http://togogenome.org/gene/521045:KOLE_RS06020 ^@ http://purl.uniprot.org/uniprot/C5CIK9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 39 family. http://togogenome.org/gene/521045:KOLE_RS00035 ^@ http://purl.uniprot.org/uniprot/C5CH96 ^@ Function|||Similarity ^@ Belongs to the helicase family. RecG subfamily.|||Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA). http://togogenome.org/gene/521045:KOLE_RS05890 ^@ http://purl.uniprot.org/uniprot/C5CIK6 ^@ Similarity ^@ Belongs to the peptidase S9A family.|||Belongs to the peptidase S9C family. http://togogenome.org/gene/521045:KOLE_RS08805 ^@ http://purl.uniprot.org/uniprot/C5CFT4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS08900 ^@ http://purl.uniprot.org/uniprot/C5CFV0 ^@ Similarity ^@ Belongs to the polysaccharide synthase family. http://togogenome.org/gene/521045:KOLE_RS01300 ^@ http://purl.uniprot.org/uniprot/C5CD36 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.|||Cell inner membrane|||Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.|||Membrane|||Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. http://togogenome.org/gene/521045:KOLE_RS10675 ^@ http://purl.uniprot.org/uniprot/C5CI87 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family. DXPS subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS07290 ^@ http://purl.uniprot.org/uniprot/C5CE39 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-3 family.|||Cytoplasm|||IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.|||Monomer. http://togogenome.org/gene/521045:KOLE_RS10620 ^@ http://purl.uniprot.org/uniprot/C5CI76 ^@ Similarity ^@ Belongs to the ribF family. http://togogenome.org/gene/521045:KOLE_RS10830 ^@ http://purl.uniprot.org/uniprot/C5CIN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.|||Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.|||Cell inner membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS00420 ^@ http://purl.uniprot.org/uniprot/C5CHV4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS04905 ^@ http://purl.uniprot.org/uniprot/C5CH15 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS08700 ^@ http://purl.uniprot.org/uniprot/C5CFQ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS08630 ^@ http://purl.uniprot.org/uniprot/C5CFP6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/521045:KOLE_RS07900 ^@ http://purl.uniprot.org/uniprot/C5CES7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA(Ile)-lysidine synthase family.|||Cytoplasm|||Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.|||The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding. http://togogenome.org/gene/521045:KOLE_RS01780 ^@ http://purl.uniprot.org/uniprot/C5CDI7 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/521045:KOLE_RS01305 ^@ http://purl.uniprot.org/uniprot/C5CD37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0161 family.|||Cell inner membrane|||Could be involved in insertion of integral membrane proteins into the membrane. http://togogenome.org/gene/521045:KOLE_RS03980 ^@ http://purl.uniprot.org/uniprot/C5CG59 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS09335 ^@ http://purl.uniprot.org/uniprot/C5CGE8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase subunit omega family.|||Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/521045:KOLE_RS10835 ^@ http://purl.uniprot.org/uniprot/C5CIN8 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/521045:KOLE_RS01375 ^@ http://purl.uniprot.org/uniprot/C5CD51 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.|||Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain. http://togogenome.org/gene/521045:KOLE_RS00895 ^@ http://purl.uniprot.org/uniprot/C5CIG5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS10645 ^@ http://purl.uniprot.org/uniprot/C5CI81 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS10625 ^@ http://purl.uniprot.org/uniprot/C5CI77 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.|||Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/521045:KOLE_RS05000 ^@ http://purl.uniprot.org/uniprot/C5CH34 ^@ Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. http://togogenome.org/gene/521045:KOLE_RS10045 ^@ http://purl.uniprot.org/uniprot/C5CH65 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.|||Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.|||Homodimer.|||Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. http://togogenome.org/gene/521045:KOLE_RS10100 ^@ http://purl.uniprot.org/uniprot/C5CH76 ^@ Cofactor|||Similarity ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer. http://togogenome.org/gene/521045:KOLE_RS02675 ^@ http://purl.uniprot.org/uniprot/C5CEK1 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/521045:KOLE_RS03050 ^@ http://purl.uniprot.org/uniprot/C5CEY7 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/521045:KOLE_RS03555 ^@ http://purl.uniprot.org/uniprot/C5CFJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/521045:KOLE_RS09660 ^@ http://purl.uniprot.org/uniprot/C5CGS4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF2.|||Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. http://togogenome.org/gene/521045:KOLE_RS04735 ^@ http://purl.uniprot.org/uniprot/C5CGY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS00110 ^@ http://purl.uniprot.org/uniprot/C5CHB1 ^@ Similarity ^@ Belongs to the histone deacetylase family. http://togogenome.org/gene/521045:KOLE_RS06815 ^@ http://purl.uniprot.org/uniprot/C5CDP3 ^@ Similarity ^@ Belongs to the UDP-N-acetylglucosamine 2-epimerase family. http://togogenome.org/gene/521045:KOLE_RS01035 ^@ http://purl.uniprot.org/uniprot/C5CIT9 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family. http://togogenome.org/gene/521045:KOLE_RS08205 ^@ http://purl.uniprot.org/uniprot/C5CF51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/521045:KOLE_RS10070 ^@ http://purl.uniprot.org/uniprot/C5CH70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS04765 ^@ http://purl.uniprot.org/uniprot/C5CGY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUA5 family.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/521045:KOLE_RS09800 ^@ http://purl.uniprot.org/uniprot/C5CGV2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/521045:KOLE_RS03640 ^@ http://purl.uniprot.org/uniprot/C5CFL5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.|||Cell inner membrane|||Membrane|||Probable transporter of a GTP-driven Fe(2+) uptake system. http://togogenome.org/gene/521045:KOLE_RS01055 ^@ http://purl.uniprot.org/uniprot/C5CIU3 ^@ Similarity ^@ Belongs to the YggT family. http://togogenome.org/gene/521045:KOLE_RS01575 ^@ http://purl.uniprot.org/uniprot/C5CD91 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS09310 ^@ http://purl.uniprot.org/uniprot/C5CGE5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell inner membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. http://togogenome.org/gene/521045:KOLE_RS09680 ^@ http://purl.uniprot.org/uniprot/C5CGS8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Homodimer. http://togogenome.org/gene/521045:KOLE_RS07065 ^@ http://purl.uniprot.org/uniprot/C5CE00 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Belongs to the NnrE/AIBP family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Homotetramer.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS01820 ^@ http://purl.uniprot.org/uniprot/C5CDJ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/521045:KOLE_RS04305 ^@ http://purl.uniprot.org/uniprot/C5CGC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/521045:KOLE_RS09000 ^@ http://purl.uniprot.org/uniprot/C5CFX0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS07965 ^@ http://purl.uniprot.org/uniprot/C5CF01 ^@ Similarity ^@ Belongs to the LytR/CpsA/Psr (LCP) family. http://togogenome.org/gene/521045:KOLE_RS01330 ^@ http://purl.uniprot.org/uniprot/C5CD42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurB family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS11085 ^@ http://purl.uniprot.org/uniprot/C5CG91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS06850 ^@ http://purl.uniprot.org/uniprot/C5CDQ1 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/521045:KOLE_RS06210 ^@ http://purl.uniprot.org/uniprot/C5CJ12 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion.|||Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.|||In the C-terminal section; belongs to the HTP reductase family.|||In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/521045:KOLE_RS05960 ^@ http://purl.uniprot.org/uniprot/C5CIM1 ^@ Function|||Similarity ^@ Belongs to the NanE family.|||Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). http://togogenome.org/gene/521045:KOLE_RS06580 ^@ http://purl.uniprot.org/uniprot/C5CDD8 ^@ Similarity ^@ Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family. http://togogenome.org/gene/521045:KOLE_RS04025 ^@ http://purl.uniprot.org/uniprot/C5CG68 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS00260 ^@ http://purl.uniprot.org/uniprot/C5CHD7 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/521045:KOLE_RS00175 ^@ http://purl.uniprot.org/uniprot/C5CHC4 ^@ Function|||Similarity ^@ Belongs to the QueH family.|||Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). http://togogenome.org/gene/521045:KOLE_RS07670 ^@ http://purl.uniprot.org/uniprot/C5CEN2 ^@ Function|||Similarity ^@ ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.|||Belongs to the ParA family. MinD subfamily. http://togogenome.org/gene/521045:KOLE_RS02770 ^@ http://purl.uniprot.org/uniprot/C5CEL9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.|||Cytoplasm|||Interacts with 100S ribosomes.|||Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. http://togogenome.org/gene/521045:KOLE_RS01405 ^@ http://purl.uniprot.org/uniprot/C5CD57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS07220 ^@ http://purl.uniprot.org/uniprot/C5CE26 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/521045:KOLE_RS01280 ^@ http://purl.uniprot.org/uniprot/C5CD32 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. http://togogenome.org/gene/521045:KOLE_RS03405 ^@ http://purl.uniprot.org/uniprot/C5CFB0 ^@ Similarity ^@ In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.|||In the central section; belongs to the CRISPR-associated helicase Cas3 family. http://togogenome.org/gene/521045:KOLE_RS10305 ^@ http://purl.uniprot.org/uniprot/C5CHP2 ^@ Function|||Similarity ^@ Belongs to the thymidylate kinase family.|||Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. http://togogenome.org/gene/521045:KOLE_RS04295 ^@ http://purl.uniprot.org/uniprot/C5CGC0 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/521045:KOLE_RS00145 ^@ http://purl.uniprot.org/uniprot/C5CHB8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the thymidylate synthase ThyX family.|||Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.|||Homotetramer. http://togogenome.org/gene/521045:KOLE_RS10480 ^@ http://purl.uniprot.org/uniprot/C5CHS6 ^@ Similarity ^@ Belongs to the dihydropyrimidine dehydrogenase family. http://togogenome.org/gene/521045:KOLE_RS05565 ^@ http://purl.uniprot.org/uniprot/C5CI27 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS10420 ^@ http://purl.uniprot.org/uniprot/C5CHR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS04690 ^@ http://purl.uniprot.org/uniprot/C5CGX3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.|||Cytoplasm|||Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity. http://togogenome.org/gene/521045:KOLE_RS02820 ^@ http://purl.uniprot.org/uniprot/C5CEM7 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/521045:KOLE_RS08770 ^@ http://purl.uniprot.org/uniprot/C5CFS3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvA family.|||Cytoplasm|||Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.|||Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA. http://togogenome.org/gene/521045:KOLE_RS01450 ^@ http://purl.uniprot.org/uniprot/C5CD66 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit.|||Binds 2 divalent ions per subunit.|||Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.|||Cytoplasm|||Homotetramer; dimer of dimers. http://togogenome.org/gene/521045:KOLE_RS02230 ^@ http://purl.uniprot.org/uniprot/C5CE50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/521045:KOLE_RS02460 ^@ http://purl.uniprot.org/uniprot/C5CEA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS07755 ^@ http://purl.uniprot.org/uniprot/C5CEP9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/521045:KOLE_RS07210 ^@ http://purl.uniprot.org/uniprot/C5CE24 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/521045:KOLE_RS08340 ^@ http://purl.uniprot.org/uniprot/C5CFC9 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pantothenate synthetase family.|||Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.|||Cytoplasm|||Homodimer.|||The reaction proceeds by a bi uni uni bi ping pong mechanism. http://togogenome.org/gene/521045:KOLE_RS01410 ^@ http://purl.uniprot.org/uniprot/C5CD58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS05550 ^@ http://purl.uniprot.org/uniprot/C5CI24 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS07485 ^@ http://purl.uniprot.org/uniprot/C5CED7 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. Ycf16 family. http://togogenome.org/gene/521045:KOLE_RS07360 ^@ http://purl.uniprot.org/uniprot/C5CEB5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.|||Belongs to the RimM family.|||Binds ribosomal protein uS19.|||Cytoplasm|||The PRC barrel domain binds ribosomal protein uS19. http://togogenome.org/gene/521045:KOLE_RS10310 ^@ http://purl.uniprot.org/uniprot/C5CHP3 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/521045:KOLE_RS01615 ^@ http://purl.uniprot.org/uniprot/C5CDF9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial diacylglycerol kinase family.