http://togogenome.org/gene/523841:E6P09_RS00455 ^@ http://purl.uniprot.org/uniprot/I3R6S5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PurS family.|||Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/523841:E6P09_RS01070 ^@ http://purl.uniprot.org/uniprot/M0IUN7 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/523841:E6P09_RS11225 ^@ http://purl.uniprot.org/uniprot/I3R533 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/523841:E6P09_RS05110 ^@ http://purl.uniprot.org/uniprot/M0J2P0 ^@ Similarity ^@ Belongs to the UPF0215 family. http://togogenome.org/gene/523841:E6P09_RS02940 ^@ http://purl.uniprot.org/uniprot/I3R8V5 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily. http://togogenome.org/gene/523841:E6P09_RS15530 ^@ http://purl.uniprot.org/uniprot/I3RA69 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/523841:E6P09_RS14600 ^@ http://purl.uniprot.org/uniprot/I3R7B4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS14180 ^@ http://purl.uniprot.org/uniprot/I3R7I7 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/523841:E6P09_RS00845 ^@ http://purl.uniprot.org/uniprot/I3R6J7 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/523841:E6P09_RS04770 ^@ http://purl.uniprot.org/uniprot/I3R1G3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.|||Part of the RNA polymerase complex. http://togogenome.org/gene/523841:E6P09_RS06500 ^@ http://purl.uniprot.org/uniprot/I3R2F4 ^@ Caution|||Function|||Similarity ^@ Belongs to the TFIIB family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/523841:E6P09_RS13880 ^@ http://purl.uniprot.org/uniprot/I3R7Q1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/523841:E6P09_RS13920 ^@ http://purl.uniprot.org/uniprot/I3R7P3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/523841:E6P09_RS07910 ^@ http://purl.uniprot.org/uniprot/M0J520 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS02405 ^@ http://purl.uniprot.org/uniprot/I3R5P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS03140 ^@ http://purl.uniprot.org/uniprot/I3R0J4 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/523841:E6P09_RS05930 ^@ http://purl.uniprot.org/uniprot/I3R242 ^@ Similarity ^@ Belongs to the UPF0284 family. http://togogenome.org/gene/523841:E6P09_RS00775 ^@ http://purl.uniprot.org/uniprot/I3R6L2 ^@ Subunit ^@ Homotrimer. http://togogenome.org/gene/523841:E6P09_RS03435 ^@ http://purl.uniprot.org/uniprot/I3R0Q1 ^@ Function ^@ Part of a potassium transport system. http://togogenome.org/gene/523841:E6P09_RS03340 ^@ http://purl.uniprot.org/uniprot/I3R0N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS09115 ^@ http://purl.uniprot.org/uniprot/I3R3X3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Archaeal flagellum|||Belongs to the archaeal flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella. http://togogenome.org/gene/523841:E6P09_RS10700 ^@ http://purl.uniprot.org/uniprot/I3R4S9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the TPP enzyme family. MenD subfamily.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS08355 ^@ http://purl.uniprot.org/uniprot/I3R3H1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS13675 ^@ http://purl.uniprot.org/uniprot/I3R7T8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS04885 ^@ http://purl.uniprot.org/uniprot/I3R1I8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS19320 ^@ http://purl.uniprot.org/uniprot/I3R975 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS02740 ^@ http://purl.uniprot.org/uniprot/I3R8R5 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/523841:E6P09_RS08540 ^@ http://purl.uniprot.org/uniprot/I3R3K9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||S-layer http://togogenome.org/gene/523841:E6P09_RS06365 ^@ http://purl.uniprot.org/uniprot/I3R2C8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS01380 ^@ http://purl.uniprot.org/uniprot/I3R696 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/523841:E6P09_RS05080 ^@ http://purl.uniprot.org/uniprot/I3R1M8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC61-beta family.|||Cell membrane|||Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.|||Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.|||Membrane http://togogenome.org/gene/523841:E6P09_RS10985 ^@ http://purl.uniprot.org/uniprot/I3R4Y7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS15290 ^@ http://purl.uniprot.org/uniprot/I3RAB8 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/523841:E6P09_RS05880 ^@ http://purl.uniprot.org/uniprot/I3R230 ^@ Similarity ^@ Belongs to the ComB family. http://togogenome.org/gene/523841:E6P09_RS03030 ^@ http://purl.uniprot.org/uniprot/I3R8X3 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD-dependent DNA ligase family. LigA subfamily.|||DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS12495 ^@ http://purl.uniprot.org/uniprot/I3R8G7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS06760 ^@ http://purl.uniprot.org/uniprot/I3R2K9 ^@ Similarity ^@ Belongs to the TrpC family. http://togogenome.org/gene/523841:E6P09_RS04595 ^@ http://purl.uniprot.org/uniprot/I3R1D0 ^@ Function|||Similarity ^@ Belongs to the V-ATPase F subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/523841:E6P09_RS18345 ^@ http://purl.uniprot.org/uniprot/I3RA68 ^@ Caution|||Function|||Similarity ^@ Belongs to the TBP family.|||General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS13875 ^@ http://purl.uniprot.org/uniprot/I3R7Q2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/523841:E6P09_RS05215 ^@ http://purl.uniprot.org/uniprot/I3R1Q4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS12975 ^@ http://purl.uniprot.org/uniprot/I3R877 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/523841:E6P09_RS13910 ^@ http://purl.uniprot.org/uniprot/I3R7P5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/523841:E6P09_RS11910 ^@ http://purl.uniprot.org/uniprot/I3R5H0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS18420 ^@ http://purl.uniprot.org/uniprot/I3R9E2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS11680 ^@ http://purl.uniprot.org/uniprot/I3R5C7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS08095 ^@ http://purl.uniprot.org/uniprot/I3R3B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS04215 ^@ http://purl.uniprot.org/uniprot/I3R152 ^@ Function ^@ Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/523841:E6P09_RS13795 ^@ http://purl.uniprot.org/uniprot/I3R7R5 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/523841:E6P09_RS17380 ^@ http://purl.uniprot.org/uniprot/I3R9L6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NosZ family.|||Homodimer.|||In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.|||Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide.|||Periplasm http://togogenome.org/gene/523841:E6P09_RS12810 ^@ http://purl.uniprot.org/uniprot/I3R8A8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/523841:E6P09_RS13860 ^@ http://purl.uniprot.org/uniprot/I3R7Q5 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/523841:E6P09_RS11840 ^@ http://purl.uniprot.org/uniprot/I3R5F7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyltransferase superfamily. Fibrillarin family.|||Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.|||Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. http://togogenome.org/gene/523841:E6P09_RS06875 ^@ http://purl.uniprot.org/uniprot/I3R2N2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS00740 ^@ http://purl.uniprot.org/uniprot/I3R6L9 ^@ Cofactor ^@ Binds 1 copper ion per subunit. http://togogenome.org/gene/523841:E6P09_RS08340 ^@ http://purl.uniprot.org/uniprot/I3R3G7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/523841:E6P09_RS09795 ^@ http://purl.uniprot.org/uniprot/I3R4A5 ^@ Similarity ^@ Belongs to the UPF0173 family. http://togogenome.org/gene/523841:E6P09_RS11805 ^@ http://purl.uniprot.org/uniprot/I3R5F1 ^@ Similarity ^@ Belongs to the truncated hemoglobin family. Group I subfamily. http://togogenome.org/gene/523841:E6P09_RS14710 ^@ http://purl.uniprot.org/uniprot/I3R792 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/523841:E6P09_RS14595 ^@ http://purl.uniprot.org/uniprot/I3R7B5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS06305 ^@ http://purl.uniprot.org/uniprot/I3R2B5 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.|||Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Homohexamer. Dimer of a homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Purine nucleoside phosphorylase involved in purine salvage. http://togogenome.org/gene/523841:E6P09_RS04775 ^@ http://purl.uniprot.org/uniprot/I3R1G5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NusA family.|||Cytoplasm|||Participates in transcription termination. http://togogenome.org/gene/523841:E6P09_RS18500 ^@ http://purl.uniprot.org/uniprot/I3R9G2 ^@ Caution|||Function|||Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.|||Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS03285 ^@ http://purl.uniprot.org/uniprot/I3R0M2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS03420 ^@ http://purl.uniprot.org/uniprot/I3R0P9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal DNA polymerase II family.|||Heterodimer of a large subunit and a small subunit.|||Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. http://togogenome.org/gene/523841:E6P09_RS07820 ^@ http://purl.uniprot.org/uniprot/I3R363 ^@ Similarity ^@ Belongs to the peptidase S9C family. http://togogenome.org/gene/523841:E6P09_RS07925 ^@ http://purl.uniprot.org/uniprot/I3R384 ^@ Similarity ^@ Belongs to the complex I subunit 3 family. http://togogenome.org/gene/523841:E6P09_RS06830 ^@ http://purl.uniprot.org/uniprot/I3R2M3 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily. http://togogenome.org/gene/523841:E6P09_RS12860 ^@ http://purl.uniprot.org/uniprot/I3R899 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/523841:E6P09_RS17885 ^@ http://purl.uniprot.org/uniprot/I3R9X1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS05720 ^@ http://purl.uniprot.org/uniprot/I3R200 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/523841:E6P09_RS18585 ^@ http://purl.uniprot.org/uniprot/I3R9H8 ^@ Domain|||Function|||Miscellaneous|||Similarity ^@ Belongs to the CobB/CbiA family.|||Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.|||Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.|||The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate. http://togogenome.org/gene/523841:E6P09_RS10625 ^@ http://purl.uniprot.org/uniprot/I3R4R5 ^@ Similarity|||Subunit ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Homohexamer. http://togogenome.org/gene/523841:E6P09_RS13235 ^@ http://purl.uniprot.org/uniprot/I3R828 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase small subunit family.|||Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/523841:E6P09_RS03240 ^@ http://purl.uniprot.org/uniprot/I3R0L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS07035 ^@ http://purl.uniprot.org/uniprot/I3R2R3 ^@ Similarity ^@ Belongs to the methylamine corrinoid protein family. http://togogenome.org/gene/523841:E6P09_RS01625 ^@ http://purl.uniprot.org/uniprot/I3R646 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/523841:E6P09_RS17720 ^@ http://purl.uniprot.org/uniprot/I3R9U1 ^@ Similarity ^@ Belongs to the phosphosulfolactate synthase family. http://togogenome.org/gene/523841:E6P09_RS01955 ^@ http://purl.uniprot.org/uniprot/I3R5Y4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS10640 ^@ http://purl.uniprot.org/uniprot/I3R4R8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS13850 ^@ http://purl.uniprot.org/uniprot/I3R7Q7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29. http://togogenome.org/gene/523841:E6P09_RS13755 ^@ http://purl.uniprot.org/uniprot/I3R7S3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NadC/ModD family.|||Hexamer formed by 3 homodimers.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/523841:E6P09_RS08655 ^@ http://purl.uniprot.org/uniprot/I3R3N3 ^@ Cofactor ^@ The crystal structure with reduced Cu(1+) has also been determined. http://togogenome.org/gene/523841:E6P09_RS12075 ^@ http://purl.uniprot.org/uniprot/I3R5K4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS14375 ^@ http://purl.uniprot.org/uniprot/I3R7F4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/523841:E6P09_RS13865 ^@ http://purl.uniprot.org/uniprot/I3R7Q4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/523841:E6P09_RS08410 ^@ http://purl.uniprot.org/uniprot/I3R3I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS03670 ^@ http://purl.uniprot.org/uniprot/I3R0U9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/523841:E6P09_RS04815 ^@ http://purl.uniprot.org/uniprot/I3R1H4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/523841:E6P09_RS06060 ^@ http://purl.uniprot.org/uniprot/A0A059TRL8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS04765 ^@ http://purl.uniprot.org/uniprot/M0J0K1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds at least 2 Zn(2+) per subunit.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/523841:E6P09_RS13935 ^@ http://purl.uniprot.org/uniprot/M0IQX1|||http://purl.uniprot.org/uniprot/P50561 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/523841:E6P09_RS08480 ^@ http://purl.uniprot.org/uniprot/M0J6I5|||http://purl.uniprot.org/uniprot/Q977U7 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Induction|||Miscellaneous|||Similarity|||Subunit ^@ Activated by molar concentrations of KCl or NaCl. Inhibited by EDTA in vitro.|||Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.|||Binds 2 Zn(2+) ions per subunit. One of the zinc atoms is essential for catalytic activity while the other has a structural function, according to Ref.4. However, the crystal structures show a single zinc ion, the catalytic one.|||Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway.|||Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate. Displays broad substrate specificity since it is able to catalyze the oxidation of a number of alternative aldose sugars, such as D-xylose, D-galactose, and D-fucose, to the corresponding glyconate. Can utilize both NAD(+) and NADP(+) as electron acceptor, with a preference for NADP(+). Physiologically, seems to be involved in the degradation of glucose through a modified Entner-Doudoroff pathway.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The reaction follows an ordered Bi-Bi kinetic mechanism, involving an ordered binding of NADP(+) and D-glucose, followed by an ordered released of gluconolactone and NADPH.|||Up-regulated by glucose. http://togogenome.org/gene/523841:E6P09_RS14855 ^@ http://purl.uniprot.org/uniprot/I3R763 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/523841:E6P09_RS07875 ^@ http://purl.uniprot.org/uniprot/I3R374 ^@ Similarity ^@ In the C-terminal section; belongs to the complex I 49 kDa subunit family. http://togogenome.org/gene/523841:E6P09_RS08345 ^@ http://purl.uniprot.org/uniprot/I3R3G8 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS05445 ^@ http://purl.uniprot.org/uniprot/M0J090 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/523841:E6P09_RS08380 ^@ http://purl.uniprot.org/uniprot/I3R3H6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS00460 ^@ http://purl.uniprot.org/uniprot/I3R6S4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/523841:E6P09_RS07965 ^@ http://purl.uniprot.org/uniprot/I3R392 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS18195 ^@ http://purl.uniprot.org/uniprot/I3RA39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS18675 ^@ http://purl.uniprot.org/uniprot/I3R9J6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS17205 ^@ http://purl.uniprot.org/uniprot/I3RAJ2 ^@ Similarity ^@ In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/523841:E6P09_RS14160 ^@ http://purl.uniprot.org/uniprot/I3R7J1 ^@ Similarity ^@ Belongs to the IPP isomerase type 1 family. http://togogenome.org/gene/523841:E6P09_RS18450 ^@ http://purl.uniprot.org/uniprot/I3R9F2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS12385 ^@ http://purl.uniprot.org/uniprot/I3R8J0 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/523841:E6P09_RS17565 ^@ http://purl.uniprot.org/uniprot/I3R9Q7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS08185 ^@ http://purl.uniprot.org/uniprot/I3R3D5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/523841:E6P09_RS06555 ^@ http://purl.uniprot.org/uniprot/I3R2G6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CetZ family.|||Cytoplasm|||Involved in cell shape control. http://togogenome.org/gene/523841:E6P09_RS12980 ^@ http://purl.uniprot.org/uniprot/I3R876 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.|||Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure. http://togogenome.org/gene/523841:E6P09_RS03005 ^@ http://purl.uniprot.org/uniprot/I3R8W7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. MetX family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. http://togogenome.org/gene/523841:E6P09_RS17715 ^@ http://purl.uniprot.org/uniprot/I3R9U0 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS04325 ^@ http://purl.uniprot.org/uniprot/I3R176 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ 12-fold increase in the presence of 2-oxoglutarate. Up to 18-fold increase in the presence of 2-oxoglutarate and GlnK1 or GlnK2. Inhibited by AMP and glutamine.|||Belongs to the glutamine synthetase family.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homododecamer (PubMed:23069245). Interacts with the nitrogen regulatory proteins GlnK1 and GlnK2 in the presence of 2-oxoglutarate (PubMed:23069245).|||Probably involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. http://togogenome.org/gene/523841:E6P09_RS09270 ^@ http://purl.uniprot.org/uniprot/I3R405 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/523841:E6P09_RS00375 ^@ http://purl.uniprot.org/uniprot/I3R6U2 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/523841:E6P09_RS18665 ^@ http://purl.uniprot.org/uniprot/I3R9J4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CbiM family.|||Cell membrane|||Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.|||Membrane|||Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. http://togogenome.org/gene/523841:E6P09_RS16095 ^@ http://purl.uniprot.org/uniprot/I3RB81 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS18280 ^@ http://purl.uniprot.org/uniprot/I3RA55 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/523841:E6P09_RS07345 ^@ http://purl.uniprot.org/uniprot/I3R2X5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS15395 ^@ http://purl.uniprot.org/uniprot/I3RA99 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/523841:E6P09_RS15975 ^@ http://purl.uniprot.org/uniprot/I3RBA5 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/523841:E6P09_RS08090 ^@ http://purl.uniprot.org/uniprot/I3R3B8 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.|||Cell membrane|||Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.|||In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/523841:E6P09_RS09085 ^@ http://purl.uniprot.org/uniprot/I3R3W7 ^@ Function|||Similarity ^@ Belongs to the CheD family.|||Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis. http://togogenome.org/gene/523841:E6P09_RS12770 ^@ http://purl.uniprot.org/uniprot/I3R8B5 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS10875 ^@ http://purl.uniprot.org/uniprot/M0J6F9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/523841:E6P09_RS03300 ^@ http://purl.uniprot.org/uniprot/I3R0M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS07170 ^@ http://purl.uniprot.org/uniprot/I3R2U0 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/523841:E6P09_RS02630 ^@ http://purl.uniprot.org/uniprot/I3R8P4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/523841:E6P09_RS14860 ^@ http://purl.uniprot.org/uniprot/M0IVX1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS06825 ^@ http://purl.uniprot.org/uniprot/I3R2M2 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type-I 3-dehydroquinase family.|||Homodimer.|||Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS04635 ^@ http://purl.uniprot.org/uniprot/I3R1D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS10825 ^@ http://purl.uniprot.org/uniprot/I3R4V5 ^@ Similarity ^@ Belongs to the class II fructose-bisphosphate aldolase family. http://togogenome.org/gene/523841:E6P09_RS02060 ^@ http://purl.uniprot.org/uniprot/I3R5W2 ^@ Similarity ^@ Belongs to the ETF alpha-subunit/FixB family. http://togogenome.org/gene/523841:E6P09_RS08475 ^@ http://purl.uniprot.org/uniprot/I3R3J5 ^@ Similarity ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/523841:E6P09_RS11885 ^@ http://purl.uniprot.org/uniprot/I3R5G5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/523841:E6P09_RS03575 ^@ http://purl.uniprot.org/uniprot/I3R0S8 ^@ Similarity|||Subunit ^@ Belongs to the ALAD family.|||Homooctamer. http://togogenome.org/gene/523841:E6P09_RS14830 ^@ http://purl.uniprot.org/uniprot/I3R768 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family. RadB subfamily.|||Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. http://togogenome.org/gene/523841:E6P09_RS18655 ^@ http://purl.uniprot.org/uniprot/I3R9J2 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/523841:E6P09_RS13165 ^@ http://purl.uniprot.org/uniprot/I3R840 ^@ Similarity ^@ Belongs to the archease family. http://togogenome.org/gene/523841:E6P09_RS05155 ^@ http://purl.uniprot.org/uniprot/I3R1P3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS08110 ^@ http://purl.uniprot.org/uniprot/M0J4X5 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/523841:E6P09_RS03480 ^@ http://purl.uniprot.org/uniprot/I3R0Q9 ^@ Function|||Similarity ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. http://togogenome.org/gene/523841:E6P09_RS15055 ^@ http://purl.uniprot.org/uniprot/M0IS95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily.|||Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS13030 ^@ http://purl.uniprot.org/uniprot/I3R866 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/523841:E6P09_RS06030 ^@ http://purl.uniprot.org/uniprot/I3R263 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS06280 ^@ http://purl.uniprot.org/uniprot/I3R2B0 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/523841:E6P09_RS00970 ^@ http://purl.uniprot.org/uniprot/A0A4P8P1H3 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/523841:E6P09_RS01205 ^@ http://purl.uniprot.org/uniprot/I3R6C8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the archaeosine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs. http://togogenome.org/gene/523841:E6P09_RS16970 ^@ http://purl.uniprot.org/uniprot/I3RAN8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS00290 ^@ http://purl.uniprot.org/uniprot/I3R6V6 ^@ Similarity ^@ Belongs to the Ahb/Nir family. http://togogenome.org/gene/523841:E6P09_RS01985 ^@ http://purl.uniprot.org/uniprot/I3R5X9 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the thiamine-monophosphate kinase family.|||Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. http://togogenome.org/gene/523841:E6P09_RS05150 ^@ http://purl.uniprot.org/uniprot/I3R1P2 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/523841:E6P09_RS18480 ^@ http://purl.uniprot.org/uniprot/I3R9F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523841:E6P09_RS13350 ^@ http://purl.uniprot.org/uniprot/I3R803 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the thiamine-phosphate synthase family.|||Binds 1 Mg(2+) ion per subunit.