http://togogenome.org/gene/546269:HMPREF0389_RS07265 ^@ http://purl.uniprot.org/uniprot/D6GQM0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of glycine to tRNA(Gly).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/546269:HMPREF0389_RS06750 ^@ http://purl.uniprot.org/uniprot/D6GQB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS06080 ^@ http://purl.uniprot.org/uniprot/E8RKD0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspH family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. http://togogenome.org/gene/546269:HMPREF0389_RS06430 ^@ http://purl.uniprot.org/uniprot/D6GQ50 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/546269:HMPREF0389_RS03275 ^@ http://purl.uniprot.org/uniprot/D6GU59 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/546269:HMPREF0389_RS03980 ^@ http://purl.uniprot.org/uniprot/D6GTU2 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the Rho family.|||Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.|||Homohexamer. The homohexamer assembles into an open ring structure.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS07360 ^@ http://purl.uniprot.org/uniprot/D6GQN9 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/546269:HMPREF0389_RS06380 ^@ http://purl.uniprot.org/uniprot/D6GQ41 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/546269:HMPREF0389_RS01300 ^@ http://purl.uniprot.org/uniprot/D6GS16 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the DnaG primase family.|||Binds 1 zinc ion per monomer.|||Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.|||Monomer. Interacts with DnaB.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/546269:HMPREF0389_RS01745 ^@ http://purl.uniprot.org/uniprot/D6GRS7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS00690 ^@ http://purl.uniprot.org/uniprot/D6GSD6 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/546269:HMPREF0389_RS02870 ^@ http://purl.uniprot.org/uniprot/D6GR58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylate kinase family.|||Cytoplasm|||Essential for recycling GMP and indirectly, cGMP. http://togogenome.org/gene/546269:HMPREF0389_RS02225 ^@ http://purl.uniprot.org/uniprot/D6GRI4 ^@ Similarity ^@ Belongs to the type IA topoisomerase family. http://togogenome.org/gene/546269:HMPREF0389_RS05180 ^@ http://purl.uniprot.org/uniprot/D6GSL4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methylthiotransferase family. MiaB subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.|||Cytoplasm|||Monomer. http://togogenome.org/gene/546269:HMPREF0389_RS02125 ^@ http://purl.uniprot.org/uniprot/D6GRK4 ^@ Caution|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated Cas9 family.|||Belongs to the CRISPR-associated protein Cas9 family. Subtype II-A subfamily.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer; Cas9 is inactive in the absence of the 2 guide RNAs (gRNA). Cas9 recognizes the protospacer adjacent motif (PAM) in the CRISPR repeat sequences to help distinguish self versus nonself, as targets within the bacterial CRISPR locus do not have PAMs. PAM recognition is also required for catalytic activity.|||Has 2 endonuclease domains. The discontinuous RuvC-like domain cleaves the target DNA noncomplementary to crRNA while the HNH nuclease domain cleaves the target DNA complementary to crRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Binds crRNA and tracrRNA. http://togogenome.org/gene/546269:HMPREF0389_RS05515 ^@ http://purl.uniprot.org/uniprot/D6GPL5 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/546269:HMPREF0389_RS03835 ^@ http://purl.uniprot.org/uniprot/D6GTW8 ^@ Similarity ^@ Belongs to the low molecular weight phosphotyrosine protein phosphatase family. http://togogenome.org/gene/546269:HMPREF0389_RS00210 ^@ http://purl.uniprot.org/uniprot/D6GSR8 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/546269:HMPREF0389_RS01210 ^@ http://purl.uniprot.org/uniprot/D6GS34 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/546269:HMPREF0389_RS02530 ^@ http://purl.uniprot.org/uniprot/D6GRC5 ^@ Similarity ^@ Belongs to the DprA/Smf family. http://togogenome.org/gene/546269:HMPREF0389_RS00525 ^@ http://purl.uniprot.org/uniprot/D6GSG9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M3B family.|||Binds 1 zinc ion.|||Has oligopeptidase activity and degrades a variety of small bioactive peptides. http://togogenome.org/gene/546269:HMPREF0389_RS02325 ^@ http://purl.uniprot.org/uniprot/D6GRG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS02800 ^@ http://purl.uniprot.org/uniprot/D6GR72 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS02925 ^@ http://purl.uniprot.org/uniprot/D6GR47 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methylthiotransferase family. RimO subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS08615 ^@ http://purl.uniprot.org/uniprot/D6GSW6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS02630 ^@ http://purl.uniprot.org/uniprot/D6GRA5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer. http://togogenome.org/gene/546269:HMPREF0389_RS02000 ^@ http://purl.uniprot.org/uniprot/D6GRN0 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/546269:HMPREF0389_RS02555 ^@ http://purl.uniprot.org/uniprot/D6GRC0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS01540 ^@ http://purl.uniprot.org/uniprot/D6GRW9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/546269:HMPREF0389_RS06285 ^@ http://purl.uniprot.org/uniprot/D6GQ21 ^@ Similarity ^@ Belongs to the desulfoferrodoxin family. http://togogenome.org/gene/546269:HMPREF0389_RS06435 ^@ http://purl.uniprot.org/uniprot/D6GQ51 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/546269:HMPREF0389_RS06215 ^@ http://purl.uniprot.org/uniprot/D6GQ05 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional regulatory Rex family.|||Cytoplasm|||Homodimer.|||Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. http://togogenome.org/gene/546269:HMPREF0389_RS06685 ^@ http://purl.uniprot.org/uniprot/D6GQA1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS06395 ^@ http://purl.uniprot.org/uniprot/D6GQ44 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/546269:HMPREF0389_RS00855 ^@ http://purl.uniprot.org/uniprot/D6GSA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate 5-kinase family.|||Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS04260 ^@ http://purl.uniprot.org/uniprot/D6GTP5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueA family.|||Cytoplasm|||Monomer.|||Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). http://togogenome.org/gene/546269:HMPREF0389_RS05040 ^@ http://purl.uniprot.org/uniprot/D6GU70 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/546269:HMPREF0389_RS04270 ^@ http://purl.uniprot.org/uniprot/D6GTP3 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/546269:HMPREF0389_RS00910 ^@ http://purl.uniprot.org/uniprot/D6GS92 ^@ Similarity ^@ Belongs to the peptidase M18 family. http://togogenome.org/gene/546269:HMPREF0389_RS02940 ^@ http://purl.uniprot.org/uniprot/D6GR44 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS03355 ^@ http://purl.uniprot.org/uniprot/D6GU43 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/546269:HMPREF0389_RS01175 ^@ http://purl.uniprot.org/uniprot/D6GS41 ^@ Similarity|||Subunit ^@ Belongs to the UPF0210 family.|||Homodimer. http://togogenome.org/gene/546269:HMPREF0389_RS02815 ^@ http://purl.uniprot.org/uniprot/D6GR69 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.|||Could methylate the ribose at the nucleotide 34 wobble position in tRNA.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS00765 ^@ http://purl.uniprot.org/uniprot/D6GSC2 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/546269:HMPREF0389_RS04245 ^@ http://purl.uniprot.org/uniprot/D6GTP8 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvA family.|||Cytoplasm|||Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.|||Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA. http://togogenome.org/gene/546269:HMPREF0389_RS06355 ^@ http://purl.uniprot.org/uniprot/E8RK56 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/546269:HMPREF0389_RS05200 ^@ http://purl.uniprot.org/uniprot/D6GSL8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/546269:HMPREF0389_RS06400 ^@ http://purl.uniprot.org/uniprot/D6GQ45 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/546269:HMPREF0389_RS06480 ^@ http://purl.uniprot.org/uniprot/D6GQ60 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/546269:HMPREF0389_RS04220 ^@ http://purl.uniprot.org/uniprot/D6GTQ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase A chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS08605 ^@ http://purl.uniprot.org/uniprot/D6GSW8 ^@ Similarity ^@ Belongs to the ParB family. http://togogenome.org/gene/546269:HMPREF0389_RS07345 ^@ http://purl.uniprot.org/uniprot/D6GQN6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS02015 ^@ http://purl.uniprot.org/uniprot/D6GRM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VirD4/TraG family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS02185 ^@ http://purl.uniprot.org/uniprot/D6GRJ2 ^@ Function|||Similarity ^@ Belongs to the 'phage' integrase family.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. http://togogenome.org/gene/546269:HMPREF0389_RS04250 ^@ http://purl.uniprot.org/uniprot/D6GTP7 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvB family.|||Cytoplasm|||Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.|||Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA. http://togogenome.org/gene/546269:HMPREF0389_RS07830 ^@ http://purl.uniprot.org/uniprot/D6GQX9 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.|||Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. http://togogenome.org/gene/546269:HMPREF0389_RS04490 ^@ http://purl.uniprot.org/uniprot/D6GTK0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS06045 ^@ http://purl.uniprot.org/uniprot/D6GPX4 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/546269:HMPREF0389_RS06590 ^@ http://purl.uniprot.org/uniprot/E8RK60 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/546269:HMPREF0389_RS02625 ^@ http://purl.uniprot.org/uniprot/D6GRA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS03830 ^@ http://purl.uniprot.org/uniprot/D6GTX0 ^@ Similarity ^@ Belongs to the UPF0167 family. http://togogenome.org/gene/546269:HMPREF0389_RS00635 ^@ http://purl.uniprot.org/uniprot/D6GSE7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.|||Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form 5-methoxyuridine (mo5U) at position 34 in tRNAs.|||Homodimer. http://togogenome.org/gene/546269:HMPREF0389_RS01705 ^@ http://purl.uniprot.org/uniprot/D6GRT5 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/546269:HMPREF0389_RS03105 ^@ http://purl.uniprot.org/uniprot/D6GR10 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/546269:HMPREF0389_RS00755 ^@ http://purl.uniprot.org/uniprot/D6GSC4 ^@ Function|||Similarity ^@ Belongs to the NAD-dependent DNA ligase family. LigA subfamily.|||DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. http://togogenome.org/gene/546269:HMPREF0389_RS06500 ^@ http://purl.uniprot.org/uniprot/D6GQ64 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/546269:HMPREF0389_RS00770 ^@ http://purl.uniprot.org/uniprot/D6GSC1 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/546269:HMPREF0389_RS00260 ^@ http://purl.uniprot.org/uniprot/D6GSQ8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A8 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This protein specifically catalyzes the removal of signal peptides from prolipoproteins. http://togogenome.org/gene/546269:HMPREF0389_RS06055 ^@ http://purl.uniprot.org/uniprot/D6GPX6 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/546269:HMPREF0389_RS08420 ^@ http://purl.uniprot.org/uniprot/D6GT06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.|||Cell membrane http://togogenome.org/gene/546269:HMPREF0389_RS02150 ^@ http://purl.uniprot.org/uniprot/D6GRJ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS07930 ^@ http://purl.uniprot.org/uniprot/E8RK79 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS01905 ^@ http://purl.uniprot.org/uniprot/D6GRP9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS06465 ^@ http://purl.uniprot.org/uniprot/D6GQ57 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/546269:HMPREF0389_RS05155 ^@ http://purl.uniprot.org/uniprot/D6GSK9 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/546269:HMPREF0389_RS06410 ^@ http://purl.uniprot.org/uniprot/D6GQ47 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/546269:HMPREF0389_RS06925 ^@ http://purl.uniprot.org/uniprot/D6GQE8 ^@ Caution|||Function|||Similarity ^@ Belongs to the DXR family.