot.org/uniprot/G8ZVE1 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/4950:TDEL_0B04110 ^@ http://purl.uniprot.org/uniprot/G8ZPJ6 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/4950:TDEL_0B00130 ^@ http://purl.uniprot.org/uniprot/G8ZNE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D04650 ^@ http://purl.uniprot.org/uniprot/G8ZTV5 ^@ Function|||Similarity ^@ Belongs to the inositol monophosphatase superfamily.|||Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. http://togogenome.org/gene/4950:TDEL_0B05910 ^@ http://purl.uniprot.org/uniprot/G8ZQ26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-II family.|||Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0A00270 ^@ http://purl.uniprot.org/uniprot/G8ZL65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C00400 ^@ http://purl.uniprot.org/uniprot/G8ZQY7 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/4950:TDEL_0D03920 ^@ http://purl.uniprot.org/uniprot/G8ZTN2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/4950:TDEL_0C01660 ^@ http://purl.uniprot.org/uniprot/G8ZRB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM11 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0F02840 ^@ http://purl.uniprot.org/uniprot/G8ZWV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A06690 ^@ http://purl.uniprot.org/uniprot/G8ZN07 ^@ Function|||Similarity ^@ Belongs to the misato family.|||Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance. http://togogenome.org/gene/4950:TDEL_0A06850 ^@ http://purl.uniprot.org/uniprot/G8ZN23 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0C00450 ^@ http://purl.uniprot.org/uniprot/G8ZQZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D01330 ^@ http://purl.uniprot.org/uniprot/G8ZSX3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0A06640 ^@ http://purl.uniprot.org/uniprot/G8ZN02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/4950:TDEL_0H02500 ^@ http://purl.uniprot.org/uniprot/G8ZZR5 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/4950:TDEL_0D05360 ^@ http://purl.uniprot.org/uniprot/G8ZU26 ^@ Function|||Similarity ^@ Belongs to the KptA/TPT1 family.|||Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate. http://togogenome.org/gene/4950:TDEL_0H01410 ^@ http://purl.uniprot.org/uniprot/G8ZZF6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the calcineurin regulatory subunit family.|||Composed of a catalytic subunit (A) and a regulatory subunit (B).|||Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. http://togogenome.org/gene/4950:TDEL_0A02440 ^@ http://purl.uniprot.org/uniprot/G8ZLT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLD2 family.|||Has a role in the initiation of DNA replication. Required at S-phase checkpoint.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C05600 ^@ http://purl.uniprot.org/uniprot/G8ZSF7 ^@ Function|||Similarity ^@ Belongs to the catalase family.|||Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. http://togogenome.org/gene/4950:TDEL_0C05010 ^@ http://purl.uniprot.org/uniprot/G8ZS98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM3 family.|||Membrane raft http://togogenome.org/gene/4950:TDEL_0E00550 ^@ http://purl.uniprot.org/uniprot/G8ZUK4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. http://togogenome.org/gene/4950:TDEL_0E02070 ^@ http://purl.uniprot.org/uniprot/G8ZV06 ^@ Function|||Similarity ^@ Belongs to the EAF1 family.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. http://togogenome.org/gene/4950:TDEL_0H02440 ^@ http://purl.uniprot.org/uniprot/G8ZZQ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0C06000 ^@ http://purl.uniprot.org/uniprot/G8ZSJ7 ^@ Similarity ^@ Belongs to the putative lipase ROG1 family. http://togogenome.org/gene/4950:TDEL_0D02680 ^@ http://purl.uniprot.org/uniprot/G8ZTA8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0H02220 ^@ http://purl.uniprot.org/uniprot/G8ZZN7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS18 family. http://togogenome.org/gene/4950:TDEL_0A03970 ^@ http://purl.uniprot.org/uniprot/G8ZM85 ^@ Similarity ^@ Belongs to the proteasome subunit S11 family. http://togogenome.org/gene/4950:TDEL_0G04060 ^@ http://purl.uniprot.org/uniprot/G8ZY06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 4 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0F01670 ^@ http://purl.uniprot.org/uniprot/G8ZWI4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0G02300 ^@ http://purl.uniprot.org/uniprot/G8ZYX2 ^@ Similarity ^@ Belongs to the glycosyltransferase 15 family. http://togogenome.org/gene/4950:TDEL_0B01330 ^@ http://purl.uniprot.org/uniprot/G8ZNR8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ODC antizyme family.|||Interacts with ODC and thereby sterically blocks ODC homodimerization.|||Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. http://togogenome.org/gene/4950:TDEL_0B01050 ^@ http://purl.uniprot.org/uniprot/G8ZNP0 ^@ Similarity ^@ Belongs to the SUN family. http://togogenome.org/gene/4950:TDEL_0E01000 ^@ http://purl.uniprot.org/uniprot/G8ZUP9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family. http://togogenome.org/gene/4950:TDEL_0F01270 ^@ http://purl.uniprot.org/uniprot/G8ZWE4 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. http://togogenome.org/gene/4950:TDEL_0C01180 ^@ http://purl.uniprot.org/uniprot/G8ZR65 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SNF8 family.|||Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II). http://togogenome.org/gene/4950:TDEL_0E01430 ^@ http://purl.uniprot.org/uniprot/G8ZUU2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0B04960 ^@ http://purl.uniprot.org/uniprot/G8ZPT1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0C05730 ^@ http://purl.uniprot.org/uniprot/G8ZSH0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0F00470 ^@ http://purl.uniprot.org/uniprot/G8ZW64 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/4950:TDEL_0G02430 ^@ http://purl.uniprot.org/uniprot/G8ZYY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.|||Membrane|||Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0E04530 ^@ http://purl.uniprot.org/uniprot/G8ZVQ2 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/4950:TDEL_0C04470 ^@ http://purl.uniprot.org/uniprot/G8ZS44 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0C03100 ^@ http://purl.uniprot.org/uniprot/G8ZRQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM24 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0B03500 ^@ http://purl.uniprot.org/uniprot/G8ZPD5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS10 family. http://togogenome.org/gene/4950:TDEL_0A07710 ^@ http://purl.uniprot.org/uniprot/G8ZNA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 12 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D01910 ^@ http://purl.uniprot.org/uniprot/G8ZT31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the battenin family.|||Membrane|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0G04470 ^@ http://purl.uniprot.org/uniprot/G8ZY47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0F01310 ^@ http://purl.uniprot.org/uniprot/G8ZWE8 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/4950:TDEL_0H01300 ^@ http://purl.uniprot.org/uniprot/G8ZZE5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/4950:TDEL_0H01540 ^@ http://purl.uniprot.org/uniprot/G8ZZG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.|||Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.