|||Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). http://togogenome.org/gene/523841:E6P09_RS03055 ^@ http://purl.uniprot.org/uniprot/A0A059TMH9 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/523841:E6P09_RS18535 ^@ http://purl.uniprot.org/uniprot/I3R9G8 ^@ Similarity ^@ Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family. http://togogenome.org/gene/523841:E6P09_RS12415 ^@ http://purl.uniprot.org/uniprot/I3R8I4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.|||Monomer.|||The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity. http://togogenome.org/gene/523841:E6P09_RS19090 ^@ http://purl.uniprot.org/uniprot/I3R932 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS11210 ^@ http://purl.uniprot.org/uniprot/I3R530 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/523841:E6P09_RS13775 ^@ http://purl.uniprot.org/uniprot/I3R7R9 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. http://togogenome.org/gene/523841:E6P09_RS05785 ^@ http://purl.uniprot.org/uniprot/I3R213 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/523841:E6P09_RS14870 ^@ http://purl.uniprot.org/uniprot/I3R760 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/523841:E6P09_RS06725 ^@ http://purl.uniprot.org/uniprot/I3R2K2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS16205 ^@ http://purl.uniprot.org/uniprot/I3RB54 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS08195 ^@ http://purl.uniprot.org/uniprot/I3R3D7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS03145 ^@ http://purl.uniprot.org/uniprot/I3R0J5 ^@ Function|||Similarity ^@ Belongs to the archaeal IMP cyclohydrolase family.|||Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP. http://togogenome.org/gene/523841:E6P09_RS13960 ^@ http://purl.uniprot.org/uniprot/I3R7N5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.|||Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS08050 ^@ http://purl.uniprot.org/uniprot/I3R3B0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS09250 ^@ http://purl.uniprot.org/uniprot/I3R401 ^@ Similarity ^@ Belongs to the SCO1/2 family. http://togogenome.org/gene/523841:E6P09_RS07115 ^@ http://purl.uniprot.org/uniprot/I3R2S9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/523841:E6P09_RS17955 ^@ http://purl.uniprot.org/uniprot/I3R9Y6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS12295 ^@ http://purl.uniprot.org/uniprot/I3R8K8 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the GatB/GatE family. GatE subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/523841:E6P09_RS01285 ^@ http://purl.uniprot.org/uniprot/I3R6B4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyltransferase superfamily. TrmY family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs. http://togogenome.org/gene/523841:E6P09_RS03130 ^@ http://purl.uniprot.org/uniprot/I3R0J2 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/523841:E6P09_RS00980 ^@ http://purl.uniprot.org/uniprot/I3R6H2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS10660 ^@ http://purl.uniprot.org/uniprot/I3R4S2 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/523841:E6P09_RS04945 ^@ http://purl.uniprot.org/uniprot/I3R1K0 ^@ Function|||Similarity ^@ Belongs to the FAU-1 family.|||Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences. http://togogenome.org/gene/523841:E6P09_RS13100 ^@ http://purl.uniprot.org/uniprot/I3R851 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.|||Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.|||Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS08690 ^@ http://purl.uniprot.org/uniprot/I3R3P0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS02115 ^@ http://purl.uniprot.org/uniprot/A0A059TWI9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS18985 ^@ http://purl.uniprot.org/uniprot/M0IP42 ^@ Caution ^@ The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/523841:E6P09_RS02850 ^@ http://purl.uniprot.org/uniprot/I3R8T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS16725 ^@ http://purl.uniprot.org/uniprot/I3RAU3 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/523841:E6P09_RS15130 ^@ http://purl.uniprot.org/uniprot/I3RAF0 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/523841:E6P09_RS03100 ^@ http://purl.uniprot.org/uniprot/I3R0I6 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/523841:E6P09_RS16085 ^@ http://purl.uniprot.org/uniprot/I3RB83 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/523841:E6P09_RS03770 ^@ http://purl.uniprot.org/uniprot/I3R0W9 ^@ Similarity ^@ Belongs to the UPF0201 family. http://togogenome.org/gene/523841:E6P09_RS07885 ^@ http://purl.uniprot.org/uniprot/I3R376 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS02620 ^@ http://purl.uniprot.org/uniprot/I3R8P2 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/523841:E6P09_RS07650 ^@ http://purl.uniprot.org/uniprot/I3R331 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/523841:E6P09_RS05670 ^@ http://purl.uniprot.org/uniprot/I3R1Z1 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/523841:E6P09_RS04625 ^@ http://purl.uniprot.org/uniprot/I3R1D6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm|||Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.|||Heterodimer of two subunits, one of which binds GTP. http://togogenome.org/gene/523841:E6P09_RS06720 ^@ http://purl.uniprot.org/uniprot/A0A4P8P7U9 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/523841:E6P09_RS11015 ^@ http://purl.uniprot.org/uniprot/I3R4Z2 ^@ Similarity ^@ Belongs to the CutA family. http://togogenome.org/gene/523841:E6P09_RS14035 ^@ http://purl.uniprot.org/uniprot/I3R7M0 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/523841:E6P09_RS15490 ^@ http://purl.uniprot.org/uniprot/I3RA77 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS14995 ^@ http://purl.uniprot.org/uniprot/I3R734 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase IV family.|||Binds 1 Fe(2+) ion per subunit.|||Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS18210 ^@ http://purl.uniprot.org/uniprot/I3RA42 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS04450 ^@ http://purl.uniprot.org/uniprot/I3R1A2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS04755 ^@ http://purl.uniprot.org/uniprot/I3R1G0 ^@ Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Part of the RNA polymerase complex. http://togogenome.org/gene/523841:E6P09_RS10050 ^@ http://purl.uniprot.org/uniprot/I3R4F5 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/523841:E6P09_RS11735 ^@ http://purl.uniprot.org/uniprot/I3R5D6 ^@ Function|||PTM|||Similarity ^@ An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.|||Belongs to the polyphosphate kinase 1 (PPK1) family.|||Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). http://togogenome.org/gene/523841:E6P09_RS01580 ^@ http://purl.uniprot.org/uniprot/I3R655 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/523841:E6P09_RS05610 ^@ http://purl.uniprot.org/uniprot/I3R1Y0 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Monomer. http://togogenome.org/gene/523841:E6P09_RS09420 ^@ http://purl.uniprot.org/uniprot/I3R435 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/523841:E6P09_RS03825 ^@ http://purl.uniprot.org/uniprot/I3R0X7 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. http://togogenome.org/gene/523841:E6P09_RS01325 ^@ http://purl.uniprot.org/uniprot/I3R6A7 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/523841:E6P09_RS12615 ^@ http://purl.uniprot.org/uniprot/I3R8E3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS11450 ^@ http://purl.uniprot.org/uniprot/I3R582 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/523841:E6P09_RS18520 ^@ http://purl.uniprot.org/uniprot/I3R9G5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. http://togogenome.org/gene/523841:E6P09_RS05210 ^@ http://purl.uniprot.org/uniprot/I3R1Q3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS07930 ^@ http://purl.uniprot.org/uniprot/I3R385 ^@ Similarity ^@ Belongs to the complex I 20 kDa subunit family. http://togogenome.org/gene/523841:E6P09_RS08015 ^@ http://purl.uniprot.org/uniprot/I3R3A3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS16360 ^@ http://purl.uniprot.org/uniprot/I3RB24 ^@ Similarity ^@ In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/523841:E6P09_RS12915 ^@ http://purl.uniprot.org/uniprot/I3R889 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS02480 ^@ http://purl.uniprot.org/uniprot/M0ISZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/523841:E6P09_RS04730 ^@ http://purl.uniprot.org/uniprot/I3R1F7 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.|||Cell membrane|||Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Membrane|||Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function. http://togogenome.org/gene/523841:E6P09_RS06815 ^@ http://purl.uniprot.org/uniprot/I3R2M0 ^@ Function|||Similarity ^@ Belongs to the archaeal-type DHQ synthase family.|||Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis. http://togogenome.org/gene/523841:E6P09_RS15505 ^@ http://purl.uniprot.org/uniprot/I3RA74 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS05760 ^@ http://purl.uniprot.org/uniprot/I3R208 ^@ Similarity ^@ Belongs to the transcriptional regulator TrmB family. http://togogenome.org/gene/523841:E6P09_RS06155 ^@ http://purl.uniprot.org/uniprot/I3R287 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/523841:E6P09_RS14280 ^@ http://purl.uniprot.org/uniprot/I3R7H2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS03195 ^@ http://purl.uniprot.org/uniprot/I3R0K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523841:E6P09_RS12990 ^@ http://purl.uniprot.org/uniprot/I3R874 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/523841:E6P09_RS10990 ^@ http://purl.uniprot.org/uniprot/I3R4Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS17435 ^@ http://purl.uniprot.org/uniprot/I3R9M7 ^@ Cofactor|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.|||Cell membrane|||Probable multiprotein complex; a catalytic heterodimer of an alpha and beta chain is proposed to associate with additional subunits involved in membrane attachment and electron transfer.|||The respiratory membrane-bound nitrate reductase enzyme complex plays a role in generation of metabolic energy by using nitrate as a terminal electron acceptor during anaerobic conditions. May transfer electrons to the iron-sulfur centers of the catalytic beta subunit. http://togogenome.org/gene/523841:E6P09_RS04350 ^@ http://purl.uniprot.org/uniprot/I3R180 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS08620 ^@ http://purl.uniprot.org/uniprot/I3R3M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/523841:E6P09_RS07210 ^@ http://purl.uniprot.org/uniprot/I3R2U8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS07245 ^@ http://purl.uniprot.org/uniprot/I3R2V5 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/523841:E6P09_RS16195 ^@ http://purl.uniprot.org/uniprot/I3RB57 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/523841:E6P09_RS05145 ^@ http://purl.uniprot.org/uniprot/I3R1P1 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/523841:E6P09_RS12035 ^@ http://purl.uniprot.org/uniprot/M0J587 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/523841:E6P09_RS18395 ^@ http://purl.uniprot.org/uniprot/I3R9D8 ^@ Similarity ^@ Belongs to the aspartate/glutamate racemases family. http://togogenome.org/gene/523841:E6P09_RS03120 ^@ http://purl.uniprot.org/uniprot/I3R0J0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS14885 ^@ http://purl.uniprot.org/uniprot/I3R757 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/523841:E6P09_RS18605 ^@ http://purl.uniprot.org/uniprot/I3R9I2 ^@ Similarity ^@ Belongs to the Mg-chelatase subunits D/I family. http://togogenome.org/gene/523841:E6P09_RS07185 ^@ http://purl.uniprot.org/uniprot/I3R2U3 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/523841:E6P09_RS11510 ^@ http://purl.uniprot.org/uniprot/Q02230 ^@ Activity Regulation|||Function|||Induction|||Miscellaneous|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Encoded in a 14-gene locus called mc-vac.|||Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.|||Interacts with GvpD, also with c-GvpD from H.salinarum.|||Plays a regulatory role in gas vesicle synthesis, activates transcription of the gvpA operon, and probably of the gvpD operon (Probable) (PubMed:12864859). Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat (By similarity).|||The amount of protein that accumulates is controlled by GvpD; GvpD causes a reduction in the amount of GvpE, preventing accumulation of excessive amounts of gas vesicles.|||Transcribed from mid-log to stationary phase, probably as a gvpD-gvpM RNA (PubMed:1404376). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt at 15% salt (PubMed:8757736). Accumulates in late exponential to stationary phase (at protein level) (PubMed:12864859). http://togogenome.org/gene/523841:E6P09_RS04025 ^@ http://purl.uniprot.org/uniprot/I3R115 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS19145 ^@ http://purl.uniprot.org/uniprot/I3R943 ^@ Similarity ^@ Belongs to the peptidase S33 family. http://togogenome.org/gene/523841:E6P09_RS09770 ^@ http://purl.uniprot.org/uniprot/I3R4A1 ^@ Function|||Similarity ^@ Belongs to the archaeal-type GTP cyclohydrolase family.|||Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity. http://togogenome.org/gene/523841:E6P09_RS13565 ^@ http://purl.uniprot.org/uniprot/I3R7W0 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/523841:E6P09_RS17850 ^@ http://purl.uniprot.org/uniprot/I3R9W4 ^@ Similarity ^@ Belongs to the 3-oxoacid CoA-transferase family. http://togogenome.org/gene/523841:E6P09_RS11490 ^@ http://purl.uniprot.org/uniprot/M0J616|||http://purl.uniprot.org/uniprot/Q02239 ^@ Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An ATPase that functions in gas vesicle formation (By similarity). A minor component of the gas vesicle, also found in soluble extracts (By similarity). Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat (By similarity).|||Belongs to the CbbQ/NirQ/NorQ/GpvN family.|||Cytoplasm|||Encoded in a 14-gene locus called mc-vac.|||Expressed from a single promoter upstream of gvpA; most transcripts stop at the gvpA terminator, with low read-through into downstream gvpC-gvpN-gvpO. Expression starts in early stationary phase and is maximal in stationary phase (PubMed:7683649, PubMed:8757736). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736).|||Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.|||Forms homodimers, a GvpN-GvpO heterodimer, interacts with GvpC and GvpL, might interact with GvpA.|||Gas vesicle|||Vesicle http://togogenome.org/gene/523841:E6P09_RS18040 ^@ http://purl.uniprot.org/uniprot/I3RA05 ^@ Function|||Similarity ^@ Belongs to the deoxyhypusine synthase family.|||Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. http://togogenome.org/gene/523841:E6P09_RS06410 ^@ http://purl.uniprot.org/uniprot/I3R2D6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS03840 ^@ http://purl.uniprot.org/uniprot/I3R0X9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS11460 ^@ http://purl.uniprot.org/uniprot/I3R584 ^@ Cofactor|||Disruption Phenotype|||Function|||Induction|||Similarity|||Subunit ^@ Belongs to the glutamine synthetase family.|||Binds 2 Mg(2+) ions per subunit.|||Dodecamer.|||Expression is induced in complex medium (CM) in which putrescine is both nitrogen (N) and carbon (C) source, in defined media (DM) with putrescine as the N source and glucose as the C source, DM with ammonium or nitrate as the N source and glucose as the C source, and in nitrogen starvation media (NS) without the N source and glucose as the C source (at protein level). Not expressed in CM in which yeast extract is both the N and the C source (at protein level). Constitutively expressed at different growth phases in CM in which yeast extract is both the N and the C source and in DM with ammonium or nitrate as the N source and glucose as the C source. Also constitutively expressed in NS regardless of the nitrogen deficiency time (48, 96 or 120 hours). Expression may be regulated at post-transcriptional level (PubMed:34439822). Expression is down-regulated in CM with 40 mM glutamine in the mid-exponential phase after nitrogen starvation for 72 hours (PubMed:32296946).|||Involved in the breakdown of putrescine via the biosynthesis of gamma-L-glutamylputrescine. Not required for glutamine synthesis (PubMed:34439822). Is not able to compensate for the loss of glutamine synthetase (PubMed:32296946).|||No glutamate-putrescine ligase activity in complex medium (CM) in which putrescine is both nitrogen (N) and carbon (C) source, in defined media (DM) with putrescine as the N source and glucose as the C source nor in DM with nitrate as the N source and glucose as the C source. http://togogenome.org/gene/523841:E6P09_RS06970 ^@ http://purl.uniprot.org/uniprot/I3R2Q1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DtxR/MntR family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS10360 ^@ http://purl.uniprot.org/uniprot/I3R4L5 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/523841:E6P09_RS10460 ^@ http://purl.uniprot.org/uniprot/I3R4N5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/523841:E6P09_RS01290 ^@ http://purl.uniprot.org/uniprot/I3R6B3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS08615 ^@ http://purl.uniprot.org/uniprot/I3R3M4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||S-layer http://togogenome.org/gene/523841:E6P09_RS09945 ^@ http://purl.uniprot.org/uniprot/I3R4D4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/523841:E6P09_RS12700 ^@ http://purl.uniprot.org/uniprot/I3R8C7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS11495 ^@ http://purl.uniprot.org/uniprot/Q02228 ^@ Function|||Induction|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the halobacterial gas vesicle GvpC family.|||Confers stability, involved in shaping gas vesicles (GV), hollow, gas filled proteinaceous nanostructures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat.|||Detected as 2 slightly different sizes in vivo; the proteins appears larger in SDS-PAGE probably due to the acidic tail.|||Encoded in a 14-gene locus called mc-vac.|||Expressed from a single promoter upstream of gvpA; most transcripts stop at the gvpA terminator, with low read-through into downstream gvpC-gvpN-gvpO. Expression starts in early stationary phase and is maximal in stationary phase (PubMed:7683649, PubMed:8757736). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736).|||Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.|||Gas vesicle http://togogenome.org/gene/523841:E6P09_RS10630 ^@ http://purl.uniprot.org/uniprot/I3R4R6 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.|||Heterooligomer of catalytic and regulatory chains. http://togogenome.org/gene/523841:E6P09_RS13255 ^@ http://purl.uniprot.org/uniprot/I3R823 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS11235 ^@ http://purl.uniprot.org/uniprot/I3R535 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/523841:E6P09_RS10285 ^@ http://purl.uniprot.org/uniprot/I3R4K1 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/523841:E6P09_RS08890 ^@ http://purl.uniprot.org/uniprot/I3R3S7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatA/E family.|||Cell membrane|||Forms a complex with TatC.|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. http://togogenome.org/gene/523841:E6P09_RS02030 ^@ http://purl.uniprot.org/uniprot/I3R5W9 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/523841:E6P09_RS16275 ^@ http://purl.uniprot.org/uniprot/I3RB42 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. HutI family.|||Binds 1 zinc or iron ion per subunit.|||Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS08775 ^@ http://purl.uniprot.org/uniprot/I3R3Q8 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/523841:E6P09_RS18835 ^@ http://purl.uniprot.org/uniprot/I3R9C3 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/523841:E6P09_RS00105 ^@ http://purl.uniprot.org/uniprot/I3R6Z0 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/523841:E6P09_RS17590 ^@ http://purl.uniprot.org/uniprot/I3R9R2 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/523841:E6P09_RS01440 ^@ http://purl.uniprot.org/uniprot/I3R684 ^@ Similarity ^@ Belongs to the PdaD family. http://togogenome.org/gene/523841:E6P09_RS13280 ^@ http://purl.uniprot.org/uniprot/I3R818 ^@ Similarity ^@ Belongs to the MscS (TC 1.A.23) family. http://togogenome.org/gene/523841:E6P09_RS18430 ^@ http://purl.uniprot.org/uniprot/I3R9E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523841:E6P09_RS14610 ^@ http://purl.uniprot.org/uniprot/I3R7B2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcL subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/523841:E6P09_RS18290 ^@ http://purl.uniprot.org/uniprot/A0A059TYL5 ^@ Function ^@ Part of a potassium transport system. http://togogenome.org/gene/523841:E6P09_RS09865 ^@ http://purl.uniprot.org/uniprot/I3R4B8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DNA polymerase type-Y family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Monomer.|||Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. http://togogenome.org/gene/523841:E6P09_RS16585 ^@ http://purl.uniprot.org/uniprot/M0IML6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS00300 ^@ http://purl.uniprot.org/uniprot/M0IVM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS10475 ^@ http://purl.uniprot.org/uniprot/I3R4N8 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/523841:E6P09_RS13195 ^@ http://purl.uniprot.org/uniprot/I3R836 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/523841:E6P09_RS13220 ^@ http://purl.uniprot.org/uniprot/I3R831 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/523841:E6P09_RS13475 ^@ http://purl.uniprot.org/uniprot/I3R7X6 ^@ Similarity ^@ Belongs to the PspA/IM30 family. http://togogenome.org/gene/523841:E6P09_RS06755 ^@ http://purl.uniprot.org/uniprot/I3R2K8 ^@ Function ^@ Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. http://togogenome.org/gene/523841:E6P09_RS04220 ^@ http://purl.uniprot.org/uniprot/I3R153 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BioY family.|||Cell membrane http://togogenome.org/gene/523841:E6P09_RS12255 ^@ http://purl.uniprot.org/uniprot/I3R8L5 ^@ Function|||Similarity ^@ Belongs to the archaeal 6-HMPDK family.|||Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP). http://togogenome.org/gene/523841:E6P09_RS05515 ^@ http://purl.uniprot.org/uniprot/I3R1W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal histone HMF family.|||Chromosome|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS04365 ^@ http://purl.uniprot.org/uniprot/I3R185 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Potential transporter for phosphate. http://togogenome.org/gene/523841:E6P09_RS03900 ^@ http://purl.uniprot.org/uniprot/I3R0Z1 ^@ Caution|||Function|||Similarity ^@ Belongs to the TBP family.|||General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS01465 ^@ http://purl.uniprot.org/uniprot/I3R679 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS02700 ^@ http://purl.uniprot.org/uniprot/I3R8Q8 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/523841:E6P09_RS00190 ^@ http://purl.uniprot.org/uniprot/I3R6X4 ^@ Similarity ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family. http://togogenome.org/gene/523841:E6P09_RS12400 ^@ http://purl.uniprot.org/uniprot/I3R8I7 ^@ Function|||Similarity|||Subunit ^@ Associates with stalled 50S ribosomal subunits.