|||Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS01365 ^@ http://purl.uniprot.org/uniprot/D6GS03 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/546269:HMPREF0389_RS06570 ^@ http://purl.uniprot.org/uniprot/D6GQ79 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/546269:HMPREF0389_RS02025 ^@ http://purl.uniprot.org/uniprot/D6GRM5 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/546269:HMPREF0389_RS04430 ^@ http://purl.uniprot.org/uniprot/D6GTL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS01510 ^@ http://purl.uniprot.org/uniprot/D6GRX5 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.|||Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/546269:HMPREF0389_RS05050 ^@ http://purl.uniprot.org/uniprot/D6GU68 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Cytoplasm|||Homodimer.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/546269:HMPREF0389_RS00035 ^@ http://purl.uniprot.org/uniprot/D6GSV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS00725 ^@ http://purl.uniprot.org/uniprot/E8RK64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/546269:HMPREF0389_RS01435 ^@ http://purl.uniprot.org/uniprot/D6GRZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.|||Cytoplasm|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. http://togogenome.org/gene/546269:HMPREF0389_RS01605 ^@ http://purl.uniprot.org/uniprot/D6GRV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sbp family.|||Cell membrane http://togogenome.org/gene/546269:HMPREF0389_RS01635 ^@ http://purl.uniprot.org/uniprot/D6GRV0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS05140 ^@ http://purl.uniprot.org/uniprot/D6GSK6 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/546269:HMPREF0389_RS06715 ^@ http://purl.uniprot.org/uniprot/D6GQA7 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/546269:HMPREF0389_RS03915 ^@ http://purl.uniprot.org/uniprot/D6GTV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribonuclease III family.|||Cytoplasm|||Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.|||Homodimer. http://togogenome.org/gene/546269:HMPREF0389_RS00495 ^@ http://purl.uniprot.org/uniprot/D6GSH5 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. IspE subfamily.|||Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. http://togogenome.org/gene/546269:HMPREF0389_RS08230 ^@ http://purl.uniprot.org/uniprot/D6GT41 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS02115 ^@ http://purl.uniprot.org/uniprot/D6GRK6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/546269:HMPREF0389_RS05890 ^@ http://purl.uniprot.org/uniprot/D6GPT9 ^@ Function|||Similarity ^@ Belongs to the RmuC family.|||Involved in DNA recombination. http://togogenome.org/gene/546269:HMPREF0389_RS08120 ^@ http://purl.uniprot.org/uniprot/D6GT63 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. http://togogenome.org/gene/546269:HMPREF0389_RS06490 ^@ http://purl.uniprot.org/uniprot/D6GQ62 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/546269:HMPREF0389_RS06415 ^@ http://purl.uniprot.org/uniprot/E8RK57 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/546269:HMPREF0389_RS07900 ^@ http://purl.uniprot.org/uniprot/D6GQZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS03260 ^@ http://purl.uniprot.org/uniprot/D6GU62 ^@ Similarity ^@ Belongs to the CinA family. http://togogenome.org/gene/546269:HMPREF0389_RS01665 ^@ http://purl.uniprot.org/uniprot/D6GRU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Lgt family.|||Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.|||Cell membrane http://togogenome.org/gene/546269:HMPREF0389_RS07285 ^@ http://purl.uniprot.org/uniprot/D6GQM4 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/546269:HMPREF0389_RS07145 ^@ http://purl.uniprot.org/uniprot/D6GQJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNT transporter (TC 2.A.44) family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS05350 ^@ http://purl.uniprot.org/uniprot/D6GPI6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA polymerase type-A family.|||In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.|||Single-chain monomer with multiple functions. http://togogenome.org/gene/546269:HMPREF0389_RS04110 ^@ http://purl.uniprot.org/uniprot/D6GTR8 ^@ Similarity ^@ Belongs to the UDP-N-acetylglucosamine 2-epimerase family. http://togogenome.org/gene/546269:HMPREF0389_RS05135 ^@ http://purl.uniprot.org/uniprot/D6GSK5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS01660 ^@ http://purl.uniprot.org/uniprot/D6GRU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmH family.|||Cytoplasm|||Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. http://togogenome.org/gene/546269:HMPREF0389_RS06830 ^@ http://purl.uniprot.org/uniprot/D6GQD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS07325 ^@ http://purl.uniprot.org/uniprot/D6GQN2 ^@ Function|||Similarity ^@ Belongs to the PNP/MTAP phosphorylase family.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/546269:HMPREF0389_RS01580 ^@ http://purl.uniprot.org/uniprot/D6GRW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS02750 ^@ http://purl.uniprot.org/uniprot/D6GR83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.|||Catalyzes the sodium-dependent transport of glutamate.|||Cell membrane http://togogenome.org/gene/546269:HMPREF0389_RS04630 ^@ http://purl.uniprot.org/uniprot/D6GTH2 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. http://togogenome.org/gene/546269:HMPREF0389_RS07330 ^@ http://purl.uniprot.org/uniprot/D6GQN3 ^@ Similarity ^@ Belongs to the BMP lipoprotein family. http://togogenome.org/gene/546269:HMPREF0389_RS08430 ^@ http://purl.uniprot.org/uniprot/D6GT03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS03350 ^@ http://purl.uniprot.org/uniprot/D6GU44 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. http://togogenome.org/gene/546269:HMPREF0389_RS00880 ^@ http://purl.uniprot.org/uniprot/D6GS98 ^@ Similarity ^@ Belongs to the ArsC family. http://togogenome.org/gene/546269:HMPREF0389_RS05505 ^@ http://purl.uniprot.org/uniprot/D6GPL3 ^@ Function ^@ Abolishes the inhibitory effect of tetracyclin on protein synthesis by a non-covalent modification of the ribosomes. http://togogenome.org/gene/546269:HMPREF0389_RS06785 ^@ http://purl.uniprot.org/uniprot/D6GQC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS03785 ^@ http://purl.uniprot.org/uniprot/D6GTX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. ArgB subfamily.|||Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS00150 ^@ http://purl.uniprot.org/uniprot/D6GST0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/546269:HMPREF0389_RS07260 ^@ http://purl.uniprot.org/uniprot/D6GQL9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS08440 ^@ http://purl.uniprot.org/uniprot/D6GT01 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with bS18 to 16S ribosomal RNA. http://togogenome.org/gene/546269:HMPREF0389_RS06585 ^@ http://purl.uniprot.org/uniprot/E8RK59 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. http://togogenome.org/gene/546269:HMPREF0389_RS06260 ^@ http://purl.uniprot.org/uniprot/D6GQ15 ^@ Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. http://togogenome.org/gene/546269:HMPREF0389_RS01380 ^@ http://purl.uniprot.org/uniprot/D6GS00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS05195 ^@ http://purl.uniprot.org/uniprot/D6GSL7 ^@ Function|||Similarity|||Subunit ^@ Associates with stalled 50S ribosomal subunits.|||Belongs to the NEMF family.|||Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits. http://togogenome.org/gene/546269:HMPREF0389_RS02720 ^@ http://purl.uniprot.org/uniprot/D6GR87 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/546269:HMPREF0389_RS00815 ^@ http://purl.uniprot.org/uniprot/D6GSB1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.|||An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.|||Belongs to the DTD family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/546269:HMPREF0389_RS00385 ^@ http://purl.uniprot.org/uniprot/D6GSJ7 ^@ Similarity ^@ Belongs to the transpeptidase family. http://togogenome.org/gene/546269:HMPREF0389_RS02980 ^@ http://purl.uniprot.org/uniprot/D6GR36 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HSP33 family.|||Cytoplasm|||Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.|||Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive. http://togogenome.org/gene/546269:HMPREF0389_RS00670 ^@ http://purl.uniprot.org/uniprot/D6GSE0 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS04515 ^@ http://purl.uniprot.org/uniprot/D6GTJ5 ^@ Similarity ^@ Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. http://togogenome.org/gene/546269:HMPREF0389_RS02510 ^@ http://purl.uniprot.org/uniprot/D6GRC9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.|||Cytoplasm|||Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.|||Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. http://togogenome.org/gene/546269:HMPREF0389_RS08085 ^@ http://purl.uniprot.org/uniprot/D6GT70 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/546269:HMPREF0389_RS04810 ^@ http://purl.uniprot.org/uniprot/D6GTD4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/546269:HMPREF0389_RS07470 ^@ http://purl.uniprot.org/uniprot/D6GQR3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HsdR family.|||Subunit R is required for both nuclease and ATPase activities, but not for modification.|||The type I restriction/modification system is composed of three polypeptides R, M and S. http://togogenome.org/gene/546269:HMPREF0389_RS01650 ^@ http://purl.uniprot.org/uniprot/D6GRU7 ^@ Similarity ^@ Belongs to the transpeptidase family. http://togogenome.org/gene/546269:HMPREF0389_RS06280 ^@ http://purl.uniprot.org/uniprot/D6GQ19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS05865 ^@ http://purl.uniprot.org/uniprot/D6GPT4 ^@ Function|||Similarity ^@ Belongs to the NusB family.|||Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. http://togogenome.org/gene/546269:HMPREF0389_RS00065 ^@ http://purl.uniprot.org/uniprot/D6GSU7 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/546269:HMPREF0389_RS05405 ^@ http://purl.uniprot.org/uniprot/D6GPJ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/546269:HMPREF0389_RS01130 ^@ http://purl.uniprot.org/uniprot/D6GS50 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. UvrA family.|||Cytoplasm|||Forms a heterotetramer with UvrB during the search for lesions.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. http://togogenome.org/gene/546269:HMPREF0389_RS05170 ^@ http://purl.uniprot.org/uniprot/D6GSL2 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/546269:HMPREF0389_RS01225 ^@ http://purl.uniprot.org/uniprot/D6GS31 ^@ Similarity ^@ Belongs to the pyruvate kinase family.|||In the C-terminal section; belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/546269:HMPREF0389_RS03505 ^@ http://purl.uniprot.org/uniprot/D6GU36 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit.|||Binds 2 divalent ions per subunit.|||Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.|||Cytoplasm|||Homotetramer; dimer of dimers. http://togogenome.org/gene/546269:HMPREF0389_RS07675 ^@ http://purl.uniprot.org/uniprot/D6GQV0 ^@ Similarity ^@ Belongs to the ArsC family. http://togogenome.org/gene/546269:HMPREF0389_RS00695 ^@ http://purl.uniprot.org/uniprot/D6GSD5 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/546269:HMPREF0389_RS05290 ^@ http://purl.uniprot.org/uniprot/D6GSN6 ^@ Similarity ^@ In the C-terminal section; belongs to the transpeptidase family.|||In the N-terminal section; belongs to the glycosyltransferase 51 family. http://togogenome.org/gene/546269:HMPREF0389_RS06655 ^@ http://purl.uniprot.org/uniprot/D6GQ95 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MetA family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. http://togogenome.org/gene/546269:HMPREF0389_RS01360 ^@ http://purl.uniprot.org/uniprot/D6GS04 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. PrmA family.