|||Membrane|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0D01850 ^@ http://purl.uniprot.org/uniprot/G8ZT25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the REI1 family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0H03910 ^@ http://purl.uniprot.org/uniprot/G9A056 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SNW family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E02290 ^@ http://purl.uniprot.org/uniprot/G8ZV28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A05020 ^@ http://purl.uniprot.org/uniprot/G8ZMJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane http://togogenome.org/gene/4950:TDEL_0D04310 ^@ http://purl.uniprot.org/uniprot/G8ZTS1 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/4950:TDEL_0B01060 ^@ http://purl.uniprot.org/uniprot/G8ZNP1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0A03920 ^@ http://purl.uniprot.org/uniprot/G8ZM80 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0C05380 ^@ http://purl.uniprot.org/uniprot/G8ZSD5 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. ATM subfamily. http://togogenome.org/gene/4950:TDEL_0A04630 ^@ http://purl.uniprot.org/uniprot/G8ZMF1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL27 family. http://togogenome.org/gene/4950:TDEL_0D04810 ^@ http://purl.uniprot.org/uniprot/G8ZTX1 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/4950:TDEL_0H03480 ^@ http://purl.uniprot.org/uniprot/G9A013 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SWC3 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B07280 ^@ http://purl.uniprot.org/uniprot/G8ZQG3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex. http://togogenome.org/gene/4950:TDEL_0B06610 ^@ http://purl.uniprot.org/uniprot/G8ZQ96 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. http://togogenome.org/gene/4950:TDEL_0A04520 ^@ http://purl.uniprot.org/uniprot/G8ZME0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0B00420 ^@ http://purl.uniprot.org/uniprot/G8ZNH7 ^@ Similarity ^@ Belongs to the prefoldin subunit alpha family. http://togogenome.org/gene/4950:TDEL_0C01330 ^@ http://purl.uniprot.org/uniprot/G8ZR80 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0D01470 ^@ http://purl.uniprot.org/uniprot/G8ZSY7 ^@ Similarity ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. http://togogenome.org/gene/4950:TDEL_0A00430 ^@ http://purl.uniprot.org/uniprot/G8ZL81 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0B04890 ^@ http://purl.uniprot.org/uniprot/G8ZPS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC2 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0D01490 ^@ http://purl.uniprot.org/uniprot/G8ZSY9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EXO70 family.|||Bud|||Bud neck|||Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst. http://togogenome.org/gene/4950:TDEL_0F03670 ^@ http://purl.uniprot.org/uniprot/G8ZX34 ^@ Similarity ^@ Belongs to the Mo25 family. http://togogenome.org/gene/4950:TDEL_0E05560 ^@ http://purl.uniprot.org/uniprot/G8ZW05 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/4950:TDEL_0C04410 ^@ http://purl.uniprot.org/uniprot/G8ZS38 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RNase HII family. Eukaryotic subfamily.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/4950:TDEL_0C06230 ^@ http://purl.uniprot.org/uniprot/G8ZQM5 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/4950:TDEL_0B07300 ^@ http://purl.uniprot.org/uniprot/G8ZQG5 ^@ Similarity ^@ Belongs to the SURF6 family. http://togogenome.org/gene/4950:TDEL_0F04790 ^@ http://purl.uniprot.org/uniprot/G8ZXE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat TRM82 family.|||Nucleus|||Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. http://togogenome.org/gene/4950:TDEL_0H03170 ^@ http://purl.uniprot.org/uniprot/G8ZZY2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.|||Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.|||Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C02610 ^@ http://purl.uniprot.org/uniprot/G8ZRK8 ^@ Function|||PTM|||Similarity ^@ Belongs to the eIF-5A family.|||Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group. http://togogenome.org/gene/4950:TDEL_0D02910 ^@ http://purl.uniprot.org/uniprot/G8ZTD1 ^@ Cofactor|||Function|||Similarity ^@ Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.|||Belongs to the tRNA(His) guanylyltransferase family.|||Binds 2 magnesium ions per subunit. http://togogenome.org/gene/4950:TDEL_0F03850 ^@ http://purl.uniprot.org/uniprot/G8ZX52 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/4950:TDEL_0E02370 ^@ http://purl.uniprot.org/uniprot/G8ZV36 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. MetX family. http://togogenome.org/gene/4950:TDEL_0A04810 ^@ http://purl.uniprot.org/uniprot/G8ZMG9 ^@ Subcellular Location Annotation ^@ Peroxisome membrane http://togogenome.org/gene/4950:TDEL_0F02990 ^@ http://purl.uniprot.org/uniprot/G8ZWW6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/4950:TDEL_0B05990 ^@ http://purl.uniprot.org/uniprot/G8ZQ34 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/4950:TDEL_0C06510 ^@ http://purl.uniprot.org/uniprot/G8ZQQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0G00160 ^@ http://purl.uniprot.org/uniprot/G8ZYA8 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/4950:TDEL_0D04480 ^@ http://purl.uniprot.org/uniprot/G8ZTT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OSBP family.|||Membrane http://togogenome.org/gene/4950:TDEL_0B04280 ^@ http://purl.uniprot.org/uniprot/G8ZPL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAPT1 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0B01030 ^@ http://purl.uniprot.org/uniprot/G8ZNN8 ^@ Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B family. http://togogenome.org/gene/4950:TDEL_0F03770 ^@ http://purl.uniprot.org/uniprot/G8ZX44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A06880 ^@ http://purl.uniprot.org/uniprot/G8ZN26 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/4950:TDEL_0B04830 ^@ http://purl.uniprot.org/uniprot/G8ZPR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G04550 ^@ http://purl.uniprot.org/uniprot/G8ZY55 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/4950:TDEL_0D00910 ^@ http://purl.uniprot.org/uniprot/G8ZST1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC1 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Nucleus|||ORC is composed of six subunits. http://togogenome.org/gene/4950:TDEL_0F00440 ^@ http://purl.uniprot.org/uniprot/G8ZW61 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/4950:TDEL_0A08030 ^@ http://purl.uniprot.org/uniprot/G8ZNE1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0E02820 ^@ http://purl.uniprot.org/uniprot/G8ZV81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP4 family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0B02300 ^@ http://purl.uniprot.org/uniprot/G8ZP15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WHI5/NRM1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0E03920 ^@ http://purl.uniprot.org/uniprot/G8ZVJ1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NMT1/THI5 family.|||Homodimer.|||Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. http://togogenome.org/gene/4950:TDEL_0A01950 ^@ http://purl.uniprot.org/uniprot/G8ZLN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Membrane http://togogenome.org/gene/4950:TDEL_0E02700 ^@ http://purl.uniprot.org/uniprot/G8ZV69 ^@ Similarity ^@ In the C-terminal section; belongs to the NAD synthetase family. http://togogenome.org/gene/4950:TDEL_0H00390 ^@ http://purl.uniprot.org/uniprot/G8ZZ54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase epsilon subunit B family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B05770 ^@ http://purl.uniprot.org/uniprot/G8ZQ12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G02160 ^@ http://purl.uniprot.org/uniprot/G8ZYV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. http://togogenome.org/gene/4950:TDEL_0G00440 ^@ http://purl.uniprot.org/uniprot/G8ZYD6 ^@ Cofactor|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/4950:TDEL_0A06150 ^@ http://purl.uniprot.org/uniprot/G8ZMV3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ A monovalent cation.|||Belongs to the folylpolyglutamate synthase family.|||Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Required for methionine synthesis and maintenance of intact mitochondrial DNA. Involved in telomere maintenance.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0C03070 ^@ http://purl.uniprot.org/uniprot/G8ZRQ4 ^@ Similarity ^@ Belongs to the MIX23 family. http://togogenome.org/gene/4950:TDEL_0E04370 ^@ http://purl.uniprot.org/uniprot/G8ZVN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0F03950 ^@ http://purl.uniprot.org/uniprot/G8ZX62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL1 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0A00590 ^@ http://purl.uniprot.org/uniprot/G8ZL97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0B04930 ^@ http://purl.uniprot.org/uniprot/G8ZPS8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/4950:TDEL_0H04470 ^@ http://purl.uniprot.org/uniprot/G9A0B2 ^@ Similarity|||Subunit ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Homohexamer. http://togogenome.org/gene/4950:TDEL_0A02080 ^@ http://purl.uniprot.org/uniprot/G8ZLP6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion.|||Mitochondrion matrix http://togogenome.org/gene/4950:TDEL_0E01060 ^@ http://purl.uniprot.org/uniprot/G8ZUQ5 ^@ Function|||Similarity ^@ Belongs to the dus family. Dus3 subfamily.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. http://togogenome.org/gene/4950:TDEL_0G04730 ^@ http://purl.uniprot.org/uniprot/G8ZY73 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/4950:TDEL_0C06890 ^@ http://purl.uniprot.org/uniprot/G8ZQU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGX family.|||Endoplasmic reticulum membrane|||Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14. http://togogenome.org/gene/4950:TDEL_0C01870 ^@ http://purl.uniprot.org/uniprot/G8ZRD4 ^@ Cofactor|||Similarity ^@ Belongs to the glutamate synthase family.|||Binds 1 [3Fe-4S] cluster. http://togogenome.org/gene/4950:TDEL_0G01690 ^@ http://purl.uniprot.org/uniprot/G8ZYR1 ^@ Similarity ^@ Belongs to the Clp1 family. NOL9/GRC3 subfamily. http://togogenome.org/gene/4950:TDEL_0G04230 ^@ http://purl.uniprot.org/uniprot/G8ZY23 ^@ Similarity ^@ Belongs to the chaperonin (HSP60) family. http://togogenome.org/gene/4950:TDEL_0E03460 ^@ http://purl.uniprot.org/uniprot/G8ZVE5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 5A family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0F00160 ^@ http://purl.uniprot.org/uniprot/G8ZW33 ^@ Similarity ^@ Belongs to the mannitol dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0C04540 ^@ http://purl.uniprot.org/uniprot/G8ZS51 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0B05000 ^@ http://purl.uniprot.org/uniprot/G8ZPT5 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/4950:TDEL_0D00180 ^@ http://purl.uniprot.org/uniprot/G8ZSK8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0D03020 ^@ http://purl.uniprot.org/uniprot/G8ZTE2 ^@ Function|||Similarity ^@ Belongs to the SNU71 family.|||Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway. http://togogenome.org/gene/4950:TDEL_0A03790 ^@ http://purl.uniprot.org/uniprot/G8ZM67 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0H01960 ^@ http://purl.uniprot.org/uniprot/G8ZZL1 ^@ Function|||Similarity ^@ Belongs to the RGI1 family.|||Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions. http://togogenome.org/gene/4950:TDEL_0G02750 ^@ http://purl.uniprot.org/uniprot/G8ZZ17 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/4950:TDEL_0C01270 ^@ http://purl.uniprot.org/uniprot/G8ZR74 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/4950:TDEL_0E03630 ^@ http://purl.uniprot.org/uniprot/G8ZVG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP receptor beta subunit family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0A06900 ^@ http://purl.uniprot.org/uniprot/G8ZN28 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvP family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/4950:TDEL_0C01210 ^@ http://purl.uniprot.org/uniprot/G8ZR68 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/4950:TDEL_0D01200 ^@ http://purl.uniprot.org/uniprot/G8ZSW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TIM16/PAM16 family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0D05280 ^@ http://purl.uniprot.org/uniprot/G8ZU18 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DHBP synthase family.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Homodimer. http://togogenome.org/gene/4950:TDEL_0B00980 ^@ http://purl.uniprot.org/uniprot/G8ZNN3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LTN1 family.|||Component of the ribosome quality control complex (RQC).|||E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.|||cytosol http://togogenome.org/gene/4950:TDEL_0B06960 ^@ http://purl.uniprot.org/uniprot/G8ZQD1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.|||Membrane http://togogenome.org/gene/4950:TDEL_0F02110 ^@ http://purl.uniprot.org/uniprot/G8ZWM8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0A02570 ^@ http://purl.uniprot.org/uniprot/G8ZLU5 ^@ Similarity ^@ Belongs to the peptidase A22B family. http://togogenome.org/gene/4950:TDEL_0C02920 ^@ http://purl.uniprot.org/uniprot/G8ZRN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aromatic-ring hydroxylase family. KMO subfamily.|||Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.|||Mitochondrion outer membrane http://togogenome.org/gene/4950:TDEL_0B06800 ^@ http://purl.uniprot.org/uniprot/G8ZQB5 ^@ Similarity ^@ Belongs to the TRIAP1/MDM35 family. http://togogenome.org/gene/4950:TDEL_0C05210 ^@ http://purl.uniprot.org/uniprot/G8ZSB8 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/4950:TDEL_0F03360 ^@ http://purl.uniprot.org/uniprot/G8ZX03 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/4950:TDEL_0C01890 ^@ http://purl.uniprot.org/uniprot/G8ZRD6 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/4950:TDEL_0E00900 ^@ http://purl.uniprot.org/uniprot/G8ZUN9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the fungal fatty acid synthetase subunit beta family.|||Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.|||[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta). http://togogenome.org/gene/4950:TDEL_0A02860 ^@ http://purl.uniprot.org/uniprot/G8ZLX4 ^@ Function|||Similarity ^@ Belongs to the APS kinase family.|||Catalyzes the synthesis of activated sulfate. http://togogenome.org/gene/4950:TDEL_0E02330 ^@ http://purl.uniprot.org/uniprot/G8ZV32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP23/FCF1 family. FCF1 subfamily.|||nucleolus http://togogenome.org/gene/4950:TDEL_0D04130 ^@ http://purl.uniprot.org/uniprot/G8ZTQ3 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/4950:TDEL_0B05460 ^@ http://purl.uniprot.org/uniprot/G8ZPY1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/4950:TDEL_0E01640 ^@ http://purl.uniprot.org/uniprot/G8ZUW3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT4 family.|||Nucleus|||The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.|||centromere http://togogenome.org/gene/4950:TDEL_0D03220 ^@ http://purl.uniprot.org/uniprot/G8ZTG2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit A family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. http://togogenome.org/gene/4950:TDEL_0B07180 ^@ http://purl.uniprot.org/uniprot/G8ZQF3 ^@ Similarity ^@ Belongs to the SEN15 family. http://togogenome.org/gene/4950:TDEL_0E05140 ^@ http://purl.uniprot.org/uniprot/G8ZVW3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/4950:TDEL_0B02630 ^@ http://purl.uniprot.org/uniprot/G8ZP48 ^@ Similarity ^@ Belongs to the putative lipase ROG1 family. http://togogenome.org/gene/4950:TDEL_0G03210 ^@ http://purl.uniprot.org/uniprot/G8ZXS1 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) per subunit. http://togogenome.org/gene/4950:TDEL_0E00790 ^@ http://purl.uniprot.org/uniprot/G8ZUM8 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/4950:TDEL_0F03810 ^@ http://purl.uniprot.org/uniprot/G8ZX48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0H04270 ^@ http://purl.uniprot.org/uniprot/G9A092 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/4950:TDEL_0E04240 ^@ http://purl.uniprot.org/uniprot/G8ZVM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/4950:TDEL_0A02710 ^@ http://purl.uniprot.org/uniprot/G8ZLV9 ^@ Similarity ^@ Belongs to the CENP-C/MIF2 family. http://togogenome.org/gene/4950:TDEL_0A06330 ^@ http://purl.uniprot.org/uniprot/G8ZMX1 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/4950:TDEL_0B04400 ^@ http://purl.uniprot.org/uniprot/G8ZPM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G00120 ^@ http://purl.uniprot.org/uniprot/G8ZYA4 ^@ Similarity ^@ Belongs to the PhyH family. http://togogenome.org/gene/4950:TDEL_0A05220 ^@ http://purl.uniprot.org/uniprot/G8ZML0 ^@ Similarity ^@ Belongs to the MGR2 family. http://togogenome.org/gene/4950:TDEL_0G03570 ^@ http://purl.uniprot.org/uniprot/G8ZXV7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG12 family.|||Forms a conjugate with ATG5.|||Membrane|||Preautophagosomal structure membrane|||Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. http://togogenome.org/gene/4950:TDEL_0B00270 ^@ http://purl.uniprot.org/uniprot/G8ZNG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0F01090 ^@ http://purl.uniprot.org/uniprot/G8ZWC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.