|||Belongs to the NEMF family.|||Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation. http://togogenome.org/gene/523841:E6P09_RS16080 ^@ http://purl.uniprot.org/uniprot/I3RB84 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/523841:E6P09_RS12765 ^@ http://purl.uniprot.org/uniprot/I3R8B6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS02715 ^@ http://purl.uniprot.org/uniprot/I3R8R1 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/523841:E6P09_RS04370 ^@ http://purl.uniprot.org/uniprot/I3R186 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS05310 ^@ http://purl.uniprot.org/uniprot/I3R1S3 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/523841:E6P09_RS14675 ^@ http://purl.uniprot.org/uniprot/I3R799 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family. http://togogenome.org/gene/523841:E6P09_RS00575 ^@ http://purl.uniprot.org/uniprot/I3R6Q2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS14385 ^@ http://purl.uniprot.org/uniprot/I3R7F2 ^@ Disruption Phenotype|||Function|||Subunit ^@ Cells lacking pccB and pccX genes accumulate a high level of propionyl-CoA, which would then inhibit CoA-dependent enzymes such as succinyl-CoA synthetase and could partially inhibit the TCA cycle. Also affected in growth and glucose utilization. Cells are unable to produce PHBV and show morphological abnormalitiess such as a decrease of PHBV granules.|||Part of the propionyl coenzyme A carboxylase (PCC) complex involved in propionate utilization and in the production of the poly(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV), which is a water-insoluble biopolymer used as intracellular energy reserve material when cells grow under conditions of nutrient limitation. The complex catalyzes the carboxylation of propionyl-CoA to methylmalonyl-CoA. PCC is also able to catalyze the carboxylation of acetyl-CoA. PccX could be responsible for the interaction of the biotin carboxylase and carboxyltransferase subunits.|||The propionyl coenzyme A carboxylase (PCC) complex is composed of three subunits: PccA (biotin carboxylase and biotin-carboxyl carrier), PccB (carboxyltransferase) and PccX. http://togogenome.org/gene/523841:E6P09_RS06740 ^@ http://purl.uniprot.org/uniprot/I3R2K5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.|||Belongs to the peptidase S16 family. Archaeal LonB subfamily.|||Cell membrane|||Homohexamer. Organized in a ring with a central cavity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/523841:E6P09_RS05090 ^@ http://purl.uniprot.org/uniprot/I3R1N0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL40 family. http://togogenome.org/gene/523841:E6P09_RS05455 ^@ http://purl.uniprot.org/uniprot/I3R1V2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS12465 ^@ http://purl.uniprot.org/uniprot/M0INC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS13735 ^@ http://purl.uniprot.org/uniprot/I3R7S7 ^@ Similarity ^@ Belongs to the HMG-CoA reductase family. http://togogenome.org/gene/523841:E6P09_RS05165 ^@ http://purl.uniprot.org/uniprot/I3R1P5 ^@ Caution|||Function|||Similarity ^@ Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.|||Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS12855 ^@ http://purl.uniprot.org/uniprot/I3R8A0 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/523841:E6P09_RS10635 ^@ http://purl.uniprot.org/uniprot/I3R4R7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrI family.|||Binds 1 zinc ion per subunit.|||Contains catalytic and regulatory chains.|||Involved in allosteric regulation of aspartate carbamoyltransferase. http://togogenome.org/gene/523841:E6P09_RS06895 ^@ http://purl.uniprot.org/uniprot/I3R2N6 ^@ Similarity ^@ Belongs to the pyruvate kinase family.|||In the C-terminal section; belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/523841:E6P09_RS12285 ^@ http://purl.uniprot.org/uniprot/M0IQN4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/523841:E6P09_RS05070 ^@ http://purl.uniprot.org/uniprot/I3R1M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA-PH family.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS13710 ^@ http://purl.uniprot.org/uniprot/I3R7T1 ^@ Cofactor ^@ Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/523841:E6P09_RS07445 ^@ http://purl.uniprot.org/uniprot/I3R2Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the halobacterial S-layer protein family.|||Cell membrane|||Membrane|||S-layer http://togogenome.org/gene/523841:E6P09_RS06170 ^@ http://purl.uniprot.org/uniprot/I3R290 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL43 family.|||Binds to the 23S rRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/523841:E6P09_RS06255 ^@ http://purl.uniprot.org/uniprot/I3R2A6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GGGP/HepGP synthase family. Group I subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/523841:E6P09_RS14845 ^@ http://purl.uniprot.org/uniprot/I3R765 ^@ Similarity ^@ Belongs to the LarC family. http://togogenome.org/gene/523841:E6P09_RS06735 ^@ http://purl.uniprot.org/uniprot/I3R2K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal NMN adenylyltransferase family.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS05525 ^@ http://purl.uniprot.org/uniprot/I3R1W6 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A single active site specifically recognizes both ATP and CTP and is responsible for their addition.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.|||Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS06775 ^@ http://purl.uniprot.org/uniprot/I3R2L2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.|||Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.|||Homodecamer. http://togogenome.org/gene/523841:E6P09_RS03060 ^@ http://purl.uniprot.org/uniprot/I3R8X9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrC family.|||Cytoplasm|||Interacts with UvrB in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. http://togogenome.org/gene/523841:E6P09_RS02770 ^@ http://purl.uniprot.org/uniprot/I3R8S1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS19095 ^@ http://purl.uniprot.org/uniprot/I3R933 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS18425 ^@ http://purl.uniprot.org/uniprot/M0J8P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523841:E6P09_RS01635 ^@ http://purl.uniprot.org/uniprot/I3R644 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS15145 ^@ http://purl.uniprot.org/uniprot/I3RAE8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS12215 ^@ http://purl.uniprot.org/uniprot/I3R8M3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS00400 ^@ http://purl.uniprot.org/uniprot/I3R6T7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CofC family.|||Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS06235 ^@ http://purl.uniprot.org/uniprot/I3R2A2 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. PoK subfamily.|||Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway. http://togogenome.org/gene/523841:E6P09_RS16130 ^@ http://purl.uniprot.org/uniprot/I3RB71 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/523841:E6P09_RS10595 ^@ http://purl.uniprot.org/uniprot/I3R4Q9 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FBPase class 1 family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS07920 ^@ http://purl.uniprot.org/uniprot/I3R383 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/523841:E6P09_RS17695 ^@ http://purl.uniprot.org/uniprot/I3R9T6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS06835 ^@ http://purl.uniprot.org/uniprot/I3R2M4 ^@ Function|||Similarity ^@ Belongs to the TFIIB family.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/523841:E6P09_RS02455 ^@ http://purl.uniprot.org/uniprot/I3R5N5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS17190 ^@ http://purl.uniprot.org/uniprot/I3RAJ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS17985 ^@ http://purl.uniprot.org/uniprot/I3R9Z2 ^@ Disruption Phenotype|||Function|||Subcellular Location Annotation ^@ Cytoplasmic granule|||Deletion mutant is defective in both PHA biosynthesis and cell growth. The number of PHA granules is significantly lower.|||Polyhydroxyalkanoate (PHA) granule structural protein. Important for PHA granule formation and separation, and for cell growth. http://togogenome.org/gene/523841:E6P09_RS10280 ^@ http://purl.uniprot.org/uniprot/M0J6F6 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.|||Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA). http://togogenome.org/gene/523841:E6P09_RS16425 ^@ http://purl.uniprot.org/uniprot/I3RB10 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/523841:E6P09_RS10565 ^@ http://purl.uniprot.org/uniprot/I3R4Q3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS10150 ^@ http://purl.uniprot.org/uniprot/I3R4H4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/523841:E6P09_RS01530 ^@ http://purl.uniprot.org/uniprot/I3R665 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/523841:E6P09_RS14205 ^@ http://purl.uniprot.org/uniprot/I3R7I1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS08020 ^@ http://purl.uniprot.org/uniprot/I3R3A4 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/523841:E6P09_RS11075 ^@ http://purl.uniprot.org/uniprot/I3R504 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/523841:E6P09_RS19400 ^@ http://purl.uniprot.org/uniprot/I3R990 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS08535 ^@ http://purl.uniprot.org/uniprot/I3R3K8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 3 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/523841:E6P09_RS15835 ^@ http://purl.uniprot.org/uniprot/I3RBD6 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/523841:E6P09_RS09150 ^@ http://purl.uniprot.org/uniprot/I3R3Y1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS14945 ^@ http://purl.uniprot.org/uniprot/I3R744 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS00055 ^@ http://purl.uniprot.org/uniprot/I3R700 ^@ Similarity ^@ Belongs to the Ahb/Nir family. http://togogenome.org/gene/523841:E6P09_RS00040 ^@ http://purl.uniprot.org/uniprot/I3R703 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/523841:E6P09_RS02855 ^@ http://purl.uniprot.org/uniprot/I3R8T7 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/523841:E6P09_RS08375 ^@ http://purl.uniprot.org/uniprot/I3R3H5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS11685 ^@ http://purl.uniprot.org/uniprot/I3R5C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS14210 ^@ http://purl.uniprot.org/uniprot/I3R7I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 2 subfamily.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS04615 ^@ http://purl.uniprot.org/uniprot/I3R1D4 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/523841:E6P09_RS00850 ^@ http://purl.uniprot.org/uniprot/I3R6J6 ^@ Caution|||Function|||Similarity ^@ Belongs to the TBP family.|||General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS13685 ^@ http://purl.uniprot.org/uniprot/I3R7T6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/523841:E6P09_RS02415 ^@ http://purl.uniprot.org/uniprot/I3R5P3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS13245 ^@ http://purl.uniprot.org/uniprot/A0A059TPQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523841:E6P09_RS07790 ^@ http://purl.uniprot.org/uniprot/I3R357 ^@ Similarity ^@ Belongs to the beta-class carbonic anhydrase family. http://togogenome.org/gene/523841:E6P09_RS15940 ^@ http://purl.uniprot.org/uniprot/I3RBB3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS13570 ^@ http://purl.uniprot.org/uniprot/I3R7V9 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS02055 ^@ http://purl.uniprot.org/uniprot/I3R5W3 ^@ Similarity ^@ Belongs to the ETF beta-subunit/FixA family. http://togogenome.org/gene/523841:E6P09_RS13940 ^@ http://purl.uniprot.org/uniprot/I3R7N9 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Part of the 30S ribosomal subunit. Contacts protein S4.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/523841:E6P09_RS13355 ^@ http://purl.uniprot.org/uniprot/I3R802 ^@ Function|||Similarity ^@ Belongs to the Thz kinase family.|||Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ). http://togogenome.org/gene/523841:E6P09_RS08870 ^@ http://purl.uniprot.org/uniprot/I3R3S4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS00270 ^@ http://purl.uniprot.org/uniprot/I3R6W0 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/523841:E6P09_RS17005 ^@ http://purl.uniprot.org/uniprot/I3RAN1 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.|||In the C-terminal section; belongs to the NAD synthetase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS04150 ^@ http://purl.uniprot.org/uniprot/I3R139 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS09740 ^@ http://purl.uniprot.org/uniprot/I3R495 ^@ Similarity ^@ Belongs to the dihydrofolate reductase family. http://togogenome.org/gene/523841:E6P09_RS17090 ^@ http://purl.uniprot.org/uniprot/I3RAL4 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/523841:E6P09_RS02610 ^@ http://purl.uniprot.org/uniprot/M0J1V2 ^@ Similarity ^@ Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. http://togogenome.org/gene/523841:E6P09_RS10750 ^@ http://purl.uniprot.org/uniprot/I3R4U0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS13950 ^@ http://purl.uniprot.org/uniprot/I3R7N7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/523841:E6P09_RS00900 ^@ http://purl.uniprot.org/uniprot/I3R6I6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS07880 ^@ http://purl.uniprot.org/uniprot/I3R375 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.|||Belongs to the RuBisCO large chain family. Type III subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.|||Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits. http://togogenome.org/gene/523841:E6P09_RS08370 ^@ http://purl.uniprot.org/uniprot/I3R3H4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS02410 ^@ http://purl.uniprot.org/uniprot/I3R5P4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS10855 ^@ http://purl.uniprot.org/uniprot/I3R4W1 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/523841:E6P09_RS14195 ^@ http://purl.uniprot.org/uniprot/I3R7I4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS13945 ^@ http://purl.uniprot.org/uniprot/I3R7N8 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/523841:E6P09_RS18920 ^@ http://purl.uniprot.org/uniprot/I3R8Z8 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/523841:E6P09_RS02285 ^@ http://purl.uniprot.org/uniprot/I3R5R7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/523841:E6P09_RS10365 ^@ http://purl.uniprot.org/uniprot/I3R4L6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/523841:E6P09_RS04110 ^@ http://purl.uniprot.org/uniprot/I3R131 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/523841:E6P09_RS03935 ^@ http://purl.uniprot.org/uniprot/I3R0Z8 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS09925 ^@ http://purl.uniprot.org/uniprot/I3R4D0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/523841:E6P09_RS11645 ^@ http://purl.uniprot.org/uniprot/I3R5C0 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/523841:E6P09_RS08045 ^@ http://purl.uniprot.org/uniprot/I3R3A9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS12815 ^@ http://purl.uniprot.org/uniprot/I3R8A7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/523841:E6P09_RS10135 ^@ http://purl.uniprot.org/uniprot/I3R4H2 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/523841:E6P09_RS18720 ^@ http://purl.uniprot.org/uniprot/I3R9K5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/523841:E6P09_RS12935 ^@ http://purl.uniprot.org/uniprot/I3R885 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. Probably involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.|||Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA. http://togogenome.org/gene/523841:E6P09_RS18915 ^@ http://purl.uniprot.org/uniprot/I3R8Z7 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/523841:E6P09_RS12925 ^@ http://purl.uniprot.org/uniprot/I3R887 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/523841:E6P09_RS00005 ^@ http://purl.uniprot.org/uniprot/I3R710 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS04590 ^@ http://purl.uniprot.org/uniprot/I3R1C9 ^@ Function|||Similarity ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/523841:E6P09_RS18730 ^@ http://purl.uniprot.org/uniprot/I3R9K7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS03395 ^@ http://purl.uniprot.org/uniprot/I3R0P3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS05600 ^@ http://purl.uniprot.org/uniprot/I3R1X8 ^@ Similarity ^@ Belongs to the aconitase/IPM isomerase family. http://togogenome.org/gene/523841:E6P09_RS14400 ^@ http://purl.uniprot.org/uniprot/I3R7E9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS10575 ^@ http://purl.uniprot.org/uniprot/I3R4Q5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS12070 ^@ http://purl.uniprot.org/uniprot/I3R5K3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the QueC family.|||Binds 1 zinc ion per subunit.|||Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). http://togogenome.org/gene/523841:E6P09_RS03560 ^@ http://purl.uniprot.org/uniprot/B8ZYW3 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Expressed during ammonium starvation under nitrate-rich conditions.|||Homotrimer (By similarity). Interacts with both GlnK1 and GlnK2 after ammonium shock (By similarity).|||Involved in the uptake of ammonium/ammonia (NH(4)(+)/NH(3)) (By similarity). Transport is electrogenic (By similarity). http://togogenome.org/gene/523841:E6P09_RS00310 ^@ http://purl.uniprot.org/uniprot/I3R6V2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS15015 ^@ http://purl.uniprot.org/uniprot/I3R731 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/523841:E6P09_RS00065 ^@ http://purl.uniprot.org/uniprot/I3R6Z8 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/523841:E6P09_RS18680 ^@ http://purl.uniprot.org/uniprot/I3R9J7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Membrane|||Part of an ABC transporter complex. Responsible for energy coupling to the transport system.|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/523841:E6P09_RS10035 ^@ http://purl.uniprot.org/uniprot/I3R4F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS12570 ^@ http://purl.uniprot.org/uniprot/I3R8F2 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/523841:E6P09_RS14135 ^@ http://purl.uniprot.org/uniprot/I3R7J6 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the asparaginase 1 family. GatD subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/523841:E6P09_RS04675 ^@ http://purl.uniprot.org/uniprot/I3R1E6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-archaeol synthase family.|||Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.|||Cell membrane http://togogenome.org/gene/523841:E6P09_RS12500 ^@ http://purl.uniprot.org/uniprot/I3R8G6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS12660 ^@ http://purl.uniprot.org/uniprot/I3R8D5 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. http://togogenome.org/gene/523841:E6P09_RS11825 ^@ http://purl.uniprot.org/uniprot/I3R5F4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic CoaD family.|||Cytoplasm|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/523841:E6P09_RS17035 ^@ http://purl.uniprot.org/uniprot/I3RAM5 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/523841:E6P09_RS08625 ^@ http://purl.uniprot.org/uniprot/I3R3M6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS10165 ^@ http://purl.uniprot.org/uniprot/M0J4T2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Belongs to the NnrE/AIBP family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Homotetramer.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS12020 ^@ http://purl.uniprot.org/uniprot/I3R5J2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS11445 ^@ http://purl.uniprot.org/uniprot/I3R581 ^@ Similarity ^@ Belongs to the Dps family. http://togogenome.org/gene/523841:E6P09_RS11150 ^@ http://purl.uniprot.org/uniprot/I3R519 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/523841:E6P09_RS01065 ^@ http://purl.uniprot.org/uniprot/M0IVE2 ^@ Subcellular Location Annotation ^@ chloroplast http://togogenome.org/gene/523841:E6P09_RS18705 ^@ http://purl.uniprot.org/uniprot/I3R9K2 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/523841:E6P09_RS13530 ^@ http://purl.uniprot.org/uniprot/I3R7W7 ^@ Similarity ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. http://togogenome.org/gene/523841:E6P09_RS08310 ^@ http://purl.uniprot.org/uniprot/I3R3G1 ^@ Function ^@ Part of a potassium transport system. http://togogenome.org/gene/523841:E6P09_RS03250 ^@ http://purl.uniprot.org/uniprot/I3R0L4 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase class-2 family.|||Belongs to the ribonucleoside diphosphate reductase large chain family.|||Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. http://togogenome.org/gene/523841:E6P09_RS05730 ^@ http://purl.uniprot.org/uniprot/I3R202 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/523841:E6P09_RS13925 ^@ http://purl.uniprot.org/uniprot/I3R7P2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/523841:E6P09_RS06165 ^@ http://purl.uniprot.org/uniprot/I3R289 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/523841:E6P09_RS05480 ^@ http://purl.uniprot.org/uniprot/I3R1V7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Catalyzes the NAD-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone.|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS11980 ^@ http://purl.uniprot.org/uniprot/I3R5I4 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/523841:E6P09_RS05650 ^@ http://purl.uniprot.org/uniprot/I3R1Y8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS06465 ^@ http://purl.uniprot.org/uniprot/I3R2E7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/523841:E6P09_RS13325 ^@ http://purl.uniprot.org/uniprot/I3R809 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. http://togogenome.org/gene/523841:E6P09_RS10405 ^@ http://purl.uniprot.org/uniprot/I3R4M4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS16735 ^@ http://purl.uniprot.org/uniprot/I3RAU1 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/523841:E6P09_RS13840 ^@ http://purl.uniprot.org/uniprot/I3R7Q9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e. http://togogenome.org/gene/523841:E6P09_RS13430 ^@ http://purl.uniprot.org/uniprot/I3R7Y5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS00910 ^@ http://purl.uniprot.org/uniprot/I3R6I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523841:E6P09_RS01400 ^@ http://purl.uniprot.org/uniprot/I3R692 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI family.|||Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS16625 ^@ http://purl.uniprot.org/uniprot/I3RAW8 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/523841:E6P09_RS17735 ^@ http://purl.uniprot.org/uniprot/I3R9U4 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/523841:E6P09_RS16990 ^@ http://purl.uniprot.org/uniprot/I3RAN4 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/523841:E6P09_RS00150 ^@ http://purl.uniprot.org/uniprot/I3R6Y2 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/523841:E6P09_RS01525 ^@ http://purl.uniprot.org/uniprot/I3R666 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. http://togogenome.org/gene/523841:E6P09_RS08630 ^@ http://purl.uniprot.org/uniprot/I3R3M7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CetZ family.