|||Cytoplasm|||Methylates ribosomal protein L11. http://togogenome.org/gene/546269:HMPREF0389_RS01775 ^@ http://purl.uniprot.org/uniprot/D6GRS0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS04185 ^@ http://purl.uniprot.org/uniprot/D6GTR0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. http://togogenome.org/gene/546269:HMPREF0389_RS07335 ^@ http://purl.uniprot.org/uniprot/D6GQN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.|||Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS02675 ^@ http://purl.uniprot.org/uniprot/D6GR96 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/546269:HMPREF0389_RS04265 ^@ http://purl.uniprot.org/uniprot/D6GTP4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).|||Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1. http://togogenome.org/gene/546269:HMPREF0389_RS01190 ^@ http://purl.uniprot.org/uniprot/D6GS38 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/546269:HMPREF0389_RS03250 ^@ http://purl.uniprot.org/uniprot/D6GU64 ^@ Similarity ^@ Belongs to the Dps family. http://togogenome.org/gene/546269:HMPREF0389_RS07250 ^@ http://purl.uniprot.org/uniprot/D6GQL7 ^@ Similarity ^@ Belongs to the UPF0597 family. http://togogenome.org/gene/546269:HMPREF0389_RS06420 ^@ http://purl.uniprot.org/uniprot/D6GQ48 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/546269:HMPREF0389_RS07875 ^@ http://purl.uniprot.org/uniprot/D6GQY7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS02620 ^@ http://purl.uniprot.org/uniprot/D6GRA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS03565 ^@ http://purl.uniprot.org/uniprot/D6GU24 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HCP family.|||Binds 1 [4Fe-4S] cluster.|||Binds 1 hybrid [4Fe-2O-2S] cluster.|||Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS05745 ^@ http://purl.uniprot.org/uniprot/D6GPQ8 ^@ Function|||Similarity ^@ Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.|||Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. http://togogenome.org/gene/546269:HMPREF0389_RS02690 ^@ http://purl.uniprot.org/uniprot/D6GR93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Cytoplasm|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. http://togogenome.org/gene/546269:HMPREF0389_RS08100 ^@ http://purl.uniprot.org/uniprot/D6GT67 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/546269:HMPREF0389_RS05800 ^@ http://purl.uniprot.org/uniprot/D6GPS1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Belongs to the RNase PH family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Homohexameric ring arranged as a trimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/546269:HMPREF0389_RS07130 ^@ http://purl.uniprot.org/uniprot/D6GQJ0 ^@ Similarity ^@ Belongs to the UPF0473 family. http://togogenome.org/gene/546269:HMPREF0389_RS00585 ^@ http://purl.uniprot.org/uniprot/D6GSF7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/546269:HMPREF0389_RS02685 ^@ http://purl.uniprot.org/uniprot/D6GR94 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/546269:HMPREF0389_RS06105 ^@ http://purl.uniprot.org/uniprot/D6GPY4 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/546269:HMPREF0389_RS05585 ^@ http://purl.uniprot.org/uniprot/D6GPM8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS00885 ^@ http://purl.uniprot.org/uniprot/D6GS97 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the HPrK/P family.|||Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.|||Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.|||Homohexamer.|||The Walker A ATP-binding motif also binds Pi and PPi. http://togogenome.org/gene/546269:HMPREF0389_RS06985 ^@ http://purl.uniprot.org/uniprot/D6GQG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccA family.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS06630 ^@ http://purl.uniprot.org/uniprot/D6GQ90 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/546269:HMPREF0389_RS04180 ^@ http://purl.uniprot.org/uniprot/D6GTR1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/546269:HMPREF0389_RS06710 ^@ http://purl.uniprot.org/uniprot/D6GQA6 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion per subunit.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.|||In the C-terminal section; belongs to the GTP cyclohydrolase II family.|||In the N-terminal section; belongs to the DHBP synthase family. http://togogenome.org/gene/546269:HMPREF0389_RS08455 ^@ http://purl.uniprot.org/uniprot/D6GSZ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS03000 ^@ http://purl.uniprot.org/uniprot/D6GR32 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS06450 ^@ http://purl.uniprot.org/uniprot/D6GQ54 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/546269:HMPREF0389_RS01470 ^@ http://purl.uniprot.org/uniprot/D6GRY3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Iojap/RsfS family.|||Cytoplasm|||Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.|||Interacts with ribosomal protein uL14 (rplN). http://togogenome.org/gene/546269:HMPREF0389_RS06640 ^@ http://purl.uniprot.org/uniprot/D6GQ92 ^@ Function|||Similarity ^@ Belongs to the helicase family. RecG subfamily.|||Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA). http://togogenome.org/gene/546269:HMPREF0389_RS08105 ^@ http://purl.uniprot.org/uniprot/D6GT66 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/546269:HMPREF0389_RS03075 ^@ http://purl.uniprot.org/uniprot/D6GR17 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS01035 ^@ http://purl.uniprot.org/uniprot/D6GS70 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/546269:HMPREF0389_RS01645 ^@ http://purl.uniprot.org/uniprot/D6GRU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurF subfamily.|||Cytoplasm|||Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. http://togogenome.org/gene/546269:HMPREF0389_RS03725 ^@ http://purl.uniprot.org/uniprot/D6GTZ3 ^@ Similarity ^@ Belongs to the FBPase class 2 family. http://togogenome.org/gene/546269:HMPREF0389_RS05675 ^@ http://purl.uniprot.org/uniprot/D6GPP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VirD4/TraG family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS04015 ^@ http://purl.uniprot.org/uniprot/D6GTT6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/546269:HMPREF0389_RS04645 ^@ http://purl.uniprot.org/uniprot/D6GTG8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/546269:HMPREF0389_RS03595 ^@ http://purl.uniprot.org/uniprot/D6GU18 ^@ Similarity ^@ Belongs to the iron-sulfur dependent L-serine dehydratase family. http://togogenome.org/gene/546269:HMPREF0389_RS05070 ^@ http://purl.uniprot.org/uniprot/E8RKB1 ^@ Similarity ^@ Belongs to the Dps family. http://togogenome.org/gene/546269:HMPREF0389_RS01230 ^@ http://purl.uniprot.org/uniprot/D6GS30 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS01730 ^@ http://purl.uniprot.org/uniprot/D6GRT0 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/546269:HMPREF0389_RS00665 ^@ http://purl.uniprot.org/uniprot/D6GSE1 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/546269:HMPREF0389_RS03645 ^@ http://purl.uniprot.org/uniprot/D6GU08 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS08540 ^@ http://purl.uniprot.org/uniprot/D6GSY1 ^@ Cofactor|||Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/546269:HMPREF0389_RS04290 ^@ http://purl.uniprot.org/uniprot/E8RKA1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Belongs to the SecD/SecF family. SecF subfamily.|||Cell membrane|||Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/546269:HMPREF0389_RS05575 ^@ http://purl.uniprot.org/uniprot/D6GPM6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS06700 ^@ http://purl.uniprot.org/uniprot/D6GQA4 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion.|||Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.|||In the C-terminal section; belongs to the HTP reductase family.|||In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/546269:HMPREF0389_RS05145 ^@ http://purl.uniprot.org/uniprot/D6GSK7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/546269:HMPREF0389_RS07795 ^@ http://purl.uniprot.org/uniprot/D6GQX3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS00790 ^@ http://purl.uniprot.org/uniprot/D6GSB6 ^@ Function ^@ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. http://togogenome.org/gene/546269:HMPREF0389_RS06800 ^@ http://purl.uniprot.org/uniprot/D6GQC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the energy-coupling factor EcfT family.|||Cell membrane|||Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).|||Membrane|||Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. http://togogenome.org/gene/546269:HMPREF0389_RS08115 ^@ http://purl.uniprot.org/uniprot/D6GT64 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. http://togogenome.org/gene/546269:HMPREF0389_RS04725 ^@ http://purl.uniprot.org/uniprot/D6GTF2 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/546269:HMPREF0389_RS03530 ^@ http://purl.uniprot.org/uniprot/D6GU31 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/546269:HMPREF0389_RS08110 ^@ http://purl.uniprot.org/uniprot/D6GT65 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/546269:HMPREF0389_RS06405 ^@ http://purl.uniprot.org/uniprot/D6GQ46 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/546269:HMPREF0389_RS05365 ^@ http://purl.uniprot.org/uniprot/D6GPI8 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/546269:HMPREF0389_RS02640 ^@ http://purl.uniprot.org/uniprot/D6GRA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/546269:HMPREF0389_RS03280 ^@ http://purl.uniprot.org/uniprot/D6GU58 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/546269:HMPREF0389_RS02520 ^@ http://purl.uniprot.org/uniprot/D6GRC7 ^@ Similarity ^@ Belongs to the UPF0102 family. http://togogenome.org/gene/546269:HMPREF0389_RS06370 ^@ http://purl.uniprot.org/uniprot/D6GQ39 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.|||Belongs to the KhpA RNA-binding protein family.|||Cytoplasm|||Forms a complex with KhpB. http://togogenome.org/gene/546269:HMPREF0389_RS01545 ^@ http://purl.uniprot.org/uniprot/D6GRW8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RimP family.|||Cytoplasm|||Required for maturation of 30S ribosomal subunits. http://togogenome.org/gene/546269:HMPREF0389_RS05760 ^@ http://purl.uniprot.org/uniprot/D6GPR2 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/546269:HMPREF0389_RS00020 ^@ http://purl.uniprot.org/uniprot/D6GSV6 ^@ Similarity ^@ Belongs to the FldB/FldC dehydratase alpha/beta subunit family. http://togogenome.org/gene/546269:HMPREF0389_RS06250 ^@ http://purl.uniprot.org/uniprot/D6GQ13 ^@ Cofactor|||Similarity ^@ Belongs to the PyrK family.|||Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/546269:HMPREF0389_RS05095 ^@ http://purl.uniprot.org/uniprot/D6GU59 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/546269:HMPREF0389_RS00785 ^@ http://purl.uniprot.org/uniprot/D6GSB7 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/546269:HMPREF0389_RS06445 ^@ http://purl.uniprot.org/uniprot/D6GQ53 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/546269:HMPREF0389_RS03730 ^@ http://purl.uniprot.org/uniprot/D6GTZ2 ^@ Function|||Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/546269:HMPREF0389_RS05785 ^@ http://purl.uniprot.org/uniprot/D6GPR8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell membrane|||Cytoplasm|||Monomer. http://togogenome.org/gene/546269:HMPREF0389_RS07770 ^@ http://purl.uniprot.org/uniprot/D6GQX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.|||Cell membrane http://togogenome.org/gene/546269:HMPREF0389_RS00060 ^@ http://purl.uniprot.org/uniprot/D6GSU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecF family.|||Cytoplasm|||The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. http://togogenome.org/gene/546269:HMPREF0389_RS05280 ^@ http://purl.uniprot.org/uniprot/D6GSN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS00425 ^@ http://purl.uniprot.org/uniprot/D6GSI9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/546269:HMPREF0389_RS01585 ^@ http://purl.uniprot.org/uniprot/D6GRW0 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/546269:HMPREF0389_RS07010 ^@ http://purl.uniprot.org/uniprot/D6GQG5 ^@ Similarity ^@ Belongs to the phosphate acetyltransferase and butyryltransferase family. http://togogenome.org/gene/546269:HMPREF0389_RS07935 ^@ http://purl.uniprot.org/uniprot/D6GTA2 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/546269:HMPREF0389_RS04470 ^@ http://purl.uniprot.org/uniprot/D6GTK4 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/546269:HMPREF0389_RS03360 ^@ http://purl.uniprot.org/uniprot/E8RK94 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GdpP/PdeA phosphodiesterase family.