http://togogenome.org/gene/523844:MSTHT_RS07540 ^@ http://purl.uniprot.org/uniprot/A0A0E3N986 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin alpha subunit family.|||Belongs to the prefoldin subunit alpha family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/523844:MSTHT_RS07900 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCD0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS05890 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEA4 ^@ Similarity ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. http://togogenome.org/gene/523844:MSTHT_RS11195 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9C6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/523844:MSTHT_RS01135 ^@ http://purl.uniprot.org/uniprot/A0A0E3KNT0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS06005 ^@ http://purl.uniprot.org/uniprot/A0A0E3N8V8 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.|||Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/523844:MSTHT_RS03970 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS10705 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQ38 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MtrH family.|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/523844:MSTHT_RS00790 ^@ http://purl.uniprot.org/uniprot/A0A0E3KNS0 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruD family.|||Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs. http://togogenome.org/gene/523844:MSTHT_RS11245 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9C8 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/523844:MSTHT_RS00405 ^@ http://purl.uniprot.org/uniprot/A0A0E3KNR0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS1 family. http://togogenome.org/gene/523844:MSTHT_RS10125 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ55 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/523844:MSTHT_RS02790 ^@ http://purl.uniprot.org/uniprot/A0A0E3N7Q8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/523844:MSTHT_RS00150 ^@ http://purl.uniprot.org/uniprot/A0A0E3KXV2 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/523844:MSTHT_RS03150 ^@ http://purl.uniprot.org/uniprot/A0A0E3KP09 ^@ Similarity ^@ Belongs to the peptidase C56 family. http://togogenome.org/gene/523844:MSTHT_RS11040 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9C0 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the archaeal riboflavin kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS05705 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS00990 ^@ http://purl.uniprot.org/uniprot/A0A0E3H888 ^@ Similarity ^@ Belongs to the UPF0758 family. http://togogenome.org/gene/523844:MSTHT_RS07000 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8W9 ^@ Function|||Similarity ^@ Belongs to the deoxyhypusine synthase family.|||Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. http://togogenome.org/gene/523844:MSTHT_RS11240 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ91 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.|||Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.|||Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS11420 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCT8 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS03280 ^@ http://purl.uniprot.org/uniprot/A0A0E3KP14 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase Pus10 family.|||Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/523844:MSTHT_RS10320 ^@ http://purl.uniprot.org/uniprot/A0A0E3NFE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS04100 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8K8 ^@ Similarity ^@ Belongs to the TlyA family. http://togogenome.org/gene/523844:MSTHT_RS01725 ^@ http://purl.uniprot.org/uniprot/A0A0E3ND35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/523844:MSTHT_RS05570 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCX1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the carbohydrate kinase PfkC family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS00530 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAK2 ^@ Similarity ^@ Belongs to the NifD/NifK/NifE/NifN family. http://togogenome.org/gene/523844:MSTHT_RS10150 ^@ http://purl.uniprot.org/uniprot/A0A0E3NFD3 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/523844:MSTHT_RS00090 ^@ http://purl.uniprot.org/uniprot/A0A0E3KNQ0 ^@ Similarity ^@ Belongs to the MtrH family. http://togogenome.org/gene/523844:MSTHT_RS01930 ^@ http://purl.uniprot.org/uniprot/A0A0E3N7H9 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS07355 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPP8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/523844:MSTHT_RS01170 ^@ http://purl.uniprot.org/uniprot/A0A0E3N9Y7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 1 family.|||Cell membrane|||FPO is composed of at least 12 different subunits. Subunits FpoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||FPO shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to quinones in the F(420)H(2):heterodisulfide oxidoreduction chain. The immediate electron acceptor for the enzyme in this species is believed to be methanophenazine. Couples the redox reaction to proton translocation (for every two electrons transferred, 0.9 hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS07340 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDA6 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/523844:MSTHT_RS04925 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS05310 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYM3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.|||Part of the RNA polymerase complex. http://togogenome.org/gene/523844:MSTHT_RS10045 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQ12 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS01255 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCZ0 ^@ Function|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family. http://togogenome.org/gene/523844:MSTHT_RS08395 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEY4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. Probably involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.|||Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA. http://togogenome.org/gene/523844:MSTHT_RS11485 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9D7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyltransferase superfamily. Fibrillarin family.|||Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.|||Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. http://togogenome.org/gene/523844:MSTHT_RS03395 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDK2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HCP family.|||Binds 1 [4Fe-4S] cluster.|||Binds 1 hybrid [4Fe-2O-2S] cluster.|||Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS10335 ^@ http://purl.uniprot.org/uniprot/A0A0E3NE08 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/523844:MSTHT_RS09380 ^@ http://purl.uniprot.org/uniprot/A0A0E3N9P6 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type-I 3-dehydroquinase family.|||Homodimer.|||Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS10470 ^@ http://purl.uniprot.org/uniprot/A0A0E3ND05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523844:MSTHT_RS08780 ^@ http://purl.uniprot.org/uniprot/A0A0E3H938 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/523844:MSTHT_RS06505 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPL3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAC-alpha family.|||Contacts the emerging nascent chain on the ribosome.|||Homodimer. Interacts with the ribosome. Binds ribosomal RNA. http://togogenome.org/gene/523844:MSTHT_RS05680 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYQ2 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/523844:MSTHT_RS11405 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEA3 ^@ Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS11100 ^@ http://purl.uniprot.org/uniprot/A0A0E3NA78 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethane group. http://togogenome.org/gene/523844:MSTHT_RS09360 ^@ http://purl.uniprot.org/uniprot/A0A0E3NC91 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/523844:MSTHT_RS13200 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9K2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/523844:MSTHT_RS12510 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQB8 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS01430 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBV4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/523844:MSTHT_RS08755 ^@ http://purl.uniprot.org/uniprot/A0A0E3H937 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrI family.|||Binds 1 zinc ion per subunit.|||Contains catalytic and regulatory chains.|||Involved in allosteric regulation of aspartate carbamoyltransferase. http://togogenome.org/gene/523844:MSTHT_RS10535 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9A2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/523844:MSTHT_RS05620 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8R7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Membrane|||Part of an ABC transporter complex. Responsible for energy coupling to the transport system.|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/523844:MSTHT_RS11555 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAB4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FdhD family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Required for formate dehydrogenase (FDH) activity. http://togogenome.org/gene/523844:MSTHT_RS01210 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBU6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. CofH family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.|||The FO synthase complex consists of two subunits, CofG and CofH. http://togogenome.org/gene/523844:MSTHT_RS06310 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8U3 ^@ Similarity ^@ Belongs to the NAD synthetase family. http://togogenome.org/gene/523844:MSTHT_RS12830 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9I7 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS31 family.|||Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/523844:MSTHT_RS05760 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBU8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. Hel308 subfamily.|||DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.|||Monomer. http://togogenome.org/gene/523844:MSTHT_RS08655 ^@ http://purl.uniprot.org/uniprot/A0A0E3H933 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/523844:MSTHT_RS03275 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8H7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/523844:MSTHT_RS02615 ^@ http://purl.uniprot.org/uniprot/A0A0E3N7P5 ^@ Similarity ^@ Belongs to the methylamine corrinoid protein family. http://togogenome.org/gene/523844:MSTHT_RS12690 ^@ http://purl.uniprot.org/uniprot/A0A0E3NFZ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mer family.|||Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS05290 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPE9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/523844:MSTHT_RS04715 ^@ http://purl.uniprot.org/uniprot/A0A0E3KP99 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6A family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/523844:MSTHT_RS10110 ^@ http://purl.uniprot.org/uniprot/A0A0E3H986 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS01240 ^@ http://purl.uniprot.org/uniprot/A0A0E3N7D6 ^@ Function ^@ Part of a potassium transport system. http://togogenome.org/gene/523844:MSTHT_RS06640 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYT5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS11110 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9C3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrK family.|||Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit.|||Heterotetramer of 2 PyrK and 2 PyrD type B subunits.|||Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). http://togogenome.org/gene/523844:MSTHT_RS04615 ^@ http://purl.uniprot.org/uniprot/A0A0E3N8H4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/523844:MSTHT_RS07920 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS05910 ^@ http://purl.uniprot.org/uniprot/A0A0E3NB83 ^@ Function|||Similarity ^@ Belongs to the HypA/HybF family.|||Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. http://togogenome.org/gene/523844:MSTHT_RS05640 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic CoaD family.|||Cytoplasm|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/523844:MSTHT_RS06040 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBW7 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/523844:MSTHT_RS08605 ^@ http://purl.uniprot.org/uniprot/A0A0E3H931 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUA5 family.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/523844:MSTHT_RS12210 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCZ9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/523844:MSTHT_RS01220 ^@ http://purl.uniprot.org/uniprot/A0A0E3N9Z2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CofC family.|||Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS03715 ^@ http://purl.uniprot.org/uniprot/A0A0E3KP32 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS13485 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAX3 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. http://togogenome.org/gene/523844:MSTHT_RS10695 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9A8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrF family.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/523844:MSTHT_RS03985 ^@ http://purl.uniprot.org/uniprot/A0A0E3N813 ^@ Similarity ^@ Belongs to the ATPase gamma chain family. http://togogenome.org/gene/523844:MSTHT_RS05780 ^@ http://purl.uniprot.org/uniprot/A0A0E3NE94 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/523844:MSTHT_RS02170 ^@ http://purl.uniprot.org/uniprot/A0A0E3NA86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS01230 ^@ http://purl.uniprot.org/uniprot/A0A0E3KNT3 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.|||Binds 1 FAD per subunit.|||Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.