|||nucleolus http://togogenome.org/gene/4950:TDEL_0D04570 ^@ http://purl.uniprot.org/uniprot/G8ZTU7 ^@ Function|||Similarity ^@ 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).|||Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/4950:TDEL_0G02260 ^@ http://purl.uniprot.org/uniprot/G8ZYW8 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/4950:TDEL_0H02390 ^@ http://purl.uniprot.org/uniprot/G8ZZQ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the F-actin-capping protein beta subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit.|||cytoskeleton http://togogenome.org/gene/4950:TDEL_0B02240 ^@ http://purl.uniprot.org/uniprot/G8ZP09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid/polyamine transporter 2 family.|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0A04670 ^@ http://purl.uniprot.org/uniprot/G8ZMF5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Part of the multisubunit TRAPP (transport protein particle) complex.|||Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.|||cis-Golgi network http://togogenome.org/gene/4950:TDEL_0D00750 ^@ http://purl.uniprot.org/uniprot/G8ZSR5 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily. http://togogenome.org/gene/4950:TDEL_0F00170 ^@ http://purl.uniprot.org/uniprot/G8ZW34 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D04830 ^@ http://purl.uniprot.org/uniprot/G8ZTX3 ^@ Similarity ^@ Belongs to the RENT3 family. http://togogenome.org/gene/4950:TDEL_0A07090 ^@ http://purl.uniprot.org/uniprot/G8ZN47 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS27 family.|||Component of the ESCRT-0 complex composed of HSE1 and VPS27.|||Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.|||Endosome membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0E05500 ^@ http://purl.uniprot.org/uniprot/G8ZVZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transient receptor potential (TRP) ion channel family.|||Membrane http://togogenome.org/gene/4950:TDEL_0E00750 ^@ http://purl.uniprot.org/uniprot/G8ZUM4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ERF4 family.|||Endoplasmic reticulum membrane|||Interacts with ERF2. http://togogenome.org/gene/4950:TDEL_0B04680 ^@ http://purl.uniprot.org/uniprot/G8ZPQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MND1 family.|||Nucleus|||Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. http://togogenome.org/gene/4950:TDEL_0G04650 ^@ http://purl.uniprot.org/uniprot/G8ZY65 ^@ Similarity ^@ Belongs to the eukaryotic ATPase epsilon family. http://togogenome.org/gene/4950:TDEL_0H02100 ^@ http://purl.uniprot.org/uniprot/G8ZZM5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/4950:TDEL_0A01760 ^@ http://purl.uniprot.org/uniprot/G8ZLL4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily. http://togogenome.org/gene/4950:TDEL_0A02760 ^@ http://purl.uniprot.org/uniprot/G8ZLW4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/4950:TDEL_0H02080 ^@ http://purl.uniprot.org/uniprot/G8ZZM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A04370 ^@ http://purl.uniprot.org/uniprot/G8ZMC5 ^@ Similarity ^@ Belongs to the guanylate kinase family. http://togogenome.org/gene/4950:TDEL_0D02860 ^@ http://purl.uniprot.org/uniprot/G8ZTC6 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/4950:TDEL_0G00330 ^@ http://purl.uniprot.org/uniprot/G8ZYC5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D05630 ^@ http://purl.uniprot.org/uniprot/G8ZU53 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/4950:TDEL_0B06850 ^@ http://purl.uniprot.org/uniprot/G8ZQC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H3 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C06370 ^@ http://purl.uniprot.org/uniprot/G8ZQN9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRM1 family.|||Cell membrane|||Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/4950:TDEL_0G01940 ^@ http://purl.uniprot.org/uniprot/G8ZYT6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0A02980 ^@ http://purl.uniprot.org/uniprot/G8ZLY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF5 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E03590 ^@ http://purl.uniprot.org/uniprot/G8ZVF8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/4950:TDEL_0D00700 ^@ http://purl.uniprot.org/uniprot/G8ZSR0 ^@ Similarity ^@ Belongs to the peptidase M28 family. M28B subfamily. http://togogenome.org/gene/4950:TDEL_0E03750 ^@ http://purl.uniprot.org/uniprot/G8ZVH4 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/4950:TDEL_0F03990 ^@ http://purl.uniprot.org/uniprot/G8ZX66 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0E03510 ^@ http://purl.uniprot.org/uniprot/G8ZVF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein-DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Plays also a role in mtDNA replication. Has G-quadruplex (G4) unwinding activity and can suppress G4-induced genome instability when PIF1 levels are low.|||Belongs to the helicase family. PIF1 subfamily.|||Nucleus|||telomere http://togogenome.org/gene/4950:TDEL_0B02730 ^@ http://purl.uniprot.org/uniprot/G8ZP58 ^@ Similarity ^@ Belongs to the ETT1 family. http://togogenome.org/gene/4950:TDEL_0D05470 ^@ http://purl.uniprot.org/uniprot/G8ZU37 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/4950:TDEL_0F05370 ^@ http://purl.uniprot.org/uniprot/G8ZXK4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Endoplasmic reticulum membrane|||Functions as a zinc transporter.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/4950:TDEL_0E02910 ^@ http://purl.uniprot.org/uniprot/G8ZV90 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/4950:TDEL_0A07070 ^@ http://purl.uniprot.org/uniprot/G8ZN45 ^@ Function|||Similarity ^@ Belongs to the cyclin family.|||G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition. http://togogenome.org/gene/4950:TDEL_0B03960 ^@ http://purl.uniprot.org/uniprot/G8ZPI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0C01080 ^@ http://purl.uniprot.org/uniprot/G8ZR55 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/4950:TDEL_0G03360 ^@ http://purl.uniprot.org/uniprot/G8ZXT6 ^@ Function|||Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. http://togogenome.org/gene/4950:TDEL_0E02380 ^@ http://purl.uniprot.org/uniprot/G8ZV37 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/4950:TDEL_0C00470 ^@ http://purl.uniprot.org/uniprot/G8ZQZ4 ^@ Function|||Similarity ^@ Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.|||Belongs to the actin family. http://togogenome.org/gene/4950:TDEL_0A02190 ^@ http://purl.uniprot.org/uniprot/G8ZLQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ku80 family.|||Nucleus|||telomere http://togogenome.org/gene/4950:TDEL_0B01490 ^@ http://purl.uniprot.org/uniprot/G8ZNT4 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/4950:TDEL_0C04560 ^@ http://purl.uniprot.org/uniprot/G8ZS53 ^@ Similarity ^@ Belongs to the SUN family. http://togogenome.org/gene/4950:TDEL_0F01980 ^@ http://purl.uniprot.org/uniprot/G8ZWL5 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase II family. http://togogenome.org/gene/4950:TDEL_0D06510 ^@ http://purl.uniprot.org/uniprot/G8ZUE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A05640 ^@ http://purl.uniprot.org/uniprot/G8ZMQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SFR1/MEI5 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E05610 ^@ http://purl.uniprot.org/uniprot/G8ZW10 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0A04280 ^@ http://purl.uniprot.org/uniprot/G8ZMB6 ^@ Function|||Subcellular Location Annotation ^@ Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation.|||Nucleus http://togogenome.org/gene/4950:TDEL_0H03150 ^@ http://purl.uniprot.org/uniprot/G8ZZY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMA20 family.|||Cytoplasm|||Involved in translation. http://togogenome.org/gene/4950:TDEL_0D06250 ^@ http://purl.uniprot.org/uniprot/G8ZUB5 ^@ Function|||Similarity ^@ Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.|||In the C-terminal section; belongs to the AIR synthase family.