|||Cell membrane|||For phosphodiesterase activity, probably binds 2 Mn(2+) per subunit.|||Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP). http://togogenome.org/gene/546269:HMPREF0389_RS07140 ^@ http://purl.uniprot.org/uniprot/D6GQJ2 ^@ Similarity ^@ Belongs to the UPF0297 family. http://togogenome.org/gene/546269:HMPREF0389_RS05980 ^@ http://purl.uniprot.org/uniprot/D6GPW0 ^@ Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||GTPase that plays an essential role in the late steps of ribosome biogenesis. http://togogenome.org/gene/546269:HMPREF0389_RS02795 ^@ http://purl.uniprot.org/uniprot/D6GR73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the auxin efflux carrier (TC 2.A.69) family.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS05310 ^@ http://purl.uniprot.org/uniprot/D6GPH8 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/546269:HMPREF0389_RS06775 ^@ http://purl.uniprot.org/uniprot/D6GQB9 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 9 family. http://togogenome.org/gene/546269:HMPREF0389_RS03220 ^@ http://purl.uniprot.org/uniprot/D6GU70 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/546269:HMPREF0389_RS01480 ^@ http://purl.uniprot.org/uniprot/D6GRY1 ^@ Cofactor|||Similarity ^@ Belongs to the rubredoxin family.|||Binds 1 Fe(3+) ion per subunit. http://togogenome.org/gene/546269:HMPREF0389_RS06470 ^@ http://purl.uniprot.org/uniprot/D6GQ58 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/546269:HMPREF0389_RS06815 ^@ http://purl.uniprot.org/uniprot/D6GQC7 ^@ Similarity ^@ Belongs to the asparaginase 1 family. http://togogenome.org/gene/546269:HMPREF0389_RS00545 ^@ http://purl.uniprot.org/uniprot/D6GSG5 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/546269:HMPREF0389_RS03985 ^@ http://purl.uniprot.org/uniprot/D6GTU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase D family. Cardiolipin synthase subfamily.|||Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS00120 ^@ http://purl.uniprot.org/uniprot/D6GST6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/546269:HMPREF0389_RS07005 ^@ http://purl.uniprot.org/uniprot/D6GQG4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS06000 ^@ http://purl.uniprot.org/uniprot/D6GPW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS01330 ^@ http://purl.uniprot.org/uniprot/D6GS10 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the adenylate cyclase family. DacA/CdaA subfamily.|||Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Probably a homodimer. http://togogenome.org/gene/546269:HMPREF0389_RS06525 ^@ http://purl.uniprot.org/uniprot/D6GQ69 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/546269:HMPREF0389_RS04275 ^@ http://purl.uniprot.org/uniprot/D6GTP2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gmhB family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/546269:HMPREF0389_RS02840 ^@ http://purl.uniprot.org/uniprot/D6GR64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS04200 ^@ http://purl.uniprot.org/uniprot/D6GTQ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase delta chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction. http://togogenome.org/gene/546269:HMPREF0389_RS08450 ^@ http://purl.uniprot.org/uniprot/D6GSZ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6. http://togogenome.org/gene/546269:HMPREF0389_RS02705 ^@ http://purl.uniprot.org/uniprot/D6GR90 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase S24 family.|||Homodimer.|||Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. http://togogenome.org/gene/546269:HMPREF0389_RS02120 ^@ http://purl.uniprot.org/uniprot/D6GRK5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/546269:HMPREF0389_RS01900 ^@ http://purl.uniprot.org/uniprot/D6GRQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS02320 ^@ http://purl.uniprot.org/uniprot/D6GRG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.|||Cell membrane http://togogenome.org/gene/546269:HMPREF0389_RS03720 ^@ http://purl.uniprot.org/uniprot/D6GTZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the arginine deiminase family.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS02050 ^@ http://purl.uniprot.org/uniprot/D6GRM1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS04650 ^@ http://purl.uniprot.org/uniprot/D6GTG7 ^@ Similarity ^@ In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family. http://togogenome.org/gene/546269:HMPREF0389_RS04205 ^@ http://purl.uniprot.org/uniprot/D6GTQ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase B chain family.|||Cell membrane|||Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS07270 ^@ http://purl.uniprot.org/uniprot/D6GQM1 ^@ Similarity ^@ Belongs to the peptidase C69 family. http://togogenome.org/gene/546269:HMPREF0389_RS05590 ^@ http://purl.uniprot.org/uniprot/D6GPM9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS06245 ^@ http://purl.uniprot.org/uniprot/D6GQ12 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS07535 ^@ http://purl.uniprot.org/uniprot/D6GQS4 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/546269:HMPREF0389_RS07220 ^@ http://purl.uniprot.org/uniprot/D6GQK9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SbcD family.|||Heterodimer of SbcC and SbcD.|||SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity. http://togogenome.org/gene/546269:HMPREF0389_RS06990 ^@ http://purl.uniprot.org/uniprot/D6GQG1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccD/PCCB family.|||Binds 1 zinc ion per subunit.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS07625 ^@ http://purl.uniprot.org/uniprot/D6GQU1 ^@ Similarity ^@ Belongs to the YggT family. http://togogenome.org/gene/546269:HMPREF0389_RS04940 ^@ http://purl.uniprot.org/uniprot/D6GTA6 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/546269:HMPREF0389_RS04310 ^@ http://purl.uniprot.org/uniprot/D6GTN6 ^@ Similarity ^@ Belongs to the FldB/FldC dehydratase alpha/beta subunit family. http://togogenome.org/gene/546269:HMPREF0389_RS06360 ^@ http://purl.uniprot.org/uniprot/D6GQ37 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/546269:HMPREF0389_RS02810 ^@ http://purl.uniprot.org/uniprot/D6GR70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS01700 ^@ http://purl.uniprot.org/uniprot/D6GRT6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbsD / FucU family. RbsD subfamily.|||Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.|||Cytoplasm|||Homodecamer. http://togogenome.org/gene/546269:HMPREF0389_RS00960 ^@ http://purl.uniprot.org/uniprot/D6GS83 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/546269:HMPREF0389_RS06140 ^@ http://purl.uniprot.org/uniprot/E8RK92 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/546269:HMPREF0389_RS02645 ^@ http://purl.uniprot.org/uniprot/D6GRA2 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by GTP. Inhibited by UTP.|||Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS02765 ^@ http://purl.uniprot.org/uniprot/D6GR79 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/546269:HMPREF0389_RS00810 ^@ http://purl.uniprot.org/uniprot/D6GSB2 ^@ Function|||Similarity ^@ Belongs to the relA/spoT family.|||In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. http://togogenome.org/gene/546269:HMPREF0389_RS00735 ^@ http://purl.uniprot.org/uniprot/D6GSC8 ^@ Function|||Similarity ^@ Belongs to the peptidase S11 family.|||Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. http://togogenome.org/gene/546269:HMPREF0389_RS04895 ^@ http://purl.uniprot.org/uniprot/D6GTB6 ^@ Similarity ^@ Belongs to the DDAH family. http://togogenome.org/gene/546269:HMPREF0389_RS02605 ^@ http://purl.uniprot.org/uniprot/D6GRB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS08245 ^@ http://purl.uniprot.org/uniprot/D6GT38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS07120 ^@ http://purl.uniprot.org/uniprot/D6GQI8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.|||Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.|||Cytoplasm|||Homodimer, may be a subunit of the RNA degradosome. http://togogenome.org/gene/546269:HMPREF0389_RS08525 ^@ http://purl.uniprot.org/uniprot/D6GSY4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS01630 ^@ http://purl.uniprot.org/uniprot/D6GRV1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS05720 ^@ http://purl.uniprot.org/uniprot/D6GPQ3 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/546269:HMPREF0389_RS06650 ^@ http://purl.uniprot.org/uniprot/D6GQ94 ^@ Similarity ^@ Belongs to the asp23 family. http://togogenome.org/gene/546269:HMPREF0389_RS02565 ^@ http://purl.uniprot.org/uniprot/D6GRB8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.|||Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.|||Homodimer. http://togogenome.org/gene/546269:HMPREF0389_RS02715 ^@ http://purl.uniprot.org/uniprot/D6GR88 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/546269:HMPREF0389_RS05275 ^@ http://purl.uniprot.org/uniprot/D6GSN3 ^@ Similarity ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/546269:HMPREF0389_RS01765 ^@ http://purl.uniprot.org/uniprot/D6GRS3 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.|||Belongs to the peptidase S16 family.|||By heat shock.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity. http://togogenome.org/gene/546269:HMPREF0389_RS08165 ^@ http://purl.uniprot.org/uniprot/D6GT54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS05970 ^@ http://purl.uniprot.org/uniprot/D6GPV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS06385 ^@ http://purl.uniprot.org/uniprot/D6GQ42 ^@ Function|||Similarity ^@ Belongs to the UPF0122 family.|||Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein. http://togogenome.org/gene/546269:HMPREF0389_RS08485 ^@ http://purl.uniprot.org/uniprot/D6GSZ2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/546269:HMPREF0389_RS01335 ^@ http://purl.uniprot.org/uniprot/D6GS09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS00550 ^@ http://purl.uniprot.org/uniprot/D6GSG4 ^@ Similarity ^@ Belongs to the peptidase S41A family. http://togogenome.org/gene/546269:HMPREF0389_RS02730 ^@ http://purl.uniprot.org/uniprot/D6GR85 ^@ Function|||Similarity ^@ Belongs to the HrcA family.|||Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons. http://togogenome.org/gene/546269:HMPREF0389_RS07305 ^@ http://purl.uniprot.org/uniprot/D6GQM8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/546269:HMPREF0389_RS07790 ^@ http://purl.uniprot.org/uniprot/D6GQX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS06040 ^@ http://purl.uniprot.org/uniprot/D6GPX3 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/546269:HMPREF0389_RS03495 ^@ http://purl.uniprot.org/uniprot/D6GU38 ^@ Function|||Similarity ^@ Belongs to the RecD family. RecD-like subfamily.|||DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity. http://togogenome.org/gene/546269:HMPREF0389_RS06960 ^@ http://purl.uniprot.org/uniprot/D6GQF5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.|||Homotetramer. http://togogenome.org/gene/546269:HMPREF0389_RS02540 ^@ http://purl.uniprot.org/uniprot/D6GRC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CodY family.|||Cytoplasm|||DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability. During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion. http://togogenome.org/gene/546269:HMPREF0389_RS02650 ^@ http://purl.uniprot.org/uniprot/D6GRA1 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/546269:HMPREF0389_RS02965 ^@ http://purl.uniprot.org/uniprot/D6GR39 ^@ Cofactor ^@ Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/546269:HMPREF0389_RS00130 ^@ http://purl.uniprot.org/uniprot/D6GST4 ^@ Similarity ^@ In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.|||In the central section; belongs to the CRISPR-associated helicase Cas3 family. http://togogenome.org/gene/546269:HMPREF0389_RS05900 ^@ http://purl.uniprot.org/uniprot/D6GPU1 ^@ Function|||Similarity ^@ Belongs to the NadC/ModD family.