|||Reduction reaction proceeds via syn addition of hydrogen for double bonds. http://togogenome.org/gene/523844:MSTHT_RS04810 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYJ3 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Arsenite methyltransferase family. http://togogenome.org/gene/523844:MSTHT_RS05135 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS00620 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCU2 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/523844:MSTHT_RS02475 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAB2 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/523844:MSTHT_RS07600 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEQ7 ^@ Similarity ^@ Belongs to the UPF0292 family. http://togogenome.org/gene/523844:MSTHT_RS04820 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS03135 ^@ http://purl.uniprot.org/uniprot/P40881 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gamma-class carbonic anhydrase family.|||Binds 1 Zn(2+) per subunit, at the subunit interface.|||Homotrimer.|||Reversible hydration of carbon dioxide. Important for growth on acetate (PubMed:8041719). As a probably extracellular enzyme, it may support a H(+)/CH(3)COO(-) symport mechanism and/or conversion of CO(2) to HCO(3)(-), removing excess CO(2) produced by growth on acetate (Probable).|||Secreted http://togogenome.org/gene/523844:MSTHT_RS11220 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9C7 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/523844:MSTHT_RS01560 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8B0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatA/E family.|||Cell membrane|||Forms a complex with TatC.|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. http://togogenome.org/gene/523844:MSTHT_RS09885 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ45 ^@ Similarity ^@ Belongs to the myo-inositol 1-phosphate synthase family. http://togogenome.org/gene/523844:MSTHT_RS09700 ^@ http://purl.uniprot.org/uniprot/A0A0E3H971 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/523844:MSTHT_RS05325 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCU5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Part of the 30S ribosomal subunit.|||With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. http://togogenome.org/gene/523844:MSTHT_RS06335 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8U4 ^@ Cofactor|||Function|||Subunit ^@ Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.|||Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/523844:MSTHT_RS06070 ^@ http://purl.uniprot.org/uniprot/A0A0E3ND12 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/523844:MSTHT_RS07915 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYX9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/523844:MSTHT_RS05565 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8R5 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.|||Cytoplasm|||Heterotetramer of two alpha and two beta chains.|||Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway. http://togogenome.org/gene/523844:MSTHT_RS05340 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/523844:MSTHT_RS10900 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ80 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/523844:MSTHT_RS00690 ^@ http://purl.uniprot.org/uniprot/A0A0E3KXW9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the threonine synthase family. Cysteate synthase subfamily.|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate. http://togogenome.org/gene/523844:MSTHT_RS08275 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPU0 ^@ Similarity ^@ Belongs to the HdrB family. http://togogenome.org/gene/523844:MSTHT_RS07385 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPQ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSL4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. http://togogenome.org/gene/523844:MSTHT_RS02955 ^@ http://purl.uniprot.org/uniprot/A0A0E3KY78 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/523844:MSTHT_RS12060 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS03205 ^@ http://purl.uniprot.org/uniprot/A0A0E3NB54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS08770 ^@ http://purl.uniprot.org/uniprot/A0A0E3NF08 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapB family.|||Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.|||Cytoplasm|||Homotetramer.|||Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. http://togogenome.org/gene/523844:MSTHT_RS12070 ^@ http://purl.uniprot.org/uniprot/A0A0E3NFT8 ^@ Function|||Similarity ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/523844:MSTHT_RS12560 ^@ http://purl.uniprot.org/uniprot/A0A0E3ND28 ^@ Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 2 family. http://togogenome.org/gene/523844:MSTHT_RS08660 ^@ http://purl.uniprot.org/uniprot/A0A0E3N9I7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.|||Cytoplasm|||May catalyze the biosynthesis of dTMP using an unknown cosubstrate.|||Monomer. http://togogenome.org/gene/523844:MSTHT_RS11330 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9D1 ^@ Similarity ^@ Belongs to the methylamine corrinoid protein family. http://togogenome.org/gene/523844:MSTHT_RS13085 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQE6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Belongs to the NnrE/AIBP family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Homotetramer.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS10725 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ74 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/523844:MSTHT_RS05230 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYL7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal phosphopantothenate synthetase family.|||Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS09710 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDT4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS03560 ^@ http://purl.uniprot.org/uniprot/A0A0E3N7X7 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/523844:MSTHT_RS03330 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYA1 ^@ Similarity ^@ Belongs to the PspA/IM30 family. http://togogenome.org/gene/523844:MSTHT_RS11095 ^@ http://purl.uniprot.org/uniprot/A0A0E3ND58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS11235 ^@ http://purl.uniprot.org/uniprot/A0A0E3NE88 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS07790 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYX5 ^@ Domain|||Function|||Similarity ^@ Belongs to the Nre family.|||Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.|||Involved in DNA damage repair. http://togogenome.org/gene/523844:MSTHT_RS01525 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8A9 ^@ Cofactor|||Similarity ^@ Belongs to the PdaD family.|||Binds 1 pyruvoyl group covalently per subunit. http://togogenome.org/gene/523844:MSTHT_RS07935 ^@ http://purl.uniprot.org/uniprot/A0A0E3H905 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/523844:MSTHT_RS03295 ^@ http://purl.uniprot.org/uniprot/A0A0E3KY99 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS12440 ^@ http://purl.uniprot.org/uniprot/A0A0E3ND19 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the Ni-containing carbon monoxide dehydrogenase family.|||Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.|||Binds 7 [4Fe-4S] clusters per heterotetramer.|||Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.|||Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).|||Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. http://togogenome.org/gene/523844:MSTHT_RS05300 ^@ http://purl.uniprot.org/uniprot/A0A0E3N8Q1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Cytoplasm|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/523844:MSTHT_RS11895 ^@ http://purl.uniprot.org/uniprot/A0A0E3NFS5 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HdrE family.|||Binds 2 heme b (iron(II)-protoporphyrin IX) groups per subunit.|||Cell membrane|||Methanophenazine seems to mediate electron transfer from F(420)H(2) dehydrogenase to the dihydromethanophenazine:CoB--CoM heterodisulfide reductase.|||Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrE may be responsible for anchoring the complex to the membrane (PubMed:9654152, PubMed:9665708, PubMed:11034998). Electrons probably transfer from phenazine to the high potential 4Fe cluster in HdrD subunit, then to the low potential heme in HdrE subunit and finally to CoM-S-S-CoB (PubMed:11034998).|||The dihydromethanophenazine:CoB--CoM heterodisulfide reductase is composed of two subunits; HdrD and HdrE. http://togogenome.org/gene/523844:MSTHT_RS11595 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQ70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/523844:MSTHT_RS08390 ^@ http://purl.uniprot.org/uniprot/A0A0E3H923 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/523844:MSTHT_RS12550 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQC0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS02465 ^@ http://purl.uniprot.org/uniprot/A0A0E3NC31 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/523844:MSTHT_RS12435 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZD0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CdhB family.|||Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).|||Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation. http://togogenome.org/gene/523844:MSTHT_RS07785 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8Z9 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/523844:MSTHT_RS09625 ^@ http://purl.uniprot.org/uniprot/A0A0E3H968 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/523844:MSTHT_RS07145 ^@ http://purl.uniprot.org/uniprot/A0A0E3NC72 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobD/CbiB family.|||Cell membrane|||Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS10030 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ50 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.|||Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. http://togogenome.org/gene/523844:MSTHT_RS01900 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBY2 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/523844:MSTHT_RS06045 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYR4 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Part of the 30S ribosomal subunit. Contacts protein S4.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/523844:MSTHT_RS07125 ^@ http://purl.uniprot.org/uniprot/A0A0E3ND89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS02025 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAU1 ^@ Function|||Similarity ^@ Belongs to the ferredoxin thioredoxin reductase beta subunit family.|||Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin. http://togogenome.org/gene/523844:MSTHT_RS08160 ^@ http://purl.uniprot.org/uniprot/A0A0E3N9E5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS07290 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDA1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS06010 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 2 subfamily.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS07585 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCA7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate 5-kinase family.|||Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS08715 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ07 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase IV family.|||Binds 1 Fe(2+) ion per subunit.|||Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS07860 ^@ http://purl.uniprot.org/uniprot/A0A0E3H902 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. UPF0219 family. http://togogenome.org/gene/523844:MSTHT_RS09375 ^@ http://purl.uniprot.org/uniprot/A0A0E3H960 ^@ Function|||Similarity ^@ Belongs to the archaeal-type DHQ synthase family.|||Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis. http://togogenome.org/gene/523844:MSTHT_RS06095 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBX1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges. http://togogenome.org/gene/523844:MSTHT_RS07025 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8X0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.|||Cell membrane|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/523844:MSTHT_RS01730 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8B7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 3 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/523844:MSTHT_RS00770 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBS2 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS12635 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZD7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MntP (TC 9.B.29) family.|||Cell membrane|||Probably functions as a manganese efflux pump. http://togogenome.org/gene/523844:MSTHT_RS03995 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYE1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/523844:MSTHT_RS02845 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDE5 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/523844:MSTHT_RS08735 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDK9 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/523844:MSTHT_RS10905 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCP8 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. http://togogenome.org/gene/523844:MSTHT_RS08115 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEW2 ^@ Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/523844:MSTHT_RS10505 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQ31 ^@ Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. http://togogenome.org/gene/523844:MSTHT_RS06085 ^@ http://purl.uniprot.org/uniprot/A0A0E3NB99 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/523844:MSTHT_RS06415 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPK9 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/523844:MSTHT_RS08720 ^@ http://purl.uniprot.org/uniprot/A0A0E3NF05 ^@ Function ^@ Protects DNA against thermal denaturation and modulates transcription. http://togogenome.org/gene/523844:MSTHT_RS05480 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCV8 ^@ Similarity ^@ Belongs to the phosphate acetyltransferase and butyryltransferase family. http://togogenome.org/gene/523844:MSTHT_RS09760 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPZ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA polymerase delta/II small subunit family.|||Heterodimer of a large subunit and a small subunit.