|||Cytoplasm|||Involved in cell shape control.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS18370 ^@ http://purl.uniprot.org/uniprot/I3R9D2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the spermidine/spermine synthase family.|||Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.|||Cell membrane|||Homodimer or homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS02705 ^@ http://purl.uniprot.org/uniprot/I3R8Q9 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Cytoplasm|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/523841:E6P09_RS00705 ^@ http://purl.uniprot.org/uniprot/I3R6M6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS03000 ^@ http://purl.uniprot.org/uniprot/I3R8W6 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/523841:E6P09_RS15855 ^@ http://purl.uniprot.org/uniprot/I3RBD2 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/523841:E6P09_RS16785 ^@ http://purl.uniprot.org/uniprot/I3RAT1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS14425 ^@ http://purl.uniprot.org/uniprot/I3R7E4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/523841:E6P09_RS13785 ^@ http://purl.uniprot.org/uniprot/I3R7R7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCH family.|||Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS02310 ^@ http://purl.uniprot.org/uniprot/I3R5R2 ^@ Similarity ^@ Belongs to the 2Fe2S plant-type ferredoxin family. http://togogenome.org/gene/523841:E6P09_RS08315 ^@ http://purl.uniprot.org/uniprot/I3R3G2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS12015 ^@ http://purl.uniprot.org/uniprot/I3R5J1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS15455 ^@ http://purl.uniprot.org/uniprot/A0A059TZ36 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/523841:E6P09_RS05300 ^@ http://purl.uniprot.org/uniprot/I3R1S1 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/523841:E6P09_RS14750 ^@ http://purl.uniprot.org/uniprot/I3R784 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/523841:E6P09_RS01345 ^@ http://purl.uniprot.org/uniprot/I3R6A3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/523841:E6P09_RS11260 ^@ http://purl.uniprot.org/uniprot/I3R540 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS00485 ^@ http://purl.uniprot.org/uniprot/I3R6R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AzlC family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS03820 ^@ http://purl.uniprot.org/uniprot/I3R0X6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/523841:E6P09_RS08605 ^@ http://purl.uniprot.org/uniprot/I3R3M2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP19 family.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/523841:E6P09_RS05295 ^@ http://purl.uniprot.org/uniprot/I3R1S0 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/523841:E6P09_RS10400 ^@ http://purl.uniprot.org/uniprot/I3R4M3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS03440 ^@ http://purl.uniprot.org/uniprot/I3R0Q2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS04260 ^@ http://purl.uniprot.org/uniprot/I3R162 ^@ Function|||Similarity ^@ Belongs to the TFIIB family.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/523841:E6P09_RS11690 ^@ http://purl.uniprot.org/uniprot/I3R5C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS12840 ^@ http://purl.uniprot.org/uniprot/I3R8A3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/523841:E6P09_RS05020 ^@ http://purl.uniprot.org/uniprot/I3R1L6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS00340 ^@ http://purl.uniprot.org/uniprot/I3R6U9 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/523841:E6P09_RS16480 ^@ http://purl.uniprot.org/uniprot/I3RB01 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/523841:E6P09_RS00475 ^@ http://purl.uniprot.org/uniprot/I3R6S0 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/523841:E6P09_RS01615 ^@ http://purl.uniprot.org/uniprot/I3R648 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).|||Belongs to the TDD superfamily. TSR3 family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS09885 ^@ http://purl.uniprot.org/uniprot/I3R4C2 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/523841:E6P09_RS14420 ^@ http://purl.uniprot.org/uniprot/I3R7E5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/523841:E6P09_RS08265 ^@ http://purl.uniprot.org/uniprot/I3R3F2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/523841:E6P09_RS18965 ^@ http://purl.uniprot.org/uniprot/I3R908 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/523841:E6P09_RS18475 ^@ http://purl.uniprot.org/uniprot/I3R9F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523841:E6P09_RS04795 ^@ http://purl.uniprot.org/uniprot/I3R1H0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS11195 ^@ http://purl.uniprot.org/uniprot/I3R527 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/523841:E6P09_RS12995 ^@ http://purl.uniprot.org/uniprot/I3R873 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS18465 ^@ http://purl.uniprot.org/uniprot/I3R9F5 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/523841:E6P09_RS13160 ^@ http://purl.uniprot.org/uniprot/I3R841 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Monomer. http://togogenome.org/gene/523841:E6P09_RS01355 ^@ http://purl.uniprot.org/uniprot/I3R6A1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Cell membrane|||Involved in protein export.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the protein translocation apparatus. Forms a complex with SecF. http://togogenome.org/gene/523841:E6P09_RS11185 ^@ http://purl.uniprot.org/uniprot/I3R525 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6B family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/523841:E6P09_RS03835 ^@ http://purl.uniprot.org/uniprot/I3R0X8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS08555 ^@ http://purl.uniprot.org/uniprot/I3R3L2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.|||Homodimer.|||Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. http://togogenome.org/gene/523841:E6P09_RS08035 ^@ http://purl.uniprot.org/uniprot/I3R3A7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS12835 ^@ http://purl.uniprot.org/uniprot/I3R8A4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/523841:E6P09_RS12380 ^@ http://purl.uniprot.org/uniprot/I3R8J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS01785 ^@ http://purl.uniprot.org/uniprot/I3R614 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523841:E6P09_RS09380 ^@ http://purl.uniprot.org/uniprot/I3R428 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/523841:E6P09_RS01740 ^@ http://purl.uniprot.org/uniprot/I3R623 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.|||Nucleus|||Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure. http://togogenome.org/gene/523841:E6P09_RS00020 ^@ http://purl.uniprot.org/uniprot/I3R707 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal DnaG primase family.|||Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. http://togogenome.org/gene/523841:E6P09_RS09900 ^@ http://purl.uniprot.org/uniprot/I3R4C5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/523841:E6P09_RS13745 ^@ http://purl.uniprot.org/uniprot/I3R7S5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the quinolinate synthase family. Type 3 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS14200 ^@ http://purl.uniprot.org/uniprot/I3R7I2 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/523841:E6P09_RS05055 ^@ http://purl.uniprot.org/uniprot/I3R1M3 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/523841:E6P09_RS04990 ^@ http://purl.uniprot.org/uniprot/I3R1L0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M32 family.|||Binds 1 zinc ion per subunit.|||Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. http://togogenome.org/gene/523841:E6P09_RS06340 ^@ http://purl.uniprot.org/uniprot/I3R2C3 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/523841:E6P09_RS11180 ^@ http://purl.uniprot.org/uniprot/I3R524 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6A family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/523841:E6P09_RS10480 ^@ http://purl.uniprot.org/uniprot/I3R4N9 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/523841:E6P09_RS08300 ^@ http://purl.uniprot.org/uniprot/I3R3F9 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/523841:E6P09_RS18700 ^@ http://purl.uniprot.org/uniprot/I3R9K1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dethiobiotin synthetase family.|||Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring (By similarity). This archaea does not encode bioA (which catalyzes the formation of the precursor for this reaction in the cannonical pathway), instead it encodes bioU, which replaces bioA and also performs the first half of the cannonical BioD reaction. Thus in this archaea BioD has a different substrate (By similarity).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS03110 ^@ http://purl.uniprot.org/uniprot/I3R0I8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA polymerase delta/II small subunit family.|||Heterodimer of a large subunit and a small subunit.|||Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. http://togogenome.org/gene/523841:E6P09_RS08295 ^@ http://purl.uniprot.org/uniprot/I3R3F8 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/523841:E6P09_RS05475 ^@ http://purl.uniprot.org/uniprot/I3R1V6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal dihydroneopterin aldolase family.|||Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).|||Homotetramer. http://togogenome.org/gene/523841:E6P09_RS12100 ^@ http://purl.uniprot.org/uniprot/I3R5K8 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/523841:E6P09_RS18060 ^@ http://purl.uniprot.org/uniprot/I3RA10 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DtxR/MntR family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS13000 ^@ http://purl.uniprot.org/uniprot/I3R872 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/523841:E6P09_RS14465 ^@ http://purl.uniprot.org/uniprot/I3R7D9 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/523841:E6P09_RS02000 ^@ http://purl.uniprot.org/uniprot/I3R5X6 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/523841:E6P09_RS03345 ^@ http://purl.uniprot.org/uniprot/I3R0N3 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS11275 ^@ http://purl.uniprot.org/uniprot/M0J662|||http://purl.uniprot.org/uniprot/Q9HHB8 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/523841:E6P09_RS10820 ^@ http://purl.uniprot.org/uniprot/I3R4V4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS06335 ^@ http://purl.uniprot.org/uniprot/I3R2C2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-alpha family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/523841:E6P09_RS16350 ^@ http://purl.uniprot.org/uniprot/A0A4P8P6Z4|||http://purl.uniprot.org/uniprot/I3RB26 ^@ Disruption Phenotype|||Function|||Miscellaneous|||Similarity ^@ Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). This protein probably processes pre-crRNA into individual crRNA units, and also plays a role in generation or stability of the CRISPR leader-repeat transcript. Cleaves an endogenous (non-invading) RNA; cuts a specific site within a sequence nearly identical to the cognate CRISPR repeat sequence in the 5' UTR of the transcript of provirus gene phiH, found in provirus 1. This digestion might be responsible for inhibiting (defective) provirus 1 excision.|||Does not produce mature length crRNA; precursor is non-specifically degraded. No accumulation of the CRISPR leader-repeat transcript. Allows excision of defective provirus 1 from its chromosomal locus (detected as restoration of the attachment site attA).|||There are 6 CRISPR RNA loci in this organism and a single cas gene locus. A CRISPR-Cas type I-B system. http://togogenome.org/gene/523841:E6P09_RS03945 ^@ http://purl.uniprot.org/uniprot/I3R100 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. http://togogenome.org/gene/523841:E6P09_RS04145 ^@ http://purl.uniprot.org/uniprot/I3R138 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS09185 ^@ http://purl.uniprot.org/uniprot/I3R3Y8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS03155 ^@ http://purl.uniprot.org/uniprot/I3R0J6 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/523841:E6P09_RS17625 ^@ http://purl.uniprot.org/uniprot/I3R9R9 ^@ Similarity ^@ Belongs to the NAPRTase family. http://togogenome.org/gene/523841:E6P09_RS06405 ^@ http://purl.uniprot.org/uniprot/I3R2D5 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the shikimate dehydrogenase family.|||Homodimer.|||Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS00905 ^@ http://purl.uniprot.org/uniprot/I3R6I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523841:E6P09_RS14585 ^@ http://purl.uniprot.org/uniprot/I3R7B7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS13110 ^@ http://purl.uniprot.org/uniprot/I3R849 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/523841:E6P09_RS15160 ^@ http://purl.uniprot.org/uniprot/I3RAE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523841:E6P09_RS04075 ^@ http://purl.uniprot.org/uniprot/I3R124 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/523841:E6P09_RS08790 ^@ http://purl.uniprot.org/uniprot/I3R3R1 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/523841:E6P09_RS11875 ^@ http://purl.uniprot.org/uniprot/I3R5G3 ^@ Function|||Similarity ^@ Belongs to the TFIIB family.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/523841:E6P09_RS04230 ^@ http://purl.uniprot.org/uniprot/I3R155 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/523841:E6P09_RS03545 ^@ http://purl.uniprot.org/uniprot/I3R0S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS07100 ^@ http://purl.uniprot.org/uniprot/I3R2S6 ^@ Cofactor ^@ The crystal structure with reduced Cu(1+) has also been determined. http://togogenome.org/gene/523841:E6P09_RS04690 ^@ http://purl.uniprot.org/uniprot/I3R1E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS05225 ^@ http://purl.uniprot.org/uniprot/I3R1Q7 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/523841:E6P09_RS10690 ^@ http://purl.uniprot.org/uniprot/M0J670 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS00875 ^@ http://purl.uniprot.org/uniprot/I3R6J1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS07900 ^@ http://purl.uniprot.org/uniprot/I3R379 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/523841:E6P09_RS15930 ^@ http://purl.uniprot.org/uniprot/I3RBB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/523841:E6P09_RS01550 ^@ http://purl.uniprot.org/uniprot/I3R661 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the CofE family.|||Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.|||Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.|||Homodimer.|||Monovalent cation. The ion could be potassium. http://togogenome.org/gene/523841:E6P09_RS00200 ^@ http://purl.uniprot.org/uniprot/I3R6X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS01745 ^@ http://purl.uniprot.org/uniprot/I3R622 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Spt4 family.|||Heterodimer composed of Spt4 and Spt5.|||Stimulates transcription elongation. http://togogenome.org/gene/523841:E6P09_RS04785 ^@ http://purl.uniprot.org/uniprot/I3R1G8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/523841:E6P09_RS16690 ^@ http://purl.uniprot.org/uniprot/I3RAV1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/523841:E6P09_RS12320 ^@ http://purl.uniprot.org/uniprot/I3R8K3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS15935 ^@ http://purl.uniprot.org/uniprot/I3RBB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS12360 ^@ http://purl.uniprot.org/uniprot/I3R8J5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidine kinase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/523841:E6P09_RS14130 ^@ http://purl.uniprot.org/uniprot/I3R7J7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS04575 ^@ http://purl.uniprot.org/uniprot/I3R1C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS17730 ^@ http://purl.uniprot.org/uniprot/M0J8A7 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/523841:E6P09_RS18940 ^@ http://purl.uniprot.org/uniprot/I3R903 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/523841:E6P09_RS03405 ^@ http://purl.uniprot.org/uniprot/I3R0P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS14330 ^@ http://purl.uniprot.org/uniprot/I3R7G3 ^@ Cofactor|||Domain|||Function|||Subunit ^@ Binds 2 magnesium or manganese ions per subunit.|||Consists of an N-terminal biotin carboxylation/carboxylase (BC) domain that catalyzes the transient carboxylation of the biotin covalently attached to the C-terminal biotinyl-binding/biotin carboxyl carrier (BCC) domain.|||The propionyl coenzyme A carboxylase (PCC) complex is composed of three subunits: PccA (biotin carboxylase and biotin-carboxyl carrier), PccB (carboxyltransferase) and PccX.|||This is one of the subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), the enzyme catalyzing the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA. Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase is involved in propionate utilization and in the production of the poly(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV), which is a water-insoluble biopolymer used as intracellular energy reserve material when cells grow under conditions of nutrient limitation (PubMed:25398867). Propionyl-CoA carboxylase is also able to catalyze the carboxylation of acetyl-CoA (PubMed:25398867). http://togogenome.org/gene/523841:E6P09_RS15475 ^@ http://purl.uniprot.org/uniprot/I3RA81 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase class-2 family.|||Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. http://togogenome.org/gene/523841:E6P09_RS18525 ^@ http://purl.uniprot.org/uniprot/M0JBD1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. http://togogenome.org/gene/523841:E6P09_RS02795 ^@ http://purl.uniprot.org/uniprot/I3R8S6 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. http://togogenome.org/gene/523841:E6P09_RS13800 ^@ http://purl.uniprot.org/uniprot/I3R7R4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS03305 ^@ http://purl.uniprot.org/uniprot/I3R0M6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family. LysK subfamily.|||Binds 2 Zn(2+) or Co(2+) ions per subunit.|||Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS11740 ^@ http://purl.uniprot.org/uniprot/I3R5D7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS07940 ^@ http://purl.uniprot.org/uniprot/I3R387 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS10485 ^@ http://purl.uniprot.org/uniprot/I3R4P0 ^@ Function ^@ Protects DNA against thermal denaturation and modulates transcription. http://togogenome.org/gene/523841:E6P09_RS07960 ^@ http://purl.uniprot.org/uniprot/I3R391 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS03990 ^@ http://purl.uniprot.org/uniprot/I3R109 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.|||Cytoplasm|||Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. http://togogenome.org/gene/523841:E6P09_RS08675 ^@ http://purl.uniprot.org/uniprot/I3R3N7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/523841:E6P09_RS07905 ^@ http://purl.uniprot.org/uniprot/I3R380 ^@ Caution|||Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS07890 ^@ http://purl.uniprot.org/uniprot/I3R377 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. Hel308 subfamily.|||DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.|||Monomer. http://togogenome.org/gene/523841:E6P09_RS01545 ^@ http://purl.uniprot.org/uniprot/I3R662 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mer family.|||Catalyzes the oxidation of methyl-H(4)MPT to methylene-H(4)MPT.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS13870 ^@ http://purl.uniprot.org/uniprot/I3R7Q3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/523841:E6P09_RS08320 ^@ http://purl.uniprot.org/uniprot/I3R3G3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS01730 ^@ http://purl.uniprot.org/uniprot/I3R625 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/523841:E6P09_RS12960 ^@ http://purl.uniprot.org/uniprot/I3R880 ^@ Function|||Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family.|||Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. http://togogenome.org/gene/523841:E6P09_RS00405 ^@ http://purl.uniprot.org/uniprot/I3R6T6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. CofG family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.|||The FO synthase complex consists of two subunits, CofG and CofH. http://togogenome.org/gene/523841:E6P09_RS00120 ^@ http://purl.uniprot.org/uniprot/I3R6Y7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Cytoplasm|||Functions by promoting the formation of the first peptide bond. http://togogenome.org/gene/523841:E6P09_RS06190 ^@ http://purl.uniprot.org/uniprot/I3R293 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTH2 family.|||Cytoplasm|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/523841:E6P09_RS14570 ^@ http://purl.uniprot.org/uniprot/A0A059TXL0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS14785 ^@ http://purl.uniprot.org/uniprot/I3R776 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS00030 ^@ http://purl.uniprot.org/uniprot/I3R705 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS05890 ^@ http://purl.uniprot.org/uniprot/I3R233 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/523841:E6P09_RS11030 ^@ http://purl.uniprot.org/uniprot/I3R4Z5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.|||Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.|||Membrane http://togogenome.org/gene/523841:E6P09_RS01060 ^@ http://purl.uniprot.org/uniprot/I3R6F7 ^@ Similarity ^@ Belongs to the GbsR family. http://togogenome.org/gene/523841:E6P09_RS05305 ^@ http://purl.uniprot.org/uniprot/I3R1S2 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/523841:E6P09_RS10885 ^@ http://purl.uniprot.org/uniprot/M0J973 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS08100 ^@ http://purl.uniprot.org/uniprot/I3R3C1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the archaeal FAD synthase family.|||Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS06475 ^@ http://purl.uniprot.org/uniprot/I3R2E9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS10340 ^@ http://purl.uniprot.org/uniprot/I3R4L1 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/523841:E6P09_RS03350 ^@ http://purl.uniprot.org/uniprot/I3R0N4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS01790 ^@ http://purl.uniprot.org/uniprot/I3R613 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS12910 ^@ http://purl.uniprot.org/uniprot/I3R890 ^@ Function|||Similarity|||Subunit ^@ Belongs to the isopentenyl phosphate kinase family.|||Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS08250 ^@ http://purl.uniprot.org/uniprot/I3R3E8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/523841:E6P09_RS01565 ^@ http://purl.uniprot.org/uniprot/I3R658 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/523841:E6P09_RS13655 ^@ http://purl.uniprot.org/uniprot/I3R7U2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.|||Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS16280 ^@ http://purl.uniprot.org/uniprot/I3RB41 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/523841:E6P09_RS13075 ^@ http://purl.uniprot.org/uniprot/I3R856 ^@ Cofactor|||Function ^@ Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Binds 1 zinc ion.|||Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/523841:E6P09_RS13035 ^@ http://purl.uniprot.org/uniprot/I3R865 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Cytoplasm|||Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.|||Part of the 50S ribosomal subunit. Probably part of the RNase P complex. http://togogenome.org/gene/523841:E6P09_RS07140 ^@ http://purl.uniprot.org/uniprot/I3R2T4 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the SMC family. RAD50 subfamily.|||Binds 1 zinc ion per homodimer.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.|||The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer. http://togogenome.org/gene/523841:E6P09_RS08525 ^@ http://purl.uniprot.org/uniprot/I3R3K6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/523841:E6P09_RS11505 ^@ http://purl.uniprot.org/uniprot/Q02229 ^@ Disruption Phenotype|||Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gas vesicle GvpD family.|||Causes a decrease in the amount of GvpE protein; tested in transgenic H.volcanii (PubMed:12864859, PubMed:17379705, PubMed:23589224) (Probable). Plays a role in repression of excess gas vesicle formation (PubMed:1282192, PubMed:8757736, PubMed:11160801, PubMed:12864859). In transformed H.volcanii, an internal deletion in this protein leads to very high gas vesicle production and overproduction of gvpA mRNA; complementation with wild-type GvpD under its own promoter yields normal gas vesicle production and gvpA transcripts. Overexpression under a strong promoter prevents gas vesicle formation and causes large decreases in gvpA transcripts (PubMed:11160801, PubMed:8757736). Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat (By similarity).|||Cytoplasm|||Encoded in a 14-gene locus called mc-vac.|||Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.|||Highly up-regulated gas vesicle formation in H.volcanii; cells are tightly filled with gas vesicles, are nearly round and lyse easily. In transformed H.volcanii, gvpA is translated at high levels in both log and stationary phase. This is not a true deletion mutant but rather an in-frame removal of residues 117-423, so a shorter protein is probably translated (PubMed:1282192). The same deletion constitutively transcribes from both promoters, leading to greatly increased transcripts of both loci in exponential and stationary phases (PubMed:8757736).|||In Schmidt et al., GvpD comes from H.mediterranei while GvpE is from the c-locus of H.salinarum.|||Interacts with GvpE, also with c-GvpE from H.salinarum.|||Transcribed from mid-log to stationary phase, probably as a gvpD-gvpE RNA (PubMed:1404376). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736). Accumulates in stationary phase (at protein level) (PubMed:12864859). http://togogenome.org/gene/523841:E6P09_RS18960 ^@ http://purl.uniprot.org/uniprot/I3R907 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/523841:E6P09_RS14215 ^@ http://purl.uniprot.org/uniprot/I3R7H9 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.|||Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/523841:E6P09_RS13845 ^@ http://purl.uniprot.org/uniprot/I3R7Q8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/523841:E6P09_RS11550 ^@ http://purl.uniprot.org/uniprot/M0J8R7|||http://purl.uniprot.org/uniprot/Q02238 ^@ Disruption Phenotype|||Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gas vesicle GvpA family.|||Encoded in a 14-gene locus called mc-vac.|||Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.|||Gas vesicle|||GvpF to GvpM interact with each other in vitro, and may form multi-subunit complex(es). Might interact with GvpA.|||No longer makes gas vesicles in H.volcanii; cells translate GvpA but do not make gas vesicles.|||Proteins GvpF to GvpM might be involved in nucleating gas vesicle formation. A minor component of the gas vesicle (By similarity). Gas vesicles are small, hollow, gas filled protein structures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat (By similarity).|||Transcribed from early-log phase, decreases as cells enter stationary phase, probably as a long gvpF-gvpM RNA (PubMed:1404376). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736). http://togogenome.org/gene/523841:E6P09_RS18350 ^@ http://purl.uniprot.org/uniprot/I3R9C8 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/523841:E6P09_RS09835 ^@ http://purl.uniprot.org/uniprot/I3R4B3 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/523841:E6P09_RS14170 ^@ http://purl.uniprot.org/uniprot/I3R7I9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/523841:E6P09_RS01995 ^@ http://purl.uniprot.org/uniprot/I3R5X7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS19 family.|||May be involved in maturation of the 30S ribosomal subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/523841:E6P09_RS05115 ^@ http://purl.uniprot.org/uniprot/I3R1N5 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family. http://togogenome.org/gene/523841:E6P09_RS17870 ^@ http://purl.uniprot.org/uniprot/I3R9W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS06780 ^@ http://purl.uniprot.org/uniprot/I3R2L3 ^@ Function ^@ Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. http://togogenome.org/gene/523841:E6P09_RS10675 ^@ http://purl.uniprot.org/uniprot/I3R4S5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/523841:E6P09_RS05290 ^@ http://purl.uniprot.org/uniprot/I3R1R9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/523841:E6P09_RS08905 ^@ http://purl.uniprot.org/uniprot/I3R3T0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS11230 ^@ http://purl.uniprot.org/uniprot/I3R534 ^@ Similarity ^@ Belongs to the PNP/UDP phosphorylase family. http://togogenome.org/gene/523841:E6P09_RS06120 ^@ http://purl.uniprot.org/uniprot/I3R281 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. http://togogenome.org/gene/523841:E6P09_RS18755 ^@ http://purl.uniprot.org/uniprot/I3R9L2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS15170 ^@ http://purl.uniprot.org/uniprot/I3RAE3 ^@ Caution|||Similarity ^@ Belongs to the peptidase S8 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS06730 ^@ http://purl.uniprot.org/uniprot/I3R2K3 ^@ Similarity ^@ Belongs to the SAM hydrolase / SAM-dependent halogenase family. http://togogenome.org/gene/523841:E6P09_RS06265 ^@ http://purl.uniprot.org/uniprot/I3R2A8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/523841:E6P09_RS10115 ^@ http://purl.uniprot.org/uniprot/I3R4G8 ^@ Similarity|||Subunit ^@ Belongs to the HTP reductase family.|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS06505 ^@ http://purl.uniprot.org/uniprot/I3R2F5 ^@ Caution|||Function|||Similarity ^@ Belongs to the Nre family.|||Involved in DNA damage repair.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS00125 ^@ http://purl.uniprot.org/uniprot/I3R6Y6 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/523841:E6P09_RS18555 ^@ http://purl.uniprot.org/uniprot/I3R9H2 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/523841:E6P09_RS01875 ^@ http://purl.uniprot.org/uniprot/I3R5Z8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS03320 ^@ http://purl.uniprot.org/uniprot/I3R0M9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.|||Cytoplasm|||Involved in both the arginine and lysine biosynthetic pathways.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS14575 ^@ http://purl.uniprot.org/uniprot/I3R7B9 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.|||In the N-terminal section; belongs to the malic enzymes family. http://togogenome.org/gene/523841:E6P09_RS17610 ^@ http://purl.uniprot.org/uniprot/I3R9R6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAL/histidase family.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS00800 ^@ http://purl.uniprot.org/uniprot/I3R6K7 ^@ Similarity|||Subunit ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Homohexamer. http://togogenome.org/gene/523841:E6P09_RS12730 ^@ http://purl.uniprot.org/uniprot/I3R8C1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uridine kinase family.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS08800 ^@ http://purl.uniprot.org/uniprot/I3R3R3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS1 family. http://togogenome.org/gene/523841:E6P09_RS05200 ^@ http://purl.uniprot.org/uniprot/I3R1Q1 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/523841:E6P09_RS13020 ^@ http://purl.uniprot.org/uniprot/I3R868 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||Cytoplasm|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/523841:E6P09_RS16925 ^@ http://purl.uniprot.org/uniprot/I3RAP8 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/523841:E6P09_RS15815 ^@ http://purl.uniprot.org/uniprot/I3RBE1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic CoaD family.|||Cytoplasm|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/523841:E6P09_RS01870 ^@ http://purl.uniprot.org/uniprot/I3R5Z9 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/523841:E6P09_RS12710 ^@ http://purl.uniprot.org/uniprot/I3R8C5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS11020 ^@ http://purl.uniprot.org/uniprot/I3R4Z3 ^@ Function|||Similarity ^@ Belongs to the archaeal SPP-like hydrolase family.|||Catalyzes the dephosphorylation of 2-phosphoglycolate. http://togogenome.org/gene/523841:E6P09_RS09045 ^@ http://purl.uniprot.org/uniprot/I3R3V9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS04395 ^@ http://purl.uniprot.org/uniprot/I3R191 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the spermidine/spermine synthase family.|||Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.|||Cell membrane|||Homodimer or homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS00570 ^@ http://purl.uniprot.org/uniprot/I3R6Q3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS10665 ^@ http://purl.uniprot.org/uniprot/I3R4S3 ^@ Function|||Similarity ^@ Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.|||Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB). http://togogenome.org/gene/523841:E6P09_RS03665 ^@ http://purl.uniprot.org/uniprot/I3R0U8 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family.|||Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. http://togogenome.org/gene/523841:E6P09_RS02660 ^@ http://purl.uniprot.org/uniprot/I3R8Q0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.|||Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.|||Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS07455 ^@ http://purl.uniprot.org/uniprot/I3R2Z8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the diphthine synthase family.|||Homodimer.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/523841:E6P09_RS18330 ^@ http://purl.uniprot.org/uniprot/I3RA65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS03230 ^@ http://purl.uniprot.org/uniprot/I3R0L1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/523841:E6P09_RS14485 ^@ http://purl.uniprot.org/uniprot/I3R7D5 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase class-2 family.|||Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. http://togogenome.org/gene/523841:E6P09_RS09060 ^@ http://purl.uniprot.org/uniprot/I3R3W2 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/523841:E6P09_RS11290 ^@ http://purl.uniprot.org/uniprot/M0J5P1|||http://purl.uniprot.org/uniprot/Q9HHC2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/523841:E6P09_RS10420 ^@ http://purl.uniprot.org/uniprot/I3R4M7 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/523841:E6P09_RS04535 ^@ http://purl.uniprot.org/uniprot/I3R1B8 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/523841:E6P09_RS10160 ^@ http://purl.uniprot.org/uniprot/I3R4H6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/523841:E6P09_RS02305 ^@ http://purl.uniprot.org/uniprot/I3R5R3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 6-phosphogluconate dehydrogenase family.|||Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH.|||Homotetramer. http://togogenome.org/gene/523841:E6P09_RS05135 ^@ http://purl.uniprot.org/uniprot/I3R1N9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/523841:E6P09_RS06330 ^@ http://purl.uniprot.org/uniprot/I3R2C1 ^@ Function|||Similarity ^@ Belongs to the NOP10 family.|||Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. http://togogenome.org/gene/523841:E6P09_RS11165 ^@ http://purl.uniprot.org/uniprot/I3R521 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent DNA ligase family.|||DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. http://togogenome.org/gene/523841:E6P09_RS09355 ^@ http://purl.uniprot.org/uniprot/I3R423 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS15610 ^@ http://purl.uniprot.org/uniprot/I3RBI2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS08415 ^@ http://purl.uniprot.org/uniprot/I3R3I3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS08815 ^@ http://purl.uniprot.org/uniprot/I3R3R6 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/523841:E6P09_RS17995 ^@ http://purl.uniprot.org/uniprot/I3R9Z4 ^@ Biotechnology|||Disruption Phenotype|||Function|||Similarity|||Subunit ^@ Belongs to the PHA/PHB synthase family.|||Depletion of both phaC and phaE genes leads to complete loss of PHA synthase activity and PHBV production.|||Heterodimer with PhaE.|||Involved in the production of polyhydroxyalkonic acids (PHAs), which are water-insoluble biopolymers used as intracellular energy reserve material when cells grow under conditions of nutrient limitation. PHAs are composed primarily of 3-hydroxybutyric acid (3HB) and 3-hydroxyvaleric acid (3HV). Required for the production of poly-beta-hydroxybutyrate (PHB) and poly(beta-hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV).|||PHB and PHBV are desirable bioplastic due to their biodegradability, biocompatibility, and mechanical properties. However, PHBV has better mechanical properties than PHB. http://togogenome.org/gene/523841:E6P09_RS01035 ^@ http://purl.uniprot.org/uniprot/I3R6G2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||S-layer http://togogenome.org/gene/523841:E6P09_RS11300 ^@ http://purl.uniprot.org/uniprot/I3R549 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/523841:E6P09_RS01750 ^@ http://purl.uniprot.org/uniprot/I3R621 ^@ Function|||Similarity ^@ Belongs to the GTP-dependent DPCK family.|||Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). http://togogenome.org/gene/523841:E6P09_RS13575 ^@ http://purl.uniprot.org/uniprot/I3R7V8 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/523841:E6P09_RS10835 ^@ http://purl.uniprot.org/uniprot/I3R4V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PEP-utilizing enzyme family.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS06470 ^@ http://purl.uniprot.org/uniprot/I3R2E8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endonuclease V family.|||Cytoplasm|||DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. http://togogenome.org/gene/523841:E6P09_RS16680 ^@ http://purl.uniprot.org/uniprot/I3RAV4 ^@ Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. http://togogenome.org/gene/523841:E6P09_RS11525 ^@ http://purl.uniprot.org/uniprot/Q02233 ^@ Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gas vesicle GvpH family.|||Encoded in a 14-gene locus called mc-vac.|||Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.|||Gas vesicle|||GvpF to GvpM interact with each other in vitro, and may form multi-subunit complex(es). Interacts with GvpC. Might interact with GvpA.|||Proteins GvpF to GvpM might be involved in nucleating gas vesicle formation (By similarity). A minor component of the gas vesicle (By similarity). Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat (By similarity).|||Transcribed from early-log phase, decreases as cells enter stationary phase, probably as a long gvpF-gvpM RNA (PubMed:1404376). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736). http://togogenome.org/gene/523841:E6P09_RS01215 ^@ http://purl.uniprot.org/uniprot/I3R6C6 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/523841:E6P09_RS01960 ^@ http://purl.uniprot.org/uniprot/I3R5Y3 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS01390 ^@ http://purl.uniprot.org/uniprot/I3R694 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS04710 ^@ http://purl.uniprot.org/uniprot/I3R1F3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.|||Belongs to the TiaS family.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS10540 ^@ http://purl.uniprot.org/uniprot/I3R4P8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.|||Cell membrane|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/523841:E6P09_RS17725 ^@ http://purl.uniprot.org/uniprot/I3R9U2 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/523841:E6P09_RS15165 ^@ http://purl.uniprot.org/uniprot/I3RAE4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS17170 ^@ http://purl.uniprot.org/uniprot/I3RAJ9 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/523841:E6P09_RS05710 ^@ http://purl.uniprot.org/uniprot/I3R1Z8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/523841:E6P09_RS12705 ^@ http://purl.uniprot.org/uniprot/I3R8C6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS18240 ^@ http://purl.uniprot.org/uniprot/A0A059TWJ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS12195 ^@ http://purl.uniprot.org/uniprot/I3R8M7 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/523841:E6P09_RS04290 ^@ http://purl.uniprot.org/uniprot/I3R168 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS06430 ^@ http://purl.uniprot.org/uniprot/M0J3L0|||http://purl.uniprot.org/uniprot/Q9V2S5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.|||Membrane http://togogenome.org/gene/523841:E6P09_RS01990 ^@ http://purl.uniprot.org/uniprot/I3R5X8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS02040 ^@ http://purl.uniprot.org/uniprot/M0IT87 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Golgi apparatus|||Lysosome http://togogenome.org/gene/523841:E6P09_RS08795 ^@ http://purl.uniprot.org/uniprot/I3R3R2 ^@ Cofactor ^@ Binds 1 copper ion per subunit. http://togogenome.org/gene/523841:E6P09_RS13765 ^@ http://purl.uniprot.org/uniprot/I3R7S1 ^@ Similarity ^@ Belongs to the OMP decarboxylase family. Type 2 subfamily. http://togogenome.org/gene/523841:E6P09_RS11135 ^@ http://purl.uniprot.org/uniprot/M0J9V3 ^@ Caution|||Similarity ^@ Belongs to the cytochrome P450 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. http://togogenome.org/gene/523841:E6P09_RS16390 ^@ http://purl.uniprot.org/uniprot/I3RB17 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS15670 ^@ http://purl.uniprot.org/uniprot/I3RBH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS11800 ^@ http://purl.uniprot.org/uniprot/I3R5F0 ^@ Function|||Similarity ^@ Belongs to the adenylate cyclase family. DacZ subfamily.|||Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. http://togogenome.org/gene/523841:E6P09_RS04780 ^@ http://purl.uniprot.org/uniprot/I3R1G7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Part of the 30S ribosomal subunit.|||With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. http://togogenome.org/gene/523841:E6P09_RS05920 ^@ http://purl.uniprot.org/uniprot/I3R240 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Cell membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.|||Membrane http://togogenome.org/gene/523841:E6P09_RS18710 ^@ http://purl.uniprot.org/uniprot/I3R9K3 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A 'suicide' enzyme that participates in biotin synthesis. Catalyzes the formation of (S)-8-amino-7-oxononanoate (DAN-carbamic acid) from (7R,8S)-8-amino-7-(carboxyamino)nonanoate (DAN), a function equivalent to the cannonical BioA reaction and the first half-reaction of BioD. The cellular requirement for biotin is thought be low enough that this single turnover enzyme supplies a sufficient amount of the cofactor. Overall it catalyzes three reactions: formation of a covalent linkage with 8-amino-7-oxononanoate to yield a BioU-DAN conjugate at the epsilon-amino group of Lys124 of BioU using NAD(P)H, carboxylation of the conjugate to form BioU-DAN-carbamic acid, and release of DAN-carbamic acid using NAD(P)+ (By similarity). Complements a bioA deletion in E.coli (PubMed:32042199).|||Belongs to the BioU family.|||In cannonical biotin synthesis a pimeloyl-conjugate is transformed into biotin by the subsequent action of BioF, BioA, BioD and BioB. This enzyme replaces BioA and performs the first half-reaction of BioD.|||Monomer. http://togogenome.org/gene/523841:E6P09_RS12120 ^@ http://purl.uniprot.org/uniprot/I3R5L2 ^@ Caution|||Function|||Similarity ^@ Belongs to the TBP family.|||General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS04660 ^@ http://purl.uniprot.org/uniprot/I3R1E3 ^@ Function|||Similarity ^@ Acts on leucine, isoleucine and valine.|||Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/523841:E6P09_RS14950 ^@ http://purl.uniprot.org/uniprot/I3R743 ^@ Similarity ^@ Belongs to the peptidase S66 family. http://togogenome.org/gene/523841:E6P09_RS12845 ^@ http://purl.uniprot.org/uniprot/I3R8A2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/523841:E6P09_RS03160 ^@ http://purl.uniprot.org/uniprot/I3R0J7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. Hel308 subfamily.|||DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.|||Monomer. http://togogenome.org/gene/523841:E6P09_RS13140 ^@ http://purl.uniprot.org/uniprot/I3R844 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/523841:E6P09_RS16270 ^@ http://purl.uniprot.org/uniprot/I3RB43 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PAL/histidase family.|||Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS05765 ^@ http://purl.uniprot.org/uniprot/I3R209 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GGGP/HepGP synthase family. Group I subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/523841:E6P09_RS01685 ^@ http://purl.uniprot.org/uniprot/I3R634 ^@ Activity Regulation|||Cofactor|||Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.|||Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.|||Cytoplasm|||Enzyme stability and activity depend upon the salt concentration.|||Inhibited by cyanide and azide.|||Is probably a monomer (PubMed:16182473). Initially characterized as a dimer of proteins with a MW of 105 and 50 kDa (PubMed:11731152).|||Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation. Catalyzes the reduction of nitrate to nitrite, using ferredoxin as the electron donor. Can use reduced methyl viologen but neither NADPH nor NADH as electron donors.|||Repressed by the presence of ammonium as nitrogen source. http://togogenome.org/gene/523841:E6P09_RS00355 ^@ http://purl.uniprot.org/uniprot/I3R6U6 ^@ Function ^@ Part of a potassium transport system. http://togogenome.org/gene/523841:E6P09_RS06160 ^@ http://purl.uniprot.org/uniprot/I3R288 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/523841:E6P09_RS06645 ^@ http://purl.uniprot.org/uniprot/I3R2I4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS08765 ^@ http://purl.uniprot.org/uniprot/I3R3Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS06085 ^@ http://purl.uniprot.org/uniprot/I3R274 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/523841:E6P09_RS11540 ^@ http://purl.uniprot.org/uniprot/M0J604|||http://purl.uniprot.org/uniprot/Q02236 ^@ Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gas vesicle GvpK family.|||Encoded in a 14-gene locus called mc-vac.|||Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.