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/546269:HMPREF0389_RS00980 ^@ http://purl.uniprot.org/uniprot/E8RK71 ^@ Caution|||Function|||Similarity ^@ Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. http://togogenome.org/gene/546269:HMPREF0389_RS03065 ^@ http://purl.uniprot.org/uniprot/D6GR19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS06580 ^@ http://purl.uniprot.org/uniprot/D6GQ81 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/546269:HMPREF0389_RS07090 ^@ http://purl.uniprot.org/uniprot/D6GQI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS00070 ^@ http://purl.uniprot.org/uniprot/D6GSU6 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/546269:HMPREF0389_RS03705 ^@ http://purl.uniprot.org/uniprot/D6GTZ7 ^@ Similarity ^@ Belongs to the aspartate/glutamate racemases family. http://togogenome.org/gene/546269:HMPREF0389_RS01490 ^@ http://purl.uniprot.org/uniprot/D6GRX9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/546269:HMPREF0389_RS04340 ^@ http://purl.uniprot.org/uniprot/D6GTN0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS04455 ^@ http://purl.uniprot.org/uniprot/D6GTK7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. http://togogenome.org/gene/546269:HMPREF0389_RS02535 ^@ http://purl.uniprot.org/uniprot/D6GRC4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/546269:HMPREF0389_RS02860 ^@ http://purl.uniprot.org/uniprot/D6GR60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YejK family.|||nucleoid http://togogenome.org/gene/546269:HMPREF0389_RS03290 ^@ http://purl.uniprot.org/uniprot/D6GU56 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/546269:HMPREF0389_RS08310 ^@ http://purl.uniprot.org/uniprot/D6GT26 ^@ Function|||Similarity ^@ Belongs to the WhiA family.|||Involved in cell division and chromosome segregation. http://togogenome.org/gene/546269:HMPREF0389_RS04005 ^@ http://purl.uniprot.org/uniprot/D6GTT7 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidine kinase family.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS02935 ^@ http://purl.uniprot.org/uniprot/D6GR45 ^@ Similarity ^@ Belongs to the peptidase M18 family. http://togogenome.org/gene/546269:HMPREF0389_RS00155 ^@ http://purl.uniprot.org/uniprot/D6GSS9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/546269:HMPREF0389_RS01600 ^@ http://purl.uniprot.org/uniprot/D6GRV7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/546269:HMPREF0389_RS06135 ^@ http://purl.uniprot.org/uniprot/D6GPZ0 ^@ Similarity ^@ Belongs to the homoserine dehydrogenase family. http://togogenome.org/gene/546269:HMPREF0389_RS06995 ^@ http://purl.uniprot.org/uniprot/D6GQG2 ^@ Function|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.|||This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/546269:HMPREF0389_RS07615 ^@ http://purl.uniprot.org/uniprot/D6GQT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS03885 ^@ http://purl.uniprot.org/uniprot/D6GTV8 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/546269:HMPREF0389_RS01790 ^@ http://purl.uniprot.org/uniprot/D6GRR7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/546269:HMPREF0389_RS06595 ^@ http://purl.uniprot.org/uniprot/D6GQ83 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/546269:HMPREF0389_RS08400 ^@ http://purl.uniprot.org/uniprot/D6GT10 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable RNA chaperone. Forms a complex with KhpA which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.|||Belongs to the KhpB RNA-binding protein family.|||Cytoplasm|||Forms a complex with KhpA.|||Has an N-terminal Jag-N domain and 2 RNA-binding domains (KH and R3H). http://togogenome.org/gene/546269:HMPREF0389_RS07240 ^@ http://purl.uniprot.org/uniprot/E8RK69 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell membrane|||Cytoplasm|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/546269:HMPREF0389_RS06365 ^@ http://purl.uniprot.org/uniprot/D6GQ38 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.|||Belongs to the RimM family.|||Binds ribosomal protein uS19.|||Cytoplasm|||The PRC barrel domain binds ribosomal protein uS19. http://togogenome.org/gene/546269:HMPREF0389_RS01235 ^@ http://purl.uniprot.org/uniprot/D6GS29 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DNA polymerase type-C family. DnaE subfamily.|||Cytoplasm|||DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase. http://togogenome.org/gene/546269:HMPREF0389_RS03100 ^@ http://purl.uniprot.org/uniprot/D6GR11 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/546269:HMPREF0389_RS01450 ^@ http://purl.uniprot.org/uniprot/D6GRY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS04655 ^@ http://purl.uniprot.org/uniprot/D6GTG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.|||Belongs to the RNR ribonuclease family. RNase R subfamily.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS06560 ^@ http://purl.uniprot.org/uniprot/D6GQ77 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/546269:HMPREF0389_RS03795 ^@ http://purl.uniprot.org/uniprot/D6GTX7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS00350 ^@ http://purl.uniprot.org/uniprot/D6GSP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0126 family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS03050 ^@ http://purl.uniprot.org/uniprot/D6GR22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/546269:HMPREF0389_RS07290 ^@ http://purl.uniprot.org/uniprot/D6GQM5 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/546269:HMPREF0389_RS06505 ^@ http://purl.uniprot.org/uniprot/D6GQ65 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/546269:HMPREF0389_RS03230 ^@ http://purl.uniprot.org/uniprot/D6GU68 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Cytoplasm|||Homodimer.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/546269:HMPREF0389_RS06130 ^@ http://purl.uniprot.org/uniprot/D6GPY9 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/546269:HMPREF0389_RS06095 ^@ http://purl.uniprot.org/uniprot/D6GPY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS00630 ^@ http://purl.uniprot.org/uniprot/D6GSE8 ^@ Function|||Similarity ^@ Belongs to the transglycosylase MltG family.|||Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. http://togogenome.org/gene/546269:HMPREF0389_RS01295 ^@ http://purl.uniprot.org/uniprot/D6GS17 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoD/SigA subfamily.|||Cytoplasm|||Interacts transiently with the RNA polymerase catalytic core.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. http://togogenome.org/gene/546269:HMPREF0389_RS04195 ^@ http://purl.uniprot.org/uniprot/D6GTQ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/546269:HMPREF0389_RS05930 ^@ http://purl.uniprot.org/uniprot/D6GPU7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.|||Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD). http://togogenome.org/gene/546269:HMPREF0389_RS03780 ^@ http://purl.uniprot.org/uniprot/D6GTY0 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. http://togogenome.org/gene/546269:HMPREF0389_RS04685 ^@ http://purl.uniprot.org/uniprot/D6GTG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||Cytoplasm|||Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/546269:HMPREF0389_RS06535 ^@ http://purl.uniprot.org/uniprot/D6GQ71 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/546269:HMPREF0389_RS01145 ^@ http://purl.uniprot.org/uniprot/D6GS47 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/546269:HMPREF0389_RS04910 ^@ http://purl.uniprot.org/uniprot/D6GTB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS03925 ^@ http://purl.uniprot.org/uniprot/D6GTV0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/546269:HMPREF0389_RS05110 ^@ http://purl.uniprot.org/uniprot/E8RKB8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/546269:HMPREF0389_RS06510 ^@ http://purl.uniprot.org/uniprot/D6GQ66 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/546269:HMPREF0389_RS05820 ^@ http://purl.uniprot.org/uniprot/D6GPS5 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/546269:HMPREF0389_RS00395 ^@ http://purl.uniprot.org/uniprot/D6GSJ5 ^@ Function|||Similarity ^@ ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.|||Belongs to the ParA family. MinD subfamily. http://togogenome.org/gene/546269:HMPREF0389_RS06035 ^@ http://purl.uniprot.org/uniprot/D6GPX2 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/546269:HMPREF0389_RS00560 ^@ http://purl.uniprot.org/uniprot/D6GSG2 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/546269:HMPREF0389_RS04105 ^@ http://purl.uniprot.org/uniprot/D6GTR9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.|||Binds 1 zinc ion per subunit.|||Binds the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/546269:HMPREF0389_RS03790 ^@ http://purl.uniprot.org/uniprot/D6GTX8 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.|||Cytoplasm|||Heterotetramer of two alpha and two beta chains.|||Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway. http://togogenome.org/gene/546269:HMPREF0389_RS02850 ^@ http://purl.uniprot.org/uniprot/D6GR62 ^@ Similarity ^@ Belongs to the ycf81 family. http://togogenome.org/gene/546269:HMPREF0389_RS03115 ^@ http://purl.uniprot.org/uniprot/D6GR09 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/546269:HMPREF0389_RS07310 ^@ http://purl.uniprot.org/uniprot/D6GQM9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. PriA subfamily.|||Component of the primosome.|||Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. http://togogenome.org/gene/546269:HMPREF0389_RS07300 ^@ http://purl.uniprot.org/uniprot/D6GQM7 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/546269:HMPREF0389_RS05975 ^@ http://purl.uniprot.org/uniprot/E8RKC7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsY family.|||Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.|||Cell membrane|||Probably interacts with PlsX. http://togogenome.org/gene/546269:HMPREF0389_RS06340 ^@ http://purl.uniprot.org/uniprot/D6GQ32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS01355 ^@ http://purl.uniprot.org/uniprot/D6GS05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/546269:HMPREF0389_RS08145 ^@ http://purl.uniprot.org/uniprot/D6GT58 ^@ Similarity ^@ Belongs to the V-ATPase V0D/AC39 subunit family. http://togogenome.org/gene/546269:HMPREF0389_RS00480 ^@ http://purl.uniprot.org/uniprot/D6GSH8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS08240 ^@ http://purl.uniprot.org/uniprot/D6GT39 ^@ Similarity ^@ Belongs to the UPF0423 family. http://togogenome.org/gene/546269:HMPREF0389_RS06375 ^@ http://purl.uniprot.org/uniprot/D6GQ40 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/546269:HMPREF0389_RS08660 ^@ http://purl.uniprot.org/uniprot/D6GSJ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MinC family.|||Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.|||Interacts with MinD and FtsZ. http://togogenome.org/gene/546269:HMPREF0389_RS07545 ^@ http://purl.uniprot.org/uniprot/D6GQS6 ^@ Similarity ^@ Belongs to the HsdR family. http://togogenome.org/gene/546269:HMPREF0389_RS06790 ^@ http://purl.uniprot.org/uniprot/D6GQC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS06565 ^@ http://purl.uniprot.org/uniprot/D6GQ78 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/546269:HMPREF0389_RS06455 ^@ http://purl.uniprot.org/uniprot/D6GQ55 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/546269:HMPREF0389_RS00590 ^@ http://purl.uniprot.org/uniprot/D6GSF6 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS06935 ^@ http://purl.uniprot.org/uniprot/D6GQF0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family. DXPS subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).|||Homodimer. http://togogenome.org/gene/546269:HMPREF0389_RS06540 ^@ http://purl.uniprot.org/uniprot/D6GQ72 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/546269:HMPREF0389_RS02695 ^@ http://purl.uniprot.org/uniprot/D6GR92 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/546269:HMPREF0389_RS00320 ^@ http://purl.uniprot.org/uniprot/D6GSP7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS02305 ^@ http://purl.uniprot.org/uniprot/D6GRG8 ^@ Similarity ^@ Belongs to the MobA/MobL family. http://togogenome.org/gene/546269:HMPREF0389_RS02560 ^@ http://purl.uniprot.org/uniprot/D6GRB9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ApbE family.|||Cell inner membrane|||Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.|||Magnesium. Can also use manganese. http://togogenome.org/gene/546269:HMPREF0389_RS03880 ^@ http://purl.uniprot.org/uniprot/D6GTV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS08470 ^@ http://purl.uniprot.org/uniprot/D6GSZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS06520 ^@ http://purl.uniprot.org/uniprot/D6GQ68 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/546269:HMPREF0389_RS01495 ^@ http://purl.uniprot.org/uniprot/D6GRX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyribonucleotide nucleotidyltransferase family.