|||Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. http://togogenome.org/gene/523844:MSTHT_RS07970 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDE8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta-RFA-P synthase family.|||Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS06055 ^@ http://purl.uniprot.org/uniprot/A0A0E3N8W1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/523844:MSTHT_RS08155 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYY8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS05685 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCY3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS11020 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9B9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/523844:MSTHT_RS11180 ^@ http://purl.uniprot.org/uniprot/A0A0E3NE83 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) per subunit. http://togogenome.org/gene/523844:MSTHT_RS09295 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPY0 ^@ Similarity ^@ Belongs to the FwdC/FmdC family. http://togogenome.org/gene/523844:MSTHT_RS10775 ^@ http://purl.uniprot.org/uniprot/A0A0E3NE44 ^@ Similarity ^@ Belongs to the aconitase/IPM isomerase family. http://togogenome.org/gene/523844:MSTHT_RS00495 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCT4 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the NifH/BchL/ChlL family.|||Binds 1 [4Fe-4S] cluster per dimer.|||Homodimer.|||The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.|||The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.|||The reversible ADP-ribosylation of Arg-99 inactivates the nitrogenase reductase and regulates nitrogenase activity. http://togogenome.org/gene/523844:MSTHT_RS12355 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQA8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.|||Cell membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. http://togogenome.org/gene/523844:MSTHT_RS12640 ^@ http://purl.uniprot.org/uniprot/A0A0E3NFY9 ^@ Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. http://togogenome.org/gene/523844:MSTHT_RS01710 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAR7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRP4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. http://togogenome.org/gene/523844:MSTHT_RS13050 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQE4 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the MRE11/RAD32 family.|||Binds 2 manganese ions per subunit.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nuclease activity is regulated by Rad50.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. http://togogenome.org/gene/523844:MSTHT_RS01640 ^@ http://purl.uniprot.org/uniprot/A0A0E3KNU6 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/523844:MSTHT_RS04635 ^@ http://purl.uniprot.org/uniprot/A0A0E3KP90 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/523844:MSTHT_RS03165 ^@ http://purl.uniprot.org/uniprot/A0A0E3KY91 ^@ Similarity ^@ Belongs to the UPF0280 family. http://togogenome.org/gene/523844:MSTHT_RS10995 ^@ http://purl.uniprot.org/uniprot/A0A0E3ND49 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.|||Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base.|||Monomer and homodimer. http://togogenome.org/gene/523844:MSTHT_RS10200 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ57 ^@ Similarity ^@ Belongs to the methylamine corrinoid protein family. http://togogenome.org/gene/523844:MSTHT_RS09405 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDR6 ^@ Function|||Similarity ^@ Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.|||Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.|||In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.|||In the N-terminal section; belongs to the formaldehyde-activating enzyme family. http://togogenome.org/gene/523844:MSTHT_RS07660 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPR1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS06140 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYR8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/523844:MSTHT_RS09670 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCB9 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CheB family.|||Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.|||Cytoplasm|||Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.|||Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity. http://togogenome.org/gene/523844:MSTHT_RS12610 ^@ http://purl.uniprot.org/uniprot/A0A0E3ND37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS11050 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ84 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS04495 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8M4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS04515 ^@ http://purl.uniprot.org/uniprot/A0A0E3N8G1 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/523844:MSTHT_RS05015 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBQ1 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/523844:MSTHT_RS11075 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ85 ^@ Similarity ^@ Belongs to the Ahb/Nir family. http://togogenome.org/gene/523844:MSTHT_RS09955 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ48 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.|||Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).|||Homotetramer. Interacts with SepCysS. http://togogenome.org/gene/523844:MSTHT_RS08380 ^@ http://purl.uniprot.org/uniprot/A0A0E3N9G3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS06615 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEH0 ^@ Similarity ^@ Belongs to the Mg-chelatase subunit H family. http://togogenome.org/gene/523844:MSTHT_RS03965 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS06060 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPJ1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/523844:MSTHT_RS04450 ^@ http://purl.uniprot.org/uniprot/A0A0E3KP69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS10115 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDY7 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/523844:MSTHT_RS01540 ^@ http://purl.uniprot.org/uniprot/A0A0E3NA21 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Forms a complex with TatA.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/523844:MSTHT_RS10680 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCM5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrC family.|||Cell membrane|||Membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/523844:MSTHT_RS06760 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8W0 ^@ Similarity ^@ Belongs to the archaeal-type GPI family. http://togogenome.org/gene/523844:MSTHT_RS01715 ^@ http://purl.uniprot.org/uniprot/A0A0E3N7G9 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/523844:MSTHT_RS11900 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEE1 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the HdrD family.|||Binds 2 [4Fe-4S] cluster.|||Methanophenazine seems to mediate electron transfer from F(420)H(2) dehydrogenase to the dihydromethanophenazine:CoB--CoM heterodisulfide reductase.|||Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B) (PubMed:9654152, PubMed:9665708, PubMed:11034998). Electrons probably transfer from phenazine to the high potential 4Fe cluster in HdrD subunit, then to the low potential heme in HdrE subunit and finally to CoM-S-S-CoB (PubMed:11034998).|||The dihydromethanophenazine:CoB--CoM heterodisulfide reductase is composed of two subunits; HdrD and HdrE. http://togogenome.org/gene/523844:MSTHT_RS10355 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCZ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS04470 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8M3 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/523844:MSTHT_RS13015 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEN1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.|||Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.|||Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS02050 ^@ http://purl.uniprot.org/uniprot/A0A0E3KNW0 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the GatB/GatE family. GatE subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/523844:MSTHT_RS12320 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9G7 ^@ Similarity ^@ Belongs to the UPF0284 family. http://togogenome.org/gene/523844:MSTHT_RS08185 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYY9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS00890 ^@ http://purl.uniprot.org/uniprot/A0A0E3KNS3 ^@ Function|||Similarity ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.|||Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. http://togogenome.org/gene/523844:MSTHT_RS08690 ^@ http://purl.uniprot.org/uniprot/A0A0E3NC27 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/523844:MSTHT_RS04130 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAR9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/523844:MSTHT_RS05335 ^@ http://purl.uniprot.org/uniprot/A0A0E3NB36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS00635 ^@ http://purl.uniprot.org/uniprot/A0A0E3KNR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-archaeol synthase family.|||Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.|||Cell membrane http://togogenome.org/gene/523844:MSTHT_RS11710 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZA6 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/523844:MSTHT_RS13315 ^@ http://purl.uniprot.org/uniprot/A0A0E3NG52 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/523844:MSTHT_RS11785 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQ77 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.|||Monomer.|||The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity. http://togogenome.org/gene/523844:MSTHT_RS00615 ^@ http://purl.uniprot.org/uniprot/A0A0E3H875 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS11770 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZA9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase small subunit family.|||Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/523844:MSTHT_RS03455 ^@ http://purl.uniprot.org/uniprot/A0A0E3KP20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LPG synthase family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS03410 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8I2 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/523844:MSTHT_RS02090 ^@ http://purl.uniprot.org/uniprot/A0A0E3N7J6 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS00295 ^@ http://purl.uniprot.org/uniprot/A0A0E3KNQ7 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the THI4 family.|||Homooctamer; tetramer of dimers.|||Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS07050 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPN8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NadC/ModD family.|||Hexamer formed by 3 homodimers.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/523844:MSTHT_RS00875 ^@ http://purl.uniprot.org/uniprot/A0A0E3H884 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS06690 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBE0 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/523844:MSTHT_RS06445 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPL1 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/523844:MSTHT_RS11495 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAA9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta-RFA-P synthase family.|||Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS09365 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPY3 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/523844:MSTHT_RS08125 ^@ http://purl.uniprot.org/uniprot/A0A0E3H913 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GGGP/HepGP synthase family. Group II subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/523844:MSTHT_RS08685 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ06 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/523844:MSTHT_RS01055 ^@ http://purl.uniprot.org/uniprot/A0A0E3N9X8 ^@ Function|||Similarity ^@ Belongs to the PEP-utilizing enzyme family.|||Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. http://togogenome.org/gene/523844:MSTHT_RS12245 ^@ http://purl.uniprot.org/uniprot/A0A0E3NFV4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS06635 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBD7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS10715 ^@ http://purl.uniprot.org/uniprot/A0A0E3NE39 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Monomer. http://togogenome.org/gene/523844:MSTHT_RS01005 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAN2 ^@ Cofactor|||Function|||Subunit ^@ Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.|||Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/523844:MSTHT_RS11045 ^@ http://purl.uniprot.org/uniprot/A0A0E3ND54 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DHBP synthase family.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS05925 ^@ http://purl.uniprot.org/uniprot/A0A0E3N8V5 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/523844:MSTHT_RS11345 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ94 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/523844:MSTHT_RS06075 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8T4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/523844:MSTHT_RS05255 ^@ http://purl.uniprot.org/uniprot/A0A0E3NE41 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. http://togogenome.org/gene/523844:MSTHT_RS02810 ^@ http://purl.uniprot.org/uniprot/A0A0E3KY70 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS06050 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8T3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/523844:MSTHT_RS11490 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQ66 ^@ Similarity ^@ Belongs to the NOP5/NOP56 family. http://togogenome.org/gene/523844:MSTHT_RS02715 ^@ http://purl.uniprot.org/uniprot/A0A0E3KY62 ^@ Function|||Similarity|||Subunit ^@ Belongs to the anthranilate synthase component I family.|||Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).|||Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. http://togogenome.org/gene/523844:MSTHT_RS01145 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCY2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS04160 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS11470 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS09510 ^@ http://purl.uniprot.org/uniprot/A0A0E3H964 ^@ Similarity ^@ Belongs to the archaeosine synthase type 1 family. http://togogenome.org/gene/523844:MSTHT_RS04000 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDR8 ^@ Function|||Similarity ^@ Belongs to the archaeal 6-HMPDK family.