|||Membrane|||Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents. http://togogenome.org/gene/521045:KOLE_RS07595 ^@ http://purl.uniprot.org/uniprot/C5CEF7 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/521045:KOLE_RS04745 ^@ http://purl.uniprot.org/uniprot/C5CGY4 ^@ Similarity ^@ Belongs to the SorC transcriptional regulatory family. http://togogenome.org/gene/521045:KOLE_RS02905 ^@ http://purl.uniprot.org/uniprot/C5CEV3 ^@ Similarity ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. http://togogenome.org/gene/521045:KOLE_RS09195 ^@ http://purl.uniprot.org/uniprot/C5CG09 ^@ Similarity ^@ Belongs to the peptidase S9C family. http://togogenome.org/gene/521045:KOLE_RS10430 ^@ http://purl.uniprot.org/uniprot/C5CHR6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/521045:KOLE_RS10845 ^@ http://purl.uniprot.org/uniprot/C5CIP0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/521045:KOLE_RS04590 ^@ http://purl.uniprot.org/uniprot/C5CGN6 ^@ Caution|||Function|||Similarity ^@ Belongs to the DXR family.|||Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS01555 ^@ http://purl.uniprot.org/uniprot/C5CD87 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/521045:KOLE_RS01745 ^@ http://purl.uniprot.org/uniprot/C5CDH9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/521045:KOLE_RS08560 ^@ http://purl.uniprot.org/uniprot/C5CFH3 ^@ Cofactor|||Similarity ^@ Belongs to the ApbE family.|||Magnesium. Can also use manganese. http://togogenome.org/gene/521045:KOLE_RS09340 ^@ http://purl.uniprot.org/uniprot/C5CGE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylate kinase family.|||Cytoplasm|||Essential for recycling GMP and indirectly, cGMP. http://togogenome.org/gene/521045:KOLE_RS08910 ^@ http://purl.uniprot.org/uniprot/C5CFV2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS10060 ^@ http://purl.uniprot.org/uniprot/C5CH68 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/521045:KOLE_RS04965 ^@ http://purl.uniprot.org/uniprot/C5CH27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS06935 ^@ http://purl.uniprot.org/uniprot/C5CDR6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/521045:KOLE_RS01795 ^@ http://purl.uniprot.org/uniprot/C5CDJ0 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/521045:KOLE_RS08200 ^@ http://purl.uniprot.org/uniprot/B5M6L6 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/521045:KOLE_RS03110 ^@ http://purl.uniprot.org/uniprot/C5CEZ9 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/521045:KOLE_RS01275 ^@ http://purl.uniprot.org/uniprot/C5CD31 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/521045:KOLE_RS07510 ^@ http://purl.uniprot.org/uniprot/C5CEE2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/521045:KOLE_RS04605 ^@ http://purl.uniprot.org/uniprot/C5CGP2 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by fructose 1,6-bisphosphate (FBP).|||Belongs to the LDH/MDH superfamily. LDH family.|||Catalyzes the conversion of lactate to pyruvate.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/521045:KOLE_RS10725 ^@ http://purl.uniprot.org/uniprot/C5CI97 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/521045:KOLE_RS09305 ^@ http://purl.uniprot.org/uniprot/C5CGE4 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/521045:KOLE_RS08755 ^@ http://purl.uniprot.org/uniprot/C5CFS0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/521045:KOLE_RS06855 ^@ http://purl.uniprot.org/uniprot/C5CDQ2 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/521045:KOLE_RS08020 ^@ http://purl.uniprot.org/uniprot/C5CF12 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/521045:KOLE_RS05315 ^@ http://purl.uniprot.org/uniprot/C5CHJ7 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/521045:KOLE_RS05155 ^@ http://purl.uniprot.org/uniprot/C5CHH1 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/521045:KOLE_RS08985 ^@ http://purl.uniprot.org/uniprot/C5CFW7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS09510 ^@ http://purl.uniprot.org/uniprot/C5CGI2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell inner membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/521045:KOLE_RS01925 ^@ http://purl.uniprot.org/uniprot/C5CDT2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/521045:KOLE_RS07215 ^@ http://purl.uniprot.org/uniprot/C5CE25 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/521045:KOLE_RS02595 ^@ http://purl.uniprot.org/uniprot/C5CEI6 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/521045:KOLE_RS04795 ^@ http://purl.uniprot.org/uniprot/C5CGZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. GalK subfamily.|||Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS07330 ^@ http://purl.uniprot.org/uniprot/C5CEA9 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. http://togogenome.org/gene/521045:KOLE_RS03825 ^@ http://purl.uniprot.org/uniprot/C5CG24 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS00475 ^@ http://purl.uniprot.org/uniprot/C5CHW5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/521045:KOLE_RS07500 ^@ http://purl.uniprot.org/uniprot/C5CEE0 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily. http://togogenome.org/gene/521045:KOLE_RS07585 ^@ http://purl.uniprot.org/uniprot/C5CE16 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/521045:KOLE_RS11710 ^@ http://purl.uniprot.org/uniprot/C5CIU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS10890 ^@ http://purl.uniprot.org/uniprot/C5CIP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.|||Cytoplasm|||In the C-terminal section; belongs to the helicase family. RecG subfamily.|||In the N-terminal section; belongs to the UvrB family. http://togogenome.org/gene/521045:KOLE_RS09690 ^@ http://purl.uniprot.org/uniprot/C5CGT0 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/521045:KOLE_RS06700 ^@ http://purl.uniprot.org/uniprot/C5CDL9 ^@ Similarity ^@ In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family. http://togogenome.org/gene/521045:KOLE_RS06915 ^@ http://purl.uniprot.org/uniprot/C5CDR2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. MraY subfamily.|||Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.|||Cell inner membrane http://togogenome.org/gene/521045:KOLE_RS11005 ^@ http://purl.uniprot.org/uniprot/C5CD28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/521045:KOLE_RS06740 ^@ http://purl.uniprot.org/uniprot/C5CDM7 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/521045:KOLE_RS02325 ^@ http://purl.uniprot.org/uniprot/C5CE69 ^@ Function|||Similarity ^@ Belongs to the CobU/CobP family.|||Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. http://togogenome.org/gene/521045:KOLE_RS04555 ^@ http://purl.uniprot.org/uniprot/C5CGM9 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/521045:KOLE_RS05940 ^@ http://purl.uniprot.org/uniprot/C5CIL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS03035 ^@ http://purl.uniprot.org/uniprot/C5CEY4 ^@ Similarity ^@ Belongs to the UPF0597 family. http://togogenome.org/gene/521045:KOLE_RS02570 ^@ http://purl.uniprot.org/uniprot/C5CEI1 ^@ Cofactor|||Similarity ^@ Belongs to the iron-containing alcohol dehydrogenase family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/521045:KOLE_RS02590 ^@ http://purl.uniprot.org/uniprot/C5CEI5 ^@ Similarity ^@ Belongs to the aspartate/glutamate racemases family. http://togogenome.org/gene/521045:KOLE_RS10685 ^@ http://purl.uniprot.org/uniprot/C5CI89 ^@ Similarity ^@ Belongs to the formate--tetrahydrofolate ligase family. http://togogenome.org/gene/521045:KOLE_RS01050 ^@ http://purl.uniprot.org/uniprot/C5CIU2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS09475 ^@ http://purl.uniprot.org/uniprot/C5CGH5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/521045:KOLE_RS09835 ^@ http://purl.uniprot.org/uniprot/C5CGV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS01590 ^@ http://purl.uniprot.org/uniprot/C5CD94 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6. http://togogenome.org/gene/521045:KOLE_RS07295 ^@ http://purl.uniprot.org/uniprot/C5CE40 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/521045:KOLE_RS07255 ^@ http://purl.uniprot.org/uniprot/C5CE33 ^@ Domain|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/521045:KOLE_RS00025 ^@ http://purl.uniprot.org/uniprot/C5CH94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS01980 ^@ http://purl.uniprot.org/uniprot/C5CDU2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.|||Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.|||Homotetramer composed of a dimer of dimers. http://togogenome.org/gene/521045:KOLE_RS09790 ^@ http://purl.uniprot.org/uniprot/C5CGV0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/521045:KOLE_RS10930 ^@ http://purl.uniprot.org/uniprot/C5CIQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetokinase family.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS01125 ^@ http://purl.uniprot.org/uniprot/C5CIV7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase delta chain family.|||Cell inner membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction. http://togogenome.org/gene/521045:KOLE_RS06905 ^@ http://purl.uniprot.org/uniprot/C5CDR0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS04260 ^@ http://purl.uniprot.org/uniprot/C5CGB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS00205 ^@ http://purl.uniprot.org/uniprot/C5CHD0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/521045:KOLE_RS03455 ^@ http://purl.uniprot.org/uniprot/C5CFH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS03065 ^@ http://purl.uniprot.org/uniprot/C5CEZ0 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/521045:KOLE_RS09595 ^@ http://purl.uniprot.org/uniprot/C5CGR1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/521045:KOLE_RS10710 ^@ http://purl.uniprot.org/uniprot/C5CI94 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. http://togogenome.org/gene/521045:KOLE_RS05995 ^@ http://purl.uniprot.org/uniprot/C5CIM8 ^@ Similarity ^@ Belongs to the peptidase S9C family. http://togogenome.org/gene/521045:KOLE_RS04810 ^@ http://purl.uniprot.org/uniprot/C5CGZ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS01385 ^@ http://purl.uniprot.org/uniprot/C5CD53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell inner membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/521045:KOLE_RS09495 ^@ http://purl.uniprot.org/uniprot/C5CGH9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/521045:KOLE_RS01630 ^@ http://purl.uniprot.org/uniprot/C5CDG2 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/521045:KOLE_RS06990 ^@ http://purl.uniprot.org/uniprot/C5CDY7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MnmG family.|||Cytoplasm|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. http://togogenome.org/gene/521045:KOLE_RS04790 ^@ http://purl.uniprot.org/uniprot/C5CGZ3 ^@ Cofactor|||Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/521045:KOLE_RS03505 ^@ http://purl.uniprot.org/uniprot/C5CFI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS08255 ^@ http://purl.uniprot.org/uniprot/C5CFB8 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/521045:KOLE_RS06355 ^@ http://purl.uniprot.org/uniprot/C5CJ42 ^@ Similarity ^@ Belongs to the DNA polymerase type-Y family. http://togogenome.org/gene/521045:KOLE_RS08120 ^@ http://purl.uniprot.org/uniprot/C5CF36 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Cell inner membrane|||Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/521045:KOLE_RS08380 ^@ http://purl.uniprot.org/uniprot/C5CFD7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/521045:KOLE_RS00340 ^@ http://purl.uniprot.org/uniprot/C5CHT5 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/521045:KOLE_RS07125 ^@ http://purl.uniprot.org/uniprot/C5CE10 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate 5-kinase family.|||Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS07870 ^@ http://purl.uniprot.org/uniprot/C5CES2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/521045:KOLE_RS02985 ^@ http://purl.uniprot.org/uniprot/C5CEX0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/521045:KOLE_RS07705 ^@ http://purl.uniprot.org/uniprot/C5CEN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/521045:KOLE_RS05850 ^@ http://purl.uniprot.org/uniprot/C5CIJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS00010 ^@ http://purl.uniprot.org/uniprot/C5CH91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DnaA family.|||Cytoplasm|||Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. http://togogenome.org/gene/521045:KOLE_RS05245 ^@ http://purl.uniprot.org/uniprot/C5CHI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS09085 ^@ http://purl.uniprot.org/uniprot/C5CFY6 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/521045:KOLE_RS09300 ^@ http://purl.uniprot.org/uniprot/C5CGE3 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/521045:KOLE_RS09430 ^@ http://purl.uniprot.org/uniprot/C5CGG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Membrane http://togogenome.org/gene/521045:KOLE_RS09230 ^@ http://purl.uniprot.org/uniprot/C5CFS5 ^@ Cofactor ^@ Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/521045:KOLE_RS10745 ^@ http://purl.uniprot.org/uniprot/C5CIA1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.|||Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.|||Homodimer. http://togogenome.org/gene/521045:KOLE_RS04310 ^@ http://purl.uniprot.org/uniprot/C5CGC3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/521045:KOLE_RS07030 ^@ http://purl.uniprot.org/uniprot/C5CDZ3 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/521045:KOLE_RS10125 ^@ http://purl.uniprot.org/uniprot/C5CH81 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/521045:KOLE_RS01525 ^@ http://purl.uniprot.org/uniprot/C5CD81 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/521045:KOLE_RS06200 ^@ http://purl.uniprot.org/uniprot/C5CJ10 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/521045:KOLE_RS08365 ^@ http://purl.uniprot.org/uniprot/C5CFD4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.