http://togogenome.org/gene/575540:ISOP_RS20545 ^@ http://purl.uniprot.org/uniprot/E8R3K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial diacylglycerol kinase family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS23275 ^@ http://purl.uniprot.org/uniprot/E8QYR1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.|||Belongs to the CsrA/RsmA family.|||Cytoplasm|||Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core. http://togogenome.org/gene/575540:ISOP_RS00570 ^@ http://purl.uniprot.org/uniprot/E8R5G4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/575540:ISOP_RS07935 ^@ http://purl.uniprot.org/uniprot/E8QYT5 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/575540:ISOP_RS11570 ^@ http://purl.uniprot.org/uniprot/E8R4C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRISPR system Cmr5 family.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS00875 ^@ http://purl.uniprot.org/uniprot/E8R658 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GtrA family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS03505 ^@ http://purl.uniprot.org/uniprot/E8R0R7 ^@ Similarity ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. http://togogenome.org/gene/575540:ISOP_RS06540 ^@ http://purl.uniprot.org/uniprot/E8R6B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS15640 ^@ http://purl.uniprot.org/uniprot/E8R264 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS20255 ^@ http://purl.uniprot.org/uniprot/E8R637 ^@ Similarity ^@ Belongs to the peptidase A24 family. http://togogenome.org/gene/575540:ISOP_RS05610 ^@ http://purl.uniprot.org/uniprot/E8R458 ^@ Similarity ^@ Belongs to the formate--tetrahydrofolate ligase family. http://togogenome.org/gene/575540:ISOP_RS12025 ^@ http://purl.uniprot.org/uniprot/E8R5Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/575540:ISOP_RS03125 ^@ http://purl.uniprot.org/uniprot/E8R060 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/575540:ISOP_RS15385 ^@ http://purl.uniprot.org/uniprot/E8R1M9 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/575540:ISOP_RS20935 ^@ http://purl.uniprot.org/uniprot/E8R2K2 ^@ Similarity ^@ Belongs to the DNA polymerase type-A family. http://togogenome.org/gene/575540:ISOP_RS11040 ^@ http://purl.uniprot.org/uniprot/E8R3P9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0161 family.|||Cell inner membrane|||Could be involved in insertion of integral membrane proteins into the membrane. http://togogenome.org/gene/575540:ISOP_RS12235 ^@ http://purl.uniprot.org/uniprot/E8R5U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0382 family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS14665 ^@ http://purl.uniprot.org/uniprot/E8R0I3 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/575540:ISOP_RS06490 ^@ http://purl.uniprot.org/uniprot/E8R6A6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferrochelatase family.|||Catalyzes the ferrous insertion into protoporphyrin IX.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS19205 ^@ http://purl.uniprot.org/uniprot/E8QYG4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS03120 ^@ http://purl.uniprot.org/uniprot/E8R059 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/575540:ISOP_RS09875 ^@ http://purl.uniprot.org/uniprot/E8R1Y6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS04855 ^@ http://purl.uniprot.org/uniprot/E8R300 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.|||Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS02245 ^@ http://purl.uniprot.org/uniprot/E8QYP2 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/575540:ISOP_RS08445 ^@ http://purl.uniprot.org/uniprot/E8QZN2 ^@ Similarity ^@ Belongs to the acetyl-CoA hydrolase/transferase family. http://togogenome.org/gene/575540:ISOP_RS18250 ^@ http://purl.uniprot.org/uniprot/E8R6S3 ^@ Similarity ^@ Belongs to the low molecular weight phosphotyrosine protein phosphatase family. http://togogenome.org/gene/575540:ISOP_RS19725 ^@ http://purl.uniprot.org/uniprot/E8QZA8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IspF family.|||Binds 1 divalent metal cation per subunit.|||Homotrimer.|||Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS09405 ^@ http://purl.uniprot.org/uniprot/E8R0Y7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MlaE permease family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/575540:ISOP_RS09660 ^@ http://purl.uniprot.org/uniprot/E8R1F8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS04560 ^@ http://purl.uniprot.org/uniprot/E8R2G4 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS13260 ^@ http://purl.uniprot.org/uniprot/E8QXJ9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.|||An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.|||Belongs to the DTD family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/575540:ISOP_RS11390 ^@ http://purl.uniprot.org/uniprot/E8R497 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS11975 ^@ http://purl.uniprot.org/uniprot/E8R547 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS07980 ^@ http://purl.uniprot.org/uniprot/E8QYU4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/575540:ISOP_RS06380 ^@ http://purl.uniprot.org/uniprot/E8R5N5 ^@ Similarity ^@ Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. http://togogenome.org/gene/575540:ISOP_RS19515 ^@ http://purl.uniprot.org/uniprot/E8QZ73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 1 family.|||Cell inner membrane|||Cell membrane|||Membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. http://togogenome.org/gene/575540:ISOP_RS04200 ^@ http://purl.uniprot.org/uniprot/E8R1W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS05675 ^@ http://purl.uniprot.org/uniprot/E8R470 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 87 family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS06855 ^@ http://purl.uniprot.org/uniprot/E8QWI2 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/575540:ISOP_RS03510 ^@ http://purl.uniprot.org/uniprot/E8R0R8 ^@ Similarity ^@ Belongs to the creatininase superfamily. http://togogenome.org/gene/575540:ISOP_RS09855 ^@ http://purl.uniprot.org/uniprot/E8R1Y2 ^@ Similarity ^@ In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.|||In the central section; belongs to the CRISPR-associated helicase Cas3 family. http://togogenome.org/gene/575540:ISOP_RS08010 ^@ http://purl.uniprot.org/uniprot/E8QYV0 ^@ Function|||Subunit ^@ Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.|||The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP). http://togogenome.org/gene/575540:ISOP_RS18155 ^@ http://purl.uniprot.org/uniprot/E8R6Q8 ^@ Similarity ^@ Belongs to the KHG/KDPG aldolase family. http://togogenome.org/gene/575540:ISOP_RS00060 ^@ http://purl.uniprot.org/uniprot/E8R4L7 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/575540:ISOP_RS15610 ^@ http://purl.uniprot.org/uniprot/E8R258 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the selenophosphate synthase 1 family. Class I subfamily.|||Binds 1 Mg(2+) ion per monomer.|||Homodimer.|||Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/575540:ISOP_RS14225 ^@ http://purl.uniprot.org/uniprot/E8QZU1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspG family.|||Binds 1 [4Fe-4S] cluster.|||Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. http://togogenome.org/gene/575540:ISOP_RS11665 ^@ http://purl.uniprot.org/uniprot/E8R4Z0 ^@ Function|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.|||This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/575540:ISOP_RS19505 ^@ http://purl.uniprot.org/uniprot/E8QZ71 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 6 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/575540:ISOP_RS14600 ^@ http://purl.uniprot.org/uniprot/E8R0H2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS09270 ^@ http://purl.uniprot.org/uniprot/E8R0W2 ^@ Function|||Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/575540:ISOP_RS17090 ^@ http://purl.uniprot.org/uniprot/E8R4H7 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Non-allosteric. http://togogenome.org/gene/575540:ISOP_RS08175 ^@ http://purl.uniprot.org/uniprot/E8QYY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS08295 ^@ http://purl.uniprot.org/uniprot/E8QZK4 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS06590 ^@ http://purl.uniprot.org/uniprot/E8R6C4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS08885 ^@ http://purl.uniprot.org/uniprot/E8R0B4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).|||Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1. http://togogenome.org/gene/575540:ISOP_RS14025 ^@ http://purl.uniprot.org/uniprot/E8QZ51 ^@ Similarity ^@ Belongs to the peptidase S41A family. http://togogenome.org/gene/575540:ISOP_RS16515 ^@ http://purl.uniprot.org/uniprot/E8R3E7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS00780 ^@ http://purl.uniprot.org/uniprot/E8R641 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS07965 ^@ http://purl.uniprot.org/uniprot/E8QYU1 ^@ Similarity ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. http://togogenome.org/gene/575540:ISOP_RS02045 ^@ http://purl.uniprot.org/uniprot/E8QY01 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS12255 ^@ http://purl.uniprot.org/uniprot/E8R5U9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/575540:ISOP_RS01650 ^@ http://purl.uniprot.org/uniprot/E8QX69 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/575540:ISOP_RS16800 ^@ http://purl.uniprot.org/uniprot/E8R3Y6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.|||Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.|||Monomer. http://togogenome.org/gene/575540:ISOP_RS07855 ^@ http://purl.uniprot.org/uniprot/E8QY67 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS03090 ^@ http://purl.uniprot.org/uniprot/E8R053 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/575540:ISOP_RS05280 ^@ http://purl.uniprot.org/uniprot/E8R3L8 ^@ Similarity ^@ Belongs to the asparagine synthetase family. http://togogenome.org/gene/575540:ISOP_RS02860 ^@ http://purl.uniprot.org/uniprot/E8QZJ9 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/575540:ISOP_RS15450 ^@ http://purl.uniprot.org/uniprot/E8R1P0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/575540:ISOP_RS12265 ^@ http://purl.uniprot.org/uniprot/E8R5V1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS19275 ^@ http://purl.uniprot.org/uniprot/E8QYH5 ^@ Similarity ^@ Belongs to the threonine aldolase family. http://togogenome.org/gene/575540:ISOP_RS02750 ^@ http://purl.uniprot.org/uniprot/E8QZH9 ^@ Similarity ^@ Belongs to the BlaI transcriptional regulatory family. http://togogenome.org/gene/575540:ISOP_RS18415 ^@ http://purl.uniprot.org/uniprot/E8QWW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/575540:ISOP_RS08030 ^@ http://purl.uniprot.org/uniprot/E8QYV4 ^@ Caution|||Function|||Similarity ^@ Belongs to the UbiX/PAD1 family.|||Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS01240 ^@ http://purl.uniprot.org/uniprot/E8QWD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DedA family.|||Cell membrane|||Membrane http://togogenome.org/gene/575540:ISOP_RS06300 ^@ http://purl.uniprot.org/uniprot/E8R5M3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/575540:ISOP_RS11265 ^@ http://purl.uniprot.org/uniprot/E8R3T9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/575540:ISOP_RS09595 ^@ http://purl.uniprot.org/uniprot/E8R1E9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS00605 ^@ http://purl.uniprot.org/uniprot/E8R5G9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/575540:ISOP_RS00310 ^@ http://purl.uniprot.org/uniprot/E8R5B6 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/575540:ISOP_RS14715 ^@ http://purl.uniprot.org/uniprot/E8R0J2 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily. http://togogenome.org/gene/575540:ISOP_RS17420 ^@ http://purl.uniprot.org/uniprot/E8R578 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS05035 ^@ http://purl.uniprot.org/uniprot/E8R3H0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methylthiotransferase family. RimO subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS06765 ^@ http://purl.uniprot.org/uniprot/E8R6F6 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family. http://togogenome.org/gene/575540:ISOP_RS07745 ^@ http://purl.uniprot.org/uniprot/E8QY45 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. http://togogenome.org/gene/575540:ISOP_RS14000 ^@ http://purl.uniprot.org/uniprot/E8QZ46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/575540:ISOP_RS20850 ^@ http://purl.uniprot.org/uniprot/E8R1D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS07710 ^@ http://purl.uniprot.org/uniprot/E8QY38 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.|||In the C-terminal section; belongs to the NAD synthetase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS06645 ^@ http://purl.uniprot.org/uniprot/E8R6D6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS01710 ^@ http://purl.uniprot.org/uniprot/E8QX79 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). http://togogenome.org/gene/575540:ISOP_RS02810 ^@ http://purl.uniprot.org/uniprot/E8QZI9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FTR family.|||Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT).|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/575540:ISOP_RS13275 ^@ http://purl.uniprot.org/uniprot/E8QXK1 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily. http://togogenome.org/gene/575540:ISOP_RS14740 ^@ http://purl.uniprot.org/uniprot/E8R0J7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS15855 ^@ http://purl.uniprot.org/uniprot/E8R2A8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/575540:ISOP_RS05185 ^@ http://purl.uniprot.org/uniprot/E8R3J8 ^@ Similarity ^@ Belongs to the peptidase M29 family. http://togogenome.org/gene/575540:ISOP_RS18565 ^@ http://purl.uniprot.org/uniprot/E8QWZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DedA family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS08370 ^@ http://purl.uniprot.org/uniprot/E8QZL6 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/575540:ISOP_RS02205 ^@ http://purl.uniprot.org/uniprot/E8QYN5 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/575540:ISOP_RS12495 ^@ http://purl.uniprot.org/uniprot/E8R6J3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS04080 ^@ http://purl.uniprot.org/uniprot/E8R1T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gas vesicle GvpF/GvpL family.|||Gas vesicle|||Vesicle http://togogenome.org/gene/575540:ISOP_RS06225 ^@ http://purl.uniprot.org/uniprot/E8R5K9 ^@ Similarity|||Subunit ^@ Belongs to the transketolase family.|||Homodimer. http://togogenome.org/gene/575540:ISOP_RS11230 ^@ http://purl.uniprot.org/uniprot/E8R3T2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/575540:ISOP_RS06115 ^@ http://purl.uniprot.org/uniprot/E8R5I9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the zinc-containing alcohol dehydrogenase family.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/575540:ISOP_RS02140 ^@ http://purl.uniprot.org/uniprot/E8QYM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/575540:ISOP_RS13980 ^@ http://purl.uniprot.org/uniprot/E8QZ42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transaldolase family. Type 1 subfamily.|||Cytoplasm|||Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. http://togogenome.org/gene/575540:ISOP_RS07525 ^@ http://purl.uniprot.org/uniprot/E8QXF7 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/575540:ISOP_RS16760 ^@ http://purl.uniprot.org/uniprot/E8R3X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/575540:ISOP_RS11100 ^@ http://purl.uniprot.org/uniprot/E8R3Q9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS16620 ^@ http://purl.uniprot.org/uniprot/E8R3V0 ^@ Function|||Similarity ^@ Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.|||Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). http://togogenome.org/gene/575540:ISOP_RS11020 ^@ http://purl.uniprot.org/uniprot/E8R3P5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. TreS subfamily. http://togogenome.org/gene/575540:ISOP_RS00580 ^@ http://purl.uniprot.org/uniprot/E8R5G5 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/575540:ISOP_RS10055 ^@ http://purl.uniprot.org/uniprot/E8R219 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS20415 ^@ http://purl.uniprot.org/uniprot/E8R0R3 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/575540:ISOP_RS05040 ^@ http://purl.uniprot.org/uniprot/E8R3H1 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/575540:ISOP_RS14930 ^@ http://purl.uniprot.org/uniprot/E8R111 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/575540:ISOP_RS02820 ^@ http://purl.uniprot.org/uniprot/E8QZJ1 ^@ Domain|||Similarity ^@ Belongs to the PurH family.|||The IMP cyclohydrolase activity resides in the N-terminal region. http://togogenome.org/gene/575540:ISOP_RS01805 ^@ http://purl.uniprot.org/uniprot/E8QXV3 ^@ Caution|||Function|||Similarity ^@ Belongs to the GART family.|||Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS17735 ^@ http://purl.uniprot.org/uniprot/E8R5Y4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueA family.|||Cytoplasm|||Monomer.|||Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). http://togogenome.org/gene/575540:ISOP_RS11835 ^@ http://purl.uniprot.org/uniprot/E8R522 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CpxP/Spy family.|||Periplasm http://togogenome.org/gene/575540:ISOP_RS10735 ^@ http://purl.uniprot.org/uniprot/E8R358 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/575540:ISOP_RS02980 ^@ http://purl.uniprot.org/uniprot/E8R032 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase A chain family.|||Cell inner membrane|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.|||Membrane http://togogenome.org/gene/575540:ISOP_RS02735 ^@ http://purl.uniprot.org/uniprot/E8QZH7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/575540:ISOP_RS09035 ^@ http://purl.uniprot.org/uniprot/E8R0E0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/575540:ISOP_RS14590 ^@ http://purl.uniprot.org/uniprot/E8R0H0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 1 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/575540:ISOP_RS15615 ^@ http://purl.uniprot.org/uniprot/E8R259 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/575540:ISOP_RS07450 ^@ http://purl.uniprot.org/uniprot/E8QXE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/575540:ISOP_RS15970 ^@ http://purl.uniprot.org/uniprot/E8R2R3 ^@ Similarity ^@ Belongs to the sigma-54 factor family. http://togogenome.org/gene/575540:ISOP_RS03555 ^@ http://purl.uniprot.org/uniprot/E8R155 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/575540:ISOP_RS16615 ^@ http://purl.uniprot.org/uniprot/E8R3U9 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily. http://togogenome.org/gene/575540:ISOP_RS15055 ^@ http://purl.uniprot.org/uniprot/E8R134 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/575540:ISOP_RS14350 ^@ http://purl.uniprot.org/uniprot/E8QZW5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. N-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/575540:ISOP_RS00915 ^@ http://purl.uniprot.org/uniprot/E8R666 ^@ Similarity ^@ Belongs to the peptidase T1B family. HslV subfamily. http://togogenome.org/gene/575540:ISOP_RS08665 ^@ http://purl.uniprot.org/uniprot/E8QZR8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS08810 ^@ http://purl.uniprot.org/uniprot/E8R0A2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS20120 ^@ http://purl.uniprot.org/uniprot/E8R6W5 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/575540:ISOP_RS11090 ^@ http://purl.uniprot.org/uniprot/E8R3Q7 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS09390 ^@ http://purl.uniprot.org/uniprot/E8R0Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS08325 ^@ http://purl.uniprot.org/uniprot/E8QZK7 ^@ Function|||Similarity ^@ Belongs to the MoeA family.|||Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. http://togogenome.org/gene/575540:ISOP_RS15050 ^@ http://purl.uniprot.org/uniprot/E8R133 ^@ Similarity ^@ Belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/575540:ISOP_RS20720 ^@ http://purl.uniprot.org/uniprot/E8QYV2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS15190 ^@ http://purl.uniprot.org/uniprot/E8R1J2 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/575540:ISOP_RS19425 ^@ http://purl.uniprot.org/uniprot/E8QYK2 ^@ Similarity ^@ Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/575540:ISOP_RS07430 ^@ http://purl.uniprot.org/uniprot/E8QXE0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS14375 ^@ http://purl.uniprot.org/uniprot/E8QZW9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/575540:ISOP_RS11070 ^@ http://purl.uniprot.org/uniprot/E8R3Q4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/575540:ISOP_RS15040 ^@ http://purl.uniprot.org/uniprot/E8R131 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.|||Cell inner membrane|||Mediates magnesium influx to the cytosol.|||Membrane http://togogenome.org/gene/575540:ISOP_RS05560 ^@ http://purl.uniprot.org/uniprot/E8R449 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/575540:ISOP_RS18995 ^@ http://purl.uniprot.org/uniprot/E8QXS4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase S24 family.|||Homodimer.|||Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. http://togogenome.org/gene/575540:ISOP_RS08275 ^@ http://purl.uniprot.org/uniprot/E8QYZ9 ^@ Cofactor|||Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/575540:ISOP_RS16670 ^@ http://purl.uniprot.org/uniprot/E8R3V9 ^@ Similarity ^@ Belongs to the UDP-N-acetylglucosamine 2-epimerase family. http://togogenome.org/gene/575540:ISOP_RS18720 ^@ http://purl.uniprot.org/uniprot/E8QX22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Brp/Blh beta-carotene diooxygenase family.|||Catalyzes the cleavage of beta-carotene at its central double bond (15,15') to yield two molecules of all-trans-retinal.|||Cell membrane http://togogenome.org/gene/575540:ISOP_RS00970 ^@ http://purl.uniprot.org/uniprot/E8R677 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS05630 ^@ http://purl.uniprot.org/uniprot/E8R462 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/575540:ISOP_RS14580 ^@ http://purl.uniprot.org/uniprot/E8R0G8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS15125 ^@ http://purl.uniprot.org/uniprot/E8R147 ^@ Caution|||Similarity ^@ Belongs to the peptidase S8 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS20240 ^@ http://purl.uniprot.org/uniprot/E8R5H6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS15730 ^@ http://purl.uniprot.org/uniprot/E8R283 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/575540:ISOP_RS03095 ^@ http://purl.uniprot.org/uniprot/E8R054 ^@ Caution|||Function|||Similarity ^@ Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. http://togogenome.org/gene/575540:ISOP_RS06535 ^@ http://purl.uniprot.org/uniprot/E8R6B5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/575540:ISOP_RS17570 ^@ http://purl.uniprot.org/uniprot/E8R5A3 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/575540:ISOP_RS07215 ^@ http://purl.uniprot.org/uniprot/E8QX99 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS02910 ^@ http://purl.uniprot.org/uniprot/E8R018 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/575540:ISOP_RS01740 ^@ http://purl.uniprot.org/uniprot/E8QX85 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/575540:ISOP_RS00185 ^@ http://purl.uniprot.org/uniprot/E8R4P3 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.|||Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/575540:ISOP_RS08005 ^@ http://purl.uniprot.org/uniprot/E8QYU9 ^@ Function|||Subunit ^@ Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.|||The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP). http://togogenome.org/gene/575540:ISOP_RS08485 ^@ http://purl.uniprot.org/uniprot/E8QZP0 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase class-2 family.|||Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. http://togogenome.org/gene/575540:ISOP_RS17150 ^@ http://purl.uniprot.org/uniprot/E8R4I6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.|||Cell inner membrane|||Membrane|||Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. http://togogenome.org/gene/575540:ISOP_RS12045 ^@ http://purl.uniprot.org/uniprot/E8R5R0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/575540:ISOP_RS07315 ^@ http://purl.uniprot.org/uniprot/E8QXB8 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/575540:ISOP_RS11295 ^@ http://purl.uniprot.org/uniprot/E8R479 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/575540:ISOP_RS14255 ^@ http://purl.uniprot.org/uniprot/E8QZU8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.|||Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).|||Homodimer. http://togogenome.org/gene/575540:ISOP_RS11255 ^@ http://purl.uniprot.org/uniprot/E8R3T7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/575540:ISOP_RS20035 ^@ http://purl.uniprot.org/uniprot/E8R6U8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.|||Binds 1 Mn(2+) ion per subunit.|||Cytoplasm|||Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS11790 ^@ http://purl.uniprot.org/uniprot/E8R513 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/575540:ISOP_RS10105 ^@ http://purl.uniprot.org/uniprot/E8R230 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/575540:ISOP_RS15065 ^@ http://purl.uniprot.org/uniprot/E8R135 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/575540:ISOP_RS00735 ^@ http://purl.uniprot.org/uniprot/E8R634 ^@ Similarity|||Subunit ^@ Belongs to the KdsC family.|||Homotetramer. http://togogenome.org/gene/575540:ISOP_RS05410 ^@ http://purl.uniprot.org/uniprot/E8R422 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/575540:ISOP_RS01235 ^@ http://purl.uniprot.org/uniprot/E8QWD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/575540:ISOP_RS16520 ^@ http://purl.uniprot.org/uniprot/E8R3E8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS05525 ^@ http://purl.uniprot.org/uniprot/E8R443 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/575540:ISOP_RS08705 ^@ http://purl.uniprot.org/uniprot/E8R085 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/575540:ISOP_RS15370 ^@ http://purl.uniprot.org/uniprot/E8R1M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.|||Cell membrane|||Membrane http://togogenome.org/gene/575540:ISOP_RS08695 ^@ http://purl.uniprot.org/uniprot/E8R083 ^@ Similarity ^@ Belongs to the bacterial microcompartments protein family. http://togogenome.org/gene/575540:ISOP_RS18055 ^@ http://purl.uniprot.org/uniprot/E8R6N9 ^@ Similarity ^@ Belongs to the peptidase C56 family. http://togogenome.org/gene/575540:ISOP_RS00075 ^@ http://purl.uniprot.org/uniprot/E8R4L9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/575540:ISOP_RS11210 ^@ http://purl.uniprot.org/uniprot/E8R3S8 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/575540:ISOP_RS07210 ^@ http://purl.uniprot.org/uniprot/E8QX98 ^@ Function ^@ Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. http://togogenome.org/gene/575540:ISOP_RS04115 ^@ http://purl.uniprot.org/uniprot/E8R1U1 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/575540:ISOP_RS02445 ^@ http://purl.uniprot.org/uniprot/E8QYS9 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/575540:ISOP_RS13985 ^@ http://purl.uniprot.org/uniprot/E8QZ43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI family.|||Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS10070 ^@ http://purl.uniprot.org/uniprot/E8R222 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/575540:ISOP_RS13970 ^@ http://purl.uniprot.org/uniprot/E8QZ40 ^@ Similarity ^@ Belongs to the peptidase C56 family. http://togogenome.org/gene/575540:ISOP_RS11130 ^@ http://purl.uniprot.org/uniprot/E8R3R3 ^@ Function|||Similarity ^@ Belongs to the class-I DAHP synthase family.|||Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). http://togogenome.org/gene/575540:ISOP_RS14410 ^@ http://purl.uniprot.org/uniprot/E8QZX6 ^@ Similarity ^@ Belongs to the iron-sulfur dependent L-serine dehydratase family. http://togogenome.org/gene/575540:ISOP_RS14270 ^@ http://purl.uniprot.org/uniprot/E8QZV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal stress protein A family.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS05025 ^@ http://purl.uniprot.org/uniprot/E8R3G9 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/575540:ISOP_RS04505 ^@ http://purl.uniprot.org/uniprot/E8R2F3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS08340 ^@ http://purl.uniprot.org/uniprot/E8QZL0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS17415 ^@ http://purl.uniprot.org/uniprot/E8R577 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Maf family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. http://togogenome.org/gene/575540:ISOP_RS18530 ^@ http://purl.uniprot.org/uniprot/E8QWY6 ^@ Caution|||Function|||Similarity ^@ Belongs to the ATP:guanido phosphotransferase family.|||Catalyzes the specific phosphorylation of arginine residues in proteins.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS11535 ^@ http://purl.uniprot.org/uniprot/E8R4C3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA. http://togogenome.org/gene/575540:ISOP_RS03225 ^@ http://purl.uniprot.org/uniprot/E8R0L1 ^@ Similarity ^@ Belongs to the prokaryotic/mitochondrial release factor family. http://togogenome.org/gene/575540:ISOP_RS21400 ^@ http://purl.uniprot.org/uniprot/E8R5Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/575540:ISOP_RS11600 ^@ http://purl.uniprot.org/uniprot/E8R4D3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS17770 ^@ http://purl.uniprot.org/uniprot/E8R5Z1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS04415 ^@ http://purl.uniprot.org/uniprot/E8R2D7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS02925 ^@ http://purl.uniprot.org/uniprot/E8R021 ^@ Similarity ^@ Belongs to the LOG family. http://togogenome.org/gene/575540:ISOP_RS12415 ^@ http://purl.uniprot.org/uniprot/E8R6H7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.|||Belongs to the RNR ribonuclease family. RNase R subfamily.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS06065 ^@ http://purl.uniprot.org/uniprot/E8R4Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS20580 ^@ http://purl.uniprot.org/uniprot/E8R461 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/575540:ISOP_RS06630 ^@ http://purl.uniprot.org/uniprot/E8R6D3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/575540:ISOP_RS08350 ^@ http://purl.uniprot.org/uniprot/E8QZL2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.|||Belongs to the CsrA/RsmA family.|||Cytoplasm|||Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core. http://togogenome.org/gene/575540:ISOP_RS15620 ^@ http://purl.uniprot.org/uniprot/E8R260 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/575540:ISOP_RS00235 ^@ http://purl.uniprot.org/uniprot/E8R4Q2 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/575540:ISOP_RS06580 ^@ http://purl.uniprot.org/uniprot/E8R6C2 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/575540:ISOP_RS17730 ^@ http://purl.uniprot.org/uniprot/E8R5Y3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS14210 ^@ http://purl.uniprot.org/uniprot/E8QZT8 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/575540:ISOP_RS18025 ^@ http://purl.uniprot.org/uniprot/E8R6N5 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/575540:ISOP_RS16290 ^@ http://purl.uniprot.org/uniprot/E8R3A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS11200 ^@ http://purl.uniprot.org/uniprot/E8R3S6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/575540:ISOP_RS22625 ^@ http://purl.uniprot.org/uniprot/E8QZR7 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/575540:ISOP_RS04470 ^@ http://purl.uniprot.org/uniprot/E8R2E7 ^@ Function|||Subunit ^@ Heterodimer of an alpha and a beta chain.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. http://togogenome.org/gene/575540:ISOP_RS13425 ^@ http://purl.uniprot.org/uniprot/E8QY82 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/575540:ISOP_RS05870 ^@ http://purl.uniprot.org/uniprot/E8R4U5 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.|||Cell inner membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Requires K(+) for maximal activity.|||Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane. http://togogenome.org/gene/575540:ISOP_RS03580 ^@ http://purl.uniprot.org/uniprot/E8R160 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/575540:ISOP_RS11220 ^@ http://purl.uniprot.org/uniprot/E8R3T0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/575540:ISOP_RS15355 ^@ http://purl.uniprot.org/uniprot/E8R1M4 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. http://togogenome.org/gene/575540:ISOP_RS17855 ^@ http://purl.uniprot.org/uniprot/E8R607 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/575540:ISOP_RS00255 ^@ http://purl.uniprot.org/uniprot/E8R4Q6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS07435 ^@ http://purl.uniprot.org/uniprot/E8QXE1 ^@ Similarity ^@ Belongs to the UxaA family. http://togogenome.org/gene/575540:ISOP_RS04985 ^@ http://purl.uniprot.org/uniprot/E8R3G2 ^@ Similarity ^@ Belongs to the HY2 family. http://togogenome.org/gene/575540:ISOP_RS00560 ^@ http://purl.uniprot.org/uniprot/E8R5G2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/575540:ISOP_RS19895 ^@ http://purl.uniprot.org/uniprot/E8QZZ2 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/575540:ISOP_RS20610 ^@ http://purl.uniprot.org/uniprot/E8R5J2 ^@ Function|||Similarity ^@ In the N-terminal section; belongs to the phytochrome family.|||Regulatory photoreceptor which exists in two forms that are reversibly interconvertible by light: the Pr form that absorbs maximally in the red region of the spectrum and the Pfr form that absorbs maximally in the far-red region. Photoconversion of Pr to Pfr induces an array of morphogenic responses, whereas reconversion of Pfr to Pr cancels the induction of those responses. Pfr controls the expression of a number of nuclear genes including those encoding the small subunit of ribulose-bisphosphate carboxylase, chlorophyll A/B binding protein, protochlorophyllide reductase, rRNA, etc. It also controls the expression of its own gene(s) in a negative feedback fashion. http://togogenome.org/gene/575540:ISOP_RS01080 ^@ http://purl.uniprot.org/uniprot/E8QWA5 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/575540:ISOP_RS08050 ^@ http://purl.uniprot.org/uniprot/E8QYV8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xylose isomerase family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/575540:ISOP_RS05680 ^@ http://purl.uniprot.org/uniprot/E8R471 ^@ Similarity ^@ Belongs to the RibF family. http://togogenome.org/gene/575540:ISOP_RS05445 ^@ http://purl.uniprot.org/uniprot/E8R430 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 13 family.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS10090 ^@ http://purl.uniprot.org/uniprot/E8R226 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylate kinase family.|||Cytoplasm|||Essential for recycling GMP and indirectly, cGMP. http://togogenome.org/gene/575540:ISOP_RS15300 ^@ http://purl.uniprot.org/uniprot/E8R1L4 ^@ Similarity ^@ Belongs to the DSD1 family. http://togogenome.org/gene/575540:ISOP_RS01940 ^@ http://purl.uniprot.org/uniprot/E8QXY0 ^@ Similarity ^@ Belongs to the FrhG family. http://togogenome.org/gene/575540:ISOP_RS04090 ^@ http://purl.uniprot.org/uniprot/E8R1T7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CbbQ/NirQ/NorQ/GpvN family.|||Cytoplasm|||Gas vesicle|||Vesicle http://togogenome.org/gene/575540:ISOP_RS09285 ^@ http://purl.uniprot.org/uniprot/E8R0W6 ^@ Similarity ^@ Belongs to the UPF0145 family. http://togogenome.org/gene/575540:ISOP_RS17180 ^@ http://purl.uniprot.org/uniprot/E8R4J3 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. Ycf16 family. http://togogenome.org/gene/575540:ISOP_RS12900 ^@ http://purl.uniprot.org/uniprot/E8QWS9 ^@ Similarity ^@ Belongs to the CobT family. http://togogenome.org/gene/575540:ISOP_RS01480 ^@ http://purl.uniprot.org/uniprot/E8QX39 ^@ Function|||Similarity ^@ Belongs to the PNP/MTAP phosphorylase family.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/575540:ISOP_RS12645 ^@ http://purl.uniprot.org/uniprot/E8R6L9 ^@ Similarity ^@ Belongs to the RecJ family. http://togogenome.org/gene/575540:ISOP_RS17785 ^@ http://purl.uniprot.org/uniprot/E8R5Z4 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/575540:ISOP_RS11235 ^@ http://purl.uniprot.org/uniprot/E8R3T3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/575540:ISOP_RS20520 ^@ http://purl.uniprot.org/uniprot/E8R3H5 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/575540:ISOP_RS19500 ^@ http://purl.uniprot.org/uniprot/E8QZ70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4L family.|||Cell inner membrane|||Membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/575540:ISOP_RS18960 ^@ http://purl.uniprot.org/uniprot/E8QXR7 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/575540:ISOP_RS15490 ^@ http://purl.uniprot.org/uniprot/E8R1P8 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the thiamine-phosphate synthase family.|||Binds 1 Mg(2+) ion per subunit.|||Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS11915 ^@ http://purl.uniprot.org/uniprot/E8R535 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/575540:ISOP_RS03470 ^@ http://purl.uniprot.org/uniprot/E8R0R1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. ArgB subfamily.|||Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS00820 ^@ http://purl.uniprot.org/uniprot/E8R648 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/575540:ISOP_RS04230 ^@ http://purl.uniprot.org/uniprot/E8R1W6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.|||Cell inner membrane|||Forms a complex with DabB.|||Part of an energy-coupled inorganic carbon pump. http://togogenome.org/gene/575540:ISOP_RS06750 ^@ http://purl.uniprot.org/uniprot/E8R6F4 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/575540:ISOP_RS15675 ^@ http://purl.uniprot.org/uniprot/E8R272 ^@ Similarity ^@ In the N-terminal section; belongs to the phytochrome family. http://togogenome.org/gene/575540:ISOP_RS04160 ^@ http://purl.uniprot.org/uniprot/E8R1V1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NrfD family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS17045 ^@ http://purl.uniprot.org/uniprot/E8R4G8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS11195 ^@ http://purl.uniprot.org/uniprot/E8R3S5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/575540:ISOP_RS08700 ^@ http://purl.uniprot.org/uniprot/E8R084 ^@ Similarity ^@ Belongs to the bacterial microcompartments protein family. http://togogenome.org/gene/575540:ISOP_RS20680 ^@ http://purl.uniprot.org/uniprot/E8QWN7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS02775 ^@ http://purl.uniprot.org/uniprot/E8QZI3 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/575540:ISOP_RS18240 ^@ http://purl.uniprot.org/uniprot/E8R6S1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.|||Belongs to the CsrA/RsmA family.|||Cytoplasm|||Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core. http://togogenome.org/gene/575540:ISOP_RS15185 ^@ http://purl.uniprot.org/uniprot/E8R1J1 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/575540:ISOP_RS19485 ^@ http://purl.uniprot.org/uniprot/E8QYL3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 2 family.|||Cell inner membrane|||Membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/575540:ISOP_RS16550 ^@ http://purl.uniprot.org/uniprot/E8R3F4 ^@ Similarity ^@ Belongs to the shaker potassium channel beta subunit family. http://togogenome.org/gene/575540:ISOP_RS09605 ^@ http://purl.uniprot.org/uniprot/E8R1F1 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/575540:ISOP_RS09260 ^@ http://purl.uniprot.org/uniprot/E8R0W0 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/575540:ISOP_RS14215 ^@ http://purl.uniprot.org/uniprot/E8QZT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.|||Cell inner membrane|||Membrane|||Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. http://togogenome.org/gene/575540:ISOP_RS09375 ^@ http://purl.uniprot.org/uniprot/E8R0Y2 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.|||Belongs to the peptidase S16 family.|||By heat shock.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity. http://togogenome.org/gene/575540:ISOP_RS19290 ^@ http://purl.uniprot.org/uniprot/E8QYH8 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/575540:ISOP_RS04105 ^@ http://purl.uniprot.org/uniprot/E8R1T9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gas vesicle GvpA family.|||Gas vesicle shell|||Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. During planktonic growth they allow positioning of the organism at a favorable depth for light or nutrient acquisition. GvpA forms the protein shell.|||The gas vesicle shell is 2 nm thick and consists of a single layer of this protein. It forms helical ribs nearly perpendicular to the long axis of the vesicle. http://togogenome.org/gene/575540:ISOP_RS11520 ^@ http://purl.uniprot.org/uniprot/E8R4C0 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.|||Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).|||The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.|||The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1. http://togogenome.org/gene/575540:ISOP_RS15670 ^@ http://purl.uniprot.org/uniprot/E8R270 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/575540:ISOP_RS02545 ^@ http://purl.uniprot.org/uniprot/E8QZE6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/575540:ISOP_RS11335 ^@ http://purl.uniprot.org/uniprot/E8R486 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS18220 ^@ http://purl.uniprot.org/uniprot/E8R6R9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS02355 ^@ http://purl.uniprot.org/uniprot/E8QYR2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.|||Belongs to the FliW family.|||Cytoplasm|||Interacts with translational regulator CsrA and flagellin(s). http://togogenome.org/gene/575540:ISOP_RS08365 ^@ http://purl.uniprot.org/uniprot/E8QZL5 ^@ Similarity ^@ Belongs to the carotenoid/retinoid oxidoreductase family. http://togogenome.org/gene/575540:ISOP_RS08240 ^@ http://purl.uniprot.org/uniprot/E8QYZ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS00550 ^@ http://purl.uniprot.org/uniprot/E8R5G1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/575540:ISOP_RS16525 ^@ http://purl.uniprot.org/uniprot/E8R3E9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.|||Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/575540:ISOP_RS10485 ^@ http://purl.uniprot.org/uniprot/E8R2N0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS06295 ^@ http://purl.uniprot.org/uniprot/E8R5M2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/575540:ISOP_RS13315 ^@ http://purl.uniprot.org/uniprot/E8QXL0 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/575540:ISOP_RS11240 ^@ http://purl.uniprot.org/uniprot/E8R3T4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/575540:ISOP_RS15995 ^@ http://purl.uniprot.org/uniprot/E8R2R7 ^@ Similarity|||Subunit ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.|||Homodimer. http://togogenome.org/gene/575540:ISOP_RS01960 ^@ http://purl.uniprot.org/uniprot/E8QXY4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS21240 ^@ http://purl.uniprot.org/uniprot/E8R1J5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS00155 ^@ http://purl.uniprot.org/uniprot/E8R4N6 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/575540:ISOP_RS11320 ^@ http://purl.uniprot.org/uniprot/E8R483 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/575540:ISOP_RS04455 ^@ http://purl.uniprot.org/uniprot/E8R2E5 ^@ Function|||Similarity ^@ Belongs to the aconitase/IPM isomerase family.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. http://togogenome.org/gene/575540:ISOP_RS17185 ^@ http://purl.uniprot.org/uniprot/E8R4J4 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/575540:ISOP_RS20005 ^@ http://purl.uniprot.org/uniprot/E8R011 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/575540:ISOP_RS03350 ^@ http://purl.uniprot.org/uniprot/E8R0N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS17290 ^@ http://purl.uniprot.org/uniprot/E8R554 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS00460 ^@ http://purl.uniprot.org/uniprot/E8R5E2 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/575540:ISOP_RS18725 ^@ http://purl.uniprot.org/uniprot/E8QX23 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal/bacterial/fungal opsin family.|||Contains one covalently linked retinal chromophore.|||Membrane http://togogenome.org/gene/575540:ISOP_RS08015 ^@ http://purl.uniprot.org/uniprot/E8QYV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic sulfate-binding protein family.|||Periplasm http://togogenome.org/gene/575540:ISOP_RS10595 ^@ http://purl.uniprot.org/uniprot/E8R332 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/575540:ISOP_RS18785 ^@ http://purl.uniprot.org/uniprot/E8QXN5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccD/PCCB family.|||Binds 1 zinc ion per subunit.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS03550 ^@ http://purl.uniprot.org/uniprot/E8R0S5 ^@ Domain|||Function|||Similarity ^@ Belongs to the vitamin-B12 dependent methionine synthase family.|||Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.|||Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin. http://togogenome.org/gene/575540:ISOP_RS06585 ^@ http://purl.uniprot.org/uniprot/E8R6C3 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/575540:ISOP_RS18205 ^@ http://purl.uniprot.org/uniprot/E8R6R6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/575540:ISOP_RS15220 ^@ http://purl.uniprot.org/uniprot/E8R1J8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribonuclease III family.|||Cytoplasm|||Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.|||Homodimer. http://togogenome.org/gene/575540:ISOP_RS00030 ^@ http://purl.uniprot.org/uniprot/E8R4L2 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS14510 ^@ http://purl.uniprot.org/uniprot/E8R0F5 ^@ Similarity ^@ Belongs to the ycf81 family. http://togogenome.org/gene/575540:ISOP_RS01545 ^@ http://purl.uniprot.org/uniprot/E8QX51 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family. http://togogenome.org/gene/575540:ISOP_RS15575 ^@ http://purl.uniprot.org/uniprot/E8R251 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/575540:ISOP_RS00675 ^@ http://purl.uniprot.org/uniprot/E8R5H7 ^@ Function|||Similarity ^@ ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.|||Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. http://togogenome.org/gene/575540:ISOP_RS18805 ^@ http://purl.uniprot.org/uniprot/E8QXN9 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/575540:ISOP_RS04690 ^@ http://purl.uniprot.org/uniprot/E8R2W9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Lgt family.|||Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.|||Cell inner membrane http://togogenome.org/gene/575540:ISOP_RS06810 ^@ http://purl.uniprot.org/uniprot/E8QWH4 ^@ Function|||Similarity ^@ Belongs to the LpxK family.|||Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). http://togogenome.org/gene/575540:ISOP_RS03380 ^@ http://purl.uniprot.org/uniprot/E8R0P4 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvA family.|||Cytoplasm|||Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.|||Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA. http://togogenome.org/gene/575540:ISOP_RS14760 ^@ http://purl.uniprot.org/uniprot/E8R0K1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP synthase family.|||Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.|||Cytoplasm|||Homooctamer; tetramer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS04625 ^@ http://purl.uniprot.org/uniprot/E8R2V7 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.|||Cell inner membrane|||Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.|||Membrane http://togogenome.org/gene/575540:ISOP_RS09830 ^@ http://purl.uniprot.org/uniprot/E8R1X7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/575540:ISOP_RS16530 ^@ http://purl.uniprot.org/uniprot/E8R3F0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Mg(2+) ion per subunit.|||Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.|||Cytoplasm|||Homotrimer.|||In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS14605 ^@ http://purl.uniprot.org/uniprot/E8R0H3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS06505 ^@ http://purl.uniprot.org/uniprot/E8R6A9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. TCR/Tet family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS00890 ^@ http://purl.uniprot.org/uniprot/E8R661 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/575540:ISOP_RS07740 ^@ http://purl.uniprot.org/uniprot/E8QY44 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/575540:ISOP_RS15155 ^@ http://purl.uniprot.org/uniprot/E8R153 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/575540:ISOP_RS00865 ^@ http://purl.uniprot.org/uniprot/E8R656 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/575540:ISOP_RS21195 ^@ http://purl.uniprot.org/uniprot/E8R0G2 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/575540:ISOP_RS02030 ^@ http://purl.uniprot.org/uniprot/E8QXZ8 ^@ Similarity ^@ Belongs to the UDPGP type 1 family. http://togogenome.org/gene/575540:ISOP_RS01670 ^@ http://purl.uniprot.org/uniprot/E8QX72 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/575540:ISOP_RS07695 ^@ http://purl.uniprot.org/uniprot/E8QY35 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the thiamine-monophosphate kinase family.|||Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. http://togogenome.org/gene/575540:ISOP_RS03900 ^@ http://purl.uniprot.org/uniprot/E8R1B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS20330 ^@ http://purl.uniprot.org/uniprot/E8QXW2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS05715 ^@ http://purl.uniprot.org/uniprot/E8R4R9 ^@ Function ^@ Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. http://togogenome.org/gene/575540:ISOP_RS15960 ^@ http://purl.uniprot.org/uniprot/E8R2R1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YbaB/EbfC family.|||Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.|||Homodimer.|||nucleoid http://togogenome.org/gene/575540:ISOP_RS09210 ^@ http://purl.uniprot.org/uniprot/E8R0V2 ^@ Similarity ^@ Belongs to the PstS family. http://togogenome.org/gene/575540:ISOP_RS07755 ^@ http://purl.uniprot.org/uniprot/E8QY47 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.|||Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.|||Homodimer. http://togogenome.org/gene/575540:ISOP_RS09960 ^@ http://purl.uniprot.org/uniprot/E8R202 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/575540:ISOP_RS01190 ^@ http://purl.uniprot.org/uniprot/E8QWC9 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/575540:ISOP_RS17065 ^@ http://purl.uniprot.org/uniprot/E8R4H2 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/575540:ISOP_RS17495 ^@ http://purl.uniprot.org/uniprot/E8R591 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S41B family.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS11190 ^@ http://purl.uniprot.org/uniprot/E8R3S4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/575540:ISOP_RS04615 ^@ http://purl.uniprot.org/uniprot/E8R2H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS16690 ^@ http://purl.uniprot.org/uniprot/E8R3W3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS15435 ^@ http://purl.uniprot.org/uniprot/E8R1N7 ^@ Caution|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS02715 ^@ http://purl.uniprot.org/uniprot/E8QZH4 ^@ Similarity ^@ Belongs to the asparagine synthetase family. http://togogenome.org/gene/575540:ISOP_RS16880 ^@ http://purl.uniprot.org/uniprot/E8R402 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/575540:ISOP_RS05305 ^@ http://purl.uniprot.org/uniprot/E8R3M3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/575540:ISOP_RS10130 ^@ http://purl.uniprot.org/uniprot/E8R233 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/575540:ISOP_RS15135 ^@ http://purl.uniprot.org/uniprot/E8R149 ^@ Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. http://togogenome.org/gene/575540:ISOP_RS07360 ^@ http://purl.uniprot.org/uniprot/E8QXC7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/575540:ISOP_RS01430 ^@ http://purl.uniprot.org/uniprot/E8QX30 ^@ Similarity ^@ Belongs to the Mg-chelatase subunits D/I family. ComM subfamily. http://togogenome.org/gene/575540:ISOP_RS10805 ^@ http://purl.uniprot.org/uniprot/E8R372 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/575540:ISOP_RS18870 ^@ http://purl.uniprot.org/uniprot/E8QXQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TsaE family.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS21555 ^@ http://purl.uniprot.org/uniprot/E8QZB6 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/575540:ISOP_RS05755 ^@ http://purl.uniprot.org/uniprot/E8R4S6 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/575540:ISOP_RS16870 ^@ http://purl.uniprot.org/uniprot/E8R3Z9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS08140 ^@ http://purl.uniprot.org/uniprot/E8QYX4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/575540:ISOP_RS15745 ^@ http://purl.uniprot.org/uniprot/E8R285 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/575540:ISOP_RS03575 ^@ http://purl.uniprot.org/uniprot/E8R159 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 49 kDa subunit family.|||Cell inner membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/575540:ISOP_RS09200 ^@ http://purl.uniprot.org/uniprot/E8R0V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/575540:ISOP_RS06665 ^@ http://purl.uniprot.org/uniprot/E8R6E0 ^@ Function|||Similarity ^@ Belongs to the MoeA family.|||Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. http://togogenome.org/gene/575540:ISOP_RS21300 ^@ http://purl.uniprot.org/uniprot/E8R397 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/575540:ISOP_RS02280 ^@ http://purl.uniprot.org/uniprot/E8QYP8 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/575540:ISOP_RS01030 ^@ http://purl.uniprot.org/uniprot/E8R688 ^@ Function|||Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate. http://togogenome.org/gene/575540:ISOP_RS03785 ^@ http://purl.uniprot.org/uniprot/E8R196 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/575540:ISOP_RS03190 ^@ http://purl.uniprot.org/uniprot/E8R071 ^@ Subcellular Location Annotation ^@ Periplasm http://togogenome.org/gene/575540:ISOP_RS02255 ^@ http://purl.uniprot.org/uniprot/E8QYP4 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/575540:ISOP_RS02780 ^@ http://purl.uniprot.org/uniprot/E8QZI4 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/575540:ISOP_RS05725 ^@ http://purl.uniprot.org/uniprot/E8R4S1 ^@ Similarity ^@ Belongs to the peptidase S41A family. http://togogenome.org/gene/575540:ISOP_RS10830 ^@ http://purl.uniprot.org/uniprot/E8R377 ^@ Function|||Similarity ^@ Belongs to the TenA family.|||Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. http://togogenome.org/gene/575540:ISOP_RS01180 ^@ http://purl.uniprot.org/uniprot/E8QWC7 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/575540:ISOP_RS06140 ^@ http://purl.uniprot.org/uniprot/E8R5J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/575540:ISOP_RS02955 ^@ http://purl.uniprot.org/uniprot/E8R027 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase gamma chain family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. http://togogenome.org/gene/575540:ISOP_RS09060 ^@ http://purl.uniprot.org/uniprot/E8R0S6 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/575540:ISOP_RS01425 ^@ http://purl.uniprot.org/uniprot/E8QX29 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/575540:ISOP_RS13890 ^@ http://purl.uniprot.org/uniprot/E8QZ24 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/575540:ISOP_RS14680 ^@ http://purl.uniprot.org/uniprot/E8R0I6 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.|||Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.|||Homodimer.|||Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. http://togogenome.org/gene/575540:ISOP_RS02120 ^@ http://purl.uniprot.org/uniprot/E8QYL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/575540:ISOP_RS19010 ^@ http://purl.uniprot.org/uniprot/E8QXS6 ^@ Similarity|||Subunit ^@ Belongs to the aldehyde dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/575540:ISOP_RS15690 ^@ http://purl.uniprot.org/uniprot/E8R277 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/575540:ISOP_RS02400 ^@ http://purl.uniprot.org/uniprot/E8QYS0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.|||Homotetramer. http://togogenome.org/gene/575540:ISOP_RS16770 ^@ http://purl.uniprot.org/uniprot/E8R3Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS02730 ^@ http://purl.uniprot.org/uniprot/E8QZH6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/575540:ISOP_RS02830 ^@ http://purl.uniprot.org/uniprot/E8QZJ3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/575540:ISOP_RS21050 ^@ http://purl.uniprot.org/uniprot/E8R6J8 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS09065 ^@ http://purl.uniprot.org/uniprot/E8R0S7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A monovalent cation. Ammonium or potassium.|||Belongs to the type III pantothenate kinase family.|||Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS15150 ^@ http://purl.uniprot.org/uniprot/E8R152 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/575540:ISOP_RS05775 ^@ http://purl.uniprot.org/uniprot/E8R4T0 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. http://togogenome.org/gene/575540:ISOP_RS20275 ^@ http://purl.uniprot.org/uniprot/E8R687 ^@ Similarity ^@ Belongs to the peptidase S11 family. http://togogenome.org/gene/575540:ISOP_RS14730 ^@ http://purl.uniprot.org/uniprot/E8R0J5 ^@ Similarity ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily. http://togogenome.org/gene/575540:ISOP_RS16255 ^@ http://purl.uniprot.org/uniprot/E8R399 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.|||Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS01965 ^@ http://purl.uniprot.org/uniprot/E8QXY5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS16510 ^@ http://purl.uniprot.org/uniprot/E8R3E6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the R-transferase family. Bpt subfamily.|||Cytoplasm|||Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate. http://togogenome.org/gene/575540:ISOP_RS01420 ^@ http://purl.uniprot.org/uniprot/E8QX28 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. http://togogenome.org/gene/575540:ISOP_RS04445 ^@ http://purl.uniprot.org/uniprot/E8R2E3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PAPS reductase family. CysH subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS09795 ^@ http://purl.uniprot.org/uniprot/E8R1I4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.|||Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).|||Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS07255 ^@ http://purl.uniprot.org/uniprot/E8QXA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS02510 ^@ http://purl.uniprot.org/uniprot/E8QZD9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/575540:ISOP_RS15625 ^@ http://purl.uniprot.org/uniprot/E8R261 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/575540:ISOP_RS03850 ^@ http://purl.uniprot.org/uniprot/E8R1A8 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/575540:ISOP_RS08505 ^@ http://purl.uniprot.org/uniprot/E8QZP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS01250 ^@ http://purl.uniprot.org/uniprot/E8QWE1 ^@ Similarity ^@ Belongs to the Cob(I)alamin adenosyltransferase family. http://togogenome.org/gene/575540:ISOP_RS01955 ^@ http://purl.uniprot.org/uniprot/E8QXY3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS19320 ^@ http://purl.uniprot.org/uniprot/E8QYI3 ^@ Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Homodimer. http://togogenome.org/gene/575540:ISOP_RS13560 ^@ http://purl.uniprot.org/uniprot/E8QYB0 ^@ Similarity ^@ Belongs to the intradiol ring-cleavage dioxygenase family. http://togogenome.org/gene/575540:ISOP_RS14475 ^@ http://purl.uniprot.org/uniprot/E8R0E7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.|||Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS02440 ^@ http://purl.uniprot.org/uniprot/E8QYS8 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/575540:ISOP_RS11630 ^@ http://purl.uniprot.org/uniprot/E8R4D9 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/575540:ISOP_RS11325 ^@ http://purl.uniprot.org/uniprot/E8R484 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/575540:ISOP_RS08390 ^@ http://purl.uniprot.org/uniprot/E8QZM0 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/575540:ISOP_RS03650 ^@ http://purl.uniprot.org/uniprot/E8R173 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatA/E family.|||Cell inner membrane|||Forms a complex with TatC.|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. http://togogenome.org/gene/575540:ISOP_RS04695 ^@ http://purl.uniprot.org/uniprot/E8R2X0 ^@ Caution|||Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanD family.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.|||Cytoplasm|||Heterooctamer of four alpha and four beta subunits.|||Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS16060 ^@ http://purl.uniprot.org/uniprot/E8R2S7 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/575540:ISOP_RS16435 ^@ http://purl.uniprot.org/uniprot/E8R3D3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/575540:ISOP_RS00685 ^@ http://purl.uniprot.org/uniprot/E8R5H9 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/575540:ISOP_RS05835 ^@ http://purl.uniprot.org/uniprot/E8R4T8 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/575540:ISOP_RS13270 ^@ http://purl.uniprot.org/uniprot/E8QXK0 ^@ Activity Regulation|||Caution|||Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Inhibited by fructose 1,6-bisphosphate (FBP).|||Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS12690 ^@ http://purl.uniprot.org/uniprot/E8R6M8 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/575540:ISOP_RS11035 ^@ http://purl.uniprot.org/uniprot/E8R3P8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RnpA family.|||Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.|||RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. http://togogenome.org/gene/575540:ISOP_RS01525 ^@ http://purl.uniprot.org/uniprot/E8QX47 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS16280 ^@ http://purl.uniprot.org/uniprot/E8R3A5 ^@ Caution|||Function|||Similarity ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family.|||Catalyzes the reversible oxidation of malate to oxaloacetate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS10865 ^@ http://purl.uniprot.org/uniprot/E8R384 ^@ Similarity ^@ Belongs to the ALAD family. http://togogenome.org/gene/575540:ISOP_RS05660 ^@ http://purl.uniprot.org/uniprot/E8R467 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.|||Cytoplasm|||In the C-terminal section; belongs to the helicase family. RecG subfamily.|||In the N-terminal section; belongs to the UvrB family. http://togogenome.org/gene/575540:ISOP_RS11940 ^@ http://purl.uniprot.org/uniprot/E8R540 ^@ Similarity ^@ Belongs to the phycobiliprotein family. http://togogenome.org/gene/575540:ISOP_RS12790 ^@ http://purl.uniprot.org/uniprot/E8QWR1 ^@ Caution|||Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS13790 ^@ http://purl.uniprot.org/uniprot/E8QZ09 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase S45 family.|||Binds 1 Ca(2+) ion per dimer. http://togogenome.org/gene/575540:ISOP_RS10630 ^@ http://purl.uniprot.org/uniprot/E8R337 ^@ Cofactor|||Similarity ^@ Belongs to the Fur family.|||Binds 1 Mn(2+) or Fe(2+) ion per subunit.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/575540:ISOP_RS13570 ^@ http://purl.uniprot.org/uniprot/E8QYB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS02965 ^@ http://purl.uniprot.org/uniprot/E8R029 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase delta chain family.|||Cell inner membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction. http://togogenome.org/gene/575540:ISOP_RS07370 ^@ http://purl.uniprot.org/uniprot/E8QXC9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.|||Belongs to the organic radical-activating enzymes family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS14030 ^@ http://purl.uniprot.org/uniprot/E8QZ52 ^@ Similarity ^@ Belongs to the peptidase S41A family. http://togogenome.org/gene/575540:ISOP_RS13195 ^@ http://purl.uniprot.org/uniprot/E8QXI6 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/575540:ISOP_RS18585 ^@ http://purl.uniprot.org/uniprot/E8QWZ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/575540:ISOP_RS00025 ^@ http://purl.uniprot.org/uniprot/E8R4L1 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/575540:ISOP_RS18800 ^@ http://purl.uniprot.org/uniprot/E8QXN8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/575540:ISOP_RS03455 ^@ http://purl.uniprot.org/uniprot/E8R0Q9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS05055 ^@ http://purl.uniprot.org/uniprot/E8R3H4 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/575540:ISOP_RS01770 ^@ http://purl.uniprot.org/uniprot/E8QXU5 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/575540:ISOP_RS15815 ^@ http://purl.uniprot.org/uniprot/E8R2A0 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/575540:ISOP_RS16275 ^@ http://purl.uniprot.org/uniprot/E8R3A4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS09280 ^@ http://purl.uniprot.org/uniprot/E8R0W5 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/575540:ISOP_RS09985 ^@ http://purl.uniprot.org/uniprot/E8R206 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/575540:ISOP_RS05620 ^@ http://purl.uniprot.org/uniprot/E8R460 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS17830 ^@ http://purl.uniprot.org/uniprot/E8R602 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS20400 ^@ http://purl.uniprot.org/uniprot/E8R0Q0 ^@ Similarity ^@ Belongs to the peptidase A24 family. http://togogenome.org/gene/575540:ISOP_RS04635 ^@ http://purl.uniprot.org/uniprot/E8R2V9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.|||Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS05850 ^@ http://purl.uniprot.org/uniprot/E8R4U1 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/575540:ISOP_RS09845 ^@ http://purl.uniprot.org/uniprot/E8R1Y0 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/575540:ISOP_RS07200 ^@ http://purl.uniprot.org/uniprot/E8QX96 ^@ Similarity|||Subunit ^@ Belongs to the FPG family.|||Monomer. http://togogenome.org/gene/575540:ISOP_RS00180 ^@ http://purl.uniprot.org/uniprot/E8R4P2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/575540:ISOP_RS10770 ^@ http://purl.uniprot.org/uniprot/E8R365 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/575540:ISOP_RS15045 ^@ http://purl.uniprot.org/uniprot/E8R132 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MgtC/SapB family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS06215 ^@ http://purl.uniprot.org/uniprot/E8R5K7 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/575540:ISOP_RS17435 ^@ http://purl.uniprot.org/uniprot/E8R581 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/575540:ISOP_RS18635 ^@ http://purl.uniprot.org/uniprot/E8QX07 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.|||Cytoplasm|||Heterotetramer of two alpha and two beta chains.|||Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway. http://togogenome.org/gene/575540:ISOP_RS00370 ^@ http://purl.uniprot.org/uniprot/E8R5C6 ^@ Similarity ^@ Belongs to the acyl coenzyme A hydrolase family. http://togogenome.org/gene/575540:ISOP_RS13775 ^@ http://purl.uniprot.org/uniprot/E8QZ06 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Arsenite methyltransferase family. http://togogenome.org/gene/575540:ISOP_RS03655 ^@ http://purl.uniprot.org/uniprot/E8R174 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS22755 ^@ http://purl.uniprot.org/uniprot/E8R583 ^@ Similarity ^@ Belongs to the type II topoisomerase GyrA/ParC subunit family. http://togogenome.org/gene/575540:ISOP_RS17000 ^@ http://purl.uniprot.org/uniprot/E8R4F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS17885 ^@ http://purl.uniprot.org/uniprot/E8R613 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/575540:ISOP_RS00730 ^@ http://purl.uniprot.org/uniprot/E8R633 ^@ Similarity ^@ Belongs to the SIS family. GutQ/KpsF subfamily. http://togogenome.org/gene/575540:ISOP_RS07075 ^@ http://purl.uniprot.org/uniprot/E8QWM3 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/575540:ISOP_RS16100 ^@ http://purl.uniprot.org/uniprot/E8R2T5 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/575540:ISOP_RS03565 ^@ http://purl.uniprot.org/uniprot/E8R157 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 20 kDa subunit family.|||Binds 1 [4Fe-4S] cluster.|||Cell inner membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/575540:ISOP_RS11440 ^@ http://purl.uniprot.org/uniprot/E8R4A6 ^@ Cofactor|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein. http://togogenome.org/gene/575540:ISOP_RS02950 ^@ http://purl.uniprot.org/uniprot/E8R026 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. http://togogenome.org/gene/575540:ISOP_RS12685 ^@ http://purl.uniprot.org/uniprot/E8R6M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS14450 ^@ http://purl.uniprot.org/uniprot/E8QZY3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/575540:ISOP_RS09075 ^@ http://purl.uniprot.org/uniprot/E8R0S9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/575540:ISOP_RS08495 ^@ http://purl.uniprot.org/uniprot/E8QZP1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/575540:ISOP_RS20700 ^@ http://purl.uniprot.org/uniprot/E8QY16 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS05240 ^@ http://purl.uniprot.org/uniprot/E8R3L0 ^@ Similarity ^@ Belongs to the carotenoid/retinoid oxidoreductase family. http://togogenome.org/gene/575540:ISOP_RS02485 ^@ http://purl.uniprot.org/uniprot/E8QZD5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/575540:ISOP_RS08785 ^@ http://purl.uniprot.org/uniprot/E8R098 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NDK family.|||Cytoplasm|||Homotetramer.|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/575540:ISOP_RS21220 ^@ http://purl.uniprot.org/uniprot/E8R123 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. http://togogenome.org/gene/575540:ISOP_RS17575 ^@ http://purl.uniprot.org/uniprot/E8R5A4 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/575540:ISOP_RS07340 ^@ http://purl.uniprot.org/uniprot/E8QXC3 ^@ Similarity ^@ Belongs to the peptidase M1 family. http://togogenome.org/gene/575540:ISOP_RS15345 ^@ http://purl.uniprot.org/uniprot/E8R1M2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the flotillin-like FloA family.|||Cell membrane|||Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.|||Homooligomerizes.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane raft http://togogenome.org/gene/575540:ISOP_RS16025 ^@ http://purl.uniprot.org/uniprot/E8R2S0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS06990 ^@ http://purl.uniprot.org/uniprot/E8QWK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gas vesicle GvpF/GvpL family.|||Gas vesicle|||Vesicle http://togogenome.org/gene/575540:ISOP_RS05540 ^@ http://purl.uniprot.org/uniprot/E8R445 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/575540:ISOP_RS18090 ^@ http://purl.uniprot.org/uniprot/E8R6P6 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/575540:ISOP_RS17600 ^@ http://purl.uniprot.org/uniprot/E8R5A8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell inner membrane|||Forms a complex with TatA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/575540:ISOP_RS08420 ^@ http://purl.uniprot.org/uniprot/E8QZM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/575540:ISOP_RS19610 ^@ http://purl.uniprot.org/uniprot/E8QZ91 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/575540:ISOP_RS07960 ^@ http://purl.uniprot.org/uniprot/E8QYU0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. http://togogenome.org/gene/575540:ISOP_RS16780 ^@ http://purl.uniprot.org/uniprot/E8R3Y2 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/575540:ISOP_RS16450 ^@ http://purl.uniprot.org/uniprot/E8R3D5 ^@ Function|||Similarity ^@ Belongs to the sigma-70 factor family.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. http://togogenome.org/gene/575540:ISOP_RS13995 ^@ http://purl.uniprot.org/uniprot/E8QZ45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS19055 ^@ http://purl.uniprot.org/uniprot/E8QXT4 ^@ Function|||Similarity ^@ Belongs to the RecO family.|||Involved in DNA repair and RecF pathway recombination. http://togogenome.org/gene/575540:ISOP_RS03670 ^@ http://purl.uniprot.org/uniprot/E8R177 ^@ Similarity ^@ Belongs to the anti-sigma-factor antagonist family. http://togogenome.org/gene/575540:ISOP_RS03330 ^@ http://purl.uniprot.org/uniprot/E8R0N3 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/575540:ISOP_RS15965 ^@ http://purl.uniprot.org/uniprot/E8R2R2 ^@ Caution|||Function|||Similarity ^@ Belongs to the RecR family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/575540:ISOP_RS18745 ^@ http://purl.uniprot.org/uniprot/E8QXM9 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/575540:ISOP_RS06235 ^@ http://purl.uniprot.org/uniprot/E8R5L1 ^@ Similarity ^@ Belongs to the UPF0301 (AlgH) family. http://togogenome.org/gene/575540:ISOP_RS11185 ^@ http://purl.uniprot.org/uniprot/E8R3S3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/575540:ISOP_RS16555 ^@ http://purl.uniprot.org/uniprot/E8R3F6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/575540:ISOP_RS06190 ^@ http://purl.uniprot.org/uniprot/E8R5K2 ^@ Function|||Similarity ^@ Belongs to the MqnA/MqnD family. MqnA subfamily.|||Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). http://togogenome.org/gene/575540:ISOP_RS06980 ^@ http://purl.uniprot.org/uniprot/E8QWK6 ^@ Similarity ^@ Belongs to the DNA polymerase type-Y family. http://togogenome.org/gene/575540:ISOP_RS08280 ^@ http://purl.uniprot.org/uniprot/E8QZ00 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 57 family. http://togogenome.org/gene/575540:ISOP_RS19115 ^@ http://purl.uniprot.org/uniprot/E8QYE9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS13865 ^@ http://purl.uniprot.org/uniprot/E8QZ18 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell inner membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Membrane|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/575540:ISOP_RS15010 ^@ http://purl.uniprot.org/uniprot/E8R126 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/575540:ISOP_RS02970 ^@ http://purl.uniprot.org/uniprot/E8R030 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase B chain family.|||Cell inner membrane|||Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Membrane http://togogenome.org/gene/575540:ISOP_RS00275 ^@ http://purl.uniprot.org/uniprot/E8R4R0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS03195 ^@ http://purl.uniprot.org/uniprot/E8R072 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS07730 ^@ http://purl.uniprot.org/uniprot/E8QY42 ^@ Similarity ^@ Belongs to the AlaDH/PNT family. http://togogenome.org/gene/575540:ISOP_RS11225 ^@ http://purl.uniprot.org/uniprot/E8R3T1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/575540:ISOP_RS03405 ^@ http://purl.uniprot.org/uniprot/E8R0P9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shikimate kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.|||Cytoplasm|||Monomer. http://togogenome.org/gene/575540:ISOP_RS19730 ^@ http://purl.uniprot.org/uniprot/E8QZA9 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/575540:ISOP_RS12225 ^@ http://purl.uniprot.org/uniprot/E8R5U3 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. http://togogenome.org/gene/575540:ISOP_RS16030 ^@ http://purl.uniprot.org/uniprot/E8R2S1 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/575540:ISOP_RS09465 ^@ http://purl.uniprot.org/uniprot/E8R1C8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer.|||In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.|||In the N-terminal section; belongs to the MIP18 family. http://togogenome.org/gene/575540:ISOP_RS02870 ^@ http://purl.uniprot.org/uniprot/E8QZK1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the anthranilate synthase component I family.|||Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).|||Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. http://togogenome.org/gene/575540:ISOP_RS05420 ^@ http://purl.uniprot.org/uniprot/E8R424 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/575540:ISOP_RS02960 ^@ http://purl.uniprot.org/uniprot/E8R028 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/575540:ISOP_RS00600 ^@ http://purl.uniprot.org/uniprot/E8R5G8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/575540:ISOP_RS18290 ^@ http://purl.uniprot.org/uniprot/E8R6T1 ^@ Caution|||Function|||Similarity ^@ Belongs to the MqnA/MqnD family. MqnD subfamily.|||Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS04235 ^@ http://purl.uniprot.org/uniprot/E8R1W7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the inorganic carbon transporter (TC 9.A.2) DabB family.|||Cell inner membrane|||Forms a complex with DabA.|||Membrane|||Part of an energy-coupled inorganic carbon pump. http://togogenome.org/gene/575540:ISOP_RS18210 ^@ http://purl.uniprot.org/uniprot/E8R6R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CpxP/Spy family.|||Periplasm http://togogenome.org/gene/575540:ISOP_RS17550 ^@ http://purl.uniprot.org/uniprot/E8R5A0 ^@ Similarity ^@ Belongs to the pyruvoyl-dependent arginine decarboxylase family. http://togogenome.org/gene/575540:ISOP_RS06025 ^@ http://purl.uniprot.org/uniprot/E8R4X5 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/575540:ISOP_RS09205 ^@ http://purl.uniprot.org/uniprot/E8R0V1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/575540:ISOP_RS15635 ^@ http://purl.uniprot.org/uniprot/E8R263 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerC subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/575540:ISOP_RS03620 ^@ http://purl.uniprot.org/uniprot/E8R167 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/575540:ISOP_RS18605 ^@ http://purl.uniprot.org/uniprot/E8QX01 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS18580 ^@ http://purl.uniprot.org/uniprot/E8QWZ5 ^@ Similarity ^@ Belongs to the UPF0234 family. http://togogenome.org/gene/575540:ISOP_RS12585 ^@ http://purl.uniprot.org/uniprot/E8R6K7 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/575540:ISOP_RS08500 ^@ http://purl.uniprot.org/uniprot/E8QZP2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/575540:ISOP_RS01720 ^@ http://purl.uniprot.org/uniprot/E8QX81 ^@ Function|||Similarity|||Subunit ^@ Belongs to the transferase hexapeptide repeat family. LpxD subfamily.|||Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.|||Homotrimer. http://togogenome.org/gene/575540:ISOP_RS07520 ^@ http://purl.uniprot.org/uniprot/E8QXF6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS14115 ^@ http://purl.uniprot.org/uniprot/E8QZS0 ^@ Caution|||Function|||PTM|||Similarity ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.|||Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS20410 ^@ http://purl.uniprot.org/uniprot/E8R0Q7 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/575540:ISOP_RS09690 ^@ http://purl.uniprot.org/uniprot/E8R1G3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/575540:ISOP_RS03025 ^@ http://purl.uniprot.org/uniprot/E8R040 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/575540:ISOP_RS15605 ^@ http://purl.uniprot.org/uniprot/E8R257 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS16700 ^@ http://purl.uniprot.org/uniprot/E8R3W5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell inner membrane|||Cytoplasm|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/575540:ISOP_RS03765 ^@ http://purl.uniprot.org/uniprot/E8R193 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ClpA/ClpB family.|||Cytoplasm|||Homohexamer. The oligomerization is ATP-dependent.|||Homohexamer; The oligomerization is ATP-dependent.|||Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. http://togogenome.org/gene/575540:ISOP_RS17025 ^@ http://purl.uniprot.org/uniprot/E8R4G4 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/575540:ISOP_RS18050 ^@ http://purl.uniprot.org/uniprot/E8R6N8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.|||Belongs to the CsrA/RsmA family.|||Cytoplasm|||Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core. http://togogenome.org/gene/575540:ISOP_RS19525 ^@ http://purl.uniprot.org/uniprot/E8QZ75 ^@ Function|||Similarity ^@ Belongs to the complex I 51 kDa subunit family.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. http://togogenome.org/gene/575540:ISOP_RS11305 ^@ http://purl.uniprot.org/uniprot/E8R480 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/575540:ISOP_RS14005 ^@ http://purl.uniprot.org/uniprot/E8QZ47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/575540:ISOP_RS10135 ^@ http://purl.uniprot.org/uniprot/E8R234 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS03740 ^@ http://purl.uniprot.org/uniprot/E8R189 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/575540:ISOP_RS08400 ^@ http://purl.uniprot.org/uniprot/E8QZM2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/575540:ISOP_RS19825 ^@ http://purl.uniprot.org/uniprot/E8QZC7 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/575540:ISOP_RS10965 ^@ http://purl.uniprot.org/uniprot/E8R3N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KdsA family.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS01095 ^@ http://purl.uniprot.org/uniprot/E8QWA8 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/575540:ISOP_RS12365 ^@ http://purl.uniprot.org/uniprot/E8R6G6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS12445 ^@ http://purl.uniprot.org/uniprot/E8R6I3 ^@ Similarity ^@ Belongs to the asparagine synthetase family. http://togogenome.org/gene/575540:ISOP_RS01465 ^@ http://purl.uniprot.org/uniprot/E8QX36 ^@ Similarity ^@ Belongs to the peptidase S41A family. http://togogenome.org/gene/575540:ISOP_RS07795 ^@ http://purl.uniprot.org/uniprot/E8QY55 ^@ Similarity ^@ Belongs to the prokaryotic GSH synthase family. http://togogenome.org/gene/575540:ISOP_RS14240 ^@ http://purl.uniprot.org/uniprot/E8QZU4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS06595 ^@ http://purl.uniprot.org/uniprot/E8R6C5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SelA family.|||Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS15075 ^@ http://purl.uniprot.org/uniprot/E8R137 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS11315 ^@ http://purl.uniprot.org/uniprot/E8R482 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/575540:ISOP_RS05965 ^@ http://purl.uniprot.org/uniprot/E8R4W3 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FBPase class 1 family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS18335 ^@ http://purl.uniprot.org/uniprot/E8R6T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DnaA family.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS01145 ^@ http://purl.uniprot.org/uniprot/E8QWC0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRA-CH family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/575540:ISOP_RS05535 ^@ http://purl.uniprot.org/uniprot/E8R444 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/575540:ISOP_RS07545 ^@ http://purl.uniprot.org/uniprot/E8QY12 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).|||Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS09040 ^@ http://purl.uniprot.org/uniprot/E8R0E1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/575540:ISOP_RS14970 ^@ http://purl.uniprot.org/uniprot/E8R119 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. http://togogenome.org/gene/575540:ISOP_RS03995 ^@ http://purl.uniprot.org/uniprot/E8R1R8 ^@ Similarity ^@ Belongs to the Skp family. http://togogenome.org/gene/575540:ISOP_RS12885 ^@ http://purl.uniprot.org/uniprot/E8QWS6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/575540:ISOP_RS17400 ^@ http://purl.uniprot.org/uniprot/E8R574 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.|||Cell inner membrane|||Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Membrane|||Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function. http://togogenome.org/gene/575540:ISOP_RS14920 ^@ http://purl.uniprot.org/uniprot/E8R109 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/575540:ISOP_RS19035 ^@ http://purl.uniprot.org/uniprot/E8QXT1 ^@ Function|||Similarity ^@ Belongs to the DHPS family.|||Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives. http://togogenome.org/gene/575540:ISOP_RS01140 ^@ http://purl.uniprot.org/uniprot/E8QWB9 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/575540:ISOP_RS13485 ^@ http://purl.uniprot.org/uniprot/E8QY95 ^@ Similarity ^@ Belongs to the peptidase S26 family. http://togogenome.org/gene/575540:ISOP_RS02060 ^@ http://purl.uniprot.org/uniprot/E8QY04 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/575540:ISOP_RS01885 ^@ http://purl.uniprot.org/uniprot/E8QXW9 ^@ Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate. http://togogenome.org/gene/575540:ISOP_RS06120 ^@ http://purl.uniprot.org/uniprot/E8R5J0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Binds 1 pyridoxal phosphate per subunit.|||Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS01590 ^@ http://purl.uniprot.org/uniprot/E8QX58 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the pyridoxamine 5'-phosphate oxidase family.|||Binds 1 FMN per subunit.|||Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).|||Homodimer. http://togogenome.org/gene/575540:ISOP_RS12815 ^@ http://purl.uniprot.org/uniprot/E8QWR5 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/575540:ISOP_RS01950 ^@ http://purl.uniprot.org/uniprot/E8QXY2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS16210 ^@ http://purl.uniprot.org/uniprot/E8R2V3 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the DnaG primase family.|||Binds 1 zinc ion per monomer.|||Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.|||Monomer. Interacts with DnaB.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/575540:ISOP_RS00450 ^@ http://purl.uniprot.org/uniprot/E8R5E1 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/575540:ISOP_RS08405 ^@ http://purl.uniprot.org/uniprot/E8QZM3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/575540:ISOP_RS01380 ^@ http://purl.uniprot.org/uniprot/E8QWG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/575540:ISOP_RS16085 ^@ http://purl.uniprot.org/uniprot/E8R2T2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/575540:ISOP_RS19015 ^@ http://purl.uniprot.org/uniprot/E8QXS7 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/575540:ISOP_RS04820 ^@ http://purl.uniprot.org/uniprot/E8R2Z4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Homotetramer.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/575540:ISOP_RS10190 ^@ http://purl.uniprot.org/uniprot/E8R2H6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MqnE family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. http://togogenome.org/gene/575540:ISOP_RS19490 ^@ http://purl.uniprot.org/uniprot/E8QZ68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4 family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS08690 ^@ http://purl.uniprot.org/uniprot/E8R082 ^@ Similarity ^@ Belongs to the bacterial microcompartments protein family. http://togogenome.org/gene/575540:ISOP_RS11260 ^@ http://purl.uniprot.org/uniprot/E8R3T8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/575540:ISOP_RS03140 ^@ http://purl.uniprot.org/uniprot/E8R062 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/575540:ISOP_RS07305 ^@ http://purl.uniprot.org/uniprot/E8QXB6 ^@ Function|||Similarity ^@ Belongs to the peptidase S46 family.|||Catalyzes the removal of dipeptides from the N-terminus of oligopeptides. http://togogenome.org/gene/575540:ISOP_RS08210 ^@ http://purl.uniprot.org/uniprot/E8QYY6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/575540:ISOP_RS20565 ^@ http://purl.uniprot.org/uniprot/E8R420 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/575540:ISOP_RS17360 ^@ http://purl.uniprot.org/uniprot/E8R568 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of glycine to tRNA(Gly).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/575540:ISOP_RS13745 ^@ http://purl.uniprot.org/uniprot/E8QYE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.|||Cell membrane|||Membrane http://togogenome.org/gene/575540:ISOP_RS12455 ^@ http://purl.uniprot.org/uniprot/E8R6I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FliQ/MopD/SpaQ family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS09315 ^@ http://purl.uniprot.org/uniprot/E8R0X1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS07365 ^@ http://purl.uniprot.org/uniprot/E8QXC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/575540:ISOP_RS07540 ^@ http://purl.uniprot.org/uniprot/E8QY11 ^@ Cofactor|||Similarity ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/575540:ISOP_RS07950 ^@ http://purl.uniprot.org/uniprot/E8QYT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS12335 ^@ http://purl.uniprot.org/uniprot/E8R5W3 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/575540:ISOP_RS13400 ^@ http://purl.uniprot.org/uniprot/E8QXM5 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/575540:ISOP_RS16740 ^@ http://purl.uniprot.org/uniprot/E8R3X3 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/575540:ISOP_RS08670 ^@ http://purl.uniprot.org/uniprot/E8R078 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/575540:ISOP_RS02540 ^@ http://purl.uniprot.org/uniprot/E8QZE5 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/575540:ISOP_RS12895 ^@ http://purl.uniprot.org/uniprot/E8QWS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Cell inner membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.|||Membrane http://togogenome.org/gene/575540:ISOP_RS08385 ^@ http://purl.uniprot.org/uniprot/E8QZL9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/575540:ISOP_RS20900 ^@ http://purl.uniprot.org/uniprot/E8R231 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the kinesin light chain family.|||cytoskeleton http://togogenome.org/gene/575540:ISOP_RS00775 ^@ http://purl.uniprot.org/uniprot/E8R640 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/575540:ISOP_RS09435 ^@ http://purl.uniprot.org/uniprot/E8R1C2 ^@ Function|||Similarity|||Subunit ^@ Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.|||Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.|||Homodimer.|||In the C-terminal section; belongs to the cytidylyltransferase family.|||In the N-terminal section; belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/575540:ISOP_RS19220 ^@ http://purl.uniprot.org/uniprot/E8QYG6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS20575 ^@ http://purl.uniprot.org/uniprot/E8R439 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS19495 ^@ http://purl.uniprot.org/uniprot/E8QZ69 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS11285 ^@ http://purl.uniprot.org/uniprot/E8R477 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/575540:ISOP_RS14340 ^@ http://purl.uniprot.org/uniprot/E8QZW3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvT family.|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/575540:ISOP_RS19240 ^@ http://purl.uniprot.org/uniprot/E8QYG9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS12450 ^@ http://purl.uniprot.org/uniprot/E8R6I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FliR/MopE/SpaR family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS20725 ^@ http://purl.uniprot.org/uniprot/E8QYV5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/575540:ISOP_RS17005 ^@ http://purl.uniprot.org/uniprot/E8R4G0 ^@ Caution|||Function|||Similarity ^@ Belongs to the DXR family.|||Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS06820 ^@ http://purl.uniprot.org/uniprot/E8QWH6 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/575540:ISOP_RS03775 ^@ http://purl.uniprot.org/uniprot/E8R194 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/575540:ISOP_RS20110 ^@ http://purl.uniprot.org/uniprot/E8R6W3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/575540:ISOP_RS07860 ^@ http://purl.uniprot.org/uniprot/E8QY68 ^@ Similarity ^@ Belongs to the SAM hydrolase / SAM-dependent halogenase family. http://togogenome.org/gene/575540:ISOP_RS16045 ^@ http://purl.uniprot.org/uniprot/E8R2S4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.|||Monomer and homodimer. http://togogenome.org/gene/575540:ISOP_RS13625 ^@ http://purl.uniprot.org/uniprot/E8QYC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS07240 ^@ http://purl.uniprot.org/uniprot/E8QXA4 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/575540:ISOP_RS04030 ^@ http://purl.uniprot.org/uniprot/E8R1S5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.|||Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS15495 ^@ http://purl.uniprot.org/uniprot/E8R1P9 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/575540:ISOP_RS02580 ^@ http://purl.uniprot.org/uniprot/E8QZF1 ^@ Similarity ^@ Belongs to the Dps family. http://togogenome.org/gene/575540:ISOP_RS05440 ^@ http://purl.uniprot.org/uniprot/E8R429 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6. http://togogenome.org/gene/575540:ISOP_RS14540 ^@ http://purl.uniprot.org/uniprot/E8R0G0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS20300 ^@ http://purl.uniprot.org/uniprot/E8QWD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS18850 ^@ http://purl.uniprot.org/uniprot/E8QXP7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase H family.|||Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Monomer. http://togogenome.org/gene/575540:ISOP_RS15200 ^@ http://purl.uniprot.org/uniprot/E8R1J4 ^@ Similarity ^@ Belongs to the peptidase M29 family. http://togogenome.org/gene/575540:ISOP_RS11955 ^@ http://purl.uniprot.org/uniprot/E8R543 ^@ Similarity ^@ Belongs to the adrenodoxin/putidaredoxin family. http://togogenome.org/gene/575540:ISOP_RS09910 ^@ http://purl.uniprot.org/uniprot/E8R1Z2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS05990 ^@ http://purl.uniprot.org/uniprot/E8R4W8 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/575540:ISOP_RS05980 ^@ http://purl.uniprot.org/uniprot/E8R4W6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PNT beta subunit family.|||Cell inner membrane|||Membrane|||The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. http://togogenome.org/gene/575540:ISOP_RS05920 ^@ http://purl.uniprot.org/uniprot/E8R4V4 ^@ Similarity ^@ Belongs to the archease family. http://togogenome.org/gene/575540:ISOP_RS13415 ^@ http://purl.uniprot.org/uniprot/E8QXM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the L/F-transferase family.|||Cytoplasm|||Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. http://togogenome.org/gene/575540:ISOP_RS14345 ^@ http://purl.uniprot.org/uniprot/E8QZW4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/575540:ISOP_RS18590 ^@ http://purl.uniprot.org/uniprot/E8QWZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyribonucleotide nucleotidyltransferase family.|||Cytoplasm|||Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. http://togogenome.org/gene/575540:ISOP_RS07885 ^@ http://purl.uniprot.org/uniprot/E8QY72 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS08685 ^@ http://purl.uniprot.org/uniprot/E8R081 ^@ Function|||Similarity ^@ Belongs to the PduL family.|||Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. http://togogenome.org/gene/575540:ISOP_RS15070 ^@ http://purl.uniprot.org/uniprot/E8R136 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/575540:ISOP_RS18660 ^@ http://purl.uniprot.org/uniprot/E8QX11 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Homotetramer. http://togogenome.org/gene/575540:ISOP_RS04610 ^@ http://purl.uniprot.org/uniprot/E8R2H3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Cell membrane|||Membrane|||Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). http://togogenome.org/gene/575540:ISOP_RS16110 ^@ http://purl.uniprot.org/uniprot/E8R2T7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS10535 ^@ http://purl.uniprot.org/uniprot/E8R2N9 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS00935 ^@ http://purl.uniprot.org/uniprot/E8R670 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/575540:ISOP_RS14595 ^@ http://purl.uniprot.org/uniprot/E8R0H1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/575540:ISOP_RS19295 ^@ http://purl.uniprot.org/uniprot/E8QYH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS14090 ^@ http://purl.uniprot.org/uniprot/E8QZ65 ^@ Similarity ^@ Belongs to the anti-sigma-factor antagonist family. http://togogenome.org/gene/575540:ISOP_RS19650 ^@ http://purl.uniprot.org/uniprot/E8QZ96 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/575540:ISOP_RS19710 ^@ http://purl.uniprot.org/uniprot/E8QZA6 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/575540:ISOP_RS19830 ^@ http://purl.uniprot.org/uniprot/E8QZC8 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily. http://togogenome.org/gene/575540:ISOP_RS07600 ^@ http://purl.uniprot.org/uniprot/E8QY19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS22510 ^@ http://purl.uniprot.org/uniprot/E8QYF8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS19655 ^@ http://purl.uniprot.org/uniprot/E8QZ97 ^@ Similarity ^@ Belongs to the TrpC family. http://togogenome.org/gene/575540:ISOP_RS03460 ^@ http://purl.uniprot.org/uniprot/E8R0R0 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. http://togogenome.org/gene/575540:ISOP_RS11205 ^@ http://purl.uniprot.org/uniprot/E8R3S7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/575540:ISOP_RS13255 ^@ http://purl.uniprot.org/uniprot/E8QXJ8 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/575540:ISOP_RS19865 ^@ http://purl.uniprot.org/uniprot/E8QZY7 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/575540:ISOP_RS11455 ^@ http://purl.uniprot.org/uniprot/E8R4A9 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/575540:ISOP_RS05890 ^@ http://purl.uniprot.org/uniprot/E8R4U9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PEP-utilizing enzyme family.|||Cytoplasm|||General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). http://togogenome.org/gene/575540:ISOP_RS14290 ^@ http://purl.uniprot.org/uniprot/E8QZV5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS15140 ^@ http://purl.uniprot.org/uniprot/E8R150 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 90 family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Molecular chaperone. Has ATPase activity. http://togogenome.org/gene/575540:ISOP_RS01810 ^@ http://purl.uniprot.org/uniprot/E8QXV4 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/575540:ISOP_RS02390 ^@ http://purl.uniprot.org/uniprot/E8QYR8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsX family.|||Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.|||Cytoplasm|||Homodimer. Probably interacts with PlsY. http://togogenome.org/gene/575540:ISOP_RS07770 ^@ http://purl.uniprot.org/uniprot/E8QY50 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lactate permease family.|||Cell membrane|||Membrane|||Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate. http://togogenome.org/gene/575540:ISOP_RS16680 ^@ http://purl.uniprot.org/uniprot/E8R3W1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/575540:ISOP_RS17220 ^@ http://purl.uniprot.org/uniprot/E8R4K0 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.|||Cytoplasm|||Homodimer or homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Non-allosteric. http://togogenome.org/gene/575540:ISOP_RS11180 ^@ http://purl.uniprot.org/uniprot/E8R3S2 ^@ Similarity ^@ Belongs to the LarC family. http://togogenome.org/gene/575540:ISOP_RS11310 ^@ http://purl.uniprot.org/uniprot/E8R481 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/575540:ISOP_RS11095 ^@ http://purl.uniprot.org/uniprot/E8R3Q8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate 5-kinase family.|||Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS10345 ^@ http://purl.uniprot.org/uniprot/E8R2K4 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/575540:ISOP_RS14400 ^@ http://purl.uniprot.org/uniprot/E8QZX4 ^@ Function|||Similarity ^@ Belongs to the NadD family.|||Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). http://togogenome.org/gene/575540:ISOP_RS00510 ^@ http://purl.uniprot.org/uniprot/E8R5F2 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||The C-terminal coiled-coil domain is crucial for aminoacylation activity.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/575540:ISOP_RS06615 ^@ http://purl.uniprot.org/uniprot/E8R6C9 ^@ Similarity ^@ Belongs to the hyi family. http://togogenome.org/gene/575540:ISOP_RS17605 ^@ http://purl.uniprot.org/uniprot/E8R5A9 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/575540:ISOP_RS08510 ^@ http://purl.uniprot.org/uniprot/E8QZP4 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS13935 ^@ http://purl.uniprot.org/uniprot/E8QZ34 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.|||Cytoplasm|||Homotetramer.|||Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.|||There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors. http://togogenome.org/gene/575540:ISOP_RS03105 ^@ http://purl.uniprot.org/uniprot/E8R056 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/575540:ISOP_RS10395 ^@ http://purl.uniprot.org/uniprot/E8R2L4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MnmG family.|||Cytoplasm|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. http://togogenome.org/gene/575540:ISOP_RS11245 ^@ http://purl.uniprot.org/uniprot/E8R3T5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/575540:ISOP_RS00490 ^@ http://purl.uniprot.org/uniprot/E8R5E8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/575540:ISOP_RS11340 ^@ http://purl.uniprot.org/uniprot/E8R487 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/575540:ISOP_RS03325 ^@ http://purl.uniprot.org/uniprot/E8R0N1 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/575540:ISOP_RS01510 ^@ http://purl.uniprot.org/uniprot/E8QX44 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/575540:ISOP_RS05695 ^@ http://purl.uniprot.org/uniprot/E8R474 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/575540:ISOP_RS03265 ^@ http://purl.uniprot.org/uniprot/E8R0L8 ^@ Function ^@ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. http://togogenome.org/gene/575540:ISOP_RS06040 ^@ http://purl.uniprot.org/uniprot/E8R4X7 ^@ Cofactor ^@ Binds 1 FAD per subunit. http://togogenome.org/gene/575540:ISOP_RS12870 ^@ http://purl.uniprot.org/uniprot/E8QWS5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/575540:ISOP_RS20445 ^@ http://purl.uniprot.org/uniprot/E8R1T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gas vesicle GvpK family.|||Gas vesicle|||Vesicle http://togogenome.org/gene/575540:ISOP_RS01530 ^@ http://purl.uniprot.org/uniprot/E8QX48 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/575540:ISOP_RS06500 ^@ http://purl.uniprot.org/uniprot/E8R6A8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/575540:ISOP_RS05800 ^@ http://purl.uniprot.org/uniprot/E8R4T4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. http://togogenome.org/gene/575540:ISOP_RS15445 ^@ http://purl.uniprot.org/uniprot/E8R1N9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/575540:ISOP_RS20495 ^@ http://purl.uniprot.org/uniprot/E8R2V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/575540:ISOP_RS08415 ^@ http://purl.uniprot.org/uniprot/E8QZM6 ^@ Similarity ^@ Belongs to the DapA family. http://togogenome.org/gene/575540:ISOP_RS09550 ^@ http://purl.uniprot.org/uniprot/E8R1E2 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/575540:ISOP_RS04475 ^@ http://purl.uniprot.org/uniprot/E8R2E8 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/575540:ISOP_RS08025 ^@ http://purl.uniprot.org/uniprot/E8QYV3 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/575540:ISOP_RS17615 ^@ http://purl.uniprot.org/uniprot/E8R5B1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS02020 ^@ http://purl.uniprot.org/uniprot/E8QXZ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YqgF HJR family.|||Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.|||Cytoplasm http://togogenome.org/gene/575540:ISOP_RS05605 ^@ http://purl.uniprot.org/uniprot/E8R457 ^@ Similarity ^@ Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. http://togogenome.org/gene/575540:ISOP_RS00505 ^@ http://purl.uniprot.org/uniprot/E8R5F1 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. http://togogenome.org/gene/575540:ISOP_RS03625 ^@ http://purl.uniprot.org/uniprot/E8R168 ^@ Similarity ^@ Belongs to the homoserine dehydrogenase family. http://togogenome.org/gene/575540:ISOP_RS15365 ^@ http://purl.uniprot.org/uniprot/E8R1M5 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/575540:ISOP_RS08515 ^@ http://purl.uniprot.org/uniprot/E8QZP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/575540:ISOP_RS10165 ^@ http://purl.uniprot.org/uniprot/E8R240 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the GTP cyclohydrolase II family.|||Binds 1 zinc ion per subunit.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.|||In the N-terminal section; belongs to the DHBP synthase family. http://togogenome.org/gene/575540:ISOP_RS02945 ^@ http://purl.uniprot.org/uniprot/E8R025 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/575540:ISOP_RS11690 ^@ http://purl.uniprot.org/uniprot/E8R4Z5 ^@ Function ^@ Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). http://togogenome.org/gene/575540:ISOP_RS01160 ^@ http://purl.uniprot.org/uniprot/E8QWC3 ^@ Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||GTPase that plays an essential role in the late steps of ribosome biogenesis. http://togogenome.org/gene/575540:ISOP_RS01075 ^@ http://purl.uniprot.org/uniprot/E8R696 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RlmN family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.|||Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. http://togogenome.org/gene/575540:ISOP_RS07295 ^@ http://purl.uniprot.org/uniprot/E8QXB4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DtxR/MntR family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/575540:ISOP_RS00240 ^@ http://purl.uniprot.org/uniprot/E8R4Q3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS12460 ^@ http://purl.uniprot.org/uniprot/E8R6I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FliP/MopC/SpaP family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS19300 ^@ http://purl.uniprot.org/uniprot/E8QYI0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/575540:ISOP_RS00230 ^@ http://purl.uniprot.org/uniprot/E8R4Q1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 1 lipoyl cofactor covalently.|||E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). http://togogenome.org/gene/575540:ISOP_RS09620 ^@ http://purl.uniprot.org/uniprot/E8R1F4 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/575540:ISOP_RS00315 ^@ http://purl.uniprot.org/uniprot/E8R5B7 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/575540:ISOP_RS08375 ^@ http://purl.uniprot.org/uniprot/E8QZL7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DNA gyrase inhibitor YacG family.|||Binds 1 zinc ion.|||Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.|||Interacts with GyrB. http://togogenome.org/gene/575540:ISOP_RS05710 ^@ http://purl.uniprot.org/uniprot/E8R4R8 ^@ Similarity ^@ Belongs to the ParB family. http://togogenome.org/gene/575540:ISOP_RS08470 ^@ http://purl.uniprot.org/uniprot/E8QZN7 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/575540:ISOP_RS18275 ^@ http://purl.uniprot.org/uniprot/E8R6S8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/575540:ISOP_RS16815 ^@ http://purl.uniprot.org/uniprot/E8R3Y9 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. http://togogenome.org/gene/575540:ISOP_RS05380 ^@ http://purl.uniprot.org/uniprot/E8R416 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.|||Binds 1 potassium ion per subunit.|||Cytoplasm|||Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/575540:ISOP_RS05480 ^@ http://purl.uniprot.org/uniprot/E8R434 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/575540:ISOP_RS09360 ^@ http://purl.uniprot.org/uniprot/E8R0X9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/575540:ISOP_RS01340 ^@ http://purl.uniprot.org/uniprot/E8QWF9 ^@ Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. http://togogenome.org/gene/575540:ISOP_RS17085 ^@ http://purl.uniprot.org/uniprot/E8R4H6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 6-phosphogluconate dehydrogenase family.|||Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.|||Homodimer. http://togogenome.org/gene/575540:ISOP_RS07290 ^@ http://purl.uniprot.org/uniprot/E8QXB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.|||Membrane http://togogenome.org/gene/575540:ISOP_RS02395 ^@ http://purl.uniprot.org/uniprot/E8QYR9 ^@ Similarity ^@ Belongs to the fabD family. http://togogenome.org/gene/575540:ISOP_RS19460 ^@ http://purl.uniprot.org/uniprot/E8QYK8 ^@ Similarity ^@ Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. http://togogenome.org/gene/575540:ISOP_RS09800 ^@ http://purl.uniprot.org/uniprot/E8R1I5 ^@ Similarity ^@ Belongs to the DprA/Smf family. http://togogenome.org/gene/575540:ISOP_RS13950 ^@ http://purl.uniprot.org/uniprot/E8QZ37 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family.