|||In the N-terminal section; belongs to the GARS family. http://togogenome.org/gene/4950:TDEL_0E03260 ^@ http://purl.uniprot.org/uniprot/G8ZVC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0D01250 ^@ http://purl.uniprot.org/uniprot/G8ZSW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-50 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D00450 ^@ http://purl.uniprot.org/uniprot/G8ZSN5 ^@ Similarity ^@ Belongs to the proteasome subunit S5A family. http://togogenome.org/gene/4950:TDEL_0A00260 ^@ http://purl.uniprot.org/uniprot/G8ZL64 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/4950:TDEL_0E03740 ^@ http://purl.uniprot.org/uniprot/G8ZVH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid/polyamine transporter 2 family.|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0A02840 ^@ http://purl.uniprot.org/uniprot/G8ZLX2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family. http://togogenome.org/gene/4950:TDEL_0D02770 ^@ http://purl.uniprot.org/uniprot/G8ZTB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 72 family.|||Cell membrane|||Membrane|||Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. http://togogenome.org/gene/4950:TDEL_0H02820 ^@ http://purl.uniprot.org/uniprot/G8ZZU7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0H01040 ^@ http://purl.uniprot.org/uniprot/G8ZZB9 ^@ Similarity ^@ Belongs to the AIM23 family. http://togogenome.org/gene/4950:TDEL_0B00280 ^@ http://purl.uniprot.org/uniprot/G8ZNG3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/4950:TDEL_0B07210 ^@ http://purl.uniprot.org/uniprot/G8ZQF6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.|||Heterodimer of an alpha and a beta chain.|||Mitochondrion matrix|||The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion. http://togogenome.org/gene/4950:TDEL_0B03470 ^@ http://purl.uniprot.org/uniprot/G8ZPD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRS1 family.|||Involved in ribosomal large subunit assembly.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A02150 ^@ http://purl.uniprot.org/uniprot/G8ZLQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||actin patch http://togogenome.org/gene/4950:TDEL_0G04300 ^@ http://purl.uniprot.org/uniprot/G8ZY30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.|||nucleolus http://togogenome.org/gene/4950:TDEL_0E03760 ^@ http://purl.uniprot.org/uniprot/G8ZVH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A04400 ^@ http://purl.uniprot.org/uniprot/G8ZMC8 ^@ Similarity ^@ Belongs to the RAD52 family. http://togogenome.org/gene/4950:TDEL_0A02730 ^@ http://purl.uniprot.org/uniprot/G8ZLW1 ^@ Similarity ^@ Belongs to the UPL family. K-HECT subfamily. http://togogenome.org/gene/4950:TDEL_0E02900 ^@ http://purl.uniprot.org/uniprot/G8ZV89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB1 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C03540 ^@ http://purl.uniprot.org/uniprot/G8ZRV1 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/4950:TDEL_0B06420 ^@ http://purl.uniprot.org/uniprot/G8ZQ77 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/4950:TDEL_0F04780 ^@ http://purl.uniprot.org/uniprot/G8ZXE5 ^@ Similarity ^@ Belongs to the spermidine/spermine synthase family. http://togogenome.org/gene/4950:TDEL_0F01490 ^@ http://purl.uniprot.org/uniprot/G8ZWG6 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. http://togogenome.org/gene/4950:TDEL_0C05410 ^@ http://purl.uniprot.org/uniprot/G8ZSD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.|||cytoskeleton http://togogenome.org/gene/4950:TDEL_0B01810 ^@ http://purl.uniprot.org/uniprot/G8ZNW6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0B05970 ^@ http://purl.uniprot.org/uniprot/G8ZQ32 ^@ Similarity ^@ Belongs to the WD repeat LST8 family. http://togogenome.org/gene/4950:TDEL_0B04540 ^@ http://purl.uniprot.org/uniprot/G8ZPN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0C03490 ^@ http://purl.uniprot.org/uniprot/G8ZRU6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/4950:TDEL_0G04400 ^@ http://purl.uniprot.org/uniprot/G8ZY40 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0G01920 ^@ http://purl.uniprot.org/uniprot/G8ZYT4 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/4950:TDEL_0C03210 ^@ http://purl.uniprot.org/uniprot/G8ZRR8 ^@ Similarity ^@ Belongs to the TIP41 family. http://togogenome.org/gene/4950:TDEL_0H00620 ^@ http://purl.uniprot.org/uniprot/G8ZZ77 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/4950:TDEL_0B03360 ^@ http://purl.uniprot.org/uniprot/G8ZPC1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 76 family. http://togogenome.org/gene/4950:TDEL_0D02960 ^@ http://purl.uniprot.org/uniprot/G8ZTD6 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/4950:TDEL_0D04730 ^@ http://purl.uniprot.org/uniprot/G8ZTW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NUF2 family.|||kinetochore http://togogenome.org/gene/4950:TDEL_0E03070 ^@ http://purl.uniprot.org/uniprot/G8ZVA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGF family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0D06400 ^@ http://purl.uniprot.org/uniprot/G8ZUD0 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/4950:TDEL_0D01990 ^@ http://purl.uniprot.org/uniprot/G8ZT39 ^@ Similarity ^@ Belongs to the helicase family. SKI2 subfamily. http://togogenome.org/gene/4950:TDEL_0A05160 ^@ http://purl.uniprot.org/uniprot/G8ZMK4 ^@ Subcellular Location Annotation ^@ Mitochondrion outer membrane http://togogenome.org/gene/4950:TDEL_0H04280 ^@ http://purl.uniprot.org/uniprot/G9A093 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/4950:TDEL_0F00210 ^@ http://purl.uniprot.org/uniprot/G8ZW38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0C04430 ^@ http://purl.uniprot.org/uniprot/G8ZS40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom7 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/4950:TDEL_0B03560 ^@ http://purl.uniprot.org/uniprot/G8ZPE1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0C05370 ^@ http://purl.uniprot.org/uniprot/G8ZSD4 ^@ Function|||Similarity ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. http://togogenome.org/gene/4950:TDEL_0E02320 ^@ http://purl.uniprot.org/uniprot/G8ZV31 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/4950:TDEL_0D03140 ^@ http://purl.uniprot.org/uniprot/G8ZTF4 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/4950:TDEL_0C01420 ^@ http://purl.uniprot.org/uniprot/G8ZR89 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/4950:TDEL_0B02480 ^@ http://purl.uniprot.org/uniprot/G8ZP33 ^@ Similarity ^@ Belongs to the nucleoporin Nup133 family. http://togogenome.org/gene/4950:TDEL_0A05090 ^@ http://purl.uniprot.org/uniprot/G8ZMJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MEF2 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A02280 ^@ http://purl.uniprot.org/uniprot/G8ZLR6 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/4950:TDEL_0D06590 ^@ http://purl.uniprot.org/uniprot/G8ZUE9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0B01970 ^@ http://purl.uniprot.org/uniprot/G8ZTQ4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/4950:TDEL_0A02880 ^@ http://purl.uniprot.org/uniprot/G8ZLX6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Binds 2 magnesium ions. Also active with manganese.|||Nucleus|||Polymerase that creates the 3'-poly(A) tail of mRNA's. http://togogenome.org/gene/4950:TDEL_0E04700 ^@ http://purl.uniprot.org/uniprot/G8ZVR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC9 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B05010 ^@ http://purl.uniprot.org/uniprot/G8ZPT6 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/4950:TDEL_0B04590 ^@ http://purl.uniprot.org/uniprot/G8ZPP4 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/4950:TDEL_0A02870 ^@ http://purl.uniprot.org/uniprot/G8ZLX5 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/4950:TDEL_0D00250 ^@ http://purl.uniprot.org/uniprot/G8ZSL5 ^@ Similarity ^@ Belongs to the oxoprolinase family. http://togogenome.org/gene/4950:TDEL_0B03750 ^@ http://purl.uniprot.org/uniprot/G8ZPG0 ^@ Similarity ^@ Belongs to the uroporphyrinogen-III synthase family. http://togogenome.org/gene/4950:TDEL_0B02390 ^@ http://purl.uniprot.org/uniprot/G8ZP24 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/4950:TDEL_0G04870 ^@ http://purl.uniprot.org/uniprot/G8ZY87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0C04200 ^@ http://purl.uniprot.org/uniprot/G8ZS17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0A05530 ^@ http://purl.uniprot.org/uniprot/G8ZMP1 ^@ Similarity ^@ Belongs to the peptidase C14B family. http://togogenome.org/gene/4950:TDEL_0E03580 ^@ http://purl.uniprot.org/uniprot/G8ZVF7 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/4950:TDEL_0B07430 ^@ http://purl.uniprot.org/uniprot/G8ZQH8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.|||Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). SPC associates with the translocon complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0F04270 ^@ http://purl.uniprot.org/uniprot/G8ZX94 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx5 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/4950:TDEL_0G03230 ^@ http://purl.uniprot.org/uniprot/G8ZXS3 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Homodimer. http://togogenome.org/gene/4950:TDEL_0B06170 ^@ http://purl.uniprot.org/uniprot/G8ZQ52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B01350 ^@ http://purl.uniprot.org/uniprot/G8ZNS0 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/4950:TDEL_0A05180 ^@ http://purl.uniprot.org/uniprot/G8ZMK6 ^@ Similarity ^@ Belongs to the transglutaminase-like superfamily. PNGase family. http://togogenome.org/gene/4950:TDEL_0G04030 ^@ http://purl.uniprot.org/uniprot/G8ZY03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CND1 (condensin subunit 1) family.|||Chromosome|||Nucleus|||Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. http://togogenome.org/gene/4950:TDEL_0B04620 ^@ http://purl.uniprot.org/uniprot/G8ZPP7 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family.|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. http://togogenome.org/gene/4950:TDEL_0E04760 ^@ http://purl.uniprot.org/uniprot/G8ZVS5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sulfate adenylyltransferase family.|||Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.|||Cytoplasm|||Homohexamer. Dimer of trimers.|||The oligomerization domain is distantly related to APS kinases, but it is not functional and does not bind APS. It is required for oligomerization of the enzyme, although the oligomerization state has no effect on the catalytic activity of the enzyme. http://togogenome.org/gene/4950:TDEL_0C06770 ^@ http://purl.uniprot.org/uniprot/G8ZQS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPS2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0H01590 ^@ http://purl.uniprot.org/uniprot/G8ZZH4 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/4950:TDEL_0B05350 ^@ http://purl.uniprot.org/uniprot/G8ZPX0 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rieske iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Membrane|||Mitochondrion inner membrane|||The Rieske protein is a high potential 2Fe-2S protein. http://togogenome.org/gene/4950:TDEL_0C01910 ^@ http://purl.uniprot.org/uniprot/G8ZRD8 ^@ Function|||Similarity|||Subunit ^@ Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.|||Belongs to the NMT family.|||Monomer. http://togogenome.org/gene/4950:TDEL_0H02730 ^@ http://purl.uniprot.org/uniprot/G8ZZT8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 22 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0B06860 ^@ http://purl.uniprot.org/uniprot/G8ZQC1 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/4950:TDEL_0H01240 ^@ http://purl.uniprot.org/uniprot/G8ZZD9 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/4950:TDEL_0E03970 ^@ http://purl.uniprot.org/uniprot/G8ZVJ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.|||Belongs to the NSE1 family.|||Component of the Smc5-Smc6 complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A06620 ^@ http://purl.uniprot.org/uniprot/G8ZN00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/4950:TDEL_0A04120 ^@ http://purl.uniprot.org/uniprot/G8ZMA0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GPI19 family.|||Component of the phosphatidylinositol N-acetylglucosaminyltransferase (GPI-GlcNAc transferase) complex.|||Endoplasmic reticulum membrane|||Membrane|||Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. http://togogenome.org/gene/4950:TDEL_0B06560 ^@ http://purl.uniprot.org/uniprot/G8ZQ91 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0H01920 ^@ http://purl.uniprot.org/uniprot/G8ZZK7 ^@ Function|||Similarity ^@ Belongs to the ARPC5 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. http://togogenome.org/gene/4950:TDEL_0E05010 ^@ http://purl.uniprot.org/uniprot/G8ZVV0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 3-HAO family.|||Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0G01850 ^@ http://purl.uniprot.org/uniprot/G8ZYS7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0A01270 ^@ http://purl.uniprot.org/uniprot/G8ZLG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RAD3/XPD subfamily.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C01160 ^@ http://purl.uniprot.org/uniprot/G8ZR63 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/4950:TDEL_0D04860 ^@ http://purl.uniprot.org/uniprot/G8ZTX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||Nucleus|||Required for pre-mRNA splicing. http://togogenome.org/gene/4950:TDEL_0B03950 ^@ http://purl.uniprot.org/uniprot/G8ZPI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Membrane|||nuclear pore complex http://togogenome.org/gene/4950:TDEL_0G04410 ^@ http://purl.uniprot.org/uniprot/G8ZY41 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.|||Endoplasmic reticulum membrane|||Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/4950:TDEL_0D03590 ^@ http://purl.uniprot.org/uniprot/G8ZTJ9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/4950:TDEL_0D04210 ^@ http://purl.uniprot.org/uniprot/G8ZTR1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGV family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.|||Membrane http://togogenome.org/gene/4950:TDEL_0C02280 ^@ http://purl.uniprot.org/uniprot/G8ZRH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC123 family.|||Cytoplasm|||Regulates the cell cycle in a nutrient dependent manner. http://togogenome.org/gene/4950:TDEL_0A03080 ^@ http://purl.uniprot.org/uniprot/G8ZLZ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP18 family.|||Golgi apparatus membrane|||Golgi membrane protein involved in vesicular trafficking.|||Membrane http://togogenome.org/gene/4950:TDEL_0C06270 ^@ http://purl.uniprot.org/uniprot/G8ZQM9 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0F03230 ^@ http://purl.uniprot.org/uniprot/G8ZWZ0 ^@ Function|||Similarity ^@ Belongs to the RRG8 family.|||Required for respiratory activity and maintenance and expression of the mitochondrial genome. http://togogenome.org/gene/4950:TDEL_0A00230 ^@ http://purl.uniprot.org/uniprot/G8ZL61 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS3/PSF3 family.|||Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication. http://togogenome.org/gene/4950:TDEL_0A07460 ^@ http://purl.uniprot.org/uniprot/G8ZN84 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0H04360 ^@ http://purl.uniprot.org/uniprot/G9A0A1 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/4950:TDEL_0D03640 ^@ http://purl.uniprot.org/uniprot/G8ZTK4 ^@ Similarity ^@ Belongs to the WrbA family. http://togogenome.org/gene/4950:TDEL_0D00290 ^@ http://purl.uniprot.org/uniprot/G8ZSL9 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/4950:TDEL_0E03830 ^@ http://purl.uniprot.org/uniprot/G8ZVI2 ^@ Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family.|||Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences. http://togogenome.org/gene/4950:TDEL_0F02490 ^@ http://purl.uniprot.org/uniprot/G8ZWR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/4950:TDEL_0B05790 ^@ http://purl.uniprot.org/uniprot/G8ZQ14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0D02470 ^@ http://purl.uniprot.org/uniprot/G8ZT87 ^@ Similarity ^@ Belongs to the complex I LYR family. SDHAF1 subfamily. http://togogenome.org/gene/4950:TDEL_0C01280 ^@ http://purl.uniprot.org/uniprot/G8ZR75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0F01110 ^@ http://purl.uniprot.org/uniprot/G8ZWC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0H04310 ^@ http://purl.uniprot.org/uniprot/G9A096 ^@ Function|||Similarity ^@ Belongs to the peptidase T1A family.|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. http://togogenome.org/gene/4950:TDEL_0C06650 ^@ http://purl.uniprot.org/uniprot/G8ZQR7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0H02030 ^@ http://purl.uniprot.org/uniprot/G8ZZL8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0F01520 ^@ http://purl.uniprot.org/uniprot/G8ZWG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLASP family.|||spindle http://togogenome.org/gene/4950:TDEL_0A03560 ^@ http://purl.uniprot.org/uniprot/G8ZM44 ^@ Similarity ^@ Belongs to the IUNH family. http://togogenome.org/gene/4950:TDEL_0D05410 ^@ http://purl.uniprot.org/uniprot/G8ZU31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0H04200 ^@ http://purl.uniprot.org/uniprot/G9A085 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/4950:TDEL_0A04390 ^@ http://purl.uniprot.org/uniprot/G8ZMC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NDC1 family.|||Membrane|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/4950:TDEL_0G02420 ^@ http://purl.uniprot.org/uniprot/G8ZYY4 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit beta family. http://togogenome.org/gene/4950:TDEL_0A04550 ^@ http://purl.uniprot.org/uniprot/G8ZME3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/4950:TDEL_0G02120 ^@ http://purl.uniprot.org/uniprot/G8ZYV4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0B03400 ^@ http://purl.uniprot.org/uniprot/G8ZPC5 ^@ Similarity ^@ Belongs to the MBF1 family. http://togogenome.org/gene/4950:TDEL_0F00830 ^@ http://purl.uniprot.org/uniprot/G8ZWA0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/4950:TDEL_0D00280 ^@ http://purl.uniprot.org/uniprot/G8ZSL8 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/4950:TDEL_0D06200 ^@ http://purl.uniprot.org/uniprot/G8ZUB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0B01980 ^@ http://purl.uniprot.org/uniprot/G8ZNY3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/4950:TDEL_0A06750 ^@ http://purl.uniprot.org/uniprot/G8ZN13 ^@ Subcellular Location Annotation ^@ telomere http://togogenome.org/gene/4950:TDEL_0C02580 ^@ http://purl.uniprot.org/uniprot/G8ZRK5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.|||Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/4950:TDEL_0C02930 ^@ http://purl.uniprot.org/uniprot/G8ZRP0 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/4950:TDEL_0H01710 ^@ http://purl.uniprot.org/uniprot/G8ZZI6 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0E04090 ^@ http://purl.uniprot.org/uniprot/G8ZVK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid/polyamine transporter 2 family.|||Vacuole membrane http://togogenome.org/gene/4950:TDEL_0A05900 ^@ http://purl.uniprot.org/uniprot/G8ZMS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0D02820 ^@ http://purl.uniprot.org/uniprot/G8ZTC2 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL10 family.|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome. http://togogenome.org/gene/4950:TDEL_0G03750 ^@ http://purl.uniprot.org/uniprot/G8ZXX5 ^@ Function ^@ Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates. http://togogenome.org/gene/4950:TDEL_0B05260 ^@ http://purl.uniprot.org/uniprot/G8ZPW1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/4950:TDEL_0G01770 ^@ http://purl.uniprot.org/uniprot/G8ZYR9 ^@ Function|||Similarity ^@ Belongs to the VPS13 family.|||Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis. http://togogenome.org/gene/4950:TDEL_0A05810 ^@ http://purl.uniprot.org/uniprot/G8ZMR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM41 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0D06600 ^@ http://purl.uniprot.org/uniprot/G8ZUF0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/4950:TDEL_0D04160 ^@ http://purl.uniprot.org/uniprot/G8ZTQ6 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/4950:TDEL_0H01690 ^@ http://purl.uniprot.org/uniprot/G8ZZI4 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/4950:TDEL_0E02850 ^@ http://purl.uniprot.org/uniprot/G8ZV84 ^@ Domain|||Function|||Similarity ^@ Belongs to the IPK1 type 1 family.|||Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.|||Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).|||The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2. http://togogenome.org/gene/4950:TDEL_0C02630 ^@ http://purl.uniprot.org/uniprot/G8ZRL0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits. http://togogenome.org/gene/4950:TDEL_0G02720 ^@ http://purl.uniprot.org/uniprot/G8ZZ14 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE4 family.|||Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.|||Component of the SMC5-SMC6 complex.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A04860 ^@ http://purl.uniprot.org/uniprot/G8ZMH4 ^@ Similarity ^@ Belongs to the APC13 family. http://togogenome.org/gene/4950:TDEL_0A07670 ^@ http://purl.uniprot.org/uniprot/G8ZNA5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/4950:TDEL_0F01410 ^@ http://purl.uniprot.org/uniprot/G8ZWF8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS7 family. http://togogenome.org/gene/4950:TDEL_0F00790 ^@ http://purl.uniprot.org/uniprot/G8ZW96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IBD2 family.|||spindle pole http://togogenome.org/gene/4950:TDEL_0G02040 ^@ http://purl.uniprot.org/uniprot/G8ZYU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 3 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0A00420 ^@ http://purl.uniprot.org/uniprot/G8ZL80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0F00150 ^@ http://purl.uniprot.org/uniprot/G8ZW32 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) per subunit. http://togogenome.org/gene/4950:TDEL_0D04930 ^@ http://purl.uniprot.org/uniprot/G8ZTY3 ^@ Similarity ^@ Belongs to the MDM20/NAA25 family. http://togogenome.org/gene/4950:TDEL_0H01860 ^@ http://purl.uniprot.org/uniprot/G8ZZK1 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/4950:TDEL_0E03020 ^@ http://purl.uniprot.org/uniprot/G8ZVA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS41 family.|||Mitochondrion http://togogenome.org/gene/4950:TDEL_0F00730 ^@ http://purl.uniprot.org/uniprot/G8ZW90 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/4950:TDEL_0G02810 ^@ http://purl.uniprot.org/uniprot/G8ZZ23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E02270 ^@ http://purl.uniprot.org/uniprot/G8ZV26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVF1 family.|||Cytoplasm http://togogenome.org/gene/4950:TDEL_0A01580 ^@ http://purl.uniprot.org/uniprot/G8ZLJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Membrane http://togogenome.org/gene/4950:TDEL_0H03230 ^@ http://purl.uniprot.org/uniprot/G8ZZY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAN1 family.|||Cell membrane|||Endosome membrane|||Membrane|||actin patch http://togogenome.org/gene/4950:TDEL_0B00960 ^@ http://purl.uniprot.org/uniprot/G8ZNN1 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/4950:TDEL_0F05310 ^@ http://purl.uniprot.org/uniprot/G8ZXJ8 ^@ Function|||Similarity ^@ Belongs to the LipB family.|||Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. http://togogenome.org/gene/4950:TDEL_0E04180 ^@ http://purl.uniprot.org/uniprot/G8ZVL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/4950:TDEL_0A06050 ^@ http://purl.uniprot.org/uniprot/G8ZMU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP53 family.|||May play a role in ribosome biogenesis.|||nucleolus|||nucleoplasm http://togogenome.org/gene/4950:TDEL_0B01870 ^@ http://purl.uniprot.org/uniprot/G8ZNX2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL10 family. http://togogenome.org/gene/4950:TDEL_0C05550 ^@ http://purl.uniprot.org/uniprot/G8ZSF2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0E00610 ^@ http://purl.uniprot.org/uniprot/G8ZUL0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS19 family. http://togogenome.org/gene/4950:TDEL_0A03740 ^@ http://purl.uniprot.org/uniprot/G8ZM62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0H03780 ^@ http://purl.uniprot.org/uniprot/G9A043 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/4950:TDEL_0H00690 ^@ http://purl.uniprot.org/uniprot/G8ZZ84 ^@ Similarity ^@ Belongs to the proteasome subunit S3 family. http://togogenome.org/gene/4950:TDEL_0A03780 ^@ http://purl.uniprot.org/uniprot/G8ZM66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP17 family.|||nucleolus http://togogenome.org/gene/4950:TDEL_0D02350 ^@ http://purl.uniprot.org/uniprot/G8ZT75 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/4950:TDEL_0D03440 ^@ http://purl.uniprot.org/uniprot/G8ZTI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLT11 family.|||Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.|||Nucleus http://togogenome.org/gene/4950:TDEL_0H00490 ^@ http://purl.uniprot.org/uniprot/G8ZZ64 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/4950:TDEL_0H03790 ^@ http://purl.uniprot.org/uniprot/G9A044 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/4950:TDEL_0H01670 ^@ http://purl.uniprot.org/uniprot/G8ZZI2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GET2 family.|||Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. http://togogenome.org/gene/4950:TDEL_0F04490 ^@ http://purl.uniprot.org/uniprot/G8ZXB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF12 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G01990 ^@ http://purl.uniprot.org/uniprot/G8ZYU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG27 family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/4950:TDEL_0C00210 ^@ http://purl.uniprot.org/uniprot/G8ZQW8 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/4950:TDEL_0A07920 ^@ http://purl.uniprot.org/uniprot/G8ZND0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0B05540 ^@ http://purl.uniprot.org/uniprot/G8ZPY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NSE2 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G02840 ^@ http://purl.uniprot.org/uniprot/G8ZXN4 ^@ Similarity ^@ Belongs to the ATG16 family. http://togogenome.org/gene/4950:TDEL_0F02070 ^@ http://purl.uniprot.org/uniprot/G8ZWM4 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.|||In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. http://togogenome.org/gene/4950:TDEL_0D01740 ^@ http://purl.uniprot.org/uniprot/G8ZT14 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/4950:TDEL_0E05620 ^@ http://purl.uniprot.org/uniprot/G8ZW11 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/4950:TDEL_0A03060 ^@ http://purl.uniprot.org/uniprot/G8ZLZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA40 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/4950:TDEL_0C05980 ^@ http://purl.uniprot.org/uniprot/G8ZSJ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UbiH/COQ6 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0H04450 ^@ http://purl.uniprot.org/uniprot/G9A0B0 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/4950:TDEL_0F02080 ^@ http://purl.uniprot.org/uniprot/G8ZWM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TEC1 family.|||Nucleus http://togogenome.org/gene/4950:TDEL_0E04710 ^@ http://purl.uniprot.org/uniprot/G8ZVS0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 16 family. http://togogenome.org/gene/4950:TDEL_0C04150 ^@ http://purl.uniprot.org/uniprot/G8ZS12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||nucleolus http://togogenome.org/gene/4950:TDEL_0F01390 ^@ http://purl.uniprot.org/uniprot/G8ZWF6 ^@ Similarity ^@ Belongs to the glycosyltransferase 15 family. http://togogenome.org/gene/4950:TDEL_0C06960 ^@ http://purl.uniprot.org/uniprot/G8ZQU8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KRR1 family.|||Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.|||Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.|||nucleolus http://togogenome.org/gene/4950:TDEL_0C01960 ^@ http://purl.uniprot.org/uniprot/G8ZRE3 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/4950:TDEL_0F05210 ^@ http://purl.uniprot.org/uniprot/G8ZXI8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/4950:TDEL_0D04000 ^@ http://purl.uniprot.org/uniprot/G8ZTP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chitin synthase family.|||Cell membrane|||Membrane|||Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer. http://togogenome.org/gene/4950:TDEL_0E03730 ^@ http://purl.uniprot.org/uniprot/G8ZVH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.|||Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/4950:TDEL_0C01510 ^@ http://purl.uniprot.org/uniprot/G8ZR98 ^@ Similarity ^@ Belongs to the AAR2 family. http://togogenome.org/gene/4950:TDEL_0H02770 ^@ http://purl.uniprot.org/uniprot/G8ZZU2 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/4950:TDEL_0G00240 ^@ http://purl.uniprot.org/uniprot/G8ZYB6 ^@ Function|||Similarity ^@ Belongs to the peptidase T1A family.|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. http://togogenome.org/gene/4950:TDEL_0H01970 ^@ http://purl.uniprot.org/uniprot/G8ZZL2 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.|||Can also use Mn(2+) ion. http://togogenome.org/gene/4950:TDEL_0E05480 ^@ http://purl.uniprot.org/uniprot/G8ZVZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat COPB2 family.|||COPI-coated vesicle membrane|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/4950:TDEL_0H03940 ^@ http://purl.uniprot.org/uniprot/G9A059 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 8 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/4950:TDEL_0F05460 ^@ http://purl.uniprot.org/uniprot/G8ZXL3 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/4950:TDEL_0E04150 ^@ http://purl.uniprot.org/uniprot/G8ZVL4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/4950:TDEL_0D00990 ^@ http://purl.uniprot.org/uniprot/G8ZST9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/4950:TDEL_0G00500 ^@ http://purl.uniprot.org/uniprot/G8ZYE2 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/4950:TDEL_0G01820 ^@ http://purl.uniprot.org/uniprot/G8ZYS4 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/4950:TDEL_0E05460 ^@ http://purl.uniprot.org/uniprot/G8ZVZ5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL1 family. http://togogenome.org/gene/4950:TDEL_0B04150 ^@ http://purl.uniprot.org/uniprot/G8ZPK0 ^@ Similarity ^@ In the C-terminal section; belongs to the trehalose phosphatase family.|||In the N-terminal section; belongs to the glycosyltransferase 20 family. http://togogenome.org/gene/4950:TDEL_0A05070 ^@ http://purl.uniprot.org/uniprot/G8ZMJ5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. http://togogenome.org/gene/4950:TDEL_0G03560 ^@ http://purl.uniprot.org/uniprot/G8ZXV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DASH complex DUO1 family.|||Nucleus|||kinetochore http://togogenome.org/gene/4950:TDEL_0C02170 ^@ http://purl.uniprot.org/uniprot/G8ZRG4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0B02460 ^@ http://purl.uniprot.org/uniprot/G8ZP31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shugoshin family.|||centromere http://togogenome.org/gene/4950:TDEL_0G02680 ^@ http://purl.uniprot.org/uniprot/G8ZZ10 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/4950:TDEL_0C02310 ^@ http://purl.uniprot.org/uniprot/G8ZRH8 ^@ Similarity ^@ Belongs to the biotin--protein ligase family. http://togogenome.org/gene/4950:TDEL_0C02110 ^@ http://purl.uniprot.org/uniprot/G8ZRF8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/4950:TDEL_0C05080 ^@ http://purl.uniprot.org/uniprot/G8ZSA5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least SUS1, SAC3, THP1, SEM1, and CDC31. TREX-2 contains 2 SUS1 chains. The TREX-2 complex interacts with the nucleoporin NUP1. Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with THP1, SAC3, SGF11, and with the RNA polymerase II.|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies.|||P-body|||nucleoplasm http://togogenome.org/gene/4950:TDEL_0B01750 ^@ http://purl.uniprot.org/uniprot/G8ZNW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GLE1 family.|||nuclear pore complex http://togogenome.org/gene/4950:TDEL_0C01070 ^@ http://purl.uniprot.org/uniprot/G8ZR54 ^@ Similarity ^@ Belongs to the RRP12 family. http://togogenome.org/gene/4950:TDEL_0H00700 ^@ http://purl.uniprot.org/uniprot/G8ZZ85 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48A family.|||Binds 1 zinc ion per subunit.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Proteolytically removes the C-terminal three residues of farnesylated proteins. http://togogenome.org/gene/4950:TDEL_0B03610 ^@ http://purl.uniprot.org/uniprot/G8ZPE6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with 90S and pre-40S pre-ribosomal particles.|||Belongs to the RRP36 family.|||Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.|||nucleolus