|||Belongs to the ClpX chaperone family. HslU subfamily.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS06160 ^@ http://purl.uniprot.org/uniprot/C5CJ02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS00885 ^@ http://purl.uniprot.org/uniprot/C5CIG3 ^@ Similarity ^@ Belongs to the bacterial sugar transferase family. http://togogenome.org/gene/521045:KOLE_RS01755 ^@ http://purl.uniprot.org/uniprot/C5CDI1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/521045:KOLE_RS05855 ^@ http://purl.uniprot.org/uniprot/C5CIJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS10400 ^@ http://purl.uniprot.org/uniprot/C5CHR0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS07765 ^@ http://purl.uniprot.org/uniprot/C5CEQ1 ^@ Similarity ^@ Belongs to the XseB family. http://togogenome.org/gene/521045:KOLE_RS04360 ^@ http://purl.uniprot.org/uniprot/C5CGJ2 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/521045:KOLE_RS07315 ^@ http://purl.uniprot.org/uniprot/C5CEA6 ^@ Function|||Similarity ^@ Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). http://togogenome.org/gene/521045:KOLE_RS09485 ^@ http://purl.uniprot.org/uniprot/C5CGH7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/521045:KOLE_RS05650 ^@ http://purl.uniprot.org/uniprot/C5CI44 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.|||Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/521045:KOLE_RS08175 ^@ http://purl.uniprot.org/uniprot/C5CF45 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. N-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/521045:KOLE_RS10555 ^@ http://purl.uniprot.org/uniprot/C5CI64 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/521045:KOLE_RS09550 ^@ http://purl.uniprot.org/uniprot/C5CGJ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/521045:KOLE_RS10165 ^@ http://purl.uniprot.org/uniprot/C5CH88 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS05725 ^@ http://purl.uniprot.org/uniprot/C5CIH6 ^@ Function|||Similarity ^@ Belongs to the transposase mutator family.|||Required for the transposition of the insertion element. http://togogenome.org/gene/521045:KOLE_RS10965 ^@ http://purl.uniprot.org/uniprot/C5CIR4 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/521045:KOLE_RS03285 ^@ http://purl.uniprot.org/uniprot/C5CF87 ^@ Similarity ^@ Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family. http://togogenome.org/gene/521045:KOLE_RS09435 ^@ http://purl.uniprot.org/uniprot/C5CGG7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IspF family.|||Binds 1 divalent metal cation per subunit.|||Homotrimer.|||Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). http://togogenome.org/gene/521045:KOLE_RS04495 ^@ http://purl.uniprot.org/uniprot/C5CGL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-C family. PolC subfamily.|||Cytoplasm|||Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/521045:KOLE_RS05120 ^@ http://purl.uniprot.org/uniprot/C5CHG4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/521045:KOLE_RS01315 ^@ http://purl.uniprot.org/uniprot/C5CD39 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/521045:KOLE_RS02740 ^@ http://purl.uniprot.org/uniprot/C5CEL3 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/521045:KOLE_RS04345 ^@ http://purl.uniprot.org/uniprot/C5CGD0 ^@ Function ^@ Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. http://togogenome.org/gene/521045:KOLE_RS04525 ^@ http://purl.uniprot.org/uniprot/C5CGM3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NDK family.|||Cytoplasm|||Homotetramer.|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/521045:KOLE_RS00620 ^@ http://purl.uniprot.org/uniprot/C5CHV2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS07610 ^@ http://purl.uniprot.org/uniprot/C5CEG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS01095 ^@ http://purl.uniprot.org/uniprot/C5CIV1 ^@ Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||GTPase that plays an essential role in the late steps of ribosome biogenesis. http://togogenome.org/gene/521045:KOLE_RS09295 ^@ http://purl.uniprot.org/uniprot/C5CGE2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/521045:KOLE_RS04990 ^@ http://purl.uniprot.org/uniprot/C5CH32 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/521045:KOLE_RS03595 ^@ http://purl.uniprot.org/uniprot/C5CFK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS05780 ^@ http://purl.uniprot.org/uniprot/C5CII6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS10025 ^@ http://purl.uniprot.org/uniprot/C5CH61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS01430 ^@ http://purl.uniprot.org/uniprot/C5CD62 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Hfq family.|||Homohexamer.|||RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. http://togogenome.org/gene/521045:KOLE_RS10955 ^@ http://purl.uniprot.org/uniprot/C5CIR2 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/521045:KOLE_RS01895 ^@ http://purl.uniprot.org/uniprot/C5CDS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.|||Cell inner membrane|||Membrane|||Probable transporter of a GTP-driven Fe(2+) uptake system. http://togogenome.org/gene/521045:KOLE_RS07735 ^@ http://purl.uniprot.org/uniprot/C5CEP5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/521045:KOLE_RS06520 ^@ http://purl.uniprot.org/uniprot/C5CDC5 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/521045:KOLE_RS04215 ^@ http://purl.uniprot.org/uniprot/C5CGA4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS09500 ^@ http://purl.uniprot.org/uniprot/C5CGI0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/521045:KOLE_RS10285 ^@ http://purl.uniprot.org/uniprot/C5CHN8 ^@ Similarity ^@ Belongs to the dihydrofolate reductase family. http://togogenome.org/gene/521045:KOLE_RS10895 ^@ http://purl.uniprot.org/uniprot/C5CIQ0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.|||Binds 1 potassium ion per subunit.|||Cytoplasm|||Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS00685 ^@ http://purl.uniprot.org/uniprot/C5CIC3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS01860 ^@ http://purl.uniprot.org/uniprot/C5CDK3 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/521045:KOLE_RS01650 ^@ http://purl.uniprot.org/uniprot/C5CDG6 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/521045:KOLE_RS07245 ^@ http://purl.uniprot.org/uniprot/C5CE31 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/521045:KOLE_RS08575 ^@ http://purl.uniprot.org/uniprot/C5CFH6 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.|||Cytoplasm|||Homodimer or homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Non-allosteric. http://togogenome.org/gene/521045:KOLE_RS06600 ^@ http://purl.uniprot.org/uniprot/C5CDE3 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/521045:KOLE_RS03265 ^@ http://purl.uniprot.org/uniprot/C5CF83 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS07690 ^@ http://purl.uniprot.org/uniprot/C5CEN6 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/521045:KOLE_RS07350 ^@ http://purl.uniprot.org/uniprot/C5CEB3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/521045:KOLE_RS01570 ^@ http://purl.uniprot.org/uniprot/C5CD90 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/521045:KOLE_RS08685 ^@ http://purl.uniprot.org/uniprot/C5CFQ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase RlmH family.|||Cytoplasm|||Homodimer.|||Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. http://togogenome.org/gene/521045:KOLE_RS05130 ^@ http://purl.uniprot.org/uniprot/C5CHG6 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.|||Cytoplasm|||Homodimer.|||Non-allosteric. http://togogenome.org/gene/521045:KOLE_RS08825 ^@ http://purl.uniprot.org/uniprot/C5CFT8 ^@ Cofactor|||Similarity ^@ Belongs to the mandelate racemase/muconate lactonizing enzyme family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/521045:KOLE_RS08010 ^@ http://purl.uniprot.org/uniprot/C5CF10 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. IspE subfamily.|||Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. http://togogenome.org/gene/521045:KOLE_RS01245 ^@ http://purl.uniprot.org/uniprot/C5CIS7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.|||Binds 1 zinc ion per subunit.|||Binds the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/521045:KOLE_RS08115 ^@ http://purl.uniprot.org/uniprot/C5CF35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YajC family.|||Membrane http://togogenome.org/gene/521045:KOLE_RS10410 ^@ http://purl.uniprot.org/uniprot/C5CHR2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS02725 ^@ http://purl.uniprot.org/uniprot/C5CEL0 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.|||Belongs to the peptidase S16 family.|||By heat shock.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity. http://togogenome.org/gene/521045:KOLE_RS07170 ^@ http://purl.uniprot.org/uniprot/C5CE17 ^@ Similarity ^@ Belongs to the transposase IS21/IS408/IS1162 family. http://togogenome.org/gene/521045:KOLE_RS00500 ^@ http://purl.uniprot.org/uniprot/C5CHX0 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. http://togogenome.org/gene/521045:KOLE_RS00490 ^@ http://purl.uniprot.org/uniprot/C5CHW8 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.|||Cytoplasm|||Heterotetramer of two alpha and two beta chains.|||Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway. http://togogenome.org/gene/521045:KOLE_RS09090 ^@ http://purl.uniprot.org/uniprot/C5CFY7 ^@ Similarity ^@ Belongs to the transposase IS21/IS408/IS1162 family. http://togogenome.org/gene/521045:KOLE_RS08265 ^@ http://purl.uniprot.org/uniprot/C5CFC0 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/521045:KOLE_RS04395 ^@ http://purl.uniprot.org/uniprot/C5CGJ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.|||Homodimer.|||Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. http://togogenome.org/gene/521045:KOLE_RS08640 ^@ http://purl.uniprot.org/uniprot/C5CFP8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell inner membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Membrane|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/521045:KOLE_RS07545 ^@ http://purl.uniprot.org/uniprot/C5CEE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Membrane http://togogenome.org/gene/521045:KOLE_RS09505 ^@ http://purl.uniprot.org/uniprot/C5CGI1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.|||Cytoplasm|||Monomer. http://togogenome.org/gene/521045:KOLE_RS05760 ^@ http://purl.uniprot.org/uniprot/C5CII2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/521045:KOLE_RS11715 ^@ http://purl.uniprot.org/uniprot/C5CIU9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspH family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. http://togogenome.org/gene/521045:KOLE_RS09360 ^@ http://purl.uniprot.org/uniprot/C5CGF3 ^@ Function|||Similarity ^@ Belongs to the NAD-dependent DNA ligase family. LigA subfamily.|||DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. http://togogenome.org/gene/521045:KOLE_RS04405 ^@ http://purl.uniprot.org/uniprot/C5CGK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS00355 ^@ http://purl.uniprot.org/uniprot/C5CHT8 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/521045:KOLE_RS10850 ^@ http://purl.uniprot.org/uniprot/C5CIP1 ^@ Cofactor|||Similarity ^@ Belongs to the Fur family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/521045:KOLE_RS04860 ^@ http://purl.uniprot.org/uniprot/C5CH06 ^@ Similarity ^@ Belongs to the radical SAM superfamily. KamA family. http://togogenome.org/gene/521045:KOLE_RS09865 ^@ http://purl.uniprot.org/uniprot/C5CGW5 ^@ Similarity ^@ Belongs to the Skp family. http://togogenome.org/gene/521045:KOLE_RS02095 ^@ http://purl.uniprot.org/uniprot/C5CDW5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/521045:KOLE_RS08125 ^@ http://purl.uniprot.org/uniprot/C5CF37 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecF subfamily.|||Cell inner membrane|||Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/521045:KOLE_RS04910 ^@ http://purl.uniprot.org/uniprot/C5CH16 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/521045:KOLE_RS02175 ^@ http://purl.uniprot.org/uniprot/C5CDY0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS02295 ^@ http://purl.uniprot.org/uniprot/C5CE63 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the urocanase family.|||Binds 1 NAD(+) per subunit.|||Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS07375 ^@ http://purl.uniprot.org/uniprot/C5CEB8 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/521045:KOLE_RS05610 ^@ http://purl.uniprot.org/uniprot/C5CI36 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/521045:KOLE_RS06945 ^@ http://purl.uniprot.org/uniprot/C5CDR8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS05705 ^@ http://purl.uniprot.org/uniprot/C5CHZ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/521045:KOLE_RS07970 ^@ http://purl.uniprot.org/uniprot/C5CF02 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS06225 ^@ http://purl.uniprot.org/uniprot/C5CJ15 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/521045:KOLE_RS05630 ^@ http://purl.uniprot.org/uniprot/C5CI40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.|||Membrane http://togogenome.org/gene/521045:KOLE_RS05250 ^@ http://purl.uniprot.org/uniprot/C5CHI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS07120 ^@ http://purl.uniprot.org/uniprot/C5CE09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyl phosphate reductase family.|||Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS05070 ^@ http://purl.uniprot.org/uniprot/C5CHF6 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/521045:KOLE_RS03060 ^@ http://purl.uniprot.org/uniprot/C5CEY9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbsD / FucU family. RbsD subfamily.|||Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.