|||Gas vesicle|||GvpF to GvpM interact with each other in vitro, and may form multi-subunit complex(es).|||Proteins GvpF to GvpM might be involved in nucleating gas vesicle formation (By similarity). Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat (By similarity).|||Transcribed from early-log phase, decreases as cells enter stationary phase, probably as a long gvpF-gvpM RNA (PubMed:1404376). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736).|||Vesicle http://togogenome.org/gene/523841:E6P09_RS07765 ^@ http://purl.uniprot.org/uniprot/I3R353 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS00580 ^@ http://purl.uniprot.org/uniprot/I3R6Q1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS16330 ^@ http://purl.uniprot.org/uniprot/I3RB30 ^@ Similarity ^@ In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.|||In the central section; belongs to the CRISPR-associated helicase Cas3 family. http://togogenome.org/gene/523841:E6P09_RS07935 ^@ http://purl.uniprot.org/uniprot/I3R386 ^@ Similarity ^@ In the C-terminal section; belongs to the complex I 49 kDa subunit family. http://togogenome.org/gene/523841:E6P09_RS10850 ^@ http://purl.uniprot.org/uniprot/I3R4W0 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS13205 ^@ http://purl.uniprot.org/uniprot/I3R834 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/523841:E6P09_RS06990 ^@ http://purl.uniprot.org/uniprot/I3R2Q5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycerol-1-phosphate dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS05750 ^@ http://purl.uniprot.org/uniprot/I3R206 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS05895 ^@ http://purl.uniprot.org/uniprot/I3R234 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS03370 ^@ http://purl.uniprot.org/uniprot/I3R0N8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS13465 ^@ http://purl.uniprot.org/uniprot/I3R7X8 ^@ Similarity ^@ Belongs to the mandelate racemase/muconate lactonizing enzyme family. http://togogenome.org/gene/523841:E6P09_RS11775 ^@ http://purl.uniprot.org/uniprot/I3R5E5 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/523841:E6P09_RS16485 ^@ http://purl.uniprot.org/uniprot/I3RAZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS01560 ^@ http://purl.uniprot.org/uniprot/I3R659 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/523841:E6P09_RS08420 ^@ http://purl.uniprot.org/uniprot/I3R3I4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS01445 ^@ http://purl.uniprot.org/uniprot/I3R683 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.|||Belongs to the AAA ATPase family.|||Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.|||Cytoplasm|||Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets. http://togogenome.org/gene/523841:E6P09_RS16490 ^@ http://purl.uniprot.org/uniprot/I3RAZ7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS03190 ^@ http://purl.uniprot.org/uniprot/I3R0K3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS15265 ^@ http://purl.uniprot.org/uniprot/I3RAC3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0182 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS04175 ^@ http://purl.uniprot.org/uniprot/I3R144 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||S-layer http://togogenome.org/gene/523841:E6P09_RS04355 ^@ http://purl.uniprot.org/uniprot/I3R182 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/523841:E6P09_RS10895 ^@ http://purl.uniprot.org/uniprot/I3R4W9 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/523841:E6P09_RS14110 ^@ http://purl.uniprot.org/uniprot/I3R7K1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family.|||Binds 2 manganese ions per subunit.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/523841:E6P09_RS07250 ^@ http://purl.uniprot.org/uniprot/I3R2V6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS15915 ^@ http://purl.uniprot.org/uniprot/I3RBB8 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/523841:E6P09_RS01665 ^@ http://purl.uniprot.org/uniprot/I3R638 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/523841:E6P09_RS16900 ^@ http://purl.uniprot.org/uniprot/I3RAQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523841:E6P09_RS00195 ^@ http://purl.uniprot.org/uniprot/I3R6X3 ^@ Function|||Similarity ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.|||May catalyze a purine salvage reaction, the substrate is unknown. http://togogenome.org/gene/523841:E6P09_RS18200 ^@ http://purl.uniprot.org/uniprot/M0JAL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS11045 ^@ http://purl.uniprot.org/uniprot/I3R4Z8 ^@ Caution|||Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS06660 ^@ http://purl.uniprot.org/uniprot/I3R2I7 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/523841:E6P09_RS13550 ^@ http://purl.uniprot.org/uniprot/I3R7W3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta-RFA-P synthase family.|||Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS12315 ^@ http://purl.uniprot.org/uniprot/I3R8K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523841:E6P09_RS06345 ^@ http://purl.uniprot.org/uniprot/I3R2C4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/523841:E6P09_RS05915 ^@ http://purl.uniprot.org/uniprot/I3R238 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobD/CbiB family.|||Cell membrane|||Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/523841:E6P09_RS13025 ^@ http://purl.uniprot.org/uniprot/I3R867 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL24 family.|||Binds to the 23S rRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14. http://togogenome.org/gene/523841:E6P09_RS14865 ^@ http://purl.uniprot.org/uniprot/I3R761 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/523841:E6P09_RS01650 ^@ http://purl.uniprot.org/uniprot/I3R641 ^@ Function ^@ Part of a potassium transport system. http://togogenome.org/gene/523841:E6P09_RS05675 ^@ http://purl.uniprot.org/uniprot/I3R1Z2 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. http://togogenome.org/gene/523841:E6P09_RS12805 ^@ http://purl.uniprot.org/uniprot/I3R8A9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/523841:E6P09_RS03720 ^@ http://purl.uniprot.org/uniprot/I3R0V9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family. http://togogenome.org/gene/523841:E6P09_RS14355 ^@ http://purl.uniprot.org/uniprot/I3R7F8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the CofD family.|||Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS13630 ^@ http://purl.uniprot.org/uniprot/I3R7U7 ^@ Similarity ^@ Belongs to the PNP/UDP phosphorylase family. http://togogenome.org/gene/523841:E6P09_RS16980 ^@ http://purl.uniprot.org/uniprot/M0IMU7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS11970 ^@ http://purl.uniprot.org/uniprot/I3R5I2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS12890 ^@ http://purl.uniprot.org/uniprot/I3R894 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family.|||Nucleus http://togogenome.org/gene/523841:E6P09_RS19085 ^@ http://purl.uniprot.org/uniprot/I3R931 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS14555 ^@ http://purl.uniprot.org/uniprot/I3R7C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS04600 ^@ http://purl.uniprot.org/uniprot/I3R1D1 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. http://togogenome.org/gene/523841:E6P09_RS14540 ^@ http://purl.uniprot.org/uniprot/I3R7C5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS04870 ^@ http://purl.uniprot.org/uniprot/I3R1I5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS18650 ^@ http://purl.uniprot.org/uniprot/I3R9J1 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/523841:E6P09_RS08550 ^@ http://purl.uniprot.org/uniprot/I3R3L1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the diaminopimelate epimerase family.|||Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS08635 ^@ http://purl.uniprot.org/uniprot/I3R3M8 ^@ Function|||Similarity ^@ Belongs to the HARP family.|||RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. http://togogenome.org/gene/523841:E6P09_RS00890 ^@ http://purl.uniprot.org/uniprot/I3R6I8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS05630 ^@ http://purl.uniprot.org/uniprot/I3R1Y4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the transcriptional regulatory CopG/NikR family.|||Binds 1 nickel ion per subunit.|||Transcriptional regulator. http://togogenome.org/gene/523841:E6P09_RS01770 ^@ http://purl.uniprot.org/uniprot/I3R617 ^@ Similarity ^@ Belongs to the HAM1 NTPase family. http://togogenome.org/gene/523841:E6P09_RS11835 ^@ http://purl.uniprot.org/uniprot/I3R5F6 ^@ Function|||Similarity ^@ Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.|||Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC), the main low-molecular-weight thiol compound instead of glutathione in halophilic archaea. http://togogenome.org/gene/523841:E6P09_RS11730 ^@ http://purl.uniprot.org/uniprot/I3R5D5 ^@ Function|||Similarity ^@ Belongs to the AdoMet synthase 2 family.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/523841:E6P09_RS01575 ^@ http://purl.uniprot.org/uniprot/Q2VEQ7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Catalyzes the stereospecific NAD(P)H-dependent reduction of 2-ketocarboxylic acids into the corresponding D-2-hydroxycarboxylic acids. Can use both NADPH or NADH as reductant, displaying a marked preference for NADPH over NADH. Shows a broad substrate specificity, although it displays a marked preference for the 2-ketocarboxylic acids having an unbranched chain of 4-5 carbon atoms.|||Homotetramer. http://togogenome.org/gene/523841:E6P09_RS04340 ^@ http://purl.uniprot.org/uniprot/I3R179 ^@ Similarity ^@ Belongs to the threonine aldolase family. http://togogenome.org/gene/523841:E6P09_RS13250 ^@ http://purl.uniprot.org/uniprot/I3R824 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523841:E6P09_RS11145 ^@ http://purl.uniprot.org/uniprot/I3R518 ^@ Similarity ^@ Belongs to the UPF0212 family. http://togogenome.org/gene/523841:E6P09_RS03430 ^@ http://purl.uniprot.org/uniprot/I3R0Q0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS09405 ^@ http://purl.uniprot.org/uniprot/I3R433 ^@ Similarity ^@ Belongs to the transcriptional regulator TrmB family. http://togogenome.org/gene/523841:E6P09_RS14005 ^@ http://purl.uniprot.org/uniprot/I3R7M6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||S-layer http://togogenome.org/gene/523841:E6P09_RS15180 ^@ http://purl.uniprot.org/uniprot/I3RAE0 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/523841:E6P09_RS03255 ^@ http://purl.uniprot.org/uniprot/I3R0L5 ^@ Cofactor|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family.|||Binds 2 iron ions per subunit. http://togogenome.org/gene/523841:E6P09_RS03310 ^@ http://purl.uniprot.org/uniprot/I3R0M7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||Involved in both the arginine and lysine biosynthetic pathways. http://togogenome.org/gene/523841:E6P09_RS01690 ^@ http://purl.uniprot.org/uniprot/I3R633 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/523841:E6P09_RS10745 ^@ http://purl.uniprot.org/uniprot/I3R4T9 ^@ Function|||Similarity ^@ Belongs to the TFIIB family.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/523841:E6P09_RS07865 ^@ http://purl.uniprot.org/uniprot/I3R372 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.|||Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction proceeds via a cis-phosphoenolate intermediate. http://togogenome.org/gene/523841:E6P09_RS05935 ^@ http://purl.uniprot.org/uniprot/I3R243 ^@ Function ^@ Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin. http://togogenome.org/gene/523841:E6P09_RS13890 ^@ http://purl.uniprot.org/uniprot/I3R7P9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges. http://togogenome.org/gene/523841:E6P09_RS04645 ^@ http://purl.uniprot.org/uniprot/I3R1E0 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the archaeal riboflavin kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS06075 ^@ http://purl.uniprot.org/uniprot/I3R272 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS17455 ^@ http://purl.uniprot.org/uniprot/A0A059TQY9|||http://purl.uniprot.org/uniprot/I3R9N1 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b family.|||Binds 2 heme groups per subunit.|||Cell membrane|||Membrane|||Probable multiprotein complex; a catalytic heterodimer of an alpha and beta chain is proposed to associate with additional subunits involved in membrane attachment and electron transfer.|||Proposed to confer antimycin sensitivity to the respiratory nitrate reductase.|||The respiratory membrane-bound nitrate reductase enzyme complex plays a role in generation of metabolic energy by using nitrate as a terminal electron acceptor during anaerobic conditions. Proposed membrane-embedded heme-iron subunit involved in a protonmotive Q-cycle mechanism-based electron transfer to the beta subunit. http://togogenome.org/gene/523841:E6P09_RS02015 ^@ http://purl.uniprot.org/uniprot/I3R5X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS12575 ^@ http://purl.uniprot.org/uniprot/I3R8F1 ^@ Similarity ^@ Belongs to the UPF0179 family. http://togogenome.org/gene/523841:E6P09_RS14175 ^@ http://purl.uniprot.org/uniprot/I3R7I8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS02370 ^@ http://purl.uniprot.org/uniprot/I3R5Q4 ^@ Caution|||Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the peroxidase family. Peroxidase/catalase subfamily.|||Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.|||Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.|||Homodimer or homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS12780 ^@ http://purl.uniprot.org/uniprot/I3R8B3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS17690 ^@ http://purl.uniprot.org/uniprot/I3R9T5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS07405 ^@ http://purl.uniprot.org/uniprot/A0A4P8P6Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS05320 ^@ http://purl.uniprot.org/uniprot/I3R1S5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/523841:E6P09_RS16150 ^@ http://purl.uniprot.org/uniprot/I3RB67 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/523841:E6P09_RS17175 ^@ http://purl.uniprot.org/uniprot/I3RAJ8 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/523841:E6P09_RS12210 ^@ http://purl.uniprot.org/uniprot/I3R8M4 ^@ Similarity ^@ Belongs to the dihydrofolate reductase family. http://togogenome.org/gene/523841:E6P09_RS05855 ^@ http://purl.uniprot.org/uniprot/I3R226 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/523841:E6P09_RS05580 ^@ http://purl.uniprot.org/uniprot/I3R1X4 ^@ Subunit ^@ Homotrimer. http://togogenome.org/gene/523841:E6P09_RS05685 ^@ http://purl.uniprot.org/uniprot/I3R1Z4 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/523841:E6P09_RS10375 ^@ http://purl.uniprot.org/uniprot/I3R4L8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS13040 ^@ http://purl.uniprot.org/uniprot/I3R864 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TmcA family.|||Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||nucleolus http://togogenome.org/gene/523841:E6P09_RS02870 ^@ http://purl.uniprot.org/uniprot/I3R8U0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRA-CH family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS13855 ^@ http://purl.uniprot.org/uniprot/I3R7Q6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/523841:E6P09_RS03715 ^@ http://purl.uniprot.org/uniprot/I3R0V8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/523841:E6P09_RS17580 ^@ http://purl.uniprot.org/uniprot/I3R9R0 ^@ Similarity ^@ Belongs to the selenium-binding protein family. http://togogenome.org/gene/523841:E6P09_RS04030 ^@ http://purl.uniprot.org/uniprot/I3R116 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Forms a complex with TatA.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/523841:E6P09_RS06310 ^@ http://purl.uniprot.org/uniprot/I3R2B6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS03805 ^@ http://purl.uniprot.org/uniprot/M0J3C0 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/523841:E6P09_RS16960 ^@ http://purl.uniprot.org/uniprot/I3RAP0 ^@ Similarity ^@ To bacterial alkanal monooxygenase alpha and beta chains. http://togogenome.org/gene/523841:E6P09_RS12060 ^@ http://purl.uniprot.org/uniprot/I3R5K1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/523841:E6P09_RS04760 ^@ http://purl.uniprot.org/uniprot/I3R1G1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Cytoplasm|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/523841:E6P09_RS03010 ^@ http://purl.uniprot.org/uniprot/I3R8W9 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/523841:E6P09_RS09195 ^@ http://purl.uniprot.org/uniprot/I3R3Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS14490 ^@ http://purl.uniprot.org/uniprot/I3R7D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the halobacterial S-layer protein family.|||Cell membrane|||Membrane|||S-layer http://togogenome.org/gene/523841:E6P09_RS01040 ^@ http://purl.uniprot.org/uniprot/A0A059TWA6 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/523841:E6P09_RS10705 ^@ http://purl.uniprot.org/uniprot/I3R4T0 ^@ Similarity ^@ Belongs to the isochorismate synthase family. http://togogenome.org/gene/523841:E6P09_RS08360 ^@ http://purl.uniprot.org/uniprot/I3R3H2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS06975 ^@ http://purl.uniprot.org/uniprot/I3R2Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GDT1 family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS17910 ^@ http://purl.uniprot.org/uniprot/I3R9X6 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/523841:E6P09_RS17770 ^@ http://purl.uniprot.org/uniprot/I3R9V1 ^@ Caution|||Function|||Similarity ^@ Belongs to the TFIIB family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/523841:E6P09_RS13115 ^@ http://purl.uniprot.org/uniprot/I3R848 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/523841:E6P09_RS02530 ^@ http://purl.uniprot.org/uniprot/I3R5M0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS07120 ^@ http://purl.uniprot.org/uniprot/I3R2T0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.|||Belongs to the AAA ATPase family.|||Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.|||Cytoplasm|||Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets. http://togogenome.org/gene/523841:E6P09_RS02730 ^@ http://purl.uniprot.org/uniprot/I3R8R4 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/523841:E6P09_RS01420 ^@ http://purl.uniprot.org/uniprot/I3R688 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. http://togogenome.org/gene/523841:E6P09_RS06480 ^@ http://purl.uniprot.org/uniprot/I3R2F0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/523841:E6P09_RS11320 ^@ http://purl.uniprot.org/uniprot/I3R553 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/523841:E6P09_RS15480 ^@ http://purl.uniprot.org/uniprot/I3RA80 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AP endonuclease 2 family.|||Binds 3 Zn(2+) ions.|||Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. http://togogenome.org/gene/523841:E6P09_RS00615 ^@ http://purl.uniprot.org/uniprot/I3R6P4 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MobA family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.|||Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. http://togogenome.org/gene/523841:E6P09_RS10725 ^@ http://purl.uniprot.org/uniprot/I3R4T5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS04940 ^@ http://purl.uniprot.org/uniprot/M0J2R7 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/523841:E6P09_RS12235 ^@ http://purl.uniprot.org/uniprot/I3R8L9 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/523841:E6P09_RS10270 ^@ http://purl.uniprot.org/uniprot/I3R4J8 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/523841:E6P09_RS15310 ^@ http://purl.uniprot.org/uniprot/A0A059TZP7 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/523841:E6P09_RS00695 ^@ http://purl.uniprot.org/uniprot/I3R6M8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS18930 ^@ http://purl.uniprot.org/uniprot/I3R901 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/523841:E6P09_RS03755 ^@ http://purl.uniprot.org/uniprot/I3R0W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS14700 ^@ http://purl.uniprot.org/uniprot/A0A059TWU9|||http://purl.uniprot.org/uniprot/I3R794 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S8 family.|||Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.|||Probable secreted halophilic serine protease showing proteolytic activity toward the protease general substrate azocasein.|||Secreted http://togogenome.org/gene/523841:E6P09_RS00435 ^@ http://purl.uniprot.org/uniprot/I3R6S9 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/523841:E6P09_RS01760 ^@ http://purl.uniprot.org/uniprot/I3R619 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. BUD32 family.|||Binds 1 Fe(2+) ion per subunit.|||Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.|||Cytoplasm|||In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.|||In the N-terminal section; belongs to the KAE1 / TsaD family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. http://togogenome.org/gene/523841:E6P09_RS03875 ^@ http://purl.uniprot.org/uniprot/I3R0Y6 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).|||Cell membrane|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. http://togogenome.org/gene/523841:E6P09_RS13955 ^@ http://purl.uniprot.org/uniprot/I3R7N6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/523841:E6P09_RS03400 ^@ http://purl.uniprot.org/uniprot/I3R0P4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS09785 ^@ http://purl.uniprot.org/uniprot/I3R4A3 ^@ Similarity ^@ Belongs to the peptidase C56 family. http://togogenome.org/gene/523841:E6P09_RS11870 ^@ http://purl.uniprot.org/uniprot/I3R5G2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Mediates influx of magnesium ions.|||Membrane http://togogenome.org/gene/523841:E6P09_RS06215 ^@ http://purl.uniprot.org/uniprot/I3R298 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the THI4 family.|||Homooctamer; tetramer of dimers.|||Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS04305 ^@ http://purl.uniprot.org/uniprot/I3R171 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. http://togogenome.org/gene/523841:E6P09_RS06940 ^@ http://purl.uniprot.org/uniprot/I3R2P5 ^@ Function|||Similarity ^@ Belongs to the PEP-utilizing enzyme family.|||Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. http://togogenome.org/gene/523841:E6P09_RS03760 ^@ http://purl.uniprot.org/uniprot/I3R0W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS14460 ^@ http://purl.uniprot.org/uniprot/I3R7E0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS13790 ^@ http://purl.uniprot.org/uniprot/I3R7R6 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/523841:E6P09_RS18715 ^@ http://purl.uniprot.org/uniprot/I3R9K4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. Biotin synthase family.|||Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS13600 ^@ http://purl.uniprot.org/uniprot/I3R7V3 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/523841:E6P09_RS15565 ^@ http://purl.uniprot.org/uniprot/I3RBJ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS11405 ^@ http://purl.uniprot.org/uniprot/I3R572 ^@ Similarity ^@ Belongs to the SOS response-associated peptidase family. http://togogenome.org/gene/523841:E6P09_RS01755 ^@ http://purl.uniprot.org/uniprot/I3R620 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/523841:E6P09_RS04210 ^@ http://purl.uniprot.org/uniprot/I3R151 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS00605 ^@ http://purl.uniprot.org/uniprot/I3R6P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523841:E6P09_RS13090 ^@ http://purl.uniprot.org/uniprot/I3R853 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS12460 ^@ http://purl.uniprot.org/uniprot/I3R8H5 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/523841:E6P09_RS06920 ^@ http://purl.uniprot.org/uniprot/I3R2P1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS13905 ^@ http://purl.uniprot.org/uniprot/M0IQI7|||http://purl.uniprot.org/uniprot/P50557 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/523841:E6P09_RS05035 ^@ http://purl.uniprot.org/uniprot/I3R1L9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS07160 ^@ http://purl.uniprot.org/uniprot/I3R2T8 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/523841:E6P09_RS06900 ^@ http://purl.uniprot.org/uniprot/I3R2N7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS13065 ^@ http://purl.uniprot.org/uniprot/I3R858 ^@ Similarity ^@ Belongs to the ETF alpha-subunit/FixB family. http://togogenome.org/gene/523841:E6P09_RS16660 ^@ http://purl.uniprot.org/uniprot/I3RAW2 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/523841:E6P09_RS03500 ^@ http://purl.uniprot.org/uniprot/I3R0R3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS03810 ^@ http://purl.uniprot.org/uniprot/I3R0X4 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the NnrE/AIBP family.|||Binds 1 potassium ion per subunit.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS03315 ^@ http://purl.uniprot.org/uniprot/I3R0M8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. LysZ subfamily.|||Cytoplasm|||Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS06150 ^@ http://purl.uniprot.org/uniprot/I3R286 ^@ Similarity ^@ Belongs to the UPF0440 family. http://togogenome.org/gene/523841:E6P09_RS03035 ^@ http://purl.uniprot.org/uniprot/I3R8X4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS03050 ^@ http://purl.uniprot.org/uniprot/I3R8X7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS06195 ^@ http://purl.uniprot.org/uniprot/I3R294 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS03725 ^@ http://purl.uniprot.org/uniprot/I3R0W0 ^@ Function|||Similarity ^@ Belongs to the eIF-6 family.|||Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. http://togogenome.org/gene/523841:E6P09_RS07275 ^@ http://purl.uniprot.org/uniprot/I3R2W1 ^@ Function|||Similarity ^@ Belongs to the methylglyoxal synthase family.|||Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. http://togogenome.org/gene/523841:E6P09_RS06930 ^@ http://purl.uniprot.org/uniprot/I3R2P3 ^@ Function|||Similarity ^@ Belongs to the group II decarboxylase family. MfnA subfamily.|||Catalyzes the decarboxylation of L-aspartate to produce beta-alanine. http://togogenome.org/gene/523841:E6P09_RS06765 ^@ http://purl.uniprot.org/uniprot/I3R2L0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/523841:E6P09_RS13095 ^@ http://purl.uniprot.org/uniprot/I3R852 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/523841:E6P09_RS04165 ^@ http://purl.uniprot.org/uniprot/I3R142 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/523841:E6P09_RS12300 ^@ http://purl.uniprot.org/uniprot/I3R8K7 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.|||Cytoplasm|||Homotetramer.|||Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.|||There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors. http://togogenome.org/gene/523841:E6P09_RS04970 ^@ http://purl.uniprot.org/uniprot/I3R1K5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS06435 ^@ http://purl.uniprot.org/uniprot/I3R2E1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SPT5 family.|||Belongs to the archaeal Spt5 family.|||Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).|||Stimulates transcription elongation. http://togogenome.org/gene/523841:E6P09_RS09040 ^@ http://purl.uniprot.org/uniprot/I3R3V8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS01795 ^@ http://purl.uniprot.org/uniprot/I3R612 ^@ Function ^@ Part of a potassium transport system. http://togogenome.org/gene/523841:E6P09_RS04810 ^@ http://purl.uniprot.org/uniprot/I3R1H3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/523841:E6P09_RS03705 ^@ http://purl.uniprot.org/uniprot/I3R0V6 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/523841:E6P09_RS04000 ^@ http://purl.uniprot.org/uniprot/I3R111 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/523841:E6P09_RS06420 ^@ http://purl.uniprot.org/uniprot/I3R2D8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DtdA deacylase family.|||Binds 2 Zn(2+) ions per subunit.|||D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.|||Monomer. http://togogenome.org/gene/523841:E6P09_RS10870 ^@ http://purl.uniprot.org/uniprot/I3R4W4 ^@ Function|||Similarity ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. http://togogenome.org/gene/523841:E6P09_RS17045 ^@ http://purl.uniprot.org/uniprot/M0IKV0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS06245 ^@ http://purl.uniprot.org/uniprot/I3R2A4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).|||Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS01655 ^@ http://purl.uniprot.org/uniprot/I3R640 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/523841:E6P09_RS02635 ^@ http://purl.uniprot.org/uniprot/I3R8P5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/523841:E6P09_RS16505 ^@ http://purl.uniprot.org/uniprot/I3RAZ3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/523841:E6P09_RS02820 ^@ http://purl.uniprot.org/uniprot/I3R8T1 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/523841:E6P09_RS00075 ^@ http://purl.uniprot.org/uniprot/I3R6Z6 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/523841:E6P09_RS04585 ^@ http://purl.uniprot.org/uniprot/I3R1C8 ^@ Function|||Similarity ^@ Belongs to the V-ATPase E subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/523841:E6P09_RS11485 ^@ http://purl.uniprot.org/uniprot/Q02240 ^@ Disruption Phenotype|||Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A minor component of the gas vesicle (GV), may play a role in transcription and/or RNA stability and/or in GV assembly. Gas vesicles are small, hollow, gas filled protein structures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated shallow brine pools of their habitat.|||Belongs to the gas vesicle GvpO family.|||Cytoplasm|||Encoded in a 14-gene locus called mc-vac.|||Expressed from a single promoter upstream of gvpA; most transcripts stop at the gvpA terminator, with low read-through into downstream gvpC-gvpN-gvpO. Expression starts in early stationary phase and is maximal in stationary phase (PubMed:7683649, PubMed:8757736). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736).|||Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.|||Forms homodimers, forms a GvpN-GvpO heterodimer, interacts with GvpC, GvpF, GvpI and GvpL, might interact with GvpA.|||Gas vesicle|||No longer makes gas vesicles in H.volcanii; cells translate GvpA but do not make gas vesicles. http://togogenome.org/gene/523841:E6P09_RS10395 ^@ http://purl.uniprot.org/uniprot/I3R4M2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS14470 ^@ http://purl.uniprot.org/uniprot/I3R7D8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the anthranilate synthase component I family.|||Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).|||Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. http://togogenome.org/gene/523841:E6P09_RS17440 ^@ http://purl.uniprot.org/uniprot/I3R9M8 ^@ Activity Regulation|||Cofactor|||Function|||Induction|||Subcellular Location Annotation|||Subunit ^@ Binds 1 [3Fe-4S] cluster per subunit.|||Binds 3 [4Fe-4S] clusters per subunit.|||By nitrate.|||Cell membrane|||Inhibited by cyanide, azide and antimycin A. Enzyme stability is not dependent on salt concentration.|||Probable multiprotein complex; a catalytic heterodimer of an alpha and beta chain is proposed to associate with additional subunits involved in membrane attachment and electron transfer.|||The respiratory membrane-bound nitrate reductase enzyme complex plays a role in generation of metabolic energy by using nitrate as a terminal electron acceptor during anaerobic conditions. The beta chain is an electron transfer unit containing four cysteine clusters involved in the formation of iron-sulfur centers. http://togogenome.org/gene/523841:E6P09_RS10890 ^@ http://purl.uniprot.org/uniprot/I3R4W8 ^@ Similarity ^@ Belongs to the acetolactate synthase small subunit family. http://togogenome.org/gene/523841:E6P09_RS08745 ^@ http://purl.uniprot.org/uniprot/I3R3Q1 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/523841:E6P09_RS12610 ^@ http://purl.uniprot.org/uniprot/I3R8E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DsbB family. BdbC subfamily.|||Membrane http://togogenome.org/gene/523841:E6P09_RS14745 ^@ http://purl.uniprot.org/uniprot/I3R785 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvT family.|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/523841:E6P09_RS05850 ^@ http://purl.uniprot.org/uniprot/I3R225 ^@ Cofactor ^@ The crystal structure with reduced Cu(1+) has also been determined. http://togogenome.org/gene/523841:E6P09_RS01675 ^@ http://purl.uniprot.org/uniprot/A0A059TN56|||http://purl.uniprot.org/uniprot/I3R636 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MobA family.|||Cytoplasm|||The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.|||Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. http://togogenome.org/gene/523841:E6P09_RS07085 ^@ http://purl.uniprot.org/uniprot/I3R2S3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS19150 ^@ http://purl.uniprot.org/uniprot/I3R944 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/523841:E6P09_RS12940 ^@ http://purl.uniprot.org/uniprot/I3R884 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/523841:E6P09_RS04435 ^@ http://purl.uniprot.org/uniprot/I3R199 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS11190 ^@ http://purl.uniprot.org/uniprot/I3R526 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/523841:E6P09_RS00600 ^@ http://purl.uniprot.org/uniprot/I3R6P7 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.|||In the N-terminal section; belongs to the malic enzymes family. http://togogenome.org/gene/523841:E6P09_RS00045 ^@ http://purl.uniprot.org/uniprot/I3R702 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS06070 ^@ http://purl.uniprot.org/uniprot/I3R271 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS03965 ^@ http://purl.uniprot.org/uniprot/I3R104 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. http://togogenome.org/gene/523841:E6P09_RS12850 ^@ http://purl.uniprot.org/uniprot/I3R8A1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/523841:E6P09_RS15865 ^@ http://purl.uniprot.org/uniprot/I3RBD0 ^@ Similarity ^@ Belongs to the FabD family. http://togogenome.org/gene/523841:E6P09_RS01495 ^@ http://purl.uniprot.org/uniprot/I3R673 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/523841:E6P09_RS09915 ^@ http://purl.uniprot.org/uniprot/I3R4C8 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/523841:E6P09_RS13590 ^@ http://purl.uniprot.org/uniprot/I3R7V5 ^@ Similarity ^@ Belongs to the PEPCase type 1 family. http://togogenome.org/gene/523841:E6P09_RS09030 ^@ http://purl.uniprot.org/uniprot/I3R3V6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS08915 ^@ http://purl.uniprot.org/uniprot/I3R3T2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 4 family.|||Binds 1 zinc ion per subunit.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/523841:E6P09_RS06425 ^@ http://purl.uniprot.org/uniprot/M0J032|||http://purl.uniprot.org/uniprot/Q9V2S6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/523841:E6P09_RS04540 ^@ http://purl.uniprot.org/uniprot/I3R1B9 ^@ Similarity ^@ Belongs to the ETF alpha-subunit/FixB family. http://togogenome.org/gene/523841:E6P09_RS07010 ^@ http://purl.uniprot.org/uniprot/I3R2Q9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/523841:E6P09_RS18410 ^@ http://purl.uniprot.org/uniprot/I3R9E1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS04725 ^@ http://purl.uniprot.org/uniprot/I3R1F6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.|||Cell membrane|||Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/523841:E6P09_RS07040 ^@ http://purl.uniprot.org/uniprot/M0IZA1 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/523841:E6P09_RS17415 ^@ http://purl.uniprot.org/uniprot/I3R9M3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS00230 ^@ http://purl.uniprot.org/uniprot/M0IUQ8 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/523841:E6P09_RS12945 ^@ http://purl.uniprot.org/uniprot/I3R883 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/523841:E6P09_RS17940 ^@ http://purl.uniprot.org/uniprot/I3R9Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS03980 ^@ http://purl.uniprot.org/uniprot/I3R107 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.|||Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. http://togogenome.org/gene/523841:E6P09_RS14545 ^@ http://purl.uniprot.org/uniprot/I3R7C4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS15880 ^@ http://purl.uniprot.org/uniprot/I3RBC7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS16320 ^@ http://purl.uniprot.org/uniprot/I3RB32 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/523841:E6P09_RS06385 ^@ http://purl.uniprot.org/uniprot/I3R2D0 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/523841:E6P09_RS13275 ^@ http://purl.uniprot.org/uniprot/I3R819 ^@ Similarity ^@ Belongs to the transcriptional regulator TrmB family. http://togogenome.org/gene/523841:E6P09_RS10615 ^@ http://purl.uniprot.org/uniprot/I3R4R3 ^@ Similarity|||Subunit ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Homohexamer. http://togogenome.org/gene/523841:E6P09_RS14780 ^@ http://purl.uniprot.org/uniprot/I3R777 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS12375 ^@ http://purl.uniprot.org/uniprot/M0IS78 ^@ Cofactor|||Similarity ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/523841:E6P09_RS10775 ^@ http://purl.uniprot.org/uniprot/I3R4U5 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/523841:E6P09_RS13930 ^@ http://purl.uniprot.org/uniprot/I3R7P1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/523841:E6P09_RS03020 ^@ http://purl.uniprot.org/uniprot/M0J4V4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/523841:E6P09_RS09035 ^@ http://purl.uniprot.org/uniprot/I3R3V7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS11515 ^@ http://purl.uniprot.org/uniprot/M0J609|||http://purl.uniprot.org/uniprot/Q02231 ^@ Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A minor component of the gas vesicle, may be involved in preventing GvpA aggregation during gas vesicle nucleation (By similarity). Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat (By similarity).|||Belongs to the gas vesicle GvpF/GvpL family.|||Binds GvpA.|||Encoded in a 14-gene locus called mc-vac.|||Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.|||Gas vesicle|||Transcribed from early-log phase, decreases as cells enter stationary phase, probably as a long gvpF-gvpM RNA (PubMed:1404376). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736). Accumulates in exponential but not stationary phase (at protein level) (PubMed:12864859).|||Vesicle http://togogenome.org/gene/523841:E6P09_RS05075 ^@ http://purl.uniprot.org/uniprot/I3R1M7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/523841:E6P09_RS16950 ^@ http://purl.uniprot.org/uniprot/I3RAP3 ^@ Similarity|||Subunit ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Homohexamer. http://togogenome.org/gene/523841:E6P09_RS11535 ^@ http://purl.uniprot.org/uniprot/M0J5I9|||http://purl.uniprot.org/uniprot/Q02235 ^@ Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A minor component of the gas vesicle, proteins GvpF to GvpM might be involved in nucleating gas vesicle formation (By similarity). Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat (By similarity).|||Belongs to the gas vesicle GvpA family.|||Encoded in a 14-gene locus called mc-vac.|||Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.|||Gas vesicle|||GvpF to GvpM interact with each other in vitro, and may form multi-subunit complex(es). Interacts with GvpA.|||Transcribed from early-log phase, decreases as cells enter stationary phase, probably as a long gvpF-gvpM RNA (PubMed:1404376). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736). http://togogenome.org/gene/523841:E6P09_RS02785 ^@ http://purl.uniprot.org/uniprot/I3R8S4 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily. http://togogenome.org/gene/523841:E6P09_RS16285 ^@ http://purl.uniprot.org/uniprot/I3RB40 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the urocanase family.|||Binds 1 NAD(+) per subunit.|||Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS06185 ^@ http://purl.uniprot.org/uniprot/I3R292 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruD family.|||Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs. http://togogenome.org/gene/523841:E6P09_RS16105 ^@ http://purl.uniprot.org/uniprot/I3RB77 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS05910 ^@ http://purl.uniprot.org/uniprot/I3R237 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/523841:E6P09_RS08570 ^@ http://purl.uniprot.org/uniprot/I3R3L5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/523841:E6P09_RS09850 ^@ http://purl.uniprot.org/uniprot/I3R4B5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homotetramer; dimer of dimers.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/523841:E6P09_RS11585 ^@ http://purl.uniprot.org/uniprot/I3R5A9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/523841:E6P09_RS00810 ^@ http://purl.uniprot.org/uniprot/I3R6K5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS03645 ^@ http://purl.uniprot.org/uniprot/I3R0U4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS17700 ^@ http://purl.uniprot.org/uniprot/I3R9T7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS08485 ^@ http://purl.uniprot.org/uniprot/I3R3J8 ^@ Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/523841:E6P09_RS05740 ^@ http://purl.uniprot.org/uniprot/I3R204 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523841:E6P09_RS01295 ^@ http://purl.uniprot.org/uniprot/I3R6B2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS05045 ^@ http://purl.uniprot.org/uniprot/I3R1M1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M54 family.|||Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.|||Monomer.|||Probable zinc metalloprotease whose natural substrate is unknown. http://togogenome.org/gene/523841:E6P09_RS04680 ^@ http://purl.uniprot.org/uniprot/I3R1E7 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS01980 ^@ http://purl.uniprot.org/uniprot/I3R5Y0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS07300 ^@ http://purl.uniprot.org/uniprot/I3R2W6 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/523841:E6P09_RS18865 ^@ http://purl.uniprot.org/uniprot/I3R8Y7 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/523841:E6P09_RS14900 ^@ http://purl.uniprot.org/uniprot/I3R754 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/523841:E6P09_RS07975 ^@ http://purl.uniprot.org/uniprot/I3R394 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS11530 ^@ http://purl.uniprot.org/uniprot/Q02234 ^@ Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gas vesicle GvpI family.|||Encoded in a 14-gene locus called mc-vac.|||Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.|||Gas vesicle|||GvpF to GvpM interact with each other in vitro, and may form multi-subunit complex(es). Interacts with GvpC and GvpO.|||Proteins GvpF to GvpM might be involved in nucleating gas vesicle formation. A minor component of the gas vesicle (By similarity). Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat (By similarity).|||Transcribed from early-log phase, decreases as cells enter stationary phase, probably as a long gvpF-gvpM RNA (PubMed:1404376). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736). http://togogenome.org/gene/523841:E6P09_RS04605 ^@ http://purl.uniprot.org/uniprot/I3R1D2 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. http://togogenome.org/gene/523841:E6P09_RS01045 ^@ http://purl.uniprot.org/uniprot/I3R6G0 ^@ Similarity ^@ In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/523841:E6P09_RS13010 ^@ http://purl.uniprot.org/uniprot/I3R870 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the archaeal MetE family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown. http://togogenome.org/gene/523841:E6P09_RS13420 ^@ http://purl.uniprot.org/uniprot/I3R7Y6 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/523841:E6P09_RS15470 ^@ http://purl.uniprot.org/uniprot/I3RA82 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/523841:E6P09_RS03740 ^@ http://purl.uniprot.org/uniprot/I3R0W3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/523841:E6P09_RS06135 ^@ http://purl.uniprot.org/uniprot/I3R283 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/523841:E6P09_RS00590 ^@ http://purl.uniprot.org/uniprot/M0IUG4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||S-layer http://togogenome.org/gene/523841:E6P09_RS12110 ^@ http://purl.uniprot.org/uniprot/I3R5L0 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/523841:E6P09_RS06200 ^@ http://purl.uniprot.org/uniprot/I3R295 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the dCTP deaminase family.|||Catalyzes the deamination of dCTP to dUTP.|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS08240 ^@ http://purl.uniprot.org/uniprot/I3R3E6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/523841:E6P09_RS02470 ^@ http://purl.uniprot.org/uniprot/I3R5N2 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/523841:E6P09_RS08565 ^@ http://purl.uniprot.org/uniprot/I3R3L4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapB family.|||Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. http://togogenome.org/gene/523841:E6P09_RS08720 ^@ http://purl.uniprot.org/uniprot/I3R3P6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/523841:E6P09_RS03325 ^@ http://purl.uniprot.org/uniprot/I3R0N0 ^@ Similarity ^@ Belongs to the RimK family. LysX subfamily. http://togogenome.org/gene/523841:E6P09_RS17780 ^@ http://purl.uniprot.org/uniprot/I3R9V3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS14935 ^@ http://purl.uniprot.org/uniprot/I3R746 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS14150 ^@ http://purl.uniprot.org/uniprot/I3R7J3 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/523841:E6P09_RS17765 ^@ http://purl.uniprot.org/uniprot/I3R9V0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS02655 ^@ http://purl.uniprot.org/uniprot/I3R8P9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS16100 ^@ http://purl.uniprot.org/uniprot/I3RB79 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS16215 ^@ http://purl.uniprot.org/uniprot/M0IKE1 ^@ Function|||Similarity ^@ Belongs to the CobB/CobQ family. CobQ subfamily.|||Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. http://togogenome.org/gene/523841:E6P09_RS02025 ^@ http://purl.uniprot.org/uniprot/I3R5X0 ^@ Caution|||Function|||Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS15360 ^@ http://purl.uniprot.org/uniprot/I3RAA6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS06850 ^@ http://purl.uniprot.org/uniprot/I3R2M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS04055 ^@ http://purl.uniprot.org/uniprot/I3R121 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.|||Has ATPase and non-specific DNA-binding activities. http://togogenome.org/gene/523841:E6P09_RS03065 ^@ http://purl.uniprot.org/uniprot/I3R8Y0 ^@ Function|||Similarity ^@ Belongs to the LDH/MDH superfamily.|||Catalyzes the reversible oxidation of malate to oxaloacetate. http://togogenome.org/gene/523841:E6P09_RS00955 ^@ http://purl.uniprot.org/uniprot/I3R6H7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS03735 ^@ http://purl.uniprot.org/uniprot/M0J542 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin alpha subunit family.|||Belongs to the prefoldin subunit alpha family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/523841:E6P09_RS04015 ^@ http://purl.uniprot.org/uniprot/I3R113 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.|||Cell membrane|||Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS05260 ^@ http://purl.uniprot.org/uniprot/I3R1R3 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.|||Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. http://togogenome.org/gene/523841:E6P09_RS02670 ^@ http://purl.uniprot.org/uniprot/I3R8Q2 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/523841:E6P09_RS05220 ^@ http://purl.uniprot.org/uniprot/I3R1Q5 ^@ Similarity ^@ Belongs to the serine/threonine dehydratase family. http://togogenome.org/gene/523841:E6P09_RS11610 ^@ http://purl.uniprot.org/uniprot/I3R5B3 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family.|||Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). http://togogenome.org/gene/523841:E6P09_RS08325 ^@ http://purl.uniprot.org/uniprot/I3R3G4 ^@ Function ^@ Part of a potassium transport system. http://togogenome.org/gene/523841:E6P09_RS07915 ^@ http://purl.uniprot.org/uniprot/I3R382 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS08170 ^@ http://purl.uniprot.org/uniprot/I3R3D3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatA/E family.|||Cell membrane|||Forms a complex with TatC.|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. http://togogenome.org/gene/523841:E6P09_RS11130 ^@ http://purl.uniprot.org/uniprot/I3R515 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS17875 ^@ http://purl.uniprot.org/uniprot/I3R9W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS13900 ^@ http://purl.uniprot.org/uniprot/I3R7P7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/523841:E6P09_RS13750 ^@ http://purl.uniprot.org/uniprot/I3R7S4 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily. http://togogenome.org/gene/523841:E6P09_RS05735 ^@ http://purl.uniprot.org/uniprot/I3R203 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523841:E6P09_RS01670 ^@ http://purl.uniprot.org/uniprot/I3R637 ^@ Activity Regulation|||Cofactor|||Function|||Induction|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Binds 1 siroheme per subunit.|||Catalyzes the reduction of nitrite to ammonium in the nitrate assimilation pathway, using ferredoxin as the electron donor. Can use reduced methyl viologen but neither NADPH nor NADH as electron donors.|||Enzyme stability and activity depend upon the salt concentration.|||Inhibited by cyanide and azide.|||Monomer.|||Repressed by the presence of ammonium as nitrogen source. http://togogenome.org/gene/523841:E6P09_RS12630 ^@ http://purl.uniprot.org/uniprot/I3R8E1 ^@ Similarity ^@ Belongs to the alkylbase DNA glycosidase AlkA family. http://togogenome.org/gene/523841:E6P09_RS05805 ^@ http://purl.uniprot.org/uniprot/I3R217 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AP endonuclease 2 family.|||Binds 3 Zn(2+) ions.|||Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. http://togogenome.org/gene/523841:E6P09_RS00865 ^@ http://purl.uniprot.org/uniprot/I3R6J3 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/523841:E6P09_RS04080 ^@ http://purl.uniprot.org/uniprot/I3R125 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose 5-phosphate isomerase family.|||Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS02600 ^@ http://purl.uniprot.org/uniprot/I3R8N8 ^@ Function ^@ Protects DNA against thermal denaturation and modulates transcription. http://togogenome.org/gene/523841:E6P09_RS09830 ^@ http://purl.uniprot.org/uniprot/I3R4B2 ^@ Function|||Similarity ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. http://togogenome.org/gene/523841:E6P09_RS02835 ^@ http://purl.uniprot.org/uniprot/I3R8T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/523841:E6P09_RS18045 ^@ http://purl.uniprot.org/uniprot/I3RA07 ^@ Subunit ^@ Homotrimer. http://togogenome.org/gene/523841:E6P09_RS07450 ^@ http://purl.uniprot.org/uniprot/I3R2Z7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS11330 ^@ http://purl.uniprot.org/uniprot/I3R556 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS15155 ^@ http://purl.uniprot.org/uniprot/I3RAE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523841:E6P09_RS00995 ^@ http://purl.uniprot.org/uniprot/I3R6G9 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/523841:E6P09_RS06415 ^@ http://purl.uniprot.org/uniprot/I3R2D7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS12350 ^@ http://purl.uniprot.org/uniprot/I3R8J7 ^@ Similarity ^@ Belongs to the Nth/MutY family. http://togogenome.org/gene/523841:E6P09_RS07060 ^@ http://purl.uniprot.org/uniprot/I3R2R8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Golgi apparatus|||Lysosome http://togogenome.org/gene/523841:E6P09_RS08950 ^@ http://purl.uniprot.org/uniprot/I3R3T9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aTrm56 family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs. http://togogenome.org/gene/523841:E6P09_RS12010 ^@ http://purl.uniprot.org/uniprot/I3R5J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523841:E6P09_RS17460 ^@ http://purl.uniprot.org/uniprot/I3R9N2 ^@ Cofactor|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds 1 [2Fe-2S] cluster per subunit.|||Cell membrane|||Probable multiprotein complex; a catalytic heterodimer of an alpha and beta chain is proposed to associate with additional subunits involved in membrane attachment and electron transfer.|||The respiratory membrane-bound nitrate reductase enzyme complex plays a role in generation of metabolic energy by using nitrate as a terminal electron acceptor during anaerobic conditions. Proposed Rieske subunit involved in a protonmotive Q-cycle mechanism-based electron transfer electrons to the beta subunit. http://togogenome.org/gene/523841:E6P09_RS08520 ^@ http://purl.uniprot.org/uniprot/I3R3K5 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/523841:E6P09_RS00635 ^@ http://purl.uniprot.org/uniprot/I3R6P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NrfD family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS00170 ^@ http://purl.uniprot.org/uniprot/I3R6X8 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/523841:E6P09_RS08405 ^@ http://purl.uniprot.org/uniprot/I3R3I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523841:E6P09_RS11520 ^@ http://purl.uniprot.org/uniprot/Q02232 ^@ Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gas vesicle GvpG family.|||Encoded in a 14-gene locus called mc-vac.|||Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.|||Gas vesicle|||GvpF to GvpM interact with each other in vitro, and may form multi-subunit complex(es).|||Proteins GvpF to GvpM might be involved in nucleating gas vesicle formation. A minor component of the gas vesicle (By similarity). Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat (By similarity).|||Transcribed from early-log phase, decreases as cells enter stationary phase, probably as a long gvpF-gvpM RNA (PubMed:1404376). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736). http://togogenome.org/gene/523841:E6P09_RS08395 ^@ http://purl.uniprot.org/uniprot/I3R3H9 ^@ Function|||Similarity ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.|||May catalyze a purine salvage reaction, the substrate is unknown. http://togogenome.org/gene/523841:E6P09_RS09110 ^@ http://purl.uniprot.org/uniprot/I3R3X2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Archaeal flagellum|||Belongs to the archaeal flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella. http://togogenome.org/gene/523841:E6P09_RS03280 ^@ http://purl.uniprot.org/uniprot/I3R0M1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/523841:E6P09_RS12245 ^@ http://purl.uniprot.org/uniprot/I3R8L7 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/523841:E6P09_RS04750 ^@ http://purl.uniprot.org/uniprot/I3R1F9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/523841:E6P09_RS03950 ^@ http://purl.uniprot.org/uniprot/I3R101 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.|||Belongs to the Holliday junction resolvase Hjc family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS06845 ^@ http://purl.uniprot.org/uniprot/I3R2M6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the YjjX NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/523841:E6P09_RS00715 ^@ http://purl.uniprot.org/uniprot/M0IUD4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ThiC family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. http://togogenome.org/gene/523841:E6P09_RS05125 ^@ http://purl.uniprot.org/uniprot/I3R1N7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS06290 ^@ http://purl.uniprot.org/uniprot/I3R2B2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/523841:E6P09_RS01340 ^@ http://purl.uniprot.org/uniprot/I3R6A4 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase Pus10 family.|||Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/523841:E6P09_RS12930 ^@ http://purl.uniprot.org/uniprot/I3R886 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/523841:E6P09_RS09825 ^@ http://purl.uniprot.org/uniprot/I3R4B1 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. http://togogenome.org/gene/523841:E6P09_RS13885 ^@ http://purl.uniprot.org/uniprot/I3R7Q0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/523841:E6P09_RS02235 ^@ http://purl.uniprot.org/uniprot/I3R5S7 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS17640 ^@ http://purl.uniprot.org/uniprot/I3R9S2 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/523841:E6P09_RS03135 ^@ http://purl.uniprot.org/uniprot/I3R0J3 ^@ Similarity ^@ Belongs to the beta-eliminating lyase family. http://togogenome.org/gene/523841:E6P09_RS12820 ^@ http://purl.uniprot.org/uniprot/I3R8A6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the RNA polymerase complex. http://togogenome.org/gene/523841:E6P09_RS09435 ^@ http://purl.uniprot.org/uniprot/I3R438 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/523841:E6P09_RS03730 ^@ http://purl.uniprot.org/uniprot/I3R0W1 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL20 family.|||Part of the 50S ribosomal subunit. Binds 23S rRNA. http://togogenome.org/gene/523841:E6P09_RS11280 ^@ http://purl.uniprot.org/uniprot/M0J9R5|||http://purl.uniprot.org/uniprot/Q9HHB9 ^@ Function|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family. http://togogenome.org/gene/523841:E6P09_RS14395 ^@ http://purl.uniprot.org/uniprot/I3R7F0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS03390 ^@ http://purl.uniprot.org/uniprot/I3R0P2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS11060 ^@ http://purl.uniprot.org/uniprot/I3R501 ^@ Function ^@ Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone. http://togogenome.org/gene/523841:E6P09_RS13895 ^@ http://purl.uniprot.org/uniprot/I3R7P8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||Located at the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/523841:E6P09_RS07970 ^@ http://purl.uniprot.org/uniprot/I3R393 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4 family.|||Membrane http://togogenome.org/gene/523841:E6P09_RS13660 ^@ http://purl.uniprot.org/uniprot/I3R7U1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/523841:E6P09_RS00760 ^@ http://purl.uniprot.org/uniprot/I3R6L5 ^@ Cofactor ^@ Binds 1 copper ion per subunit. http://togogenome.org/gene/523841:E6P09_RS10290 ^@ http://purl.uniprot.org/uniprot/I3R4K2 ^@ Similarity ^@ Belongs to the UPF0145 family. http://togogenome.org/gene/523841:E6P09_RS03750 ^@ http://purl.uniprot.org/uniprot/I3R0W5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/523841:E6P09_RS14850 ^@ http://purl.uniprot.org/uniprot/I3R764 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/523841:E6P09_RS11500 ^@ http://purl.uniprot.org/uniprot/M0J8S6|||http://purl.uniprot.org/uniprot/P23761 ^@ Domain|||Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gas vesicle GvpA family.|||Encoded in a 14-gene locus called mc-vac.|||Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.|||Gas vesicle shell|||Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. During planktonic growth they allow positioning of the organism at a favorable depth for light or nutrient acquisition. GvpA forms the protein shell (PubMed:1703266, PubMed:1282192, PubMed:21542854). This gene replaces p-gvpA of H.salinarum very poorly, only about 1% of GVs are formed; the few gas vesicles formed are quite strong with a very high critical collapse pressure (CCP) of 0.213 MPa (PubMed:12167531).|||Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. During planktonic growth they allow positioning of the organism at a favorable depth for light or nutrient acquisition. GvpA forms the protein shell.|||Infrared spectra studies suggest the major structural elements are 47% alpha-helix and 25% antiparallel beta-strands; it is thought the beta-strands make the hydrophobic interior surface (PubMed:21542854).|||The gas vesicle shell is 2 nm thick and consists of a single layer of this protein. It forms helical ribs nearly perpendicular to the long axis of the vesicle (By similarity). Modeled as antiparallel homodimers (PubMed:21542854).|||The gas vesicle shell is 2 nm thick and consists of a single layer of this protein. It forms helical ribs nearly perpendicular to the long axis of the vesicle.|||Transcription is controlled by the GvpD-GvpE pair (PubMed:8757736, PubMed:12864859) (Probable). Transcripts are maximal at the beginning of stationary phase. Gas vesicle formation is maximally induced in stationary phase when grown in 20-25% total salt (NaCl, MgSO(4), KCl) (at protein level) (PubMed:1703266, PubMed:1282192, PubMed:8757736). Expressed from a single promoter upstream of gvpA; most transcripts stop at the gvpA terminator, with low read-through into downstream gvpC-gvpN-gvpO. Expression starts in early stationary phase and is maximal in stationary phase (PubMed:7683649, PubMed:8757736, PubMed:12864859). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736). http://togogenome.org/gene/523841:E6P09_RS14435 ^@ http://purl.uniprot.org/uniprot/I3R7E3 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/523841:E6P09_RS16200 ^@ http://purl.uniprot.org/uniprot/I3RB56 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/523841:E6P09_RS10685 ^@ http://purl.uniprot.org/uniprot/I3R4S7 ^@ Caution|||Function|||Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.|||Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523841:E6P09_RS00130 ^@ http://purl.uniprot.org/uniprot/I3R6Y5 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/523841:E6P09_RS07715 ^@ http://purl.uniprot.org/uniprot/I3R343 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS10145 ^@ http://purl.uniprot.org/uniprot/I3R4H3 ^@ Similarity ^@ Belongs to the FUN14 family. http://togogenome.org/gene/523841:E6P09_RS17445 ^@ http://purl.uniprot.org/uniprot/A0A059TYV5|||http://purl.uniprot.org/uniprot/I3R9M9 ^@ Activity Regulation|||Cofactor|||Function|||Induction|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.|||By nitrate.|||Cell membrane|||Exported by the Tat system.|||Inhibited by cyanide, azide and antimycin A. Enzyme stability is not dependent on salt concentration.|||Probable multiprotein complex; a catalytic heterodimer of an alpha and beta chain is proposed to associate with additional subunits involved in membrane attachment and electron transfer.|||The respiratory membrane-bound nitrate reductase enzyme complex plays a role in generation of metabolic energy by using nitrate as a terminal electron acceptor during anaerobic conditions. The alpha chain is the actual site of nitrate reduction. http://togogenome.org/gene/523841:E6P09_RS12830 ^@ http://purl.uniprot.org/uniprot/I3R8A5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL18 family. http://togogenome.org/gene/523841:E6P09_RS03870 ^@ http://purl.uniprot.org/uniprot/I3R0Y5 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. RfcS subfamily. http://togogenome.org/gene/523841:E6P09_RS15065 ^@ http://purl.uniprot.org/uniprot/I3R722 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/523841:E6P09_RS12270 ^@ http://purl.uniprot.org/uniprot/I3R8L2 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/523841:E6P09_RS06065 ^@ http://purl.uniprot.org/uniprot/I3R270 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 5 family. http://togogenome.org/gene/523841:E6P09_RS05000 ^@ http://purl.uniprot.org/uniprot/I3R1L2 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/523841:E6P09_RS09160 ^@ http://purl.uniprot.org/uniprot/I3R3Y3 ^@ Function|||Subunit ^@ Interacts with chemotaxis (Che) proteins as well as flagella accessory (Fla) proteins.|||Involved in taxis signal transduction. http://togogenome.org/gene/523841:E6P09_RS00720 ^@ http://purl.uniprot.org/uniprot/I3R6M3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS19100 ^@ http://purl.uniprot.org/uniprot/I3R934 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS19330 ^@ http://purl.uniprot.org/uniprot/I3R977 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS14550 ^@ http://purl.uniprot.org/uniprot/I3R7C3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS04650 ^@ http://purl.uniprot.org/uniprot/I3R1E1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DHBP synthase family.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS17880 ^@ http://purl.uniprot.org/uniprot/I3R9X0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS01190 ^@ http://purl.uniprot.org/uniprot/I3R6D1 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/523841:E6P09_RS16955 ^@ http://purl.uniprot.org/uniprot/I3RAP1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS04185 ^@ http://purl.uniprot.org/uniprot/I3R146 ^@ Cofactor|||Function ^@ Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Binds 1 zinc ion.|||Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/523841:E6P09_RS12450 ^@ http://purl.uniprot.org/uniprot/I3R8H7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA. http://togogenome.org/gene/523841:E6P09_RS08010 ^@ http://purl.uniprot.org/uniprot/I3R3A2 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/523841:E6P09_RS12625 ^@ http://purl.uniprot.org/uniprot/I3R8E2 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/523841:E6P09_RS10240 ^@ http://purl.uniprot.org/uniprot/I3R4J2 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS16905 ^@ http://purl.uniprot.org/uniprot/I3RAQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523841:E6P09_RS01360 ^@ http://purl.uniprot.org/uniprot/I3R6A0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecF subfamily.|||Cell membrane|||Involved in protein export.|||Membrane|||Part of the protein translocation apparatus. Forms a complex with SecD. http://togogenome.org/gene/523841:E6P09_RS04180 ^@ http://purl.uniprot.org/uniprot/I3R145 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||S-layer http://togogenome.org/gene/523841:E6P09_RS10330 ^@ http://purl.uniprot.org/uniprot/I3R4K9 ^@ Similarity ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. http://togogenome.org/gene/523841:E6P09_RS11325 ^@ http://purl.uniprot.org/uniprot/I3R555 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/523841:E6P09_RS03625 ^@ http://purl.uniprot.org/uniprot/I3R0U0 ^@ Similarity ^@ Belongs to the UPF0175 family. http://togogenome.org/gene/523841:E6P09_RS16580 ^@ http://purl.uniprot.org/uniprot/I3RAX8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family. http://togogenome.org/gene/523841:E6P09_RS06770 ^@ http://purl.uniprot.org/uniprot/I3R2L1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/523841:E6P09_RS08955 ^@ http://purl.uniprot.org/uniprot/I3R3U0 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the TFE family.|||Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.|||The winged helix domain is involved in binding to DNA in the preinitiation complex.|||Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes. http://togogenome.org/gene/523841:E6P09_RS18225 ^@ http://purl.uniprot.org/uniprot/I3RA46 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS05690 ^@ http://purl.uniprot.org/uniprot/I3R1Z5 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/523841:E6P09_RS06230 ^@ http://purl.uniprot.org/uniprot/I3R2A1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal phosphopantothenate synthetase family.|||Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.|||Homodimer. http://togogenome.org/gene/523841:E6P09_RS10005 ^@ http://purl.uniprot.org/uniprot/M0J7P7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523841:E6P09_RS10415 ^@ http://purl.uniprot.org/uniprot/I3R4M6 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/523841:E6P09_RS08260 ^@ http://purl.uniprot.org/uniprot/I3R3F0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/523841:E6P09_RS16885 ^@ http://purl.uniprot.org/uniprot/I3RAQ6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523841:E6P09_RS01170 ^@ http://purl.uniprot.org/uniprot/I3R6D5 ^@ Similarity ^@ Belongs to the archaeosine synthase type 1 family. http://togogenome.org/gene/523841:E6P09_RS11545 ^@ http://purl.uniprot.org/uniprot/M0J9K1|||http://purl.uniprot.org/uniprot/Q02237 ^@ Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gas vesicle GvpF/GvpL family.|||Encoded in a 14-gene locus called mc-vac.|||Expression of a 9.5 kb mc-vac DNA fragment containing 2 divergently transcribed regions (gvpD-gvpE-gvpF-gvpG-gvpH-gvpI-gvpJ-gvpK-gvpL-gvpM and gvpA-gvpC-gvpN-gvpO) allows H.volcanii to produce gas vesicles.|||Gas vesicle|||GvpF to GvpM interact with each other in vitro, and may form multi-subunit complex(es). Interacts with GvpC, GvpN and GvpO.|||Proteins GvpF to GvpM might be involved in nucleating gas vesicle formation. A minor component of the gas vesicle (By similarity). Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow positioning of halobacteria at the optimal depth for growth in the poorly aerated, shallow brine pools of their habitat (By similarity).|||Transcribed from early-log phase, decreases as cells enter stationary phase, probably as a long gvpF-gvpM RNA (PubMed:1404376). Highly expressed in 25% salt, poorly expressed in 15% salt, no gas vesicles are formed at 15% salt (PubMed:8757736).|||Vesicle http://togogenome.org/gene/523841:E6P09_RS07030 ^@ http://purl.uniprot.org/uniprot/I3R2R2 ^@ Similarity ^@ Belongs to the peptidase S9C family. http://togogenome.org/gene/523841:E6P09_RS03915 ^@ http://purl.uniprot.org/uniprot/I3R0Z4 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP phosphoribosyltransferase family. Long subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Feedback inhibited by histidine. http://togogenome.org/gene/523841:E6P09_RS13915 ^@ http://purl.uniprot.org/uniprot/I3R7P4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/523841:E6P09_RS12510 ^@ http://purl.uniprot.org/uniprot/I3R8G4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer.