http://togogenome.org/gene/579137:METVU_RS01035 ^@ http://purl.uniprot.org/uniprot/C9RES4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/579137:METVU_RS04930 ^@ http://purl.uniprot.org/uniprot/C9RH15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 2 subfamily.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS07850 ^@ http://purl.uniprot.org/uniprot/C9RDQ9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the THI4 family.|||Homooctamer; tetramer of dimers.|||Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS06510 ^@ http://purl.uniprot.org/uniprot/C9RHX9 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/579137:METVU_RS00715 ^@ http://purl.uniprot.org/uniprot/C9REL1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyl-coenzyme M reductase beta subunit family.|||Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.|||Hexamer of two alpha, two beta, and two gamma chains.|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers. http://togogenome.org/gene/579137:METVU_RS04955 ^@ http://purl.uniprot.org/uniprot/C9RH20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS04095 ^@ http://purl.uniprot.org/uniprot/C9RGJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/579137:METVU_RS01720 ^@ http://purl.uniprot.org/uniprot/C9RF61 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/579137:METVU_RS02625 ^@ http://purl.uniprot.org/uniprot/C9RFN9 ^@ Function ^@ Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP. http://togogenome.org/gene/579137:METVU_RS07485 ^@ http://purl.uniprot.org/uniprot/C9RDJ6 ^@ Similarity ^@ Belongs to the phosphosulfolactate synthase family. http://togogenome.org/gene/579137:METVU_RS05555 ^@ http://purl.uniprot.org/uniprot/C9RHE2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS06695 ^@ http://purl.uniprot.org/uniprot/C9RI13 ^@ Function|||Similarity ^@ Belongs to the archaeal 6-HMPDK family.|||Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP). http://togogenome.org/gene/579137:METVU_RS06400 ^@ http://purl.uniprot.org/uniprot/C9RHV7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/579137:METVU_RS03530 ^@ http://purl.uniprot.org/uniprot/C9RG75 ^@ Similarity ^@ Belongs to the FldB/FldC dehydratase alpha/beta subunit family. http://togogenome.org/gene/579137:METVU_RS05250 ^@ http://purl.uniprot.org/uniprot/C9RH81 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAC-alpha family.|||Contacts the emerging nascent chain on the ribosome.|||Homodimer. Interacts with the ribosome. Binds ribosomal RNA. http://togogenome.org/gene/579137:METVU_RS00735 ^@ http://purl.uniprot.org/uniprot/C9REL5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the methyl-coenzyme M reductase alpha subunit family.|||Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.|||Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.|||Hexamer of two alpha, two beta, and two gamma chains.|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers. http://togogenome.org/gene/579137:METVU_RS07840 ^@ http://purl.uniprot.org/uniprot/C9RDQ7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. Probably involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.|||Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA. http://togogenome.org/gene/579137:METVU_RS01905 ^@ http://purl.uniprot.org/uniprot/C9RF97 ^@ Similarity ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. http://togogenome.org/gene/579137:METVU_RS06235 ^@ http://purl.uniprot.org/uniprot/C9RHS4 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. http://togogenome.org/gene/579137:METVU_RS07105 ^@ http://purl.uniprot.org/uniprot/C9RI99 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/579137:METVU_RS05405 ^@ http://purl.uniprot.org/uniprot/C9RHB2 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/579137:METVU_RS04990 ^@ http://purl.uniprot.org/uniprot/C9RH27 ^@ Similarity ^@ Belongs to the UPF0282 family. http://togogenome.org/gene/579137:METVU_RS07600 ^@ http://purl.uniprot.org/uniprot/C9RDL9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.|||Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure. http://togogenome.org/gene/579137:METVU_RS08390 ^@ http://purl.uniprot.org/uniprot/C9RE14 ^@ Similarity ^@ Belongs to the transcriptional regulatory CopG/NikR family. http://togogenome.org/gene/579137:METVU_RS04800 ^@ http://purl.uniprot.org/uniprot/C9RGY9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS06810 ^@ http://purl.uniprot.org/uniprot/C9RI41 ^@ Similarity ^@ Belongs to the UPF0128 family. http://togogenome.org/gene/579137:METVU_RS04965 ^@ http://purl.uniprot.org/uniprot/C9RH22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS01310 ^@ http://purl.uniprot.org/uniprot/C9REY0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.|||Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.|||Homodimer. http://togogenome.org/gene/579137:METVU_RS06370 ^@ http://purl.uniprot.org/uniprot/C9RHV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS02575 ^@ http://purl.uniprot.org/uniprot/C9RFM9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/579137:METVU_RS08230 ^@ http://purl.uniprot.org/uniprot/C9RDY3 ^@ Similarity ^@ Belongs to the MoaB/Mog family. http://togogenome.org/gene/579137:METVU_RS04585 ^@ http://purl.uniprot.org/uniprot/C9RGU5 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/579137:METVU_RS05500 ^@ http://purl.uniprot.org/uniprot/C9RHD1 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the MRE11/RAD32 family.|||Binds 2 manganese ions per subunit.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Nuclease activity is regulated by Rad50.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. http://togogenome.org/gene/579137:METVU_RS00045 ^@ http://purl.uniprot.org/uniprot/C9RE80 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/579137:METVU_RS00255 ^@ http://purl.uniprot.org/uniprot/C9REC0 ^@ Similarity ^@ Belongs to the UPF0212 family. http://togogenome.org/gene/579137:METVU_RS01545 ^@ http://purl.uniprot.org/uniprot/C9RF30 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS00860 ^@ http://purl.uniprot.org/uniprot/C9REN9 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. http://togogenome.org/gene/579137:METVU_RS03000 ^@ http://purl.uniprot.org/uniprot/C9RFX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/579137:METVU_RS02555 ^@ http://purl.uniprot.org/uniprot/C9RFM5 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/579137:METVU_RS01045 ^@ http://purl.uniprot.org/uniprot/C9RES6 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Part of the 30S ribosomal subunit. Contacts protein S4.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/579137:METVU_RS02020 ^@ http://purl.uniprot.org/uniprot/C9RFB8 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. http://togogenome.org/gene/579137:METVU_RS07175 ^@ http://purl.uniprot.org/uniprot/C9RIB3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TYW1 family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).|||Cytoplasm|||Monomer. http://togogenome.org/gene/579137:METVU_RS06485 ^@ http://purl.uniprot.org/uniprot/C9RHX4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS06155 ^@ http://purl.uniprot.org/uniprot/C9RHQ8 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/579137:METVU_RS03980 ^@ http://purl.uniprot.org/uniprot/C9RGH0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/579137:METVU_RS05530 ^@ http://purl.uniprot.org/uniprot/C9RHD7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Membrane http://togogenome.org/gene/579137:METVU_RS04385 ^@ http://purl.uniprot.org/uniprot/C9RGQ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyltransferase superfamily. Fibrillarin family.|||Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.|||Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. http://togogenome.org/gene/579137:METVU_RS06035 ^@ http://purl.uniprot.org/uniprot/C9RHN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA-PH family.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS01460 ^@ http://purl.uniprot.org/uniprot/C9RF11 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS01315 ^@ http://purl.uniprot.org/uniprot/C9REY1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the BioW family.|||Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.|||Homodimer. http://togogenome.org/gene/579137:METVU_RS08775 ^@ http://purl.uniprot.org/uniprot/C9RIH4 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/579137:METVU_RS05665 ^@ http://purl.uniprot.org/uniprot/C9RHG4 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/579137:METVU_RS07395 ^@ http://purl.uniprot.org/uniprot/C9RIF5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/579137:METVU_RS03610 ^@ http://purl.uniprot.org/uniprot/C9RG91 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. RfcS subfamily. http://togogenome.org/gene/579137:METVU_RS03205 ^@ http://purl.uniprot.org/uniprot/C9RG14 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/579137:METVU_RS06160 ^@ http://purl.uniprot.org/uniprot/C9RHQ9 ^@ Function|||Similarity ^@ Belongs to the 2-phosphoglycerate kinase family.|||Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant. http://togogenome.org/gene/579137:METVU_RS03170 ^@ http://purl.uniprot.org/uniprot/C9RG06 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS07150 ^@ http://purl.uniprot.org/uniprot/C9RIA8 ^@ Similarity ^@ Belongs to the NodU/CmcH family. http://togogenome.org/gene/579137:METVU_RS07100 ^@ http://purl.uniprot.org/uniprot/C9RI98 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.|||Heterooligomer of catalytic and regulatory chains. http://togogenome.org/gene/579137:METVU_RS05615 ^@ http://purl.uniprot.org/uniprot/C9RHF4 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated Csm2 family.|||This subunit may be involved in monitoring complementarity of crRNA and target RNA. http://togogenome.org/gene/579137:METVU_RS08090 ^@ http://purl.uniprot.org/uniprot/C9RDV6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/579137:METVU_RS02265 ^@ http://purl.uniprot.org/uniprot/C9RFG5 ^@ Function|||Similarity ^@ Belongs to the SepSecS family.|||Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. http://togogenome.org/gene/579137:METVU_RS02460 ^@ http://purl.uniprot.org/uniprot/C9RFK6 ^@ Cofactor|||Similarity ^@ Belongs to the PdaD family.|||Binds 1 pyruvoyl group covalently per subunit. http://togogenome.org/gene/579137:METVU_RS01925 ^@ http://purl.uniprot.org/uniprot/C9RFA1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/579137:METVU_RS01060 ^@ http://purl.uniprot.org/uniprot/C9RES9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/579137:METVU_RS06670 ^@ http://purl.uniprot.org/uniprot/C9RI08 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type-I 3-dehydroquinase family.|||Homodimer.|||Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS06220 ^@ http://purl.uniprot.org/uniprot/C9RHS2 ^@ Function|||Similarity ^@ Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.|||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/579137:METVU_RS03940 ^@ http://purl.uniprot.org/uniprot/C9RGG1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecF subfamily.|||Cell membrane|||Involved in protein export.|||Membrane|||Part of the protein translocation apparatus. Forms a complex with SecD. http://togogenome.org/gene/579137:METVU_RS03560 ^@ http://purl.uniprot.org/uniprot/C9RG81 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/579137:METVU_RS06980 ^@ http://purl.uniprot.org/uniprot/C9RI75 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/579137:METVU_RS02615 ^@ http://purl.uniprot.org/uniprot/C9RFN7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NadC/ModD family.|||Hexamer formed by 3 homodimers.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/579137:METVU_RS08195 ^@ http://purl.uniprot.org/uniprot/C9RDX6 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/579137:METVU_RS01080 ^@ http://purl.uniprot.org/uniprot/C9RET3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/579137:METVU_RS06630 ^@ http://purl.uniprot.org/uniprot/C9RI00 ^@ Subunit ^@ Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/579137:METVU_RS08265 ^@ http://purl.uniprot.org/uniprot/C9RDZ0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.|||Monomer.|||The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity. http://togogenome.org/gene/579137:METVU_RS03900 ^@ http://purl.uniprot.org/uniprot/C9RGF3 ^@ Similarity ^@ Belongs to the FwdC/FmdC family. http://togogenome.org/gene/579137:METVU_RS02010 ^@ http://purl.uniprot.org/uniprot/C9RFB6 ^@ Function ^@ Part of a potassium transport system. http://togogenome.org/gene/579137:METVU_RS01265 ^@ http://purl.uniprot.org/uniprot/C9REX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family.|||Membrane http://togogenome.org/gene/579137:METVU_RS06560 ^@ http://purl.uniprot.org/uniprot/C9RHY8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL24 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14. http://togogenome.org/gene/579137:METVU_RS04045 ^@ http://purl.uniprot.org/uniprot/C9RGI3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal dihydroneopterin aldolase family.|||Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).|||Homotetramer. http://togogenome.org/gene/579137:METVU_RS04205 ^@ http://purl.uniprot.org/uniprot/C9RGL5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal DNA polymerase II family.|||Heterodimer of a large subunit and a small subunit.|||Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. http://togogenome.org/gene/579137:METVU_RS06450 ^@ http://purl.uniprot.org/uniprot/C9RHW7 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruD family.|||Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs. http://togogenome.org/gene/579137:METVU_RS02660 ^@ http://purl.uniprot.org/uniprot/C9RFP7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS01455 ^@ http://purl.uniprot.org/uniprot/C9RF10 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/579137:METVU_RS03985 ^@ http://purl.uniprot.org/uniprot/C9RGH1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/579137:METVU_RS08200 ^@ http://purl.uniprot.org/uniprot/C9RDX7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/579137:METVU_RS04785 ^@ http://purl.uniprot.org/uniprot/C9RGY6 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/579137:METVU_RS00940 ^@ http://purl.uniprot.org/uniprot/C9REQ5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/579137:METVU_RS06990 ^@ http://purl.uniprot.org/uniprot/C9RI77 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/579137:METVU_RS03355 ^@ http://purl.uniprot.org/uniprot/C9RG40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||Cytoplasm|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/579137:METVU_RS03235 ^@ http://purl.uniprot.org/uniprot/C9RG20 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/579137:METVU_RS00160 ^@ http://purl.uniprot.org/uniprot/C9REA2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/579137:METVU_RS02275 ^@ http://purl.uniprot.org/uniprot/C9RFG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Cell membrane|||Membrane http://togogenome.org/gene/579137:METVU_RS06365 ^@ http://purl.uniprot.org/uniprot/C9RHV0 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/579137:METVU_RS04280 ^@ http://purl.uniprot.org/uniprot/C9RGN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Cytoplasm|||Functions by promoting the formation of the first peptide bond. http://togogenome.org/gene/579137:METVU_RS08485 ^@ http://purl.uniprot.org/uniprot/C9RE32 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/579137:METVU_RS03330 ^@ http://purl.uniprot.org/uniprot/C9RG35 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS04950 ^@ http://purl.uniprot.org/uniprot/C9RH19 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/579137:METVU_RS07755 ^@ http://purl.uniprot.org/uniprot/C9RDN9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/579137:METVU_RS08650 ^@ http://purl.uniprot.org/uniprot/C9RE63 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/579137:METVU_RS06865 ^@ http://purl.uniprot.org/uniprot/C9RI52 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/579137:METVU_RS01205 ^@ http://purl.uniprot.org/uniprot/C9REV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/579137:METVU_RS01070 ^@ http://purl.uniprot.org/uniprot/C9RET1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/579137:METVU_RS05520 ^@ http://purl.uniprot.org/uniprot/C9RHD5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS04750 ^@ http://purl.uniprot.org/uniprot/C9RGX9 ^@ Function|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro. http://togogenome.org/gene/579137:METVU_RS01840 ^@ http://purl.uniprot.org/uniprot/C9RF85 ^@ Subunit ^@ Homotetramer. http://togogenome.org/gene/579137:METVU_RS04375 ^@ http://purl.uniprot.org/uniprot/C9RGQ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/579137:METVU_RS05865 ^@ http://purl.uniprot.org/uniprot/C9RHK2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-alpha family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/579137:METVU_RS07495 ^@ http://purl.uniprot.org/uniprot/C9RDJ8 ^@ Function|||Similarity ^@ Belongs to the CbiD family.|||Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. http://togogenome.org/gene/579137:METVU_RS01175 ^@ http://purl.uniprot.org/uniprot/C9REV2 ^@ Similarity ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/579137:METVU_RS08570 ^@ http://purl.uniprot.org/uniprot/C9RE48 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the QueC family.|||Binds 1 zinc ion per subunit.|||Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). http://togogenome.org/gene/579137:METVU_RS04560 ^@ http://purl.uniprot.org/uniprot/C9RGT9 ^@ Similarity ^@ Belongs to the HsdR family. http://togogenome.org/gene/579137:METVU_RS08025 ^@ http://purl.uniprot.org/uniprot/C9RDU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of glycine to tRNA(Gly).|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS00370 ^@ http://purl.uniprot.org/uniprot/C9REE4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS08255 ^@ http://purl.uniprot.org/uniprot/C9RDY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.|||Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS01770 ^@ http://purl.uniprot.org/uniprot/C9RF70 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/579137:METVU_RS08055 ^@ http://purl.uniprot.org/uniprot/C9RDV0 ^@ Similarity ^@ Belongs to the HupF/HypC family. http://togogenome.org/gene/579137:METVU_RS03140 ^@ http://purl.uniprot.org/uniprot/C9RG00 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. http://togogenome.org/gene/579137:METVU_RS05870 ^@ http://purl.uniprot.org/uniprot/C9RHK3 ^@ Function|||Similarity ^@ Belongs to the NOP10 family.|||Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. http://togogenome.org/gene/579137:METVU_RS05435 ^@ http://purl.uniprot.org/uniprot/C9RHB8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS08795 ^@ http://purl.uniprot.org/uniprot/C9RIH8 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/579137:METVU_RS01765 ^@ http://purl.uniprot.org/uniprot/C9RF69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS06870 ^@ http://purl.uniprot.org/uniprot/C9RI53 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.|||Cytoplasm|||May catalyze the biosynthesis of dTMP using an unknown cosubstrate.|||Monomer. http://togogenome.org/gene/579137:METVU_RS04275 ^@ http://purl.uniprot.org/uniprot/C9RGN0 ^@ Similarity ^@ Belongs to the organic radical-activating enzymes family. http://togogenome.org/gene/579137:METVU_RS07820 ^@ http://purl.uniprot.org/uniprot/C9RDQ3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/579137:METVU_RS05930 ^@ http://purl.uniprot.org/uniprot/C9RHL5 ^@ Similarity|||Subunit ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.|||Homotetramer; probably dimer of dimers. http://togogenome.org/gene/579137:METVU_RS03505 ^@ http://purl.uniprot.org/uniprot/C9RG70 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HdrA family.|||Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).|||The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC. http://togogenome.org/gene/579137:METVU_RS00425 ^@ http://purl.uniprot.org/uniprot/C9REF5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CofC family.|||Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.|||Homodimer. http://togogenome.org/gene/579137:METVU_RS06860 ^@ http://purl.uniprot.org/uniprot/C9RI51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/579137:METVU_RS00600 ^@ http://purl.uniprot.org/uniprot/C9REI9 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS06110 ^@ http://purl.uniprot.org/uniprot/C9RHP9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS05810 ^@ http://purl.uniprot.org/uniprot/C9RHJ1 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/579137:METVU_RS07460 ^@ http://purl.uniprot.org/uniprot/C9RDJ1 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/579137:METVU_RS05840 ^@ http://purl.uniprot.org/uniprot/C9RHJ7 ^@ Similarity ^@ Belongs to the transcriptional regulatory CopG/NikR family. http://togogenome.org/gene/579137:METVU_RS01065 ^@ http://purl.uniprot.org/uniprot/C9RET0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/579137:METVU_RS08010 ^@ http://purl.uniprot.org/uniprot/C9RDU1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/579137:METVU_RS05625 ^@ http://purl.uniprot.org/uniprot/C9RHF6 ^@ Similarity ^@ Belongs to the CRISPR-associated Csm4 family. http://togogenome.org/gene/579137:METVU_RS01110 ^@ http://purl.uniprot.org/uniprot/C9RET9 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/579137:METVU_RS04270 ^@ http://purl.uniprot.org/uniprot/C9RGM9 ^@ Similarity ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. http://togogenome.org/gene/579137:METVU_RS01835 ^@ http://purl.uniprot.org/uniprot/C9RF84 ^@ Similarity ^@ Belongs to the UPF0147 family. http://togogenome.org/gene/579137:METVU_RS06240 ^@ http://purl.uniprot.org/uniprot/C9RHS5 ^@ Similarity ^@ In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/579137:METVU_RS08725 ^@ http://purl.uniprot.org/uniprot/C9RE71 ^@ Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/579137:METVU_RS02680 ^@ http://purl.uniprot.org/uniprot/C9RFQ1 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/579137:METVU_RS02635 ^@ http://purl.uniprot.org/uniprot/C9RFP1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.|||Belongs to the Holliday junction resolvase Hjc family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer. http://togogenome.org/gene/579137:METVU_RS03150 ^@ http://purl.uniprot.org/uniprot/C9RG02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S16 family.|||Membrane http://togogenome.org/gene/579137:METVU_RS06850 ^@ http://purl.uniprot.org/uniprot/C9RI49 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family.|||Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. http://togogenome.org/gene/579137:METVU_RS01115 ^@ http://purl.uniprot.org/uniprot/C9REU0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/579137:METVU_RS03015 ^@ http://purl.uniprot.org/uniprot/C9RFX5 ^@ Similarity ^@ Belongs to the archaeosine synthase type 1 family. http://togogenome.org/gene/579137:METVU_RS02655 ^@ http://purl.uniprot.org/uniprot/C9RFP6 ^@ Similarity ^@ Belongs to the UPF0305 family. http://togogenome.org/gene/579137:METVU_RS05880 ^@ http://purl.uniprot.org/uniprot/C9RHK5 ^@ Similarity ^@ Belongs to the UPF0248 family. http://togogenome.org/gene/579137:METVU_RS03120 ^@ http://purl.uniprot.org/uniprot/C9RFZ6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ThiC family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. http://togogenome.org/gene/579137:METVU_RS02430 ^@ http://purl.uniprot.org/uniprot/C9RFK0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DHBP synthase family.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Homodimer. http://togogenome.org/gene/579137:METVU_RS04055 ^@ http://purl.uniprot.org/uniprot/C9RGI5 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/579137:METVU_RS07655 ^@ http://purl.uniprot.org/uniprot/C9RDN0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycerol-1-phosphate dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS03725 ^@ http://purl.uniprot.org/uniprot/C9RGB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/579137:METVU_RS00770 ^@ http://purl.uniprot.org/uniprot/C9REM2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrG family.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/579137:METVU_RS04325 ^@ http://purl.uniprot.org/uniprot/C9RGP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS04710 ^@ http://purl.uniprot.org/uniprot/C9RGX1 ^@ Cofactor|||Similarity ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/579137:METVU_RS03265 ^@ http://purl.uniprot.org/uniprot/C9RG23 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS05155 ^@ http://purl.uniprot.org/uniprot/C9RH61 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/579137:METVU_RS07650 ^@ http://purl.uniprot.org/uniprot/C9RDM9 ^@ Similarity ^@ Belongs to the carbamoyltransferase HypF family. http://togogenome.org/gene/579137:METVU_RS04440 ^@ http://purl.uniprot.org/uniprot/C9RGR5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GGGP/HepGP synthase family. Group II subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/579137:METVU_RS01020 ^@ http://purl.uniprot.org/uniprot/C9RES1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS01615 ^@ http://purl.uniprot.org/uniprot/C9RF44 ^@ Similarity ^@ Belongs to the archaeal ATPase family. http://togogenome.org/gene/579137:METVU_RS01370 ^@ http://purl.uniprot.org/uniprot/C9REZ2 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/579137:METVU_RS08275 ^@ http://purl.uniprot.org/uniprot/C9RDZ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e. http://togogenome.org/gene/579137:METVU_RS05850 ^@ http://purl.uniprot.org/uniprot/C9RHJ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyl-coenzyme M reductase gamma subunit family.|||Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.|||Hexamer of two alpha, two beta, and two gamma chains.|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers. http://togogenome.org/gene/579137:METVU_RS02725 ^@ http://purl.uniprot.org/uniprot/C9RFR2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS1 family. http://togogenome.org/gene/579137:METVU_RS07085 ^@ http://purl.uniprot.org/uniprot/C9RI95 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. http://togogenome.org/gene/579137:METVU_RS06380 ^@ http://purl.uniprot.org/uniprot/C9RHV3 ^@ Function|||Similarity ^@ Belongs to the adenylate cyclase family. DacZ subfamily.|||Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. http://togogenome.org/gene/579137:METVU_RS07900 ^@ http://purl.uniprot.org/uniprot/C9RDR9 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/579137:METVU_RS04715 ^@ http://purl.uniprot.org/uniprot/C9RGX2 ^@ Similarity|||Subunit ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family.|||Homodimer. http://togogenome.org/gene/579137:METVU_RS06475 ^@ http://purl.uniprot.org/uniprot/C9RHX2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS05570 ^@ http://purl.uniprot.org/uniprot/C9RHE5 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/579137:METVU_RS02590 ^@ http://purl.uniprot.org/uniprot/C9RFN2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family.|||Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.|||Homodimer. http://togogenome.org/gene/579137:METVU_RS01390 ^@ http://purl.uniprot.org/uniprot/C9REZ6 ^@ Similarity ^@ Belongs to the HdrC family. http://togogenome.org/gene/579137:METVU_RS05820 ^@ http://purl.uniprot.org/uniprot/C9RHJ3 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the Ni-containing carbon monoxide dehydrogenase family.|||Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.|||Binds 7 [4Fe-4S] clusters per heterotetramer.|||Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.|||Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).|||Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. http://togogenome.org/gene/579137:METVU_RS01700 ^@ http://purl.uniprot.org/uniprot/C9RF57 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/579137:METVU_RS02315 ^@ http://purl.uniprot.org/uniprot/C9RFH7 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.|||Binds 1 FAD per subunit.|||Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.|||Reduction reaction proceeds via syn addition of hydrogen for double bonds. http://togogenome.org/gene/579137:METVU_RS01810 ^@ http://purl.uniprot.org/uniprot/C9RF79 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/579137:METVU_RS00495 ^@ http://purl.uniprot.org/uniprot/C9REG9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/579137:METVU_RS04805 ^@ http://purl.uniprot.org/uniprot/C9RGZ0 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.|||Belongs to the RuBisCO large chain family. Type III subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.|||Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits. http://togogenome.org/gene/579137:METVU_RS06145 ^@ http://purl.uniprot.org/uniprot/C9RHQ6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/579137:METVU_RS00850 ^@ http://purl.uniprot.org/uniprot/C9REN7 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/579137:METVU_RS00455 ^@ http://purl.uniprot.org/uniprot/C9REG1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Archaeal flagellum|||Belongs to the archaeal flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella. http://togogenome.org/gene/579137:METVU_RS01785 ^@ http://purl.uniprot.org/uniprot/C9RF74 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. http://togogenome.org/gene/579137:METVU_RS04830 ^@ http://purl.uniprot.org/uniprot/C9RGZ5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/579137:METVU_RS01085 ^@ http://purl.uniprot.org/uniprot/C9RET4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/579137:METVU_RS03820 ^@ http://purl.uniprot.org/uniprot/C9RGD7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 15 family. http://togogenome.org/gene/579137:METVU_RS06785 ^@ http://purl.uniprot.org/uniprot/C9RI36 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcL subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/579137:METVU_RS07120 ^@ http://purl.uniprot.org/uniprot/C9RIA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transaldolase family. Type 3B subfamily.|||Cytoplasm|||Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. http://togogenome.org/gene/579137:METVU_RS06410 ^@ http://purl.uniprot.org/uniprot/C9RHV9 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/579137:METVU_RS07235 ^@ http://purl.uniprot.org/uniprot/C9RIC3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Spt4 family.|||Heterodimer composed of Spt4 and Spt5.|||Stimulates transcription elongation. http://togogenome.org/gene/579137:METVU_RS00265 ^@ http://purl.uniprot.org/uniprot/C9REC2 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SIS family. GmhA subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.|||Cytoplasm|||The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate. http://togogenome.org/gene/579137:METVU_RS01695 ^@ http://purl.uniprot.org/uniprot/C9RF56 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/579137:METVU_RS06835 ^@ http://purl.uniprot.org/uniprot/C9RI46 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/579137:METVU_RS01260 ^@ http://purl.uniprot.org/uniprot/C9REW9 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/579137:METVU_RS05805 ^@ http://purl.uniprot.org/uniprot/C9RHJ0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the CdhC family.|||Binds 1 [Ni-Fe-S] cluster.|||Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).|||Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex). http://togogenome.org/gene/579137:METVU_RS08655 ^@ http://purl.uniprot.org/uniprot/C9RE64 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/579137:METVU_RS00900 ^@ http://purl.uniprot.org/uniprot/C9REP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/579137:METVU_RS01190 ^@ http://purl.uniprot.org/uniprot/C9REV5 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/579137:METVU_RS03425 ^@ http://purl.uniprot.org/uniprot/C9RG54 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the asparaginase 1 family. GatD subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/579137:METVU_RS05285 ^@ http://purl.uniprot.org/uniprot/C9RH88 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/579137:METVU_RS01885 ^@ http://purl.uniprot.org/uniprot/C9RF93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/579137:METVU_RS05165 ^@ http://purl.uniprot.org/uniprot/C9RH63 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS02190 ^@ http://purl.uniprot.org/uniprot/C9RFF0 ^@ Similarity ^@ Belongs to the HdrC family. http://togogenome.org/gene/579137:METVU_RS07960 ^@ http://purl.uniprot.org/uniprot/C9RDT2 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. http://togogenome.org/gene/579137:METVU_RS01485 ^@ http://purl.uniprot.org/uniprot/C9RF16 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP19 family.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/579137:METVU_RS02470 ^@ http://purl.uniprot.org/uniprot/C9RFK8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the spermidine/spermine synthase family.|||Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.|||Homodimer or homotetramer. http://togogenome.org/gene/579137:METVU_RS02650 ^@ http://purl.uniprot.org/uniprot/C9RFP4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin alpha subunit family.|||Belongs to the prefoldin subunit alpha family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/579137:METVU_RS00755 ^@ http://purl.uniprot.org/uniprot/C9REL9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrB family.|||Cell membrane|||Membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/579137:METVU_RS08080 ^@ http://purl.uniprot.org/uniprot/C9RDV4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/579137:METVU_RS07420 ^@ http://purl.uniprot.org/uniprot/C9RIG0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS03655 ^@ http://purl.uniprot.org/uniprot/C9RGA0 ^@ Similarity ^@ Belongs to the LarC family. http://togogenome.org/gene/579137:METVU_RS03075 ^@ http://purl.uniprot.org/uniprot/C9RFY7 ^@ Similarity ^@ Belongs to the FrhG family. http://togogenome.org/gene/579137:METVU_RS00805 ^@ http://purl.uniprot.org/uniprot/C9REM8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS02705 ^@ http://purl.uniprot.org/uniprot/C9RFQ6 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. UPF0219 family. http://togogenome.org/gene/579137:METVU_RS01155 ^@ http://purl.uniprot.org/uniprot/C9REU8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Homodimer.|||Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. http://togogenome.org/gene/579137:METVU_RS04615 ^@ http://purl.uniprot.org/uniprot/C9RGV1 ^@ Function|||Similarity ^@ Belongs to the PEP-utilizing enzyme family.|||Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. http://togogenome.org/gene/579137:METVU_RS03740 ^@ http://purl.uniprot.org/uniprot/C9RGB7 ^@ Domain|||Function|||Miscellaneous|||Similarity ^@ Belongs to the CobB/CbiA family.|||Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.|||Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.|||The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate. http://togogenome.org/gene/579137:METVU_RS01580 ^@ http://purl.uniprot.org/uniprot/C9RF37 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS03640 ^@ http://purl.uniprot.org/uniprot/C9RG97 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRA-CH family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/579137:METVU_RS03625 ^@ http://purl.uniprot.org/uniprot/C9RG94 ^@ Similarity ^@ Belongs to the LDH2/MDH2 oxidoreductase family. http://togogenome.org/gene/579137:METVU_RS00135 ^@ http://purl.uniprot.org/uniprot/C9RE97 ^@ Function|||Similarity ^@ Belongs to the HMD family.|||Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. http://togogenome.org/gene/579137:METVU_RS06010 ^@ http://purl.uniprot.org/uniprot/C9RHN0 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated Csm5 family.|||This subunit might be involved in maturation of a crRNA intermediate to its mature form. http://togogenome.org/gene/579137:METVU_RS02670 ^@ http://purl.uniprot.org/uniprot/C9RFP9 ^@ Similarity|||Subunit ^@ Belongs to the ALAD family.|||Homooctamer. http://togogenome.org/gene/579137:METVU_RS06565 ^@ http://purl.uniprot.org/uniprot/C9RHY9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/579137:METVU_RS00415 ^@ http://purl.uniprot.org/uniprot/C9REF3 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/579137:METVU_RS03440 ^@ http://purl.uniprot.org/uniprot/C9RG57 ^@ Function|||Similarity|||Subunit ^@ Belongs to the OMP decarboxylase family. Type 1 subfamily.|||Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).|||Homodimer. http://togogenome.org/gene/579137:METVU_RS04675 ^@ http://purl.uniprot.org/uniprot/C9RGW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS05795 ^@ http://purl.uniprot.org/uniprot/C9RHI8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.|||Homodimer.|||Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. http://togogenome.org/gene/579137:METVU_RS00925 ^@ http://purl.uniprot.org/uniprot/C9REQ2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. CofG family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.|||The FO synthase complex consists of two subunits, CofG and CofH. http://togogenome.org/gene/579137:METVU_RS04685 ^@ http://purl.uniprot.org/uniprot/C9RGW6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/579137:METVU_RS04480 ^@ http://purl.uniprot.org/uniprot/C9RGS3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyltransferase superfamily. TrmY family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs. http://togogenome.org/gene/579137:METVU_RS03695 ^@ http://purl.uniprot.org/uniprot/C9RGA8 ^@ Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. http://togogenome.org/gene/579137:METVU_RS07590 ^@ http://purl.uniprot.org/uniprot/C9RDL7 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase Pus10 family.|||Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/579137:METVU_RS06310 ^@ http://purl.uniprot.org/uniprot/C9RHT9 ^@ Similarity ^@ Belongs to the archaeal ATPase family. http://togogenome.org/gene/579137:METVU_RS06960 ^@ http://purl.uniprot.org/uniprot/C9RI71 ^@ Similarity ^@ Belongs to the HMD family. http://togogenome.org/gene/579137:METVU_RS04775 ^@ http://purl.uniprot.org/uniprot/C9RGY4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.|||Cytoplasm|||Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. http://togogenome.org/gene/579137:METVU_RS02145 ^@ http://purl.uniprot.org/uniprot/C9RFE2 ^@ Function|||Similarity ^@ Belongs to the rubredoxin family.|||Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule. http://togogenome.org/gene/579137:METVU_RS03690 ^@ http://purl.uniprot.org/uniprot/C9RGA7 ^@ Function|||Similarity ^@ Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.|||Belongs to the archease family. http://togogenome.org/gene/579137:METVU_RS03025 ^@ http://purl.uniprot.org/uniprot/C9RFX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/579137:METVU_RS00295 ^@ http://purl.uniprot.org/uniprot/C9REC9 ^@ Similarity ^@ Belongs to the sulfate adenylyltransferase family. http://togogenome.org/gene/579137:METVU_RS05235 ^@ http://purl.uniprot.org/uniprot/C9RH78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.|||Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/579137:METVU_RS01375 ^@ http://purl.uniprot.org/uniprot/C9REZ3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.|||Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.|||Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/579137:METVU_RS07955 ^@ http://purl.uniprot.org/uniprot/C9RDT1 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. http://togogenome.org/gene/579137:METVU_RS03810 ^@ http://purl.uniprot.org/uniprot/C9RGD5 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/579137:METVU_RS06890 ^@ http://purl.uniprot.org/uniprot/C9RI57 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapB family.|||Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. http://togogenome.org/gene/579137:METVU_RS03800 ^@ http://purl.uniprot.org/uniprot/C9RGD3 ^@ Similarity ^@ Belongs to the peptidase C56 family. http://togogenome.org/gene/579137:METVU_RS05430 ^@ http://purl.uniprot.org/uniprot/C9RHB7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS06995 ^@ http://purl.uniprot.org/uniprot/C9RI78 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/579137:METVU_RS05890 ^@ http://purl.uniprot.org/uniprot/C9RHK7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobD/CbiB family.|||Cell membrane|||Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/579137:METVU_RS05650 ^@ http://purl.uniprot.org/uniprot/C9RHG1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.|||Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).|||Homotetramer. Interacts with SepCysS. http://togogenome.org/gene/579137:METVU_RS04755 ^@ http://purl.uniprot.org/uniprot/C9RGY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Cell membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.|||Membrane http://togogenome.org/gene/579137:METVU_RS05485 ^@ http://purl.uniprot.org/uniprot/C9RHC8 ^@ Similarity ^@ Belongs to the UPF0251 family. http://togogenome.org/gene/579137:METVU_RS08130 ^@ http://purl.uniprot.org/uniprot/C9RDW3 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/579137:METVU_RS03620 ^@ http://purl.uniprot.org/uniprot/C9RG93 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.|||Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.|||Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers. http://togogenome.org/gene/579137:METVU_RS07580 ^@ http://purl.uniprot.org/uniprot/C9RDL5 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS04030 ^@ http://purl.uniprot.org/uniprot/C9RGI0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/579137:METVU_RS04320 ^@ http://purl.uniprot.org/uniprot/C9RGP0 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the NifH/BchL/ChlL family.|||Binds 1 [4Fe-4S] cluster per dimer.|||Homodimer.|||The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.|||The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.|||The reversible ADP-ribosylation of Arg-97 inactivates the nitrogenase reductase and regulates nitrogenase activity. http://togogenome.org/gene/579137:METVU_RS06830 ^@ http://purl.uniprot.org/uniprot/C9RI45 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/579137:METVU_RS04890 ^@ http://purl.uniprot.org/uniprot/C9RH07 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/579137:METVU_RS04115 ^@ http://purl.uniprot.org/uniprot/C9RGJ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/579137:METVU_RS06610 ^@ http://purl.uniprot.org/uniprot/C9RHZ6 ^@ Similarity|||Subunit ^@ Belongs to the CarB family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/579137:METVU_RS07875 ^@ http://purl.uniprot.org/uniprot/C9RDR4 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/579137:METVU_RS05720 ^@ http://purl.uniprot.org/uniprot/C9RHH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-archaeol synthase family.|||Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.|||Cell membrane http://togogenome.org/gene/579137:METVU_RS07775 ^@ http://purl.uniprot.org/uniprot/C9RDP3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/579137:METVU_RS03680 ^@ http://purl.uniprot.org/uniprot/C9RGA5 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethane group. http://togogenome.org/gene/579137:METVU_RS00015 ^@ http://purl.uniprot.org/uniprot/C9RE74 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/579137:METVU_RS02690 ^@ http://purl.uniprot.org/uniprot/C9RFQ3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/579137:METVU_RS08330 ^@ http://purl.uniprot.org/uniprot/C9RE03 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS01480 ^@ http://purl.uniprot.org/uniprot/C9RF15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Mediates influx of magnesium ions.|||Membrane http://togogenome.org/gene/579137:METVU_RS06925 ^@ http://purl.uniprot.org/uniprot/C9RI64 ^@ Similarity ^@ Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/579137:METVU_RS07595 ^@ http://purl.uniprot.org/uniprot/C9RDL8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/579137:METVU_RS01210 ^@ http://purl.uniprot.org/uniprot/C9REV9 ^@ Similarity ^@ Belongs to the UPF0166 family. http://togogenome.org/gene/579137:METVU_RS05340 ^@ http://purl.uniprot.org/uniprot/C9RH99 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family. http://togogenome.org/gene/579137:METVU_RS03155 ^@ http://purl.uniprot.org/uniprot/C9RG03 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA. http://togogenome.org/gene/579137:METVU_RS08285 ^@ http://purl.uniprot.org/uniprot/C9RDZ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29. http://togogenome.org/gene/579137:METVU_RS01120 ^@ http://purl.uniprot.org/uniprot/C9REU1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/579137:METVU_RS01305 ^@ http://purl.uniprot.org/uniprot/C9REX8 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/579137:METVU_RS08510 ^@ http://purl.uniprot.org/uniprot/C9RE37 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGMT family.|||Cytoplasm|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.|||This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles. http://togogenome.org/gene/579137:METVU_RS05655 ^@ http://purl.uniprot.org/uniprot/C9RHG2 ^@ Similarity ^@ Belongs to the UPF0237 family. http://togogenome.org/gene/579137:METVU_RS01560 ^@ http://purl.uniprot.org/uniprot/C9RF33 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS07975 ^@ http://purl.uniprot.org/uniprot/C9RDT5 ^@ Function|||Similarity ^@ Belongs to the V-ATPase E subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/579137:METVU_RS06055 ^@ http://purl.uniprot.org/uniprot/C9RHN9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS01860 ^@ http://purl.uniprot.org/uniprot/C9RF89 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/579137:METVU_RS01180 ^@ http://purl.uniprot.org/uniprot/C9REV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal histone HMF family.|||Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).|||Chromosome|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS06760 ^@ http://purl.uniprot.org/uniprot/C9RI27 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/579137:METVU_RS04695 ^@ http://purl.uniprot.org/uniprot/C9RGW8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6B family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/579137:METVU_RS08715 ^@ http://purl.uniprot.org/uniprot/C9RE69 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS07515 ^@ http://purl.uniprot.org/uniprot/C9RDK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS05255 ^@ http://purl.uniprot.org/uniprot/C9RH82 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.|||Homodimer. http://togogenome.org/gene/579137:METVU_RS03145 ^@ http://purl.uniprot.org/uniprot/C9RG01 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA polymerase delta/II small subunit family.|||Heterodimer of a large subunit and a small subunit.|||Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. http://togogenome.org/gene/579137:METVU_RS02120 ^@ http://purl.uniprot.org/uniprot/C9RFD7 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/579137:METVU_RS08710 ^@ http://purl.uniprot.org/uniprot/C9RE68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal histone HMF family.|||Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).|||Chromosome|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS04815 ^@ http://purl.uniprot.org/uniprot/C9RGZ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS05845 ^@ http://purl.uniprot.org/uniprot/C9RHJ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyl-coenzyme M reductase beta subunit family.|||Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.|||Hexamer of two alpha, two beta, and two gamma chains.|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers. http://togogenome.org/gene/579137:METVU_RS07520 ^@ http://purl.uniprot.org/uniprot/C9RDK3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/579137:METVU_RS02000 ^@ http://purl.uniprot.org/uniprot/C9RFB4 ^@ Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 2 family. http://togogenome.org/gene/579137:METVU_RS00450 ^@ http://purl.uniprot.org/uniprot/C9REG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Archaeal flagellum|||Belongs to the archaeal flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella. http://togogenome.org/gene/579137:METVU_RS08560 ^@ http://purl.uniprot.org/uniprot/C9RE46 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/579137:METVU_RS04075 ^@ http://purl.uniprot.org/uniprot/C9RGI9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/579137:METVU_RS05610 ^@ http://purl.uniprot.org/uniprot/C9RHF3 ^@ Similarity ^@ Belongs to the CRISPR-associated Cas10/Csm1 family. http://togogenome.org/gene/579137:METVU_RS08260 ^@ http://purl.uniprot.org/uniprot/C9RDY9 ^@ Function|||Similarity ^@ Belongs to the Tfx family.|||Putative transcriptional regulator. http://togogenome.org/gene/579137:METVU_RS03045 ^@ http://purl.uniprot.org/uniprot/C9RFY1 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/579137:METVU_RS03585 ^@ http://purl.uniprot.org/uniprot/C9RG86 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS06910 ^@ http://purl.uniprot.org/uniprot/C9RI61 ^@ Similarity ^@ Belongs to the UDPGP type 2 family. http://togogenome.org/gene/579137:METVU_RS00305 ^@ http://purl.uniprot.org/uniprot/C9RED1 ^@ Function|||Similarity ^@ Belongs to the APS kinase family.|||Catalyzes the synthesis of activated sulfate. http://togogenome.org/gene/579137:METVU_RS02955 ^@ http://purl.uniprot.org/uniprot/C9RFW2 ^@ Function|||Similarity ^@ Acts on leucine, isoleucine and valine.|||Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/579137:METVU_RS05935 ^@ http://purl.uniprot.org/uniprot/C9RHL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.|||Belongs to the peptidase S16 family. Archaeal LonB subfamily.|||Cell membrane|||Homohexamer. Organized in a ring with a central cavity.|||Membrane http://togogenome.org/gene/579137:METVU_RS07750 ^@ http://purl.uniprot.org/uniprot/C9RDN8 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/579137:METVU_RS03575 ^@ http://purl.uniprot.org/uniprot/C9RG84 ^@ Similarity ^@ Belongs to the UPF0285 family. http://togogenome.org/gene/579137:METVU_RS07615 ^@ http://purl.uniprot.org/uniprot/C9RDM2 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/579137:METVU_RS06045 ^@ http://purl.uniprot.org/uniprot/C9RHN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal NMN adenylyltransferase family.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS03665 ^@ http://purl.uniprot.org/uniprot/C9RGA2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS07525 ^@ http://purl.uniprot.org/uniprot/C9RDK4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Part of the 30S ribosomal subunit.|||With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. http://togogenome.org/gene/579137:METVU_RS02580 ^@ http://purl.uniprot.org/uniprot/C9RFN0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin alpha subunit family.|||Belongs to the prefoldin subunit alpha family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/579137:METVU_RS07535 ^@ http://purl.uniprot.org/uniprot/C9RDK6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/579137:METVU_RS01385 ^@ http://purl.uniprot.org/uniprot/C9REZ5 ^@ Function|||Similarity ^@ Belongs to the HdrB family.|||Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). http://togogenome.org/gene/579137:METVU_RS00565 ^@ http://purl.uniprot.org/uniprot/C9REI2 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS01075 ^@ http://purl.uniprot.org/uniprot/C9RET2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/579137:METVU_RS02075 ^@ http://purl.uniprot.org/uniprot/C9RFC8 ^@ Similarity ^@ Belongs to the UPF0200 family. http://togogenome.org/gene/579137:METVU_RS02605 ^@ http://purl.uniprot.org/uniprot/C9RFN5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CbiX family. CbiXS subfamily.|||Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.|||Homotetramer; dimer of dimers. http://togogenome.org/gene/579137:METVU_RS00390 ^@ http://purl.uniprot.org/uniprot/C9REE8 ^@ Function|||Similarity ^@ Belongs to the deoxyhypusine synthase family.|||Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. http://togogenome.org/gene/579137:METVU_RS07045 ^@ http://purl.uniprot.org/uniprot/C9RI88 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.|||Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.|||Homodecamer. http://togogenome.org/gene/579137:METVU_RS08295 ^@ http://purl.uniprot.org/uniprot/C9RDZ6 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/579137:METVU_RS04510 ^@ http://purl.uniprot.org/uniprot/C9RGS9 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/579137:METVU_RS05195 ^@ http://purl.uniprot.org/uniprot/C9RH69 ^@ Function|||Similarity ^@ Belongs to the glutaredoxin family.|||Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro. http://togogenome.org/gene/579137:METVU_RS08110 ^@ http://purl.uniprot.org/uniprot/C9RDW0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/579137:METVU_RS04190 ^@ http://purl.uniprot.org/uniprot/C9RGL2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrI family.|||Binds 1 zinc ion per subunit.|||Contains catalytic and regulatory chains.|||Involved in allosteric regulation of aspartate carbamoyltransferase. http://togogenome.org/gene/579137:METVU_RS01490 ^@ http://purl.uniprot.org/uniprot/C9RF17 ^@ Function|||Similarity ^@ Belongs to the MTD family.|||Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. http://togogenome.org/gene/579137:METVU_RS02035 ^@ http://purl.uniprot.org/uniprot/C9RFC0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS00775 ^@ http://purl.uniprot.org/uniprot/C9REM3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MtrH family.|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/579137:METVU_RS05855 ^@ http://purl.uniprot.org/uniprot/C9RHK0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the methyl-coenzyme M reductase alpha subunit family.|||Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.|||Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.|||Hexamer of two alpha, two beta, and two gamma chains.|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers. http://togogenome.org/gene/579137:METVU_RS00790 ^@ http://purl.uniprot.org/uniprot/C9REM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mer family.|||Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS07780 ^@ http://purl.uniprot.org/uniprot/C9RDP4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/579137:METVU_RS04080 ^@ http://purl.uniprot.org/uniprot/C9RGJ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.|||Membrane http://togogenome.org/gene/579137:METVU_RS05765 ^@ http://purl.uniprot.org/uniprot/C9RHI2 ^@ Caution|||Function|||Similarity ^@ Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.|||Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.|||In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.|||In the N-terminal section; belongs to the formaldehyde-activating enzyme family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS02335 ^@ http://purl.uniprot.org/uniprot/C9RFI1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EhaA family.|||Cell membrane|||Membrane|||One of the integral membrane subunits of multisubunit membrane-bound [NiFe]-hydrogenase eha. Eha is predicted to form large electron transfer complex and might catalyze energy-driven reduction of low-potential redox carriers.|||Putative multisubunit membrane-bound [NiFe]-hydrogenase eha is composed of at least 20 subunits. http://togogenome.org/gene/579137:METVU_RS02380 ^@ http://purl.uniprot.org/uniprot/C9RFJ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS02950 ^@ http://purl.uniprot.org/uniprot/C9RFW1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/579137:METVU_RS05360 ^@ http://purl.uniprot.org/uniprot/C9RHA3 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/579137:METVU_RS02740 ^@ http://purl.uniprot.org/uniprot/C9RFR5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/579137:METVU_RS03005 ^@ http://purl.uniprot.org/uniprot/C9RFX3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS00640 ^@ http://purl.uniprot.org/uniprot/C9REJ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS01890 ^@ http://purl.uniprot.org/uniprot/C9RF94 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal FAD synthase family.|||Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.|||Homodimer. http://togogenome.org/gene/579137:METVU_RS03875 ^@ http://purl.uniprot.org/uniprot/C9RGE8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dCTP deaminase family.|||Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.|||Homotrimer. http://togogenome.org/gene/579137:METVU_RS03290 ^@ http://purl.uniprot.org/uniprot/C9RG28 ^@ Similarity ^@ Belongs to the UPF0179 family. http://togogenome.org/gene/579137:METVU_RS07895 ^@ http://purl.uniprot.org/uniprot/C9RDR8 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/579137:METVU_RS00750 ^@ http://purl.uniprot.org/uniprot/C9REL8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrC family.|||Cell membrane|||Membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/579137:METVU_RS04100 ^@ http://purl.uniprot.org/uniprot/C9RGJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/579137:METVU_RS01105 ^@ http://purl.uniprot.org/uniprot/C9RET8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/579137:METVU_RS04680 ^@ http://purl.uniprot.org/uniprot/C9RGW5 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/579137:METVU_RS07980 ^@ http://purl.uniprot.org/uniprot/C9RDT6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase proteolipid subunit family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/579137:METVU_RS07725 ^@ http://purl.uniprot.org/uniprot/C9RDN3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit.|||Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. http://togogenome.org/gene/579137:METVU_RS08415 ^@ http://purl.uniprot.org/uniprot/C9RE18 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. http://togogenome.org/gene/579137:METVU_RS01125 ^@ http://purl.uniprot.org/uniprot/C9REU2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/579137:METVU_RS06490 ^@ http://purl.uniprot.org/uniprot/C9RHX5 ^@ Function ^@ Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/579137:METVU_RS03410 ^@ http://purl.uniprot.org/uniprot/C9RG51 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the GatB/GatE family. GatE subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/579137:METVU_RS07280 ^@ http://purl.uniprot.org/uniprot/C9RID3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/579137:METVU_RS04120 ^@ http://purl.uniprot.org/uniprot/C9RGJ8 ^@ Function|||Similarity ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. http://togogenome.org/gene/579137:METVU_RS07145 ^@ http://purl.uniprot.org/uniprot/C9RIA7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/579137:METVU_RS01100 ^@ http://purl.uniprot.org/uniprot/C9RET7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/579137:METVU_RS04050 ^@ http://purl.uniprot.org/uniprot/C9RGI4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the quinolinate synthase family. Type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS02495 ^@ http://purl.uniprot.org/uniprot/C9RFL3 ^@ Similarity ^@ Belongs to the UPF0252 family. http://togogenome.org/gene/579137:METVU_RS05995 ^@ http://purl.uniprot.org/uniprot/C9RHM7 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated Csm2 family.|||This subunit may be involved in monitoring complementarity of crRNA and target RNA. http://togogenome.org/gene/579137:METVU_RS02015 ^@ http://purl.uniprot.org/uniprot/C9RFB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily.|||Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS04455 ^@ http://purl.uniprot.org/uniprot/C9RGR8 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/579137:METVU_RS07825 ^@ http://purl.uniprot.org/uniprot/C9RDQ4 ^@ Function|||Similarity ^@ Belongs to the TBP family.|||General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. http://togogenome.org/gene/579137:METVU_RS07030 ^@ http://purl.uniprot.org/uniprot/C9RI85 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/579137:METVU_RS06495 ^@ http://purl.uniprot.org/uniprot/C9RHX6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dethiobiotin synthetase family.|||Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS08105 ^@ http://purl.uniprot.org/uniprot/C9RDV9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/579137:METVU_RS05200 ^@ http://purl.uniprot.org/uniprot/C9RH71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/579137:METVU_RS05225 ^@ http://purl.uniprot.org/uniprot/C9RH76 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/579137:METVU_RS00285 ^@ http://purl.uniprot.org/uniprot/C9REC7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS02405 ^@ http://purl.uniprot.org/uniprot/C9RFJ5 ^@ Similarity ^@ Belongs to the complex I 49 kDa subunit family. http://togogenome.org/gene/579137:METVU_RS01090 ^@ http://purl.uniprot.org/uniprot/C9RET5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||Located at the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/579137:METVU_RS07570 ^@ http://purl.uniprot.org/uniprot/C9RDL3 ^@ Similarity ^@ Belongs to the HisA/HisF family. http://togogenome.org/gene/579137:METVU_RS02450 ^@ http://purl.uniprot.org/uniprot/C9RFK4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FTR family.|||Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/579137:METVU_RS07245 ^@ http://purl.uniprot.org/uniprot/C9RIC5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/579137:METVU_RS07260 ^@ http://purl.uniprot.org/uniprot/C9RIC9 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.|||Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. http://togogenome.org/gene/579137:METVU_RS05885 ^@ http://purl.uniprot.org/uniprot/C9RHK6 ^@ Function ^@ Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA. http://togogenome.org/gene/579137:METVU_RS03285 ^@ http://purl.uniprot.org/uniprot/C9RG27 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/579137:METVU_RS00760 ^@ http://purl.uniprot.org/uniprot/C9REM0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrA family.|||Binds 1 5-hydroxybenzimidazolylcobamide group.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/579137:METVU_RS06855 ^@ http://purl.uniprot.org/uniprot/C9RI50 ^@ Similarity ^@ Belongs to the UPF0210 family. http://togogenome.org/gene/579137:METVU_RS08095 ^@ http://purl.uniprot.org/uniprot/C9RDV7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL18 family. http://togogenome.org/gene/579137:METVU_RS07075 ^@ http://purl.uniprot.org/uniprot/C9RI93 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily. http://togogenome.org/gene/579137:METVU_RS07190 ^@ http://purl.uniprot.org/uniprot/C9RIB6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).|||Belongs to the TDD superfamily. TSR3 family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS07380 ^@ http://purl.uniprot.org/uniprot/C9RIF2 ^@ Function|||Similarity ^@ Belongs to the HARP family.|||RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. http://togogenome.org/gene/579137:METVU_RS06500 ^@ http://purl.uniprot.org/uniprot/C9RHX7 ^@ Caution|||Function|||Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS05630 ^@ http://purl.uniprot.org/uniprot/C9RHF7 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated Csm5 family.|||This subunit might be involved in maturation of a crRNA intermediate to its mature form. http://togogenome.org/gene/579137:METVU_RS01495 ^@ http://purl.uniprot.org/uniprot/C9RF18 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS00605 ^@ http://purl.uniprot.org/uniprot/C9REJ0 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/579137:METVU_RS02115 ^@ http://purl.uniprot.org/uniprot/C9RFD6 ^@ Activity Regulation|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer. http://togogenome.org/gene/579137:METVU_RS06570 ^@ http://purl.uniprot.org/uniprot/C9RHZ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Cytoplasm|||Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.|||Part of the 50S ribosomal subunit. Probably part of the RNase P complex. http://togogenome.org/gene/579137:METVU_RS06205 ^@ http://purl.uniprot.org/uniprot/C9RHR8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).|||Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS08645 ^@ http://purl.uniprot.org/uniprot/C9RE62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0014 family.|||Membrane http://togogenome.org/gene/579137:METVU_RS06290 ^@ http://purl.uniprot.org/uniprot/C9RHT5 ^@ Similarity ^@ Belongs to the FrhG family. http://togogenome.org/gene/579137:METVU_RS03430 ^@ http://purl.uniprot.org/uniprot/C9RG55 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family. RadB subfamily.|||Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. http://togogenome.org/gene/579137:METVU_RS05915 ^@ http://purl.uniprot.org/uniprot/C9RHL2 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/579137:METVU_RS07255 ^@ http://purl.uniprot.org/uniprot/C9RIC7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Membrane http://togogenome.org/gene/579137:METVU_RS05345 ^@ http://purl.uniprot.org/uniprot/C9RHA0 ^@ Function|||Similarity ^@ Belongs to the eIF-6 family.|||Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. http://togogenome.org/gene/579137:METVU_RS00820 ^@ http://purl.uniprot.org/uniprot/C9REN1 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/579137:METVU_RS07890 ^@ http://purl.uniprot.org/uniprot/C9RDR7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/579137:METVU_RS04225 ^@ http://purl.uniprot.org/uniprot/C9RGL9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS07440 ^@ http://purl.uniprot.org/uniprot/C9RDI7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS01880 ^@ http://purl.uniprot.org/uniprot/C9RF92 ^@ Similarity ^@ Belongs to the HypD family. http://togogenome.org/gene/579137:METVU_RS04925 ^@ http://purl.uniprot.org/uniprot/C9RH14 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/579137:METVU_RS05415 ^@ http://purl.uniprot.org/uniprot/C9RHB4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS00885 ^@ http://purl.uniprot.org/uniprot/C9REP4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/579137:METVU_RS02185 ^@ http://purl.uniprot.org/uniprot/C9RFE9 ^@ Function|||Similarity ^@ Belongs to the HdrB family.|||Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). http://togogenome.org/gene/579137:METVU_RS00740 ^@ http://purl.uniprot.org/uniprot/C9REL6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrE family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/579137:METVU_RS08530 ^@ http://purl.uniprot.org/uniprot/C9RE40 ^@ Similarity ^@ Belongs to the HMD family. http://togogenome.org/gene/579137:METVU_RS08325 ^@ http://purl.uniprot.org/uniprot/C9RE02 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/579137:METVU_RS08300 ^@ http://purl.uniprot.org/uniprot/C9RDZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.|||Membrane http://togogenome.org/gene/579137:METVU_RS00830 ^@ http://purl.uniprot.org/uniprot/C9REN3 ^@ Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. http://togogenome.org/gene/579137:METVU_RS08280 ^@ http://purl.uniprot.org/uniprot/C9RDZ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/579137:METVU_RS01845 ^@ http://purl.uniprot.org/uniprot/C9RF86 ^@ Similarity ^@ Belongs to the ComB family. http://togogenome.org/gene/579137:METVU_RS04380 ^@ http://purl.uniprot.org/uniprot/C9RGQ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/579137:METVU_RS00870 ^@ http://purl.uniprot.org/uniprot/C9REP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aTrm56 family.|||Cytoplasm|||Homodimer.|||Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs. http://togogenome.org/gene/579137:METVU_RS01185 ^@ http://purl.uniprot.org/uniprot/C9REV4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/579137:METVU_RS03600 ^@ http://purl.uniprot.org/uniprot/C9RG89 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS06190 ^@ http://purl.uniprot.org/uniprot/C9RHR5 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/579137:METVU_RS00185 ^@ http://purl.uniprot.org/uniprot/C9REA7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase IV family.|||Binds 1 Fe(2+) ion per subunit.|||Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.|||Homodimer. http://togogenome.org/gene/579137:METVU_RS07195 ^@ http://purl.uniprot.org/uniprot/C9RIB7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL40 family. http://togogenome.org/gene/579137:METVU_RS04970 ^@ http://purl.uniprot.org/uniprot/C9RH23 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/579137:METVU_RS05145 ^@ http://purl.uniprot.org/uniprot/C9RH59 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 [4Fe-4S] cluster.|||Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).|||Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). http://togogenome.org/gene/579137:METVU_RS01470 ^@ http://purl.uniprot.org/uniprot/C9RF13 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS03545 ^@ http://purl.uniprot.org/uniprot/C9RG78 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/579137:METVU_RS07835 ^@ http://purl.uniprot.org/uniprot/C9RDQ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/579137:METVU_RS00445 ^@ http://purl.uniprot.org/uniprot/C9REF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Archaeal flagellum|||Belongs to the archaeal flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella. http://togogenome.org/gene/579137:METVU_RS01170 ^@ http://purl.uniprot.org/uniprot/C9REV1 ^@ Similarity ^@ Belongs to the UPF0284 family. http://togogenome.org/gene/579137:METVU_RS08315 ^@ http://purl.uniprot.org/uniprot/C9RE00 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PurS family.|||Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/579137:METVU_RS07935 ^@ http://purl.uniprot.org/uniprot/C9RDS7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.|||Belongs to the histone-like Alba family.|||Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.|||Chromosome|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/579137:METVU_RS08585 ^@ http://purl.uniprot.org/uniprot/C9RE51 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS00985 ^@ http://purl.uniprot.org/uniprot/C9RER4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0104 family.|||Membrane http://togogenome.org/gene/579137:METVU_RS06435 ^@ http://purl.uniprot.org/uniprot/C9RHW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS05440 ^@ http://purl.uniprot.org/uniprot/C9RHB9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PPase class C family.|||Binds 2 manganese ions per subunit.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS05730 ^@ http://purl.uniprot.org/uniprot/C9RHH6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/579137:METVU_RS05330 ^@ http://purl.uniprot.org/uniprot/C9RH97 ^@ Function|||Similarity ^@ Belongs to the group II decarboxylase family. MfnA subfamily.|||Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis. http://togogenome.org/gene/579137:METVU_RS04540 ^@ http://purl.uniprot.org/uniprot/C9RGT5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the diaminopimelate epimerase family.|||Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS02070 ^@ http://purl.uniprot.org/uniprot/C9RFC7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS05295 ^@ http://purl.uniprot.org/uniprot/C9RH90 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NifD/NifK/NifE/NifN family.|||Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).|||This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation. http://togogenome.org/gene/579137:METVU_RS02435 ^@ http://purl.uniprot.org/uniprot/C9RFK1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the archaeal riboflavin kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN). http://togogenome.org/gene/579137:METVU_RS03730 ^@ http://purl.uniprot.org/uniprot/C9RGB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/579137:METVU_RS04705 ^@ http://purl.uniprot.org/uniprot/C9RGX0 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. http://togogenome.org/gene/579137:METVU_RS03850 ^@ http://purl.uniprot.org/uniprot/C9RGE3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the creatininase superfamily. FAPy deformylase family.|||Catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy).|||Homodimer.|||Requires an additional second metal ion that could be Fe(2+) or Zn(2+).|||Requires one Fe(2+) ion for activity. http://togogenome.org/gene/579137:METVU_RS04350 ^@ http://purl.uniprot.org/uniprot/C9RGP6 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/579137:METVU_RS03675 ^@ http://purl.uniprot.org/uniprot/C9RGA4 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/579137:METVU_RS01715 ^@ http://purl.uniprot.org/uniprot/C9RF60 ^@ Similarity ^@ Belongs to the UPF0146 family. http://togogenome.org/gene/579137:METVU_RS06935 ^@ http://purl.uniprot.org/uniprot/C9RI66 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS05770 ^@ http://purl.uniprot.org/uniprot/C9RHI3 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily. http://togogenome.org/gene/579137:METVU_RS03100 ^@ http://purl.uniprot.org/uniprot/C9RFZ2 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. http://togogenome.org/gene/579137:METVU_RS07205 ^@ http://purl.uniprot.org/uniprot/C9RIB9 ^@ Similarity ^@ Belongs to the HMG-CoA reductase family. http://togogenome.org/gene/579137:METVU_RS07880 ^@ http://purl.uniprot.org/uniprot/C9RDR5 ^@ Function ^@ Probably involved in the biogenesis of the ribosome. http://togogenome.org/gene/579137:METVU_RS08245 ^@ http://purl.uniprot.org/uniprot/C9RDY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/579137:METVU_RS00765 ^@ http://purl.uniprot.org/uniprot/C9REM1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrF family.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/579137:METVU_RS04670 ^@ http://purl.uniprot.org/uniprot/C9RGW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0104 family.|||Membrane http://togogenome.org/gene/579137:METVU_RS06000 ^@ http://purl.uniprot.org/uniprot/C9RHM8 ^@ Similarity ^@ Belongs to the CRISPR-associated Csm3 family. http://togogenome.org/gene/579137:METVU_RS01130 ^@ http://purl.uniprot.org/uniprot/C9REU3 ^@ Function|||Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family.|||Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. http://togogenome.org/gene/579137:METVU_RS00520 ^@ http://purl.uniprot.org/uniprot/C9REH4 ^@ Similarity ^@ Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. http://togogenome.org/gene/579137:METVU_RS02260 ^@ http://purl.uniprot.org/uniprot/C9RFG4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS05800 ^@ http://purl.uniprot.org/uniprot/C9RHI9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS01640 ^@ http://purl.uniprot.org/uniprot/C9RF49 ^@ Similarity ^@ Belongs to the archaeal ATPase family. http://togogenome.org/gene/579137:METVU_RS07285 ^@ http://purl.uniprot.org/uniprot/C9RID4 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. http://togogenome.org/gene/579137:METVU_RS05740 ^@ http://purl.uniprot.org/uniprot/C9RHH8 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/579137:METVU_RS03700 ^@ http://purl.uniprot.org/uniprot/C9RGA9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS07915 ^@ http://purl.uniprot.org/uniprot/C9RDS2 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the archaeal phosphopantothenate synthetase family.|||Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS05970 ^@ http://purl.uniprot.org/uniprot/C9RHM2 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/579137:METVU_RS05290 ^@ http://purl.uniprot.org/uniprot/C9RH89 ^@ Similarity ^@ Belongs to the P(II) protein family. http://togogenome.org/gene/579137:METVU_RS08085 ^@ http://purl.uniprot.org/uniprot/C9RDV5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/579137:METVU_RS01950 ^@ http://purl.uniprot.org/uniprot/C9RFA5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/579137:METVU_RS05245 ^@ http://purl.uniprot.org/uniprot/C9RH80 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.|||Cell membrane|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/579137:METVU_RS03360 ^@ http://purl.uniprot.org/uniprot/C9RG41 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/579137:METVU_RS01050 ^@ http://purl.uniprot.org/uniprot/C9RES7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/579137:METVU_RS02150 ^@ http://purl.uniprot.org/uniprot/C9RFE3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/579137:METVU_RS08310 ^@ http://purl.uniprot.org/uniprot/C9RDZ9 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/579137:METVU_RS00825 ^@ http://purl.uniprot.org/uniprot/C9REN2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose 5-phosphate isomerase family.|||Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.|||Homodimer. http://togogenome.org/gene/579137:METVU_RS01320 ^@ http://purl.uniprot.org/uniprot/C9REY2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. Biotin synthase family.|||Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.|||Homodimer. http://togogenome.org/gene/579137:METVU_RS01025 ^@ http://purl.uniprot.org/uniprot/C9RES2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal adenylate kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/579137:METVU_RS00620 ^@ http://purl.uniprot.org/uniprot/C9REJ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm|||Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.|||Heterodimer of two subunits, one of which binds GTP. http://togogenome.org/gene/579137:METVU_RS06710 ^@ http://purl.uniprot.org/uniprot/C9RI17 ^@ Similarity ^@ Belongs to the UPF0292 family. http://togogenome.org/gene/579137:METVU_RS03115 ^@ http://purl.uniprot.org/uniprot/C9RFZ5 ^@ Similarity|||Subunit ^@ Belongs to the L-cysteine desulfidase family.|||Homotrimer. http://togogenome.org/gene/579137:METVU_RS06770 ^@ http://purl.uniprot.org/uniprot/C9RI31 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS05495 ^@ http://purl.uniprot.org/uniprot/C9RHD0 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the SMC family. RAD50 subfamily.|||Binds 1 zinc ion per homodimer.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.|||The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer. http://togogenome.org/gene/579137:METVU_RS01750 ^@ http://purl.uniprot.org/uniprot/C9RF66 ^@ Similarity ^@ Belongs to the NOP5/NOP56 family. http://togogenome.org/gene/579137:METVU_RS03995 ^@ http://purl.uniprot.org/uniprot/C9RGH3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. http://togogenome.org/gene/579137:METVU_RS01915 ^@ http://purl.uniprot.org/uniprot/C9RF99 ^@ Similarity ^@ Belongs to the UPF0215 family. http://togogenome.org/gene/579137:METVU_RS01435 ^@ http://purl.uniprot.org/uniprot/C9RF06 ^@ Function|||Similarity ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.|||Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. http://togogenome.org/gene/579137:METVU_RS00530 ^@ http://purl.uniprot.org/uniprot/C9REH6 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the UPF0165 family. http://togogenome.org/gene/579137:METVU_RS07230 ^@ http://purl.uniprot.org/uniprot/C9RIC2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.|||Nucleus|||Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure. http://togogenome.org/gene/579137:METVU_RS07490 ^@ http://purl.uniprot.org/uniprot/C9RDJ7 ^@ Similarity ^@ Belongs to the organic radical-activating enzymes family. http://togogenome.org/gene/579137:METVU_RS07830 ^@ http://purl.uniprot.org/uniprot/C9RDQ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/579137:METVU_RS00610 ^@ http://purl.uniprot.org/uniprot/C9REJ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS00550 ^@ http://purl.uniprot.org/uniprot/C9REH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Membrane http://togogenome.org/gene/579137:METVU_RS04845 ^@ http://purl.uniprot.org/uniprot/C9RGZ8 ^@ Similarity ^@ Belongs to the archaeal ATPase family. http://togogenome.org/gene/579137:METVU_RS02565 ^@ http://purl.uniprot.org/uniprot/C9RFM7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/579137:METVU_RS05780 ^@ http://purl.uniprot.org/uniprot/C9RHI5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/579137:METVU_RS04935 ^@ http://purl.uniprot.org/uniprot/C9RH16 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/579137:METVU_RS03135 ^@ http://purl.uniprot.org/uniprot/C9RFZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/579137:METVU_RS00725 ^@ http://purl.uniprot.org/uniprot/C9REL3 ^@ Subunit ^@ MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known. http://togogenome.org/gene/579137:METVU_RS01985 ^@ http://purl.uniprot.org/uniprot/C9RFB1 ^@ Similarity ^@ Belongs to the HepT RNase toxin family. http://togogenome.org/gene/579137:METVU_RS07165 ^@ http://purl.uniprot.org/uniprot/C9RIB1 ^@ Function|||Similarity ^@ Belongs to the archaeal-type GTP cyclohydrolase family.|||Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity. http://togogenome.org/gene/579137:METVU_RS04940 ^@ http://purl.uniprot.org/uniprot/C9RH17 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS02175 ^@ http://purl.uniprot.org/uniprot/C9RFE7 ^@ Similarity ^@ Belongs to the desulfoferrodoxin family. http://togogenome.org/gene/579137:METVU_RS08505 ^@ http://purl.uniprot.org/uniprot/C9RE36 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homotetramer; dimer of dimers.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/579137:METVU_RS01795 ^@ http://purl.uniprot.org/uniprot/C9RF76 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. PoK subfamily.|||Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway. http://togogenome.org/gene/579137:METVU_RS07415 ^@ http://purl.uniprot.org/uniprot/C9RIF9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/579137:METVU_RS05380 ^@ http://purl.uniprot.org/uniprot/C9RHA7 ^@ Similarity ^@ Belongs to the SAM hydrolase / SAM-dependent halogenase family. http://togogenome.org/gene/579137:METVU_RS01820 ^@ http://purl.uniprot.org/uniprot/C9RF81 ^@ Similarity ^@ Belongs to the DeoC/FbaB aldolase family. http://togogenome.org/gene/579137:METVU_RS01675 ^@ http://purl.uniprot.org/uniprot/C9RF53 ^@ Similarity ^@ Belongs to the DNA2/NAM7 helicase family. http://togogenome.org/gene/579137:METVU_RS00280 ^@ http://purl.uniprot.org/uniprot/C9REC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gmhB family.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS03890 ^@ http://purl.uniprot.org/uniprot/C9RGF1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the YjjX NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/579137:METVU_RS06740 ^@ http://purl.uniprot.org/uniprot/C9RI23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/579137:METVU_RS01800 ^@ http://purl.uniprot.org/uniprot/C9RF77 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS01055 ^@ http://purl.uniprot.org/uniprot/C9RES8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/579137:METVU_RS06230 ^@ http://purl.uniprot.org/uniprot/C9RHS3 ^@ Function|||Similarity ^@ Belongs to the MfnB family.|||Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). http://togogenome.org/gene/579137:METVU_RS03965 ^@ http://purl.uniprot.org/uniprot/C9RGG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal histone HMF family.|||Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).|||Chromosome|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS08495 ^@ http://purl.uniprot.org/uniprot/C9RE34 ^@ Similarity ^@ Belongs to the UPF0280 family. http://togogenome.org/gene/579137:METVU_RS00690 ^@ http://purl.uniprot.org/uniprot/C9REK6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase small subunit family.|||Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/579137:METVU_RS01430 ^@ http://purl.uniprot.org/uniprot/C9RF05 ^@ Similarity ^@ Belongs to the UPF0173 family. http://togogenome.org/gene/579137:METVU_RS08595 ^@ http://purl.uniprot.org/uniprot/C9RE53 ^@ Function|||Similarity ^@ Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). http://togogenome.org/gene/579137:METVU_RS07920 ^@ http://purl.uniprot.org/uniprot/C9RDS3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/579137:METVU_RS00935 ^@ http://purl.uniprot.org/uniprot/C9REQ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic CoaD family.|||Cytoplasm|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/579137:METVU_RS01285 ^@ http://purl.uniprot.org/uniprot/C9REX4 ^@ Function|||Similarity ^@ Belongs to the CheD family.|||Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis. http://togogenome.org/gene/579137:METVU_RS07435 ^@ http://purl.uniprot.org/uniprot/C9RIG3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS03755 ^@ http://purl.uniprot.org/uniprot/C9RGC0 ^@ Subunit ^@ Homotetramer. http://togogenome.org/gene/579137:METVU_RS04445 ^@ http://purl.uniprot.org/uniprot/C9RGR6 ^@ Function|||Similarity ^@ Belongs to the archaeal-type DHQ synthase family.|||Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis. http://togogenome.org/gene/579137:METVU_RS04530 ^@ http://purl.uniprot.org/uniprot/C9RGT3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SPT5 family.|||Belongs to the archaeal Spt5 family.|||Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).|||Stimulates transcription elongation. http://togogenome.org/gene/579137:METVU_RS07885 ^@ http://purl.uniprot.org/uniprot/C9RDR6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/579137:METVU_RS04610 ^@ http://purl.uniprot.org/uniprot/C9RGV0 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/579137:METVU_RS06005 ^@ http://purl.uniprot.org/uniprot/C9RHM9 ^@ Similarity ^@ Belongs to the CRISPR-associated Csm4 family. http://togogenome.org/gene/579137:METVU_RS04635 ^@ http://purl.uniprot.org/uniprot/C9RGV6 ^@ Similarity ^@ Belongs to the ParA family. MinD subfamily. http://togogenome.org/gene/579137:METVU_RS03310 ^@ http://purl.uniprot.org/uniprot/C9RG32 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the branched-chain polyamine synthase family.|||Cytoplasm|||Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine. http://togogenome.org/gene/579137:METVU_RS03580 ^@ http://purl.uniprot.org/uniprot/C9RG85 ^@ Similarity ^@ Belongs to the MtxX family. http://togogenome.org/gene/579137:METVU_RS04505 ^@ http://purl.uniprot.org/uniprot/C9RGS8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS08100 ^@ http://purl.uniprot.org/uniprot/C9RDV8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the RNA polymerase complex. http://togogenome.org/gene/579137:METVU_RS08380 ^@ http://purl.uniprot.org/uniprot/C9RE12 ^@ Function|||Similarity ^@ Belongs to the archaeal IMP cyclohydrolase family.|||Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP. http://togogenome.org/gene/579137:METVU_RS06140 ^@ http://purl.uniprot.org/uniprot/C9RHQ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/579137:METVU_RS04090 ^@ http://purl.uniprot.org/uniprot/C9RGJ2 ^@ Similarity ^@ Belongs to the PstS family. http://togogenome.org/gene/579137:METVU_RS00380 ^@ http://purl.uniprot.org/uniprot/C9REE6 ^@ Function|||Miscellaneous|||Similarity ^@ Belongs to the L-aspartate dehydrogenase family.|||Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.|||The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia. http://togogenome.org/gene/579137:METVU_RS06690 ^@ http://purl.uniprot.org/uniprot/C9RI12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCH family.|||Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS05990 ^@ http://purl.uniprot.org/uniprot/C9RHM6 ^@ Similarity ^@ Belongs to the CRISPR-associated Cas10/Csm1 family. http://togogenome.org/gene/579137:METVU_RS08235 ^@ http://purl.uniprot.org/uniprot/C9RDY4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal histone HMF family.|||Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).|||Chromosome|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS02205 ^@ http://purl.uniprot.org/uniprot/C9RFF3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the hemerythrin family.|||Monomer.|||Oxygen-binding protein. May be involved in a storage mechanism or for delivery to oxygen-requiring enzymes. The oxygen-binding site contains two iron atoms. http://togogenome.org/gene/579137:METVU_RS06030 ^@ http://purl.uniprot.org/uniprot/C9RHN4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.|||Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers. http://togogenome.org/gene/579137:METVU_RS03105 ^@ http://purl.uniprot.org/uniprot/C9RFZ3 ^@ Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. http://togogenome.org/gene/579137:METVU_RS06875 ^@ http://purl.uniprot.org/uniprot/C9RI54 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/579137:METVU_RS00920 ^@ http://purl.uniprot.org/uniprot/C9REQ1 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. http://togogenome.org/gene/579137:METVU_RS05760 ^@ http://purl.uniprot.org/uniprot/C9RHI1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrK family.|||Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit.|||Heterotetramer of 2 PyrK and 2 PyrD type B subunits.|||Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). http://togogenome.org/gene/579137:METVU_RS08400 ^@ http://purl.uniprot.org/uniprot/C9RE15 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HCP family.|||Binds 1 [4Fe-4S] cluster.|||Binds 1 hybrid [4Fe-2O-2S] cluster.|||Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS05960 ^@ http://purl.uniprot.org/uniprot/C9RHM0 ^@ Similarity|||Subunit ^@ Belongs to the HTP reductase family.|||Homodimer. http://togogenome.org/gene/579137:METVU_RS04360 ^@ http://purl.uniprot.org/uniprot/C9RGP9 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/579137:METVU_RS06275 ^@ http://purl.uniprot.org/uniprot/C9RHT2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. BUD32 family.|||Binds 1 Fe(2+) ion per subunit.|||Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.|||Cytoplasm|||In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.|||In the N-terminal section; belongs to the KAE1 / TsaD family.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. http://togogenome.org/gene/579137:METVU_RS05590 ^@ http://purl.uniprot.org/uniprot/C9RHE9 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.|||Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS04200 ^@ http://purl.uniprot.org/uniprot/C9RGL4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.|||Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS02735 ^@ http://purl.uniprot.org/uniprot/C9RFR4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/579137:METVU_RS08575 ^@ http://purl.uniprot.org/uniprot/C9RE49 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/579137:METVU_RS04645 ^@ http://purl.uniprot.org/uniprot/C9RGV8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the transcriptional regulatory CopG/NikR family.|||Binds 1 nickel ion per subunit.|||Transcriptional regulator. http://togogenome.org/gene/579137:METVU_RS04605 ^@ http://purl.uniprot.org/uniprot/C9RGU9 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the FBP aldolase/phosphatase family.|||Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).|||Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.|||Homooctamer; dimer of tetramers. http://togogenome.org/gene/579137:METVU_RS05705 ^@ http://purl.uniprot.org/uniprot/C9RHH1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. Hel308 subfamily.|||DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.|||Monomer. http://togogenome.org/gene/579137:METVU_RS07950 ^@ http://purl.uniprot.org/uniprot/C9RDT0 ^@ Similarity ^@ Belongs to the archaeal ATPase family. http://togogenome.org/gene/579137:METVU_RS05420 ^@ http://purl.uniprot.org/uniprot/C9RHB5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Cell membrane|||Involved in protein export.|||Membrane|||Part of the protein translocation apparatus. Forms a complex with SecF. http://togogenome.org/gene/579137:METVU_RS08290 ^@ http://purl.uniprot.org/uniprot/C9RDZ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/579137:METVU_RS06985 ^@ http://purl.uniprot.org/uniprot/C9RI76 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/579137:METVU_RS02620 ^@ http://purl.uniprot.org/uniprot/C9RFN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/579137:METVU_RS04070 ^@ http://purl.uniprot.org/uniprot/C9RGI8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6A family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/579137:METVU_RS01095 ^@ http://purl.uniprot.org/uniprot/C9RET6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges. http://togogenome.org/gene/579137:METVU_RS08225 ^@ http://purl.uniprot.org/uniprot/C9RDY2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DtdA deacylase family.|||Binds 2 Zn(2+) ions per subunit.|||D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.|||Monomer. http://togogenome.org/gene/579137:METVU_RS05280 ^@ http://purl.uniprot.org/uniprot/C9RH87 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the NifH/BchL/ChlL family.|||Binds 1 [4Fe-4S] cluster per dimer.|||Homodimer.|||The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.|||The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.|||The reversible ADP-ribosylation of Arg-109 inactivates the nitrogenase reductase and regulates nitrogenase activity. http://togogenome.org/gene/579137:METVU_RS03970 ^@ http://purl.uniprot.org/uniprot/C9RGG8 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS00010 ^@ http://purl.uniprot.org/uniprot/C9RE73 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/579137:METVU_RS06575 ^@ http://purl.uniprot.org/uniprot/C9RHZ1 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP phosphoribosyltransferase family. Long subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Feedback inhibited by histidine. http://togogenome.org/gene/579137:METVU_RS07855 ^@ http://purl.uniprot.org/uniprot/C9RDR0 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/579137:METVU_RS00945 ^@ http://purl.uniprot.org/uniprot/C9REQ6 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the shikimate dehydrogenase family.|||Homodimer.|||Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS03845 ^@ http://purl.uniprot.org/uniprot/C9RGE2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the carbohydrate kinase PfkC family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS04245 ^@ http://purl.uniprot.org/uniprot/C9RGM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS06585 ^@ http://purl.uniprot.org/uniprot/C9RHZ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal DnaG primase family.|||Forms a ternary complex with MCM helicase and DNA.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/579137:METVU_RS00730 ^@ http://purl.uniprot.org/uniprot/C9REL4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyl-coenzyme M reductase gamma subunit family.|||Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.|||Hexamer of two alpha, two beta, and two gamma chains.|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers. http://togogenome.org/gene/579137:METVU_RS01040 ^@ http://purl.uniprot.org/uniprot/C9RES5 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/579137:METVU_RS03860 ^@ http://purl.uniprot.org/uniprot/C9RGE5 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/579137:METVU_RS01030 ^@ http://purl.uniprot.org/uniprot/C9RES3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/579137:METVU_RS05170 ^@ http://purl.uniprot.org/uniprot/C9RH64 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/579137:METVU_RS00655 ^@ http://purl.uniprot.org/uniprot/C9REK1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS00050 ^@ http://purl.uniprot.org/uniprot/C9RE81 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/579137:METVU_RS03635 ^@ http://purl.uniprot.org/uniprot/C9RG96 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta-RFA-P synthase family.|||Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).|||Homodimer. http://togogenome.org/gene/579137:METVU_RS03645 ^@ http://purl.uniprot.org/uniprot/C9RG98 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. CofH family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.|||The FO synthase complex consists of two subunits, CofG and CofH. http://togogenome.org/gene/579137:METVU_RS07635 ^@ http://purl.uniprot.org/uniprot/C9RDM6 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/579137:METVU_RS02305 ^@ http://purl.uniprot.org/uniprot/C9RFH5 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/579137:METVU_RS04790 ^@ http://purl.uniprot.org/uniprot/C9RGY7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/579137:METVU_RS01895 ^@ http://purl.uniprot.org/uniprot/C9RF95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/579137:METVU_RS04230 ^@ http://purl.uniprot.org/uniprot/C9RGM0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS00005 ^@ http://purl.uniprot.org/uniprot/C9RE72 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/579137:METVU_RS01380 ^@ http://purl.uniprot.org/uniprot/C9REZ4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS07250 ^@ http://purl.uniprot.org/uniprot/C9RIC6 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS31 family.|||Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/579137:METVU_RS02570 ^@ http://purl.uniprot.org/uniprot/C9RFM8 ^@ Caution|||Function|||Similarity ^@ Belongs to the UbiX/PAD1 family.|||Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS06195 ^@ http://purl.uniprot.org/uniprot/C9RHR6 ^@ Caution|||Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.|||In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.|||In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.|||Monomer.|||This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures. http://togogenome.org/gene/579137:METVU_RS07585 ^@ http://purl.uniprot.org/uniprot/C9RDL6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/579137:METVU_RS05620 ^@ http://purl.uniprot.org/uniprot/C9RHF5 ^@ Similarity ^@ Belongs to the CRISPR-associated Csm3 family. http://togogenome.org/gene/579137:METVU_RS08135 ^@ http://purl.uniprot.org/uniprot/C9RDW4 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.|||Cytoplasm|||Heterotetramer of two alpha and two beta chains.|||Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway. http://togogenome.org/gene/579137:METVU_RS07735 ^@ http://purl.uniprot.org/uniprot/C9RDN5 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Monomer. http://togogenome.org/gene/579137:METVU_RS06090 ^@ http://purl.uniprot.org/uniprot/C9RHP6 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/579137:METVU_RS00615 ^@ http://purl.uniprot.org/uniprot/C9REJ2 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/579137:METVU_RS03570 ^@ http://purl.uniprot.org/uniprot/C9RG83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/579137:METVU_RS07530 ^@ http://purl.uniprot.org/uniprot/C9RDK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NusA family.|||Cytoplasm|||Participates in transcription termination. http://togogenome.org/gene/579137:METVU_RS01735 ^@ http://purl.uniprot.org/uniprot/C9RF64 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS19 family.|||May be involved in maturation of the 30S ribosomal subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/579137:METVU_RS06975 ^@ http://purl.uniprot.org/uniprot/C9RI74 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/579137:METVU_RS07555 ^@ http://purl.uniprot.org/uniprot/C9RDL0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.|||Part of the RNA polymerase complex. http://togogenome.org/gene/579137:METVU_RS08700 ^@ http://purl.uniprot.org/uniprot/C9RE67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/579137:METVU_RS00065 ^@ http://purl.uniprot.org/uniprot/C9RE84 ^@ Similarity ^@ Belongs to the TrpC family. http://togogenome.org/gene/579137:METVU_RS01515 ^@ http://purl.uniprot.org/uniprot/C9RF22 ^@ Function|||Similarity|||Subunit ^@ Belongs to the isopentenyl phosphate kinase family.|||Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.|||Homodimer. http://togogenome.org/gene/579137:METVU_RS08005 ^@ http://purl.uniprot.org/uniprot/C9RDU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NucS endonuclease family.|||Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS06515 ^@ http://purl.uniprot.org/uniprot/C9RHY0 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/579137:METVU_RS01875 ^@ http://purl.uniprot.org/uniprot/C9RF91 ^@ Function|||Similarity ^@ Belongs to the uroporphyrinogen-III synthase family.|||Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. http://togogenome.org/gene/579137:METVU_RS05385 ^@ http://purl.uniprot.org/uniprot/C9RHA8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/579137:METVU_RS07945 ^@ http://purl.uniprot.org/uniprot/C9RDS9 ^@ Function|||Similarity ^@ Belongs to the HypA/HybF family.|||Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. http://togogenome.org/gene/579137:METVU_RS00525 ^@ http://purl.uniprot.org/uniprot/C9REH5 ^@ Similarity ^@ Belongs to the Mg-chelatase subunit H family. http://togogenome.org/gene/579137:METVU_RS00930 ^@ http://purl.uniprot.org/uniprot/C9REQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the auxin efflux carrier (TC 2.A.69) family.|||Cell membrane|||Membrane http://togogenome.org/gene/579137:METVU_RS06265 ^@ http://purl.uniprot.org/uniprot/C9RHT0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the diphthine synthase family.|||Homodimer.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/579137:METVU_RS07965 ^@ http://purl.uniprot.org/uniprot/C9RDT3 ^@ Function|||Similarity ^@ Belongs to the V-ATPase F subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/579137:METVU_RS08350 ^@ http://purl.uniprot.org/uniprot/C9RE06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/579137:METVU_RS06385 ^@ http://purl.uniprot.org/uniprot/C9RHV4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/579137:METVU_RS00745 ^@ http://purl.uniprot.org/uniprot/C9REL7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrD family.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/579137:METVU_RS08250 ^@ http://purl.uniprot.org/uniprot/C9RDY7 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent DNA ligase family.|||DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. http://togogenome.org/gene/579137:METVU_RS04330 ^@ http://purl.uniprot.org/uniprot/C9RGP2 ^@ Similarity ^@ Belongs to the UPF0201 family. http://togogenome.org/gene/579137:METVU_RS04580 ^@ http://purl.uniprot.org/uniprot/C9RGU4 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the UPF0165 family. http://togogenome.org/gene/579137:METVU_RS08455 ^@ http://purl.uniprot.org/uniprot/C9RE26 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/579137:METVU_RS06885 ^@ http://purl.uniprot.org/uniprot/C9RI56 ^@ Cofactor|||Similarity ^@ Belongs to the UPF0313 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.