http://togogenome.org/gene/6183:Smp_092280 ^@ http://purl.uniprot.org/uniprot/G4VHX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1A family.|||Nucleus http://togogenome.org/gene/6183:Smp_126080 ^@ http://purl.uniprot.org/uniprot/G4VB17 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/6183:Smp_021280 ^@ http://purl.uniprot.org/uniprot/G4V8I0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARV1 family.|||Endoplasmic reticulum membrane|||Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.|||Membrane http://togogenome.org/gene/6183:Smp_038960 ^@ http://purl.uniprot.org/uniprot/G4VQZ4 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/6183:Smp_026880 ^@ http://purl.uniprot.org/uniprot/G4VFY4 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6183:Smp_025010 ^@ http://purl.uniprot.org/uniprot/G4VM90 ^@ Similarity|||Subunit ^@ Belongs to the casein kinase 2 subunit beta family.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/6183:Smp_126670 ^@ http://purl.uniprot.org/uniprot/G4V7G3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PSMG2 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.|||Forms a heterodimer with PSMG1. http://togogenome.org/gene/6183:Smp_087920 ^@ http://purl.uniprot.org/uniprot/G4VLR7 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. http://togogenome.org/gene/6183:Smp_058140.1 ^@ http://purl.uniprot.org/uniprot/G4VK44|||http://purl.uniprot.org/uniprot/G4VK45 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/6183:Smp_126730 ^@ http://purl.uniprot.org/uniprot/G4V5G4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6183:Smp_004600 ^@ http://purl.uniprot.org/uniprot/G4VHD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/6183:Smp_042780 ^@ http://purl.uniprot.org/uniprot/G4VIT7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 20 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/6183:Smp_210270 ^@ http://purl.uniprot.org/uniprot/G4VHA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGX family.|||Endoplasmic reticulum membrane|||Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. http://togogenome.org/gene/6183:Smp_046790 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KFF4 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/6183:Smp_134880 ^@ http://purl.uniprot.org/uniprot/G4VFS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snurportin family.|||Cytoplasm|||Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.|||Nucleus http://togogenome.org/gene/6183:Smp_064750.1 ^@ http://purl.uniprot.org/uniprot/G4VQ30 ^@ Subunit ^@ Homodimer. Interacts with PKM. http://togogenome.org/gene/6183:Smp_010800 ^@ http://purl.uniprot.org/uniprot/G4VMQ5 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family. http://togogenome.org/gene/6183:Smp_045500 ^@ http://purl.uniprot.org/uniprot/G4VI66 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/6183:Smp_127660 ^@ http://purl.uniprot.org/uniprot/G4VML7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS8 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/6183:Smp_089870 ^@ http://purl.uniprot.org/uniprot/G4VCW3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6183:Smp_140580 ^@ http://purl.uniprot.org/uniprot/G4V9U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/6183:Smp_179250 ^@ http://purl.uniprot.org/uniprot/G4VLD7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/6183:Smp_006850 ^@ http://purl.uniprot.org/uniprot/G4V892 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RPB8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/6183:Smp_075120 ^@ http://purl.uniprot.org/uniprot/G4VH00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PUR DNA-binding protein family.|||Nucleus http://togogenome.org/gene/6183:Smp_068960.1 ^@ http://purl.uniprot.org/uniprot/G4VQA2 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.|||Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF. http://togogenome.org/gene/6183:Smp_034840.1 ^@ http://purl.uniprot.org/uniprot/Q9U491 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/6183:Smp_007000 ^@ http://purl.uniprot.org/uniprot/G4VDF5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS1/PSF1 family.|||Component of the GINS complex.|||Nucleus|||Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. http://togogenome.org/gene/6183:Smp_040130 ^@ http://purl.uniprot.org/uniprot/Q26565 ^@ Activity Regulation|||Function|||Similarity|||Tissue Specificity ^@ Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.|||Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.|||Found mainly in the tegument, gut epithelium, and muscle layers. Also found in the interior of the parasite.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/6183:Smp_096720 ^@ http://purl.uniprot.org/uniprot/G4VJE1 ^@ Similarity ^@ Belongs to the WD repeat WDR91 family. http://togogenome.org/gene/6183:Smp_140560 ^@ http://purl.uniprot.org/uniprot/G4V9U1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_004990 ^@ http://purl.uniprot.org/uniprot/G4V5L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/6183:Smp_007170 ^@ http://purl.uniprot.org/uniprot/G4VB16 ^@ Similarity ^@ Belongs to the Mo25 family. http://togogenome.org/gene/6183:Smp_035580 ^@ http://purl.uniprot.org/uniprot/G4V7P4 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/6183:Smp_025860 ^@ http://purl.uniprot.org/uniprot/G4VAQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||cytoskeleton http://togogenome.org/gene/6183:Smp_021160.1 ^@ http://purl.uniprot.org/uniprot/G4VDK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.|||Nucleus http://togogenome.org/gene/6183:Smp_177080 ^@ http://purl.uniprot.org/uniprot/G4VG79 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.|||Membrane http://togogenome.org/gene/6183:Smp_052390 ^@ http://purl.uniprot.org/uniprot/G4VF05 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_052330 ^@ http://purl.uniprot.org/uniprot/G4VF13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.|||Endoplasmic reticulum membrane|||Required for N-linked oligosaccharide assembly. http://togogenome.org/gene/6183:Smp_094390 ^@ http://purl.uniprot.org/uniprot/G4VDQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/6183:Smp_102410 ^@ http://purl.uniprot.org/uniprot/G4VBF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/6183:Smp_088390 ^@ http://purl.uniprot.org/uniprot/G4VSP2 ^@ Similarity ^@ Belongs to the PITHD1 family. http://togogenome.org/gene/6183:Smp_034100 ^@ http://purl.uniprot.org/uniprot/Q15ES4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/6183:Smp_020040.1 ^@ http://purl.uniprot.org/uniprot/G4V8G1|||http://purl.uniprot.org/uniprot/G4V8G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/6183:Smp_148540 ^@ http://purl.uniprot.org/uniprot/G4V8Y1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Mitochondrion http://togogenome.org/gene/6183:Smp_019880 ^@ http://purl.uniprot.org/uniprot/G4V8G7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.|||Membrane http://togogenome.org/gene/6183:Smp_059480 ^@ http://purl.uniprot.org/uniprot/G4VKD9 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/6183:Smp_075110 ^@ http://purl.uniprot.org/uniprot/G4VH02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad1 family.|||Nucleus http://togogenome.org/gene/6183:Smp_158910 ^@ http://purl.uniprot.org/uniprot/G4VHW3 ^@ Function|||Similarity ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. http://togogenome.org/gene/6183:Smp_066900 ^@ http://purl.uniprot.org/uniprot/G4VIL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||Structural component of the gap junctions.|||gap junction http://togogenome.org/gene/6183:Smp_052350 ^@ http://purl.uniprot.org/uniprot/G4VF10 ^@ Similarity ^@ Belongs to the peptidase C64 family. http://togogenome.org/gene/6183:Smp_005020 ^@ http://purl.uniprot.org/uniprot/G4VQX3 ^@ Domain|||Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.|||The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. http://togogenome.org/gene/6183:Smp_210500 ^@ http://purl.uniprot.org/uniprot/B4XC67 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6183:Smp_086190 ^@ http://purl.uniprot.org/uniprot/G4VCE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/6183:Smp_210830 ^@ http://purl.uniprot.org/uniprot/G4V8R6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/6183:Smp_030870 ^@ http://purl.uniprot.org/uniprot/G4VLT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRAK1BP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/6183:Smp_015850.2 ^@ http://purl.uniprot.org/uniprot/G4VSN5 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/6183:Smp_047060 ^@ http://purl.uniprot.org/uniprot/G4VNA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_055920 ^@ http://purl.uniprot.org/uniprot/G4VB87 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/6183:Smp_053900 ^@ http://purl.uniprot.org/uniprot/G4VHP9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 20 family. http://togogenome.org/gene/6183:Smp_091460 ^@ http://purl.uniprot.org/uniprot/G4V9E4 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/6183:Smp_181100 ^@ http://purl.uniprot.org/uniprot/Q15ES2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OSTC family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/6183:Smp_146210 ^@ http://purl.uniprot.org/uniprot/G4VQR7 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/6183:Smp_035730 ^@ http://purl.uniprot.org/uniprot/G4VHK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP2 family.|||Membrane http://togogenome.org/gene/6183:Smp_012540 ^@ http://purl.uniprot.org/uniprot/G4V975 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/6183:Smp_019030 ^@ http://purl.uniprot.org/uniprot/G4VG42 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C1 family.|||Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains. http://togogenome.org/gene/6183:Smp_046740 ^@ http://purl.uniprot.org/uniprot/G4VCN8 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/6183:Smp_149360 ^@ http://purl.uniprot.org/uniprot/G4VMI7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/6183:Smp_032810 ^@ http://purl.uniprot.org/uniprot/G4VDI4 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/6183:Smp_146800 ^@ http://purl.uniprot.org/uniprot/G4VPP5 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/6183:Smp_047450 ^@ http://purl.uniprot.org/uniprot/G4VBI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. http://togogenome.org/gene/6183:Smp_102840.1 ^@ http://purl.uniprot.org/uniprot/G4VSZ7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/6183:Smp_021800 ^@ http://purl.uniprot.org/uniprot/G4VDV2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/6183:Smp_154530 ^@ http://purl.uniprot.org/uniprot/G4VJX8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ATPase B chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_136320 ^@ http://purl.uniprot.org/uniprot/G4VJX1 ^@ Similarity ^@ Belongs to the GSKIP family. http://togogenome.org/gene/6183:Smp_038410 ^@ http://purl.uniprot.org/uniprot/G4VNU9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SYS1 family.|||Golgi apparatus membrane|||Involved in protein trafficking.|||Membrane http://togogenome.org/gene/6183:Smp_064150 ^@ http://purl.uniprot.org/uniprot/G4VCL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/6183:Smp_160830 ^@ http://purl.uniprot.org/uniprot/G4VFV5 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/6183:Smp_015800 ^@ http://purl.uniprot.org/uniprot/G4VSM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP4 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/6183:Smp_048520.1 ^@ http://purl.uniprot.org/uniprot/G4VSC2 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/6183:Smp_040680 ^@ http://purl.uniprot.org/uniprot/G4VB75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/6183:Smp_018610 ^@ http://purl.uniprot.org/uniprot/G4VGM0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 7 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/6183:Smp_147940.1 ^@ http://purl.uniprot.org/uniprot/G4V8V6 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/6183:Smp_060240 ^@ http://purl.uniprot.org/uniprot/G4VQL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/6183:Smp_079810 ^@ http://purl.uniprot.org/uniprot/G4VFC5 ^@ Similarity ^@ Belongs to the prokaryotic/mitochondrial release factor family. http://togogenome.org/gene/6183:Smp_003770 ^@ http://purl.uniprot.org/uniprot/G4V6K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/6183:Smp_073570 ^@ http://purl.uniprot.org/uniprot/G4V787 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.|||Nucleus http://togogenome.org/gene/6183:Smp_011710 ^@ http://purl.uniprot.org/uniprot/G4VSZ6 ^@ Similarity ^@ Belongs to the AAR2 family. http://togogenome.org/gene/6183:Smp_170340 ^@ http://purl.uniprot.org/uniprot/G4V8A8 ^@ Subcellular Location Annotation ^@ Membrane|||basement membrane http://togogenome.org/gene/6183:Smp_025550 ^@ http://purl.uniprot.org/uniprot/G4VPC6 ^@ Function|||Similarity ^@ Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).|||Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily. http://togogenome.org/gene/6183:Smp_007500.1 ^@ http://purl.uniprot.org/uniprot/G4VF21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Membrane http://togogenome.org/gene/6183:Smp_003410 ^@ http://purl.uniprot.org/uniprot/G4V6P4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/6183:Smp_092390 ^@ http://purl.uniprot.org/uniprot/G4VHY4 ^@ Similarity ^@ Belongs to the eukaryotic-type N-acetylglucosamine kinase family. http://togogenome.org/gene/6183:Smp_042990.1 ^@ http://purl.uniprot.org/uniprot/G4VIV5 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM63 subfamily.|||Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. http://togogenome.org/gene/6183:Smp_119980 ^@ http://purl.uniprot.org/uniprot/G4VMU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC62 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6183:Smp_013300.1 ^@ http://purl.uniprot.org/uniprot/G4VEH8|||http://purl.uniprot.org/uniprot/G4VEH9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/6183:Smp_093630.1 ^@ http://purl.uniprot.org/uniprot/G4V9Q5|||http://purl.uniprot.org/uniprot/G4V9Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/6183:Smp_002160 ^@ http://purl.uniprot.org/uniprot/G4VLL1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_066940 ^@ http://purl.uniprot.org/uniprot/G4VIK8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL29 family. http://togogenome.org/gene/6183:Smp_126140 ^@ http://purl.uniprot.org/uniprot/C4PYZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/6183:Smp_006740 ^@ http://purl.uniprot.org/uniprot/G4V9U9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/6183:Smp_166930 ^@ http://purl.uniprot.org/uniprot/G4VC98 ^@ Subcellular Location Annotation ^@ Lysosome membrane http://togogenome.org/gene/6183:Smp_012470 ^@ http://purl.uniprot.org/uniprot/G4V969 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/6183:Smp_138240 ^@ http://purl.uniprot.org/uniprot/G4VFH0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_006250.1 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KBW6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_048430 ^@ http://purl.uniprot.org/uniprot/Q962Y6 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/6183:Smp_065890 ^@ http://purl.uniprot.org/uniprot/G4VPA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tollip family.|||Cytoplasm http://togogenome.org/gene/6183:Smp_068840 ^@ http://purl.uniprot.org/uniprot/G4VQ39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HOP2 family.|||Nucleus http://togogenome.org/gene/6183:Smp_096480 ^@ http://purl.uniprot.org/uniprot/G4VR43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/6183:Smp_073790 ^@ http://purl.uniprot.org/uniprot/G4V6Z2 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/6183:Smp_040710 ^@ http://purl.uniprot.org/uniprot/G4VFR0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.|||Nucleus http://togogenome.org/gene/6183:Smp_012010 ^@ http://purl.uniprot.org/uniprot/A6XDL3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_099690 ^@ http://purl.uniprot.org/uniprot/G4VBM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RER1 family.|||Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.|||Membrane http://togogenome.org/gene/6183:Smp_123170 ^@ http://purl.uniprot.org/uniprot/A0A5K4FEH6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/6183:Smp_089570 ^@ http://purl.uniprot.org/uniprot/G4V5T6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAMP4 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/6183:Smp_052060 ^@ http://purl.uniprot.org/uniprot/G4VI16 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with an ATP-specific beta subunit, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with a GTP-specific beta subunit forms a GDP-forming succinyl-CoA synthetase (G-SCS).|||Mitochondrion|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. http://togogenome.org/gene/6183:Smp_052500 ^@ http://purl.uniprot.org/uniprot/G4VHN9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_132020 ^@ http://purl.uniprot.org/uniprot/G4VNY6 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/6183:Smp_091170 ^@ http://purl.uniprot.org/uniprot/G4VRI9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/6183:Smp_069810 ^@ http://purl.uniprot.org/uniprot/G4VK58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM129 family.|||Membrane http://togogenome.org/gene/6183:Smp_063350 ^@ http://purl.uniprot.org/uniprot/G4VF81 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL27 family. http://togogenome.org/gene/6183:Smp_013040.1 ^@ http://purl.uniprot.org/uniprot/G4VEV6 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/6183:Smp_029900.1 ^@ http://purl.uniprot.org/uniprot/G4VFI9 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/6183:Smp_097380 ^@ http://purl.uniprot.org/uniprot/G4VML2 ^@ Similarity ^@ Belongs to the GroES chaperonin family. http://togogenome.org/gene/6183:Smp_033040 ^@ http://purl.uniprot.org/uniprot/G4VRF8 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. http://togogenome.org/gene/6183:Smp_063250.1 ^@ http://purl.uniprot.org/uniprot/G4VF91 ^@ Similarity ^@ Belongs to the CBP3 family. http://togogenome.org/gene/6183:Smp_058990 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KGF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MND1 family.|||Nucleus|||Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. http://togogenome.org/gene/6183:Smp_012750 ^@ http://purl.uniprot.org/uniprot/G4V9G5 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL11 family.|||Binds directly to 26S ribosomal RNA. http://togogenome.org/gene/6183:Smp_160870 ^@ http://purl.uniprot.org/uniprot/G4VFW1 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/6183:Smp_159490 ^@ http://purl.uniprot.org/uniprot/G4VQ97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/6183:Smp_127100 ^@ http://purl.uniprot.org/uniprot/G4VL32 ^@ Similarity ^@ Belongs to the SUA5 family. http://togogenome.org/gene/6183:Smp_037930 ^@ http://purl.uniprot.org/uniprot/G4VQY8 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/6183:Smp_004220 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KBP6 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/6183:Smp_073500.1 ^@ http://purl.uniprot.org/uniprot/G4V780 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/6183:Smp_055740 ^@ http://purl.uniprot.org/uniprot/G4VHK0 ^@ Similarity ^@ Belongs to the nanos family. http://togogenome.org/gene/6183:Smp_121320 ^@ http://purl.uniprot.org/uniprot/G4VAT9 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in spermatogenesis.|||Nucleus http://togogenome.org/gene/6183:Smp_015730 ^@ http://purl.uniprot.org/uniprot/G4VSL8 ^@ Similarity ^@ Belongs to the complex I NDUFB6 subunit family. http://togogenome.org/gene/6183:Smp_086860 ^@ http://purl.uniprot.org/uniprot/G4V8L9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6183:Smp_067810 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KH75 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6183:Smp_030910 ^@ http://purl.uniprot.org/uniprot/G4VLT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/6183:Smp_015980 ^@ http://purl.uniprot.org/uniprot/G4VJN6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase e subunit family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/6183:KEF69_p12 ^@ http://purl.uniprot.org/uniprot/Q9B8X8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_032820.1 ^@ http://purl.uniprot.org/uniprot/G4VDI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SMU1 family.|||Nucleus speckle http://togogenome.org/gene/6183:Smp_079240 ^@ http://purl.uniprot.org/uniprot/G4V790 ^@ Function|||Similarity ^@ Belongs to the dUTPase family.|||Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/6183:Smp_070190 ^@ http://purl.uniprot.org/uniprot/G4VJB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. GCN5 subfamily.|||centrosome http://togogenome.org/gene/6183:Smp_128200.1 ^@ http://purl.uniprot.org/uniprot/G4VD81 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/6183:Smp_064050.1 ^@ http://purl.uniprot.org/uniprot/G4VIM8 ^@ Similarity ^@ Belongs to the RuvB family. http://togogenome.org/gene/6183:Smp_067250.1 ^@ http://purl.uniprot.org/uniprot/G4V9P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC5 family.|||Nucleus http://togogenome.org/gene/6183:Smp_052460 ^@ http://purl.uniprot.org/uniprot/G4VHP1 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/6183:Smp_166280 ^@ http://purl.uniprot.org/uniprot/G4VD11 ^@ Similarity ^@ Belongs to the glutaminyl-peptide cyclotransferase family. http://togogenome.org/gene/6183:Smp_129160 ^@ http://purl.uniprot.org/uniprot/G4VEV8 ^@ Similarity ^@ Belongs to the NRDE2 family. http://togogenome.org/gene/6183:Smp_024060.1 ^@ http://purl.uniprot.org/uniprot/G4VQ51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 31 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/6183:Smp_120980 ^@ http://purl.uniprot.org/uniprot/G4VFM1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/6183:Smp_038510.1 ^@ http://purl.uniprot.org/uniprot/G4VTG3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/6183:Smp_154690 ^@ http://purl.uniprot.org/uniprot/G4V6H6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/6183:Smp_082710.1 ^@ http://purl.uniprot.org/uniprot/G4VC87 ^@ Similarity ^@ Belongs to the glycosyltransferase 28 family. http://togogenome.org/gene/6183:Smp_064860 ^@ http://purl.uniprot.org/uniprot/G4VPU9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/6183:Smp_183710 ^@ http://purl.uniprot.org/uniprot/G4VLW1 ^@ Function|||Similarity ^@ Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.|||Belongs to the actin family. http://togogenome.org/gene/6183:Smp_024120 ^@ http://purl.uniprot.org/uniprot/O01374 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRB/QCR7 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Mitochondrion inner membrane|||Was originally thought to be the ubiquinone-binding protein (QP-C). http://togogenome.org/gene/6183:Smp_030290 ^@ http://purl.uniprot.org/uniprot/G4VFN5 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/6183:Smp_044010.1 ^@ http://purl.uniprot.org/uniprot/P42637 ^@ Developmental Stage|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the tropomyosin family.|||Expressed at much higher levels in the adult worm stage as compared to the cercariae and the egg stages.|||Homodimer.|||The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.|||Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. http://togogenome.org/gene/6183:Smp_011120 ^@ http://purl.uniprot.org/uniprot/G4VD99 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).|||Cytoplasm http://togogenome.org/gene/6183:Smp_042160.1 ^@ http://purl.uniprot.org/uniprot/P53442 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/6183:Smp_145290 ^@ http://purl.uniprot.org/uniprot/G4VIT0 ^@ Cofactor|||Similarity ^@ Belongs to the alkaline phosphatase family.|||Binds 1 Mg(2+) ion.|||Binds 2 Zn(2+) ions. http://togogenome.org/gene/6183:Smp_093670 ^@ http://purl.uniprot.org/uniprot/G4V9Q8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATG12 family.|||Forms a conjugate with ATG5.|||Ubiquitin-like protein involved in autophagic vesicle formation. http://togogenome.org/gene/6183:Smp_064950 ^@ http://purl.uniprot.org/uniprot/G4VPT6 ^@ Similarity ^@ Belongs to the calcineurin regulatory subunit family. http://togogenome.org/gene/6183:Smp_060220 ^@ http://purl.uniprot.org/uniprot/G4VQL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/6183:Smp_049550 ^@ http://purl.uniprot.org/uniprot/G4V910 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/6183:Smp_083180.1 ^@ http://purl.uniprot.org/uniprot/G4V7F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP23/FCF1 family. FCF1 subfamily.|||nucleolus http://togogenome.org/gene/6183:Smp_059980 ^@ http://purl.uniprot.org/uniprot/Q6WVP6 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/6183:Smp_023660 ^@ http://purl.uniprot.org/uniprot/G4VFT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MPP10 family.|||nucleolus http://togogenome.org/gene/6183:Smp_042790 ^@ http://purl.uniprot.org/uniprot/G4VIT8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum|||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins. http://togogenome.org/gene/6183:Smp_013070 ^@ http://purl.uniprot.org/uniprot/G4VEW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/6183:Smp_154680 ^@ http://purl.uniprot.org/uniprot/G4V6I0 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/6183:Smp_096290.1 ^@ http://purl.uniprot.org/uniprot/G4VS51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM256 family.|||Membrane http://togogenome.org/gene/6183:Smp_053390 ^@ http://purl.uniprot.org/uniprot/C4QBN1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6183:Smp_001530 ^@ http://purl.uniprot.org/uniprot/G4VCF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EXO84 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||growth cone|||perinuclear region http://togogenome.org/gene/6183:Smp_170840 ^@ http://purl.uniprot.org/uniprot/G4VLE1 ^@ Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer. http://togogenome.org/gene/6183:Smp_083040.1 ^@ http://purl.uniprot.org/uniprot/G4V775|||http://purl.uniprot.org/uniprot/G4V776 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/6183:Smp_065110 ^@ http://purl.uniprot.org/uniprot/A0A5K4F3M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LETM1 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_074470 ^@ http://purl.uniprot.org/uniprot/G4VRC6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/6183:Smp_048830 ^@ http://purl.uniprot.org/uniprot/G4VBY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB3 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_037460.1 ^@ http://purl.uniprot.org/uniprot/G4VE54 ^@ Similarity ^@ Belongs to the SAS10 family. http://togogenome.org/gene/6183:Smp_181000 ^@ http://purl.uniprot.org/uniprot/G4VDY7 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. http://togogenome.org/gene/6183:Smp_053610 ^@ http://purl.uniprot.org/uniprot/G4VIZ9 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. http://togogenome.org/gene/6183:Smp_060270 ^@ http://purl.uniprot.org/uniprot/G4VQM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the jagunal family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6183:Smp_021140 ^@ http://purl.uniprot.org/uniprot/G4VDK2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS7 family. http://togogenome.org/gene/6183:KEF69_p01 ^@ http://purl.uniprot.org/uniprot/Q9B8X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 1 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_102280 ^@ http://purl.uniprot.org/uniprot/G4VDE9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/6183:Smp_160670 ^@ http://purl.uniprot.org/uniprot/G4VJ65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/6183:Smp_046090.1 ^@ http://purl.uniprot.org/uniprot/G4VPS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/6183:Smp_059870.1 ^@ http://purl.uniprot.org/uniprot/G4VT25 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.|||Cytoplasm|||May play a role in chaperone-mediated protein folding. http://togogenome.org/gene/6183:Smp_084910 ^@ http://purl.uniprot.org/uniprot/G4VFF6 ^@ Similarity ^@ Belongs to the FMC1 family. http://togogenome.org/gene/6183:KEF69_p02 ^@ http://purl.uniprot.org/uniprot/Q9MD44 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 3 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.|||Mitochondrion membrane http://togogenome.org/gene/6183:Smp_054310 ^@ http://purl.uniprot.org/uniprot/G4VQK6 ^@ Similarity ^@ Belongs to the peptidase M50A family. http://togogenome.org/gene/6183:Smp_089290 ^@ http://purl.uniprot.org/uniprot/G4VLE3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/6183:Smp_015900 ^@ http://purl.uniprot.org/uniprot/G4VJP1 ^@ Similarity ^@ Belongs to the Iojap/RsfS family. http://togogenome.org/gene/6183:KEF69_p07 ^@ http://purl.uniprot.org/uniprot/Q9B8X5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_180000 ^@ http://purl.uniprot.org/uniprot/G4VTQ8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/6183:Smp_174130 ^@ http://purl.uniprot.org/uniprot/G4VTT7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_210260 ^@ http://purl.uniprot.org/uniprot/A0A5K4F2G7 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/6183:Smp_121790.1 ^@ http://purl.uniprot.org/uniprot/G4VGE1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/6183:Smp_070710 ^@ http://purl.uniprot.org/uniprot/G4VEL6 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/6183:Smp_062610.1 ^@ http://purl.uniprot.org/uniprot/G4VJK8 ^@ Similarity ^@ Belongs to the ATG101 family. http://togogenome.org/gene/6183:Smp_083780 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KIK2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_169870 ^@ http://purl.uniprot.org/uniprot/G4VMC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cystinosin family.|||Membrane http://togogenome.org/gene/6183:Smp_047660 ^@ http://purl.uniprot.org/uniprot/G4VBG5 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/6183:Smp_087940.1 ^@ http://purl.uniprot.org/uniprot/G4VLS0 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/6183:KEF69_p06 ^@ http://purl.uniprot.org/uniprot/Q9B8X4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane http://togogenome.org/gene/6183:Smp_198520 ^@ http://purl.uniprot.org/uniprot/G4VS25 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TAF8 family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6183:Smp_160780 ^@ http://purl.uniprot.org/uniprot/G4V7X8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_046980 ^@ http://purl.uniprot.org/uniprot/G4VNB2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||Nucleus|||Required for pre-mRNA splicing. http://togogenome.org/gene/6183:Smp_063580.1 ^@ http://purl.uniprot.org/uniprot/G4VA08 ^@ Similarity ^@ Belongs to the acetyltransferase family. MAK3 subfamily. http://togogenome.org/gene/6183:Smp_058240 ^@ http://purl.uniprot.org/uniprot/G4VNM5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6183:Smp_024590 ^@ http://purl.uniprot.org/uniprot/G4VIQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP19 family.|||Cytoplasm http://togogenome.org/gene/6183:Smp_172850 ^@ http://purl.uniprot.org/uniprot/G4V5E8 ^@ Function|||Subcellular Location Annotation ^@ Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/6183:Smp_086590 ^@ http://purl.uniprot.org/uniprot/G4VGX1 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/6183:Smp_169610 ^@ http://purl.uniprot.org/uniprot/G4VJH0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/6183:Smp_151070 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KPW2 ^@ Similarity ^@ Belongs to the SPT5 family. http://togogenome.org/gene/6183:Smp_063420 ^@ http://purl.uniprot.org/uniprot/G4VF75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/6183:Smp_080150 ^@ http://purl.uniprot.org/uniprot/G4VJM1 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/6183:Smp_123010 ^@ http://purl.uniprot.org/uniprot/G4VCH8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_163840 ^@ http://purl.uniprot.org/uniprot/G4VTM0 ^@ Similarity ^@ Belongs to the TPRG1 family. http://togogenome.org/gene/6183:Smp_130850 ^@ http://purl.uniprot.org/uniprot/G4VJN9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS19 family. http://togogenome.org/gene/6183:Smp_077850 ^@ http://purl.uniprot.org/uniprot/G4VL76 ^@ Function|||Similarity ^@ Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.|||Belongs to the actin family. http://togogenome.org/gene/6183:Smp_046120 ^@ http://purl.uniprot.org/uniprot/G4VPT0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_033950.1 ^@ http://purl.uniprot.org/uniprot/Q6UEH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/6183:Smp_100140 ^@ http://purl.uniprot.org/uniprot/G4VG84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KRTCAP2 family.|||Membrane http://togogenome.org/gene/6183:Smp_082420 ^@ http://purl.uniprot.org/uniprot/G4VGH9 ^@ Caution|||Similarity|||Subunit ^@ Although this protein has high similarity to uridine phosphorylases, it has no detectable catalytic activity. It contains substitutions at Gly-126 and Gln-201, two conserved sites which are known to be important for uridine binding.|||Belongs to the PNP/UDP phosphorylase family.|||Homodimer. http://togogenome.org/gene/6183:Smp_060090.1 ^@ http://purl.uniprot.org/uniprot/G4VAJ9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family. http://togogenome.org/gene/6183:Smp_028100.1 ^@ http://purl.uniprot.org/uniprot/G4V624 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/6183:Smp_020370 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KD50 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6183:Smp_006340 ^@ http://purl.uniprot.org/uniprot/G4VR33 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC4 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6183:Smp_006680 ^@ http://purl.uniprot.org/uniprot/G4V9W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDCD10 family.|||Cytoplasm http://togogenome.org/gene/6183:Smp_000830 ^@ http://purl.uniprot.org/uniprot/G4V658 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_031000.1 ^@ http://purl.uniprot.org/uniprot/G4VPI9 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/6183:Smp_035430.1 ^@ http://purl.uniprot.org/uniprot/G4V7Y4 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family. http://togogenome.org/gene/6183:Smp_079910 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KIA0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFIIE beta subunit family.|||Nucleus|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.|||Tetramer of two alpha and two beta chains. http://togogenome.org/gene/6183:Smp_064640 ^@ http://purl.uniprot.org/uniprot/G4VNR3 ^@ Similarity ^@ Belongs to the RRM TRSPAP family. http://togogenome.org/gene/6183:Smp_030920.1 ^@ http://purl.uniprot.org/uniprot/G4VLT9|||http://purl.uniprot.org/uniprot/G4VLU0 ^@ Similarity ^@ Belongs to the Tom22 family. http://togogenome.org/gene/6183:Smp_123240 ^@ http://purl.uniprot.org/uniprot/G4VLK9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/6183:Smp_153790 ^@ http://purl.uniprot.org/uniprot/G4VJ35 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/6183:Smp_170450 ^@ http://purl.uniprot.org/uniprot/G4VDQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/6183:Smp_007290 ^@ http://purl.uniprot.org/uniprot/G4VB04 ^@ Function|||Similarity ^@ Belongs to the YdjC deacetylase family.|||Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides. http://togogenome.org/gene/6183:Smp_014800.1 ^@ http://purl.uniprot.org/uniprot/G4VBX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/6183:Smp_017660 ^@ http://purl.uniprot.org/uniprot/C1LZ83 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/6183:Smp_168770 ^@ http://purl.uniprot.org/uniprot/G4VF32 ^@ Similarity ^@ Belongs to the TIM16/PAM16 family. http://togogenome.org/gene/6183:Smp_086480 ^@ http://purl.uniprot.org/uniprot/P32070 ^@ Developmental Stage ^@ Occurs in similar relative abundances in infected hepatopancreas, schistosomula and adults. http://togogenome.org/gene/6183:Smp_045710.1 ^@ http://purl.uniprot.org/uniprot/G4VK88 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/6183:Smp_028140 ^@ http://purl.uniprot.org/uniprot/G4V620 ^@ Similarity ^@ Belongs to the FCHO family. http://togogenome.org/gene/6183:Smp_158430 ^@ http://purl.uniprot.org/uniprot/G4V5B9 ^@ Similarity ^@ Belongs to the RNase T2 family. http://togogenome.org/gene/6183:Smp_061870 ^@ http://purl.uniprot.org/uniprot/G4VNI0 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rieske iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Membrane|||Mitochondrion inner membrane|||The Rieske protein is a high potential 2Fe-2S protein. http://togogenome.org/gene/6183:Smp_044160 ^@ http://purl.uniprot.org/uniprot/G4VEJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/6183:Smp_031010 ^@ http://purl.uniprot.org/uniprot/G4VPJ1 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/6183:Smp_066520 ^@ http://purl.uniprot.org/uniprot/G4VM02 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/6183:Smp_115450 ^@ http://purl.uniprot.org/uniprot/G4VND4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP5 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/6183:Smp_072180 ^@ http://purl.uniprot.org/uniprot/G4V9D2 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/6183:Smp_143470.1 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KNV9 ^@ Similarity ^@ Belongs to the spectrin family. http://togogenome.org/gene/6183:Smp_007890.1 ^@ http://purl.uniprot.org/uniprot/G4V5P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC9 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/6183:Smp_168330 ^@ http://purl.uniprot.org/uniprot/G4VES0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/6183:Smp_007260.1 ^@ http://purl.uniprot.org/uniprot/Q27779 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/6183:Smp_200410 ^@ http://purl.uniprot.org/uniprot/G4V8Q8 ^@ Similarity ^@ Belongs to the thymidylate synthase family. http://togogenome.org/gene/6183:Smp_145140 ^@ http://purl.uniprot.org/uniprot/G4VJE5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/6183:Smp_090120.1 ^@ http://purl.uniprot.org/uniprot/Q26595 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/6183:Smp_053040 ^@ http://purl.uniprot.org/uniprot/G4VK08 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/6183:Smp_093450 ^@ http://purl.uniprot.org/uniprot/G4VHT5 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/6183:Smp_003990 ^@ http://purl.uniprot.org/uniprot/G4V6B9 ^@ Similarity|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Homodimer. http://togogenome.org/gene/6183:Smp_057320 ^@ http://purl.uniprot.org/uniprot/G4VMW9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. http://togogenome.org/gene/6183:Smp_047370 ^@ http://purl.uniprot.org/uniprot/G4VBJ0 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Homodimer. http://togogenome.org/gene/6183:Smp_092380 ^@ http://purl.uniprot.org/uniprot/G4VHY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/6183:Smp_049150 ^@ http://purl.uniprot.org/uniprot/G4VC15 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/6183:Smp_086760 ^@ http://purl.uniprot.org/uniprot/G4VKL5 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/6183:Smp_022430 ^@ http://purl.uniprot.org/uniprot/G4VPA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_151510 ^@ http://purl.uniprot.org/uniprot/G4VH69 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPF family.|||Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).|||Interacts with EME1.|||Nucleus http://togogenome.org/gene/6183:Smp_041650 ^@ http://purl.uniprot.org/uniprot/G4VN01 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family. http://togogenome.org/gene/6183:Smp_018030 ^@ http://purl.uniprot.org/uniprot/G4VNZ6 ^@ Similarity ^@ Belongs to the VPS72/YL1 family. http://togogenome.org/gene/6183:Smp_035790 ^@ http://purl.uniprot.org/uniprot/G4VMB5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/6183:Smp_046160 ^@ http://purl.uniprot.org/uniprot/G4VPT3 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 2 family. http://togogenome.org/gene/6183:Smp_083150.1 ^@ http://purl.uniprot.org/uniprot/G4V7E6 ^@ Similarity ^@ Belongs to the GPATCH11 family. http://togogenome.org/gene/6183:Smp_021540 ^@ http://purl.uniprot.org/uniprot/G4VNH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BBP/SF1 family.|||Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.|||Nucleus http://togogenome.org/gene/6183:Smp_081250 ^@ http://purl.uniprot.org/uniprot/G4V8N9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_055450 ^@ http://purl.uniprot.org/uniprot/G4V5W4 ^@ Similarity ^@ Belongs to the LAMTOR4 family. http://togogenome.org/gene/6183:Smp_049000 ^@ http://purl.uniprot.org/uniprot/G4VC03 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_171660 ^@ http://purl.uniprot.org/uniprot/G4VP78 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6183:Smp_027040 ^@ http://purl.uniprot.org/uniprot/G4VG01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/6183:Smp_105370 ^@ http://purl.uniprot.org/uniprot/G4V5E2 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6183:Smp_008440 ^@ http://purl.uniprot.org/uniprot/G4V5H2 ^@ Similarity ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family. http://togogenome.org/gene/6183:Smp_095520 ^@ http://purl.uniprot.org/uniprot/Q94758 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Acts as a non-catalytic accessory component of a dynein complex.|||Belongs to the dynein light chain family.|||Schistosomula, lung stage worms, and adult worms.|||Tegument.|||cytoskeleton http://togogenome.org/gene/6183:Smp_043340 ^@ http://purl.uniprot.org/uniprot/G4VIY8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6183:Smp_090860 ^@ http://purl.uniprot.org/uniprot/G4V8L2 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. http://togogenome.org/gene/6183:Smp_039400 ^@ http://purl.uniprot.org/uniprot/G4VDD2 ^@ Function|||PTM|||Similarity ^@ Belongs to the eIF-5A family.|||Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group. http://togogenome.org/gene/6183:Smp_129340 ^@ http://purl.uniprot.org/uniprot/C4Q0P6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat LIS1/nudF family.|||Dimerization mediated by the LisH domain may be required to activate dynein.|||Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes.|||centrosome|||cytoskeleton http://togogenome.org/gene/6183:Smp_063650.3 ^@ http://purl.uniprot.org/uniprot/A0A5K4EGG5 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/6183:Smp_059810 ^@ http://purl.uniprot.org/uniprot/G4V9A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC7 family.|||Nucleus http://togogenome.org/gene/6183:Smp_030180 ^@ http://purl.uniprot.org/uniprot/G4VFM6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.|||Belongs to the URM1 family.|||C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3/UBA4 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3/UBA4 homolog.|||Cytoplasm http://togogenome.org/gene/6183:Smp_037120 ^@ http://purl.uniprot.org/uniprot/G4VRH7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/6183:Smp_080420 ^@ http://purl.uniprot.org/uniprot/G4VTP8 ^@ Similarity ^@ Belongs to the bZIP family. Jun subfamily. http://togogenome.org/gene/6183:Smp_029060 ^@ http://purl.uniprot.org/uniprot/G4VGT4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.|||Component of a multi-subunit COQ enzyme complex.|||Mitochondrion inner membrane|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. http://togogenome.org/gene/6183:Smp_068100 ^@ http://purl.uniprot.org/uniprot/G4V6Q1 ^@ Similarity ^@ Belongs to the MFAP1 family. http://togogenome.org/gene/6183:Smp_069770 ^@ http://purl.uniprot.org/uniprot/G4VK53 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/6183:Smp_128120 ^@ http://purl.uniprot.org/uniprot/G4VD97 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_075280.1 ^@ http://purl.uniprot.org/uniprot/G4VS68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/6183:Smp_118750 ^@ http://purl.uniprot.org/uniprot/G4VPK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELOF1 family.|||Nucleus|||Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. http://togogenome.org/gene/6183:Smp_044580 ^@ http://purl.uniprot.org/uniprot/G4VQR9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/6183:Smp_007760 ^@ http://purl.uniprot.org/uniprot/G4VPX8 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/6183:Smp_009320.1 ^@ http://purl.uniprot.org/uniprot/G4VL25 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/6183:Smp_071390 ^@ http://purl.uniprot.org/uniprot/G4V9S0 ^@ Similarity ^@ Belongs to the adenylate kinase family. http://togogenome.org/gene/6183:Smp_078750.1 ^@ http://purl.uniprot.org/uniprot/G4VFD9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_012800 ^@ http://purl.uniprot.org/uniprot/G4V9G9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_042210 ^@ http://purl.uniprot.org/uniprot/G4VJU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC4 family.|||Component of the origin recognition complex (ORC) that binds origins of replication.|||Nucleus http://togogenome.org/gene/6183:Smp_142390 ^@ http://purl.uniprot.org/uniprot/G4VE56 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Structural component of the gap junctions.|||gap junction http://togogenome.org/gene/6183:Smp_094950 ^@ http://purl.uniprot.org/uniprot/G4VRY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/6183:Smp_067780 ^@ http://purl.uniprot.org/uniprot/G4VHW7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/6183:Smp_035800 ^@ http://purl.uniprot.org/uniprot/O44125 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA. http://togogenome.org/gene/6183:Smp_171620 ^@ http://purl.uniprot.org/uniprot/G4VP86 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Cytoplasm|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/6183:Smp_129420 ^@ http://purl.uniprot.org/uniprot/G4VH52 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/6183:Smp_004640 ^@ http://purl.uniprot.org/uniprot/G4VD46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.|||Virion http://togogenome.org/gene/6183:Smp_093230 ^@ http://purl.uniprot.org/uniprot/G4V8Q5 ^@ Function|||Similarity ^@ Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.|||Belongs to the actin family. http://togogenome.org/gene/6183:Smp_058320 ^@ http://purl.uniprot.org/uniprot/G4VNL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NASP family.|||Nucleus http://togogenome.org/gene/6183:Smp_150040.1 ^@ http://purl.uniprot.org/uniprot/G4VI20 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/6183:Smp_001590.1 ^@ http://purl.uniprot.org/uniprot/G4VCG3 ^@ Function|||Subcellular Location Annotation ^@ Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Membrane|||Mitochondrion inner membrane|||Nucleus http://togogenome.org/gene/6183:Smp_024850 ^@ http://purl.uniprot.org/uniprot/G4VMA5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/6183:Smp_003930 ^@ http://purl.uniprot.org/uniprot/G4V6C8 ^@ Similarity ^@ Belongs to the IFT56 family. http://togogenome.org/gene/6183:Smp_017070 ^@ http://purl.uniprot.org/uniprot/G4VTJ6 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/6183:Smp_023160 ^@ http://purl.uniprot.org/uniprot/G4VCC0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase F subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/6183:Smp_210440 ^@ http://purl.uniprot.org/uniprot/G4VAZ9 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/6183:Smp_017280 ^@ http://purl.uniprot.org/uniprot/Q15ER5 ^@ Similarity ^@ In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family. http://togogenome.org/gene/6183:Smp_045200 ^@ http://purl.uniprot.org/uniprot/P14202 ^@ Developmental Stage|||Tissue Specificity ^@ Adult and schistosomula tegument.|||This antigen occurs in adults and sporocysts but not in cercariae, eggs or newly transformed schistosomula. It is a developmentally regulated protein. http://togogenome.org/gene/6183:Smp_071830 ^@ http://purl.uniprot.org/uniprot/C4QGM3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity).|||TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. http://togogenome.org/gene/6183:Smp_004630 ^@ http://purl.uniprot.org/uniprot/G4VHD5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_083080.1 ^@ http://purl.uniprot.org/uniprot/G4V7D8 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/6183:Smp_009520 ^@ http://purl.uniprot.org/uniprot/G4V9R9 ^@ Function|||Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). http://togogenome.org/gene/6183:Smp_054360 ^@ http://purl.uniprot.org/uniprot/G4VQJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm http://togogenome.org/gene/6183:Smp_170030 ^@ http://purl.uniprot.org/uniprot/G4VTS1 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/6183:Smp_015860 ^@ http://purl.uniprot.org/uniprot/G4VSN6 ^@ Function|||Similarity ^@ Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis. http://togogenome.org/gene/6183:Smp_156410 ^@ http://purl.uniprot.org/uniprot/G4VA06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.|||Membrane http://togogenome.org/gene/6183:Smp_040560 ^@ http://purl.uniprot.org/uniprot/G4VB67 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. http://togogenome.org/gene/6183:Smp_143490 ^@ http://purl.uniprot.org/uniprot/G4VDE3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/6183:Smp_008310 ^@ http://purl.uniprot.org/uniprot/G4V7H1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_203810 ^@ http://purl.uniprot.org/uniprot/G4VQL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/6183:Smp_056200 ^@ http://purl.uniprot.org/uniprot/G4V5Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Mitochondrion http://togogenome.org/gene/6183:Smp_164100 ^@ http://purl.uniprot.org/uniprot/G4VL69 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/6183:Smp_032310 ^@ http://purl.uniprot.org/uniprot/G4VSI1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC3 family.|||Component of the Arp2/3 complex.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/6183:Smp_136400 ^@ http://purl.uniprot.org/uniprot/G4VEX7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_049390 ^@ http://purl.uniprot.org/uniprot/G4V8Z5 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/6183:Smp_040790 ^@ http://purl.uniprot.org/uniprot/G4VFQ0 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/6183:Smp_054540 ^@ http://purl.uniprot.org/uniprot/G4VQH7 ^@ Similarity ^@ Belongs to the MAPRE family. http://togogenome.org/gene/6183:Smp_103810.1 ^@ http://purl.uniprot.org/uniprot/G4VCQ2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/6183:Smp_046800.1 ^@ http://purl.uniprot.org/uniprot/G4VCN1 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/6183:Smp_091640 ^@ http://purl.uniprot.org/uniprot/G4VLN8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/6183:Smp_201060 ^@ http://purl.uniprot.org/uniprot/Q94748 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a non-catalytic accessory component of a dynein complex.|||Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/6183:Smp_136730 ^@ http://purl.uniprot.org/uniprot/G4VFY7 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/6183:Smp_008260 ^@ http://purl.uniprot.org/uniprot/G4V7H6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/6183:Smp_082860 ^@ http://purl.uniprot.org/uniprot/G4VC69 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/6183:Smp_082850.1 ^@ http://purl.uniprot.org/uniprot/G4VC71 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/6183:Smp_082490 ^@ http://purl.uniprot.org/uniprot/G4VGI8 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/6183:Smp_011720 ^@ http://purl.uniprot.org/uniprot/G4VSZ9 ^@ Similarity ^@ Belongs to the PHF5 family. http://togogenome.org/gene/6183:Smp_143460 ^@ http://purl.uniprot.org/uniprot/G4VDE7 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/6183:Smp_004190 ^@ http://purl.uniprot.org/uniprot/G4VCI8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_048970.1 ^@ http://purl.uniprot.org/uniprot/G4VC00 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 4 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/6183:Smp_013470.1 ^@ http://purl.uniprot.org/uniprot/G4VH46 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/6183:Smp_099850.3 ^@ http://purl.uniprot.org/uniprot/G4VAD4 ^@ Similarity ^@ Belongs to the NRAMP family. http://togogenome.org/gene/6183:Smp_075130 ^@ http://purl.uniprot.org/uniprot/G4VGZ9 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/6183:Smp_095010 ^@ http://purl.uniprot.org/uniprot/G4VRY8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_023270.1 ^@ http://purl.uniprot.org/uniprot/G4VCA6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_174950 ^@ http://purl.uniprot.org/uniprot/G4VR71 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS19 family. http://togogenome.org/gene/6183:Smp_164380 ^@ http://purl.uniprot.org/uniprot/G4VLY7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/6183:Smp_150210.1 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KPS2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_174510 ^@ http://purl.uniprot.org/uniprot/G4V850 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/6183:Smp_017880 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KCU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/6183:Smp_029100.1 ^@ http://purl.uniprot.org/uniprot/G4VGT9 ^@ Similarity ^@ Belongs to the TRM112 family. http://togogenome.org/gene/6183:Smp_210250 ^@ http://purl.uniprot.org/uniprot/A0A5K4F037 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/6183:Smp_010100 ^@ http://purl.uniprot.org/uniprot/C4PZQ3 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Mitochondrion|||This protein may be expected to contain an N-terminal transit peptide but none has been predicted. http://togogenome.org/gene/6183:Smp_043290 ^@ http://purl.uniprot.org/uniprot/C4Q8W8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6183:Smp_061570 ^@ http://purl.uniprot.org/uniprot/G4VKK2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 19 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/6183:Smp_012930 ^@ http://purl.uniprot.org/uniprot/G4V9I5 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/6183:Smp_053700 ^@ http://purl.uniprot.org/uniprot/G4VIZ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRQ/QCR8 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_021040 ^@ http://purl.uniprot.org/uniprot/G4VDL2 ^@ Similarity ^@ Belongs to the FAM32 family. http://togogenome.org/gene/6183:Smp_034980.1 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KEA9|||http://purl.uniprot.org/uniprot/G4V832 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_010900 ^@ http://purl.uniprot.org/uniprot/G4VMR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL53 family.|||Mitochondrion http://togogenome.org/gene/6183:Smp_061560 ^@ http://purl.uniprot.org/uniprot/G4VKK3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/6183:Smp_144570 ^@ http://purl.uniprot.org/uniprot/G4V7S8 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/6183:Smp_134790 ^@ http://purl.uniprot.org/uniprot/G4VFR3 ^@ Similarity|||Subunit ^@ Belongs to the TAF11 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6183:Smp_073290 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KHN6 ^@ Similarity ^@ Belongs to the PPP4R2 family. http://togogenome.org/gene/6183:Smp_157160 ^@ http://purl.uniprot.org/uniprot/G4VPU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP68 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.|||Cytoplasm|||nucleolus http://togogenome.org/gene/6183:Smp_042590.1 ^@ http://purl.uniprot.org/uniprot/G4VRD9 ^@ Similarity ^@ Belongs to the complex I 23 kDa subunit family. http://togogenome.org/gene/6183:Smp_103950 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KJY5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6183:Smp_024880 ^@ http://purl.uniprot.org/uniprot/G4VMA1 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. http://togogenome.org/gene/6183:Smp_048760.1 ^@ http://purl.uniprot.org/uniprot/G4VBY2 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/6183:Smp_046250 ^@ http://purl.uniprot.org/uniprot/G4VE02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/6183:Smp_055400 ^@ http://purl.uniprot.org/uniprot/G4V5V7 ^@ Similarity ^@ Belongs to the TBCB family. http://togogenome.org/gene/6183:Smp_022320.1 ^@ http://purl.uniprot.org/uniprot/A0A913JUH9|||http://purl.uniprot.org/uniprot/G4VPI1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_122920 ^@ http://purl.uniprot.org/uniprot/G4VCG2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_137590 ^@ http://purl.uniprot.org/uniprot/G4VP71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.|||Cytoplasm|||Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. http://togogenome.org/gene/6183:Smp_170290 ^@ http://purl.uniprot.org/uniprot/G4V8A2 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/6183:Smp_027400 ^@ http://purl.uniprot.org/uniprot/G4VHA4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/6183:Smp_019010 ^@ http://purl.uniprot.org/uniprot/G4VG40 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M49 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/6183:Smp_076040.1 ^@ http://purl.uniprot.org/uniprot/B8Y6H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/6183:Smp_060910 ^@ http://purl.uniprot.org/uniprot/G4VBP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/6183:Smp_030930.1 ^@ http://purl.uniprot.org/uniprot/G4VLU1|||http://purl.uniprot.org/uniprot/G4VLU2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the DPH1/DPH2 family. DPH1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. http://togogenome.org/gene/6183:Smp_146300 ^@ http://purl.uniprot.org/uniprot/G4VK93 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/6183:Smp_012970 ^@ http://purl.uniprot.org/uniprot/G4VEX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/6183:Smp_021300 ^@ http://purl.uniprot.org/uniprot/G4V8H8 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/6183:Smp_048660 ^@ http://purl.uniprot.org/uniprot/G4VSA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus http://togogenome.org/gene/6183:Smp_073590 ^@ http://purl.uniprot.org/uniprot/G4V709 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/6183:Smp_064240 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KGX2 ^@ Similarity ^@ Belongs to the adaptor complexes medium subunit family. http://togogenome.org/gene/6183:Smp_212320 ^@ http://purl.uniprot.org/uniprot/G4VLI9 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/6183:Smp_099030 ^@ http://purl.uniprot.org/uniprot/G4VR11 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6183:Smp_068270.1 ^@ http://purl.uniprot.org/uniprot/G4VTC5|||http://purl.uniprot.org/uniprot/G4VTC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/6183:Smp_021330.1 ^@ http://purl.uniprot.org/uniprot/G4V8H4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/6183:Smp_196480 ^@ http://purl.uniprot.org/uniprot/G4VAZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM15 family.|||Membrane http://togogenome.org/gene/6183:Smp_071880.1 ^@ http://purl.uniprot.org/uniprot/G4VCX9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_065290 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KH15 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6183:Smp_053800 ^@ http://purl.uniprot.org/uniprot/G4VHS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/6183:Smp_082370 ^@ http://purl.uniprot.org/uniprot/G4VN23 ^@ Similarity ^@ In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/6183:Smp_088600 ^@ http://purl.uniprot.org/uniprot/G4VDJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT2/3/5 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/6183:Smp_149350 ^@ http://purl.uniprot.org/uniprot/G4VMI6 ^@ Similarity ^@ Belongs to the Integrator subunit 12 family. http://togogenome.org/gene/6183:Smp_042090.1 ^@ http://purl.uniprot.org/uniprot/G4VJT2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL1 family. http://togogenome.org/gene/6183:Smp_003000 ^@ http://purl.uniprot.org/uniprot/G4VJ86 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6183:Smp_080920.1 ^@ http://purl.uniprot.org/uniprot/G4VTE1|||http://purl.uniprot.org/uniprot/G4VTE2|||http://purl.uniprot.org/uniprot/G4VTE3 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/6183:Smp_181290 ^@ http://purl.uniprot.org/uniprot/G4VER2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/6183:Smp_027480 ^@ http://purl.uniprot.org/uniprot/G4VIB9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA8 subunit family.|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/6183:Smp_091480 ^@ http://purl.uniprot.org/uniprot/G4V9L1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC25 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/6183:Smp_022960 ^@ http://purl.uniprot.org/uniprot/G4VN20 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/6183:Smp_207000 ^@ http://purl.uniprot.org/uniprot/C4PYP8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.|||Cytoplasm|||Mitochondrion intermembrane space|||Monomer.|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/6183:Smp_194770 ^@ http://purl.uniprot.org/uniprot/P16641 ^@ Developmental Stage|||Function|||Similarity ^@ Belongs to the ATP:guanido phosphotransferase family.|||Expressed at low levels in 37-day sporocysts, increases 25-fold in the infective cercarial and early schistosomular stages. Levels decrease dramatically in adults, adult males have approximately twice the expression level as in adult females.|||This family of enzymes reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). http://togogenome.org/gene/6183:Smp_064870 ^@ http://purl.uniprot.org/uniprot/G4VPU8 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/6183:Smp_069380 ^@ http://purl.uniprot.org/uniprot/G4V7N0 ^@ Similarity ^@ Belongs to the histone deacetylase family. HD type 2 subfamily. http://togogenome.org/gene/6183:Smp_050740 ^@ http://purl.uniprot.org/uniprot/G4VIA6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_103200 ^@ http://purl.uniprot.org/uniprot/G4VGY6 ^@ Similarity ^@ Belongs to the V-ATPase D subunit family. http://togogenome.org/gene/6183:Smp_053510.1 ^@ http://purl.uniprot.org/uniprot/G4VJ11 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. http://togogenome.org/gene/6183:Smp_087860 ^@ http://purl.uniprot.org/uniprot/G4VLR0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/6183:Smp_007660 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KC17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/6183:Smp_078640 ^@ http://purl.uniprot.org/uniprot/G4V9Z3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/6183:Smp_154270 ^@ http://purl.uniprot.org/uniprot/G4VMD4 ^@ Similarity ^@ In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family. http://togogenome.org/gene/6183:Smp_180140 ^@ http://purl.uniprot.org/uniprot/G4V6S5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6183:Smp_140550 ^@ http://purl.uniprot.org/uniprot/G4V9U0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bL35 family.|||Mitochondrion http://togogenome.org/gene/6183:Smp_032520.1 ^@ http://purl.uniprot.org/uniprot/G4VSF3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/6183:Smp_063560 ^@ http://purl.uniprot.org/uniprot/A0A5K4F4A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM120 family.|||Membrane http://togogenome.org/gene/6183:Smp_076660 ^@ http://purl.uniprot.org/uniprot/G4V7L5 ^@ Similarity ^@ Belongs to the DNA polymerase delta/II small subunit family. http://togogenome.org/gene/6183:Smp_016340 ^@ http://purl.uniprot.org/uniprot/G4VHF6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 8 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/6183:Smp_010690 ^@ http://purl.uniprot.org/uniprot/G4VMP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC2 family.|||Component of the Arp2/3 complex.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/6183:Smp_021320 ^@ http://purl.uniprot.org/uniprot/A0A5K4FCN2 ^@ Function ^@ May play an important role in spermatogenesis and/or testis development. http://togogenome.org/gene/6183:Smp_071380.2 ^@ http://purl.uniprot.org/uniprot/G4VFW7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_095190 ^@ http://purl.uniprot.org/uniprot/G4VRL9 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/6183:Smp_031070.1 ^@ http://purl.uniprot.org/uniprot/G4VPJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||microtubule organizing center http://togogenome.org/gene/6183:Smp_032790 ^@ http://purl.uniprot.org/uniprot/G4VDI1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMDT1/EMRE family.|||Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.|||Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_000740.1 ^@ http://purl.uniprot.org/uniprot/O17453|||http://purl.uniprot.org/uniprot/Q547D2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S5A family.|||Binds and presumably selects ubiquitin-conjugates for destruction.|||The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively (By similarity). http://togogenome.org/gene/6183:Smp_061920.1 ^@ http://purl.uniprot.org/uniprot/A9CBJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/6183:Smp_003300 ^@ http://purl.uniprot.org/uniprot/G4V6W4 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/6183:Smp_055990 ^@ http://purl.uniprot.org/uniprot/C4QCD2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). http://togogenome.org/gene/6183:Smp_036010 ^@ http://purl.uniprot.org/uniprot/G4VHT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/6183:Smp_045250 ^@ http://purl.uniprot.org/uniprot/G4VBS1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_129750 ^@ http://purl.uniprot.org/uniprot/G4VS29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/6183:Smp_025800 ^@ http://purl.uniprot.org/uniprot/G4VAQ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/6183:Smp_055050 ^@ http://purl.uniprot.org/uniprot/G4VH80 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/6183:Smp_016730 ^@ http://purl.uniprot.org/uniprot/G4VKX8 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/6183:Smp_174320 ^@ http://purl.uniprot.org/uniprot/G4VRL8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_043030 ^@ http://purl.uniprot.org/uniprot/Q26609 ^@ Function|||Similarity|||Subunit ^@ Belongs to the hexokinase family.|||Catalyzes the phosphorylation of various hexoses to hexose 6-phosphate.|||Monomer. http://togogenome.org/gene/6183:Smp_166980 ^@ http://purl.uniprot.org/uniprot/G4VC88 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TAF9 family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6183:Smp_067090 ^@ http://purl.uniprot.org/uniprot/G4V5C0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/6183:Smp_093750.1 ^@ http://purl.uniprot.org/uniprot/Q95W35 ^@ Similarity ^@ Belongs to the eIF-2-alpha family. http://togogenome.org/gene/6183:Smp_046600 ^@ http://purl.uniprot.org/uniprot/P53470 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.|||Belongs to the actin family.|||cytoskeleton http://togogenome.org/gene/6183:Smp_055340.1 ^@ http://purl.uniprot.org/uniprot/G4V5N2 ^@ Similarity ^@ Belongs to the lin-9 family. http://togogenome.org/gene/6183:Smp_103710 ^@ http://purl.uniprot.org/uniprot/G4VRA7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/6183:Smp_066890 ^@ http://purl.uniprot.org/uniprot/G4VIL3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS10 family. http://togogenome.org/gene/6183:Smp_146190 ^@ http://purl.uniprot.org/uniprot/G4VQS2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS21 family. http://togogenome.org/gene/6183:Smp_148160 ^@ http://purl.uniprot.org/uniprot/G4VSB1 ^@ Similarity ^@ Belongs to the SPATA6 family. http://togogenome.org/gene/6183:Smp_068250 ^@ http://purl.uniprot.org/uniprot/G4VTC3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.|||Binds 1 FAD per subunit.|||Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_207070 ^@ http://purl.uniprot.org/uniprot/G4VLZ9 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/6183:Smp_044750 ^@ http://purl.uniprot.org/uniprot/G4VK94 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_033020 ^@ http://purl.uniprot.org/uniprot/G4VR92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/6183:Smp_047110 ^@ http://purl.uniprot.org/uniprot/G4VN93 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/6183:Smp_048870 ^@ http://purl.uniprot.org/uniprot/G4VBZ2 ^@ Similarity ^@ Belongs to the CutA family. http://togogenome.org/gene/6183:Smp_094420 ^@ http://purl.uniprot.org/uniprot/G4VC25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/6183:Smp_058350 ^@ http://purl.uniprot.org/uniprot/G4VNL4 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/6183:Smp_047610 ^@ http://purl.uniprot.org/uniprot/G4VBH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC45 family.|||Nucleus http://togogenome.org/gene/6183:Smp_150160 ^@ http://purl.uniprot.org/uniprot/G4VI00 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX. http://togogenome.org/gene/6183:Smp_026190 ^@ http://purl.uniprot.org/uniprot/G4VJW9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP11 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/6183:Smp_048940 ^@ http://purl.uniprot.org/uniprot/G4VBZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Late endosome membrane http://togogenome.org/gene/6183:Smp_040970.1 ^@ http://purl.uniprot.org/uniprot/G4V7J8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/6183:Smp_049170 ^@ http://purl.uniprot.org/uniprot/G4VC17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. http://togogenome.org/gene/6183:Smp_001500 ^@ http://purl.uniprot.org/uniprot/G4VCF5 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/6183:Smp_136360 ^@ http://purl.uniprot.org/uniprot/G4VEY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/6183:Smp_044690 ^@ http://purl.uniprot.org/uniprot/G4VK90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/6183:Smp_033990 ^@ http://purl.uniprot.org/uniprot/G4V9T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.|||cytoskeleton http://togogenome.org/gene/6183:Smp_077400 ^@ http://purl.uniprot.org/uniprot/G4VTM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG3 family.|||Cytoplasm http://togogenome.org/gene/6183:Smp_069220.1 ^@ http://purl.uniprot.org/uniprot/G4VIP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESS2 family.|||Nucleus http://togogenome.org/gene/6183:Smp_044440 ^@ http://purl.uniprot.org/uniprot/G4VR32 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. http://togogenome.org/gene/6183:Smp_038340 ^@ http://purl.uniprot.org/uniprot/G4VNU4 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/6183:Smp_056370 ^@ http://purl.uniprot.org/uniprot/G4VSX8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the deoxyhypusine hydroxylase family.|||Binds 2 Fe(2+) ions per subunit.|||Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. http://togogenome.org/gene/6183:Smp_035470 ^@ http://purl.uniprot.org/uniprot/G4V7R9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DDOST 48 kDa subunit family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). http://togogenome.org/gene/6183:Smp_020080.1 ^@ http://purl.uniprot.org/uniprot/G4V8F7 ^@ Subunit ^@ G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. http://togogenome.org/gene/6183:Smp_036130 ^@ http://purl.uniprot.org/uniprot/G4VHU3 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/6183:Smp_031310 ^@ http://purl.uniprot.org/uniprot/G4VPM7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/6183:Smp_085010 ^@ http://purl.uniprot.org/uniprot/G4V5D3 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6183:Smp_210720 ^@ http://purl.uniprot.org/uniprot/G4VFA0 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/6183:Smp_132850.1 ^@ http://purl.uniprot.org/uniprot/G4VTW0 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/6183:Smp_036180 ^@ http://purl.uniprot.org/uniprot/G4V6E6 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/6183:Smp_025340 ^@ http://purl.uniprot.org/uniprot/G4VPE5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 10 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/6183:Smp_046550 ^@ http://purl.uniprot.org/uniprot/G4VLV8 ^@ Similarity ^@ Belongs to the bystin family. http://togogenome.org/gene/6183:Smp_059880 ^@ http://purl.uniprot.org/uniprot/G4VT24 ^@ Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. http://togogenome.org/gene/6183:Smp_072950 ^@ http://purl.uniprot.org/uniprot/G4V9Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/6183:Smp_072340 ^@ http://purl.uniprot.org/uniprot/G4V9B5 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/6183:Smp_089000.1 ^@ http://purl.uniprot.org/uniprot/G4VHM6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-delta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/6183:Smp_070760 ^@ http://purl.uniprot.org/uniprot/G4VEL9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_103610 ^@ http://purl.uniprot.org/uniprot/Q8MNY2 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6183:Smp_059540 ^@ http://purl.uniprot.org/uniprot/G4VKV4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).|||Cytoplasm|||Endoplasmic reticulum|||The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.|||The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER. http://togogenome.org/gene/6183:Smp_029700 ^@ http://purl.uniprot.org/uniprot/G4VFH1 ^@ Similarity ^@ Belongs to the NKAP family. http://togogenome.org/gene/6183:Smp_083200.1 ^@ http://purl.uniprot.org/uniprot/G4V7F4 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/6183:KEF69_p03 ^@ http://purl.uniprot.org/uniprot/Q9MD45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion membrane http://togogenome.org/gene/6183:Smp_180800 ^@ http://purl.uniprot.org/uniprot/G4V6G6 ^@ Similarity ^@ Belongs to the learning-associated protein family. http://togogenome.org/gene/6183:Smp_073720.1 ^@ http://purl.uniprot.org/uniprot/G4V6Z7 ^@ Function|||Similarity ^@ Belongs to the ARPC5 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. http://togogenome.org/gene/6183:Smp_089460.1 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KJ03 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/6183:Smp_045560 ^@ http://purl.uniprot.org/uniprot/G4VI62 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/6183:Smp_094880 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KJC9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. http://togogenome.org/gene/6183:Smp_007190 ^@ http://purl.uniprot.org/uniprot/G4VB14 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_008320 ^@ http://purl.uniprot.org/uniprot/G4V7H0 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/6183:Smp_104720 ^@ http://purl.uniprot.org/uniprot/C1M169 ^@ Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.|||Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. http://togogenome.org/gene/6183:Smp_144140 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KNS9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_016130 ^@ http://purl.uniprot.org/uniprot/G4V5G1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/6183:Smp_023360.1 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KDC5 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/6183:Smp_042560 ^@ http://purl.uniprot.org/uniprot/G4VRE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/6183:Smp_163110 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KRM8 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. DDX1 subfamily.|||RNA helicase.|||The helicase domain is involved in the stimulation of RELA transcriptional activity. http://togogenome.org/gene/6183:Smp_094760 ^@ http://purl.uniprot.org/uniprot/G4VTU1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6183:Smp_092490.1 ^@ http://purl.uniprot.org/uniprot/G4V5Q1 ^@ Similarity ^@ Belongs to the complex I 20 kDa subunit family. http://togogenome.org/gene/6183:Smp_088460 ^@ http://purl.uniprot.org/uniprot/G4V8A3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF alpha subunit family.|||Nucleus|||TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. http://togogenome.org/gene/6183:Smp_005790 ^@ http://purl.uniprot.org/uniprot/G4V734 ^@ Similarity|||Subunit ^@ Belongs to the G-alpha family. G(q) subfamily.|||G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. http://togogenome.org/gene/6183:Smp_006710 ^@ http://purl.uniprot.org/uniprot/G4V9V5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Nth/MutY family.|||Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.|||Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.|||Mitochondrion|||Nucleus http://togogenome.org/gene/6183:Smp_080980.1 ^@ http://purl.uniprot.org/uniprot/G4VTF1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_015720 ^@ http://purl.uniprot.org/uniprot/G4VSL7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.|||Cytoplasm|||Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.|||Monomer. http://togogenome.org/gene/6183:Smp_029820 ^@ http://purl.uniprot.org/uniprot/G4VFI4 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/6183:Smp_071560 ^@ http://purl.uniprot.org/uniprot/G4V9J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM147 family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6183:Smp_074510 ^@ http://purl.uniprot.org/uniprot/G4VRC1 ^@ Subunit ^@ G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. http://togogenome.org/gene/6183:Smp_022850.1 ^@ http://purl.uniprot.org/uniprot/G4VQ06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS31 family.|||Mitochondrion http://togogenome.org/gene/6183:Smp_073410 ^@ http://purl.uniprot.org/uniprot/G4VSW3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/6183:Smp_136240.1 ^@ http://purl.uniprot.org/uniprot/G4VKP4 ^@ Similarity ^@ Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. http://togogenome.org/gene/6183:Smp_146310 ^@ http://purl.uniprot.org/uniprot/G4VBJ7 ^@ Similarity ^@ Belongs to the exonuclease superfamily. TREX family. http://togogenome.org/gene/6183:Smp_036370 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KEG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/6183:Smp_005210 ^@ http://purl.uniprot.org/uniprot/G4V604 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Nucleus http://togogenome.org/gene/6183:Smp_090230 ^@ http://purl.uniprot.org/uniprot/G4VQW2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/6183:Smp_064040.1 ^@ http://purl.uniprot.org/uniprot/G4VIN1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6183:Smp_018480 ^@ http://purl.uniprot.org/uniprot/G4VGN4 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/6183:Smp_017890 ^@ http://purl.uniprot.org/uniprot/G4VNY2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_091010 ^@ http://purl.uniprot.org/uniprot/G4VRK1 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/6183:Smp_038680 ^@ http://purl.uniprot.org/uniprot/G4VI89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/6183:Smp_169050 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KSI6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_046100 ^@ http://purl.uniprot.org/uniprot/G4VPS8 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB4 subunit family.|||Complex I is composed of 45 different subunits. http://togogenome.org/gene/6183:Smp_045760 ^@ http://purl.uniprot.org/uniprot/G4VPP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM5 / TYW2 family.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Mitochondrion matrix|||Monomer.|||Nucleus|||Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. http://togogenome.org/gene/6183:Smp_071570 ^@ http://purl.uniprot.org/uniprot/G4V9J2 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/6183:Smp_052910 ^@ http://purl.uniprot.org/uniprot/G4VGF4 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/6183:Smp_003710 ^@ http://purl.uniprot.org/uniprot/G4VJX4 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/6183:Smp_075040 ^@ http://purl.uniprot.org/uniprot/G4VH08 ^@ Similarity ^@ Belongs to the UPF0538 family. http://togogenome.org/gene/6183:Smp_062900 ^@ http://purl.uniprot.org/uniprot/G4VHU6 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/6183:Smp_060820 ^@ http://purl.uniprot.org/uniprot/G4VBN6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.|||Binds 1 Mg(2+) ion per subunit.|||GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.|||Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.|||Mitochondrion http://togogenome.org/gene/6183:Smp_157680 ^@ http://purl.uniprot.org/uniprot/G4VPB2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/6183:Smp_079920 ^@ http://purl.uniprot.org/uniprot/G4VT40 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/6183:Smp_050940.1 ^@ http://purl.uniprot.org/uniprot/G4VMJ5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL5 family. http://togogenome.org/gene/6183:Smp_159520 ^@ http://purl.uniprot.org/uniprot/G4VQA4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6183:Smp_022400 ^@ http://purl.uniprot.org/uniprot/G4VPH5 ^@ Similarity ^@ Belongs to the GPI family. http://togogenome.org/gene/6183:Smp_152220 ^@ http://purl.uniprot.org/uniprot/G4V5X9 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/6183:Smp_070780 ^@ http://purl.uniprot.org/uniprot/G4VEM1 ^@ Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Homodimer. http://togogenome.org/gene/6183:Smp_134230 ^@ http://purl.uniprot.org/uniprot/G4VP93 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/6183:Smp_095480 ^@ http://purl.uniprot.org/uniprot/G4V849 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/6183:Smp_013060 ^@ http://purl.uniprot.org/uniprot/Q9GQN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/6183:Smp_039970 ^@ http://purl.uniprot.org/uniprot/G4VKG8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/6183:Smp_070030 ^@ http://purl.uniprot.org/uniprot/G4VJC7 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/6183:Smp_201760 ^@ http://purl.uniprot.org/uniprot/G4VBT9 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/6183:Smp_087340 ^@ http://purl.uniprot.org/uniprot/G4VJF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GLE1 family.|||Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/6183:Smp_046290 ^@ http://purl.uniprot.org/uniprot/G4VKT0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_101970 ^@ http://purl.uniprot.org/uniprot/G4VTB5 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/6183:Smp_038950 ^@ http://purl.uniprot.org/uniprot/G4VQZ5 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/6183:Smp_085110.1 ^@ http://purl.uniprot.org/uniprot/G4VES1 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/6183:Smp_077790 ^@ http://purl.uniprot.org/uniprot/G4VL73 ^@ Similarity|||Subunit ^@ Belongs to the histone H2B family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6183:Smp_082750 ^@ http://purl.uniprot.org/uniprot/G4VC84 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6183:Smp_001640 ^@ http://purl.uniprot.org/uniprot/G4VCG8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/6183:Smp_012280 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KCD9 ^@ Similarity ^@ Belongs to the CDV3 family. http://togogenome.org/gene/6183:Smp_049630 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KFN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ING family.|||Nucleus http://togogenome.org/gene/6183:KEF69_p11 ^@ http://purl.uniprot.org/uniprot/Q9MD49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Membrane http://togogenome.org/gene/6183:Smp_009030 ^@ http://purl.uniprot.org/uniprot/G4VIG3 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/6183:Smp_016250.1 ^@ http://purl.uniprot.org/uniprot/G4VHF0 ^@ Subunit ^@ G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. http://togogenome.org/gene/6183:Smp_060180 ^@ http://purl.uniprot.org/uniprot/G4VQM9 ^@ Similarity ^@ Belongs to the WD repeat SEC13 family. http://togogenome.org/gene/6183:Smp_169340 ^@ http://purl.uniprot.org/uniprot/G4VKL7 ^@ Similarity ^@ Belongs to the MIX23 family. http://togogenome.org/gene/6183:Smp_194170 ^@ http://purl.uniprot.org/uniprot/G4V672 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_052760 ^@ http://purl.uniprot.org/uniprot/G4VM34 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex.|||In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.|||Nucleus http://togogenome.org/gene/6183:Smp_024520 ^@ http://purl.uniprot.org/uniprot/G4VC26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/6183:Smp_126370 ^@ http://purl.uniprot.org/uniprot/G4VPW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/6183:Smp_005000 ^@ http://purl.uniprot.org/uniprot/G4V5L5 ^@ Similarity ^@ Belongs to the NECAP family. http://togogenome.org/gene/6183:Smp_016780 ^@ http://purl.uniprot.org/uniprot/G4VKY4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/6183:Smp_049270 ^@ http://purl.uniprot.org/uniprot/G4V8X9 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/6183:Smp_027240 ^@ http://purl.uniprot.org/uniprot/G4VHC3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS18 family. http://togogenome.org/gene/6183:Smp_004940 ^@ http://purl.uniprot.org/uniprot/G4V5M1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/6183:Smp_038240 ^@ http://purl.uniprot.org/uniprot/G4VNT2 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Monomer. http://togogenome.org/gene/6183:Smp_098330 ^@ http://purl.uniprot.org/uniprot/G4V8R9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL8 family. http://togogenome.org/gene/6183:Smp_032800.1 ^@ http://purl.uniprot.org/uniprot/G4VDI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SMU1 family.|||Nucleus speckle http://togogenome.org/gene/6183:Smp_074930 ^@ http://purl.uniprot.org/uniprot/G4VH15 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/6183:Smp_038700.1 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KEP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNF10 family.|||Cytoplasm http://togogenome.org/gene/6183:Smp_094480 ^@ http://purl.uniprot.org/uniprot/G4VTR5 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/6183:Smp_028690 ^@ http://purl.uniprot.org/uniprot/Q8MZK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/6183:Smp_001170 ^@ http://purl.uniprot.org/uniprot/G4V5Q4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit A family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. http://togogenome.org/gene/6183:Smp_123840 ^@ http://purl.uniprot.org/uniprot/G4V6X4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6183:Smp_031730 ^@ http://purl.uniprot.org/uniprot/G4VN62 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6183:Smp_105410 ^@ http://purl.uniprot.org/uniprot/G4VC44 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/6183:Smp_024360.1 ^@ http://purl.uniprot.org/uniprot/G4VQ87 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM50 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_012530.1 ^@ http://purl.uniprot.org/uniprot/Q15ER1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT4 family.|||Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.|||Nucleus http://togogenome.org/gene/6183:Smp_118040 ^@ http://purl.uniprot.org/uniprot/G4V636 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6183:Smp_143740 ^@ http://purl.uniprot.org/uniprot/G4VSS2 ^@ Similarity|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Homodimer. http://togogenome.org/gene/6183:Smp_054340.1 ^@ http://purl.uniprot.org/uniprot/G4VQK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/6183:Smp_013460 ^@ http://purl.uniprot.org/uniprot/G4VH48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/6183:Smp_063640 ^@ http://purl.uniprot.org/uniprot/G4VA12 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/6183:Smp_086830 ^@ http://purl.uniprot.org/uniprot/G4V8L7 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/6183:Smp_175210 ^@ http://purl.uniprot.org/uniprot/G4VJD9 ^@ Function|||Similarity ^@ Belongs to the E(R) family.|||May have a role in the cell cycle. http://togogenome.org/gene/6183:Smp_005880 ^@ http://purl.uniprot.org/uniprot/G4V721 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. http://togogenome.org/gene/6183:Smp_126310 ^@ http://purl.uniprot.org/uniprot/G4VPX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||cytoskeleton http://togogenome.org/gene/6183:Smp_166420 ^@ http://purl.uniprot.org/uniprot/G4VDR5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TTC30/dfy-1/fleer family.|||Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.|||cilium http://togogenome.org/gene/6183:Smp_068580.1 ^@ http://purl.uniprot.org/uniprot/G4VDP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6183:Smp_074150.1 ^@ http://purl.uniprot.org/uniprot/C4QH88 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/6183:Smp_062420.1 ^@ http://purl.uniprot.org/uniprot/G4VJJ1 ^@ Similarity ^@ Belongs to the FAM10 family. http://togogenome.org/gene/6183:Smp_115340 ^@ http://purl.uniprot.org/uniprot/G4VG91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA40 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/6183:Smp_074230 ^@ http://purl.uniprot.org/uniprot/G4VLA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/6183:Smp_053820 ^@ http://purl.uniprot.org/uniprot/G4VHS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Membrane http://togogenome.org/gene/6183:Smp_074390 ^@ http://purl.uniprot.org/uniprot/G4VLC5 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/6183:Smp_082620 ^@ http://purl.uniprot.org/uniprot/G4VC95 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48A family.|||Binds 1 zinc ion per subunit.|||Endoplasmic reticulum membrane|||Proteolytically removes the C-terminal three residues of farnesylated proteins. http://togogenome.org/gene/6183:Smp_058970 ^@ http://purl.uniprot.org/uniprot/G4VJ24 ^@ Similarity ^@ Belongs to the SDHAF4 family. http://togogenome.org/gene/6183:Smp_099420 ^@ http://purl.uniprot.org/uniprot/G4VLQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_104000.1 ^@ http://purl.uniprot.org/uniprot/G4VAT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM18 family.|||Membrane http://togogenome.org/gene/6183:Smp_026160.1 ^@ http://purl.uniprot.org/uniprot/G4VKQ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_099870 ^@ http://purl.uniprot.org/uniprot/G4VAD2 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/6183:Smp_007960 ^@ http://purl.uniprot.org/uniprot/G4VJ60 ^@ Similarity ^@ Belongs to the 4HPPD family. http://togogenome.org/gene/6183:Smp_064350 ^@ http://purl.uniprot.org/uniprot/G4VKD1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits. http://togogenome.org/gene/6183:Smp_002010 ^@ http://purl.uniprot.org/uniprot/G4VLH6 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. http://togogenome.org/gene/6183:Smp_145360.1 ^@ http://purl.uniprot.org/uniprot/G4VIU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIEAP family.|||Cytoplasm|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/6183:Smp_083120 ^@ http://purl.uniprot.org/uniprot/G4V7E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_129110.1 ^@ http://purl.uniprot.org/uniprot/G4VEX0|||http://purl.uniprot.org/uniprot/G4VEX1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAN1 family.|||Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.|||Nucleus http://togogenome.org/gene/6183:Smp_088650 ^@ http://purl.uniprot.org/uniprot/G4VDJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/6183:Smp_028990.1 ^@ http://purl.uniprot.org/uniprot/G4VGS4 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/6183:Smp_053550.1 ^@ http://purl.uniprot.org/uniprot/G4VJ07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2H phosphoesterase superfamily. USB1 family.|||Nucleus|||Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA. http://togogenome.org/gene/6183:Smp_147370 ^@ http://purl.uniprot.org/uniprot/G4VNB1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_058150.1 ^@ http://purl.uniprot.org/uniprot/G4VK46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I NDUFB10 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_100110 ^@ http://purl.uniprot.org/uniprot/G4VG80 ^@ Similarity ^@ Belongs to the DPH3 family. http://togogenome.org/gene/6183:Smp_010400 ^@ http://purl.uniprot.org/uniprot/G4VML9 ^@ Function|||Similarity ^@ Belongs to the MGR2 family.|||Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.|||Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation. http://togogenome.org/gene/6183:Smp_080730 ^@ http://purl.uniprot.org/uniprot/G4VLX9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6183:Smp_027220 ^@ http://purl.uniprot.org/uniprot/G4VHC5 ^@ Similarity ^@ Belongs to the OPI10 family. http://togogenome.org/gene/6183:Smp_046630 ^@ http://purl.uniprot.org/uniprot/G4VLW5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/6183:Smp_090920.1 ^@ http://purl.uniprot.org/uniprot/G4V8K8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/6183:Smp_046020 ^@ http://purl.uniprot.org/uniprot/G4VPR7 ^@ Similarity ^@ Belongs to the SDS22 family. http://togogenome.org/gene/6183:Smp_168520 ^@ http://purl.uniprot.org/uniprot/G4VI74 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/6183:Smp_008120 ^@ http://purl.uniprot.org/uniprot/G4V7I9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 6 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/6183:Smp_020220.1 ^@ http://purl.uniprot.org/uniprot/G4V8D5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes small subunit family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. http://togogenome.org/gene/6183:Smp_063300 ^@ http://purl.uniprot.org/uniprot/Q15ET2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/6183:Smp_169690 ^@ http://purl.uniprot.org/uniprot/G4VG55 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPE family.|||Cytoplasm|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/6183:Smp_009390.1 ^@ http://purl.uniprot.org/uniprot/G4VL14 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/6183:Smp_051070 ^@ http://purl.uniprot.org/uniprot/G4VKR4 ^@ Similarity ^@ Belongs to the gonadal family. http://togogenome.org/gene/6183:Smp_076030.1 ^@ http://purl.uniprot.org/uniprot/G4VSU0 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/6183:Smp_008220 ^@ http://purl.uniprot.org/uniprot/G4V7H9 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/6183:Smp_069240 ^@ http://purl.uniprot.org/uniprot/Q26597 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_029740 ^@ http://purl.uniprot.org/uniprot/G4VFH6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SDHAF2 family.|||Interacts with the flavoprotein subunit within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer. http://togogenome.org/gene/6183:Smp_102510 ^@ http://purl.uniprot.org/uniprot/G4VJX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/6183:Smp_027010.1 ^@ http://purl.uniprot.org/uniprot/G4VFZ8 ^@ Similarity ^@ Belongs to the adaptor complexes medium subunit family. http://togogenome.org/gene/6183:Smp_021760 ^@ http://purl.uniprot.org/uniprot/G4VDU6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NIP7 family.|||Interacts with pre-ribosome complex.|||Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.|||nucleolus http://togogenome.org/gene/6183:Smp_044550.1 ^@ http://purl.uniprot.org/uniprot/G4VQS9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_009550 ^@ http://purl.uniprot.org/uniprot/G4V9Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||Nucleus http://togogenome.org/gene/6183:Smp_098840 ^@ http://purl.uniprot.org/uniprot/G4V683 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily.|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/6183:Smp_085750 ^@ http://purl.uniprot.org/uniprot/G4VF33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOA36 family.|||nucleolus http://togogenome.org/gene/6183:Smp_031770.1 ^@ http://purl.uniprot.org/uniprot/G4VN65|||http://purl.uniprot.org/uniprot/G4VN73|||http://purl.uniprot.org/uniprot/G4VN74|||http://purl.uniprot.org/uniprot/G4VN76|||http://purl.uniprot.org/uniprot/G4VN78|||http://purl.uniprot.org/uniprot/P42638 ^@ Domain|||Function|||Similarity|||Subunit|||Tissue Specificity ^@ Associated with the protective tegument surrounding the sporocyst.|||Belongs to the tropomyosin family.|||Homodimer.|||The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.|||Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. http://togogenome.org/gene/6183:Smp_022570.1 ^@ http://purl.uniprot.org/uniprot/G4VEB2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SGF11 family.|||Component of some SAGA transcription coactivator-HAT complexes.|||Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.|||Nucleus http://togogenome.org/gene/6183:Smp_134510 ^@ http://purl.uniprot.org/uniprot/G4VN13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase inhibitor family.|||Mitochondrion http://togogenome.org/gene/6183:Smp_129500 ^@ http://purl.uniprot.org/uniprot/G4VH38 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/6183:Smp_053560 ^@ http://purl.uniprot.org/uniprot/G4VJ06 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6183:Smp_078730 ^@ http://purl.uniprot.org/uniprot/G4VFD7 ^@ Similarity ^@ Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. http://togogenome.org/gene/6183:Smp_141290.1 ^@ http://purl.uniprot.org/uniprot/G4V7R2|||http://purl.uniprot.org/uniprot/G4V7R3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Structural component of the gap junctions.|||gap junction http://togogenome.org/gene/6183:Smp_123040 ^@ http://purl.uniprot.org/uniprot/G4VCI2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_038980.1 ^@ http://purl.uniprot.org/uniprot/G4VQZ3 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/6183:Smp_044250 ^@ http://purl.uniprot.org/uniprot/G4VEI6 ^@ Similarity ^@ Belongs to the peptidase M67C family. http://togogenome.org/gene/6183:Smp_017230 ^@ http://purl.uniprot.org/uniprot/G4VE80 ^@ Similarity ^@ Belongs to the NAPRTase family. http://togogenome.org/gene/6183:Smp_042400 ^@ http://purl.uniprot.org/uniprot/G4VJE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARMET family.|||Secreted http://togogenome.org/gene/6183:Smp_041980 ^@ http://purl.uniprot.org/uniprot/G4VJS1 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/6183:Smp_095000.1 ^@ http://purl.uniprot.org/uniprot/A0A5K4FD47 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/6183:Smp_179130 ^@ http://purl.uniprot.org/uniprot/G4VJX3 ^@ Similarity ^@ Belongs to the SMIM12 family. http://togogenome.org/gene/6183:Smp_028060 ^@ http://purl.uniprot.org/uniprot/G4V631 ^@ Similarity ^@ Belongs to the SURF6 family. http://togogenome.org/gene/6183:Smp_124240 ^@ http://purl.uniprot.org/uniprot/C4PY08 ^@ Similarity ^@ Belongs to the X(+)/potassium ATPases subunit beta family. http://togogenome.org/gene/6183:Smp_051080 ^@ http://purl.uniprot.org/uniprot/G4VKR5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/6183:Smp_105330 ^@ http://purl.uniprot.org/uniprot/G4V5D9 ^@ Function ^@ Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. http://togogenome.org/gene/6183:Smp_147820 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KPD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COA8 family.|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_084620 ^@ http://purl.uniprot.org/uniprot/G4V6D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcriptional coactivator PC4 family.|||Nucleus http://togogenome.org/gene/6183:Smp_002840 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KBK4 ^@ Similarity ^@ Belongs to the UPF0489 family. http://togogenome.org/gene/6183:Smp_073680.1 ^@ http://purl.uniprot.org/uniprot/G4V701 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/6183:Smp_129760 ^@ http://purl.uniprot.org/uniprot/G4VS32 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. http://togogenome.org/gene/6183:Smp_071140 ^@ http://purl.uniprot.org/uniprot/G4V7X9 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/6183:Smp_021750.1 ^@ http://purl.uniprot.org/uniprot/G4VDU5 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/6183:Smp_054470 ^@ http://purl.uniprot.org/uniprot/Q6B963 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/6183:Smp_026300 ^@ http://purl.uniprot.org/uniprot/G4VEY5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with 90S and pre-40S pre-ribosomal particles.|||Belongs to the RRP36 family.|||Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.|||nucleolus http://togogenome.org/gene/6183:Smp_013520 ^@ http://purl.uniprot.org/uniprot/G4VH39 ^@ Similarity ^@ Belongs to the NCBP3 family. http://togogenome.org/gene/6183:Smp_127940 ^@ http://purl.uniprot.org/uniprot/G4VMR3 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/6183:Smp_096910 ^@ http://purl.uniprot.org/uniprot/G4VBL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6183:Smp_150540 ^@ http://purl.uniprot.org/uniprot/G4VK04 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6183:Smp_073070 ^@ http://purl.uniprot.org/uniprot/G4VA64 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/6183:Smp_140510 ^@ http://purl.uniprot.org/uniprot/G4V9S9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_052280.1 ^@ http://purl.uniprot.org/uniprot/G4VHZ6 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/6183:Smp_159140 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KR35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Membrane http://togogenome.org/gene/6183:Smp_045610 ^@ http://purl.uniprot.org/uniprot/G4VK76 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/6183:Smp_092850.1 ^@ http://purl.uniprot.org/uniprot/G4V6G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Spartan family.|||Chromosome|||Nucleus http://togogenome.org/gene/6183:Smp_028070.1 ^@ http://purl.uniprot.org/uniprot/G4V630 ^@ Similarity ^@ Belongs to the BicD family. http://togogenome.org/gene/6183:Smp_068280 ^@ http://purl.uniprot.org/uniprot/G4VTC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/6183:Smp_210290 ^@ http://purl.uniprot.org/uniprot/G4VJK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Membrane http://togogenome.org/gene/6183:Smp_082430 ^@ http://purl.uniprot.org/uniprot/G4VGI0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:26898674). The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (Probable).|||Homodimer. http://togogenome.org/gene/6183:Smp_064510 ^@ http://purl.uniprot.org/uniprot/G4VKB6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOB1 family.|||May play a role in mRNA degradation.|||Nucleus http://togogenome.org/gene/6183:Smp_210450 ^@ http://purl.uniprot.org/uniprot/G4VB00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS29 family.|||Mitochondrion http://togogenome.org/gene/6183:Smp_048230 ^@ http://purl.uniprot.org/uniprot/G4V8W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Late endosome membrane|||Membrane http://togogenome.org/gene/6183:Smp_005720 ^@ http://purl.uniprot.org/uniprot/G4V740 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/6183:Smp_076650.1 ^@ http://purl.uniprot.org/uniprot/G4VF36|||http://purl.uniprot.org/uniprot/G4VF37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Orai family.|||Membrane http://togogenome.org/gene/6183:Smp_003440 ^@ http://purl.uniprot.org/uniprot/G4V6P0 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/6183:Smp_040510 ^@ http://purl.uniprot.org/uniprot/G4VB58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 18 family.|||Golgi apparatus membrane|||Membrane|||Secreted http://togogenome.org/gene/6183:Smp_131450 ^@ http://purl.uniprot.org/uniprot/G4VTK8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS3 family. http://togogenome.org/gene/6183:Smp_096750 ^@ http://purl.uniprot.org/uniprot/G4VJD7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/6183:Smp_104960 ^@ http://purl.uniprot.org/uniprot/G4VJV9 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/6183:Smp_025160.1 ^@ http://purl.uniprot.org/uniprot/G4VPG3|||http://purl.uniprot.org/uniprot/O18501 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/6183:Smp_040020 ^@ http://purl.uniprot.org/uniprot/G4VKH6 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6183:Smp_125780 ^@ http://purl.uniprot.org/uniprot/G4V9W8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphatidyl serine synthase family.|||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6183:Smp_047650 ^@ http://purl.uniprot.org/uniprot/G4VBG6 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/6183:Smp_016870 ^@ http://purl.uniprot.org/uniprot/G4VKZ6 ^@ Similarity ^@ Belongs to the MAP65/ASE1 family. http://togogenome.org/gene/6183:Smp_148560.1 ^@ http://purl.uniprot.org/uniprot/G4V8Y8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAM41 family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_011230 ^@ http://purl.uniprot.org/uniprot/G4VD88 ^@ Similarity ^@ Belongs to the peptidase C13 family. http://togogenome.org/gene/6183:Smp_035030 ^@ http://purl.uniprot.org/uniprot/G4V825 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. http://togogenome.org/gene/6183:Smp_074260 ^@ http://purl.uniprot.org/uniprot/G4VLB2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.|||Belongs to the mitochondrion-specific ribosomal protein mL64 family.|||Mitochondrion|||Nucleus http://togogenome.org/gene/6183:Smp_093280 ^@ http://purl.uniprot.org/uniprot/A5H659 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Nucleus http://togogenome.org/gene/6183:Smp_079710 ^@ http://purl.uniprot.org/uniprot/G4VFB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA2 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_171720 ^@ http://purl.uniprot.org/uniprot/G4VJ83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/6183:Smp_012860 ^@ http://purl.uniprot.org/uniprot/G4V9H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRM6/GCD10 family.|||Nucleus http://togogenome.org/gene/6183:Smp_053300 ^@ http://purl.uniprot.org/uniprot/C4QBN1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6183:Smp_042550 ^@ http://purl.uniprot.org/uniprot/G4VRE2 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/6183:Smp_075560 ^@ http://purl.uniprot.org/uniprot/G4VT90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/6183:Smp_019060 ^@ http://purl.uniprot.org/uniprot/G4VG47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Endoplasmic reticulum membrane|||Membrane|||Necessary for protein translocation in the endoplasmic reticulum. http://togogenome.org/gene/6183:Smp_013690 ^@ http://purl.uniprot.org/uniprot/G4V6A5 ^@ Similarity ^@ Belongs to the BROX family. http://togogenome.org/gene/6183:Smp_045510 ^@ http://purl.uniprot.org/uniprot/Q2VU48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/6183:Smp_004070 ^@ http://purl.uniprot.org/uniprot/G4V6B2 ^@ Function|||Similarity ^@ Belongs to the beta-class carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/6183:Smp_140180 ^@ http://purl.uniprot.org/uniprot/G4VMT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/6183:Smp_025510 ^@ http://purl.uniprot.org/uniprot/G4VPD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Endosome membrane|||Membrane http://togogenome.org/gene/6183:Smp_012570 ^@ http://purl.uniprot.org/uniprot/G4V978 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/6183:Smp_196790 ^@ http://purl.uniprot.org/uniprot/Q6BC92 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit.|||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. http://togogenome.org/gene/6183:Smp_035020.1 ^@ http://purl.uniprot.org/uniprot/G4V827 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_029040 ^@ http://purl.uniprot.org/uniprot/G4VGT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-50 family.|||Membrane http://togogenome.org/gene/6183:Smp_126520 ^@ http://purl.uniprot.org/uniprot/G4VN39 ^@ Similarity ^@ Belongs to the STAM family. http://togogenome.org/gene/6183:Smp_210750 ^@ http://purl.uniprot.org/uniprot/G4V8N4 ^@ Similarity ^@ Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily. http://togogenome.org/gene/6183:Smp_039980 ^@ http://purl.uniprot.org/uniprot/G4VKH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS33 family.|||Mitochondrion http://togogenome.org/gene/6183:Smp_133860 ^@ http://purl.uniprot.org/uniprot/G4VNG8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 18 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/6183:Smp_022640 ^@ http://purl.uniprot.org/uniprot/G4V5V3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/6183:Smp_003140.1 ^@ http://purl.uniprot.org/uniprot/G4V6X9 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/6183:Smp_126110 ^@ http://purl.uniprot.org/uniprot/G4VB10 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.|||Cytoplasm|||centrosome|||spindle|||spindle pole http://togogenome.org/gene/6183:Smp_066990 ^@ http://purl.uniprot.org/uniprot/Q15EU0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS10 family. http://togogenome.org/gene/6183:Smp_029890 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KDV9 ^@ Cofactor|||Developmental Stage|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||C-terminus (307-412) is necessary for binding to liposomal membranes as assessed by phosphatidylinositol-4,5-bisphosphate (PIP2)-containing giant unilamellar vesicles (GUVs), models of biological membranes.|||Expressed throughout the developmental cycle of the schistosome, with the highest expression in 14-day old schistosomula. Expressed in superficial structures of the miracidia and sporocysts, with high expression in ciliated epidermal plates of the miracidium, and in the longitudinal and circular muscles of the sporocyst. High expression also in the optical sections of germ cells in miracidia and 2-day old sporocysts. Expressed along the protonephridial ducts of the cercaria, extending laterally nearly the whole length on both sides of the larva. More specifically expressed at the collecting tubules of this osmoregulatory system. Expressed ubiquitously in the schistosomulum. In adults, expression is higher in males than in females.|||Filament-forming GTP-binding protein. Lacks GTPase activity, which is likely due to absence of an essential threonine residue important for hydrolytic activity in septins. May be involved in membrane remodeling, potentially by its nucleotide-dependent cellular membrane association/dissociation ability (PubMed:24464615). Able to bind to phosphatidylinositol-4,5-bisphosphate (PIP2)-containing giant unilamellar vesicles (GUVs), which serve as a model of biological membranes. Self-assembles into ordered cage-like structures on the vesicle membrane. Binds also to 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS)-containing vesicles suggesting the requirement for negatively charged membranes. Is also able to promote deformation of the GUVs (PubMed:27687162).|||Mg(2+) is essential for the GTP-binding, but GDP-binding does not require a metal cofactor.|||Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules (By similarity). Homodimer (PubMed:27687162, PubMed:24464615). Homooligomerizes (PubMed:27687162). Forms (via GTP-binding domain) heterodimers with SEPT5 (via GTP-binding domain) in a nucleotide-dependent manner with GTP promoting heterodimerization most efficiently (PubMed:27687162). Component of the filamentous forming heterocomplex composed of SEPT10, SEPT5 and SEPT7.2 (PubMed:24768753, PubMed:27687162). Heterocomplex formation and the filamentous polymerization of the complexes is enhanced by forchlorfenuron (FCF), a synthetic phenylurea cytokinin (PubMed:24768753). The heterocomplex is able to bind on the membranes of the phosphatidylinositol-4,5-bisphosphate (PIP2)-containing giant unilamellar vesicles (GUVs), which serve as a model of biological membranes (PubMed:27687162).|||cytoskeleton http://togogenome.org/gene/6183:Smp_161820 ^@ http://purl.uniprot.org/uniprot/G4VA83 ^@ Subcellular Location Annotation ^@ Nucleus|||kinetochore http://togogenome.org/gene/6183:Smp_096780.1 ^@ http://purl.uniprot.org/uniprot/G4VJD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GDT1 family.|||Membrane http://togogenome.org/gene/6183:Smp_074070.1 ^@ http://purl.uniprot.org/uniprot/G4VGJ3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_153890.1 ^@ http://purl.uniprot.org/uniprot/G4VJ18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP2 family.|||Membrane http://togogenome.org/gene/6183:Smp_046930 ^@ http://purl.uniprot.org/uniprot/G4VCM2 ^@ Similarity ^@ Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily. http://togogenome.org/gene/6183:Smp_143780 ^@ http://purl.uniprot.org/uniprot/G4VSR3 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/6183:Smp_079960 ^@ http://purl.uniprot.org/uniprot/G4VTA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/6183:Smp_123000.1 ^@ http://purl.uniprot.org/uniprot/G4VCH5 ^@ Similarity ^@ Belongs to the SKI family. http://togogenome.org/gene/6183:Smp_060070 ^@ http://purl.uniprot.org/uniprot/G4VAK1 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/6183:Smp_186710 ^@ http://purl.uniprot.org/uniprot/G4VLD8 ^@ Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer. http://togogenome.org/gene/6183:Smp_133110 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KM52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||Nucleus|||Required for pre-mRNA splicing. http://togogenome.org/gene/6183:Smp_092780.1 ^@ http://purl.uniprot.org/uniprot/G4V6J1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAPC3/SRD2 family.|||Nucleus|||Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.|||Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. http://togogenome.org/gene/6183:Smp_004080 ^@ http://purl.uniprot.org/uniprot/G4V6B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/6183:Smp_093690.1 ^@ http://purl.uniprot.org/uniprot/G4V9R1 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/6183:Smp_002880.1 ^@ http://purl.uniprot.org/uniprot/G4VLJ0 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/6183:Smp_042050 ^@ http://purl.uniprot.org/uniprot/G4VJS6 ^@ Similarity ^@ Belongs to the CWF19 family. http://togogenome.org/gene/6183:Smp_044020 ^@ http://purl.uniprot.org/uniprot/G4VD35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/6183:Smp_106050 ^@ http://purl.uniprot.org/uniprot/G4VEN8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/6183:Smp_019990 ^@ http://purl.uniprot.org/uniprot/G4V8G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Golgi apparatus|||clathrin-coated pit http://togogenome.org/gene/6183:Smp_043150 ^@ http://purl.uniprot.org/uniprot/Q04702 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/6183:Smp_056620 ^@ http://purl.uniprot.org/uniprot/G4VH55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RecQ subfamily.|||Nucleus http://togogenome.org/gene/6183:Smp_079560 ^@ http://purl.uniprot.org/uniprot/G4V7V1 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/6183:Smp_064500 ^@ http://purl.uniprot.org/uniprot/G4VKB7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYF2 family.|||Involved in pre-mRNA splicing.|||May be part of a spliceosome complex.|||Nucleus http://togogenome.org/gene/6183:Smp_051010 ^@ http://purl.uniprot.org/uniprot/G4VKQ8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/6183:Smp_064020.2 ^@ http://purl.uniprot.org/uniprot/G4VIN5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/6183:Smp_128610 ^@ http://purl.uniprot.org/uniprot/G4VS06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase IV family.|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_002920.1 ^@ http://purl.uniprot.org/uniprot/G4VLI4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_024140.1 ^@ http://purl.uniprot.org/uniprot/G4VQ61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/6183:Smp_050880 ^@ http://purl.uniprot.org/uniprot/G4VMI8 ^@ Similarity ^@ Belongs to the UPF0587 family. http://togogenome.org/gene/6183:Smp_041760 ^@ http://purl.uniprot.org/uniprot/G4VJQ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_084830 ^@ http://purl.uniprot.org/uniprot/G4VFD1 ^@ Function|||Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.|||Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. http://togogenome.org/gene/6183:Smp_027300 ^@ http://purl.uniprot.org/uniprot/G4VHB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.|||Nucleus|||centromere http://togogenome.org/gene/6183:Smp_059670 ^@ http://purl.uniprot.org/uniprot/G4VMD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/6183:Smp_094020 ^@ http://purl.uniprot.org/uniprot/G4V5G3 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/6183:Smp_163850 ^@ http://purl.uniprot.org/uniprot/G4VTL9 ^@ Similarity ^@ Belongs to the TIP41 family. http://togogenome.org/gene/6183:Smp_091360 ^@ http://purl.uniprot.org/uniprot/G4V9D4 ^@ Similarity ^@ Belongs to the pym family. http://togogenome.org/gene/6183:Smp_173480 ^@ http://purl.uniprot.org/uniprot/G4V9Q9 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/6183:Smp_036220 ^@ http://purl.uniprot.org/uniprot/G4V6E9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6183:Smp_007380 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KC02 ^@ Similarity ^@ Belongs to the STEEP1 family. http://togogenome.org/gene/6183:Smp_075220.1 ^@ http://purl.uniprot.org/uniprot/G4VS61 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/6183:Smp_056970.1 ^@ http://purl.uniprot.org/uniprot/G4V5I4|||http://purl.uniprot.org/uniprot/P20287 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer.|||This antigen is associated with human resistance to schistosomiasis. http://togogenome.org/gene/6183:Smp_049330 ^@ http://purl.uniprot.org/uniprot/G4V8Y9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_002930 ^@ http://purl.uniprot.org/uniprot/G4VFE8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6183:Smp_165950 ^@ http://purl.uniprot.org/uniprot/G4V8P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||flagellum http://togogenome.org/gene/6183:Smp_001830.1 ^@ http://purl.uniprot.org/uniprot/G4VLF7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/6183:Smp_198020 ^@ http://purl.uniprot.org/uniprot/G4VHP5 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/6183:Smp_203170 ^@ http://purl.uniprot.org/uniprot/G4VMC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6183:Smp_080100 ^@ http://purl.uniprot.org/uniprot/G4VJM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/6183:Smp_007900.1 ^@ http://purl.uniprot.org/uniprot/G4V5P5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/6183:Smp_065160 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KGZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the taffazin family.|||Mitochondrion inner membrane|||Mitochondrion outer membrane http://togogenome.org/gene/6183:Smp_180060 ^@ http://purl.uniprot.org/uniprot/G4VRU9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ7 family.|||Binds 2 iron ions per subunit.|||Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.|||Component of a multi-subunit COQ enzyme complex.|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_194700 ^@ http://purl.uniprot.org/uniprot/G4VGD7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_057020 ^@ http://purl.uniprot.org/uniprot/G4V5I9 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/6183:Smp_049140 ^@ http://purl.uniprot.org/uniprot/G4VC14 ^@ Domain|||Function|||Similarity ^@ Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.|||Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.|||Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine. http://togogenome.org/gene/6183:Smp_032760 ^@ http://purl.uniprot.org/uniprot/G4VDH7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/6183:Smp_004000 ^@ http://purl.uniprot.org/uniprot/G4V6B8 ^@ Similarity ^@ Belongs to the EIF1AD family. http://togogenome.org/gene/6183:Smp_002600.1 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KBJ8 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/6183:Smp_156880 ^@ http://purl.uniprot.org/uniprot/G4VKC5 ^@ Subcellular Location Annotation ^@ COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6183:Smp_122490 ^@ http://purl.uniprot.org/uniprot/G4V665 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/6183:Smp_103140 ^@ http://purl.uniprot.org/uniprot/Q26444 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/6183:Smp_077090 ^@ http://purl.uniprot.org/uniprot/G4VTX8 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/6183:Smp_010940.1 ^@ http://purl.uniprot.org/uniprot/G4VMR9 ^@ Similarity ^@ Belongs to the ANP32 family. http://togogenome.org/gene/6183:Smp_073560.1 ^@ http://purl.uniprot.org/uniprot/G4V788 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LST8 family.|||Cytoplasm|||Part of TORC1 complex. Part of the TORC2 complex.|||Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. http://togogenome.org/gene/6183:Smp_008770 ^@ http://purl.uniprot.org/uniprot/G4VII4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL42 family.|||Mitochondrion http://togogenome.org/gene/6183:Smp_043320 ^@ http://purl.uniprot.org/uniprot/G4VIY7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6183:Smp_126690 ^@ http://purl.uniprot.org/uniprot/G4V7G0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN6 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.|||Cytoplasm|||Nucleus http://togogenome.org/gene/6183:Smp_097370 ^@ http://purl.uniprot.org/uniprot/G4VML1 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/6183:Smp_142640 ^@ http://purl.uniprot.org/uniprot/G4V655 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the NnrE/AIBP family.|||Binds 1 potassium ion per subunit.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6183:Smp_097210 ^@ http://purl.uniprot.org/uniprot/G4VD04 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/6183:Smp_194870 ^@ http://purl.uniprot.org/uniprot/C4QBN1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6183:Smp_018460 ^@ http://purl.uniprot.org/uniprot/G4VGN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.|||Membrane http://togogenome.org/gene/6183:Smp_027450 ^@ http://purl.uniprot.org/uniprot/G4VIB7 ^@ Similarity ^@ Belongs to the misato family. http://togogenome.org/gene/6183:Smp_096250 ^@ http://purl.uniprot.org/uniprot/A0A5K4F816 ^@ Similarity ^@ Belongs to the BLOC1S1 family. http://togogenome.org/gene/6183:Smp_057060 ^@ http://purl.uniprot.org/uniprot/G4V5J1 ^@ Similarity ^@ Belongs to the acetyl-CoA hydrolase/transferase family. http://togogenome.org/gene/6183:Smp_038030 ^@ http://purl.uniprot.org/uniprot/G4VQX9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/6183:Smp_011150 ^@ http://purl.uniprot.org/uniprot/G4VD96 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/6183:Smp_053830 ^@ http://purl.uniprot.org/uniprot/G4VHS0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/6183:Smp_034490 ^@ http://purl.uniprot.org/uniprot/G4V926 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_132210 ^@ http://purl.uniprot.org/uniprot/G4VGQ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_077070 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KI18 ^@ Similarity ^@ Belongs to the DENR family. http://togogenome.org/gene/6183:Smp_012070 ^@ http://purl.uniprot.org/uniprot/G4VS07 ^@ Similarity ^@ Belongs to the RRP15 family. http://togogenome.org/gene/6183:Smp_130980 ^@ http://purl.uniprot.org/uniprot/G4V5F8 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/6183:Smp_080530 ^@ http://purl.uniprot.org/uniprot/G4VRN3 ^@ Similarity ^@ Belongs to the replication factor A protein 2 family. http://togogenome.org/gene/6183:Smp_038300 ^@ http://purl.uniprot.org/uniprot/G4VNU0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2). Component of the SAGA transcription coactivator-HAT complex. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.|||nucleoplasm http://togogenome.org/gene/6183:Smp_070330 ^@ http://purl.uniprot.org/uniprot/A0A5K4EG51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/6183:Smp_023150 ^@ http://purl.uniprot.org/uniprot/G4VCC1 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/6183:Smp_044850 ^@ http://purl.uniprot.org/uniprot/G4VBK5 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/6183:Smp_135100 ^@ http://purl.uniprot.org/uniprot/G4VD20 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. http://togogenome.org/gene/6183:Smp_015020 ^@ http://purl.uniprot.org/uniprot/G4VGA5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6183:Smp_050590 ^@ http://purl.uniprot.org/uniprot/G4VHI6 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/6183:Smp_015710 ^@ http://purl.uniprot.org/uniprot/G4VSL5 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/6183:Smp_073340 ^@ http://purl.uniprot.org/uniprot/G4VAB5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6183:Smp_087820 ^@ http://purl.uniprot.org/uniprot/G4VLQ6 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/6183:Smp_079770.1 ^@ http://purl.uniprot.org/uniprot/G4VFC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/6183:Smp_148510 ^@ http://purl.uniprot.org/uniprot/G4VC21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/6183:Smp_093440 ^@ http://purl.uniprot.org/uniprot/G4V605 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/6183:Smp_042020.1 ^@ http://purl.uniprot.org/uniprot/Q7YTA4 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/6183:Smp_047640 ^@ http://purl.uniprot.org/uniprot/G4VBG7 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/6183:Smp_033540 ^@ http://purl.uniprot.org/uniprot/G4VQT7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/6183:Smp_022990 ^@ http://purl.uniprot.org/uniprot/G4VN15 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/6183:Smp_210280 ^@ http://purl.uniprot.org/uniprot/G4VJK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCTS1 family.|||Cytoplasm http://togogenome.org/gene/6183:Smp_144030 ^@ http://purl.uniprot.org/uniprot/G4VKI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Membrane http://togogenome.org/gene/6183:Smp_055960 ^@ http://purl.uniprot.org/uniprot/G4VB90 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/6183:Smp_054330 ^@ http://purl.uniprot.org/uniprot/G4VQK3 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/6183:Smp_175230 ^@ http://purl.uniprot.org/uniprot/G4VJD6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dihydrofolate reductase family.|||Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.|||Monomer. http://togogenome.org/gene/6183:Smp_045260 ^@ http://purl.uniprot.org/uniprot/G4VBS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_152790 ^@ http://purl.uniprot.org/uniprot/G4V5J2 ^@ Similarity ^@ Belongs to the GTR/RAG GTP-binding protein family. http://togogenome.org/gene/6183:Smp_055310 ^@ http://purl.uniprot.org/uniprot/G4V5N4 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/6183:Smp_083130 ^@ http://purl.uniprot.org/uniprot/G4V7E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/6183:Smp_192110 ^@ http://purl.uniprot.org/uniprot/G4VHK8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/6183:Smp_165830 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KS17 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/6183:Smp_074780 ^@ http://purl.uniprot.org/uniprot/G4VH28 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS13 family. http://togogenome.org/gene/6183:Smp_052750 ^@ http://purl.uniprot.org/uniprot/G4VM35 ^@ Similarity ^@ Belongs to the fl(2)d family. http://togogenome.org/gene/6183:Smp_068110 ^@ http://purl.uniprot.org/uniprot/G4V6Q2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MRE11/RAD32 family.|||Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.|||Nucleus http://togogenome.org/gene/6183:Smp_124230 ^@ http://purl.uniprot.org/uniprot/G4V6K0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. DMC1 subfamily.|||Belongs to the RecA family. RAD51 subfamily.|||Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.|||Nucleus http://togogenome.org/gene/6183:Smp_095130 ^@ http://purl.uniprot.org/uniprot/G4VRL5 ^@ Similarity ^@ Belongs to the HMBS family. http://togogenome.org/gene/6183:Smp_028670.1 ^@ http://purl.uniprot.org/uniprot/G4VP62 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/6183:Smp_163170 ^@ http://purl.uniprot.org/uniprot/G4VSU9 ^@ Similarity ^@ Belongs to the X(+)/potassium ATPases subunit beta family. http://togogenome.org/gene/6183:Smp_030220 ^@ http://purl.uniprot.org/uniprot/A0A7S9YVD6 ^@ Cofactor|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||Divalent metal ions. Mg(2+) is the most effective. http://togogenome.org/gene/6183:Smp_121920 ^@ http://purl.uniprot.org/uniprot/G4VGD1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_128690 ^@ http://purl.uniprot.org/uniprot/G4VS85 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvP family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/6183:Smp_083720 ^@ http://purl.uniprot.org/uniprot/G4V6T6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_178360 ^@ http://purl.uniprot.org/uniprot/G4VPC4 ^@ Similarity ^@ Belongs to the UFL1 family. http://togogenome.org/gene/6183:Smp_151410 ^@ http://purl.uniprot.org/uniprot/G4V7T7 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/6183:Smp_054410 ^@ http://purl.uniprot.org/uniprot/G4VQJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm http://togogenome.org/gene/6183:Smp_151030 ^@ http://purl.uniprot.org/uniprot/G4VHQ2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/6183:Smp_151210 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KPW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/6183:Smp_066760.1 ^@ http://purl.uniprot.org/uniprot/G4VND1 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/6183:Smp_210410 ^@ http://purl.uniprot.org/uniprot/A0A5K4F327 ^@ Similarity ^@ Belongs to the parvin family. http://togogenome.org/gene/6183:Smp_022560.1 ^@ http://purl.uniprot.org/uniprot/G4VEA9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/6183:Smp_002180.1 ^@ http://purl.uniprot.org/uniprot/G4VLL3 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/6183:Smp_087270 ^@ http://purl.uniprot.org/uniprot/G4VJG1 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily. http://togogenome.org/gene/6183:Smp_054010 ^@ http://purl.uniprot.org/uniprot/G4VHR0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_055200 ^@ http://purl.uniprot.org/uniprot/G4VH66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6183:Smp_148440 ^@ http://purl.uniprot.org/uniprot/A0A5K4FD37 ^@ Similarity ^@ Belongs to the CSN12 family. http://togogenome.org/gene/6183:Smp_103100 ^@ http://purl.uniprot.org/uniprot/G4VTQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin interacting component (NIC) family.|||nuclear pore complex http://togogenome.org/gene/6183:Smp_067520 ^@ http://purl.uniprot.org/uniprot/G4VQC3 ^@ Similarity ^@ Belongs to the bZIP family. Jun subfamily. http://togogenome.org/gene/6183:Smp_092880.1 ^@ http://purl.uniprot.org/uniprot/G4VE77 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_059930 ^@ http://purl.uniprot.org/uniprot/G4VT15 ^@ Similarity ^@ Belongs to the UQCRH/QCR6 family. http://togogenome.org/gene/6183:Smp_050830 ^@ http://purl.uniprot.org/uniprot/G4VIB3 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family. http://togogenome.org/gene/6183:Smp_022090 ^@ http://purl.uniprot.org/uniprot/G4VE33 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/6183:Smp_062890 ^@ http://purl.uniprot.org/uniprot/G4VHU7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||Vacuole membrane http://togogenome.org/gene/6183:Smp_076740 ^@ http://purl.uniprot.org/uniprot/G4VGR1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/6183:Smp_168400 ^@ http://purl.uniprot.org/uniprot/G4V7D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mis12 family.|||kinetochore http://togogenome.org/gene/6183:Smp_095500 ^@ http://purl.uniprot.org/uniprot/G4V851 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/6183:Smp_023010 ^@ http://purl.uniprot.org/uniprot/Q26549 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase inhibitor family.|||Mitochondrion http://togogenome.org/gene/6183:Smp_002870 ^@ http://purl.uniprot.org/uniprot/G4VLJ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_011560 ^@ http://purl.uniprot.org/uniprot/G4VS95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/6183:Smp_102390 ^@ http://purl.uniprot.org/uniprot/G4VBF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP96 family.|||centrosome http://togogenome.org/gene/6183:Smp_033400 ^@ http://purl.uniprot.org/uniprot/Q15EU2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space http://togogenome.org/gene/6183:Smp_002550.1 ^@ http://purl.uniprot.org/uniprot/G4VF55 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBM8A family.|||Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.|||Cytoplasm|||Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.|||Nucleus|||Nucleus speckle http://togogenome.org/gene/6183:Smp_012050 ^@ http://purl.uniprot.org/uniprot/G4VS05 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/6183:Smp_012380 ^@ http://purl.uniprot.org/uniprot/G4VC52 ^@ Similarity ^@ Belongs to the shaker potassium channel beta subunit family. http://togogenome.org/gene/6183:Smp_037910 ^@ http://purl.uniprot.org/uniprot/G4V6D5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CybS family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/6183:KEF69_p05 ^@ http://purl.uniprot.org/uniprot/Q9B8X3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome b family.|||Binds 2 heme groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_018490 ^@ http://purl.uniprot.org/uniprot/G4VGN3 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be a regulator of keratinocyte proliferation or differentiation.|||Nucleus http://togogenome.org/gene/6183:Smp_130630 ^@ http://purl.uniprot.org/uniprot/G4VSD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EAF7 family.|||Nucleus http://togogenome.org/gene/6183:Smp_049300.1 ^@ http://purl.uniprot.org/uniprot/G4V8Y7 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/6183:Smp_027250 ^@ http://purl.uniprot.org/uniprot/G4VHC2 ^@ Similarity ^@ Belongs to the SMAP family. http://togogenome.org/gene/6183:Smp_104580 ^@ http://purl.uniprot.org/uniprot/G4VE51 ^@ Cofactor|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/6183:Smp_031220 ^@ http://purl.uniprot.org/uniprot/G4VPL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/6183:Smp_141610 ^@ http://purl.uniprot.org/uniprot/Q95PM1 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6183:Smp_027370 ^@ http://purl.uniprot.org/uniprot/G4VHA9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/6183:Smp_179660 ^@ http://purl.uniprot.org/uniprot/G4VDS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane http://togogenome.org/gene/6183:Smp_091740.1 ^@ http://purl.uniprot.org/uniprot/G4VLM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/6183:Smp_077230 ^@ http://purl.uniprot.org/uniprot/G4VTW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOSR1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/6183:Smp_014780.1 ^@ http://purl.uniprot.org/uniprot/G4VBW4 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/6183:Smp_102070 ^@ http://purl.uniprot.org/uniprot/P35661 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GST superfamily. Mu family.|||Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.|||GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.|||Homodimer. http://togogenome.org/gene/6183:Smp_053030 ^@ http://purl.uniprot.org/uniprot/G4VK07 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS36 family.|||Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II).|||Cytoplasm|||Endosome http://togogenome.org/gene/6183:Smp_208010 ^@ http://purl.uniprot.org/uniprot/G4VDB2 ^@ Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family.|||Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences. http://togogenome.org/gene/6183:Smp_155360 ^@ http://purl.uniprot.org/uniprot/G4VNJ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_000810.1 ^@ http://purl.uniprot.org/uniprot/G4V664 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/6183:Smp_090690 ^@ http://purl.uniprot.org/uniprot/G4VJ82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTU2/NCS2 family.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. http://togogenome.org/gene/6183:Smp_070680 ^@ http://purl.uniprot.org/uniprot/G4VEL0 ^@ Similarity ^@ Belongs to the MAF1 family. http://togogenome.org/gene/6183:Smp_082660 ^@ http://purl.uniprot.org/uniprot/G4VC92 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/6183:Smp_007970 ^@ http://purl.uniprot.org/uniprot/G4VJ59 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/6183:Smp_071610 ^@ http://purl.uniprot.org/uniprot/G4VRT6 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/6183:Smp_079640 ^@ http://purl.uniprot.org/uniprot/G4V7W3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_023530 ^@ http://purl.uniprot.org/uniprot/A0A5K4F8R8 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/6183:Smp_096900 ^@ http://purl.uniprot.org/uniprot/G4VBL5 ^@ Similarity ^@ Belongs to the PPR family. P subfamily. http://togogenome.org/gene/6183:Smp_061100 ^@ http://purl.uniprot.org/uniprot/G4V868 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/6183:Smp_031270.1 ^@ http://purl.uniprot.org/uniprot/G4VPM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/6183:Smp_042030.1 ^@ http://purl.uniprot.org/uniprot/G4VJS4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_126020 ^@ http://purl.uniprot.org/uniprot/G4VB23 ^@ Similarity|||Subunit ^@ Belongs to the class-I fumarase family.|||Homodimer. http://togogenome.org/gene/6183:Smp_211090 ^@ http://purl.uniprot.org/uniprot/G4VBH5 ^@ Similarity ^@ Belongs to the prokaryotic/mitochondrial release factor family. http://togogenome.org/gene/6183:Smp_201470 ^@ http://purl.uniprot.org/uniprot/G4VBU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMCO4 family.|||Membrane http://togogenome.org/gene/6183:Smp_018990 ^@ http://purl.uniprot.org/uniprot/G4VG38 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/6183:Smp_135570 ^@ http://purl.uniprot.org/uniprot/G4VIR8 ^@ Function|||Similarity ^@ Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.|||Belongs to the actin family. http://togogenome.org/gene/6183:Smp_079430.1 ^@ http://purl.uniprot.org/uniprot/G4V793 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ran family.|||GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.|||Nucleus http://togogenome.org/gene/6183:Smp_010370 ^@ http://purl.uniprot.org/uniprot/G4VML4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/6183:Smp_161960 ^@ http://purl.uniprot.org/uniprot/G4V783 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SDE2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/6183:Smp_045550 ^@ http://purl.uniprot.org/uniprot/G4VI63 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/6183:Smp_038080.1 ^@ http://purl.uniprot.org/uniprot/G4VHN1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/6183:Smp_079730 ^@ http://purl.uniprot.org/uniprot/G4VFB6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_077860 ^@ http://purl.uniprot.org/uniprot/G4VL77 ^@ Function|||Similarity ^@ Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.|||Belongs to the actin family. http://togogenome.org/gene/6183:Smp_034010 ^@ http://purl.uniprot.org/uniprot/G4V9T7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6183:Smp_035270.1 ^@ http://purl.uniprot.org/uniprot/G4V7Z7 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family. http://togogenome.org/gene/6183:Smp_092810.1 ^@ http://purl.uniprot.org/uniprot/G4VEZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/6183:Smp_134460 ^@ http://purl.uniprot.org/uniprot/G4VI72 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6183:Smp_129080 ^@ http://purl.uniprot.org/uniprot/G4V9I3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase g subunit family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion http://togogenome.org/gene/6183:Smp_089240 ^@ http://purl.uniprot.org/uniprot/G4VAB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 16 (GT16) protein family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/6183:Smp_142490 ^@ http://purl.uniprot.org/uniprot/G4VE75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/6183:Smp_071020 ^@ http://purl.uniprot.org/uniprot/G4V7X1 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/6183:Smp_043200 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KF34 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/6183:Smp_151020 ^@ http://purl.uniprot.org/uniprot/G4VHQ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_092770 ^@ http://purl.uniprot.org/uniprot/G4V6J3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/6183:Smp_147120 ^@ http://purl.uniprot.org/uniprot/G4VLV7 ^@ Similarity ^@ Belongs to the DDRGK1 family. http://togogenome.org/gene/6183:Smp_043670.1 ^@ http://purl.uniprot.org/uniprot/G4VKA6 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6183:Smp_151690 ^@ http://purl.uniprot.org/uniprot/G4VND5 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/6183:Smp_074050 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KHR7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_090150.1 ^@ http://purl.uniprot.org/uniprot/G4VHV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. http://togogenome.org/gene/6183:Smp_084460 ^@ http://purl.uniprot.org/uniprot/G4VSC8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL28 family. http://togogenome.org/gene/6183:Smp_066960.1 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KH23 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit beta family. http://togogenome.org/gene/6183:Smp_004680 ^@ http://purl.uniprot.org/uniprot/G4VD50 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/6183:Smp_127710 ^@ http://purl.uniprot.org/uniprot/G4VMM4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6183:Smp_089860 ^@ http://purl.uniprot.org/uniprot/C4QHD7 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6183:Smp_072350 ^@ http://purl.uniprot.org/uniprot/G4V9B4 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/6183:Smp_008360 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KC34 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.|||Belongs to the carbohydrate kinase PfkB family.|||Binds 3 Mg(2+) ions per subunit.|||Monomer.|||Nucleus http://togogenome.org/gene/6183:Smp_077590 ^@ http://purl.uniprot.org/uniprot/G4VL53 ^@ Similarity ^@ Belongs to the CWC26 family. http://togogenome.org/gene/6183:Smp_210840 ^@ http://purl.uniprot.org/uniprot/A0A5K4FED0 ^@ Similarity ^@ Belongs to the WD repeat ATG16 family. http://togogenome.org/gene/6183:Smp_035200.1 ^@ http://purl.uniprot.org/uniprot/G4V805 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_064520 ^@ http://purl.uniprot.org/uniprot/G4VKB5 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/6183:Smp_160210 ^@ http://purl.uniprot.org/uniprot/G4VJB9 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/6183:Smp_060010 ^@ http://purl.uniprot.org/uniprot/G4VAK6 ^@ Subcellular Location Annotation ^@ Golgi stack http://togogenome.org/gene/6183:Smp_106060 ^@ http://purl.uniprot.org/uniprot/G4VEN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_017830.1 ^@ http://purl.uniprot.org/uniprot/G4VNQ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS5 subunit family.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_136970 ^@ http://purl.uniprot.org/uniprot/G4VHB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Nucleus http://togogenome.org/gene/6183:Smp_030250 ^@ http://purl.uniprot.org/uniprot/Q26561 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NFYA/HAP2 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.|||Heterotrimer.|||Nucleus http://togogenome.org/gene/6183:Smp_056440 ^@ http://purl.uniprot.org/uniprot/G4VSQ5 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems.|||Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/6183:Smp_024010 ^@ http://purl.uniprot.org/uniprot/G4VQ47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/6183:Smp_011570.1 ^@ http://purl.uniprot.org/uniprot/G4VS96 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/6183:Smp_075210.1 ^@ http://purl.uniprot.org/uniprot/G4VS58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_154960.1 ^@ http://purl.uniprot.org/uniprot/G4V867 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/6183:Smp_031720 ^@ http://purl.uniprot.org/uniprot/G4VN61 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6183:Smp_134950 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KMH4 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/6183:Smp_012440 ^@ http://purl.uniprot.org/uniprot/Q26579 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/6183:Smp_015440 ^@ http://purl.uniprot.org/uniprot/G4VRR8 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/6183:Smp_070200 ^@ http://purl.uniprot.org/uniprot/G4VJB4 ^@ Similarity ^@ Belongs to the splicing factor SR family. http://togogenome.org/gene/6183:Smp_087930 ^@ http://purl.uniprot.org/uniprot/G4VLR8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_181470 ^@ http://purl.uniprot.org/uniprot/G4VEN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/6183:Smp_071000 ^@ http://purl.uniprot.org/uniprot/G4VJ62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DSS1/SEM1 family.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.|||Nucleus http://togogenome.org/gene/6183:Smp_024180.1 ^@ http://purl.uniprot.org/uniprot/G4VQ69 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/6183:Smp_048270.1 ^@ http://purl.uniprot.org/uniprot/A0A5K4F9P0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dolichyldiphosphatase family.|||Endoplasmic reticulum membrane|||Membrane|||Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. http://togogenome.org/gene/6183:Smp_130170 ^@ http://purl.uniprot.org/uniprot/G4VBV9 ^@ Similarity ^@ Belongs to the ubiquitin family. http://togogenome.org/gene/6183:Smp_097240.1 ^@ http://purl.uniprot.org/uniprot/G4V8U3 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/6183:Smp_123165 ^@ http://purl.uniprot.org/uniprot/G4VLH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunit 4 family.|||cell cortex|||centrosome|||sarcomere|||stress fiber http://togogenome.org/gene/6183:Smp_126920 ^@ http://purl.uniprot.org/uniprot/G4VIF5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_168930 ^@ http://purl.uniprot.org/uniprot/G4V875 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane http://togogenome.org/gene/6183:Smp_065150 ^@ http://purl.uniprot.org/uniprot/G4VCR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. ECO subfamily.|||Nucleus http://togogenome.org/gene/6183:Smp_055670 ^@ http://purl.uniprot.org/uniprot/G4VHJ2 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/6183:Smp_100080 ^@ http://purl.uniprot.org/uniprot/G4VG77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/6183:Smp_103790 ^@ http://purl.uniprot.org/uniprot/G4V865 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/6183:Smp_095910 ^@ http://purl.uniprot.org/uniprot/G4VDN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6183:Smp_061500 ^@ http://purl.uniprot.org/uniprot/G4VKK8 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. METL family. http://togogenome.org/gene/6183:Smp_147400 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KPB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/6183:Smp_172240 ^@ http://purl.uniprot.org/uniprot/A0A3Q0KT26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/6183:Smp_005740 ^@ http://purl.uniprot.org/uniprot/C4PYI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/6183:Smp_158520 ^@ http://purl.uniprot.org/uniprot/G4V6S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/6183:Smp_158190 ^@ http://purl.uniprot.org/uniprot/G4VM07 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_018210 ^@ http://purl.uniprot.org/uniprot/G4VP16 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6183:Smp_038630 ^@ http://purl.uniprot.org/uniprot/G4VI93 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM22 complex.|||Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6183:Smp_046900 ^@ http://purl.uniprot.org/uniprot/G4VCL9 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6183:Smp_046680 ^@ http://purl.uniprot.org/uniprot/G4VCP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat UTP18 family.|||nucleolus http://togogenome.org/gene/6183:Smp_066340.1 ^@ http://purl.uniprot.org/uniprot/G4VGG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the proteasome inhibitor PI31 family.|||Cytoplasm http://togogenome.org/gene/6183:Smp_058130.1 ^@ http://purl.uniprot.org/uniprot/G4VK41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/6183:Smp_143670 ^@ http://purl.uniprot.org/uniprot/G4VKF6 ^@ Similarity ^@ Belongs to the RRN3 family. http://togogenome.org/gene/6183:Smp_068420 ^@ http://purl.uniprot.org/uniprot/Q4JHT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/6183:Smp_084060 ^@ http://purl.uniprot.org/uniprot/G4VRF4 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/6183:Smp_029750 ^@ http://purl.uniprot.org/uniprot/G4VFH7 ^@ Function|||Similarity ^@ Belongs to the TSR2 family.|||May be involved in 20S pre-rRNA processing. http://togogenome.org/gene/6183:Smp_014280 ^@ http://purl.uniprot.org/uniprot/G4V8T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/6183:Smp_112520 ^@ http://purl.uniprot.org/uniprot/G4VPC5 ^@ Similarity ^@ Belongs to the UFL1 family. http://togogenome.org/gene/6183:Smp_014080 ^@ http://purl.uniprot.org/uniprot/G4VS33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/6183:Smp_118220 ^@ http://purl.uniprot.org/uniprot/G4V772 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/6183:Smp_070170 ^@ http://purl.uniprot.org/uniprot/G4VJB5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6183:Smp_210790 ^@ http://purl.uniprot.org/uniprot/G4V7Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/6183:Smp_165980 ^@ http://purl.uniprot.org/uniprot/G4V8N6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/6183:Smp_034410.1 ^@ http://purl.uniprot.org/uniprot/G4VBC4 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6183:Smp_047620 ^@ http://purl.uniprot.org/uniprot/G4VBG9 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/6183:Smp_034120 ^@ http://purl.uniprot.org/uniprot/G4V9U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||synaptosome http://togogenome.org/gene/6183:Smp_084090 ^@ http://purl.uniprot.org/uniprot/G4VRF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6183:KEF69_p09 ^@ http://purl.uniprot.org/uniprot/Q9B8X7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Membrane http://togogenome.org/gene/6183:Smp_155740 ^@ http://purl.uniprot.org/uniprot/G4VJ99 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/6183:Smp_141330 ^@ http://purl.uniprot.org/uniprot/G4V7P9 ^@ Similarity ^@ Belongs to the U2 small nuclear ribonucleoprotein A family. http://togogenome.org/gene/6183:Smp_034190.1 ^@ http://purl.uniprot.org/uniprot/G4VEF4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/6183:Smp_055190 ^@ http://purl.uniprot.org/uniprot/G4VH67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/6183:Smp_040270 ^@ http://purl.uniprot.org/uniprot/G4VAW5 ^@ Similarity ^@ Belongs to the LTV1 family. http://togogenome.org/gene/6183:Smp_045930 ^@ http://purl.uniprot.org/uniprot/G4VPQ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6183:Smp_200020 ^@ http://purl.uniprot.org/uniprot/G4V8Z0 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/6183:Smp_143060 ^@ http://purl.uniprot.org/uniprot/G4VTG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cell membrane|||coated pit