|||Cytoplasm|||Homodecamer. http://togogenome.org/gene/521045:KOLE_RS02855 ^@ http://purl.uniprot.org/uniprot/C5CEU6 ^@ Similarity ^@ Belongs to the peptidase A31 family. http://togogenome.org/gene/521045:KOLE_RS10840 ^@ http://purl.uniprot.org/uniprot/C5CIN9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/521045:KOLE_RS06315 ^@ http://purl.uniprot.org/uniprot/C5CJ34 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS01345 ^@ http://purl.uniprot.org/uniprot/C5CD45 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/521045:KOLE_RS10405 ^@ http://purl.uniprot.org/uniprot/C5CHR1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS07655 ^@ http://purl.uniprot.org/uniprot/C5CEM9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS08780 ^@ http://purl.uniprot.org/uniprot/C5CFS9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Monomer.|||The C-terminal coiled-coil domain is crucial for aminoacylation activity.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/521045:KOLE_RS01760 ^@ http://purl.uniprot.org/uniprot/C5CDI2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/521045:KOLE_RS04130 ^@ http://purl.uniprot.org/uniprot/C5CG86 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. http://togogenome.org/gene/521045:KOLE_RS00550 ^@ http://purl.uniprot.org/uniprot/C5CHY0 ^@ Similarity ^@ Belongs to the diaminopimelate epimerase family. http://togogenome.org/gene/521045:KOLE_RS01875 ^@ http://purl.uniprot.org/uniprot/C5CDK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MgtC/SapB family.|||Membrane http://togogenome.org/gene/521045:KOLE_RS00525 ^@ http://purl.uniprot.org/uniprot/C5CHX5 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/521045:KOLE_RS08300 ^@ http://purl.uniprot.org/uniprot/B5M6N5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyribonucleotide nucleotidyltransferase family.|||Cytoplasm|||Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. http://togogenome.org/gene/521045:KOLE_RS08350 ^@ http://purl.uniprot.org/uniprot/C5CFD1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Cytoplasm|||Homodimer.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/521045:KOLE_RS08180 ^@ http://purl.uniprot.org/uniprot/C5CF46 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/521045:KOLE_RS09815 ^@ http://purl.uniprot.org/uniprot/C5CGV5 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RlmN family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.|||Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. http://togogenome.org/gene/521045:KOLE_RS08295 ^@ http://purl.uniprot.org/uniprot/B5M6N4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/521045:KOLE_RS01325 ^@ http://purl.uniprot.org/uniprot/C5CD41 ^@ Similarity ^@ Belongs to the CND3 (condensin subunit 3) family. http://togogenome.org/gene/521045:KOLE_RS04440 ^@ http://purl.uniprot.org/uniprot/C5CGK7 ^@ Function|||Similarity ^@ Belongs to the anhydro-N-acetylmuramic acid kinase family.|||Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. http://togogenome.org/gene/521045:KOLE_RS01265 ^@ http://purl.uniprot.org/uniprot/C5CD29 ^@ Similarity ^@ Belongs to the asparaginase 1 family. http://togogenome.org/gene/521045:KOLE_RS09520 ^@ http://purl.uniprot.org/uniprot/C5CGI4 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/521045:KOLE_RS08225 ^@ http://purl.uniprot.org/uniprot/B5M6M1 ^@ Similarity ^@ Belongs to the UDP-N-acetylglucosamine 2-epimerase family. http://togogenome.org/gene/521045:KOLE_RS09750 ^@ http://purl.uniprot.org/uniprot/C5CGU2 ^@ Similarity ^@ Belongs to the ComB family. http://togogenome.org/gene/521045:KOLE_RS10680 ^@ http://purl.uniprot.org/uniprot/C5CI88 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/521045:KOLE_RS07015 ^@ http://purl.uniprot.org/uniprot/C5CDZ1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the pseudouridine-5'-phosphate glycosidase family.|||Binds 1 Mn(2+) ion per subunit.|||Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.|||Homotrimer. http://togogenome.org/gene/521045:KOLE_RS03925 ^@ http://purl.uniprot.org/uniprot/C5CG47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS10575 ^@ http://purl.uniprot.org/uniprot/C5CI68 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/521045:KOLE_RS03855 ^@ http://purl.uniprot.org/uniprot/C5CG29 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS01100 ^@ http://purl.uniprot.org/uniprot/C5CIV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsY family.|||Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.|||Cell inner membrane|||Probably interacts with PlsX. http://togogenome.org/gene/521045:KOLE_RS07635 ^@ http://purl.uniprot.org/uniprot/C5CEG5 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. http://togogenome.org/gene/521045:KOLE_RS02445 ^@ http://purl.uniprot.org/uniprot/C5CE97 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 38 family. http://togogenome.org/gene/521045:KOLE_RS00835 ^@ http://purl.uniprot.org/uniprot/C5CIF3 ^@ Similarity ^@ Belongs to the BtpA family. http://togogenome.org/gene/521045:KOLE_RS07820 ^@ http://purl.uniprot.org/uniprot/C5CER2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS02060 ^@ http://purl.uniprot.org/uniprot/C5CDV8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/521045:KOLE_RS09615 ^@ http://purl.uniprot.org/uniprot/C5CGR5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/521045:KOLE_RS09975 ^@ http://purl.uniprot.org/uniprot/C5CH53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS06910 ^@ http://purl.uniprot.org/uniprot/C5CDR1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS07365 ^@ http://purl.uniprot.org/uniprot/C5CEB6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/521045:KOLE_RS01530 ^@ http://purl.uniprot.org/uniprot/C5CD82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS10810 ^@ http://purl.uniprot.org/uniprot/C5CIN3 ^@ Similarity ^@ Belongs to the desulfoferrodoxin family. http://togogenome.org/gene/521045:KOLE_RS04400 ^@ http://purl.uniprot.org/uniprot/C5CGJ9 ^@ Similarity ^@ Belongs to the peptidase S13 family. http://togogenome.org/gene/521045:KOLE_RS06330 ^@ http://purl.uniprot.org/uniprot/C5CJ37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CitM (TC 2.A.11) transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS06900 ^@ http://purl.uniprot.org/uniprot/C5CDQ9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family. MurG subfamily.|||Cell inner membrane|||Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS08565 ^@ http://purl.uniprot.org/uniprot/C5CFH4 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/521045:KOLE_RS04145 ^@ http://purl.uniprot.org/uniprot/C5CG89 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C15 family.|||Cytoplasm|||Removes 5-oxoproline from various penultimate amino acid residues except L-proline. http://togogenome.org/gene/521045:KOLE_RS03705 ^@ http://purl.uniprot.org/uniprot/C5CFM7 ^@ Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. NagA family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/521045:KOLE_RS00015 ^@ http://purl.uniprot.org/uniprot/C5CH92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS10875 ^@ http://purl.uniprot.org/uniprot/C5CIP6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/521045:KOLE_RS10075 ^@ http://purl.uniprot.org/uniprot/C5CH71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS07260 ^@ http://purl.uniprot.org/uniprot/C5CE34 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS10655 ^@ http://purl.uniprot.org/uniprot/C5CI83 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/521045:KOLE_RS01320 ^@ http://purl.uniprot.org/uniprot/C5CD40 ^@ Function|||Similarity ^@ Belongs to the RecN family.|||May be involved in recombinational repair of damaged DNA. http://togogenome.org/gene/521045:KOLE_RS08760 ^@ http://purl.uniprot.org/uniprot/C5CFS1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/521045:KOLE_RS10940 ^@ http://purl.uniprot.org/uniprot/C5CIQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetokinase family.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS04250 ^@ http://purl.uniprot.org/uniprot/C5CGB1 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/521045:KOLE_RS00095 ^@ http://purl.uniprot.org/uniprot/C5CHA8 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/521045:KOLE_RS07515 ^@ http://purl.uniprot.org/uniprot/C5CEE3 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/521045:KOLE_RS08960 ^@ http://purl.uniprot.org/uniprot/C5CFW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS07850 ^@ http://purl.uniprot.org/uniprot/C5CER8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional regulatory Rex family.|||Cytoplasm|||Homodimer.|||Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. http://togogenome.org/gene/521045:KOLE_RS08965 ^@ http://purl.uniprot.org/uniprot/C5CFW3 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/521045:KOLE_RS07805 ^@ http://purl.uniprot.org/uniprot/C5CEQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS08305 ^@ http://purl.uniprot.org/uniprot/B5M6N6 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/521045:KOLE_RS05795 ^@ http://purl.uniprot.org/uniprot/C5CII9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS01310 ^@ http://purl.uniprot.org/uniprot/C5CD38 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RnpA family.|||Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.|||RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. http://togogenome.org/gene/521045:KOLE_RS05255 ^@ http://purl.uniprot.org/uniprot/C5CHI9 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 1 family. http://togogenome.org/gene/521045:KOLE_RS08580 ^@ http://purl.uniprot.org/uniprot/C5CFF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.|||Belongs to the RNR ribonuclease family. RNase R subfamily.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS00760 ^@ http://purl.uniprot.org/uniprot/C5CID9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS10650 ^@ http://purl.uniprot.org/uniprot/C5CI82 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell inner membrane|||Cytoplasm|||Monomer. http://togogenome.org/gene/521045:KOLE_RS08765 ^@ http://purl.uniprot.org/uniprot/C5CFS2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Mg(2+) ion per subunit.|||Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.|||Cytoplasm|||Homotrimer.|||In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/521045:KOLE_RS08480 ^@ http://purl.uniprot.org/uniprot/C5CFF8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS03585 ^@ http://purl.uniprot.org/uniprot/C5CFK5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/521045:KOLE_RS10455 ^@ http://purl.uniprot.org/uniprot/C5CHS0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/521045:KOLE_RS09355 ^@ http://purl.uniprot.org/uniprot/C5CGF2 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/521045:KOLE_RS05595 ^@ http://purl.uniprot.org/uniprot/C5CI33 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS01180 ^@ http://purl.uniprot.org/uniprot/C5CIW8 ^@ Similarity ^@ Belongs to the HepT RNase toxin family. http://togogenome.org/gene/521045:KOLE_RS01040 ^@ http://purl.uniprot.org/uniprot/C5CIU0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS10395 ^@ http://purl.uniprot.org/uniprot/C5CHQ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS08995 ^@ http://purl.uniprot.org/uniprot/C5CFW9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS06720 ^@ http://purl.uniprot.org/uniprot/C5CDM4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS03240 ^@ http://purl.uniprot.org/uniprot/C5CF78 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/521045:KOLE_RS09720 ^@ http://purl.uniprot.org/uniprot/C5CGT6 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell inner membrane http://togogenome.org/gene/521045:KOLE_RS01295 ^@ http://purl.uniprot.org/uniprot/C5CD35 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable RNA chaperone. Forms a complex with KhpA which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.|||Belongs to the KhpB RNA-binding protein family.|||Cytoplasm|||Forms a complex with KhpA.|||Has an N-terminal Jag-N domain and 2 RNA-binding domains (KH and R3H). http://togogenome.org/gene/521045:KOLE_RS10385 ^@ http://purl.uniprot.org/uniprot/C5CHQ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS00535 ^@ http://purl.uniprot.org/uniprot/C5CHX7 ^@ Function|||Similarity ^@ Belongs to the transferase hexapeptide repeat family. DapH subfamily.|||Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. http://togogenome.org/gene/521045:KOLE_RS06205 ^@ http://purl.uniprot.org/uniprot/C5CJ11 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/521045:KOLE_RS03865 ^@ http://purl.uniprot.org/uniprot/C5CG31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS10155 ^@ http://purl.uniprot.org/uniprot/C5CH86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurJ/MviN family.|||Cell inner membrane|||Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.|||Membrane http://togogenome.org/gene/521045:KOLE_RS08520 ^@ http://purl.uniprot.org/uniprot/C5CFG6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).|||Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1. http://togogenome.org/gene/521045:KOLE_RS07165 ^@ http://purl.uniprot.org/uniprot/C5CE16 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/521045:KOLE_RS09600 ^@ http://purl.uniprot.org/uniprot/C5CGR2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/521045:KOLE_RS10660 ^@ http://purl.uniprot.org/uniprot/C5CI84 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/521045:KOLE_RS09450 ^@ http://purl.uniprot.org/uniprot/C5CGH0 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/521045:KOLE_RS00840 ^@ http://purl.uniprot.org/uniprot/C5CIF4 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/521045:KOLE_RS04700 ^@ http://purl.uniprot.org/uniprot/C5CGX5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS08720 ^@ http://purl.uniprot.org/uniprot/C5CFR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/521045:KOLE_RS05545 ^@ http://purl.uniprot.org/uniprot/C5CI23 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/521045:KOLE_RS09605 ^@ http://purl.uniprot.org/uniprot/C5CGR3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/521045:KOLE_RS04350 ^@ http://purl.uniprot.org/uniprot/C5CGD1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sirtuin family. Class U subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. http://togogenome.org/gene/521045:KOLE_RS02365 ^@ http://purl.uniprot.org/uniprot/C5CE77 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS08905 ^@ http://purl.uniprot.org/uniprot/C5CFV1 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/521045:KOLE_RS04065 ^@ http://purl.uniprot.org/uniprot/C5CG73 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/521045:KOLE_RS08035 ^@ http://purl.uniprot.org/uniprot/C5CF15 ^@ Similarity ^@ Belongs to the SAM hydrolase / SAM-dependent halogenase family. http://togogenome.org/gene/521045:KOLE_RS09830 ^@ http://purl.uniprot.org/uniprot/C5CGV8 ^@ Cofactor|||Similarity ^@ Belongs to the PTPS family. QueD subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/521045:KOLE_RS06805 ^@ http://purl.uniprot.org/uniprot/C5CDP1 ^@ Cofactor|||Similarity ^@ Belongs to the alkaline phosphatase family.|||Binds 1 Mg(2+) ion.|||Binds 2 Zn(2+) ions. http://togogenome.org/gene/521045:KOLE_RS03275 ^@ http://purl.uniprot.org/uniprot/C5CF85 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M38 family.|||Binds 2 Zn(2+) ions per subunit.|||Carboxylation allows a single lysine to coordinate two zinc ions.|||Catalyzes the hydrolytic cleavage of a subset of L-isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS09850 ^@ http://purl.uniprot.org/uniprot/C5CGW2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/521045:KOLE_RS06895 ^@ http://purl.uniprot.org/uniprot/C5CDQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS09575 ^@ http://purl.uniprot.org/uniprot/C5CGQ7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/521045:KOLE_RS00970 ^@ http://purl.uniprot.org/uniprot/C5CIS3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGMT family.|||Cytoplasm|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.|||This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles. http://togogenome.org/gene/521045:KOLE_RS08370 ^@ http://purl.uniprot.org/uniprot/C5CFD5 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||Allosterically activated by HslU binding.|||Belongs to the peptidase T1B family. HslV subfamily.|||Cytoplasm|||Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. http://togogenome.org/gene/521045:KOLE_RS00450 ^@ http://purl.uniprot.org/uniprot/C5CHW0 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/521045:KOLE_RS07200 ^@ http://purl.uniprot.org/uniprot/C5CE22 ^@ Similarity ^@ Belongs to the carbamate kinase family. http://togogenome.org/gene/521045:KOLE_RS07490 ^@ http://purl.uniprot.org/uniprot/C5CED8 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/521045:KOLE_RS02920 ^@ http://purl.uniprot.org/uniprot/C5CEV6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS09400 ^@ http://purl.uniprot.org/uniprot/C5CGG1 ^@ Similarity ^@ Belongs to the bacterial secretin family. http://togogenome.org/gene/521045:KOLE_RS10465 ^@ http://purl.uniprot.org/uniprot/C5CHS3 ^@ Similarity ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. http://togogenome.org/gene/521045:KOLE_RS08355 ^@ http://purl.uniprot.org/uniprot/C5CFD2 ^@ Cofactor ^@ Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. http://togogenome.org/gene/521045:KOLE_RS08095 ^@ http://purl.uniprot.org/uniprot/C5CF31 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS02875 ^@ http://purl.uniprot.org/uniprot/C5CEV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS04600 ^@ http://purl.uniprot.org/uniprot/C5CGP1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspG family.|||Binds 1 [4Fe-4S] cluster.|||Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. http://togogenome.org/gene/521045:KOLE_RS09460 ^@ http://purl.uniprot.org/uniprot/C5CGH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transaldolase family. Type 3B subfamily.|||Cytoplasm|||Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. http://togogenome.org/gene/521045:KOLE_RS00745 ^@ http://purl.uniprot.org/uniprot/C5CID6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferritin family. Prokaryotic subfamily.|||Cytoplasm|||Iron-storage protein. http://togogenome.org/gene/521045:KOLE_RS08185 ^@ http://purl.uniprot.org/uniprot/C5CF47 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvT family.|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/521045:KOLE_RS10630 ^@ http://purl.uniprot.org/uniprot/C5CI78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/521045:KOLE_RS07475 ^@ http://purl.uniprot.org/uniprot/C5CED5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS03535 ^@ http://purl.uniprot.org/uniprot/C5CFJ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS05295 ^@ http://purl.uniprot.org/uniprot/C5CHJ7 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/521045:KOLE_RS08750 ^@ http://purl.uniprot.org/uniprot/C5CFR9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/521045:KOLE_RS03000 ^@ http://purl.uniprot.org/uniprot/C5CEX3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/521045:KOLE_RS05755 ^@ http://purl.uniprot.org/uniprot/C5CII1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell inner membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS04115 ^@ http://purl.uniprot.org/uniprot/C5CG83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS09535 ^@ http://purl.uniprot.org/uniprot/C5CGI7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/521045:KOLE_RS07425 ^@ http://purl.uniprot.org/uniprot/C5CEC7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS09795 ^@ http://purl.uniprot.org/uniprot/C5CGV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Lgt family.|||Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.|||Cell inner membrane http://togogenome.org/gene/521045:KOLE_RS00640 ^@ http://purl.uniprot.org/uniprot/C5CIB5 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 3 family. http://togogenome.org/gene/521045:KOLE_RS00770 ^@ http://purl.uniprot.org/uniprot/C5CIE1 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 9 family. http://togogenome.org/gene/521045:KOLE_RS04570 ^@ http://purl.uniprot.org/uniprot/C5CGN2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RnfG family.|||Cell inner membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/521045:KOLE_RS09345 ^@ http://purl.uniprot.org/uniprot/C5CGF0 ^@ Similarity ^@ Belongs to the RemA family. http://togogenome.org/gene/521045:KOLE_RS01670 ^@ http://purl.uniprot.org/uniprot/C5CDH0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrC family.|||Cytoplasm|||Interacts with UvrB in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. http://togogenome.org/gene/521045:KOLE_RS09260 ^@ http://purl.uniprot.org/uniprot/C5CGD5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS07130 ^@ http://purl.uniprot.org/uniprot/C5CE11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS02635 ^@ http://purl.uniprot.org/uniprot/C5CEJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/521045:KOLE_RS09710 ^@ http://purl.uniprot.org/uniprot/C5CGT4 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.|||Synthesizes alpha-1,4-glucan chains using ADP-glucose. http://togogenome.org/gene/521045:KOLE_RS05060 ^@ http://purl.uniprot.org/uniprot/C5CHF4 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/521045:KOLE_RS09665 ^@ http://purl.uniprot.org/uniprot/C5CGS5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell inner membrane|||Cytoplasm|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/521045:KOLE_RS04545 ^@ http://purl.uniprot.org/uniprot/C5CGM7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.|||Homotetramer.|||Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. http://togogenome.org/gene/521045:KOLE_RS02730 ^@ http://purl.uniprot.org/uniprot/C5CEL1 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/521045:KOLE_RS08650 ^@ http://purl.uniprot.org/uniprot/C5CFQ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family.|||Homotrimer.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/521045:KOLE_RS09540 ^@ http://purl.uniprot.org/uniprot/C5CGI8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/521045:KOLE_RS08680 ^@ http://purl.uniprot.org/uniprot/C5CFQ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS00235 ^@ http://purl.uniprot.org/uniprot/C5CHD3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS00615 ^@ http://purl.uniprot.org/uniprot/C5CHZ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS01425 ^@ http://purl.uniprot.org/uniprot/C5CD61 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).|||Monomer. http://togogenome.org/gene/521045:KOLE_RS05910 ^@ http://purl.uniprot.org/uniprot/C5CIL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS09620 ^@ http://purl.uniprot.org/uniprot/C5CGR6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/521045:KOLE_RS03615 ^@ http://purl.uniprot.org/uniprot/C5CFL1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 130 family. http://togogenome.org/gene/521045:KOLE_RS07455 ^@ http://purl.uniprot.org/uniprot/C5CED3 ^@ Similarity ^@ Belongs to the RecJ family. http://togogenome.org/gene/521045:KOLE_RS09315 ^@ http://purl.uniprot.org/uniprot/C5CGE6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/521045:KOLE_RS10195 ^@ http://purl.uniprot.org/uniprot/C5CHM1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YbaB/EbfC family.|||Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.|||Homodimer.|||nucleoid http://togogenome.org/gene/521045:KOLE_RS06825 ^@ http://purl.uniprot.org/uniprot/C5CDP6 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/521045:KOLE_RS03610 ^@ http://purl.uniprot.org/uniprot/C5CFL0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 130 family. http://togogenome.org/gene/521045:KOLE_RS06155 ^@ http://purl.uniprot.org/uniprot/C5CJ01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS01075 ^@ http://purl.uniprot.org/uniprot/C5CIU7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.|||Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS06960 ^@ http://purl.uniprot.org/uniprot/C5CDS1 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/521045:KOLE_RS00940 ^@ http://purl.uniprot.org/uniprot/C5CIR7 ^@ Similarity ^@ Belongs to the complex I 51 kDa subunit family. http://togogenome.org/gene/521045:KOLE_RS01155 ^@ http://purl.uniprot.org/uniprot/C5CIW2 ^@ Function|||Similarity ^@ Belongs to the DNA polymerase type-A family.|||In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. http://togogenome.org/gene/521045:KOLE_RS07695 ^@ http://purl.uniprot.org/uniprot/C5CEN7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS05235 ^@ http://purl.uniprot.org/uniprot/C5CHI5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/521045:KOLE_RS08850 ^@ http://purl.uniprot.org/uniprot/C5CFU0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A monovalent cation. Ammonium or potassium.|||Belongs to the type III pantothenate kinase family.|||Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/521045:KOLE_RS01765 ^@ http://purl.uniprot.org/uniprot/C5CDI3 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the DnaG primase family.|||Binds 1 zinc ion per monomer.|||Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.|||Monomer. Interacts with DnaB.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/521045:KOLE_RS09570 ^@ http://purl.uniprot.org/uniprot/C5CGQ6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/521045:KOLE_RS09565 ^@ http://purl.uniprot.org/uniprot/C5CGQ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/521045:KOLE_RS08990 ^@ http://purl.uniprot.org/uniprot/C5CFW8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS10370 ^@ http://purl.uniprot.org/uniprot/C5CHQ4 ^@ Similarity ^@ Belongs to the complex I 49 kDa subunit family. http://togogenome.org/gene/521045:KOLE_RS09870 ^@ http://purl.uniprot.org/uniprot/C5CGW6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.|||An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.|||Belongs to the DTD family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/521045:KOLE_RS00060 ^@ http://purl.uniprot.org/uniprot/C5CHA1 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/521045:KOLE_RS06265 ^@ http://purl.uniprot.org/uniprot/C5CJ23 ^@ Cofactor ^@ Binds 2 irons ions per subunit via 4 cysteine residues per iron. http://togogenome.org/gene/521045:KOLE_RS01920 ^@ http://purl.uniprot.org/uniprot/C5CDT1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS07710 ^@ http://purl.uniprot.org/uniprot/C5CEP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RimP family.|||Cytoplasm|||Required for maturation of 30S ribosomal subunits. http://togogenome.org/gene/521045:KOLE_RS03280 ^@ http://purl.uniprot.org/uniprot/C5CF86 ^@ Similarity ^@ Belongs to the FBPase class 2 family. http://togogenome.org/gene/521045:KOLE_RS04775 ^@ http://purl.uniprot.org/uniprot/C5CGZ0 ^@ Similarity ^@ Belongs to the FldB/FldC dehydratase alpha/beta subunit family. http://togogenome.org/gene/521045:KOLE_RS09785 ^@ http://purl.uniprot.org/uniprot/C5CGU9 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/521045:KOLE_RS00555 ^@ http://purl.uniprot.org/uniprot/C5CHY1 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/521045:KOLE_RS00515 ^@ http://purl.uniprot.org/uniprot/C5CHX3 ^@ Function|||Similarity ^@ Belongs to the transposase mutator family.|||Required for the transposition of the insertion element. http://togogenome.org/gene/521045:KOLE_RS09480 ^@ http://purl.uniprot.org/uniprot/C5CGH6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/521045:KOLE_RS07815 ^@ http://purl.uniprot.org/uniprot/C5CER1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS09805 ^@ http://purl.uniprot.org/uniprot/C5CGV3 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit.|||Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS07985 ^@ http://purl.uniprot.org/uniprot/C5CF05 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/521045:KOLE_RS10865 ^@ http://purl.uniprot.org/uniprot/C5CIP4 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/521045:KOLE_RS07335 ^@ http://purl.uniprot.org/uniprot/C5CEB0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 57 family. http://togogenome.org/gene/521045:KOLE_RS09170 ^@ http://purl.uniprot.org/uniprot/C5CG04 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/521045:KOLE_RS00315 ^@ http://purl.uniprot.org/uniprot/C5CHT0 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/521045:KOLE_RS10550 ^@ http://purl.uniprot.org/uniprot/C5CI63 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. http://togogenome.org/gene/521045:KOLE_RS09875 ^@ http://purl.uniprot.org/uniprot/C5CGW7 ^@ Function|||Similarity ^@ Belongs to the relA/spoT family.|||In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. http://togogenome.org/gene/521045:KOLE_RS09440 ^@ http://purl.uniprot.org/uniprot/C5CGG8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA. http://togogenome.org/gene/521045:KOLE_RS09395 ^@ http://purl.uniprot.org/uniprot/C5CGG0 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/521045:KOLE_RS08955 ^@ http://purl.uniprot.org/uniprot/C5CFW1 ^@ Similarity ^@ Belongs to the CinA family. http://togogenome.org/gene/521045:KOLE_RS04430 ^@ http://purl.uniprot.org/uniprot/C5CGK5 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.|||Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.|||Homodimer.|||Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. http://togogenome.org/gene/521045:KOLE_RS01455 ^@ http://purl.uniprot.org/uniprot/C5CD67 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/521045:KOLE_RS07750 ^@ http://purl.uniprot.org/uniprot/C5CEP8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Iojap/RsfS family.|||Cytoplasm|||Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.|||Interacts with ribosomal protein uL14 (rplN). http://togogenome.org/gene/521045:KOLE_RS11025 ^@ http://purl.uniprot.org/uniprot/C5CEA1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS02715 ^@ http://purl.uniprot.org/uniprot/C5CEK8 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/521045:KOLE_RS09610 ^@ http://purl.uniprot.org/uniprot/C5CGR4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/521045:KOLE_RS03355 ^@ http://purl.uniprot.org/uniprot/C5CFA0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/521045:KOLE_RS01805 ^@ http://purl.uniprot.org/uniprot/C5CDJ2 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/521045:KOLE_RS07300 ^@ http://purl.uniprot.org/uniprot/C5CE41 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/521045:KOLE_RS08210 ^@ http://purl.uniprot.org/uniprot/B5M6L7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/521045:KOLE_RS04900 ^@ http://purl.uniprot.org/uniprot/C5CH14 ^@ Similarity ^@ Belongs to the fabD family. http://togogenome.org/gene/521045:KOLE_RS02250 ^@ http://purl.uniprot.org/uniprot/C5CE54 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS04565 ^@ http://purl.uniprot.org/uniprot/C5CGN1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrB/RnfD family.|||Cell inner membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/521045:KOLE_RS08675 ^@ http://purl.uniprot.org/uniprot/C5CFQ4 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/521045:KOLE_RS10580 ^@ http://purl.uniprot.org/uniprot/C5CI69 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/521045:KOLE_RS09900 ^@ http://purl.uniprot.org/uniprot/C5CH38 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS02350 ^@ http://purl.uniprot.org/uniprot/C5CE74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS00245 ^@ http://purl.uniprot.org/uniprot/C5CHD5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphopentomutase family.|||Binds 1 or 2 manganese ions.|||Cytoplasm|||Phosphotransfer between the C1 and C5 carbon atoms of pentose. http://togogenome.org/gene/521045:KOLE_RS10185 ^@ http://purl.uniprot.org/uniprot/C5CHL9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/521045:KOLE_RS10110 ^@ http://purl.uniprot.org/uniprot/C5CH78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS09775 ^@ http://purl.uniprot.org/uniprot/C5CGU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS04460 ^@ http://purl.uniprot.org/uniprot/C5CGL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CitM (TC 2.A.11) transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS05905 ^@ http://purl.uniprot.org/uniprot/C5CIL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS04575 ^@ http://purl.uniprot.org/uniprot/C5CGN3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell inner membrane|||Membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/521045:KOLE_RS04470 ^@ http://purl.uniprot.org/uniprot/C5CGL2 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/521045:KOLE_RS05395 ^@ http://purl.uniprot.org/uniprot/C5CHL7 ^@ Similarity ^@ Belongs to the glycosyltransferase 1 family. http://togogenome.org/gene/521045:KOLE_RS02975 ^@ http://purl.uniprot.org/uniprot/C5CEW8 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/521045:KOLE_RS08820 ^@ http://purl.uniprot.org/uniprot/C5CFT7 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/521045:KOLE_RS04275 ^@ http://purl.uniprot.org/uniprot/C5CGB6 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. http://togogenome.org/gene/521045:KOLE_RS09255 ^@ http://purl.uniprot.org/uniprot/C5CGD4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M32 family.|||Binds 1 zinc ion per subunit.|||Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. http://togogenome.org/gene/521045:KOLE_RS02825 ^@ http://purl.uniprot.org/uniprot/C5CEU0 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/521045:KOLE_RS07310 ^@ http://purl.uniprot.org/uniprot/C5CE43 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/521045:KOLE_RS00910 ^@ http://purl.uniprot.org/uniprot/C5CIG8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CoaE family.|||Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS08625 ^@ http://purl.uniprot.org/uniprot/C5CFP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS01855 ^@ http://purl.uniprot.org/uniprot/C5CDK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BioY family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS01675 ^@ http://purl.uniprot.org/uniprot/C5CDH1 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/521045:KOLE_RS04820 ^@ http://purl.uniprot.org/uniprot/C5CGZ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS03425 ^@ http://purl.uniprot.org/uniprot/C5CFB4 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/521045:KOLE_RS03395 ^@ http://purl.uniprot.org/uniprot/C5CFA8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/521045:KOLE_RS08740 ^@ http://purl.uniprot.org/uniprot/C5CFR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/521045:KOLE_RS09285 ^@ http://purl.uniprot.org/uniprot/C5CGE0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/521045:KOLE_RS10760 ^@ http://purl.uniprot.org/uniprot/C5CIA4 ^@ Similarity ^@ Belongs to the UPF0473 family. http://togogenome.org/gene/521045:KOLE_RS08055 ^@ http://purl.uniprot.org/uniprot/C5CF19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CitM (TC 2.A.11) transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS03905 ^@ http://purl.uniprot.org/uniprot/C5CG41 ^@ Similarity ^@ Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. http://togogenome.org/gene/521045:KOLE_RS08060 ^@ http://purl.uniprot.org/uniprot/C5CF24 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/521045:KOLE_RS02930 ^@ http://purl.uniprot.org/uniprot/C5CEV8 ^@ Cofactor|||Similarity ^@ Belongs to the PyrK family.|||Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/521045:KOLE_RS10390 ^@ http://purl.uniprot.org/uniprot/C5CHQ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS07345 ^@ http://purl.uniprot.org/uniprot/C5CEB2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/521045:KOLE_RS07745 ^@ http://purl.uniprot.org/uniprot/C5CEP7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/521045:KOLE_RS00485 ^@ http://purl.uniprot.org/uniprot/C5CHW7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS10950 ^@ http://purl.uniprot.org/uniprot/C5CIR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CitM (TC 2.A.11) transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS11115 ^@ http://purl.uniprot.org/uniprot/C5CGZ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS00100 ^@ http://purl.uniprot.org/uniprot/C5CHA9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase S24 family.|||Homodimer.|||Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. http://togogenome.org/gene/521045:KOLE_RS06190 ^@ http://purl.uniprot.org/uniprot/C5CJ08 ^@ Cofactor ^@ Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/521045:KOLE_RS02670 ^@ http://purl.uniprot.org/uniprot/C5CEK0 ^@ Similarity ^@ Belongs to the transposase IS21/IS408/IS1162 family. http://togogenome.org/gene/521045:KOLE_RS04450 ^@ http://purl.uniprot.org/uniprot/C5CGK9 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/521045:KOLE_RS04940 ^@ http://purl.uniprot.org/uniprot/C5CH22 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 130 family. http://togogenome.org/gene/521045:KOLE_RS00200 ^@ http://purl.uniprot.org/uniprot/C5CHC9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/521045:KOLE_RS09020 ^@ http://purl.uniprot.org/uniprot/C5CFX4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endoribonuclease YbeY family.|||Binds 1 zinc ion.|||Cytoplasm|||Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. http://togogenome.org/gene/521045:KOLE_RS03450 ^@ http://purl.uniprot.org/uniprot/C5CFH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS10200 ^@ http://purl.uniprot.org/uniprot/C5CHM2 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/521045:KOLE_RS01770 ^@ http://purl.uniprot.org/uniprot/C5CDI4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoD/SigA subfamily.|||Cytoplasm|||Interacts transiently with the RNA polymerase catalytic core.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. http://togogenome.org/gene/521045:KOLE_RS09515 ^@ http://purl.uniprot.org/uniprot/C5CGI3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/521045:KOLE_RS06515 ^@ http://purl.uniprot.org/uniprot/C5CDC4 ^@ Similarity ^@ Belongs to the transposase IS21/IS408/IS1162 family. http://togogenome.org/gene/521045:KOLE_RS08615 ^@ http://purl.uniprot.org/uniprot/C5CFP3 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/521045:KOLE_RS07230 ^@ http://purl.uniprot.org/uniprot/C5CE28 ^@ Similarity ^@ Belongs to the phosphate acetyltransferase and butyryltransferase family. http://togogenome.org/gene/521045:KOLE_RS07905 ^@ http://purl.uniprot.org/uniprot/C5CES8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.|||Binds 1 zinc ion per subunit.|||Cell inner membrane|||Homohexamer.|||In the C-terminal section; belongs to the peptidase M41 family.|||In the central section; belongs to the AAA ATPase family. http://togogenome.org/gene/521045:KOLE_RS06790 ^@ http://purl.uniprot.org/uniprot/C5CDN8 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/521045:KOLE_RS00630 ^@ http://purl.uniprot.org/uniprot/C5CIB3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS07865 ^@ http://purl.uniprot.org/uniprot/C5CES1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methylthiotransferase family. RimO subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS00975 ^@ http://purl.uniprot.org/uniprot/C5CIS4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/521045:KOLE_RS10260 ^@ http://purl.uniprot.org/uniprot/C5CHN4 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/521045:KOLE_RS00020 ^@ http://purl.uniprot.org/uniprot/C5CH93 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS00865 ^@ http://purl.uniprot.org/uniprot/C5CIF9 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/521045:KOLE_RS00800 ^@ http://purl.uniprot.org/uniprot/C5CIE7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS07355 ^@ http://purl.uniprot.org/uniprot/C5CEB4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.|||Belongs to the KhpA RNA-binding protein family.|||Cytoplasm|||Forms a complex with KhpB. http://togogenome.org/gene/521045:KOLE_RS00085 ^@ http://purl.uniprot.org/uniprot/C5CHA6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS09580 ^@ http://purl.uniprot.org/uniprot/C5CGQ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/521045:KOLE_RS06930 ^@ http://purl.uniprot.org/uniprot/C5CDR5 ^@ Function|||Similarity ^@ Belongs to the HrcA family.|||Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons. http://togogenome.org/gene/521045:KOLE_RS01475 ^@ http://purl.uniprot.org/uniprot/C5CD71 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/521045:KOLE_RS09985 ^@ http://purl.uniprot.org/uniprot/C5CH55 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/521045:KOLE_RS03870 ^@ http://purl.uniprot.org/uniprot/C5CG32 ^@ Similarity ^@ Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. http://togogenome.org/gene/521045:KOLE_RS06970 ^@ http://purl.uniprot.org/uniprot/C5CDY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS03605 ^@ http://purl.uniprot.org/uniprot/C5CFK9 ^@ Function|||Similarity ^@ Belongs to the PstS family.|||Involved in the system for phosphate transport across the cytoplasmic membrane. http://togogenome.org/gene/521045:KOLE_RS02600 ^@ http://purl.uniprot.org/uniprot/C5CEI7 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurE subfamily.|||Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.|||Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS09280 ^@ http://purl.uniprot.org/uniprot/C5CGD9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/521045:KOLE_RS07325 ^@ http://purl.uniprot.org/uniprot/C5CEA8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/521045:KOLE_RS11275 ^@ http://purl.uniprot.org/uniprot/C5CI91 ^@ Similarity ^@ Belongs to the asp23 family. http://togogenome.org/gene/521045:KOLE_RS09370 ^@ http://purl.uniprot.org/uniprot/C5CGF5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.|||Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.|||Homodimer. http://togogenome.org/gene/521045:KOLE_RS07395 ^@ http://purl.uniprot.org/uniprot/C5CEC1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the N7 position of a guanine in 16S rRNA. http://togogenome.org/gene/521045:KOLE_RS08810 ^@ http://purl.uniprot.org/uniprot/C5CFT5 ^@ Similarity ^@ Belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/521045:KOLE_RS00860 ^@ http://purl.uniprot.org/uniprot/C5CIF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS01535 ^@ http://purl.uniprot.org/uniprot/C5CD83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS03785 ^@ http://purl.uniprot.org/uniprot/C5CG18 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/521045:KOLE_RS08245 ^@ http://purl.uniprot.org/uniprot/B5M6M5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS07340 ^@ http://purl.uniprot.org/uniprot/C5CEB1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidine kinase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/521045:KOLE_RS07135 ^@ http://purl.uniprot.org/uniprot/C5CE12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS09275 ^@ http://purl.uniprot.org/uniprot/C5CGD8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/521045:KOLE_RS01010 ^@ http://purl.uniprot.org/uniprot/C5CIT4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS00660 ^@ http://purl.uniprot.org/uniprot/C5CIB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAL/histidase family.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS09265 ^@ http://purl.uniprot.org/uniprot/C5CGD6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS03550 ^@ http://purl.uniprot.org/uniprot/C5CFJ8 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein ModA family. http://togogenome.org/gene/521045:KOLE_RS03630 ^@ http://purl.uniprot.org/uniprot/C5CFL3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DtxR/MntR family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/521045:KOLE_RS00545 ^@ http://purl.uniprot.org/uniprot/C5CHX9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/521045:KOLE_RS05405 ^@ http://purl.uniprot.org/uniprot/C5CHZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS07880 ^@ http://purl.uniprot.org/uniprot/C5CES4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS08140 ^@ http://purl.uniprot.org/uniprot/C5CF39 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.|||In the C-terminal section; belongs to the NAD synthetase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS00255 ^@ http://purl.uniprot.org/uniprot/C5CHD6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. UvrA family.|||Cytoplasm|||Forms a heterotetramer with UvrB during the search for lesions.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. http://togogenome.org/gene/521045:KOLE_RS08100 ^@ http://purl.uniprot.org/uniprot/C5CF32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Membrane http://togogenome.org/gene/521045:KOLE_RS02605 ^@ http://purl.uniprot.org/uniprot/C5CEI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurF subfamily.|||Cytoplasm|||Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. http://togogenome.org/gene/521045:KOLE_RS10265 ^@ http://purl.uniprot.org/uniprot/C5CHN5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 3 Mg(2+) ions per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/521045:KOLE_RS02555 ^@ http://purl.uniprot.org/uniprot/C5CEH8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS07940 ^@ http://purl.uniprot.org/uniprot/C5CET5 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. http://togogenome.org/gene/521045:KOLE_RS02870 ^@ http://purl.uniprot.org/uniprot/C5CEU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS03545 ^@ http://purl.uniprot.org/uniprot/C5CFJ7 ^@ Function|||Similarity ^@ Belongs to the MoeA family.|||Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. http://togogenome.org/gene/521045:KOLE_RS03400 ^@ http://purl.uniprot.org/uniprot/C5CFA9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/521045:KOLE_RS03970 ^@ http://purl.uniprot.org/uniprot/C5CG57 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS06220 ^@ http://purl.uniprot.org/uniprot/C5CJ14 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the GTP cyclohydrolase II family.|||Binds 1 zinc ion per subunit.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.|||In the N-terminal section; belongs to the DHBP synthase family. http://togogenome.org/gene/521045:KOLE_RS04245 ^@ http://purl.uniprot.org/uniprot/C5CGB0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/521045:KOLE_RS06925 ^@ http://purl.uniprot.org/uniprot/C5CDR4 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurE subfamily.|||Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.|||Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS09545 ^@ http://purl.uniprot.org/uniprot/C5CGI9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/521045:KOLE_RS06435 ^@ http://purl.uniprot.org/uniprot/C5CDB1 ^@ Similarity ^@ Belongs to the IS21/IS1162 putative ATP-binding protein family. http://togogenome.org/gene/521045:KOLE_RS06065 ^@ http://purl.uniprot.org/uniprot/C5CIY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS09560 ^@ http://purl.uniprot.org/uniprot/C5CGQ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/521045:KOLE_RS02515 ^@ http://purl.uniprot.org/uniprot/C5CEH0 ^@ Similarity ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily. http://togogenome.org/gene/521045:KOLE_RS06975 ^@ http://purl.uniprot.org/uniprot/C5CDY4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.|||Cell membrane|||Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/521045:KOLE_RS04325 ^@ http://purl.uniprot.org/uniprot/C5CGC6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/521045:KOLE_RS02765 ^@ http://purl.uniprot.org/uniprot/C5CEL8 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/521045:KOLE_RS07760 ^@ http://purl.uniprot.org/uniprot/C5CEQ0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methylthiotransferase family. MiaB subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.|||Cytoplasm|||Monomer. http://togogenome.org/gene/521045:KOLE_RS08455 ^@ http://purl.uniprot.org/uniprot/C5CFF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS00950 ^@ http://purl.uniprot.org/uniprot/C5CIR9 ^@ Similarity ^@ Belongs to the complex I 51 kDa subunit family. http://togogenome.org/gene/521045:KOLE_RS02495 ^@ http://purl.uniprot.org/uniprot/C5CE93 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/521045:KOLE_RS02880 ^@ http://purl.uniprot.org/uniprot/C5CEV1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS03565 ^@ http://purl.uniprot.org/uniprot/C5CFK1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/521045:KOLE_RS07405 ^@ http://purl.uniprot.org/uniprot/C5CEC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS05870 ^@ http://purl.uniprot.org/uniprot/C5CIK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS01750 ^@ http://purl.uniprot.org/uniprot/C5CDI0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/521045:KOLE_RS00695 ^@ http://purl.uniprot.org/uniprot/C5CIC5 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/521045:KOLE_RS02120 ^@ http://purl.uniprot.org/uniprot/C5CDX0 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/521045:KOLE_RS09635 ^@ http://purl.uniprot.org/uniprot/C5CGR9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/521045:KOLE_RS02045 ^@ http://purl.uniprot.org/uniprot/C5CDV5 ^@ Caution|||Function|||Similarity ^@ Belongs to the methylglyoxal synthase family.|||Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS08360 ^@ http://purl.uniprot.org/uniprot/C5CFD3 ^@ Similarity ^@ Belongs to the DprA/Smf family. http://togogenome.org/gene/521045:KOLE_RS08665 ^@ http://purl.uniprot.org/uniprot/C5CFQ2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/521045:KOLE_RS00600 ^@ http://purl.uniprot.org/uniprot/C5CHY7 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/521045:KOLE_RS10350 ^@ http://purl.uniprot.org/uniprot/C5CHQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS01120 ^@ http://purl.uniprot.org/uniprot/C5CIV6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/521045:KOLE_RS01115 ^@ http://purl.uniprot.org/uniprot/C5CIV5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase gamma chain family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. http://togogenome.org/gene/521045:KOLE_RS09700 ^@ http://purl.uniprot.org/uniprot/C5CGT2 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/521045:KOLE_RS09765 ^@ http://purl.uniprot.org/uniprot/C5CGU5 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/521045:KOLE_RS04500 ^@ http://purl.uniprot.org/uniprot/C5CGL8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvC family.|||Binds 2 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA. http://togogenome.org/gene/521045:KOLE_RS08110 ^@ http://purl.uniprot.org/uniprot/C5CF34 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/521045:KOLE_RS04045 ^@ http://purl.uniprot.org/uniprot/C5CG70 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS09705 ^@ http://purl.uniprot.org/uniprot/C5CGT3 ^@ Caution|||Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS00075 ^@ http://purl.uniprot.org/uniprot/C5CHA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the etk/wzc family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS00925 ^@ http://purl.uniprot.org/uniprot/C5CIH1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/521045:KOLE_RS06465 ^@ http://purl.uniprot.org/uniprot/C5CDB5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS00560 ^@ http://purl.uniprot.org/uniprot/C5CHY2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/521045:KOLE_RS05410 ^@ http://purl.uniprot.org/uniprot/C5CHZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS09525 ^@ http://purl.uniprot.org/uniprot/C5CGI5 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/521045:KOLE_RS10735 ^@ http://purl.uniprot.org/uniprot/C5CI99 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/521045:KOLE_RS10345 ^@ http://purl.uniprot.org/uniprot/C5CHP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS01935 ^@ http://purl.uniprot.org/uniprot/C5CDT4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 57 family. http://togogenome.org/gene/521045:KOLE_RS05380 ^@ http://purl.uniprot.org/uniprot/C5CHL4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/521045:KOLE_RS07050 ^@ http://purl.uniprot.org/uniprot/C5CDZ7 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/521045:KOLE_RS08170 ^@ http://purl.uniprot.org/uniprot/C5CF44 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. C-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/521045:KOLE_RS07770 ^@ http://purl.uniprot.org/uniprot/C5CEQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XseA family.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS08105 ^@ http://purl.uniprot.org/uniprot/C5CF33 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer. http://togogenome.org/gene/521045:KOLE_RS02390 ^@ http://purl.uniprot.org/uniprot/C5CE82 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS07450 ^@ http://purl.uniprot.org/uniprot/C5CED2 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/521045:KOLE_RS10960 ^@ http://purl.uniprot.org/uniprot/C5CIR3 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/521045:KOLE_RS05085 ^@ http://purl.uniprot.org/uniprot/C5CHF9 ^@ Similarity ^@ Belongs to the peptidase C69 family. http://togogenome.org/gene/521045:KOLE_RS08475 ^@ http://purl.uniprot.org/uniprot/C5CFF7 ^@ Similarity ^@ Belongs to the shaker potassium channel beta subunit family. http://togogenome.org/gene/521045:KOLE_RS02885 ^@ http://purl.uniprot.org/uniprot/C5CEV2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS10935 ^@ http://purl.uniprot.org/uniprot/C5CIQ8 ^@ Similarity ^@ Belongs to the phosphate acetyltransferase and butyryltransferase family. http://togogenome.org/gene/521045:KOLE_RS00195 ^@ http://purl.uniprot.org/uniprot/C5CHC8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/521045:KOLE_RS08495 ^@ http://purl.uniprot.org/uniprot/C5CFG1 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.|||Cell inner membrane|||Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Membrane|||Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function. http://togogenome.org/gene/521045:KOLE_RS04540 ^@ http://purl.uniprot.org/uniprot/C5CGM6 ^@ Similarity ^@ Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. http://togogenome.org/gene/521045:KOLE_RS09290 ^@ http://purl.uniprot.org/uniprot/C5CGE1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/521045:KOLE_RS05460 ^@ http://purl.uniprot.org/uniprot/C5CI06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS08395 ^@ http://purl.uniprot.org/uniprot/C5CFE0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/521045:KOLE_RS07205 ^@ http://purl.uniprot.org/uniprot/C5CE23 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS01060 ^@ http://purl.uniprot.org/uniprot/C5CIU4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvB family.|||Cytoplasm|||Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.|||Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA. http://togogenome.org/gene/521045:KOLE_RS07780 ^@ http://purl.uniprot.org/uniprot/C5CEQ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TmcAL family.|||Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS09490 ^@ http://purl.uniprot.org/uniprot/C5CGH8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/521045:KOLE_RS01130 ^@ http://purl.uniprot.org/uniprot/C5CIV8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase B chain family.|||Cell inner membrane|||Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Membrane http://togogenome.org/gene/521045:KOLE_RS08590 ^@ http://purl.uniprot.org/uniprot/C5CFN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A24 family.|||Membrane http://togogenome.org/gene/521045:KOLE_RS07890 ^@ http://purl.uniprot.org/uniprot/C5CES6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase Y family.|||Cell membrane|||Endoribonuclease that initiates mRNA decay. http://togogenome.org/gene/521045:KOLE_RS07390 ^@ http://purl.uniprot.org/uniprot/C5CEC0 ^@ Function|||Similarity ^@ Belongs to the GTP cyclohydrolase IV family.|||Converts GTP to 7,8-dihydroneopterin triphosphate. http://togogenome.org/gene/521045:KOLE_RS06940 ^@ http://purl.uniprot.org/uniprot/C5CDR7 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/521045:KOLE_RS01135 ^@ http://purl.uniprot.org/uniprot/C5CIV9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase C chain family.|||Cell inner membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.|||Membrane http://togogenome.org/gene/521045:KOLE_RS10640 ^@ http://purl.uniprot.org/uniprot/C5CI80 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS02910 ^@ http://purl.uniprot.org/uniprot/C5CEV4 ^@ Function|||Similarity ^@ Belongs to the complex I 30 kDa subunit family.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. http://togogenome.org/gene/521045:KOLE_RS10805 ^@ http://purl.uniprot.org/uniprot/C5CIN2 ^@ Cofactor|||Similarity ^@ Belongs to the rubredoxin family.|||Binds 1 Fe(3+) ion per subunit. http://togogenome.org/gene/521045:KOLE_RS02285 ^@ http://purl.uniprot.org/uniprot/C5CE61 ^@ Similarity ^@ Belongs to the Cob(I)alamin adenosyltransferase family. http://togogenome.org/gene/521045:KOLE_RS10670 ^@ http://purl.uniprot.org/uniprot/C5CI86 ^@ Similarity ^@ Belongs to the asp23 family. http://togogenome.org/gene/521045:KOLE_RS01065 ^@ http://purl.uniprot.org/uniprot/C5CIU5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/521045:KOLE_RS01595 ^@ http://purl.uniprot.org/uniprot/C5CD95 ^@ Caution|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS00080 ^@ http://purl.uniprot.org/uniprot/C5CHA5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS04595 ^@ http://purl.uniprot.org/uniprot/C5CGP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Membrane http://togogenome.org/gene/521045:KOLE_RS06310 ^@ http://purl.uniprot.org/uniprot/C5CJ33 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS08815 ^@ http://purl.uniprot.org/uniprot/C5CFT6 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/521045:KOLE_RS00700 ^@ http://purl.uniprot.org/uniprot/C5CIC6 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.|||Cell inner membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Requires K(+) for maximal activity.|||Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane. http://togogenome.org/gene/521045:KOLE_RS07800 ^@ http://purl.uniprot.org/uniprot/C5CEQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS06115 ^@ http://purl.uniprot.org/uniprot/C5CIZ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS01985 ^@ http://purl.uniprot.org/uniprot/C5CDU3 ^@ Similarity ^@ Belongs to the peptidase S41A family. http://togogenome.org/gene/521045:KOLE_RS05020 ^@ http://purl.uniprot.org/uniprot/C5CHE8 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/521045:KOLE_RS07020 ^@ http://purl.uniprot.org/uniprot/C5CDZ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS01880 ^@ http://purl.uniprot.org/uniprot/C5CDS3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS07400 ^@ http://purl.uniprot.org/uniprot/C5CEC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmI family.|||Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS00920 ^@ http://purl.uniprot.org/uniprot/C5CIH0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI family.|||Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS01340 ^@ http://purl.uniprot.org/uniprot/C5CD44 ^@ Function|||Similarity ^@ Belongs to the band 7/mec-2 family. HflC subfamily.|||HflC and HflK could regulate a protease. http://togogenome.org/gene/521045:KOLE_RS04480 ^@ http://purl.uniprot.org/uniprot/C5CGL4 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/521045:KOLE_RS06725 ^@ http://purl.uniprot.org/uniprot/C5CDM5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS07605 ^@ http://purl.uniprot.org/uniprot/C5CEF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS09770 ^@ http://purl.uniprot.org/uniprot/C5CGU6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A8 family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This protein specifically catalyzes the removal of signal peptides from prolipoproteins. http://togogenome.org/gene/521045:KOLE_RS02320 ^@ http://purl.uniprot.org/uniprot/C5CE68 ^@ Function|||Similarity ^@ Belongs to the CobT family.|||Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). http://togogenome.org/gene/521045:KOLE_RS01600 ^@ http://purl.uniprot.org/uniprot/C5CD96 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with bS18 to 16S ribosomal RNA. http://togogenome.org/gene/521045:KOLE_RS00495 ^@ http://purl.uniprot.org/uniprot/C5CHW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. ArgB subfamily.|||Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS09675 ^@ http://purl.uniprot.org/uniprot/C5CGS7 ^@ Similarity ^@ Belongs to the TlyA family. http://togogenome.org/gene/521045:KOLE_RS03175 ^@ http://purl.uniprot.org/uniprot/C5CF65 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/521045:KOLE_RS04475 ^@ http://purl.uniprot.org/uniprot/C5CGL3 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/521045:KOLE_RS08390 ^@ http://purl.uniprot.org/uniprot/C5CFD9 ^@ Function|||Similarity ^@ Belongs to the alanine racemase family.|||Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. http://togogenome.org/gene/521045:KOLE_RS00540 ^@ http://purl.uniprot.org/uniprot/C5CHX8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapB family.|||Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. http://togogenome.org/gene/521045:KOLE_RS07930 ^@ http://purl.uniprot.org/uniprot/C5CET3 ^@ Similarity|||Subunit ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.|||Homodimer. http://togogenome.org/gene/521045:KOLE_RS10250 ^@ http://purl.uniprot.org/uniprot/C5CHN2 ^@ Function|||Similarity ^@ Belongs to the WhiA family.|||Involved in cell division and chromosome segregation. http://togogenome.org/gene/521045:KOLE_RS02225 ^@ http://purl.uniprot.org/uniprot/C5CE49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/521045:KOLE_RS00530 ^@ http://purl.uniprot.org/uniprot/C5CHX6 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/521045:KOLE_RS09465 ^@ http://purl.uniprot.org/uniprot/C5CGH3 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/521045:KOLE_RS01140 ^@ http://purl.uniprot.org/uniprot/C5CIW0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase A chain family.|||Cell inner membrane|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.|||Membrane http://togogenome.org/gene/521045:KOLE_RS01640 ^@ http://purl.uniprot.org/uniprot/C5CDG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||Cytoplasm|||Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/521045:KOLE_RS03525 ^@ http://purl.uniprot.org/uniprot/C5CFJ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/521045:KOLE_RS08375 ^@ http://purl.uniprot.org/uniprot/C5CFD6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the D-alanine--D-alanine ligase family.|||Binds 2 magnesium or manganese ions per subunit.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/521045:KOLE_RS00930 ^@ http://purl.uniprot.org/uniprot/C5CIR5 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/521045:KOLE_RS08080 ^@ http://purl.uniprot.org/uniprot/C5CF28 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/521045:KOLE_RS03780 ^@ http://purl.uniprot.org/uniprot/C5CG17 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/521045:KOLE_RS08915 ^@ http://purl.uniprot.org/uniprot/C5CFV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/521045:KOLE_RS05640 ^@ http://purl.uniprot.org/uniprot/C5CI42 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS09445 ^@ http://purl.uniprot.org/uniprot/C5CGG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endonuclease V family.|||Cytoplasm|||DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. http://togogenome.org/gene/521045:KOLE_RS06060 ^@ http://purl.uniprot.org/uniprot/C5CIY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS10425 ^@ http://purl.uniprot.org/uniprot/C5CHR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.|||Cell membrane|||Membrane http://togogenome.org/gene/521045:KOLE_RS07775 ^@ http://purl.uniprot.org/uniprot/C5CEQ3 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanD family.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.|||Cytoplasm|||Heterooctamer of four alpha and four beta subunits.|||Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus. http://togogenome.org/gene/521045:KOLE_RS01105 ^@ http://purl.uniprot.org/uniprot/C5CIV3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/521045:KOLE_RS09590 ^@ http://purl.uniprot.org/uniprot/C5CGR0 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/521045:KOLE_RS04410 ^@ http://purl.uniprot.org/uniprot/C5CGK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS08620 ^@ http://purl.uniprot.org/uniprot/C5CFP4 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/521045:KOLE_RS08745 ^@ http://purl.uniprot.org/uniprot/C5CFR8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/521045:KOLE_RS10255 ^@ http://purl.uniprot.org/uniprot/C5CHN3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NrdR family.|||Binds 1 zinc ion.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/521045:KOLE_RS10730 ^@ http://purl.uniprot.org/uniprot/C5CI98 ^@ Function|||Similarity ^@ Belongs to the NadD family.|||Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). http://togogenome.org/gene/521045:KOLE_RS09630 ^@ http://purl.uniprot.org/uniprot/C5CGR8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/521045:KOLE_RS06745 ^@ http://purl.uniprot.org/uniprot/C5CDM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/521045:KOLE_RS07665 ^@ http://purl.uniprot.org/uniprot/C5CEN1 ^@ Function|||Similarity ^@ Belongs to the MinE family.|||Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. http://togogenome.org/gene/521045:KOLE_RS02370 ^@ http://purl.uniprot.org/uniprot/C5CE78 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/521045:KOLE_RS07580 ^@ http://purl.uniprot.org/uniprot/C5CEF5 ^@ Similarity ^@ Belongs to the transposase IS21/IS408/IS1162 family. http://togogenome.org/gene/521045:KOLE_RS01825 ^@ http://purl.uniprot.org/uniprot/C5CDJ6 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/521045:KOLE_RS04070 ^@ http://purl.uniprot.org/uniprot/C5CG74 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/521045:KOLE_RS06500 ^@ http://purl.uniprot.org/uniprot/C5CDC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial sugar transferase family.|||Membrane http://togogenome.org/gene/521045:KOLE_RS10245 ^@ http://purl.uniprot.org/uniprot/C5CHN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gluconeogenesis factor family.|||Cytoplasm|||Required for morphogenesis under gluconeogenic growth conditions. http://togogenome.org/gene/521045:KOLE_RS04465 ^@ http://purl.uniprot.org/uniprot/C5CGL1 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/521045:KOLE_RS00210 ^@ http://purl.uniprot.org/uniprot/C5CHD1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MinC family.|||Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.|||Interacts with MinD and FtsZ. http://togogenome.org/gene/521045:KOLE_RS03510 ^@ http://purl.uniprot.org/uniprot/C5CFJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/521045:KOLE_RS03600 ^@ http://purl.uniprot.org/uniprot/C5CFK8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/521045:KOLE_RS09350 ^@ http://purl.uniprot.org/uniprot/C5CGF1 ^@ Similarity ^@ Belongs to the YicC/YloC family. http://togogenome.org/gene/521045:KOLE_RS10700 ^@ http://purl.uniprot.org/uniprot/C5CI92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/521045:KOLE_RS09530 ^@ http://purl.uniprot.org/uniprot/C5CGI6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/521045:KOLE_RS00270 ^@ http://purl.uniprot.org/uniprot/C5CHD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/521045:KOLE_RS05485 ^@ http://purl.uniprot.org/uniprot/C5CI11 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/521045:KOLE_RS01585 ^@ http://purl.uniprot.org/uniprot/C5CD93 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/521045:KOLE_RS04770 ^@ http://purl.uniprot.org/uniprot/C5CGY9 ^@ Similarity ^@ Belongs to the FldB/FldC dehydratase alpha/beta subunit family. http://togogenome.org/gene/521045:KOLE_RS03790 ^@ http://purl.uniprot.org/uniprot/C5CG19 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/521045:KOLE_RS09965 ^@ http://purl.uniprot.org/uniprot/C5CH51 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/521045:KOLE_RS10315 ^@ http://purl.uniprot.org/uniprot/C5CHP4 ^@ Domain|||Function|||Similarity ^@ Belongs to the RecA family. RadA subfamily.|||DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.|||Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.|||The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. http://togogenome.org/gene/521045:KOLE_RS01370 ^@ http://purl.uniprot.org/uniprot/C5CD50 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers. http://togogenome.org/gene/521045:KOLE_RS01230 ^@ http://purl.uniprot.org/uniprot/C5CIX8 ^@ Similarity ^@ Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/521045:KOLE_RS05075 ^@ http://purl.uniprot.org/uniprot/C5CHF7 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/521045:KOLE_RS05285 ^@ http://purl.uniprot.org/uniprot/C5CHJ6 ^@ Cofactor|||Similarity ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.