|||Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP). http://togogenome.org/gene/523844:MSTHT_RS05920 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBW2 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/523844:MSTHT_RS00630 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBR6 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS10570 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9A3 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP phosphoribosyltransferase family. Long subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Feedback inhibited by histidine. http://togogenome.org/gene/523844:MSTHT_RS10400 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRISPR system Cmr5 family.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS08615 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEZ7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal DNA polymerase II family.|||Heterodimer of a large subunit and a small subunit.|||Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. http://togogenome.org/gene/523844:MSTHT_RS04070 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8K7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).|||Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS04075 ^@ http://purl.uniprot.org/uniprot/A0A0E3KP46 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose 5-phosphate isomerase family.|||Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS00860 ^@ http://purl.uniprot.org/uniprot/A0A0E3KNS2 ^@ Caution|||Function|||Similarity ^@ Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.|||Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS07505 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYW5 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/523844:MSTHT_RS09385 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ29 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the shikimate dehydrogenase family.|||Homodimer.|||Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS02270 ^@ http://purl.uniprot.org/uniprot/A0A0E3NC15 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/523844:MSTHT_RS06025 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8T2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.|||Cytoplasm|||Monomer. http://togogenome.org/gene/523844:MSTHT_RS10690 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ73 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrA family.|||Binds 1 5-hydroxybenzimidazolylcobamide group.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/523844:MSTHT_RS02095 ^@ http://purl.uniprot.org/uniprot/A0A0E3ND69 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS02030 ^@ http://purl.uniprot.org/uniprot/A0A0E3N7I8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HdrA family.|||Cytoplasm|||Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).|||The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC. http://togogenome.org/gene/523844:MSTHT_RS05795 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCZ2 ^@ Similarity ^@ Belongs to the snRNP Sm proteins family. http://togogenome.org/gene/523844:MSTHT_RS08775 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ09 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/523844:MSTHT_RS04045 ^@ http://purl.uniprot.org/uniprot/A0A0E3KP44 ^@ Similarity ^@ Belongs to the UPF0210 family. http://togogenome.org/gene/523844:MSTHT_RS13445 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9L1 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/523844:MSTHT_RS11440 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAA3 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.|||Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction proceeds via a cis-phosphoenolate intermediate. http://togogenome.org/gene/523844:MSTHT_RS06115 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEC5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/523844:MSTHT_RS07130 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8X4 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/523844:MSTHT_RS09030 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCL0 ^@ Similarity ^@ Belongs to the HisA/HisF family. http://togogenome.org/gene/523844:MSTHT_RS12040 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCY4 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/523844:MSTHT_RS01855 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8C2 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.|||Cytoplasm|||Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.|||In Archaea the pyridoxal phosphate cofactor is not covalently bound to Lys but ligated by other amino acids.|||Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. http://togogenome.org/gene/523844:MSTHT_RS10070 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCH2 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. http://togogenome.org/gene/523844:MSTHT_RS02645 ^@ http://purl.uniprot.org/uniprot/A0A0E3KY58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS07415 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPQ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CofD family.|||Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS10185 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCY1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS09040 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ18 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/523844:MSTHT_RS08270 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCE9 ^@ Similarity ^@ Belongs to the HdrC family. http://togogenome.org/gene/523844:MSTHT_RS07075 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBG2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS09055 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPX1 ^@ Function|||Similarity ^@ Belongs to the MTD family.|||Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. http://togogenome.org/gene/523844:MSTHT_RS02410 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8E4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS10780 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCN7 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/523844:MSTHT_RS07080 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8X2 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/523844:MSTHT_RS08580 ^@ http://purl.uniprot.org/uniprot/A0A0E3H930 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/523844:MSTHT_RS12080 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9F9 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. http://togogenome.org/gene/523844:MSTHT_RS11070 ^@ http://purl.uniprot.org/uniprot/A0A0E3NE72 ^@ Similarity ^@ Belongs to the Ahb/Nir family. http://togogenome.org/gene/523844:MSTHT_RS11105 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ86 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS06170 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYR9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.|||Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS07965 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYY2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family.|||Binds 2 manganese ions per subunit.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/523844:MSTHT_RS13415 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQH3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/523844:MSTHT_RS06995 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEK7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the OMP decarboxylase family. Type 1 subfamily.|||Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS11125 ^@ http://purl.uniprot.org/uniprot/A0A0E3NE76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS07015 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPN7 ^@ Function|||Similarity ^@ Belongs to the HARP family.|||RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. http://togogenome.org/gene/523844:MSTHT_RS02065 ^@ http://purl.uniprot.org/uniprot/A0A0E3NA77 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/523844:MSTHT_RS05020 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPD4 ^@ Similarity ^@ Belongs to the UPF0228 family. http://togogenome.org/gene/523844:MSTHT_RS05000 ^@ http://purl.uniprot.org/uniprot/A0A0E3NB16 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/523844:MSTHT_RS11305 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9D0 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/523844:MSTHT_RS12240 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQA2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS08120 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYY7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL40 family. http://togogenome.org/gene/523844:MSTHT_RS01720 ^@ http://purl.uniprot.org/uniprot/A0A0E3KY18 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/523844:MSTHT_RS07155 ^@ http://purl.uniprot.org/uniprot/A0A0E3N944 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Cell membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS07640 ^@ http://purl.uniprot.org/uniprot/A0A0E3N997 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.|||Cell membrane|||Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Membrane|||Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function. http://togogenome.org/gene/523844:MSTHT_RS05690 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.|||Belongs to the TiaS family.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS08455 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDI2 ^@ Caution|||Function|||Similarity ^@ Belongs to the TBP family.|||General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS09895 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCF9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC61-beta family.|||Cell membrane|||Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.|||Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS00420 ^@ http://purl.uniprot.org/uniprot/A0A0E3H869 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS01550 ^@ http://purl.uniprot.org/uniprot/A0A0E3KNU3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Forms a complex with TatA.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/523844:MSTHT_RS07945 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS08065 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Cytoplasm|||Functions by promoting the formation of the first peptide bond. http://togogenome.org/gene/523844:MSTHT_RS03255 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAI1 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/523844:MSTHT_RS12380 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEH5 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/523844:MSTHT_RS01075 ^@ http://purl.uniprot.org/uniprot/A0A0E3N7C2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS07680 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8Z5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS02960 ^@ http://purl.uniprot.org/uniprot/A0A0E3N7S4 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/523844:MSTHT_RS05520 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8R3 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/523844:MSTHT_RS02990 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAG3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/523844:MSTHT_RS00250 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBP7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS01950 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBY7 ^@ Similarity|||Subunit ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Homohexamer. http://togogenome.org/gene/523844:MSTHT_RS01290 ^@ http://purl.uniprot.org/uniprot/A0A0E3KNT5 ^@ Function|||Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family.|||Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. http://togogenome.org/gene/523844:MSTHT_RS12505 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDE9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/523844:MSTHT_RS06405 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBC0 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/523844:MSTHT_RS03310 ^@ http://purl.uniprot.org/uniprot/A0A0E3KP15 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. http://togogenome.org/gene/523844:MSTHT_RS09945 ^@ http://purl.uniprot.org/uniprot/A0A0E3H980 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/523844:MSTHT_RS09425 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS10945 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ81 ^@ Similarity ^@ Belongs to the methylamine corrinoid protein family. http://togogenome.org/gene/523844:MSTHT_RS10140 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQ18 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the CofE family.|||Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.|||Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.|||Homodimer.|||Monovalent cation. The ion could be potassium. http://togogenome.org/gene/523844:MSTHT_RS02210 ^@ http://purl.uniprot.org/uniprot/A0A0E3NC13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS08515 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ00 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/523844:MSTHT_RS12700 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal NMN adenylyltransferase family.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS04355 ^@ http://purl.uniprot.org/uniprot/A0A0E3KP63 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PurS family.|||Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/523844:MSTHT_RS00980 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCX0 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MobA family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.|||Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. http://togogenome.org/gene/523844:MSTHT_RS01040 ^@ http://purl.uniprot.org/uniprot/A0A0E3H890 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS08060 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYY5 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/523844:MSTHT_RS04840 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS10065 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ51 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. http://togogenome.org/gene/523844:MSTHT_RS06110 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYR6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/523844:MSTHT_RS06345 ^@ http://purl.uniprot.org/uniprot/A0A0E3ND36 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/523844:MSTHT_RS09830 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQ01 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS05435 ^@ http://purl.uniprot.org/uniprot/A0A0E3NB44 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAK/KUP transporter (TC 2.A.72) family.|||Cell membrane|||Membrane|||Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter. http://togogenome.org/gene/523844:MSTHT_RS13365 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDL9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HdrA family.|||Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).|||The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC. http://togogenome.org/gene/523844:MSTHT_RS12400 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDE3 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the TFE family.|||Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.|||The winged helix domain is involved in binding to DNA in the preinitiation complex.|||Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes. http://togogenome.org/gene/523844:MSTHT_RS10540 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQ32 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/523844:MSTHT_RS09775 ^@ http://purl.uniprot.org/uniprot/A0A0E3H974 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS07925 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPS1 ^@ Similarity ^@ Belongs to the PurH family. http://togogenome.org/gene/523844:MSTHT_RS08520 ^@ http://purl.uniprot.org/uniprot/A0A0E3H928 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS01020 ^@ http://purl.uniprot.org/uniprot/A0A0E3KXY2 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/523844:MSTHT_RS09835 ^@ http://purl.uniprot.org/uniprot/A0A0E3H976 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523844:MSTHT_RS07555 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8Z0 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/523844:MSTHT_RS04680 ^@ http://purl.uniprot.org/uniprot/A0A0E3N8I1 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/523844:MSTHT_RS01215 ^@ http://purl.uniprot.org/uniprot/A0A0E3KXZ1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. CofH family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.|||The FO synthase complex consists of two subunits, CofG and CofH. http://togogenome.org/gene/523844:MSTHT_RS07535 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYW6 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL20 family.|||Part of the 50S ribosomal subunit. Binds 23S rRNA. http://togogenome.org/gene/523844:MSTHT_RS06135 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBA3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29. http://togogenome.org/gene/523844:MSTHT_RS10645 ^@ http://purl.uniprot.org/uniprot/A0A0E3NA41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ModE family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS12820 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZE3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. BUD32 family.|||Binds 1 Fe(2+) ion per subunit.|||Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.|||Cytoplasm|||In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.|||In the N-terminal section; belongs to the KAE1 / TsaD family.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. http://togogenome.org/gene/523844:MSTHT_RS10165 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDZ4 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. RfcS subfamily. http://togogenome.org/gene/523844:MSTHT_RS08130 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDF7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS06165 ^@ http://purl.uniprot.org/uniprot/A0A0E3NED1 ^@ Similarity ^@ Belongs to the archaeal-type GPI family. http://togogenome.org/gene/523844:MSTHT_RS09980 ^@ http://purl.uniprot.org/uniprot/A0A0E3N9X7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS10330 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ61 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/523844:MSTHT_RS10485 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9A0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS06015 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYR3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS09750 ^@ http://purl.uniprot.org/uniprot/A0A0E3H973 ^@ Function ^@ Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/523844:MSTHT_RS06065 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEB9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/523844:MSTHT_RS01415 ^@ http://purl.uniprot.org/uniprot/A0A0E3KY02 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/523844:MSTHT_RS04490 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAV7 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/523844:MSTHT_RS01625 ^@ http://purl.uniprot.org/uniprot/A0A0E3N7G1 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. NudC subfamily. http://togogenome.org/gene/523844:MSTHT_RS11250 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCS5 ^@ Similarity ^@ Belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/523844:MSTHT_RS04015 ^@ http://purl.uniprot.org/uniprot/A0A0E3KP43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FdhD family.|||Cytoplasm|||Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. http://togogenome.org/gene/523844:MSTHT_RS07275 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYV7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS10060 ^@ http://purl.uniprot.org/uniprot/A0A0E3H984 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal dihydroneopterin aldolase family.|||Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).|||Homotetramer. http://togogenome.org/gene/523844:MSTHT_RS05840 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYQ7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/523844:MSTHT_RS07590 ^@ http://purl.uniprot.org/uniprot/A0A0E3N992 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyl phosphate reductase family.|||Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS10515 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCL2 ^@ Caution|||Function|||Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS06030 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPI9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/523844:MSTHT_RS03790 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYD0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS13535 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9L4 ^@ Function|||Similarity ^@ Belongs to the deoxyhypusine synthase family.|||Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. http://togogenome.org/gene/523844:MSTHT_RS01865 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAS9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the quinolinate synthase family. Type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS08445 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEY8 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ThiC family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS03615 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYC1 ^@ Similarity ^@ Belongs to the UPF0237 family. http://togogenome.org/gene/523844:MSTHT_RS08645 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCI2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the methyl-coenzyme M reductase alpha subunit family.|||Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.|||Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.|||Hexamer of two alpha, two beta, and two gamma chains.|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers. http://togogenome.org/gene/523844:MSTHT_RS09545 ^@ http://purl.uniprot.org/uniprot/A0A0E3H965 ^@ Function|||Similarity ^@ Belongs to the KptA/TPT1 family.|||Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase. http://togogenome.org/gene/523844:MSTHT_RS03710 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBC9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS08935 ^@ http://purl.uniprot.org/uniprot/A0A0E3N9L4 ^@ Similarity ^@ Belongs to the UDPGP type 2 family. http://togogenome.org/gene/523844:MSTHT_RS07070 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS05865 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBW0 ^@ Similarity ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. http://togogenome.org/gene/523844:MSTHT_RS06145 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBX3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e. http://togogenome.org/gene/523844:MSTHT_RS06540 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYT2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/523844:MSTHT_RS08575 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDJ4 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/523844:MSTHT_RS12500 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZD2 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/523844:MSTHT_RS10120 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCH8 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/523844:MSTHT_RS06435 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8U8 ^@ Similarity ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/523844:MSTHT_RS12845 ^@ http://purl.uniprot.org/uniprot/A0A0E3NG14 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Spt4 family.|||Heterodimer composed of Spt4 and Spt5.|||Stimulates transcription elongation. http://togogenome.org/gene/523844:MSTHT_RS05205 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.|||Cytoplasm|||Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. http://togogenome.org/gene/523844:MSTHT_RS04630 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDZ0 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. http://togogenome.org/gene/523844:MSTHT_RS12495 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9H4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family.|||Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS01445 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAQ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS05900 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYQ9 ^@ Similarity ^@ Belongs to the HupF/HypC family. http://togogenome.org/gene/523844:MSTHT_RS03630 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDN1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS03900 ^@ http://purl.uniprot.org/uniprot/A0A0E3KP39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523844:MSTHT_RS01060 ^@ http://purl.uniprot.org/uniprot/A0A0E3KNS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.|||Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS03155 ^@ http://purl.uniprot.org/uniprot/A0A0E3NB40 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/523844:MSTHT_RS10005 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDX6 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS00895 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAM4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aTrm56 family.|||Cytoplasm|||Homodimer.|||Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs. http://togogenome.org/gene/523844:MSTHT_RS04700 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCQ2 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/523844:MSTHT_RS11200 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCS1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/523844:MSTHT_RS09715 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS12360 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAK5 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.|||Cell membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Requires K(+) for maximal activity.|||Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane. http://togogenome.org/gene/523844:MSTHT_RS04545 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8M6 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/523844:MSTHT_RS01875 ^@ http://purl.uniprot.org/uniprot/A0A0E3KY25 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. MetX family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. http://togogenome.org/gene/523844:MSTHT_RS00400 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAJ4 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.|||Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS02060 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8D0 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/523844:MSTHT_RS12100 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQ94 ^@ Similarity ^@ Belongs to the carbamoyltransferase HypF family. http://togogenome.org/gene/523844:MSTHT_RS07905 ^@ http://purl.uniprot.org/uniprot/A0A0E3N9C2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS10160 ^@ http://purl.uniprot.org/uniprot/A0A0E3H988 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Cell membrane|||Involved in protein export.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the protein translocation apparatus. Forms a complex with SecF. http://togogenome.org/gene/523844:MSTHT_RS08405 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDI0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/523844:MSTHT_RS04120 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8K9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. UvrA family.|||Cell membrane|||Cytoplasm|||Forms a heterotetramer with UvrB during the search for lesions.|||Membrane|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. http://togogenome.org/gene/523844:MSTHT_RS11695 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCV6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/523844:MSTHT_RS04720 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAY9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6B family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/523844:MSTHT_RS03195 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8H4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Mediates influx of magnesium ions.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS06125 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8T6 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/523844:MSTHT_RS13070 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZF2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS00135 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCQ4 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/523844:MSTHT_RS07060 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CetZ family.|||Cytoplasm|||Involved in cell shape control. http://togogenome.org/gene/523844:MSTHT_RS01740 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBX2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/523844:MSTHT_RS11875 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAF1 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/523844:MSTHT_RS04475 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDX1 ^@ Similarity ^@ Belongs to the UPF0212 family. http://togogenome.org/gene/523844:MSTHT_RS10980 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCQ3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS04350 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBL3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/523844:MSTHT_RS02415 ^@ http://purl.uniprot.org/uniprot/A0A0E3KY46 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS04125 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYE8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrC family.|||Cytoplasm|||Interacts with UvrB in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. http://togogenome.org/gene/523844:MSTHT_RS11880 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9F2 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/523844:MSTHT_RS03550 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8I7 ^@ Caution|||Function|||Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS09530 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPY7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS11260 ^@ http://purl.uniprot.org/uniprot/A0A0E3ND68 ^@ Function|||Similarity ^@ Belongs to the TFIIB family.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/523844:MSTHT_RS05485 ^@ http://purl.uniprot.org/uniprot/A0A0E3NB50 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Cytoplasm|||Homodimer.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/523844:MSTHT_RS11430 ^@ http://purl.uniprot.org/uniprot/A0A0E3ND81 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS07545 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPQ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/523844:MSTHT_RS06080 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYR5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/523844:MSTHT_RS12180 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAJ1 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/523844:MSTHT_RS01810 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8C0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the thiamine-phosphate synthase family.|||Binds 1 Mg(2+) ion per subunit.|||Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). http://togogenome.org/gene/523844:MSTHT_RS12900 ^@ http://purl.uniprot.org/uniprot/A0A0E3NG20 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/523844:MSTHT_RS02380 ^@ http://purl.uniprot.org/uniprot/A0A0E3NC23 ^@ Cofactor|||Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/523844:MSTHT_RS03145 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAH1 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/523844:MSTHT_RS10155 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ56 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecF subfamily.|||Cell membrane|||Involved in protein export.|||Membrane|||Part of the protein translocation apparatus. Forms a complex with SecD. http://togogenome.org/gene/523844:MSTHT_RS05800 ^@ http://purl.uniprot.org/uniprot/A0A0E3NB74 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/523844:MSTHT_RS11985 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9F6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/523844:MSTHT_RS03800 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8J7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS10235 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS06685 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPM0 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/523844:MSTHT_RS03980 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBH5 ^@ Similarity ^@ Belongs to the ATPase alpha/beta chains family. http://togogenome.org/gene/523844:MSTHT_RS04330 ^@ http://purl.uniprot.org/uniprot/A0A0E3KP61 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/523844:MSTHT_RS15170 ^@ http://purl.uniprot.org/uniprot/A0A0E3NC05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS02345 ^@ http://purl.uniprot.org/uniprot/A0A0E3KNX1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCH family.|||Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS01185 ^@ http://purl.uniprot.org/uniprot/A0A0E3KXZ0 ^@ Similarity ^@ Belongs to the complex I 20 kDa subunit family. http://togogenome.org/gene/523844:MSTHT_RS09370 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCN6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.|||Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.|||Homodecamer. http://togogenome.org/gene/523844:MSTHT_RS08600 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPV4 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.|||Belongs to the RuBisCO large chain family. Type III subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.|||Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits. http://togogenome.org/gene/523844:MSTHT_RS11825 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal histone HMF family.|||Chromosome|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS09085 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCL4 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/523844:MSTHT_RS11800 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9E9 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/523844:MSTHT_RS08205 ^@ http://purl.uniprot.org/uniprot/A0A0E3H916 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS06105 ^@ http://purl.uniprot.org/uniprot/A0A0E3N8W5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/523844:MSTHT_RS12835 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQD5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/523844:MSTHT_RS01795 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBX5 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/523844:MSTHT_RS07960 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEU9 ^@ Similarity ^@ Belongs to the gamma-class carbonic anhydrase family. http://togogenome.org/gene/523844:MSTHT_RS08635 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPV6 ^@ Subunit ^@ MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known. http://togogenome.org/gene/523844:MSTHT_RS11690 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQ73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/523844:MSTHT_RS05145 ^@ http://purl.uniprot.org/uniprot/A0A0E3NE31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS12615 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS08545 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCH3 ^@ Function|||Similarity ^@ Acts on leucine, isoleucine and valine.|||Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/523844:MSTHT_RS04235 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCH9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SepCysS family.|||Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).|||Homodimer. Interacts with SepRS. http://togogenome.org/gene/523844:MSTHT_RS09645 ^@ http://purl.uniprot.org/uniprot/A0A0E3NF71 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FTR family.|||Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/523844:MSTHT_RS02740 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDB5 ^@ Similarity ^@ Belongs to the TrpC family. http://togogenome.org/gene/523844:MSTHT_RS08435 ^@ http://purl.uniprot.org/uniprot/A0A0E3N9G7 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGMT family.|||Cytoplasm|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.|||This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles. http://togogenome.org/gene/523844:MSTHT_RS11230 ^@ http://purl.uniprot.org/uniprot/A0A0E3NFL4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the isopentenyl phosphate kinase family.|||Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS03945 ^@ http://purl.uniprot.org/uniprot/A0A0E3KP40 ^@ Similarity ^@ Belongs to the ATPase alpha/beta chains family. http://togogenome.org/gene/523844:MSTHT_RS12990 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQE1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CbiX family. CbiXS subfamily.|||Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.|||Homotetramer; dimer of dimers. http://togogenome.org/gene/523844:MSTHT_RS11795 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCW5 ^@ Function|||Similarity ^@ Belongs to the adenylate cyclase family. DacZ subfamily.|||Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. http://togogenome.org/gene/523844:MSTHT_RS13495 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZL2 ^@ Similarity ^@ In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/523844:MSTHT_RS05295 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBR7 ^@ Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Part of the RNA polymerase complex. http://togogenome.org/gene/523844:MSTHT_RS04405 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA-PH family.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS05710 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYQ3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS10495 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ67 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS08470 ^@ http://purl.uniprot.org/uniprot/A0A0E3NC00 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/523844:MSTHT_RS10480 ^@ http://purl.uniprot.org/uniprot/A0A0E3NA24 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS05140 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8P8 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the asparaginase 1 family. GatD subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/523844:MSTHT_RS09400 ^@ http://purl.uniprot.org/uniprot/A0A0E3H961 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homotetramer; dimer of dimers.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/523844:MSTHT_RS05805 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8S4 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/523844:MSTHT_RS07265 ^@ http://purl.uniprot.org/uniprot/A0A0E3N956 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S16 family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS10675 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQ37 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrD family.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/523844:MSTHT_RS12295 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZC5 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/523844:MSTHT_RS09110 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ20 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/523844:MSTHT_RS09940 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDX3 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/523844:MSTHT_RS02795 ^@ http://purl.uniprot.org/uniprot/A0A0E3KNZ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS06330 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEE5 ^@ Function|||Subunit ^@ Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/523844:MSTHT_RS11225 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQ56 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS07400 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8Y4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.|||Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS04550 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAW3 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. http://togogenome.org/gene/523844:MSTHT_RS03575 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8I8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS10565 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ69 ^@ Function|||Similarity ^@ Belongs to the AdoMet synthase 2 family.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/523844:MSTHT_RS10685 ^@ http://purl.uniprot.org/uniprot/A0A0E3ND30 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrB family.|||Cell membrane|||Membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/523844:MSTHT_RS11355 ^@ http://purl.uniprot.org/uniprot/A0A0E3NE97 ^@ Cofactor|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein. http://togogenome.org/gene/523844:MSTHT_RS06780 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPM9 ^@ Similarity ^@ Belongs to the tRNA(His) guanylyltransferase family. http://togogenome.org/gene/523844:MSTHT_RS06770 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYU0 ^@ Function|||Similarity ^@ Belongs to the LDH/MDH superfamily.|||Catalyzes the reversible oxidation of malate to oxaloacetate. http://togogenome.org/gene/523844:MSTHT_RS07780 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBP1 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/523844:MSTHT_RS02590 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8F1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS13190 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZG1 ^@ Similarity ^@ In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.|||In the central section; belongs to the CRISPR-associated helicase Cas3 family. http://togogenome.org/gene/523844:MSTHT_RS09325 ^@ http://purl.uniprot.org/uniprot/A0A0E3N9P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CitM (TC 2.A.11) transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS09535 ^@ http://purl.uniprot.org/uniprot/A0A0E3NF64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS08665 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPV7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS08290 ^@ http://purl.uniprot.org/uniprot/A0A0E3H919 ^@ Similarity ^@ Belongs to the UPF0251 family. http://togogenome.org/gene/523844:MSTHT_RS00755 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCV1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Ni-containing carbon monoxide dehydrogenase family.|||CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS08725 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. ArgB subfamily.|||Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS05610 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYP8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CbiN family.|||Cell membrane|||Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.|||Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. http://togogenome.org/gene/523844:MSTHT_RS12200 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEG5 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/523844:MSTHT_RS02315 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8E0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS13010 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZF0 ^@ Domain|||Function|||Miscellaneous|||Similarity ^@ Belongs to the CobB/CbiA family.|||Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.|||Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.|||The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate. http://togogenome.org/gene/523844:MSTHT_RS07605 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8Z2 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/523844:MSTHT_RS05615 ^@ http://purl.uniprot.org/uniprot/A0A0E3NE79 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS07380 ^@ http://purl.uniprot.org/uniprot/A0A0E3N969 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/523844:MSTHT_RS06590 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPL6 ^@ Similarity ^@ Belongs to the Mg-chelatase subunits D/I family. http://togogenome.org/gene/523844:MSTHT_RS08340 ^@ http://purl.uniprot.org/uniprot/A0A0E3H921 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.|||Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. http://togogenome.org/gene/523844:MSTHT_RS05510 ^@ http://purl.uniprot.org/uniprot/A0A0E3NE68 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/523844:MSTHT_RS03400 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYA5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PEPCase type 2 family.|||Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.|||Homotetramer. http://togogenome.org/gene/523844:MSTHT_RS12850 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZE4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.|||Nucleus|||Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure. http://togogenome.org/gene/523844:MSTHT_RS08375 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCF8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/523844:MSTHT_RS10015 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQ11 ^@ Domain|||Function|||Miscellaneous|||Similarity ^@ Belongs to the CobB/CbiA family.|||Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.|||Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.|||The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate. http://togogenome.org/gene/523844:MSTHT_RS05825 ^@ http://purl.uniprot.org/uniprot/A0A0E3N8U9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS01665 ^@ http://purl.uniprot.org/uniprot/A0A0E3KY16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS13455 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDA0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase Z family.|||Binds 2 Zn(2+) ions.|||Homodimer.|||Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. http://togogenome.org/gene/523844:MSTHT_RS13110 ^@ http://purl.uniprot.org/uniprot/A0A0E3NG34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS04610 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBN2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Cytoplasm|||Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.|||Part of the 50S ribosomal subunit. Probably part of the RNase P complex. http://togogenome.org/gene/523844:MSTHT_RS12195 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9G3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the QueC family.|||Binds 1 zinc ion per subunit.|||Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). http://togogenome.org/gene/523844:MSTHT_RS05755 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPH3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS03640 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCC8 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/523844:MSTHT_RS05345 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBS1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/523844:MSTHT_RS08220 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYZ0 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/523844:MSTHT_RS04705 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8N2 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/523844:MSTHT_RS04460 ^@ http://purl.uniprot.org/uniprot/A0A0E3N8F6 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/523844:MSTHT_RS09650 ^@ http://purl.uniprot.org/uniprot/A0A0E3H969 ^@ Function|||Similarity ^@ Belongs to the CheD family.|||Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis. http://togogenome.org/gene/523844:MSTHT_RS06570 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYT3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/523844:MSTHT_RS10800 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9B2 ^@ Similarity ^@ Belongs to the UPF0107 family. http://togogenome.org/gene/523844:MSTHT_RS07205 ^@ http://purl.uniprot.org/uniprot/A0A0E3NC77 ^@ Similarity ^@ Belongs to the methylamine corrinoid protein family. http://togogenome.org/gene/523844:MSTHT_RS01150 ^@ http://purl.uniprot.org/uniprot/A0A0E3H894 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS10895 ^@ http://purl.uniprot.org/uniprot/A0A0E3NE56 ^@ Function|||Similarity ^@ Belongs to the CbiD family.|||Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. http://togogenome.org/gene/523844:MSTHT_RS03055 ^@ http://purl.uniprot.org/uniprot/A0A0E3NB23 ^@ Similarity ^@ Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/523844:MSTHT_RS12075 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEF6 ^@ Function|||Similarity ^@ Belongs to the V-ATPase F subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/523844:MSTHT_RS06585 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBD2 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/523844:MSTHT_RS02600 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAX8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS08400 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPU7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/523844:MSTHT_RS10700 ^@ http://purl.uniprot.org/uniprot/A0A0E3NA48 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrG family.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/523844:MSTHT_RS07480 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8Y7 ^@ Similarity ^@ Belongs to the FrhG family. http://togogenome.org/gene/523844:MSTHT_RS06630 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8V5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS11455 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQ65 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/523844:MSTHT_RS06130 ^@ http://purl.uniprot.org/uniprot/A0A0E3ND17 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/523844:MSTHT_RS04485 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCN0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the diphthine synthase family.|||Homodimer.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/523844:MSTHT_RS00145 ^@ http://purl.uniprot.org/uniprot/A0A0E3H859 ^@ Similarity ^@ Belongs to the DMRL synthase family. http://togogenome.org/gene/523844:MSTHT_RS06120 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPJ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/523844:MSTHT_RS01805 ^@ http://purl.uniprot.org/uniprot/A0A0E3NA47 ^@ Function|||Similarity ^@ Belongs to the Thz kinase family.|||Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ). http://togogenome.org/gene/523844:MSTHT_RS13160 ^@ http://purl.uniprot.org/uniprot/A0A0E3NG39 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the WrbA family.|||Binds 1 FMN per monomer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS08005 ^@ http://purl.uniprot.org/uniprot/A0A0E3N9D1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS00075 ^@ http://purl.uniprot.org/uniprot/A0A0E3KXV0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS12325 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQA6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS08510 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDI9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/523844:MSTHT_RS10370 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQ26 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS09855 ^@ http://purl.uniprot.org/uniprot/A0A0E3N9W1 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the thiamine-monophosphate kinase family.|||Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. http://togogenome.org/gene/523844:MSTHT_RS05030 ^@ http://purl.uniprot.org/uniprot/A0A0E3NE21 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent DNA ligase family.|||DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. http://togogenome.org/gene/523844:MSTHT_RS07810 ^@ http://purl.uniprot.org/uniprot/A0A0E3H900 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/523844:MSTHT_RS07525 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCA1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family. http://togogenome.org/gene/523844:MSTHT_RS05645 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8R8 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family.|||Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. http://togogenome.org/gene/523844:MSTHT_RS00800 ^@ http://purl.uniprot.org/uniprot/A0A0E3N7A4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTH2 family.|||Cytoplasm|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/523844:MSTHT_RS12065 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQ92 ^@ Function|||Similarity ^@ Belongs to the V-ATPase E subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/523844:MSTHT_RS02440 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAW8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS02725 ^@ http://purl.uniprot.org/uniprot/A0A0E3KNZ2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS01245 ^@ http://purl.uniprot.org/uniprot/A0A0E3KXZ4 ^@ Function ^@ Part of a potassium transport system. http://togogenome.org/gene/523844:MSTHT_RS09770 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCD1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm|||Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.|||Heterodimer of two subunits, one of which binds GTP. http://togogenome.org/gene/523844:MSTHT_RS07530 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8Y9 ^@ Function|||Similarity ^@ Belongs to the eIF-6 family.|||Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. http://togogenome.org/gene/523844:MSTHT_RS08385 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYZ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SPT5 family.|||Belongs to the archaeal Spt5 family.|||Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).|||Stimulates transcription elongation. http://togogenome.org/gene/523844:MSTHT_RS00865 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCW1 ^@ Caution|||Function|||Similarity ^@ Belongs to the CobB/CobQ family. CobQ subfamily.|||Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS04430 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCM6 ^@ Similarity ^@ Belongs to the SIS family. PHI subfamily. http://togogenome.org/gene/523844:MSTHT_RS08695 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPV8 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/523844:MSTHT_RS04165 ^@ http://purl.uniprot.org/uniprot/A0A0E3KP51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS12430 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEI1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the CdhC family.|||Binds 1 [Ni-Fe-S] cluster.|||Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).|||Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex). http://togogenome.org/gene/523844:MSTHT_RS08490 ^@ http://purl.uniprot.org/uniprot/A0A0E3H927 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DtxR/MntR family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS13055 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9J6 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the SMC family. RAD50 subfamily.|||Binds 1 zinc ion per homodimer.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.|||The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer. http://togogenome.org/gene/523844:MSTHT_RS05250 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPE7 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent. http://togogenome.org/gene/523844:MSTHT_RS10475 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQ30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523844:MSTHT_RS05555 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS00140 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBP0 ^@ Similarity ^@ Belongs to the DMRL synthase family. http://togogenome.org/gene/523844:MSTHT_RS01440 ^@ http://purl.uniprot.org/uniprot/A0A0E3KY04 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/523844:MSTHT_RS05990 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPI7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/523844:MSTHT_RS13005 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9J4 ^@ Similarity ^@ Belongs to the NifH/BchL/ChlL family. http://togogenome.org/gene/523844:MSTHT_RS01250 ^@ http://purl.uniprot.org/uniprot/A0A0E3H898 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/523844:MSTHT_RS09025 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPX0 ^@ Function|||Similarity ^@ Belongs to the MfnB family.|||Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). http://togogenome.org/gene/523844:MSTHT_RS11750 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9E7 ^@ Similarity ^@ Belongs to the eIF-2-alpha family. http://togogenome.org/gene/523844:MSTHT_RS00105 ^@ http://purl.uniprot.org/uniprot/A0A0E3KXV1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcL subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/523844:MSTHT_RS12185 ^@ http://purl.uniprot.org/uniprot/A0A0E3NFV0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS02730 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8F6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/523844:MSTHT_RS12000 ^@ http://purl.uniprot.org/uniprot/A0A0E3NFT4 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/523844:MSTHT_RS12710 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9I2 ^@ Function|||Similarity ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. http://togogenome.org/gene/523844:MSTHT_RS05985 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBW4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/523844:MSTHT_RS10025 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCW8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. http://togogenome.org/gene/523844:MSTHT_RS07225 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPP3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS10835 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQ43 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/523844:MSTHT_RS07360 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBI0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. http://togogenome.org/gene/523844:MSTHT_RS12490 ^@ http://purl.uniprot.org/uniprot/A0A0E3ND21 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/523844:MSTHT_RS04210 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDT9 ^@ Similarity ^@ Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. http://togogenome.org/gene/523844:MSTHT_RS09525 ^@ http://purl.uniprot.org/uniprot/A0A0E3N9Q3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal DnaG primase family.|||Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. http://togogenome.org/gene/523844:MSTHT_RS08875 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCJ8 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/523844:MSTHT_RS13560 ^@ http://purl.uniprot.org/uniprot/A0A0E3NG68 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/523844:MSTHT_RS03270 ^@ http://purl.uniprot.org/uniprot/A0A0E3N7V5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.|||Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure. http://togogenome.org/gene/523844:MSTHT_RS12420 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9H1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CdhD family.|||Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).|||Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex. http://togogenome.org/gene/523844:MSTHT_RS10805 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQ41 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS04145 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8L0 ^@ Similarity ^@ Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. http://togogenome.org/gene/523844:MSTHT_RS04880 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8N8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS07245 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8X8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 3 Mg(2+) ions per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS03220 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8H5 ^@ Cofactor|||Function|||Subunit ^@ Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.|||Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/523844:MSTHT_RS13515 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQI1 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/523844:MSTHT_RS06560 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEG4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS00415 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCS7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ThiC family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. http://togogenome.org/gene/523844:MSTHT_RS04525 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDX8 ^@ Cofactor ^@ Binds 1 copper ion per subunit. http://togogenome.org/gene/523844:MSTHT_RS01345 ^@ http://purl.uniprot.org/uniprot/A0A0E3NA00 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.|||Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS08330 ^@ http://purl.uniprot.org/uniprot/A0A0E3N9F8 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/523844:MSTHT_RS03490 ^@ http://purl.uniprot.org/uniprot/A0A0E3KP23 ^@ Similarity ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. http://togogenome.org/gene/523844:MSTHT_RS07350 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8Y2 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent DNA ligase family.|||DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. http://togogenome.org/gene/523844:MSTHT_RS04340 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYG4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/523844:MSTHT_RS02305 ^@ http://purl.uniprot.org/uniprot/A0A0E3KNX0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/523844:MSTHT_RS11055 ^@ http://purl.uniprot.org/uniprot/A0A0E3NA73 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/523844:MSTHT_RS05330 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8Q5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/523844:MSTHT_RS01695 ^@ http://purl.uniprot.org/uniprot/A0A0E3NA34 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/523844:MSTHT_RS04080 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAR3 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/523844:MSTHT_RS08640 ^@ http://purl.uniprot.org/uniprot/A0A0E3NC21 ^@ Similarity|||Subunit ^@ Belongs to the methyl-coenzyme M reductase gamma subunit family.|||Hexamer of two alpha, two beta, and two gamma chains.|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers. http://togogenome.org/gene/523844:MSTHT_RS10610 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQ34 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 4 family.|||Binds 1 zinc ion per subunit.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/523844:MSTHT_RS09195 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS11170 ^@ http://purl.uniprot.org/uniprot/A0A0E3NFK9 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/523844:MSTHT_RS07375 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8Y3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SepCysS family.|||Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).|||Homodimer. Interacts with SepRS. http://togogenome.org/gene/523844:MSTHT_RS06185 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPJ9 ^@ Similarity ^@ Belongs to the glucose-1-phosphate thymidylyltransferase family. http://togogenome.org/gene/523844:MSTHT_RS06550 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8V2 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS12085 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZB9 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. http://togogenome.org/gene/523844:MSTHT_RS10660 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS12485 ^@ http://purl.uniprot.org/uniprot/A0A0E3NEI5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/523844:MSTHT_RS10670 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9A7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrE family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/523844:MSTHT_RS06090 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPJ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||Located at the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/523844:MSTHT_RS05090 ^@ http://purl.uniprot.org/uniprot/A0A0E3NE29 ^@ Function|||Subcellular Location Annotation ^@ Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-exporting P-type ATPase A (CopA).|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS13405 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZI5 ^@ Similarity ^@ Belongs to the HMG-CoA reductase family. http://togogenome.org/gene/523844:MSTHT_RS03765 ^@ http://purl.uniprot.org/uniprot/A0A0E3N7Z6 ^@ Similarity ^@ Belongs to the oxoprolinase family. http://togogenome.org/gene/523844:MSTHT_RS10315 ^@ http://purl.uniprot.org/uniprot/A0A0E3NA08 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/523844:MSTHT_RS03895 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCF1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS04650 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8N0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/523844:MSTHT_RS12840 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAQ4 ^@ Function|||Similarity ^@ Belongs to the GTP-dependent DPCK family.|||Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). http://togogenome.org/gene/523844:MSTHT_RS12415 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQB2 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 [4Fe-4S] cluster.|||Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).|||Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. http://togogenome.org/gene/523844:MSTHT_RS11410 ^@ http://purl.uniprot.org/uniprot/A0A0E3H9D4 ^@ Similarity ^@ Belongs to the LarC family. http://togogenome.org/gene/523844:MSTHT_RS08335 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPU4 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/523844:MSTHT_RS01140 ^@ http://purl.uniprot.org/uniprot/A0A0E3N7C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4 family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS01880 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8C3 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Arsenite methyltransferase family. http://togogenome.org/gene/523844:MSTHT_RS12390 ^@ http://purl.uniprot.org/uniprot/A0A0E3ND15 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/523844:MSTHT_RS01025 ^@ http://purl.uniprot.org/uniprot/A0A0E3N7C1 ^@ Caution|||Function|||Similarity ^@ Belongs to the transcriptional regulatory CopG/NikR family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Transcriptional regulator. http://togogenome.org/gene/523844:MSTHT_RS03975 ^@ http://purl.uniprot.org/uniprot/A0A0E3KP42 ^@ Function|||Subcellular Location Annotation ^@ F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS12265 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/523844:MSTHT_RS08625 ^@ http://purl.uniprot.org/uniprot/A0A0E3NDK1 ^@ Similarity|||Subunit ^@ Belongs to the methyl-coenzyme M reductase beta subunit family.|||Hexamer of two alpha, two beta, and two gamma chains.|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers. http://togogenome.org/gene/523844:MSTHT_RS06035 ^@ http://purl.uniprot.org/uniprot/A0A0E3NB95 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/523844:MSTHT_RS01935 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/523844:MSTHT_RS05905 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8S8 ^@ Similarity ^@ Belongs to the HypD family. http://togogenome.org/gene/523844:MSTHT_RS02365 ^@ http://purl.uniprot.org/uniprot/A0A0E3ND87 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). http://togogenome.org/gene/523844:MSTHT_RS07840 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBQ5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. http://togogenome.org/gene/523844:MSTHT_RS02375 ^@ http://purl.uniprot.org/uniprot/A0A0E3KNX2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS07040 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYU9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the quinolinate synthase family. Type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS03915 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAP3 ^@ Similarity ^@ Belongs to the CutA family. http://togogenome.org/gene/523844:MSTHT_RS13490 ^@ http://purl.uniprot.org/uniprot/A0A0E3NG64 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523844:MSTHT_RS08420 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYZ7 ^@ Similarity ^@ Belongs to the SAM hydrolase / SAM-dependent halogenase family. http://togogenome.org/gene/523844:MSTHT_RS12815 ^@ http://purl.uniprot.org/uniprot/A0A0E3ND52 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/523844:MSTHT_RS09205 ^@ http://purl.uniprot.org/uniprot/A0A0E3H954 ^@ Similarity ^@ Belongs to the methylamine corrinoid protein family. http://togogenome.org/gene/523844:MSTHT_RS07980 ^@ http://purl.uniprot.org/uniprot/A0A0E3KPS3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA. http://togogenome.org/gene/523844:MSTHT_RS12300 ^@ http://purl.uniprot.org/uniprot/A0A0E3NFV8 ^@ Similarity ^@ Belongs to the DeoC/FbaB aldolase family. http://togogenome.org/gene/523844:MSTHT_RS09620 ^@ http://purl.uniprot.org/uniprot/A0A0E3KZ36 ^@ Similarity ^@ Belongs to the UPF0200 family. http://togogenome.org/gene/523844:MSTHT_RS12460 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAL6 ^@ Similarity ^@ Belongs to the UPF0285 family. http://togogenome.org/gene/523844:MSTHT_RS00125 ^@ http://purl.uniprot.org/uniprot/A0A0E3N766 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/523844:MSTHT_RS02325 ^@ http://purl.uniprot.org/uniprot/A0A0E3NC19 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. http://togogenome.org/gene/523844:MSTHT_RS13480 ^@ http://purl.uniprot.org/uniprot/A0A0E3KQH8 ^@ Similarity ^@ In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/523844:MSTHT_RS02980 ^@ http://purl.uniprot.org/uniprot/A0A0E3NC73 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).|||Belongs to the TDD superfamily. TSR3 family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523844:MSTHT_RS04845 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBP6 ^@ Function|||Similarity ^@ Belongs to the glutaredoxin family.|||Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro. http://togogenome.org/gene/523844:MSTHT_RS01705 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8B6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp41 subfamily.|||Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm http://togogenome.org/gene/523844:MSTHT_RS09615 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCB5 ^@ Similarity ^@ Belongs to the UPF0201 family. http://togogenome.org/gene/523844:MSTHT_RS07510 ^@ http://purl.uniprot.org/uniprot/A0A0E3H8Y8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS19 family.|||May be involved in maturation of the 30S ribosomal subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/523844:MSTHT_RS00815 ^@ http://purl.uniprot.org/uniprot/A0A0E3NBS5 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.|||Cytoplasm|||Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.|||In Archaea the pyridoxal phosphate cofactor is not covalently bound to Lys but ligated by other amino acids.|||Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. http://togogenome.org/gene/523844:MSTHT_RS04655 ^@ http://purl.uniprot.org/uniprot/A0A0E3NAY2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/523844:MSTHT_RS08940 ^@ http://purl.uniprot.org/uniprot/A0A0E3NF21 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/523844:MSTHT_RS07685 ^@ http://purl.uniprot.org/uniprot/A0A0E3NCB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523844:MSTHT_RS03670 ^@ http://purl.uniprot.org/uniprot/A0A0E3KYC4 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.|||Belongs to the peptidase S16 family.|||By heat shock.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity.|||Membrane