|||Cytoplasm|||Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. http://togogenome.org/gene/546269:HMPREF0389_RS00400 ^@ http://purl.uniprot.org/uniprot/D6GSJ4 ^@ Function|||Similarity ^@ Belongs to the MinE family.|||Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. http://togogenome.org/gene/546269:HMPREF0389_RS01170 ^@ http://purl.uniprot.org/uniprot/D6GS42 ^@ Similarity ^@ Belongs to the UPF0237 family. http://togogenome.org/gene/546269:HMPREF0389_RS07865 ^@ http://purl.uniprot.org/uniprot/D6GQY5 ^@ Function|||Similarity ^@ Belongs to the dihydrofolate reductase family.|||Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. http://togogenome.org/gene/546269:HMPREF0389_RS06460 ^@ http://purl.uniprot.org/uniprot/D6GQ56 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/546269:HMPREF0389_RS08125 ^@ http://purl.uniprot.org/uniprot/D6GT62 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/546269:HMPREF0389_RS04460 ^@ http://purl.uniprot.org/uniprot/D6GTK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acetylates the N-terminal alanine of ribosomal protein bS18.|||Belongs to the acetyltransferase family. RimI subfamily.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS03655 ^@ http://purl.uniprot.org/uniprot/D6GU06 ^@ Cofactor|||Similarity ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer. http://togogenome.org/gene/546269:HMPREF0389_RS07115 ^@ http://purl.uniprot.org/uniprot/D6GQI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS04390 ^@ http://purl.uniprot.org/uniprot/D6GTM0 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS06160 ^@ http://purl.uniprot.org/uniprot/E8RKD2 ^@ Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. http://togogenome.org/gene/546269:HMPREF0389_RS01485 ^@ http://purl.uniprot.org/uniprot/D6GRY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS04610 ^@ http://purl.uniprot.org/uniprot/D6GTH5 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/546269:HMPREF0389_RS05160 ^@ http://purl.uniprot.org/uniprot/D6GSL0 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the glutaminase family.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS01015 ^@ http://purl.uniprot.org/uniprot/D6GS74 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/546269:HMPREF0389_RS07415 ^@ http://purl.uniprot.org/uniprot/D6GQQ2 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/546269:HMPREF0389_RS01595 ^@ http://purl.uniprot.org/uniprot/D6GRV8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NrdR family.|||Binds 1 zinc ion.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/546269:HMPREF0389_RS01965 ^@ http://purl.uniprot.org/uniprot/D6GRN7 ^@ Similarity ^@ Belongs to the RelB/DinJ antitoxin family. http://togogenome.org/gene/546269:HMPREF0389_RS06575 ^@ http://purl.uniprot.org/uniprot/D6GQ80 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/546269:HMPREF0389_RS03315 ^@ http://purl.uniprot.org/uniprot/D6GU51 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS01910 ^@ http://purl.uniprot.org/uniprot/D6GRP8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS03995 ^@ http://purl.uniprot.org/uniprot/E8RKA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the auxin efflux carrier (TC 2.A.69) family.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS00805 ^@ http://purl.uniprot.org/uniprot/D6GSB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/546269:HMPREF0389_RS05085 ^@ http://purl.uniprot.org/uniprot/D6GU61 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS04375 ^@ http://purl.uniprot.org/uniprot/D6GTM3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Cell membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS07590 ^@ http://purl.uniprot.org/uniprot/D6GQT5 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Homodimer. http://togogenome.org/gene/546269:HMPREF0389_RS00485 ^@ http://purl.uniprot.org/uniprot/D6GSH7 ^@ Similarity ^@ Belongs to the carbamate kinase family. http://togogenome.org/gene/546269:HMPREF0389_RS04380 ^@ http://purl.uniprot.org/uniprot/D6GTM2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS01625 ^@ http://purl.uniprot.org/uniprot/D6GRV2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family. MurG subfamily.|||Cell membrane|||Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS00710 ^@ http://purl.uniprot.org/uniprot/D6GSD1 ^@ Cofactor|||Similarity ^@ Belongs to the Fur family.|||Binds 1 Mn(2+) or Fe(2+) ion per subunit.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/546269:HMPREF0389_RS01525 ^@ http://purl.uniprot.org/uniprot/D6GRX2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/546269:HMPREF0389_RS04395 ^@ http://purl.uniprot.org/uniprot/D6GTL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nlpA lipoprotein family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS02380 ^@ http://purl.uniprot.org/uniprot/D6GRF3 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/546269:HMPREF0389_RS02910 ^@ http://purl.uniprot.org/uniprot/D6GR50 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 9 family. http://togogenome.org/gene/546269:HMPREF0389_RS03680 ^@ http://purl.uniprot.org/uniprot/D6GU01 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS01725 ^@ http://purl.uniprot.org/uniprot/D6GRT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS01760 ^@ http://purl.uniprot.org/uniprot/D6GRS4 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/546269:HMPREF0389_RS07955 ^@ http://purl.uniprot.org/uniprot/D6GT98 ^@ Subcellular Location Annotation ^@ cell wall http://togogenome.org/gene/546269:HMPREF0389_RS01205 ^@ http://purl.uniprot.org/uniprot/D6GS35 ^@ Cofactor|||Similarity ^@ Belongs to the Fur family.|||Binds 1 Mn(2+) or Fe(2+) ion per subunit.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/546269:HMPREF0389_RS08060 ^@ http://purl.uniprot.org/uniprot/D6GT75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.|||Cytoplasm|||Interacts with 100S ribosomes.|||Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. http://togogenome.org/gene/546269:HMPREF0389_RS07025 ^@ http://purl.uniprot.org/uniprot/D6GQG8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/546269:HMPREF0389_RS08130 ^@ http://purl.uniprot.org/uniprot/D6GT61 ^@ Similarity ^@ Belongs to the V-ATPase F subunit family. http://togogenome.org/gene/546269:HMPREF0389_RS00015 ^@ http://purl.uniprot.org/uniprot/D6GSV7 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/546269:HMPREF0389_RS01615 ^@ http://purl.uniprot.org/uniprot/D6GRV4 ^@ Similarity ^@ Belongs to the UPF0749 family. http://togogenome.org/gene/546269:HMPREF0389_RS00620 ^@ http://purl.uniprot.org/uniprot/D6GSF0 ^@ Function|||Similarity ^@ Belongs to the RecN family.|||May be involved in recombinational repair of damaged DNA. http://togogenome.org/gene/546269:HMPREF0389_RS06620 ^@ http://purl.uniprot.org/uniprot/D6GQ88 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TmcAL family.|||Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS02365 ^@ http://purl.uniprot.org/uniprot/D6GRF6 ^@ Similarity ^@ Belongs to the MobA/MobL family. http://togogenome.org/gene/546269:HMPREF0389_RS01000 ^@ http://purl.uniprot.org/uniprot/D6GS77 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. http://togogenome.org/gene/546269:HMPREF0389_RS00825 ^@ http://purl.uniprot.org/uniprot/D6GSA9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.|||Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS06120 ^@ http://purl.uniprot.org/uniprot/D6GPY7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily.|||Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS02545 ^@ http://purl.uniprot.org/uniprot/D6GRC2 ^@ Similarity ^@ Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. http://togogenome.org/gene/546269:HMPREF0389_RS03575 ^@ http://purl.uniprot.org/uniprot/D6GU22 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dethiobiotin synthetase family.|||Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS03870 ^@ http://purl.uniprot.org/uniprot/D6GTW1 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/546269:HMPREF0389_RS01405 ^@ http://purl.uniprot.org/uniprot/D6GRZ5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS06980 ^@ http://purl.uniprot.org/uniprot/D6GQF9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/546269:HMPREF0389_RS08595 ^@ http://purl.uniprot.org/uniprot/D6GSX0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MnmG family.|||Cytoplasm|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. http://togogenome.org/gene/546269:HMPREF0389_RS06545 ^@ http://purl.uniprot.org/uniprot/D6GQ73 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/546269:HMPREF0389_RS05055 ^@ http://purl.uniprot.org/uniprot/D6GU67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0324 family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS07710 ^@ http://purl.uniprot.org/uniprot/D6GQV6 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/546269:HMPREF0389_RS06950 ^@ http://purl.uniprot.org/uniprot/D6GQF3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thioester dehydratase family. FabZ subfamily.|||Cytoplasm|||Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. http://togogenome.org/gene/546269:HMPREF0389_RS03905 ^@ http://purl.uniprot.org/uniprot/D6GTV4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/546269:HMPREF0389_RS05990 ^@ http://purl.uniprot.org/uniprot/D6GPW2 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/546269:HMPREF0389_RS00005 ^@ http://purl.uniprot.org/uniprot/D6GSV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DnaA family.|||Cytoplasm|||Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. http://togogenome.org/gene/546269:HMPREF0389_RS02900 ^@ http://purl.uniprot.org/uniprot/D6GR52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS02250 ^@ http://purl.uniprot.org/uniprot/D6GRH9 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily. http://togogenome.org/gene/546269:HMPREF0389_RS04410 ^@ http://purl.uniprot.org/uniprot/D6GTL6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS01800 ^@ http://purl.uniprot.org/uniprot/D6GRR5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. http://togogenome.org/gene/546269:HMPREF0389_RS08305 ^@ http://purl.uniprot.org/uniprot/D6GT27 ^@ Function ^@ General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. http://togogenome.org/gene/546269:HMPREF0389_RS00515 ^@ http://purl.uniprot.org/uniprot/D6GSH1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.|||Belongs to the AAA ATPase family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Homohexamer.|||In the C-terminal section; belongs to the peptidase M41 family.|||In the central section; belongs to the AAA ATPase family. http://togogenome.org/gene/546269:HMPREF0389_RS06905 ^@ http://purl.uniprot.org/uniprot/D6GQE4 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/546269:HMPREF0389_RS06805 ^@ http://purl.uniprot.org/uniprot/D6GQC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.|||Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.|||Cell membrane|||Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS01370 ^@ http://purl.uniprot.org/uniprot/D6GS02 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/546269:HMPREF0389_RS04495 ^@ http://purl.uniprot.org/uniprot/D6GTJ9 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/546269:HMPREF0389_RS06255 ^@ http://purl.uniprot.org/uniprot/D6GQ14 ^@ Similarity ^@ Belongs to the OMP decarboxylase family. Type 2 subfamily. http://togogenome.org/gene/546269:HMPREF0389_RS06495 ^@ http://purl.uniprot.org/uniprot/D6GQ63 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/546269:HMPREF0389_RS07595 ^@ http://purl.uniprot.org/uniprot/D6GQT6 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/546269:HMPREF0389_RS08155 ^@ http://purl.uniprot.org/uniprot/D6GT56 ^@ Caution|||Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Belongs to the MsrB Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS03310 ^@ http://purl.uniprot.org/uniprot/D6GU52 ^@ Domain|||Function|||Similarity ^@ Belongs to the RecA family. RadA subfamily.|||DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.|||Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.|||The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. http://togogenome.org/gene/546269:HMPREF0389_RS04820 ^@ http://purl.uniprot.org/uniprot/D6GTD1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 90 family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Molecular chaperone. Has ATPase activity. http://togogenome.org/gene/546269:HMPREF0389_RS06060 ^@ http://purl.uniprot.org/uniprot/D6GPX7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/546269:HMPREF0389_RS00355 ^@ http://purl.uniprot.org/uniprot/D6GSP0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS05945 ^@ http://purl.uniprot.org/uniprot/D6GPV1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ClpA/ClpB family.|||Cytoplasm|||Homohexamer. The oligomerization is ATP-dependent.|||Homohexamer; The oligomerization is ATP-dependent.|||Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. http://togogenome.org/gene/546269:HMPREF0389_RS05260 ^@ http://purl.uniprot.org/uniprot/D6GSN0 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/546269:HMPREF0389_RS08340 ^@ http://purl.uniprot.org/uniprot/D6GT20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0182 family.|||Cell membrane http://togogenome.org/gene/546269:HMPREF0389_RS01500 ^@ http://purl.uniprot.org/uniprot/D6GRX7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/546269:HMPREF0389_RS08600 ^@ http://purl.uniprot.org/uniprot/D6GSW9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the N7 position of a guanine in 16S rRNA. http://togogenome.org/gene/546269:HMPREF0389_RS01785 ^@ http://purl.uniprot.org/uniprot/D6GRR8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.|||Cytoplasm|||In the C-terminal section; belongs to the helicase family. RecG subfamily.|||In the N-terminal section; belongs to the UvrB family. http://togogenome.org/gene/546269:HMPREF0389_RS00415 ^@ http://purl.uniprot.org/uniprot/D6GSJ1 ^@ Function|||Similarity ^@ Belongs to the flavodoxin family.|||Low-potential electron donor to a number of redox enzymes. http://togogenome.org/gene/546269:HMPREF0389_RS02495 ^@ http://purl.uniprot.org/uniprot/D6GRD3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS08670 ^@ http://purl.uniprot.org/uniprot/D6GS96 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/546269:HMPREF0389_RS02660 ^@ http://purl.uniprot.org/uniprot/D6GR99 ^@ Similarity ^@ Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. http://togogenome.org/gene/546269:HMPREF0389_RS08140 ^@ http://purl.uniprot.org/uniprot/D6GT59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS01305 ^@ http://purl.uniprot.org/uniprot/D6GS15 ^@ Similarity ^@ Belongs to the UPF0735 family. http://togogenome.org/gene/546269:HMPREF0389_RS00160 ^@ http://purl.uniprot.org/uniprot/D6GSS8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/546269:HMPREF0389_RS05830 ^@ http://purl.uniprot.org/uniprot/D6GPS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.|||Cytoplasm|||Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity. http://togogenome.org/gene/546269:HMPREF0389_RS01135 ^@ http://purl.uniprot.org/uniprot/D6GS49 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecX family.|||Cytoplasm|||Modulates RecA activity. http://togogenome.org/gene/546269:HMPREF0389_RS01005 ^@ http://purl.uniprot.org/uniprot/D6GS76 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/546269:HMPREF0389_RS02455 ^@ http://purl.uniprot.org/uniprot/D6GRE0 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/546269:HMPREF0389_RS01430 ^@ http://purl.uniprot.org/uniprot/D6GRZ1 ^@ Function|||Similarity ^@ Belongs to the alanine racemase family.|||Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. http://togogenome.org/gene/546269:HMPREF0389_RS08580 ^@ http://purl.uniprot.org/uniprot/D6GSX3 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS00895 ^@ http://purl.uniprot.org/uniprot/D6GS95 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/546269:HMPREF0389_RS02330 ^@ http://purl.uniprot.org/uniprot/D6GRG3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS00085 ^@ http://purl.uniprot.org/uniprot/D6GSU3 ^@ Similarity ^@ Belongs to the anti-sigma-factor antagonist family. http://togogenome.org/gene/546269:HMPREF0389_RS00625 ^@ http://purl.uniprot.org/uniprot/D6GSE9 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/546269:HMPREF0389_RS03095 ^@ http://purl.uniprot.org/uniprot/D6GR12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS00605 ^@ http://purl.uniprot.org/uniprot/D6GSF3 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/546269:HMPREF0389_RS06515 ^@ http://purl.uniprot.org/uniprot/D6GQ67 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/546269:HMPREF0389_RS01280 ^@ http://purl.uniprot.org/uniprot/D6GS20 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/546269:HMPREF0389_RS02165 ^@ http://purl.uniprot.org/uniprot/D6GRJ6 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/546269:HMPREF0389_RS03265 ^@ http://purl.uniprot.org/uniprot/D6GU61 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS08815 ^@ http://purl.uniprot.org/uniprot/E8RK80 ^@ Subcellular Location Annotation ^@ cell wall http://togogenome.org/gene/546269:HMPREF0389_RS08795 ^@ http://purl.uniprot.org/uniprot/D6GQL2 ^@ Similarity ^@ Belongs to the LytR/CpsA/Psr (LCP) family. http://togogenome.org/gene/546269:HMPREF0389_RS06030 ^@ http://purl.uniprot.org/uniprot/D6GPX1 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/546269:HMPREF0389_RS02780 ^@ http://purl.uniprot.org/uniprot/D6GR76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS08445 ^@ http://purl.uniprot.org/uniprot/D6GT00 ^@ Caution|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS00920 ^@ http://purl.uniprot.org/uniprot/D6GS90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS01610 ^@ http://purl.uniprot.org/uniprot/D6GRV5 ^@ Similarity ^@ Belongs to the UPF0749 family. http://togogenome.org/gene/546269:HMPREF0389_RS00405 ^@ http://purl.uniprot.org/uniprot/D6GSJ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS01795 ^@ http://purl.uniprot.org/uniprot/D6GRR6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MrnC RNase family.|||Cytoplasm|||Homodimer.|||Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors. http://togogenome.org/gene/546269:HMPREF0389_RS00800 ^@ http://purl.uniprot.org/uniprot/D6GSB4 ^@ Similarity ^@ Belongs to the RecJ family. http://togogenome.org/gene/546269:HMPREF0389_RS05215 ^@ http://purl.uniprot.org/uniprot/D6GSM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0053 family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS08410 ^@ http://purl.uniprot.org/uniprot/D6GT08 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.|||Binds 1 potassium ion per subunit.|||Cytoplasm|||Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS05150 ^@ http://purl.uniprot.org/uniprot/D6GSK8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/546269:HMPREF0389_RS05185 ^@ http://purl.uniprot.org/uniprot/D6GSL5 ^@ Similarity ^@ Belongs to the peptidase S66 family. http://togogenome.org/gene/546269:HMPREF0389_RS06600 ^@ http://purl.uniprot.org/uniprot/D6GQ84 ^@ Similarity ^@ In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/546269:HMPREF0389_RS08645 ^@ http://purl.uniprot.org/uniprot/D6GSW1 ^@ Similarity ^@ Belongs to the peptidase S58 family. http://togogenome.org/gene/546269:HMPREF0389_RS05895 ^@ http://purl.uniprot.org/uniprot/D6GPU0 ^@ Function|||Miscellaneous|||Similarity ^@ Belongs to the L-aspartate dehydrogenase family.|||Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.|||The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia. http://togogenome.org/gene/546269:HMPREF0389_RS01520 ^@ http://purl.uniprot.org/uniprot/D6GRX3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/546269:HMPREF0389_RS05635 ^@ http://purl.uniprot.org/uniprot/D6GPN8 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/546269:HMPREF0389_RS06475 ^@ http://purl.uniprot.org/uniprot/D6GQ59 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/546269:HMPREF0389_RS00580 ^@ http://purl.uniprot.org/uniprot/D6GSF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ribonuclease M5 family.|||Cytoplasm|||Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step. http://togogenome.org/gene/546269:HMPREF0389_RS02990 ^@ http://purl.uniprot.org/uniprot/D6GR34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS04190 ^@ http://purl.uniprot.org/uniprot/D6GTQ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase gamma chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. http://togogenome.org/gene/546269:HMPREF0389_RS05330 ^@ http://purl.uniprot.org/uniprot/D6GPI2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS08390 ^@ http://purl.uniprot.org/uniprot/D6GT12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0161 family.|||Cell membrane|||Could be involved in insertion of integral membrane proteins into the membrane. http://togogenome.org/gene/546269:HMPREF0389_RS04875 ^@ http://purl.uniprot.org/uniprot/D6GTC0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M17 family.|||Binds 2 manganese ions per subunit.|||Cytoplasm|||Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. http://togogenome.org/gene/546269:HMPREF0389_RS03090 ^@ http://purl.uniprot.org/uniprot/E8RK92 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/546269:HMPREF0389_RS06115 ^@ http://purl.uniprot.org/uniprot/D6GPY6 ^@ Function|||Similarity ^@ Belongs to the aspartokinase family.|||Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine. http://togogenome.org/gene/546269:HMPREF0389_RS05255 ^@ http://purl.uniprot.org/uniprot/D6GSM9 ^@ Caution|||Function|||Similarity ^@ Belongs to the thymidylate kinase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. http://togogenome.org/gene/546269:HMPREF0389_RS07275 ^@ http://purl.uniprot.org/uniprot/D6GQM2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.|||Cell membrane|||Membrane|||Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. http://togogenome.org/gene/546269:HMPREF0389_RS05780 ^@ http://purl.uniprot.org/uniprot/D6GPR7 ^@ Function|||Similarity ^@ Belongs to the RecO family.|||Involved in DNA repair and RecF pathway recombination. http://togogenome.org/gene/546269:HMPREF0389_RS07845 ^@ http://purl.uniprot.org/uniprot/D6GQY1 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. Ycf16 family. http://togogenome.org/gene/546269:HMPREF0389_RS01985 ^@ http://purl.uniprot.org/uniprot/D6GRN3 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/546269:HMPREF0389_RS02875 ^@ http://purl.uniprot.org/uniprot/D6GR57 ^@ Similarity ^@ Belongs to the YicC/YloC family. http://togogenome.org/gene/546269:HMPREF0389_RS02950 ^@ http://purl.uniprot.org/uniprot/D6GR42 ^@ Function|||Similarity ^@ ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. http://togogenome.org/gene/546269:HMPREF0389_RS02970 ^@ http://purl.uniprot.org/uniprot/D6GR38 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/546269:HMPREF0389_RS02740 ^@ http://purl.uniprot.org/uniprot/E8RK89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/546269:HMPREF0389_RS07050 ^@ http://purl.uniprot.org/uniprot/D6GQH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/546269:HMPREF0389_RS04670 ^@ http://purl.uniprot.org/uniprot/D6GTG3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the flotillin-like FloA family.|||Cell membrane|||Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.|||Homooligomerizes.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane raft http://togogenome.org/gene/546269:HMPREF0389_RS02485 ^@ http://purl.uniprot.org/uniprot/D6GRD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GDT1 family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS05620 ^@ http://purl.uniprot.org/uniprot/D6GPN5 ^@ Similarity ^@ Belongs to the type IA topoisomerase family. http://togogenome.org/gene/546269:HMPREF0389_RS01110 ^@ http://purl.uniprot.org/uniprot/D6GS54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A24 family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS06440 ^@ http://purl.uniprot.org/uniprot/D6GQ52 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/546269:HMPREF0389_RS06315 ^@ http://purl.uniprot.org/uniprot/D6GQ27 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/546269:HMPREF0389_RS06240 ^@ http://purl.uniprot.org/uniprot/D6GQ11 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS04730 ^@ http://purl.uniprot.org/uniprot/D6GTF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.|||Cell membrane|||Membrane|||Probable transporter of a GTP-driven Fe(2+) uptake system. http://togogenome.org/gene/546269:HMPREF0389_RS02825 ^@ http://purl.uniprot.org/uniprot/D6GR67 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/546269:HMPREF0389_RS05205 ^@ http://purl.uniprot.org/uniprot/D6GSL9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Mg(2+) ion per subunit.|||Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.|||Cytoplasm|||Homotrimer.|||In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/546269:HMPREF0389_RS01640 ^@ http://purl.uniprot.org/uniprot/D6GRU9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. MraY subfamily.|||Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS04890 ^@ http://purl.uniprot.org/uniprot/D6GTB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS06865 ^@ http://purl.uniprot.org/uniprot/D6GQD7 ^@ Similarity ^@ Belongs to the acetyl-CoA hydrolase/transferase family. http://togogenome.org/gene/546269:HMPREF0389_RS01410 ^@ http://purl.uniprot.org/uniprot/D6GRZ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS03235 ^@ http://purl.uniprot.org/uniprot/D6GU67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0324 family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS07895 ^@ http://purl.uniprot.org/uniprot/D6GQZ1 ^@ Similarity ^@ Belongs to the UPF0473 family. http://togogenome.org/gene/546269:HMPREF0389_RS00985 ^@ http://purl.uniprot.org/uniprot/D6GS80 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/546269:HMPREF0389_RS03810 ^@ http://purl.uniprot.org/uniprot/D6GTX4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS02920 ^@ http://purl.uniprot.org/uniprot/D6GR48 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane|||This protein catalyzes the committed step to the synthesis of the acidic phospholipids. http://togogenome.org/gene/546269:HMPREF0389_RS00745 ^@ http://purl.uniprot.org/uniprot/D6GSC6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/546269:HMPREF0389_RS07755 ^@ http://purl.uniprot.org/uniprot/D6GQW6 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/546269:HMPREF0389_RS00370 ^@ http://purl.uniprot.org/uniprot/D6GSK0 ^@ Similarity ^@ Belongs to the UPF0758 family. http://togogenome.org/gene/546269:HMPREF0389_RS02855 ^@ http://purl.uniprot.org/uniprot/D6GR61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS06965 ^@ http://purl.uniprot.org/uniprot/D6GQF6 ^@ Similarity ^@ Belongs to the fabD family. http://togogenome.org/gene/546269:HMPREF0389_RS00995 ^@ http://purl.uniprot.org/uniprot/D6GS78 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/546269:HMPREF0389_RS08555 ^@ http://purl.uniprot.org/uniprot/D6GSX8 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/546269:HMPREF0389_RS00675 ^@ http://purl.uniprot.org/uniprot/D6GSD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS07850 ^@ http://purl.uniprot.org/uniprot/D6GQY2 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/546269:HMPREF0389_RS03010 ^@ http://purl.uniprot.org/uniprot/D6GR30 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/546269:HMPREF0389_RS02680 ^@ http://purl.uniprot.org/uniprot/D6GR95 ^@ Function|||Similarity ^@ Belongs to the aspartate/glutamate racemases family.|||Provides the (R)-glutamate required for cell wall biosynthesis. http://togogenome.org/gene/546269:HMPREF0389_RS04315 ^@ http://purl.uniprot.org/uniprot/D6GTN5 ^@ Similarity ^@ Belongs to the FldB/FldC dehydratase alpha/beta subunit family. http://togogenome.org/gene/546269:HMPREF0389_RS08135 ^@ http://purl.uniprot.org/uniprot/D6GT60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS00935 ^@ http://purl.uniprot.org/uniprot/D6GS88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS03610 ^@ http://purl.uniprot.org/uniprot/D6GU15 ^@ Similarity ^@ Belongs to the formate--tetrahydrofolate ligase family. http://togogenome.org/gene/546269:HMPREF0389_RS06760 ^@ http://purl.uniprot.org/uniprot/D6GQB6 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/546269:HMPREF0389_RS05235 ^@ http://purl.uniprot.org/uniprot/D6GSM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmI family.|||Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS00270 ^@ http://purl.uniprot.org/uniprot/D6GSQ6 ^@ Similarity ^@ Belongs to the EamA transporter family. http://togogenome.org/gene/546269:HMPREF0389_RS00645 ^@ http://purl.uniprot.org/uniprot/D6GSE5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase Y family.|||Cell membrane|||Endoribonuclease that initiates mRNA decay. http://togogenome.org/gene/546269:HMPREF0389_RS00430 ^@ http://purl.uniprot.org/uniprot/D6GSI8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/546269:HMPREF0389_RS06345 ^@ http://purl.uniprot.org/uniprot/D6GQ33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS07480 ^@ http://purl.uniprot.org/uniprot/D6GQR5 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/546269:HMPREF0389_RS00775 ^@ http://purl.uniprot.org/uniprot/D6GSC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS01180 ^@ http://purl.uniprot.org/uniprot/D6GS40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS05835 ^@ http://purl.uniprot.org/uniprot/D6GPS8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MscL family.|||Cell membrane|||Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.|||Homopentamer.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS04365 ^@ http://purl.uniprot.org/uniprot/D6GTM5 ^@ Similarity ^@ In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family. http://togogenome.org/gene/546269:HMPREF0389_RS01715 ^@ http://purl.uniprot.org/uniprot/D6GRT3 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/546269:HMPREF0389_RS00380 ^@ http://purl.uniprot.org/uniprot/D6GSJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MreD family.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS03590 ^@ http://purl.uniprot.org/uniprot/D6GU19 ^@ Similarity ^@ Belongs to the iron-sulfur dependent L-serine dehydratase family. http://togogenome.org/gene/546269:HMPREF0389_RS00595 ^@ http://purl.uniprot.org/uniprot/D6GSF5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseA family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/546269:HMPREF0389_RS02930 ^@ http://purl.uniprot.org/uniprot/D6GR46 ^@ Similarity ^@ Belongs to the FtsK/SpoIIIE/SftA family. http://togogenome.org/gene/546269:HMPREF0389_RS01320 ^@ http://purl.uniprot.org/uniprot/D6GS12 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. http://togogenome.org/gene/546269:HMPREF0389_RS06885 ^@ http://purl.uniprot.org/uniprot/D6GQE1 ^@ Function|||Similarity ^@ Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.|||Belongs to the organic radical-activating enzymes family. http://togogenome.org/gene/546269:HMPREF0389_RS02460 ^@ http://purl.uniprot.org/uniprot/D6GRD9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A monovalent cation. Ammonium or potassium.|||Belongs to the type III pantothenate kinase family.|||Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/546269:HMPREF0389_RS08625 ^@ http://purl.uniprot.org/uniprot/D6GSW4 ^@ Similarity ^@ Belongs to the sulfur carrier protein TusA family. http://togogenome.org/gene/546269:HMPREF0389_RS04505 ^@ http://purl.uniprot.org/uniprot/D6GTJ7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DnaX/STICHEL family.|||DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/546269:HMPREF0389_RS07020 ^@ http://purl.uniprot.org/uniprot/D6GQG7 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/546269:HMPREF0389_RS01125 ^@ http://purl.uniprot.org/uniprot/D6GS51 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/546269:HMPREF0389_RS01245 ^@ http://purl.uniprot.org/uniprot/D6GS27 ^@ Function ^@ May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/546269:HMPREF0389_RS04500 ^@ http://purl.uniprot.org/uniprot/D6GTJ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YbaB/EbfC family.|||Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.|||Homodimer.|||nucleoid http://togogenome.org/gene/546269:HMPREF0389_RS00945 ^@ http://purl.uniprot.org/uniprot/D6GS86 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RlmN family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.|||Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. http://togogenome.org/gene/546269:HMPREF0389_RS00510 ^@ http://purl.uniprot.org/uniprot/D6GSH2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA(Ile)-lysidine synthase family.|||Cytoplasm|||Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.|||The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding. http://togogenome.org/gene/546269:HMPREF0389_RS07635 ^@ http://purl.uniprot.org/uniprot/D6GQU3 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. http://togogenome.org/gene/546269:HMPREF0389_RS01810 ^@ http://purl.uniprot.org/uniprot/D6GRR3 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS04240 ^@ http://purl.uniprot.org/uniprot/D6GTP9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvC family.|||Binds 2 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA. http://togogenome.org/gene/546269:HMPREF0389_RS04415 ^@ http://purl.uniprot.org/uniprot/D6GTL5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS07565 ^@ http://purl.uniprot.org/uniprot/D6GQT0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS06940 ^@ http://purl.uniprot.org/uniprot/D6GQF1 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/546269:HMPREF0389_RS00965 ^@ http://purl.uniprot.org/uniprot/D6GS82 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit.|||Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. http://togogenome.org/gene/546269:HMPREF0389_RS05740 ^@ http://purl.uniprot.org/uniprot/D6GPQ7 ^@ Similarity ^@ Belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/546269:HMPREF0389_RS08250 ^@ http://purl.uniprot.org/uniprot/D6GT37 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS04745 ^@ http://purl.uniprot.org/uniprot/D6GTE7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS00845 ^@ http://purl.uniprot.org/uniprot/D6GSA6 ^@ Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family. http://togogenome.org/gene/546269:HMPREF0389_RS01455 ^@ http://purl.uniprot.org/uniprot/D6GRY6 ^@ Function|||Similarity ^@ Belongs to the NadD family.|||Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). http://togogenome.org/gene/546269:HMPREF0389_RS01690 ^@ http://purl.uniprot.org/uniprot/D6GRT8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS05130 ^@ http://purl.uniprot.org/uniprot/D6GSK4 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.|||Cell membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Requires K(+) for maximal activity.|||Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane. http://togogenome.org/gene/546269:HMPREF0389_RS07060 ^@ http://purl.uniprot.org/uniprot/D6GQH5 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS04520 ^@ http://purl.uniprot.org/uniprot/D6GTJ4 ^@ Similarity ^@ Belongs to the UPF0145 family. http://togogenome.org/gene/546269:HMPREF0389_RS00990 ^@ http://purl.uniprot.org/uniprot/D6GS79 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUA5 family.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/546269:HMPREF0389_RS02760 ^@ http://purl.uniprot.org/uniprot/D6GR80 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/546269:HMPREF0389_RS06660 ^@ http://purl.uniprot.org/uniprot/D6GQ96 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/546269:HMPREF0389_RS01960 ^@ http://purl.uniprot.org/uniprot/D6GRN9 ^@ Similarity ^@ Belongs to the UPF0758 family. http://togogenome.org/gene/546269:HMPREF0389_RS07455 ^@ http://purl.uniprot.org/uniprot/D6GQR0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/546269:HMPREF0389_RS05175 ^@ http://purl.uniprot.org/uniprot/D6GSL3 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. http://togogenome.org/gene/546269:HMPREF0389_RS00500 ^@ http://purl.uniprot.org/uniprot/D6GSH4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the D-alanine--D-alanine ligase family.|||Binds 2 magnesium or manganese ions per subunit.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/546269:HMPREF0389_RS05925 ^@ http://purl.uniprot.org/uniprot/D6GPU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/546269:HMPREF0389_RS02610 ^@ http://purl.uniprot.org/uniprot/D6GRA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-C family. PolC subfamily.|||Cytoplasm|||Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/546269:HMPREF0389_RS06485 ^@ http://purl.uniprot.org/uniprot/D6GQ61 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit.