http://togogenome.org/gene/61853:GDF10 ^@ http://purl.uniprot.org/uniprot/G1RZT3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer.|||Secreted http://togogenome.org/gene/61853:MOB3C ^@ http://purl.uniprot.org/uniprot/G1S359 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/61853:ZC3HC1 ^@ http://purl.uniprot.org/uniprot/G1RQB1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:UBE2G2 ^@ http://purl.uniprot.org/uniprot/M3Z9V5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/61853:STK32C ^@ http://purl.uniprot.org/uniprot/G1QMP0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:AGTRAP ^@ http://purl.uniprot.org/uniprot/G1REV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:TGS1 ^@ http://purl.uniprot.org/uniprot/G1QK83 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family. http://togogenome.org/gene/61853:ATP5F1E ^@ http://purl.uniprot.org/uniprot/G1SAJ2 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ATPase epsilon family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/61853:NUDT5 ^@ http://purl.uniprot.org/uniprot/A0A2I3HME7 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/61853:LOC100590716 ^@ http://purl.uniprot.org/uniprot/A0A2I3GI08 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL10 family. http://togogenome.org/gene/61853:ADGRF5 ^@ http://purl.uniprot.org/uniprot/G1QWL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/61853:MFSD9 ^@ http://purl.uniprot.org/uniprot/G1RXB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/61853:FUT11 ^@ http://purl.uniprot.org/uniprot/G1S471 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane|||Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. http://togogenome.org/gene/61853:DERL2 ^@ http://purl.uniprot.org/uniprot/G1RD08 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:SERPINH1 ^@ http://purl.uniprot.org/uniprot/G1S4S0 ^@ Function|||Similarity ^@ Belongs to the serpin family.|||Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. http://togogenome.org/gene/61853:ERAP1 ^@ http://purl.uniprot.org/uniprot/G1RV93 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/61853:FOXP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H606|||http://purl.uniprot.org/uniprot/A0A2I3H9H6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:AP4B1 ^@ http://purl.uniprot.org/uniprot/G1QX99 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/61853:KIF9 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBM7|||http://purl.uniprot.org/uniprot/G1R385 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/61853:TAF2 ^@ http://purl.uniprot.org/uniprot/M3ZBV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF2 family.|||Nucleus http://togogenome.org/gene/61853:TDRD5 ^@ http://purl.uniprot.org/uniprot/A0A2I3HG77|||http://purl.uniprot.org/uniprot/G1S0W5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TDRD5 family.|||Cytoplasm|||Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly. http://togogenome.org/gene/61853:TRMT13 ^@ http://purl.uniprot.org/uniprot/A0A2I3HEU0 ^@ Function|||Similarity ^@ Belongs to the methyltransferase TRM13 family.|||tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). http://togogenome.org/gene/61853:MARCHF4 ^@ http://purl.uniprot.org/uniprot/G1R6P1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:LOC100582745 ^@ http://purl.uniprot.org/uniprot/G1SB41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/61853:DCP1B ^@ http://purl.uniprot.org/uniprot/G1QQS6 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/61853:FRZB ^@ http://purl.uniprot.org/uniprot/G1R3H6 ^@ Caution|||Function|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. http://togogenome.org/gene/61853:TRIAP1 ^@ http://purl.uniprot.org/uniprot/G1S0E4 ^@ Similarity ^@ Belongs to the TRIAP1/MDM35 family. http://togogenome.org/gene/61853:ZC3H15 ^@ http://purl.uniprot.org/uniprot/G1R3T6 ^@ Similarity ^@ Belongs to the ZC3H15/TMA46 family. http://togogenome.org/gene/61853:ZIC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HPN9 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/61853:PCYOX1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GZ46 ^@ Similarity ^@ Belongs to the prenylcysteine oxidase family. http://togogenome.org/gene/61853:TMEM251 ^@ http://purl.uniprot.org/uniprot/A0A2I3HY88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LYSET family.|||Membrane http://togogenome.org/gene/61853:P2RY11 ^@ http://purl.uniprot.org/uniprot/A0A2I3FUK3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:CFB ^@ http://purl.uniprot.org/uniprot/M3Z963 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:PDE6A ^@ http://purl.uniprot.org/uniprot/A0A2I3HF42|||http://purl.uniprot.org/uniprot/G1RGT6 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/61853:TMEM106C ^@ http://purl.uniprot.org/uniprot/G1S8A6 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/61853:ZNF500 ^@ http://purl.uniprot.org/uniprot/A0A2I3HQU0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:TGFB1 ^@ http://purl.uniprot.org/uniprot/G1RTT5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.|||extracellular matrix http://togogenome.org/gene/61853:ELOVL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GT94 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ELO family. ELOVL1 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.|||Endoplasmic reticulum membrane|||Interacts with LASS2, TECR and HSD17B12.|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/61853:DENND6A ^@ http://purl.uniprot.org/uniprot/M3ZBR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND6 family.|||Recycling endosome http://togogenome.org/gene/61853:CLCN6 ^@ http://purl.uniprot.org/uniprot/G1RF19 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:CDK5R2 ^@ http://purl.uniprot.org/uniprot/G1SAQ5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cyclin-dependent kinase 5 activator family.|||Cell membrane|||Heterodimer of a catalytic subunit and a regulatory subunit.|||Membrane http://togogenome.org/gene/61853:LOC100589053 ^@ http://purl.uniprot.org/uniprot/G1RXP9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/61853:REV1 ^@ http://purl.uniprot.org/uniprot/G1RVV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-Y family.|||Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.|||Nucleus http://togogenome.org/gene/61853:INHA ^@ http://purl.uniprot.org/uniprot/G1REI3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.|||Secreted http://togogenome.org/gene/61853:LOC100579523 ^@ http://purl.uniprot.org/uniprot/G1R2C4 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/61853:ATP11C ^@ http://purl.uniprot.org/uniprot/A0A2I3G4I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/61853:MAP3K7 ^@ http://purl.uniprot.org/uniprot/A0A2I3GLG2|||http://purl.uniprot.org/uniprot/G1RSQ0 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.|||Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Cytoplasm http://togogenome.org/gene/61853:CNR2 ^@ http://purl.uniprot.org/uniprot/G1RBV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:PTEN ^@ http://purl.uniprot.org/uniprot/G1RNC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4.|||Belongs to the PTEN phosphatase protein family.|||Cytoplasm|||Nucleus|||PML body|||Postsynaptic density|||dendritic spine http://togogenome.org/gene/61853:IFNA2 ^@ http://purl.uniprot.org/uniprot/A0A7R8C3C3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/61853:GCNT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GQ26 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:GPN1 ^@ http://purl.uniprot.org/uniprot/G1QV73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II.|||Cytoplasm|||Nucleus|||Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/61853:PSMB5 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBS2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:UTP6 ^@ http://purl.uniprot.org/uniprot/A0A2I3HCI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP6 family.|||nucleolus http://togogenome.org/gene/61853:POP7 ^@ http://purl.uniprot.org/uniprot/G1RMN6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone-like Alba family.|||Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.|||Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.|||Cytoplasmic granule|||nucleolus http://togogenome.org/gene/61853:PTGES3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HU89|||http://purl.uniprot.org/uniprot/G1S6N9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the p23/wos2 family.|||Cytoplasm|||Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.|||Forms a complex with HSP70, HSP90 and other chaperones. http://togogenome.org/gene/61853:SMIM19 ^@ http://purl.uniprot.org/uniprot/A0A2I3H174 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM19 family.|||Membrane http://togogenome.org/gene/61853:C4H18orf21 ^@ http://purl.uniprot.org/uniprot/A0A2I3GKV6 ^@ Similarity ^@ Belongs to the UPF0711 family. http://togogenome.org/gene/61853:RPS24 ^@ http://purl.uniprot.org/uniprot/A0A2I3HLL8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/61853:SLC25A27 ^@ http://purl.uniprot.org/uniprot/G1QX17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/61853:MRPL15 ^@ http://purl.uniprot.org/uniprot/A0A2I3G0R3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/61853:LAMA4 ^@ http://purl.uniprot.org/uniprot/G1RRG8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/61853:TARS1 ^@ http://purl.uniprot.org/uniprot/G1RVM5 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/61853:DNAJA4 ^@ http://purl.uniprot.org/uniprot/G1RAW1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:CRYBG1 ^@ http://purl.uniprot.org/uniprot/G1RSC9 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/61853:TMEM17 ^@ http://purl.uniprot.org/uniprot/G1RF86 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:LETM2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HJU9 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:ID2 ^@ http://purl.uniprot.org/uniprot/G1RRW6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:IMMP2L ^@ http://purl.uniprot.org/uniprot/A0A2I3G9X9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family. IMP2 subfamily.|||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:SLC18B1 ^@ http://purl.uniprot.org/uniprot/G1RWY7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:GMNN ^@ http://purl.uniprot.org/uniprot/A0A2I3HRC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the geminin family.|||Nucleus http://togogenome.org/gene/61853:HSPA8 ^@ http://purl.uniprot.org/uniprot/A0A2I3HNE7 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/61853:RBM5 ^@ http://purl.uniprot.org/uniprot/A0A2I3G2U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBM5/RBM10 family.|||Nucleus http://togogenome.org/gene/61853:FAM53B ^@ http://purl.uniprot.org/uniprot/G1QI75 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/61853:LOC100587724 ^@ http://purl.uniprot.org/uniprot/A0A2I3HHT9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:TCN1 ^@ http://purl.uniprot.org/uniprot/G1RRV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/61853:EDEM3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GBI7|||http://purl.uniprot.org/uniprot/G1S8R1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/61853:NEK8 ^@ http://purl.uniprot.org/uniprot/G1QRK6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. http://togogenome.org/gene/61853:ADSS1 ^@ http://purl.uniprot.org/uniprot/G1S2R9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.|||Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. http://togogenome.org/gene/61853:DESI2 ^@ http://purl.uniprot.org/uniprot/G1QV90 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/61853:LOC100605123 ^@ http://purl.uniprot.org/uniprot/G1QJQ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:CFAP97 ^@ http://purl.uniprot.org/uniprot/A0A2I3HR42 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/61853:PPFIBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H4U3|||http://purl.uniprot.org/uniprot/A0A2I3HQ68 ^@ Similarity ^@ Belongs to the liprin family. Liprin-beta subfamily. http://togogenome.org/gene/61853:ANP32A ^@ http://purl.uniprot.org/uniprot/G1RSJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/61853:CFAP36 ^@ http://purl.uniprot.org/uniprot/A0A2I3HQF6 ^@ Similarity ^@ Belongs to the CFAP36 family. http://togogenome.org/gene/61853:CRY1 ^@ http://purl.uniprot.org/uniprot/G1R4R9 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/61853:CAMP ^@ http://purl.uniprot.org/uniprot/G1R3M3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Exhibits antimicrobial activity against E.coli and B.megaterium (in vitro).|||Secreted|||Vesicle http://togogenome.org/gene/61853:NAF1 ^@ http://purl.uniprot.org/uniprot/G1R3T8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAF1 family.|||Nucleus http://togogenome.org/gene/61853:HTR3E ^@ http://purl.uniprot.org/uniprot/A0A2I3HBI9|||http://purl.uniprot.org/uniprot/G1R2H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/61853:POLR1B ^@ http://purl.uniprot.org/uniprot/A0A2I3GC16|||http://purl.uniprot.org/uniprot/A0A2I3HKQ5 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft. http://togogenome.org/gene/61853:ARF3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GEQ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/61853:GHRL ^@ http://purl.uniprot.org/uniprot/G1QWU2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the motilin family.|||Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.|||O-octanoylation is essential for ghrelin activity.|||Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.|||Secreted http://togogenome.org/gene/61853:COL4A6 ^@ http://purl.uniprot.org/uniprot/A0A2I3G8L8|||http://purl.uniprot.org/uniprot/A0A2I3HT29|||http://purl.uniprot.org/uniprot/G1RVH3|||http://purl.uniprot.org/uniprot/M3ZCH1 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/61853:LPCAT3 ^@ http://purl.uniprot.org/uniprot/G1QZ09 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:ICAM4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GGM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/61853:OC90 ^@ http://purl.uniprot.org/uniprot/G1R175 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/61853:HHAT ^@ http://purl.uniprot.org/uniprot/A0A2I3GE49|||http://purl.uniprot.org/uniprot/A0A2I3HK24|||http://purl.uniprot.org/uniprot/G1QPJ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:GJA1 ^@ http://purl.uniprot.org/uniprot/A0A654IE97 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Endoplasmic reticulum|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/61853:KCNK16 ^@ http://purl.uniprot.org/uniprot/A0A2I3HQ07|||http://purl.uniprot.org/uniprot/A0A2I3HWV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/61853:S100A7 ^@ http://purl.uniprot.org/uniprot/G1RHF4 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/61853:LGI1 ^@ http://purl.uniprot.org/uniprot/G1RQZ5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/61853:TUBB1 ^@ http://purl.uniprot.org/uniprot/G1REK1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/61853:SULT4A1 ^@ http://purl.uniprot.org/uniprot/G1S0E7 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/61853:LRRFIP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GP66 ^@ Similarity ^@ Belongs to the LRRFIP family. http://togogenome.org/gene/61853:LOC100580435 ^@ http://purl.uniprot.org/uniprot/G1S6C6 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/61853:LOC100604545 ^@ http://purl.uniprot.org/uniprot/G1RHM6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme c group covalently per subunit.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:PSMB7 ^@ http://purl.uniprot.org/uniprot/A0A2I3HSC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:CCNJL ^@ http://purl.uniprot.org/uniprot/A0A2I3HMK6 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/61853:SMDT1 ^@ http://purl.uniprot.org/uniprot/G1S0Y2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMDT1/EMRE family.|||Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.|||Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:PVALB ^@ http://purl.uniprot.org/uniprot/G1RX85 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/61853:CALHM4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HUP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/61853:PIK3R3 ^@ http://purl.uniprot.org/uniprot/G1S3Y6 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/61853:PTCH1 ^@ http://purl.uniprot.org/uniprot/G1S4D5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/61853:SLC17A2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HTT9|||http://purl.uniprot.org/uniprot/G1QRV0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:PPP1R14A ^@ http://purl.uniprot.org/uniprot/G1S4X8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PP1 inhibitor family.|||Cytoplasm|||Inhibitor of PPP1CA. http://togogenome.org/gene/61853:TLR2 ^@ http://purl.uniprot.org/uniprot/G1SB95 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Toll-like receptor family.|||Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). http://togogenome.org/gene/61853:SLC26A3 ^@ http://purl.uniprot.org/uniprot/G1RBF7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.|||Membrane http://togogenome.org/gene/61853:LAMTOR2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G399|||http://purl.uniprot.org/uniprot/A0A2I3GK13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAMAD family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/61853:TMTC2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GTR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/61853:CAV3 ^@ http://purl.uniprot.org/uniprot/G1QUD3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/61853:ACER2 ^@ http://purl.uniprot.org/uniprot/G1S6Y4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:FSCN3 ^@ http://purl.uniprot.org/uniprot/G1RNR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/61853:CHURC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GPA9|||http://purl.uniprot.org/uniprot/A0A2I3HWK9 ^@ Similarity ^@ Belongs to the Churchill family. http://togogenome.org/gene/61853:GPR18 ^@ http://purl.uniprot.org/uniprot/G1R945 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:YOD1 ^@ http://purl.uniprot.org/uniprot/G1QJN7 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin. http://togogenome.org/gene/61853:LOC100606871 ^@ http://purl.uniprot.org/uniprot/A0A2I3H7Y1 ^@ Similarity ^@ Belongs to the strictosidine synthase family. http://togogenome.org/gene/61853:CADM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3FYE9|||http://purl.uniprot.org/uniprot/A0A2I3GYQ5|||http://purl.uniprot.org/uniprot/A0A2I3HGE9 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/61853:NPBWR2 ^@ http://purl.uniprot.org/uniprot/G1SBW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:SLC6A6 ^@ http://purl.uniprot.org/uniprot/A0A2I3FZC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:PTPRZ1 ^@ http://purl.uniprot.org/uniprot/G1RMS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.|||Membrane http://togogenome.org/gene/61853:CAP2 ^@ http://purl.uniprot.org/uniprot/G1QK71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:EBF2 ^@ http://purl.uniprot.org/uniprot/G1S2A8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/61853:TRNT1 ^@ http://purl.uniprot.org/uniprot/G1QSL5 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/61853:ST6GALNAC3 ^@ http://purl.uniprot.org/uniprot/A0A2I3FZP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/61853:TDGF1 ^@ http://purl.uniprot.org/uniprot/G1R2M8 ^@ Caution|||Similarity ^@ Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:PIGG ^@ http://purl.uniprot.org/uniprot/A0A2I3HGW0|||http://purl.uniprot.org/uniprot/G1QJB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:OPN1MW ^@ http://purl.uniprot.org/uniprot/G1RU23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/61853:INCENP ^@ http://purl.uniprot.org/uniprot/A0A2I3HV30|||http://purl.uniprot.org/uniprot/G1QTB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INCENP family.|||Midbody|||Nucleus|||kinetochore|||spindle http://togogenome.org/gene/61853:POLR3F ^@ http://purl.uniprot.org/uniprot/G1RFC5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/61853:LOC100587604 ^@ http://purl.uniprot.org/uniprot/M3ZBN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/61853:PON3 ^@ http://purl.uniprot.org/uniprot/G1S0T5 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated. http://togogenome.org/gene/61853:B3GALT1 ^@ http://purl.uniprot.org/uniprot/G1SBH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:PPP1CB ^@ http://purl.uniprot.org/uniprot/G1RZE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||nucleolus|||nucleoplasm http://togogenome.org/gene/61853:SNRPF ^@ http://purl.uniprot.org/uniprot/G1R1J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/61853:ST8SIA1 ^@ http://purl.uniprot.org/uniprot/G1QYM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/61853:TTC9B ^@ http://purl.uniprot.org/uniprot/G1RV94 ^@ Similarity ^@ Belongs to the TTC9 family. http://togogenome.org/gene/61853:WNT11 ^@ http://purl.uniprot.org/uniprot/G1S4M0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/61853:TNNI3 ^@ http://purl.uniprot.org/uniprot/G1RIW9 ^@ Function|||Similarity ^@ Belongs to the troponin I family.|||Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/61853:LOC100602571 ^@ http://purl.uniprot.org/uniprot/G1SCB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:LOC100585654 ^@ http://purl.uniprot.org/uniprot/G1S983 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:AGTR2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GVK7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MTUS1.|||Membrane http://togogenome.org/gene/61853:FBXL5 ^@ http://purl.uniprot.org/uniprot/G1S2Z0 ^@ Subcellular Location Annotation ^@ perinuclear region http://togogenome.org/gene/61853:KIF20A ^@ http://purl.uniprot.org/uniprot/A0A2I3HLT5|||http://purl.uniprot.org/uniprot/G1RBX2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/61853:SMAD2 ^@ http://purl.uniprot.org/uniprot/G1RL59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:PIANP ^@ http://purl.uniprot.org/uniprot/A0A2I3H1T8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:RPL10L ^@ http://purl.uniprot.org/uniprot/G1SAZ8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/61853:MRPL23 ^@ http://purl.uniprot.org/uniprot/M3ZB80 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/61853:LOC105739662 ^@ http://purl.uniprot.org/uniprot/A0A2I3G397 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/61853:GHSR ^@ http://purl.uniprot.org/uniprot/G1R0I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:CDC14B ^@ http://purl.uniprot.org/uniprot/G1S4K0 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. http://togogenome.org/gene/61853:DKK1 ^@ http://purl.uniprot.org/uniprot/G1RMY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/61853:PFDN2 ^@ http://purl.uniprot.org/uniprot/G1RUR1 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/61853:RSPO2 ^@ http://purl.uniprot.org/uniprot/G1QVK2 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/61853:INTS10 ^@ http://purl.uniprot.org/uniprot/G1QSW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 10 family.|||Nucleus http://togogenome.org/gene/61853:DBX2 ^@ http://purl.uniprot.org/uniprot/G1S8D6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:KCNAB3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HPR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cytoplasm http://togogenome.org/gene/61853:ADAMTS6 ^@ http://purl.uniprot.org/uniprot/G1QT93 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/61853:SIRT5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GHD2 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sirtuin family. Class III subfamily.|||Binds 1 zinc ion per subunit.|||In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind to malonylated and succinylated substrates and define the specificity.|||Mitochondrion|||Monomer. Homodimer. Interacts with CPS1.|||NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox.|||Nucleus|||cytosol http://togogenome.org/gene/61853:RBBP5 ^@ http://purl.uniprot.org/uniprot/A0A2I3G836 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:LOC100605034 ^@ http://purl.uniprot.org/uniprot/A0A2I3H5G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:CHST3 ^@ http://purl.uniprot.org/uniprot/G1S2X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/61853:VCAM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H0L6|||http://purl.uniprot.org/uniprot/G1RMJ1 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/61853:TMEM256 ^@ http://purl.uniprot.org/uniprot/A0A2I3HHC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM256 family.|||Membrane http://togogenome.org/gene/61853:RNF185 ^@ http://purl.uniprot.org/uniprot/G1QWA2 ^@ Domain|||Function|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase.|||Endoplasmic reticulum membrane|||Mitochondrion membrane|||The RING-type zinc finger domain is responsible for E3 ligase activity. http://togogenome.org/gene/61853:LOC100597620 ^@ http://purl.uniprot.org/uniprot/A0A7R8C309 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/61853:LOC100602900 ^@ http://purl.uniprot.org/uniprot/A0A2I3H7U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:KCNE4 ^@ http://purl.uniprot.org/uniprot/A0A2I3G959 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/61853:MTMR11 ^@ http://purl.uniprot.org/uniprot/G1RF23 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/61853:MRPL50 ^@ http://purl.uniprot.org/uniprot/G1S5I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL50 family.|||Mitochondrion http://togogenome.org/gene/61853:UBE2L6 ^@ http://purl.uniprot.org/uniprot/A0A2I3GB03 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/61853:CPLX2 ^@ http://purl.uniprot.org/uniprot/G1QID6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/61853:SYNDIG1 ^@ http://purl.uniprot.org/uniprot/G1S000 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/61853:S100G ^@ http://purl.uniprot.org/uniprot/G1REG0 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/61853:IPO9 ^@ http://purl.uniprot.org/uniprot/G1S8Y1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:TNFRSF11B ^@ http://purl.uniprot.org/uniprot/G1QYA0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:MTF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G3M5|||http://purl.uniprot.org/uniprot/G1RI07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/61853:SAA1 ^@ http://purl.uniprot.org/uniprot/G1S7R2 ^@ Function|||Similarity ^@ Belongs to the SAA family.|||Major acute phase reactant. Apolipoprotein of the HDL complex. http://togogenome.org/gene/61853:QRFPR ^@ http://purl.uniprot.org/uniprot/A0A2I3GEB5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:PTN ^@ http://purl.uniprot.org/uniprot/G1RTF8 ^@ Similarity ^@ Belongs to the pleiotrophin family. http://togogenome.org/gene/61853:HTR5A ^@ http://purl.uniprot.org/uniprot/A0A2I3GB88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:PEX14 ^@ http://purl.uniprot.org/uniprot/G1REA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-14 family.|||Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.|||Peroxisome membrane http://togogenome.org/gene/61853:FAM171B ^@ http://purl.uniprot.org/uniprot/G1R3X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM171 family.|||Membrane http://togogenome.org/gene/61853:RPP14 ^@ http://purl.uniprot.org/uniprot/A0A2I3HM53 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family. http://togogenome.org/gene/61853:BCL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GZF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion outer membrane|||Nucleus membrane http://togogenome.org/gene/61853:TRH ^@ http://purl.uniprot.org/uniprot/G1QZG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRH family.|||Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.|||Secreted http://togogenome.org/gene/61853:GDI2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GNY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/61853:SLC28A2 ^@ http://purl.uniprot.org/uniprot/G1R1L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/61853:CTNNAL1 ^@ http://purl.uniprot.org/uniprot/G1S6K3 ^@ Similarity ^@ Belongs to the vinculin/alpha-catenin family. http://togogenome.org/gene/61853:ACOX2 ^@ http://purl.uniprot.org/uniprot/G1R6V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/61853:HDHD2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HXK0 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/61853:TAS2R39 ^@ http://purl.uniprot.org/uniprot/G1S9X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/61853:GANAB ^@ http://purl.uniprot.org/uniprot/A0A2I3FUP5|||http://purl.uniprot.org/uniprot/G1QV88 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/61853:KCNJ6 ^@ http://purl.uniprot.org/uniprot/A0A2I3HQ04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.|||Membrane http://togogenome.org/gene/61853:MRPS10 ^@ http://purl.uniprot.org/uniprot/A0A2I3G6Q1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS10 family.|||Mitochondrion http://togogenome.org/gene/61853:ERCC5 ^@ http://purl.uniprot.org/uniprot/G1R8Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.|||Nucleus http://togogenome.org/gene/61853:NRCAM ^@ http://purl.uniprot.org/uniprot/A0A2I3GK07|||http://purl.uniprot.org/uniprot/A0A2I3HHY8|||http://purl.uniprot.org/uniprot/A0A2I3HN97|||http://purl.uniprot.org/uniprot/G1RAG9 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. http://togogenome.org/gene/61853:COPB1 ^@ http://purl.uniprot.org/uniprot/G1S7J6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Endoplasmic reticulum-Golgi intermediate compartment|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/61853:TOPAZ1 ^@ http://purl.uniprot.org/uniprot/G1R1V8 ^@ Function ^@ Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear. http://togogenome.org/gene/61853:KRR1 ^@ http://purl.uniprot.org/uniprot/G1QXI8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KRR1 family.|||Component of the ribosomal small subunit (SSU) processome.|||Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.|||nucleolus http://togogenome.org/gene/61853:POSTN ^@ http://purl.uniprot.org/uniprot/A0A2I3G6X1|||http://purl.uniprot.org/uniprot/A0A2I3GS27|||http://purl.uniprot.org/uniprot/A0A2I3HCB7|||http://purl.uniprot.org/uniprot/A0A2I3HM67|||http://purl.uniprot.org/uniprot/G1QPI1 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/61853:SPDYE4 ^@ http://purl.uniprot.org/uniprot/G1RG73 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/61853:TMEM170A ^@ http://purl.uniprot.org/uniprot/G1RRF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/61853:SLC5A8 ^@ http://purl.uniprot.org/uniprot/G1R2Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:TPM2 ^@ http://purl.uniprot.org/uniprot/G1QWA1|||http://purl.uniprot.org/uniprot/M3ZA73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/61853:TMEM47 ^@ http://purl.uniprot.org/uniprot/G1QHP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/61853:MYF5 ^@ http://purl.uniprot.org/uniprot/G1QZC6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/61853:ERBIN ^@ http://purl.uniprot.org/uniprot/A0A2I3GR05|||http://purl.uniprot.org/uniprot/A0A2I3HRK2|||http://purl.uniprot.org/uniprot/G1QUH5 ^@ Similarity ^@ Belongs to the LAP (LRR and PDZ) protein family. http://togogenome.org/gene/61853:CASP9 ^@ http://purl.uniprot.org/uniprot/A0A2I3GAX9 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/61853:TSHZ1 ^@ http://purl.uniprot.org/uniprot/G1SA11 ^@ Similarity ^@ Belongs to the teashirt C2H2-type zinc-finger protein family. http://togogenome.org/gene/61853:SNX21 ^@ http://purl.uniprot.org/uniprot/A0A2I3GIE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Membrane http://togogenome.org/gene/61853:FHL5 ^@ http://purl.uniprot.org/uniprot/G1RT37 ^@ Function|||Subcellular Location Annotation ^@ May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.|||Nucleus http://togogenome.org/gene/61853:LOC100600937 ^@ http://purl.uniprot.org/uniprot/G1SA53 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/61853:MFAP5 ^@ http://purl.uniprot.org/uniprot/G1QNW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MFAP family.|||extracellular matrix http://togogenome.org/gene/61853:SLITRK6 ^@ http://purl.uniprot.org/uniprot/G1S398 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/61853:FABP7 ^@ http://purl.uniprot.org/uniprot/A0A2I3H4D4|||http://purl.uniprot.org/uniprot/G1RU59 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/61853:OSMR ^@ http://purl.uniprot.org/uniprot/G1S2U3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/61853:PSMB4 ^@ http://purl.uniprot.org/uniprot/G1RGU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Non-catalytic component of the proteasome.|||Nucleus http://togogenome.org/gene/61853:PTPRE ^@ http://purl.uniprot.org/uniprot/A0A2I3GK79|||http://purl.uniprot.org/uniprot/G1QL34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:ADPRH ^@ http://purl.uniprot.org/uniprot/G1QYJ4 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/61853:GTF2B ^@ http://purl.uniprot.org/uniprot/G1RGV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIB family.|||Nucleus http://togogenome.org/gene/61853:AGRP ^@ http://purl.uniprot.org/uniprot/G1QXQ3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:HBQ1 ^@ http://purl.uniprot.org/uniprot/G1R965 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/61853:SGCD ^@ http://purl.uniprot.org/uniprot/A0A2I3G2J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/61853:UCN ^@ http://purl.uniprot.org/uniprot/G1QSL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/61853:SMPDL3B ^@ http://purl.uniprot.org/uniprot/G1RF21 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) per subunit.|||Secreted http://togogenome.org/gene/61853:IMPACT ^@ http://purl.uniprot.org/uniprot/G1R485 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IMPACT family.|||Cytoplasm http://togogenome.org/gene/61853:WNT16 ^@ http://purl.uniprot.org/uniprot/A0A2I3GPV0|||http://purl.uniprot.org/uniprot/G1RMK0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/61853:NDUFB10 ^@ http://purl.uniprot.org/uniprot/G1RC64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.|||Belongs to the complex I NDUFB10 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:C15H11orf88 ^@ http://purl.uniprot.org/uniprot/G1R6M8 ^@ Similarity ^@ Belongs to the HOATZ family. http://togogenome.org/gene/61853:UBL3 ^@ http://purl.uniprot.org/uniprot/G1QIP1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:KCNC2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HKC4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:NEDD9 ^@ http://purl.uniprot.org/uniprot/G1QIS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/61853:CXCR5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GYG2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:ZNF330 ^@ http://purl.uniprot.org/uniprot/A0A2I3GNS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOA36 family.|||centromere|||nucleolus http://togogenome.org/gene/61853:F2RL2 ^@ http://purl.uniprot.org/uniprot/G1RPZ9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:ADGRV1 ^@ http://purl.uniprot.org/uniprot/G1RUC6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:C20H2orf76 ^@ http://purl.uniprot.org/uniprot/A0A2I3FT36 ^@ Similarity ^@ Belongs to the UPF0538 family. http://togogenome.org/gene/61853:VPS54 ^@ http://purl.uniprot.org/uniprot/G1RFP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS54 family.|||trans-Golgi network http://togogenome.org/gene/61853:AP1S1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HF23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Membrane|||clathrin-coated pit http://togogenome.org/gene/61853:FIP1L1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HRV1|||http://purl.uniprot.org/uniprot/G1R9Y8|||http://purl.uniprot.org/uniprot/M3Z9S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FIP1 family.|||Nucleus http://togogenome.org/gene/61853:TTC27 ^@ http://purl.uniprot.org/uniprot/G1S1A0 ^@ Similarity ^@ Belongs to the TTC27 family. http://togogenome.org/gene/61853:DCTD ^@ http://purl.uniprot.org/uniprot/A0A2I3GDI3 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/61853:EPHB6 ^@ http://purl.uniprot.org/uniprot/G1QQV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:GSTO2 ^@ http://purl.uniprot.org/uniprot/A0A2I3FYU4 ^@ Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). http://togogenome.org/gene/61853:FEN1 ^@ http://purl.uniprot.org/uniprot/G1QS65 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Mitochondrion|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.|||nucleolus|||nucleoplasm http://togogenome.org/gene/61853:KCNA10 ^@ http://purl.uniprot.org/uniprot/G1S9E3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:FAM32A ^@ http://purl.uniprot.org/uniprot/G1R067 ^@ Similarity ^@ Belongs to the FAM32 family. http://togogenome.org/gene/61853:ACSM3 ^@ http://purl.uniprot.org/uniprot/G1RP53 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/61853:PPP1R11 ^@ http://purl.uniprot.org/uniprot/G1QYF6 ^@ Subunit ^@ Interacts with TLR2 and UBE2D2. http://togogenome.org/gene/61853:TAF9B ^@ http://purl.uniprot.org/uniprot/G1QL43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family.|||Nucleus http://togogenome.org/gene/61853:BZW2 ^@ http://purl.uniprot.org/uniprot/G1S3D2 ^@ Similarity ^@ Belongs to the BZW family. http://togogenome.org/gene/61853:LOC100591004 ^@ http://purl.uniprot.org/uniprot/G1R673 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/61853:DEFB132 ^@ http://purl.uniprot.org/uniprot/G1REG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/61853:NIT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3FXW3 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/61853:ATP6V1G1 ^@ http://purl.uniprot.org/uniprot/G1S4K5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/61853:UXS1 ^@ http://purl.uniprot.org/uniprot/G1RIR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/61853:LOC100596642 ^@ http://purl.uniprot.org/uniprot/G1R7U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/61853:CMC2 ^@ http://purl.uniprot.org/uniprot/G1RHJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/61853:TXNRD1 ^@ http://purl.uniprot.org/uniprot/G1R475 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/61853:TRPM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H076|||http://purl.uniprot.org/uniprot/G1R7K4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:EXT2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:HIGD1C ^@ http://purl.uniprot.org/uniprot/G1S7W4 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/61853:ODF2L ^@ http://purl.uniprot.org/uniprot/G1RGK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ODF2 family.|||centrosome http://togogenome.org/gene/61853:IRX5 ^@ http://purl.uniprot.org/uniprot/G1QKF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/61853:LOC100584415 ^@ http://purl.uniprot.org/uniprot/G1QU61 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/61853:DBNDD1 ^@ http://purl.uniprot.org/uniprot/G1S1R9 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/61853:SMG5 ^@ http://purl.uniprot.org/uniprot/G1RPI6 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays a role in nonsense-mediated mRNA decay. http://togogenome.org/gene/61853:FBXO45 ^@ http://purl.uniprot.org/uniprot/G1QLR5 ^@ Similarity ^@ Belongs to the FBXO45/Fsn family. http://togogenome.org/gene/61853:ALG13 ^@ http://purl.uniprot.org/uniprot/A0A2I3G9S4|||http://purl.uniprot.org/uniprot/A0A2I3H3T1 ^@ Similarity ^@ Belongs to the glycosyltransferase 28 family. http://togogenome.org/gene/61853:DNASE2B ^@ http://purl.uniprot.org/uniprot/G1RFT9 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/61853:ASIC5 ^@ http://purl.uniprot.org/uniprot/G1R330 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/61853:TRUB2 ^@ http://purl.uniprot.org/uniprot/G1S716 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/61853:GALP ^@ http://purl.uniprot.org/uniprot/G1RIM4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the galanin family.|||Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.|||Secreted http://togogenome.org/gene/61853:TARDBP ^@ http://purl.uniprot.org/uniprot/A0A2I3G8J5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:CRB1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GQB3|||http://purl.uniprot.org/uniprot/G1S8V2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:TSC22D1 ^@ http://purl.uniprot.org/uniprot/G1QN91 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/61853:ZRANB1 ^@ http://purl.uniprot.org/uniprot/G1QIF2 ^@ Similarity ^@ Belongs to the peptidase C64 family. http://togogenome.org/gene/61853:GALNT14 ^@ http://purl.uniprot.org/uniprot/A0A2I3G5K2|||http://purl.uniprot.org/uniprot/G1S004 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:FAM122B ^@ http://purl.uniprot.org/uniprot/A0A2I3H8A5 ^@ Similarity ^@ Belongs to the FAM122 family. http://togogenome.org/gene/61853:CTSO ^@ http://purl.uniprot.org/uniprot/A0A2I3H0E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/61853:IZUMO1R ^@ http://purl.uniprot.org/uniprot/G1R639 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/61853:VAMP4 ^@ http://purl.uniprot.org/uniprot/G1RYX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/61853:MED4 ^@ http://purl.uniprot.org/uniprot/G1QRT0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 4 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/61853:TDO2 ^@ http://purl.uniprot.org/uniprot/G1R355 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the tryptophan 2,3-dioxygenase family.|||Binds 1 heme group per subunit.|||Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.|||Homotetramer. Dimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:LIMK2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GXP6|||http://purl.uniprot.org/uniprot/A0A2I3HL37 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/61853:PRORP ^@ http://purl.uniprot.org/uniprot/M3ZAS6 ^@ Similarity ^@ Belongs to the PPR family. P subfamily. http://togogenome.org/gene/61853:LOC100604848 ^@ http://purl.uniprot.org/uniprot/G1S9K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:PAIP2 ^@ http://purl.uniprot.org/uniprot/G1RD29 ^@ Similarity ^@ Belongs to the PAIP2 family. http://togogenome.org/gene/61853:CAPN14 ^@ http://purl.uniprot.org/uniprot/G1S025 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/61853:S100PBP ^@ http://purl.uniprot.org/uniprot/A0A2I3GKU9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:PMS1 ^@ http://purl.uniprot.org/uniprot/G1R4F4 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/61853:SSBP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HNI0|||http://purl.uniprot.org/uniprot/G1RRV5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:SLC30A8 ^@ http://purl.uniprot.org/uniprot/A0A2I3H8R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/61853:POMGNT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GF52 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Membrane|||Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.|||The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.|||The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein. http://togogenome.org/gene/61853:LGSN ^@ http://purl.uniprot.org/uniprot/A0A2I3G9V3|||http://purl.uniprot.org/uniprot/A0A2I3HGC7 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/61853:STAM ^@ http://purl.uniprot.org/uniprot/A0A2I3HS36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane|||Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. http://togogenome.org/gene/61853:FRK ^@ http://purl.uniprot.org/uniprot/G1RRJ9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/61853:C10H19orf53 ^@ http://purl.uniprot.org/uniprot/G1RRR4 ^@ Function|||Similarity ^@ Belongs to the UPF0390 family.|||May have a potential role in hypercalcemia of malignancy. http://togogenome.org/gene/61853:TMPRSS11F ^@ http://purl.uniprot.org/uniprot/G1RD96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/61853:FITM1 ^@ http://purl.uniprot.org/uniprot/G1RZ12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIT family. FIT1 subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol. http://togogenome.org/gene/61853:PYCR3 ^@ http://purl.uniprot.org/uniprot/G1QNA2 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/61853:DPYSL2 ^@ http://purl.uniprot.org/uniprot/G1S2J3 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/61853:CLTA ^@ http://purl.uniprot.org/uniprot/A0A2I3GS47|||http://purl.uniprot.org/uniprot/A0A2I3GXD2|||http://purl.uniprot.org/uniprot/A0A2I3H7X0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/61853:HADHA ^@ http://purl.uniprot.org/uniprot/G1QMB6 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/61853:CPNE8 ^@ http://purl.uniprot.org/uniprot/A0A2I3HW93 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/61853:FYN ^@ http://purl.uniprot.org/uniprot/A0A2I3GI58|||http://purl.uniprot.org/uniprot/A0A2I3HC72 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/61853:ATP5MD ^@ http://purl.uniprot.org/uniprot/A0A2I3HEJ6 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion membrane http://togogenome.org/gene/61853:RDH11 ^@ http://purl.uniprot.org/uniprot/G1QJA6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/61853:TMEM116 ^@ http://purl.uniprot.org/uniprot/G1QGK6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:INMT ^@ http://purl.uniprot.org/uniprot/G1RYW1 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. http://togogenome.org/gene/61853:TAS2R40 ^@ http://purl.uniprot.org/uniprot/G1S9X9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/61853:NADK2 ^@ http://purl.uniprot.org/uniprot/G1S1U4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAD kinase family.|||Homodimer.|||Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.|||Mitochondrion http://togogenome.org/gene/61853:ZDHHC4 ^@ http://purl.uniprot.org/uniprot/G1S0D5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/61853:VPS13A ^@ http://purl.uniprot.org/uniprot/A0A2I3GA42|||http://purl.uniprot.org/uniprot/A0A2I3H2P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS13 family.|||Lipid droplet http://togogenome.org/gene/61853:DNAJA2 ^@ http://purl.uniprot.org/uniprot/G1S0P3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:SERPINI1 ^@ http://purl.uniprot.org/uniprot/G1QYD3 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/61853:CXXC1 ^@ http://purl.uniprot.org/uniprot/G1RM78 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:ZKSCAN8 ^@ http://purl.uniprot.org/uniprot/A0A2I3HWF0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:SLCO1A2 ^@ http://purl.uniprot.org/uniprot/G1QXW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:ST8SIA2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GH03|||http://purl.uniprot.org/uniprot/G1RP15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/61853:PROZ ^@ http://purl.uniprot.org/uniprot/G1QI89 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:FSHR ^@ http://purl.uniprot.org/uniprot/A0A2I3HAG1|||http://purl.uniprot.org/uniprot/G1RC06 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.|||Membrane http://togogenome.org/gene/61853:RET ^@ http://purl.uniprot.org/uniprot/G1S142 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane|||Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. http://togogenome.org/gene/61853:RSBN1 ^@ http://purl.uniprot.org/uniprot/G1QWQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the round spermatid basic protein 1 family.|||Nucleus http://togogenome.org/gene/61853:LOC100581904 ^@ http://purl.uniprot.org/uniprot/G1RCK8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:FLT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HPF9|||http://purl.uniprot.org/uniprot/G1QIB2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Forms a complex composed of PDGFRL, TNK2 and GRB2.|||Membrane http://togogenome.org/gene/61853:SLBP ^@ http://purl.uniprot.org/uniprot/A0A2I3HBW8 ^@ Similarity ^@ Belongs to the SLBP family. http://togogenome.org/gene/61853:ATP6AP1 ^@ http://purl.uniprot.org/uniprot/G1RVI5 ^@ Similarity ^@ Belongs to the vacuolar ATPase subunit S1 family. http://togogenome.org/gene/61853:GDF6 ^@ http://purl.uniprot.org/uniprot/G1QTN7 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/61853:MRPL41 ^@ http://purl.uniprot.org/uniprot/G1RDE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL41 family.|||Mitochondrion http://togogenome.org/gene/61853:BACE1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Endosome|||Membrane|||Membrane raft|||Recycling endosome|||trans-Golgi network http://togogenome.org/gene/61853:POU4F2 ^@ http://purl.uniprot.org/uniprot/G1R0S6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/61853:ARSB ^@ http://purl.uniprot.org/uniprot/G1RQM3 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/61853:RNF34 ^@ http://purl.uniprot.org/uniprot/A0A2I3G8S9|||http://purl.uniprot.org/uniprot/A0A2I3GZD9 ^@ Subcellular Location Annotation ^@ Cell membrane|||cytosol http://togogenome.org/gene/61853:SLC25A38 ^@ http://purl.uniprot.org/uniprot/G1R0S9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.|||Membrane|||Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.|||Mitochondrion inner membrane|||Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis. http://togogenome.org/gene/61853:NODAL ^@ http://purl.uniprot.org/uniprot/G1S215 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/61853:SBDS ^@ http://purl.uniprot.org/uniprot/G1RSB1 ^@ Function|||Similarity ^@ Belongs to the SDO1/SBDS family.|||Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. http://togogenome.org/gene/61853:F13B ^@ http://purl.uniprot.org/uniprot/G1S8U8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:ADAMDEC1 ^@ http://purl.uniprot.org/uniprot/G1S1N5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:SNX31 ^@ http://purl.uniprot.org/uniprot/G1QS75 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/61853:GABPA ^@ http://purl.uniprot.org/uniprot/G1QQ27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/61853:TXLNG ^@ http://purl.uniprot.org/uniprot/G1REH4 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/61853:TANGO6 ^@ http://purl.uniprot.org/uniprot/G1R018 ^@ Similarity ^@ Belongs to the Tango6 family. http://togogenome.org/gene/61853:RNF141 ^@ http://purl.uniprot.org/uniprot/G1S770 ^@ Function ^@ May be involved in spermatogenesis. http://togogenome.org/gene/61853:LOC100600266 ^@ http://purl.uniprot.org/uniprot/A0A2I3GM88 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/61853:UBE2H ^@ http://purl.uniprot.org/uniprot/G1RQ84 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/61853:PF4V1 ^@ http://purl.uniprot.org/uniprot/G1R8X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/61853:LOC100587339 ^@ http://purl.uniprot.org/uniprot/G1QS81 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:AQP9 ^@ http://purl.uniprot.org/uniprot/G1RKK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/61853:SMPD3 ^@ http://purl.uniprot.org/uniprot/G1QZM0 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/61853:ACP5 ^@ http://purl.uniprot.org/uniprot/G1RQ24 ^@ Cofactor ^@ Binds 2 iron ions per subunit. http://togogenome.org/gene/61853:FABP3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GZJ2 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/61853:LOC100605912 ^@ http://purl.uniprot.org/uniprot/G1R5B0|||http://purl.uniprot.org/uniprot/G1SAF6 ^@ Similarity ^@ Belongs to the GroES chaperonin family.|||Belongs to the MOB1/phocein family. http://togogenome.org/gene/61853:ALG5 ^@ http://purl.uniprot.org/uniprot/G1QMA9 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/61853:TMCC1 ^@ http://purl.uniprot.org/uniprot/G1QZH9 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/61853:UBA6 ^@ http://purl.uniprot.org/uniprot/G1RD44 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/61853:MEIS2 ^@ http://purl.uniprot.org/uniprot/A0A2I3I028|||http://purl.uniprot.org/uniprot/G1RKN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/61853:BORCS7 ^@ http://purl.uniprot.org/uniprot/A0A2I3GZG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS7 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/61853:ADTRP ^@ http://purl.uniprot.org/uniprot/A0A2I3GUP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane http://togogenome.org/gene/61853:LOC100579421 ^@ http://purl.uniprot.org/uniprot/G1S977 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:MUSTN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H301 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MUSTANG family.|||Nucleus http://togogenome.org/gene/61853:AMD1 ^@ http://purl.uniprot.org/uniprot/G1RQS4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic AdoMetDC family.|||Binds 1 pyruvoyl group covalently per subunit.|||Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.|||Heterotetramer of two alpha and two beta chains. http://togogenome.org/gene/61853:TMA16 ^@ http://purl.uniprot.org/uniprot/A0A2I3HP04 ^@ Function|||Similarity|||Subunit ^@ Associates with pre-60S ribosomal particles.|||Belongs to the TMA16 family.|||Involved in the biogenesis of the 60S ribosomal subunit in the nucleus. http://togogenome.org/gene/61853:EPHA2 ^@ http://purl.uniprot.org/uniprot/G1R858 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:GPX7 ^@ http://purl.uniprot.org/uniprot/G1S8M6 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/61853:EEF1A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HHP9 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/61853:NF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3FXA5|||http://purl.uniprot.org/uniprot/G1QT29 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/61853:SMCO2 ^@ http://purl.uniprot.org/uniprot/G1R0D8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:INTS13 ^@ http://purl.uniprot.org/uniprot/G1R014 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the asunder family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:AKAP12 ^@ http://purl.uniprot.org/uniprot/A0A2I3GLF0|||http://purl.uniprot.org/uniprot/G1RZJ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:HPGD ^@ http://purl.uniprot.org/uniprot/G1R4P1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/61853:SULT1E1 ^@ http://purl.uniprot.org/uniprot/G1R7X4 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/61853:LCE2D ^@ http://purl.uniprot.org/uniprot/G1RH93 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/61853:NDUFB6 ^@ http://purl.uniprot.org/uniprot/G1QZX4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB6 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:UBE2L5 ^@ http://purl.uniprot.org/uniprot/G1SAJ3 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/61853:UTP14A ^@ http://purl.uniprot.org/uniprot/G1RZ56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP14 family.|||nucleolus http://togogenome.org/gene/61853:ACAD8 ^@ http://purl.uniprot.org/uniprot/G1RPQ0 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/61853:REEP4 ^@ http://purl.uniprot.org/uniprot/M3ZB55 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:RCAN3 ^@ http://purl.uniprot.org/uniprot/G1RCG5 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/61853:ROS1 ^@ http://purl.uniprot.org/uniprot/G1RSK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/61853:FOXI3 ^@ http://purl.uniprot.org/uniprot/G1QRU0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:EMC4 ^@ http://purl.uniprot.org/uniprot/A0A2I3FZA3|||http://purl.uniprot.org/uniprot/G1RIX2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC4 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:RBM8A ^@ http://purl.uniprot.org/uniprot/A0A2I3I026 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBM8A family.|||Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.|||Cytoplasm|||Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.|||Nucleus|||Nucleus speckle http://togogenome.org/gene/61853:DDX56 ^@ http://purl.uniprot.org/uniprot/G1QUW1 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/61853:RBL1 ^@ http://purl.uniprot.org/uniprot/G1R2W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the retinoblastoma protein (RB) family.|||Nucleus http://togogenome.org/gene/61853:HCST ^@ http://purl.uniprot.org/uniprot/G1RLI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAP10 family.|||Membrane http://togogenome.org/gene/61853:SV2B ^@ http://purl.uniprot.org/uniprot/G1RNZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/61853:PIAS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HR02 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/61853:USP16 ^@ http://purl.uniprot.org/uniprot/G1QSD9 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C19 family. USP16 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Homotetramer.|||Nucleus|||Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.|||Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.|||The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin. http://togogenome.org/gene/61853:HHIP ^@ http://purl.uniprot.org/uniprot/G1R071 ^@ Caution|||Similarity ^@ Belongs to the HHIP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:ARHGEF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HHZ2 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Golgi apparatus|||Vesicle|||spindle|||tight junction http://togogenome.org/gene/61853:CBR1 ^@ http://purl.uniprot.org/uniprot/G1QWG6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/61853:HAO1 ^@ http://purl.uniprot.org/uniprot/G1RV60 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/61853:ADCY8 ^@ http://purl.uniprot.org/uniprot/G1R0Z0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/61853:HAPLN4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GKZ5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:SLC45A1 ^@ http://purl.uniprot.org/uniprot/G1RC02 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:MRPS24 ^@ http://purl.uniprot.org/uniprot/A0A2I3HIE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Mitochondrion http://togogenome.org/gene/61853:MACO1 ^@ http://purl.uniprot.org/uniprot/G1RCW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the macoilin family.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane|||Plays a role in the regulation of neuronal activity.|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/61853:THEMIS ^@ http://purl.uniprot.org/uniprot/G1RVG2 ^@ Similarity ^@ Belongs to the themis family. http://togogenome.org/gene/61853:MRPL19 ^@ http://purl.uniprot.org/uniprot/G1QKB4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family. http://togogenome.org/gene/61853:PNN ^@ http://purl.uniprot.org/uniprot/G1QVI0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pinin family.|||Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.|||Nucleus speckle|||desmosome http://togogenome.org/gene/61853:S100A2 ^@ http://purl.uniprot.org/uniprot/G1RHG7 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/61853:TXK ^@ http://purl.uniprot.org/uniprot/G1S6F7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/61853:SATB2 ^@ http://purl.uniprot.org/uniprot/G1R5C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/61853:GART ^@ http://purl.uniprot.org/uniprot/G1QV60 ^@ Similarity ^@ In the C-terminal section; belongs to the GART family.|||In the N-terminal section; belongs to the GARS family.|||In the central section; belongs to the AIR synthase family. http://togogenome.org/gene/61853:CIAO2A ^@ http://purl.uniprot.org/uniprot/A0A2I3GWM9 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/61853:GLRA2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GR43|||http://purl.uniprot.org/uniprot/G1RDL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/61853:TBCE ^@ http://purl.uniprot.org/uniprot/A0A2I3HRZ7|||http://purl.uniprot.org/uniprot/G1QRK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCE family.|||Belongs to the eukaryotic ribosomal protein eS21 family.|||Cytoplasm http://togogenome.org/gene/61853:SEPTIN4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GAN4|||http://purl.uniprot.org/uniprot/A0A2I3HPY7|||http://purl.uniprot.org/uniprot/G1RA55 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/61853:SCN7A ^@ http://purl.uniprot.org/uniprot/G1QTL3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/61853:UBE2E3 ^@ http://purl.uniprot.org/uniprot/G1R373 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/61853:CPLX4 ^@ http://purl.uniprot.org/uniprot/G1RAE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/61853:P2RY1 ^@ http://purl.uniprot.org/uniprot/G1SBA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:DTX3 ^@ http://purl.uniprot.org/uniprot/G1S638 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/61853:SLCO6A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3FWQ0|||http://purl.uniprot.org/uniprot/A0A2I3H1X2|||http://purl.uniprot.org/uniprot/G1RJ49 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:MAP3K13 ^@ http://purl.uniprot.org/uniprot/G1R3U1 ^@ Function|||Similarity ^@ Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7.|||Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/61853:FAM13C ^@ http://purl.uniprot.org/uniprot/A0A2I3FYC9|||http://purl.uniprot.org/uniprot/A0A2I3GPG7 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/61853:TADA1 ^@ http://purl.uniprot.org/uniprot/G1RXH6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TADA1 family.|||Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.|||Nucleus|||Probably involved in transcriptional regulation. http://togogenome.org/gene/61853:PLA2G1B ^@ http://purl.uniprot.org/uniprot/G1S0C2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/61853:POU2F3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HPQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-2 subfamily.|||Nucleus http://togogenome.org/gene/61853:ZIC4 ^@ http://purl.uniprot.org/uniprot/G1QPN3 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/61853:LOC100586992 ^@ http://purl.uniprot.org/uniprot/A0A2I3HRJ3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:C6 ^@ http://purl.uniprot.org/uniprot/G1S3V9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complement C6/C7/C8/C9 family.|||Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.|||Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:CUL4A ^@ http://purl.uniprot.org/uniprot/G1QIW7 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/61853:TSPYL1 ^@ http://purl.uniprot.org/uniprot/G1SBV2 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/61853:LOC100586892 ^@ http://purl.uniprot.org/uniprot/G1S1L5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:RCAN2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBN8|||http://purl.uniprot.org/uniprot/G1QX80 ^@ Function|||Similarity ^@ Belongs to the RCAN family.|||Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. http://togogenome.org/gene/61853:STXBP3 ^@ http://purl.uniprot.org/uniprot/G1QN24 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/61853:LOC100582085 ^@ http://purl.uniprot.org/uniprot/G1S367 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/61853:MYO9A ^@ http://purl.uniprot.org/uniprot/G1RU69 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/61853:CSMD1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GDK1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:UBE2D3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HVI4 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/61853:CHAC1 ^@ http://purl.uniprot.org/uniprot/G1QTA1 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/61853:B4GALT6 ^@ http://purl.uniprot.org/uniprot/G1R3S5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/61853:DYNC1I2 ^@ http://purl.uniprot.org/uniprot/A0A2I3FRB4|||http://purl.uniprot.org/uniprot/A0A2I3GGY1 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/61853:FBXO48 ^@ http://purl.uniprot.org/uniprot/G1RG58 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.|||Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation. http://togogenome.org/gene/61853:MYOZ1 ^@ http://purl.uniprot.org/uniprot/G1S450 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/61853:PPDPFL ^@ http://purl.uniprot.org/uniprot/A0A2I3GD11 ^@ Similarity ^@ Belongs to the PPDPF family. http://togogenome.org/gene/61853:MGST1 ^@ http://purl.uniprot.org/uniprot/G1QW63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/61853:WDR76 ^@ http://purl.uniprot.org/uniprot/G1R0E3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the WD repeat DDB2/WDR76 family.|||Interacts with CUL4A and/or CUL4B.|||Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. http://togogenome.org/gene/61853:TCTE3 ^@ http://purl.uniprot.org/uniprot/G1QH97 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/61853:PHGDH ^@ http://purl.uniprot.org/uniprot/A0A2I3FZC7 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/61853:ESCO1 ^@ http://purl.uniprot.org/uniprot/G1R536 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:CTNNB1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HZB4|||http://purl.uniprot.org/uniprot/G1R1B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-catenin family.|||adherens junction http://togogenome.org/gene/61853:DPYD ^@ http://purl.uniprot.org/uniprot/G1RKT4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the dihydropyrimidine dehydrogenase family.|||Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.|||Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. http://togogenome.org/gene/61853:ESRRG ^@ http://purl.uniprot.org/uniprot/A0A2I3HQE9|||http://purl.uniprot.org/uniprot/G1RVM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/61853:CNOT1 ^@ http://purl.uniprot.org/uniprot/G1QUG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT1 family.|||Nucleus http://togogenome.org/gene/61853:CDH20 ^@ http://purl.uniprot.org/uniprot/G1RAV5 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:METTL3 ^@ http://purl.uniprot.org/uniprot/G1RWX6 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/61853:SSH2 ^@ http://purl.uniprot.org/uniprot/G1QTP5 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/61853:ASB7 ^@ http://purl.uniprot.org/uniprot/G1QJX0 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/61853:LOC105737502 ^@ http://purl.uniprot.org/uniprot/G1RED5 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/61853:IPO7 ^@ http://purl.uniprot.org/uniprot/G1S728 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:CASP2 ^@ http://purl.uniprot.org/uniprot/G1QSD1 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/61853:ITM2C ^@ http://purl.uniprot.org/uniprot/G1RUC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/61853:HOXD12 ^@ http://purl.uniprot.org/uniprot/G1R246 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:GATC ^@ http://purl.uniprot.org/uniprot/G1S0F5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/61853:SERPINB7 ^@ http://purl.uniprot.org/uniprot/A0A2I3GE21|||http://purl.uniprot.org/uniprot/G1RCD6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/61853:PLXNC1 ^@ http://purl.uniprot.org/uniprot/G1R179 ^@ Caution|||Similarity ^@ Belongs to the plexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:CPA5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GYV0|||http://purl.uniprot.org/uniprot/G1RQM4 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/61853:LOC100601292 ^@ http://purl.uniprot.org/uniprot/G1SC63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/61853:ASPM ^@ http://purl.uniprot.org/uniprot/A0A2I3GN13 ^@ Subcellular Location Annotation ^@ Nucleus|||spindle http://togogenome.org/gene/61853:MRPS18C ^@ http://purl.uniprot.org/uniprot/A0A2I3GX69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Mitochondrion http://togogenome.org/gene/61853:GJA4 ^@ http://purl.uniprot.org/uniprot/A0A654IDH3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/61853:KRT73 ^@ http://purl.uniprot.org/uniprot/G1S7P9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/61853:NR2F2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HRX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/61853:ACTN3 ^@ http://purl.uniprot.org/uniprot/G1R2R8 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/61853:NKX2-8 ^@ http://purl.uniprot.org/uniprot/G1QUX2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:PLAT ^@ http://purl.uniprot.org/uniprot/A0A2I3GC18 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:PRNP ^@ http://purl.uniprot.org/uniprot/A0A2I3FRC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prion family.|||Cell membrane|||Golgi apparatus|||Membrane http://togogenome.org/gene/61853:PPT2 ^@ http://purl.uniprot.org/uniprot/G1R488 ^@ Similarity ^@ Belongs to the palmitoyl-protein thioesterase family. http://togogenome.org/gene/61853:FOLR3 ^@ http://purl.uniprot.org/uniprot/G1S5Y4 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/61853:DOLPP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GV95|||http://purl.uniprot.org/uniprot/G1S7B9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dolichyldiphosphatase family.|||Endoplasmic reticulum membrane|||Membrane|||Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. http://togogenome.org/gene/61853:SEC22A ^@ http://purl.uniprot.org/uniprot/G1QHL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/61853:STAMBP ^@ http://purl.uniprot.org/uniprot/G1QHI7 ^@ Similarity ^@ Belongs to the peptidase M67C family. http://togogenome.org/gene/61853:GGPS1 ^@ http://purl.uniprot.org/uniprot/G1QR51 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/61853:FAM168A ^@ http://purl.uniprot.org/uniprot/A0A2I3GVF0|||http://purl.uniprot.org/uniprot/A0A2I3HG04 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/61853:CASP8 ^@ http://purl.uniprot.org/uniprot/A0A2I3GJU5 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/61853:MTERF3 ^@ http://purl.uniprot.org/uniprot/G1QTT7 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/61853:ADORA3 ^@ http://purl.uniprot.org/uniprot/A0A2I3G080|||http://purl.uniprot.org/uniprot/A0A2I3GKD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/61853:AMACR ^@ http://purl.uniprot.org/uniprot/A0A2I3I058|||http://purl.uniprot.org/uniprot/G1RVY1 ^@ Similarity ^@ Belongs to the CoA-transferase III family. http://togogenome.org/gene/61853:ACTN4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GQL4|||http://purl.uniprot.org/uniprot/G1S4J1 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/61853:GNMT ^@ http://purl.uniprot.org/uniprot/A0A2I3HXZ4 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. http://togogenome.org/gene/61853:TMEM218 ^@ http://purl.uniprot.org/uniprot/A0A2I3HHG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM218 family.|||May be involved in ciliary biogenesis or function.|||Membrane|||cilium http://togogenome.org/gene/61853:GALNTL6 ^@ http://purl.uniprot.org/uniprot/A0A2I3HSY4|||http://purl.uniprot.org/uniprot/G1R4G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:HMGCS2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HU63 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/61853:ZDHHC13 ^@ http://purl.uniprot.org/uniprot/G1S7X6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/61853:HLF ^@ http://purl.uniprot.org/uniprot/G1R959 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/61853:SEC61B ^@ http://purl.uniprot.org/uniprot/G1S5C4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Endoplasmic reticulum membrane|||Membrane|||Necessary for protein translocation in the endoplasmic reticulum. http://togogenome.org/gene/61853:DSG4 ^@ http://purl.uniprot.org/uniprot/A0A2I3H3N0|||http://purl.uniprot.org/uniprot/G1R3Y0 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/61853:ACVRL1 ^@ http://purl.uniprot.org/uniprot/G1S7T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/61853:ITGA1 ^@ http://purl.uniprot.org/uniprot/G1RJ15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/61853:IL18 ^@ http://purl.uniprot.org/uniprot/A0A2I3H411 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Cytoplasm|||Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted http://togogenome.org/gene/61853:RAG2 ^@ http://purl.uniprot.org/uniprot/G1S8G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAG2 family.|||Nucleus http://togogenome.org/gene/61853:CSN2 ^@ http://purl.uniprot.org/uniprot/G1R7Y4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-casein family.|||Important role in determination of the surface properties of the casein micelles.|||Secreted http://togogenome.org/gene/61853:AK6 ^@ http://purl.uniprot.org/uniprot/A0A2I3HKT6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.|||Cajal body|||Monomer and homodimer. Interacts with COIL (via C-terminus).|||nucleoplasm http://togogenome.org/gene/61853:CD38 ^@ http://purl.uniprot.org/uniprot/A0A2I3G9I1 ^@ Similarity ^@ Belongs to the ADP-ribosyl cyclase family. http://togogenome.org/gene/61853:TMEM161B ^@ http://purl.uniprot.org/uniprot/A0A2I3HEP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM161 family.|||Membrane http://togogenome.org/gene/61853:WAS ^@ http://purl.uniprot.org/uniprot/G1R8P1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:GBE1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GDY3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. http://togogenome.org/gene/61853:LTB ^@ http://purl.uniprot.org/uniprot/A0A0U5CJC9|||http://purl.uniprot.org/uniprot/G1R2L2 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/61853:RNF5 ^@ http://purl.uniprot.org/uniprot/A0A2I3H4E1 ^@ Domain|||Function|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase.|||Endoplasmic reticulum membrane|||Mitochondrion membrane|||The RING-type zinc finger domain is responsible for E3 ligase activity. http://togogenome.org/gene/61853:OSBP ^@ http://purl.uniprot.org/uniprot/G1RRK0 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/61853:NTRK2 ^@ http://purl.uniprot.org/uniprot/G1QU92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/61853:PPP4C ^@ http://purl.uniprot.org/uniprot/G1QNR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/61853:ESD ^@ http://purl.uniprot.org/uniprot/G1QRI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the esterase D family.|||Cytoplasmic vesicle|||Serine hydrolase involved in the detoxification of formaldehyde. http://togogenome.org/gene/61853:ZNF706 ^@ http://purl.uniprot.org/uniprot/G1QSM9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/61853:SERPINB9 ^@ http://purl.uniprot.org/uniprot/A0A2I3HQX0 ^@ Similarity ^@ Belongs to the serpin family. Ov-serpin subfamily. http://togogenome.org/gene/61853:ELAC1 ^@ http://purl.uniprot.org/uniprot/G1RME1 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/61853:ANAPC4 ^@ http://purl.uniprot.org/uniprot/G1S4N5 ^@ Function|||Similarity ^@ Belongs to the APC4 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/61853:OPRPN ^@ http://purl.uniprot.org/uniprot/G1R817 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/61853:PCYT1B ^@ http://purl.uniprot.org/uniprot/A0A2I3H1F8|||http://purl.uniprot.org/uniprot/A0A2I3HGH6 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/61853:SYNGR1 ^@ http://purl.uniprot.org/uniprot/G1RZ16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/61853:MRPS18B ^@ http://purl.uniprot.org/uniprot/G1QZE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.|||Mitochondrion http://togogenome.org/gene/61853:GABRB1 ^@ http://purl.uniprot.org/uniprot/G1S6A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/61853:FAM161A ^@ http://purl.uniprot.org/uniprot/A0A2I3HVZ5|||http://purl.uniprot.org/uniprot/G1RF22 ^@ Similarity ^@ Belongs to the FAM161 family. http://togogenome.org/gene/61853:PLA2G3 ^@ http://purl.uniprot.org/uniprot/G1QW45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Secreted http://togogenome.org/gene/61853:ANKRD13D ^@ http://purl.uniprot.org/uniprot/G1R3E1 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/61853:CMC1 ^@ http://purl.uniprot.org/uniprot/G1QVE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/61853:LOC100591514 ^@ http://purl.uniprot.org/uniprot/A0A2I3HKK9 ^@ Similarity ^@ Belongs to the PRORSD1 family. http://togogenome.org/gene/61853:EIF3D ^@ http://purl.uniprot.org/uniprot/G1RX45 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit D family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Cytoplasm|||Phosphorylated upon DNA damage, probably by ATM or ATR.|||The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.|||mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. http://togogenome.org/gene/61853:SDHAF1 ^@ http://purl.uniprot.org/uniprot/G1SB53 ^@ Similarity ^@ Belongs to the complex I LYR family. SDHAF1 subfamily. http://togogenome.org/gene/61853:PLXNA4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HNW6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:PTGDR2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HUA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:LSM3 ^@ http://purl.uniprot.org/uniprot/G1QYX9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/61853:OTULIN ^@ http://purl.uniprot.org/uniprot/G1RMD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C65 family. Otulin subfamily.|||Cytoplasm http://togogenome.org/gene/61853:PMP22 ^@ http://purl.uniprot.org/uniprot/G1RX87 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Might be involved in growth regulation, and in myelinization in the peripheral nervous system. http://togogenome.org/gene/61853:ZSCAN10 ^@ http://purl.uniprot.org/uniprot/G1REM6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:CBX3 ^@ http://purl.uniprot.org/uniprot/G1RY36 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:SPTSSA ^@ http://purl.uniprot.org/uniprot/A0A2I3GSY5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:AGTR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HHW9|||http://purl.uniprot.org/uniprot/G1QPQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. http://togogenome.org/gene/61853:NRP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HU08|||http://purl.uniprot.org/uniprot/G1R609 ^@ Caution|||Similarity ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:MRPL22 ^@ http://purl.uniprot.org/uniprot/A0A2I3GUV3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/61853:VGLL1 ^@ http://purl.uniprot.org/uniprot/G1QR45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs.|||Nucleus http://togogenome.org/gene/61853:TNF ^@ http://purl.uniprot.org/uniprot/A0A2I3HVV8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Cell membrane|||Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.|||Homotrimer. Interacts with SPPL2B.|||Membrane|||O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.|||Secreted|||The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.|||The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.|||The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space. http://togogenome.org/gene/61853:CRYAB ^@ http://purl.uniprot.org/uniprot/A0A2I3GIW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.|||Nucleus http://togogenome.org/gene/61853:DIO1 ^@ http://purl.uniprot.org/uniprot/G1QTE8 ^@ Function|||Similarity ^@ Belongs to the iodothyronine deiodinase family.|||Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine). http://togogenome.org/gene/61853:ZNF280B ^@ http://purl.uniprot.org/uniprot/G1SBM6 ^@ Function|||Subcellular Location Annotation ^@ May function as a transcription factor.|||Nucleus http://togogenome.org/gene/61853:ESR1 ^@ http://purl.uniprot.org/uniprot/G1RZN0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Binds DNA as a homodimer.|||Nucleus|||The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. http://togogenome.org/gene/61853:LOC100593944 ^@ http://purl.uniprot.org/uniprot/G1S7K4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/61853:RAP1GDS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G3E1|||http://purl.uniprot.org/uniprot/G1RV47 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Mitochondrion http://togogenome.org/gene/61853:EMG1 ^@ http://purl.uniprot.org/uniprot/G1QYY8 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. http://togogenome.org/gene/61853:MRAP ^@ http://purl.uniprot.org/uniprot/G1QU03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:APCS ^@ http://purl.uniprot.org/uniprot/G1RS30 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Secreted http://togogenome.org/gene/61853:CREB1 ^@ http://purl.uniprot.org/uniprot/G1R662|||http://purl.uniprot.org/uniprot/M3Z9R8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:VGLL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3H6S2|||http://purl.uniprot.org/uniprot/G1RS91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||Nucleus http://togogenome.org/gene/61853:MPP1 ^@ http://purl.uniprot.org/uniprot/G1RWA1 ^@ Function|||Subcellular Location Annotation ^@ Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.|||stereocilium http://togogenome.org/gene/61853:TIGD1 ^@ http://purl.uniprot.org/uniprot/G1S9M7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:LOC100583757 ^@ http://purl.uniprot.org/uniprot/G1QU07 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/61853:MCIDAS ^@ http://purl.uniprot.org/uniprot/G1QKK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the geminin family.|||Nucleus http://togogenome.org/gene/61853:PHTF1 ^@ http://purl.uniprot.org/uniprot/G1QWN1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:MCM3 ^@ http://purl.uniprot.org/uniprot/A0A2I3G1N9|||http://purl.uniprot.org/uniprot/G1QUQ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/61853:DYNC1I1 ^@ http://purl.uniprot.org/uniprot/G1S1E0 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/61853:SLC25A31 ^@ http://purl.uniprot.org/uniprot/G1RT90 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/61853:SF3B1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GPD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B1 family.|||Nucleus http://togogenome.org/gene/61853:TFCP2 ^@ http://purl.uniprot.org/uniprot/G1S7V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/61853:OLFM1 ^@ http://purl.uniprot.org/uniprot/G1RBX1 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/61853:MARK3 ^@ http://purl.uniprot.org/uniprot/A0A2I3H797|||http://purl.uniprot.org/uniprot/A0A2I3HZ00|||http://purl.uniprot.org/uniprot/G1S263 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/61853:NPAS4 ^@ http://purl.uniprot.org/uniprot/G1R2I3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:EPS8 ^@ http://purl.uniprot.org/uniprot/G1QVP9 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/61853:LOC100607684 ^@ http://purl.uniprot.org/uniprot/H9HA54 ^@ Similarity ^@ Belongs to the FAM76 family. http://togogenome.org/gene/61853:TIMP4 ^@ http://purl.uniprot.org/uniprot/G1QXF4 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/61853:DYDC2 ^@ http://purl.uniprot.org/uniprot/A0A2I3FVZ4|||http://purl.uniprot.org/uniprot/A0A2I3GTH9 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/61853:ADA ^@ http://purl.uniprot.org/uniprot/A0A2I3HZE9|||http://purl.uniprot.org/uniprot/G1R4E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Cell junction|||Cell membrane|||Cytoplasmic vesicle lumen http://togogenome.org/gene/61853:PYCARD ^@ http://purl.uniprot.org/uniprot/G1S2K3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Inflammasome http://togogenome.org/gene/61853:MT1E ^@ http://purl.uniprot.org/uniprot/G1QP40 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/61853:CYTB ^@ http://purl.uniprot.org/uniprot/E5DW44 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b family.|||Binds 2 heme groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.|||Membrane|||Mitochondrion inner membrane|||The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer. http://togogenome.org/gene/61853:IAPP ^@ http://purl.uniprot.org/uniprot/G1QXX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcitonin family.|||Secreted|||Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. http://togogenome.org/gene/61853:FIS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H8F2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIS1 family.|||Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.|||Membrane|||Mitochondrion outer membrane|||The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission. http://togogenome.org/gene/61853:SLC25A11 ^@ http://purl.uniprot.org/uniprot/A0A2I3GN19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/61853:TMEM9 ^@ http://purl.uniprot.org/uniprot/G1S8X1 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/61853:NSRP1 ^@ http://purl.uniprot.org/uniprot/G1QTX9 ^@ Similarity ^@ Belongs to the NSRP1 family. http://togogenome.org/gene/61853:NIF3L1 ^@ http://purl.uniprot.org/uniprot/G1R5I3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family.|||Cytoplasm|||Homodimer. Interacts with COPS2. Interacts with THOC7.|||May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.|||Nucleus http://togogenome.org/gene/61853:DCAF1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GCS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPRBP/DCAF1 family.|||Nucleus http://togogenome.org/gene/61853:GOT1 ^@ http://purl.uniprot.org/uniprot/G1RWW9 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/61853:GAD1 ^@ http://purl.uniprot.org/uniprot/G1QZH4 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/61853:LOC100605241 ^@ http://purl.uniprot.org/uniprot/G1S9Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:MPP3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GIR2 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/61853:LOC100581408 ^@ http://purl.uniprot.org/uniprot/G1S348 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/61853:CNOT10 ^@ http://purl.uniprot.org/uniprot/G1QWN2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT10 family.|||Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:RSPH3 ^@ http://purl.uniprot.org/uniprot/G1RJE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the flagellar radial spoke RSP3 family.|||flagellum axoneme http://togogenome.org/gene/61853:MRPS9 ^@ http://purl.uniprot.org/uniprot/A0A2I3FZS6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/61853:YIF1B ^@ http://purl.uniprot.org/uniprot/A0A2I3HXL8|||http://purl.uniprot.org/uniprot/G1S4V0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Membrane http://togogenome.org/gene/61853:AK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H2Q6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK1 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer. http://togogenome.org/gene/61853:NLN ^@ http://purl.uniprot.org/uniprot/A0A2I3HC35 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/61853:ALKAL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3FW02|||http://purl.uniprot.org/uniprot/G1QJ05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALKAL family.|||Secreted http://togogenome.org/gene/61853:IFNG ^@ http://purl.uniprot.org/uniprot/G1QTG5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II (or gamma) interferon family.|||Homodimer.|||Secreted|||Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation. http://togogenome.org/gene/61853:NDUFA11 ^@ http://purl.uniprot.org/uniprot/A0A2I3HHP2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA11 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:GSKIP ^@ http://purl.uniprot.org/uniprot/A0A2I3GZL3 ^@ Similarity ^@ Belongs to the GSKIP family. http://togogenome.org/gene/61853:PFKFB1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H9T5 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/61853:SOX14 ^@ http://purl.uniprot.org/uniprot/G1SBJ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:GNAL ^@ http://purl.uniprot.org/uniprot/A0A2I3HJU5 ^@ Similarity ^@ Belongs to the G-alpha family. G(s) subfamily. http://togogenome.org/gene/61853:SMPX ^@ http://purl.uniprot.org/uniprot/G1RFV4 ^@ Function|||Similarity ^@ Belongs to the SMPX family.|||Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. http://togogenome.org/gene/61853:SLC25A22 ^@ http://purl.uniprot.org/uniprot/G1RB98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/61853:PSMD8 ^@ http://purl.uniprot.org/uniprot/G1S4R1 ^@ Similarity ^@ Belongs to the proteasome subunit S14 family. http://togogenome.org/gene/61853:NQO2 ^@ http://purl.uniprot.org/uniprot/A0A2I3FRJ9|||http://purl.uniprot.org/uniprot/G1RJM5 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/61853:HSPA6 ^@ http://purl.uniprot.org/uniprot/G1SBW1 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/61853:GRPEL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GK17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/61853:CHRM5 ^@ http://purl.uniprot.org/uniprot/G1SBZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/61853:ASF1A ^@ http://purl.uniprot.org/uniprot/G1RT18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/61853:GDPGP1 ^@ http://purl.uniprot.org/uniprot/G1SB57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GDPGP1 family.|||Cytoplasm|||Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells. http://togogenome.org/gene/61853:RPL17 ^@ http://purl.uniprot.org/uniprot/A0A2I3GXY8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/61853:CANX ^@ http://purl.uniprot.org/uniprot/G1QM21 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/61853:JAGN1 ^@ http://purl.uniprot.org/uniprot/G1QVZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the jagunal family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:FUNDC1 ^@ http://purl.uniprot.org/uniprot/G1QQ35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/61853:NKX2-2 ^@ http://purl.uniprot.org/uniprot/G1RG95 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:WEE1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HLW5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.|||Binds 2 magnesium ions per subunit.|||Nucleus http://togogenome.org/gene/61853:TRPC4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GSH6|||http://purl.uniprot.org/uniprot/A0A2I3H8F3|||http://purl.uniprot.org/uniprot/A0A2I3HVM6|||http://purl.uniprot.org/uniprot/G1QQ58 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:NR1H2 ^@ http://purl.uniprot.org/uniprot/G1R0V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/61853:LOC100583662 ^@ http://purl.uniprot.org/uniprot/G1SC05 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:LOC100579320 ^@ http://purl.uniprot.org/uniprot/A0A2I3HUJ6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/61853:TPX2 ^@ http://purl.uniprot.org/uniprot/G1REX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TPX2 family.|||Nucleus|||spindle pole http://togogenome.org/gene/61853:ANAPC16 ^@ http://purl.uniprot.org/uniprot/A0A2I3FYA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC16 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||Cytoplasm|||Nucleus|||kinetochore http://togogenome.org/gene/61853:EIF2AK3 ^@ http://purl.uniprot.org/uniprot/G1QS89 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/61853:RPS27 ^@ http://purl.uniprot.org/uniprot/A0A2I3GMQ8 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/61853:ITPKA ^@ http://purl.uniprot.org/uniprot/G1QTX2 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/61853:SNRNP27 ^@ http://purl.uniprot.org/uniprot/G1RGK8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNUT3 family.|||May play a role in mRNA splicing.|||Nucleus|||Part of a tri-snRNP complex. http://togogenome.org/gene/61853:CYSTM1 ^@ http://purl.uniprot.org/uniprot/G1RDC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYSTM1 family.|||Membrane http://togogenome.org/gene/61853:PITX2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HKM7|||http://purl.uniprot.org/uniprot/G1S3A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/61853:ST7L ^@ http://purl.uniprot.org/uniprot/G1QVT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/61853:XKR5 ^@ http://purl.uniprot.org/uniprot/G1RY37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/61853:TGFBR2 ^@ http://purl.uniprot.org/uniprot/A0A2I3H3F9|||http://purl.uniprot.org/uniprot/G1QVR5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Cell membrane|||Membrane|||Membrane raft|||Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. http://togogenome.org/gene/61853:MRPL35 ^@ http://purl.uniprot.org/uniprot/A0A2I3GU82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bL35 family.|||Mitochondrion http://togogenome.org/gene/61853:MCL1 ^@ http://purl.uniprot.org/uniprot/G1RFT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Cytoplasm|||nucleoplasm http://togogenome.org/gene/61853:RPS12 ^@ http://purl.uniprot.org/uniprot/G1RWY9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family. http://togogenome.org/gene/61853:ABCG8 ^@ http://purl.uniprot.org/uniprot/G1S4D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/61853:SLC39A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HAJ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:HDAC1 ^@ http://purl.uniprot.org/uniprot/G1QQE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.|||Nucleus http://togogenome.org/gene/61853:TFEC ^@ http://purl.uniprot.org/uniprot/A0A2I3G980 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/61853:AQP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3I014 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/61853:CSNK1A1L ^@ http://purl.uniprot.org/uniprot/G1SAJ6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:PSMD2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HIP8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S2 family.|||Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/61853:LOC100581433 ^@ http://purl.uniprot.org/uniprot/G1SBV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:FREM3 ^@ http://purl.uniprot.org/uniprot/G1R043 ^@ Similarity ^@ Belongs to the FRAS1 family. http://togogenome.org/gene/61853:PYY ^@ http://purl.uniprot.org/uniprot/G1R0R6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/61853:PPP2R5C ^@ http://purl.uniprot.org/uniprot/A0A2I3G352|||http://purl.uniprot.org/uniprot/G1S0X1 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/61853:MANBAL ^@ http://purl.uniprot.org/uniprot/G1R344 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0239 family.|||Membrane http://togogenome.org/gene/61853:ZSCAN2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GXF6|||http://purl.uniprot.org/uniprot/A0A2I3GZV9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:DYNLT3 ^@ http://purl.uniprot.org/uniprot/G1QJS2 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/61853:GSK3B ^@ http://purl.uniprot.org/uniprot/A0A2I3GEZ5|||http://purl.uniprot.org/uniprot/G1QYY9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/61853:RNF31 ^@ http://purl.uniprot.org/uniprot/G1RZ82 ^@ Similarity ^@ Belongs to the RBR family. http://togogenome.org/gene/61853:LEP ^@ http://purl.uniprot.org/uniprot/G1RNX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the leptin family.|||Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells. Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38. In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses. Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation.|||Secreted http://togogenome.org/gene/61853:LOC100581228 ^@ http://purl.uniprot.org/uniprot/G1RGZ8 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/61853:FGF5 ^@ http://purl.uniprot.org/uniprot/G1RAW2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/61853:PRPF38B ^@ http://purl.uniprot.org/uniprot/G1QM59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||May be required for pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/61853:SEC61A1 ^@ http://purl.uniprot.org/uniprot/G1RVT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:RPA1 ^@ http://purl.uniprot.org/uniprot/G1S5P9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.|||Belongs to the replication factor A protein 1 family.|||Component of the heterotrimeric canonical replication protein A complex (RPA).|||PML body http://togogenome.org/gene/61853:NAT2 ^@ http://purl.uniprot.org/uniprot/G1QS63 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/61853:TRAF6 ^@ http://purl.uniprot.org/uniprot/G1S8G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family. A subfamily.|||Lipid droplet|||Nucleus|||cell cortex http://togogenome.org/gene/61853:RPS13 ^@ http://purl.uniprot.org/uniprot/A0A2I3FWD3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/61853:TBCA ^@ http://purl.uniprot.org/uniprot/A0A2I3GWX4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCA family.|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.|||Tubulin-folding protein; involved in the early step of the tubulin folding pathway.|||cytoskeleton http://togogenome.org/gene/61853:AKAP8 ^@ http://purl.uniprot.org/uniprot/G1QZJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AKAP95 family.|||Nucleus matrix http://togogenome.org/gene/61853:ELMO1 ^@ http://purl.uniprot.org/uniprot/G1QQ57 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/61853:LOC100605539 ^@ http://purl.uniprot.org/uniprot/G1QMK5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:HACL1 ^@ http://purl.uniprot.org/uniprot/G1QL60 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/61853:GRIA1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H9K1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/61853:LPAR6 ^@ http://purl.uniprot.org/uniprot/A0A2I3FQI3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:LOC100589494 ^@ http://purl.uniprot.org/uniprot/G1QRP6 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Theta family.|||Homodimer. http://togogenome.org/gene/61853:CASR ^@ http://purl.uniprot.org/uniprot/G1QHE9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:NAP1L1 ^@ http://purl.uniprot.org/uniprot/G1QXS6 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/61853:PRKCE ^@ http://purl.uniprot.org/uniprot/G1S4U2 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.|||Cell membrane|||Cytoplasm|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.|||Nucleus|||cytoskeleton|||perinuclear region http://togogenome.org/gene/61853:NFE2L2 ^@ http://purl.uniprot.org/uniprot/M3ZA41 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/61853:PTPN4 ^@ http://purl.uniprot.org/uniprot/G1QJB6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||May act at junctions between the membrane and the cytoskeleton.|||cytoskeleton http://togogenome.org/gene/61853:NIBAN1 ^@ http://purl.uniprot.org/uniprot/G1S8R2 ^@ Similarity ^@ Belongs to the Niban family. http://togogenome.org/gene/61853:MBOAT1 ^@ http://purl.uniprot.org/uniprot/G1QMB0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:LOC100582227 ^@ http://purl.uniprot.org/uniprot/A0A2I3GD22 ^@ Similarity ^@ Belongs to the cornifin (SPRR) family. http://togogenome.org/gene/61853:LOC100595735 ^@ http://purl.uniprot.org/uniprot/A0A2I3H3D5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/61853:TNFAIP6 ^@ http://purl.uniprot.org/uniprot/G1RJ80 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:MAPK7 ^@ http://purl.uniprot.org/uniprot/G1RBW1 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/61853:PROK2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HKU8|||http://purl.uniprot.org/uniprot/G1QQP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/61853:SPOUT1 ^@ http://purl.uniprot.org/uniprot/G1S7A0 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. http://togogenome.org/gene/61853:IL36G ^@ http://purl.uniprot.org/uniprot/A0A2I3GMW0|||http://purl.uniprot.org/uniprot/G1QN31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/61853:MBOAT4 ^@ http://purl.uniprot.org/uniprot/G1RMI9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:TTI2 ^@ http://purl.uniprot.org/uniprot/G1RN88 ^@ Similarity ^@ Belongs to the TTI2 family. http://togogenome.org/gene/61853:CNOT11 ^@ http://purl.uniprot.org/uniprot/G1RWI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT11 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:PON2 ^@ http://purl.uniprot.org/uniprot/G1S130 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated. http://togogenome.org/gene/61853:CD52 ^@ http://purl.uniprot.org/uniprot/G1RDK8 ^@ Function|||Subcellular Location Annotation ^@ May play a role in carrying and orienting carbohydrate, as well as having a more specific role.|||Membrane http://togogenome.org/gene/61853:MTIF2 ^@ http://purl.uniprot.org/uniprot/G1RDE2 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/61853:TAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GU35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.|||Membrane http://togogenome.org/gene/61853:HPRT1 ^@ http://purl.uniprot.org/uniprot/G1QNB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/61853:VPS11 ^@ http://purl.uniprot.org/uniprot/G1R733 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS11 family.|||Cytoplasmic vesicle|||Early endosome|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.|||autophagosome|||clathrin-coated vesicle http://togogenome.org/gene/61853:GPN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HNZ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.|||Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/61853:NDUFB3 ^@ http://purl.uniprot.org/uniprot/G1R5J2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB3 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:UNC5CL ^@ http://purl.uniprot.org/uniprot/G1QYX1 ^@ Similarity ^@ Belongs to the unc-5 family. http://togogenome.org/gene/61853:ASB10 ^@ http://purl.uniprot.org/uniprot/A0A2I3G2M1 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/61853:SLC25A32 ^@ http://purl.uniprot.org/uniprot/G1QUE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/61853:NAGK ^@ http://purl.uniprot.org/uniprot/A0A2I3HVP4 ^@ Similarity ^@ Belongs to the eukaryotic-type N-acetylglucosamine kinase family. http://togogenome.org/gene/61853:ALDH6A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HEX6 ^@ Function|||Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. http://togogenome.org/gene/61853:CLRN3 ^@ http://purl.uniprot.org/uniprot/G1QIC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/61853:LOC100593126 ^@ http://purl.uniprot.org/uniprot/G1S9J2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:KRT18 ^@ http://purl.uniprot.org/uniprot/G1S7N3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/61853:DENND10 ^@ http://purl.uniprot.org/uniprot/A0A2I3GS96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND10 family.|||Endosome|||Late endosome http://togogenome.org/gene/61853:GUCY2C ^@ http://purl.uniprot.org/uniprot/G1QUW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane http://togogenome.org/gene/61853:AMIGO1 ^@ http://purl.uniprot.org/uniprot/G1QRE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/61853:LOC100606185 ^@ http://purl.uniprot.org/uniprot/G1SBV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:NCOR1 ^@ http://purl.uniprot.org/uniprot/G1RXL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the N-CoR nuclear receptor corepressors family.|||Nucleus http://togogenome.org/gene/61853:CLCA4 ^@ http://purl.uniprot.org/uniprot/G1RGQ0 ^@ Similarity ^@ Belongs to the CLCR family. http://togogenome.org/gene/61853:GABRA2 ^@ http://purl.uniprot.org/uniprot/G1S691 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/61853:NPVF ^@ http://purl.uniprot.org/uniprot/G1RY10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FARP (FMRFamide related peptide) family.|||Secreted http://togogenome.org/gene/61853:EBF4 ^@ http://purl.uniprot.org/uniprot/G1RD02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/61853:PAF1 ^@ http://purl.uniprot.org/uniprot/G1RWE9 ^@ Similarity ^@ Belongs to the PAF1 family. http://togogenome.org/gene/61853:CPB2 ^@ http://purl.uniprot.org/uniprot/A0A2I3FWS6|||http://purl.uniprot.org/uniprot/G1QQD0 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/61853:LOC100580385 ^@ http://purl.uniprot.org/uniprot/H9H9Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine gamma family.|||Secreted http://togogenome.org/gene/61853:SAR1B ^@ http://purl.uniprot.org/uniprot/G1R9L5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/61853:GLIPR1L1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GBQ7|||http://purl.uniprot.org/uniprot/G1QXC1 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/61853:SEC22B ^@ http://purl.uniprot.org/uniprot/G1R0D5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Melanosome|||Membrane|||SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/61853:TCTEX1D1 ^@ http://purl.uniprot.org/uniprot/G1RZ44 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/61853:DUSP4 ^@ http://purl.uniprot.org/uniprot/G1S474 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/61853:SGPL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HQK0 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/61853:TMEM50A ^@ http://purl.uniprot.org/uniprot/G1RCU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/61853:MED8 ^@ http://purl.uniprot.org/uniprot/A0A2I3HT22 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 8 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/61853:STX17 ^@ http://purl.uniprot.org/uniprot/A0A2I3HYN6 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/61853:FAM167B ^@ http://purl.uniprot.org/uniprot/G1QPT1 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/61853:METTL26 ^@ http://purl.uniprot.org/uniprot/A0A2I3GJP8|||http://purl.uniprot.org/uniprot/A0A2I3H6D0|||http://purl.uniprot.org/uniprot/G1R9K0 ^@ Similarity ^@ Belongs to the UPF0585 family. http://togogenome.org/gene/61853:LOC100588845 ^@ http://purl.uniprot.org/uniprot/G1S9V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:TEKT5 ^@ http://purl.uniprot.org/uniprot/G1RGJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/61853:RIC8B ^@ http://purl.uniprot.org/uniprot/A0A2I3G2X8|||http://purl.uniprot.org/uniprot/A0A2I3HPI1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. http://togogenome.org/gene/61853:PRKG1 ^@ http://purl.uniprot.org/uniprot/G1RMZ0|||http://purl.uniprot.org/uniprot/G1RMZ8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. http://togogenome.org/gene/61853:LOC100588553 ^@ http://purl.uniprot.org/uniprot/G1RSS2 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/61853:SURF4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HCI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:LOC100601888 ^@ http://purl.uniprot.org/uniprot/G1S969 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:HAO2 ^@ http://purl.uniprot.org/uniprot/G1QZY8 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/61853:CENPO ^@ http://purl.uniprot.org/uniprot/A0A2I3G494 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-O/MCM21 family.|||Nucleus http://togogenome.org/gene/61853:ACKR3 ^@ http://purl.uniprot.org/uniprot/G1RIE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:ATP5MC3 ^@ http://purl.uniprot.org/uniprot/G1R202 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/61853:QTRT1 ^@ http://purl.uniprot.org/uniprot/G1RP20 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family.|||Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.|||Cytoplasm|||Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.|||Mitochondrion outer membrane http://togogenome.org/gene/61853:BTF3 ^@ http://purl.uniprot.org/uniprot/A0A2I3G128 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/61853:ARL6 ^@ http://purl.uniprot.org/uniprot/A0A2I3FYK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||cilium membrane http://togogenome.org/gene/61853:EDNRB ^@ http://purl.uniprot.org/uniprot/G1S310 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:ACADSB ^@ http://purl.uniprot.org/uniprot/A0A2I3GXB0 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/61853:PSMG2 ^@ http://purl.uniprot.org/uniprot/G1RCU5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PSMG2 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.|||Forms a heterodimer with PSMG1. http://togogenome.org/gene/61853:C23H8orf33 ^@ http://purl.uniprot.org/uniprot/G1RJN0 ^@ Similarity ^@ Belongs to the UPF0488 family. http://togogenome.org/gene/61853:SLC9A8 ^@ http://purl.uniprot.org/uniprot/G1R5N9 ^@ Similarity ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. http://togogenome.org/gene/61853:TSC22D3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HKB6|||http://purl.uniprot.org/uniprot/A0A2I3I045 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/61853:ATP2C2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GBS3|||http://purl.uniprot.org/uniprot/G1RK62 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:TUB ^@ http://purl.uniprot.org/uniprot/G1S6X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUB family.|||Secreted http://togogenome.org/gene/61853:IAH1 ^@ http://purl.uniprot.org/uniprot/G1RSQ7 ^@ Function|||Similarity ^@ Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.|||Probable lipase. http://togogenome.org/gene/61853:E2F2 ^@ http://purl.uniprot.org/uniprot/G1RB57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/61853:CDC45 ^@ http://purl.uniprot.org/uniprot/A0A2I3GXB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC45 family.|||Nucleus http://togogenome.org/gene/61853:DEF8 ^@ http://purl.uniprot.org/uniprot/A0A2I3G8E8 ^@ Similarity ^@ Belongs to the DEF8 family. http://togogenome.org/gene/61853:TFAP2D ^@ http://purl.uniprot.org/uniprot/G1QV54 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/61853:MET ^@ http://purl.uniprot.org/uniprot/G1RLI8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:AADACL2 ^@ http://purl.uniprot.org/uniprot/G1QTJ4 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/61853:LOC100597887 ^@ http://purl.uniprot.org/uniprot/A0A2I3HR35 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/61853:VSTM5 ^@ http://purl.uniprot.org/uniprot/G1R631 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:DPH6 ^@ http://purl.uniprot.org/uniprot/A0A2I3H740|||http://purl.uniprot.org/uniprot/A0A2I3HI86 ^@ Function|||Similarity ^@ Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.|||Belongs to the Diphthine--ammonia ligase family. http://togogenome.org/gene/61853:TENT5C ^@ http://purl.uniprot.org/uniprot/A0A2I3H148 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/61853:PYCR1 ^@ http://purl.uniprot.org/uniprot/G1RHA1 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/61853:ASPH ^@ http://purl.uniprot.org/uniprot/A0A2I3GZ41|||http://purl.uniprot.org/uniprot/A0A2I3HSK8 ^@ Subcellular Location Annotation ^@ Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/61853:UCHL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HF10 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/61853:ADAMTS9 ^@ http://purl.uniprot.org/uniprot/G1RMK1 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/61853:LXN ^@ http://purl.uniprot.org/uniprot/A0A2I3GPH9 ^@ Similarity ^@ Belongs to the protease inhibitor I47 (latexin) family. http://togogenome.org/gene/61853:FAM83D ^@ http://purl.uniprot.org/uniprot/A0A2I3H9G1 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/61853:RFTN2 ^@ http://purl.uniprot.org/uniprot/G1R5B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:ADGRF4 ^@ http://purl.uniprot.org/uniprot/G1QVZ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:ZKSCAN2 ^@ http://purl.uniprot.org/uniprot/G1RLZ9 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/61853:CCNYL1 ^@ http://purl.uniprot.org/uniprot/G1R667 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin Y subfamily. http://togogenome.org/gene/61853:FLT4 ^@ http://purl.uniprot.org/uniprot/G1QQ14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:AQP6 ^@ http://purl.uniprot.org/uniprot/A0A2I3HJD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/61853:TMEM242 ^@ http://purl.uniprot.org/uniprot/G1RIC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM242 family.|||Membrane http://togogenome.org/gene/61853:TEKT1 ^@ http://purl.uniprot.org/uniprot/G1RDP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/61853:CORO1A ^@ http://purl.uniprot.org/uniprot/A0A2I3GI37 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat coronin family.|||Binds actin.|||Membrane|||cell cortex|||cytoskeleton|||phagosome membrane http://togogenome.org/gene/61853:RDH10 ^@ http://purl.uniprot.org/uniprot/A0A2I3HQ71 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/61853:KCTD10 ^@ http://purl.uniprot.org/uniprot/G1QM64 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/61853:GRIA2 ^@ http://purl.uniprot.org/uniprot/G1R3B7|||http://purl.uniprot.org/uniprot/G1R3C2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/61853:LOC100582253 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBB2 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Theta family.|||Homodimer. http://togogenome.org/gene/61853:SV2A ^@ http://purl.uniprot.org/uniprot/G1REY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/61853:DCLK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3FX12 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:UBR1 ^@ http://purl.uniprot.org/uniprot/G1QXP3 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/61853:ASB3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HLT6 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/61853:ROMO1 ^@ http://purl.uniprot.org/uniprot/G1RHA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGR2 family.|||Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.|||Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:RAB5IF ^@ http://purl.uniprot.org/uniprot/A0A2I3HCU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:GJA5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GLU0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/61853:CUL5 ^@ http://purl.uniprot.org/uniprot/A0A2I3HAT7 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/61853:CRYGA ^@ http://purl.uniprot.org/uniprot/G1R676 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/61853:SPRR2B ^@ http://purl.uniprot.org/uniprot/A0A2I3GJR7 ^@ Similarity ^@ Belongs to the cornifin (SPRR) family. http://togogenome.org/gene/61853:DHODH ^@ http://purl.uniprot.org/uniprot/A0A2I3GMK8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:GTF2H3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HFK6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB4 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.|||Nucleus|||Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7. http://togogenome.org/gene/61853:MTCH1 ^@ http://purl.uniprot.org/uniprot/G1RJP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/61853:SLC66A3 ^@ http://purl.uniprot.org/uniprot/G1RUX0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:NME9 ^@ http://purl.uniprot.org/uniprot/A0A2I3FR14 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/61853:HBM ^@ http://purl.uniprot.org/uniprot/G1R944 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/61853:STAG1 ^@ http://purl.uniprot.org/uniprot/G1QVG1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/61853:DNAJC25 ^@ http://purl.uniprot.org/uniprot/A0A2I3H3B9 ^@ Similarity ^@ Belongs to the DNAJC25 family. http://togogenome.org/gene/61853:UTS2B ^@ http://purl.uniprot.org/uniprot/G1R4W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urotensin-2 family.|||Secreted http://togogenome.org/gene/61853:POLB ^@ http://purl.uniprot.org/uniprot/G1RQX7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Cytoplasm|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/61853:LIN9 ^@ http://purl.uniprot.org/uniprot/G1RUE6 ^@ Similarity ^@ Belongs to the lin-9 family. http://togogenome.org/gene/61853:HTRA2 ^@ http://purl.uniprot.org/uniprot/A0A2I3H871 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/61853:DIP2B ^@ http://purl.uniprot.org/uniprot/A0A2I3HLZ2 ^@ Similarity ^@ Belongs to the DIP2 family. http://togogenome.org/gene/61853:TDRD3 ^@ http://purl.uniprot.org/uniprot/G1S1E6 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1. http://togogenome.org/gene/61853:STN1 ^@ http://purl.uniprot.org/uniprot/G1RZ74 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the STN1 family.|||Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.|||Component of the CST complex.|||Nucleus|||telomere http://togogenome.org/gene/61853:TPI1 ^@ http://purl.uniprot.org/uniprot/G1QY88 ^@ Function|||Similarity|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Homodimer.|||It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.|||Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. http://togogenome.org/gene/61853:CLASP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3FU57|||http://purl.uniprot.org/uniprot/G1QKA9 ^@ Subcellular Location Annotation ^@ kinetochore http://togogenome.org/gene/61853:LOC100600217 ^@ http://purl.uniprot.org/uniprot/G1S1H8 ^@ Caution|||Similarity ^@ Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:B4GALNT1 ^@ http://purl.uniprot.org/uniprot/G1S612 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:ORM1 ^@ http://purl.uniprot.org/uniprot/G1S4I5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Functions as transport protein in the blood stream.|||Secreted http://togogenome.org/gene/61853:SCGB2A2 ^@ http://purl.uniprot.org/uniprot/A0A2I3H3X3|||http://purl.uniprot.org/uniprot/G1QTE4 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/61853:PDCD10 ^@ http://purl.uniprot.org/uniprot/G1QYB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDCD10 family.|||Cell membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:CLNS1A ^@ http://purl.uniprot.org/uniprot/G1S432 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pICln (TC 1.A.47) family.|||Nucleus http://togogenome.org/gene/61853:RNF13 ^@ http://purl.uniprot.org/uniprot/G1QSD2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:CNRIP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HH58 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CNRIP family.|||Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.|||Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. http://togogenome.org/gene/61853:PTH ^@ http://purl.uniprot.org/uniprot/G1S7I1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the parathyroid hormone family.|||Interacts with PTH1R (via N-terminal extracellular domain).|||PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.|||Secreted http://togogenome.org/gene/61853:MRPS16 ^@ http://purl.uniprot.org/uniprot/G1S3N8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/61853:VIP ^@ http://purl.uniprot.org/uniprot/G1RZQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/61853:GALT ^@ http://purl.uniprot.org/uniprot/A0A2I3GC08 ^@ Cofactor|||Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/61853:BPIFC ^@ http://purl.uniprot.org/uniprot/G1QYI0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Monomer. Homodimer; disulfide-linked.|||Secreted|||The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.|||The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.|||The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. http://togogenome.org/gene/61853:LOC100596593 ^@ http://purl.uniprot.org/uniprot/A0A2I3GCA4 ^@ Similarity ^@ Belongs to the SPAN-X family. http://togogenome.org/gene/61853:SLC30A2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HKW8|||http://purl.uniprot.org/uniprot/G1RD69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/61853:LOC100600805 ^@ http://purl.uniprot.org/uniprot/A0A2I3GYM7|||http://purl.uniprot.org/uniprot/A0A2I3HYC1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:DDIT3 ^@ http://purl.uniprot.org/uniprot/G1S665 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Cytoplasm|||Heterodimer.|||Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.|||Nucleus|||Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.|||Ubiquitinated, leading to its degradation by the proteasome. http://togogenome.org/gene/61853:TPD52L2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GFX9|||http://purl.uniprot.org/uniprot/A0A2I3GST0|||http://purl.uniprot.org/uniprot/A0A2I3GYA3|||http://purl.uniprot.org/uniprot/A0A2I3HBG5|||http://purl.uniprot.org/uniprot/G1RGR3 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/61853:KCNB2 ^@ http://purl.uniprot.org/uniprot/G1QKQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.|||Cell membrane|||Membrane|||Perikaryon|||dendrite http://togogenome.org/gene/61853:SIAH1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GIT7 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/61853:CD5L ^@ http://purl.uniprot.org/uniprot/G1RRC5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:ROPN1L ^@ http://purl.uniprot.org/uniprot/G1RLV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ropporin family.|||flagellum http://togogenome.org/gene/61853:NCBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GLG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NCBP1 family.|||Nucleus http://togogenome.org/gene/61853:POGLUT3 ^@ http://purl.uniprot.org/uniprot/G1R6K8 ^@ Similarity ^@ Belongs to the KDELC family. http://togogenome.org/gene/61853:LAMP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GS77|||http://purl.uniprot.org/uniprot/G1RY84 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/61853:VEGFB ^@ http://purl.uniprot.org/uniprot/G1QY84 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/61853:TMEFF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HZ07 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:RPL9 ^@ http://purl.uniprot.org/uniprot/G1S5I0 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/61853:OPA3 ^@ http://purl.uniprot.org/uniprot/G1QP14|||http://purl.uniprot.org/uniprot/M3ZBA5 ^@ Function|||Similarity ^@ Belongs to the OPA3 family.|||May play some role in mitochondrial processes. http://togogenome.org/gene/61853:LOC100592128 ^@ http://purl.uniprot.org/uniprot/A0A2I3HWC5 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/61853:APOC4 ^@ http://purl.uniprot.org/uniprot/G1QME5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C4 family.|||May participate in lipoprotein metabolism.|||Secreted http://togogenome.org/gene/61853:S100A4 ^@ http://purl.uniprot.org/uniprot/G1RHG0 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/61853:TP63 ^@ http://purl.uniprot.org/uniprot/A0A2I3GNV1|||http://purl.uniprot.org/uniprot/A0A2I3H7C7|||http://purl.uniprot.org/uniprot/A0A2I3HR34|||http://purl.uniprot.org/uniprot/G1R4S5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.|||Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer.|||Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:SERINC5 ^@ http://purl.uniprot.org/uniprot/A0A2I3HZ74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/61853:CA10 ^@ http://purl.uniprot.org/uniprot/G1R914 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Does not have a catalytic activity. http://togogenome.org/gene/61853:MOCS2 ^@ http://purl.uniprot.org/uniprot/G1RJJ3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MoaE family. MOCS2B subfamily.|||Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.|||Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.|||This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.|||cytosol http://togogenome.org/gene/61853:HSD17B13 ^@ http://purl.uniprot.org/uniprot/A0A2I3GHP1|||http://purl.uniprot.org/uniprot/G1REA2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/61853:AMIGO3 ^@ http://purl.uniprot.org/uniprot/G1SA89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/61853:DDRGK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HZR3 ^@ Similarity ^@ Belongs to the DDRGK1 family. http://togogenome.org/gene/61853:C3AR1 ^@ http://purl.uniprot.org/uniprot/G1QMA7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Interacts with VGF-derived peptide TLQP-21.|||Membrane|||Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. http://togogenome.org/gene/61853:AKIRIN2 ^@ http://purl.uniprot.org/uniprot/G1RRH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/61853:ANAPC11 ^@ http://purl.uniprot.org/uniprot/G1RH68 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/61853:HOXC5 ^@ http://purl.uniprot.org/uniprot/G1S7G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/61853:CDCA5 ^@ http://purl.uniprot.org/uniprot/G1R099 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/61853:LOC100598307 ^@ http://purl.uniprot.org/uniprot/A0A7R8GUS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/61853:TRIM54 ^@ http://purl.uniprot.org/uniprot/G1QSL2 ^@ Function|||Subcellular Location Annotation ^@ May bind and stabilize microtubules during myotubes formation.|||Z line http://togogenome.org/gene/61853:ANXA1 ^@ http://purl.uniprot.org/uniprot/G1QL21 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the annexin family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome membrane|||Lateral cell membrane|||Membrane|||Nucleus|||The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.|||cilium|||extracellular exosome|||extracellular space|||phagocytic cup|||secretory vesicle lumen http://togogenome.org/gene/61853:TRMT2B ^@ http://purl.uniprot.org/uniprot/G1R7H6 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:HMGCLL1 ^@ http://purl.uniprot.org/uniprot/G1QSR6 ^@ Similarity ^@ Belongs to the HMG-CoA lyase family. http://togogenome.org/gene/61853:HDAC3 ^@ http://purl.uniprot.org/uniprot/G1REQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/61853:FGF12 ^@ http://purl.uniprot.org/uniprot/A0A2I3GG73|||http://purl.uniprot.org/uniprot/G1R4X8 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/61853:SERPINA5 ^@ http://purl.uniprot.org/uniprot/G1S667 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/61853:BRPF1 ^@ http://purl.uniprot.org/uniprot/G1QVN6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:PPP2R2C ^@ http://purl.uniprot.org/uniprot/G1RM57 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/61853:TMEM54 ^@ http://purl.uniprot.org/uniprot/G1QS03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM54 family.|||Membrane http://togogenome.org/gene/61853:LOC100599925 ^@ http://purl.uniprot.org/uniprot/G1SB22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/61853:CACNG3 ^@ http://purl.uniprot.org/uniprot/G1RMK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane http://togogenome.org/gene/61853:GPC5 ^@ http://purl.uniprot.org/uniprot/G1S3B1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/61853:TMEM18 ^@ http://purl.uniprot.org/uniprot/G1RAG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM18 family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/61853:KCNJ11 ^@ http://purl.uniprot.org/uniprot/A0A2I3HLF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.|||Membrane http://togogenome.org/gene/61853:NKIRAS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H2V3 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/61853:SERF1A ^@ http://purl.uniprot.org/uniprot/A0A2I3G0K4|||http://purl.uniprot.org/uniprot/G1QWT3 ^@ Similarity ^@ Belongs to the SERF family. http://togogenome.org/gene/61853:LYVE1 ^@ http://purl.uniprot.org/uniprot/G1S773 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:CKS2 ^@ http://purl.uniprot.org/uniprot/A0A2I3H505 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/61853:BCL7C ^@ http://purl.uniprot.org/uniprot/A0A2I3HB39|||http://purl.uniprot.org/uniprot/G1S1S2 ^@ Similarity ^@ Belongs to the BCL7 family. http://togogenome.org/gene/61853:SLC11A2 ^@ http://purl.uniprot.org/uniprot/A0A2I3FTW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAMP family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/61853:ITGB3 ^@ http://purl.uniprot.org/uniprot/G1QXM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:LOC100605650 ^@ http://purl.uniprot.org/uniprot/G1QP67 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/61853:SUPV3L1 ^@ http://purl.uniprot.org/uniprot/G1RLC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family.|||mitochondrion nucleoid http://togogenome.org/gene/61853:MTTP ^@ http://purl.uniprot.org/uniprot/G1RU25 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:LOC100580069 ^@ http://purl.uniprot.org/uniprot/G1RY04 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/61853:ATP6V0A4 ^@ http://purl.uniprot.org/uniprot/G1RUK1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/61853:DMC1 ^@ http://purl.uniprot.org/uniprot/G1RYR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. DMC1 subfamily.|||May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.|||Nucleus http://togogenome.org/gene/61853:XRN1 ^@ http://purl.uniprot.org/uniprot/M3ZBU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-3' exonuclease family.|||Cytoplasm http://togogenome.org/gene/61853:THBS1 ^@ http://purl.uniprot.org/uniprot/G1QNM9 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:ENOPH1 ^@ http://purl.uniprot.org/uniprot/G1RBN0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.|||Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/61853:MDM4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HP90|||http://purl.uniprot.org/uniprot/M3ZAC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.|||Nucleus http://togogenome.org/gene/61853:PDCD5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GZM9 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/61853:BCAT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GPW5|||http://purl.uniprot.org/uniprot/G1QZ21 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/61853:TRAF5 ^@ http://purl.uniprot.org/uniprot/G1QQ79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/61853:CA2 ^@ http://purl.uniprot.org/uniprot/G1QRL6 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/61853:TLR3 ^@ http://purl.uniprot.org/uniprot/G1RKY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/61853:ACTBL2 ^@ http://purl.uniprot.org/uniprot/G1S9C9 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/61853:LOC100591198 ^@ http://purl.uniprot.org/uniprot/M3Z937 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG10 glucosyltransferase family.|||Membrane http://togogenome.org/gene/61853:PDCL ^@ http://purl.uniprot.org/uniprot/G1S5V1 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/61853:LIMD1 ^@ http://purl.uniprot.org/uniprot/G1R2B6 ^@ Similarity ^@ Belongs to the zyxin/ajuba family. http://togogenome.org/gene/61853:SF3B5 ^@ http://purl.uniprot.org/uniprot/G1SC94 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SF3B5 family.|||Component of the spliceosome B complex.|||Nucleus http://togogenome.org/gene/61853:AMPD1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GH93|||http://purl.uniprot.org/uniprot/G1QY15 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Homotetramer. http://togogenome.org/gene/61853:FOXI2 ^@ http://purl.uniprot.org/uniprot/G1QIC1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:PPIE ^@ http://purl.uniprot.org/uniprot/A0A2I3HCF9 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.|||Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. http://togogenome.org/gene/61853:PENK ^@ http://purl.uniprot.org/uniprot/G1QKU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Increases glutamate release in the striatum and decreases GABA concentration in the striatum.|||Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Secreted|||chromaffin granule lumen http://togogenome.org/gene/61853:APRT ^@ http://purl.uniprot.org/uniprot/G1S0B9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm http://togogenome.org/gene/61853:PRKAR2A ^@ http://purl.uniprot.org/uniprot/A0A2I3GJS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:MOB1A ^@ http://purl.uniprot.org/uniprot/G1QHK0 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/61853:ESCO2 ^@ http://purl.uniprot.org/uniprot/G1S3H2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:REXO4 ^@ http://purl.uniprot.org/uniprot/G1RRS7 ^@ Similarity ^@ Belongs to the REXO4 family. http://togogenome.org/gene/61853:DDX21 ^@ http://purl.uniprot.org/uniprot/G1RLM7 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily. http://togogenome.org/gene/61853:RASGRP3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GH82 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/61853:SPON1 ^@ http://purl.uniprot.org/uniprot/G1S7J0 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/61853:TDRD9 ^@ http://purl.uniprot.org/uniprot/G1S2J9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. http://togogenome.org/gene/61853:MTM1 ^@ http://purl.uniprot.org/uniprot/G1RT83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/61853:SAP30 ^@ http://purl.uniprot.org/uniprot/A0A2I3GSW2 ^@ Similarity ^@ Belongs to the SAP30 family. http://togogenome.org/gene/61853:MMAB ^@ http://purl.uniprot.org/uniprot/G1QNU1 ^@ Similarity ^@ Belongs to the Cob(I)alamin adenosyltransferase family. http://togogenome.org/gene/61853:CD3E ^@ http://purl.uniprot.org/uniprot/A0A2I3HEF8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:NAA40 ^@ http://purl.uniprot.org/uniprot/A0A2I3HB63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA40 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:RTCA ^@ http://purl.uniprot.org/uniprot/A0A2I3HIC5 ^@ Function|||Similarity ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. http://togogenome.org/gene/61853:MSRB2 ^@ http://purl.uniprot.org/uniprot/G1RQY7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit.|||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. http://togogenome.org/gene/61853:CA13 ^@ http://purl.uniprot.org/uniprot/A0A2I3GS17 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/61853:IGBP1 ^@ http://purl.uniprot.org/uniprot/G1QJ09 ^@ Similarity ^@ Belongs to the IGBP1/TAP42 family. http://togogenome.org/gene/61853:ALPG ^@ http://purl.uniprot.org/uniprot/G1RVL3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alkaline phosphatase family.|||Binds 1 Mg(2+) ion.|||Binds 2 Zn(2+) ions.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/61853:ND4 ^@ http://purl.uniprot.org/uniprot/E7EAD3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/61853:CHGB ^@ http://purl.uniprot.org/uniprot/G1RUK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/61853:SNX30 ^@ http://purl.uniprot.org/uniprot/A0A2I3GAI5 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/61853:MEX3A ^@ http://purl.uniprot.org/uniprot/G1RNZ7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/61853:FMO2 ^@ http://purl.uniprot.org/uniprot/G1RYT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/61853:LOC100600433 ^@ http://purl.uniprot.org/uniprot/G1SAF6 ^@ Similarity ^@ Belongs to the GroES chaperonin family. http://togogenome.org/gene/61853:EFS ^@ http://purl.uniprot.org/uniprot/G1RYE2 ^@ Similarity ^@ Belongs to the CAS family. http://togogenome.org/gene/61853:LEAP2 ^@ http://purl.uniprot.org/uniprot/G1RQW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LEAP2 family.|||Has an antimicrobial activity.|||Secreted http://togogenome.org/gene/61853:FGFR1OP ^@ http://purl.uniprot.org/uniprot/A0A2I3HST7|||http://purl.uniprot.org/uniprot/G1RLN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP43 family.|||centriole|||cilium basal body http://togogenome.org/gene/61853:NBN ^@ http://purl.uniprot.org/uniprot/A0A2I3GEG0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.|||Component of the MRN complex.|||Nucleus|||telomere http://togogenome.org/gene/61853:TSPAN6 ^@ http://purl.uniprot.org/uniprot/G1R7G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/61853:TUSC3 ^@ http://purl.uniprot.org/uniprot/G1QPB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:EIF4A3 ^@ http://purl.uniprot.org/uniprot/G1S090 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/61853:EIF5B ^@ http://purl.uniprot.org/uniprot/G1RVL0 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. http://togogenome.org/gene/61853:MRAP2 ^@ http://purl.uniprot.org/uniprot/G1RQH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:LOC100593825 ^@ http://purl.uniprot.org/uniprot/A0A2I3HWN6 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:SCRN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3FVY6|||http://purl.uniprot.org/uniprot/A0A2I3HPZ9 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/61853:IFNA8 ^@ http://purl.uniprot.org/uniprot/A0A2I3GCS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/61853:LOC100601477 ^@ http://purl.uniprot.org/uniprot/G1SAR0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:TMEM208 ^@ http://purl.uniprot.org/uniprot/A0A2I3GWJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM208 family.|||Endoplasmic reticulum membrane|||May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.|||Membrane http://togogenome.org/gene/61853:BMP5 ^@ http://purl.uniprot.org/uniprot/G1QSM4 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/61853:KRT5 ^@ http://purl.uniprot.org/uniprot/G1S7Q6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/61853:GAPDHS ^@ http://purl.uniprot.org/uniprot/G1RK80 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/61853:ASPHD1 ^@ http://purl.uniprot.org/uniprot/G1R7R7 ^@ Similarity ^@ Belongs to the aspartyl/asparaginyl beta-hydroxylase family. http://togogenome.org/gene/61853:SLC26A5 ^@ http://purl.uniprot.org/uniprot/A0A2I3H010|||http://purl.uniprot.org/uniprot/A0A2I3HUS7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:PTPRB ^@ http://purl.uniprot.org/uniprot/A0A2I3H359|||http://purl.uniprot.org/uniprot/A0A2I3H419 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. http://togogenome.org/gene/61853:PRDX1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HTB8 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/61853:ZNF280D ^@ http://purl.uniprot.org/uniprot/G1R4N7 ^@ Function|||Subcellular Location Annotation ^@ May function as a transcription factor.|||Nucleus http://togogenome.org/gene/61853:NLGN1 ^@ http://purl.uniprot.org/uniprot/G1R0S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:TGM5 ^@ http://purl.uniprot.org/uniprot/G1QYC6 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/61853:LOC100581313 ^@ http://purl.uniprot.org/uniprot/G1SCB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:TMSB4X ^@ http://purl.uniprot.org/uniprot/A0A2I3G9U4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/61853:PIGC ^@ http://purl.uniprot.org/uniprot/G1RZ26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGC family.|||Membrane http://togogenome.org/gene/61853:HNF4G ^@ http://purl.uniprot.org/uniprot/A0A2I3G374 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/61853:MYLK2 ^@ http://purl.uniprot.org/uniprot/G1REZ3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Cytoplasm|||May interact with centrin. http://togogenome.org/gene/61853:CLCN5 ^@ http://purl.uniprot.org/uniprot/A0A2I3HN01|||http://purl.uniprot.org/uniprot/G1R9L3 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.|||Cell membrane|||Endosome membrane|||Golgi apparatus membrane|||Interacts with NEDD4 and NEDD4L.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:INKA2 ^@ http://purl.uniprot.org/uniprot/M3Z931 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INKA family.|||Nucleus http://togogenome.org/gene/61853:LOC100579964 ^@ http://purl.uniprot.org/uniprot/G1QKD3 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/61853:TUBGCP5 ^@ http://purl.uniprot.org/uniprot/G1RJN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/61853:ETV1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GJA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/61853:TMEM176A ^@ http://purl.uniprot.org/uniprot/G1QUV7 ^@ Similarity ^@ Belongs to the TMEM176 family. http://togogenome.org/gene/61853:FAM199X ^@ http://purl.uniprot.org/uniprot/G1RTF1 ^@ Similarity ^@ Belongs to the FAM199 family. http://togogenome.org/gene/61853:METTL14 ^@ http://purl.uniprot.org/uniprot/G1RC99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MT-A70-like family.|||Heterodimer; heterodimerizes with METTL3 to form an antiparallel heterodimer that constitutes an active methyltransferase.|||Nucleus|||The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells. http://togogenome.org/gene/61853:BMP2 ^@ http://purl.uniprot.org/uniprot/G1RV31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/61853:PRMT3 ^@ http://purl.uniprot.org/uniprot/G1S807 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:SMG8 ^@ http://purl.uniprot.org/uniprot/G1RB31 ^@ Function|||Similarity ^@ Belongs to the SMG8 family.|||Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. http://togogenome.org/gene/61853:HEATR5A ^@ http://purl.uniprot.org/uniprot/G1S1P3 ^@ Similarity ^@ Belongs to the HEATR5 family. http://togogenome.org/gene/61853:NGLY1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GJU1|||http://purl.uniprot.org/uniprot/G1QUL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transglutaminase-like superfamily. PNGase family.|||Cytoplasm|||Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. http://togogenome.org/gene/61853:HMOX2 ^@ http://purl.uniprot.org/uniprot/G1RFL6 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/61853:REEP5 ^@ http://purl.uniprot.org/uniprot/G1RLI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/61853:PPFIA2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GE29|||http://purl.uniprot.org/uniprot/A0A2I3GM61|||http://purl.uniprot.org/uniprot/A0A2I3GU64|||http://purl.uniprot.org/uniprot/A0A2I3HS41|||http://purl.uniprot.org/uniprot/G1QZL7 ^@ Similarity ^@ Belongs to the liprin family. Liprin-alpha subfamily. http://togogenome.org/gene/61853:MRPL2 ^@ http://purl.uniprot.org/uniprot/G1QWI3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/61853:BFSP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GPY7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||cell cortex|||cytoskeleton http://togogenome.org/gene/61853:TRAPPC1 ^@ http://purl.uniprot.org/uniprot/G1RFD7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/61853:LIN28A ^@ http://purl.uniprot.org/uniprot/A0A2I3GBC7 ^@ Similarity ^@ Belongs to the lin-28 family. http://togogenome.org/gene/61853:LOC100601437 ^@ http://purl.uniprot.org/uniprot/G1RRD4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/61853:GLDN ^@ http://purl.uniprot.org/uniprot/G1R3I4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:PPP1CA ^@ http://purl.uniprot.org/uniprot/G1R3I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||nucleolus|||nucleoplasm http://togogenome.org/gene/61853:TCP11L2 ^@ http://purl.uniprot.org/uniprot/G1R4H6 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/61853:EIF3I ^@ http://purl.uniprot.org/uniprot/G1QPS5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit I family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Phosphorylated by TGF-beta type II receptor. http://togogenome.org/gene/61853:LY6D ^@ http://purl.uniprot.org/uniprot/G1QKY9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:RNGTT ^@ http://purl.uniprot.org/uniprot/A0A2I3FRX4|||http://purl.uniprot.org/uniprot/G1RRK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.|||In the C-terminal section; belongs to the eukaryotic GTase family.|||In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.|||Nucleus http://togogenome.org/gene/61853:SPARC ^@ http://purl.uniprot.org/uniprot/G1S383 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.|||Belongs to the SPARC family.|||Membrane|||basement membrane http://togogenome.org/gene/61853:PGGT1B ^@ http://purl.uniprot.org/uniprot/G1RM16 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit beta family. http://togogenome.org/gene/61853:LYPLAL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H8E3 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/61853:CASP4 ^@ http://purl.uniprot.org/uniprot/G1R6F5 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/61853:NUDC ^@ http://purl.uniprot.org/uniprot/G1RE19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudC family.|||Midbody|||spindle http://togogenome.org/gene/61853:SEMA6A ^@ http://purl.uniprot.org/uniprot/A0A2I3HCY1|||http://purl.uniprot.org/uniprot/A0A2I3HLT7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:LOC100604647 ^@ http://purl.uniprot.org/uniprot/G1QP52 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/61853:NDUFB4 ^@ http://purl.uniprot.org/uniprot/G1R832 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB4 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:BTBD10 ^@ http://purl.uniprot.org/uniprot/A0A2I3GJC2|||http://purl.uniprot.org/uniprot/G1S7H9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:ELAVL4 ^@ http://purl.uniprot.org/uniprot/A0A2I3FZL4|||http://purl.uniprot.org/uniprot/A0A2I3G9F8|||http://purl.uniprot.org/uniprot/A0A2I3GHA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm|||Perikaryon|||axon|||dendrite|||growth cone http://togogenome.org/gene/61853:HYAL2 ^@ http://purl.uniprot.org/uniprot/G1R5P7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/61853:NEDD8 ^@ http://purl.uniprot.org/uniprot/A0A2I3G605 ^@ Similarity ^@ Belongs to the ubiquitin family. http://togogenome.org/gene/61853:THRB ^@ http://purl.uniprot.org/uniprot/A0A2I3FV35|||http://purl.uniprot.org/uniprot/G1QTX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/61853:ND6 ^@ http://purl.uniprot.org/uniprot/D4QAU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 6 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/61853:BMPR1A ^@ http://purl.uniprot.org/uniprot/G1QPZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/61853:LOC100607862 ^@ http://purl.uniprot.org/uniprot/G1S975 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:TNP2 ^@ http://purl.uniprot.org/uniprot/G1SA05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear transition protein 2 family.|||Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.|||nucleolus http://togogenome.org/gene/61853:SSR1 ^@ http://purl.uniprot.org/uniprot/G1RLH8|||http://purl.uniprot.org/uniprot/M3ZAD8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-alpha family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.|||Membrane|||Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. http://togogenome.org/gene/61853:CHRND ^@ http://purl.uniprot.org/uniprot/G1RVV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/61853:GATAD2A ^@ http://purl.uniprot.org/uniprot/A0A2I3HAJ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:RETREG1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H7X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RETREG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:HBS1L ^@ http://purl.uniprot.org/uniprot/A0A2I3H7A2|||http://purl.uniprot.org/uniprot/A0A2I3HA64|||http://purl.uniprot.org/uniprot/G1RXF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm http://togogenome.org/gene/61853:PLOD2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HGQ8|||http://purl.uniprot.org/uniprot/G1QYT5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/61853:ZSCAN22 ^@ http://purl.uniprot.org/uniprot/A0A2I3GMM2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:NKX2-3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HMF5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:MCU ^@ http://purl.uniprot.org/uniprot/G1S385 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCU (TC 1.A.77) family.|||Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).|||Membrane|||Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:TMEM30B ^@ http://purl.uniprot.org/uniprot/A0A2I3HQV8 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/61853:GHR ^@ http://purl.uniprot.org/uniprot/A0A2I3G2M2|||http://purl.uniprot.org/uniprot/A0A2I3HTG2|||http://purl.uniprot.org/uniprot/G1S401 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Cell membrane|||The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. http://togogenome.org/gene/61853:LOC100598627 ^@ http://purl.uniprot.org/uniprot/G1S0N3 ^@ Similarity ^@ Belongs to the SGT1 family. http://togogenome.org/gene/61853:DOK6 ^@ http://purl.uniprot.org/uniprot/G1RCZ4 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/61853:HSF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HL42|||http://purl.uniprot.org/uniprot/G1RTZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/61853:STX19 ^@ http://purl.uniprot.org/uniprot/G1QMZ1 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/61853:CCNL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HHG4 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/61853:DTNB ^@ http://purl.uniprot.org/uniprot/G1QL27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dystrophin family. Dystrobrevin subfamily.|||Cytoplasm http://togogenome.org/gene/61853:CCL21 ^@ http://purl.uniprot.org/uniprot/G1QXX4 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/61853:FLI1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H1Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/61853:LOC100596515 ^@ http://purl.uniprot.org/uniprot/G1SBN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:RPL13 ^@ http://purl.uniprot.org/uniprot/A0A2I3GGJ1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/61853:LPAR4 ^@ http://purl.uniprot.org/uniprot/G1SBK7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:LOC100602226 ^@ http://purl.uniprot.org/uniprot/A0A2I3HMC1|||http://purl.uniprot.org/uniprot/G1RRG3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/61853:OAS2 ^@ http://purl.uniprot.org/uniprot/G1QGY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-5A synthase family.|||Cytoplasm http://togogenome.org/gene/61853:TBL1XR1 ^@ http://purl.uniprot.org/uniprot/G1R0W6 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/61853:LOC100606147 ^@ http://purl.uniprot.org/uniprot/G1RCE7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/61853:NUDT19 ^@ http://purl.uniprot.org/uniprot/G1R7V0 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/61853:S100A11 ^@ http://purl.uniprot.org/uniprot/G1RH69 ^@ Function|||Similarity|||Subunit ^@ Belongs to the S-100 family.|||Facilitates the differentiation and the cornification of keratinocytes.|||Homodimer; disulfide-linked. http://togogenome.org/gene/61853:SDR9C7 ^@ http://purl.uniprot.org/uniprot/G1S6M2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/61853:PARL ^@ http://purl.uniprot.org/uniprot/A0A2I3HNQ7|||http://purl.uniprot.org/uniprot/G1R2D6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:LOC100584083 ^@ http://purl.uniprot.org/uniprot/A0A2I3GMX3 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/61853:GLS2 ^@ http://purl.uniprot.org/uniprot/G1S6T0 ^@ Similarity ^@ Belongs to the glutaminase family. http://togogenome.org/gene/61853:SLC39A4 ^@ http://purl.uniprot.org/uniprot/G1RIF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Membrane http://togogenome.org/gene/61853:GK5 ^@ http://purl.uniprot.org/uniprot/G1QXP4 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/61853:SF3B6 ^@ http://purl.uniprot.org/uniprot/G1QJ63 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:EDN1 ^@ http://purl.uniprot.org/uniprot/G1QIY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/61853:PAGE2B ^@ http://purl.uniprot.org/uniprot/G1S2S0 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/61853:TPST1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H4C1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein sulfotransferase family.|||Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.|||Golgi apparatus membrane http://togogenome.org/gene/61853:GOSR1 ^@ http://purl.uniprot.org/uniprot/G1QU95 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GOSR1 family.|||Component of several multiprotein Golgi SNARE complexes.|||Golgi apparatus membrane|||Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.|||Membrane http://togogenome.org/gene/61853:ARL8B ^@ http://purl.uniprot.org/uniprot/A0A2I3H2M7 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||axon|||spindle http://togogenome.org/gene/61853:ACSS3 ^@ http://purl.uniprot.org/uniprot/G1QZG7 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/61853:CD46 ^@ http://purl.uniprot.org/uniprot/A0A2I3G5H4|||http://purl.uniprot.org/uniprot/A0A2I3H8B8|||http://purl.uniprot.org/uniprot/A0A2I3HJ87 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||acrosome inner membrane http://togogenome.org/gene/61853:GRIK2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GH36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/61853:GPR87 ^@ http://purl.uniprot.org/uniprot/G1QTF3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:ITPKB ^@ http://purl.uniprot.org/uniprot/G1RUG9 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/61853:KATNA1 ^@ http://purl.uniprot.org/uniprot/G1RZC6 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||Cytoplasm|||Midbody|||Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.|||The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.|||Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.|||centrosome|||spindle|||spindle pole http://togogenome.org/gene/61853:CAMK1G ^@ http://purl.uniprot.org/uniprot/G1QM17 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:TMEM144 ^@ http://purl.uniprot.org/uniprot/G1R3D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM144 family.|||Membrane http://togogenome.org/gene/61853:SMN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HCL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMN family.|||Cajal body|||Perikaryon|||Z line|||gem|||neuron projection http://togogenome.org/gene/61853:VKORC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G0U5|||http://purl.uniprot.org/uniprot/A0A2I3HF76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VKOR family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:PLA1A ^@ http://purl.uniprot.org/uniprot/A0A2I3HJ53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/61853:ZPBP ^@ http://purl.uniprot.org/uniprot/G1QXC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the zona pellucida-binding protein Sp38 family.|||Secreted|||acrosome http://togogenome.org/gene/61853:MRPL42 ^@ http://purl.uniprot.org/uniprot/A0A2I3GYF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL42 family.|||Mitochondrion http://togogenome.org/gene/61853:PROKR1 ^@ http://purl.uniprot.org/uniprot/G1RG68 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:TNFSF8 ^@ http://purl.uniprot.org/uniprot/A0A2I3HUZ1 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/61853:EIF2D ^@ http://purl.uniprot.org/uniprot/G1QIW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF2D family.|||Cytoplasm|||Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. http://togogenome.org/gene/61853:ARMCX1 ^@ http://purl.uniprot.org/uniprot/G1R7J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eutherian X-chromosome-specific Armcx family.|||Membrane http://togogenome.org/gene/61853:GSTA4 ^@ http://purl.uniprot.org/uniprot/G1QTY7 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/61853:EPHB1 ^@ http://purl.uniprot.org/uniprot/G1QUL1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||dendrite http://togogenome.org/gene/61853:CAVIN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HSB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/61853:PSMB1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GQJ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:SLC26A2 ^@ http://purl.uniprot.org/uniprot/G1RGU2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane|||Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion. http://togogenome.org/gene/61853:KIF5B ^@ http://purl.uniprot.org/uniprot/G1S940 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/61853:FAM151B ^@ http://purl.uniprot.org/uniprot/G1RR87 ^@ Similarity ^@ Belongs to the FAM151 family. http://togogenome.org/gene/61853:MEP1A ^@ http://purl.uniprot.org/uniprot/G1QWR5 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:GORASP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HNG8|||http://purl.uniprot.org/uniprot/G1R0J9 ^@ Similarity ^@ Belongs to the GORASP family. http://togogenome.org/gene/61853:SLC2A11 ^@ http://purl.uniprot.org/uniprot/A0A2I3GEW4|||http://purl.uniprot.org/uniprot/A0A2I3HVA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Cell membrane http://togogenome.org/gene/61853:LIN7C ^@ http://purl.uniprot.org/uniprot/A0A2I3GMY7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.|||Postsynaptic density membrane|||tight junction http://togogenome.org/gene/61853:CXCR3 ^@ http://purl.uniprot.org/uniprot/G1QK64 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Homomer. Forms heteromers with ACKR4.|||Membrane http://togogenome.org/gene/61853:CXCL13 ^@ http://purl.uniprot.org/uniprot/G1R9S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/61853:TMEM244 ^@ http://purl.uniprot.org/uniprot/G1RVS2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:LIPT2 ^@ http://purl.uniprot.org/uniprot/G1S568 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LipB family.|||Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.|||Mitochondrion http://togogenome.org/gene/61853:GPRIN3 ^@ http://purl.uniprot.org/uniprot/G1SAB7 ^@ Function ^@ May be involved in neurite outgrowth. http://togogenome.org/gene/61853:TGM4 ^@ http://purl.uniprot.org/uniprot/G1R263 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/61853:LOC100597841 ^@ http://purl.uniprot.org/uniprot/G1RNM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the misato family.|||Mitochondrion outer membrane http://togogenome.org/gene/61853:COLGALT2 ^@ http://purl.uniprot.org/uniprot/G1S8Q8 ^@ Similarity ^@ Belongs to the glycosyltransferase 25 family. http://togogenome.org/gene/61853:RBM47 ^@ http://purl.uniprot.org/uniprot/G1S5P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM RBM47 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:PRDM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GKR4|||http://purl.uniprot.org/uniprot/G1RS40 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.|||Nucleus|||Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. http://togogenome.org/gene/61853:SERPINB6 ^@ http://purl.uniprot.org/uniprot/A0A2I3HZC5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/61853:LOC100595867 ^@ http://purl.uniprot.org/uniprot/G1S9J2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:COX3 ^@ http://purl.uniprot.org/uniprot/E7EAE3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane http://togogenome.org/gene/61853:NTS ^@ http://purl.uniprot.org/uniprot/G1R004 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurotensin family.|||Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/61853:P2RX1 ^@ http://purl.uniprot.org/uniprot/G1S670 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/61853:SUSD6 ^@ http://purl.uniprot.org/uniprot/G1QLT4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:LMOD3 ^@ http://purl.uniprot.org/uniprot/G1QP22 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/61853:CKAP2L ^@ http://purl.uniprot.org/uniprot/G1QMS1 ^@ Similarity ^@ Belongs to the CKAP2 family. http://togogenome.org/gene/61853:RBM46 ^@ http://purl.uniprot.org/uniprot/A0A2I3GIV6|||http://purl.uniprot.org/uniprot/A0A2I3HHA4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:HSD17B10 ^@ http://purl.uniprot.org/uniprot/G1S1N0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/61853:PFKFB4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HHQ8 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/61853:PAX7 ^@ http://purl.uniprot.org/uniprot/G1R8G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/61853:DNAJC27 ^@ http://purl.uniprot.org/uniprot/G1QK63 ^@ Function|||Subunit ^@ GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.|||Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms). http://togogenome.org/gene/61853:SULT1C4 ^@ http://purl.uniprot.org/uniprot/G1RJ62 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/61853:NCOA2 ^@ http://purl.uniprot.org/uniprot/G1RKR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/61853:LOC100604305 ^@ http://purl.uniprot.org/uniprot/G1QYQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/61853:RIOK3 ^@ http://purl.uniprot.org/uniprot/G1R4W5 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.|||Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. http://togogenome.org/gene/61853:LOC100601784 ^@ http://purl.uniprot.org/uniprot/G1S990 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:NLRP14 ^@ http://purl.uniprot.org/uniprot/G1S6S9 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/61853:CRABP1 ^@ http://purl.uniprot.org/uniprot/G1RB18 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/61853:ANAPC13 ^@ http://purl.uniprot.org/uniprot/G1QUB7 ^@ Function|||Similarity ^@ Belongs to the APC13 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. http://togogenome.org/gene/61853:PON1 ^@ http://purl.uniprot.org/uniprot/G1S0R9 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated. http://togogenome.org/gene/61853:INA ^@ http://purl.uniprot.org/uniprot/G1RZ13 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/61853:PTAFR ^@ http://purl.uniprot.org/uniprot/G1RF84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ARRB1.|||Membrane|||Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/61853:PCSK5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GVQ1|||http://purl.uniprot.org/uniprot/G1QNB0 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/61853:AKR1B1 ^@ http://purl.uniprot.org/uniprot/G1RRK6 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/61853:THRSP ^@ http://purl.uniprot.org/uniprot/A0A2I3HQS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:LOC100601272 ^@ http://purl.uniprot.org/uniprot/A0A2I3GHZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histatin/statherin family.|||Secreted http://togogenome.org/gene/61853:RPL35A ^@ http://purl.uniprot.org/uniprot/A0A2I3H7B7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/61853:C4H18orf32 ^@ http://purl.uniprot.org/uniprot/G1RLD4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UPF0729 family.|||Interacts with DERL1 and AMFR.|||Lipid droplet|||May activate the NF-kappa-B signaling pathway. http://togogenome.org/gene/61853:CNEP1R1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H753|||http://purl.uniprot.org/uniprot/A0A2I3HQ29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNEP1R1 family.|||Cytoplasm|||Membrane|||Nucleus membrane http://togogenome.org/gene/61853:MYLK4 ^@ http://purl.uniprot.org/uniprot/G1RJ43 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:NGDN ^@ http://purl.uniprot.org/uniprot/A0A2I3GN57 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/61853:LOC100600134 ^@ http://purl.uniprot.org/uniprot/G1RK06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:CXCL9 ^@ http://purl.uniprot.org/uniprot/G1R9E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/61853:PSMC5 ^@ http://purl.uniprot.org/uniprot/G1QVT4 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/61853:CFLAR ^@ http://purl.uniprot.org/uniprot/G1R5J7 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/61853:BARHL2 ^@ http://purl.uniprot.org/uniprot/G1RH20 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:SLC45A3 ^@ http://purl.uniprot.org/uniprot/G1RWS9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:KRT71 ^@ http://purl.uniprot.org/uniprot/G1S7Q3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/61853:CTSD ^@ http://purl.uniprot.org/uniprot/G1RSC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Lysosome|||extracellular space http://togogenome.org/gene/61853:NR0B2 ^@ http://purl.uniprot.org/uniprot/G1RDZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:PPA1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GMS5 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/61853:GUCA2B ^@ http://purl.uniprot.org/uniprot/G1RNU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/61853:PIWIL3 ^@ http://purl.uniprot.org/uniprot/G1R819 ^@ Similarity ^@ Belongs to the argonaute family. http://togogenome.org/gene/61853:MCMBP ^@ http://purl.uniprot.org/uniprot/G1S4C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCMBP family.|||Nucleus http://togogenome.org/gene/61853:ARHGEF9 ^@ http://purl.uniprot.org/uniprot/A0A2I3HJH7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.|||Cytoplasm|||Interacts with GPHN.|||Postsynaptic density http://togogenome.org/gene/61853:PTGES2 ^@ http://purl.uniprot.org/uniprot/G1S6Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GST superfamily.|||Membrane http://togogenome.org/gene/61853:HS3ST4 ^@ http://purl.uniprot.org/uniprot/A0A2I3H788 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/61853:COQ7 ^@ http://purl.uniprot.org/uniprot/A0A2I3H0N0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ7 family.|||Binds 2 iron ions per subunit.|||Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:LOC100588416 ^@ http://purl.uniprot.org/uniprot/G1S9J2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:ERGIC1 ^@ http://purl.uniprot.org/uniprot/G1QHW3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/61853:CD6 ^@ http://purl.uniprot.org/uniprot/A0A2I3G8M9|||http://purl.uniprot.org/uniprot/A0A2I3GST4|||http://purl.uniprot.org/uniprot/A0A2I3H0Y2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:BTG4 ^@ http://purl.uniprot.org/uniprot/G1R6M7 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/61853:UPF3A ^@ http://purl.uniprot.org/uniprot/A0A2I3HVH8|||http://purl.uniprot.org/uniprot/G1R7L8 ^@ Similarity ^@ Belongs to the RENT3 family. http://togogenome.org/gene/61853:CMTM6 ^@ http://purl.uniprot.org/uniprot/G1QW74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:CEMIP2 ^@ http://purl.uniprot.org/uniprot/G1QJU1 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/61853:OAF ^@ http://purl.uniprot.org/uniprot/G1R753 ^@ Similarity ^@ Belongs to the OAF family. http://togogenome.org/gene/61853:SMPD2 ^@ http://purl.uniprot.org/uniprot/G1RPW2 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/61853:IL20 ^@ http://purl.uniprot.org/uniprot/A0A2I3GLA8|||http://purl.uniprot.org/uniprot/G1QJ75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/61853:PITHD1 ^@ http://purl.uniprot.org/uniprot/G1RBE3 ^@ Similarity ^@ Belongs to the PITHD1 family. http://togogenome.org/gene/61853:PRKACB ^@ http://purl.uniprot.org/uniprot/A0A2I3G8D7|||http://purl.uniprot.org/uniprot/A0A2I3GCI8|||http://purl.uniprot.org/uniprot/A0A2I3GYG9|||http://purl.uniprot.org/uniprot/A0A2I3H8D0|||http://purl.uniprot.org/uniprot/G1RFR2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/61853:HSCB ^@ http://purl.uniprot.org/uniprot/G1QPI3 ^@ Similarity ^@ Belongs to the HscB family. http://togogenome.org/gene/61853:ERO1A ^@ http://purl.uniprot.org/uniprot/G1RPM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EROs family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/61853:DUOXA2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HZI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DUOXA family.|||Membrane http://togogenome.org/gene/61853:UGP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GFJ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Homooctamer.|||UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. http://togogenome.org/gene/61853:MEF2C ^@ http://purl.uniprot.org/uniprot/A0A2I3HY69 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:NAP1L3 ^@ http://purl.uniprot.org/uniprot/G1QJC9 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/61853:PAPPA ^@ http://purl.uniprot.org/uniprot/G1S4T4 ^@ Caution|||Similarity ^@ Belongs to the peptidase M43B family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:GASK1B ^@ http://purl.uniprot.org/uniprot/A0A2I3G0W7 ^@ Similarity ^@ Belongs to the GASK family. http://togogenome.org/gene/61853:ATP8 ^@ http://purl.uniprot.org/uniprot/D4QAT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase protein 8 family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion membrane http://togogenome.org/gene/61853:PRKCQ ^@ http://purl.uniprot.org/uniprot/G1RM82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/61853:ADAM9 ^@ http://purl.uniprot.org/uniprot/A0A2I3GER4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:CBFB ^@ http://purl.uniprot.org/uniprot/G1QW78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF-beta family.|||Nucleus http://togogenome.org/gene/61853:LOC100605953 ^@ http://purl.uniprot.org/uniprot/A0A2I3H3Q3 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/61853:METTL4 ^@ http://purl.uniprot.org/uniprot/G1R593 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/61853:PCMTD1 ^@ http://purl.uniprot.org/uniprot/G1QIP4 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/61853:NOVA1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HMI5|||http://purl.uniprot.org/uniprot/A0A2I3HV42 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with PTBP2; the interaction is direct.|||Nucleus http://togogenome.org/gene/61853:TXNIP ^@ http://purl.uniprot.org/uniprot/G1R1H4 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/61853:TOMM7 ^@ http://purl.uniprot.org/uniprot/A0A2I3HZT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom7 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/61853:LOC100605653 ^@ http://purl.uniprot.org/uniprot/A0A2I3HS95 ^@ Similarity ^@ Belongs to the SPT20 family. http://togogenome.org/gene/61853:GALNTL5 ^@ http://purl.uniprot.org/uniprot/G1QXB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Membrane http://togogenome.org/gene/61853:KRT6A ^@ http://purl.uniprot.org/uniprot/A0A2I3GD99 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/61853:NDUFC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GLF8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFC1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:LTV1 ^@ http://purl.uniprot.org/uniprot/G1RYQ7 ^@ Similarity ^@ Belongs to the LTV1 family. http://togogenome.org/gene/61853:HTR2A ^@ http://purl.uniprot.org/uniprot/A0A2I3H7S9|||http://purl.uniprot.org/uniprot/G1QRK0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Presynapse|||Synapse|||Vesicle|||axon|||caveola|||dendrite http://togogenome.org/gene/61853:TRAPPC13 ^@ http://purl.uniprot.org/uniprot/G1QTS9|||http://purl.uniprot.org/uniprot/M3ZA02 ^@ Similarity|||Subunit ^@ Belongs to the TRAPPC13 family.|||Part of the multisubunit TRAPP (transport protein particle) complex. http://togogenome.org/gene/61853:SLC17A6 ^@ http://purl.uniprot.org/uniprot/G1S827 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:LHX8 ^@ http://purl.uniprot.org/uniprot/G1REJ8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:ASPN ^@ http://purl.uniprot.org/uniprot/G1S364 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||extracellular matrix http://togogenome.org/gene/61853:ISYNA1 ^@ http://purl.uniprot.org/uniprot/G1R290 ^@ Similarity ^@ Belongs to the myo-inositol 1-phosphate synthase family. http://togogenome.org/gene/61853:TXNL4A ^@ http://purl.uniprot.org/uniprot/A0A2I3GR22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/61853:TMOD1 ^@ http://purl.uniprot.org/uniprot/G1S4T8 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/61853:EIF2B5 ^@ http://purl.uniprot.org/uniprot/G1R2K0 ^@ Similarity ^@ Belongs to the eIF-2B gamma/epsilon subunits family. http://togogenome.org/gene/61853:LCA5 ^@ http://purl.uniprot.org/uniprot/G1RP79 ^@ Similarity ^@ Belongs to the LCA5 family. http://togogenome.org/gene/61853:INSL5 ^@ http://purl.uniprot.org/uniprot/G1RZ47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/61853:EIF1B ^@ http://purl.uniprot.org/uniprot/G1R0Y9 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/61853:SLC5A2 ^@ http://purl.uniprot.org/uniprot/G1S306 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:IL1RAPL1 ^@ http://purl.uniprot.org/uniprot/G1RGF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the interleukin-1 receptor family.|||axon|||dendrite http://togogenome.org/gene/61853:DNAAF4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GAS4|||http://purl.uniprot.org/uniprot/A0A2I3GXT7|||http://purl.uniprot.org/uniprot/G1R4D0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Dynein axonemal particle|||neuron projection http://togogenome.org/gene/61853:USP15 ^@ http://purl.uniprot.org/uniprot/A0A2I3FZN8|||http://purl.uniprot.org/uniprot/A0A2I3HDQ0|||http://purl.uniprot.org/uniprot/G1S5L1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Nucleus http://togogenome.org/gene/61853:ACAT1 ^@ http://purl.uniprot.org/uniprot/G1R6J0 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/61853:CDK2AP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G1N6|||http://purl.uniprot.org/uniprot/G1QLD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDK2AP family.|||Nucleus http://togogenome.org/gene/61853:FAP ^@ http://purl.uniprot.org/uniprot/A0A2I3GN71|||http://purl.uniprot.org/uniprot/G1QQS9 ^@ Subcellular Location Annotation ^@ Cell membrane|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/61853:SMIM8 ^@ http://purl.uniprot.org/uniprot/A0A2I3GW00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM8 family.|||Membrane http://togogenome.org/gene/61853:MAL ^@ http://purl.uniprot.org/uniprot/A0A2I3HEI9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:GPR37L1 ^@ http://purl.uniprot.org/uniprot/G1S8Y8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:CCNF ^@ http://purl.uniprot.org/uniprot/G1RDX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family.|||Nucleus|||centriole|||perinuclear region http://togogenome.org/gene/61853:IRF4 ^@ http://purl.uniprot.org/uniprot/G1RI69 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:CD68 ^@ http://purl.uniprot.org/uniprot/G1RES7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/61853:SLC46A2 ^@ http://purl.uniprot.org/uniprot/G1S3L5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:ATIC ^@ http://purl.uniprot.org/uniprot/G1R6I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PurH family.|||cytosol http://togogenome.org/gene/61853:GTF2H1 ^@ http://purl.uniprot.org/uniprot/G1S7T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB1 family.|||Nucleus http://togogenome.org/gene/61853:ZNF197 ^@ http://purl.uniprot.org/uniprot/A0A2I3GTQ2|||http://purl.uniprot.org/uniprot/G1R201 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:C2H16orf58 ^@ http://purl.uniprot.org/uniprot/G1S338 ^@ Similarity ^@ Belongs to the RUS1 family. http://togogenome.org/gene/61853:MRPL17 ^@ http://purl.uniprot.org/uniprot/A0A2I3HYX7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL17 family. http://togogenome.org/gene/61853:ATP8A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3I0G8|||http://purl.uniprot.org/uniprot/G1S657 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/61853:ISCU ^@ http://purl.uniprot.org/uniprot/A0A2I3H0V0|||http://purl.uniprot.org/uniprot/G1R501 ^@ Function|||Similarity ^@ Belongs to the NifU family.|||Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex. http://togogenome.org/gene/61853:BTC ^@ http://purl.uniprot.org/uniprot/G1R905 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:MAP2K4 ^@ http://purl.uniprot.org/uniprot/A0A2I3G2G1|||http://purl.uniprot.org/uniprot/G1RWT9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:FAM219B ^@ http://purl.uniprot.org/uniprot/G1RXA4 ^@ Similarity ^@ Belongs to the FAM219 family. http://togogenome.org/gene/61853:WT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HTM5|||http://purl.uniprot.org/uniprot/G1S896 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Cytoplasm|||Nucleus speckle http://togogenome.org/gene/61853:PRR5L ^@ http://purl.uniprot.org/uniprot/G1S8G4 ^@ Similarity ^@ Belongs to the PROTOR family. http://togogenome.org/gene/61853:PSMB8 ^@ http://purl.uniprot.org/uniprot/G1R4S9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:DEFB135 ^@ http://purl.uniprot.org/uniprot/G1RYL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/61853:CNKSR3 ^@ http://purl.uniprot.org/uniprot/A0A2I3FZ66 ^@ Similarity ^@ Belongs to the CNKSR family. http://togogenome.org/gene/61853:MS4A10 ^@ http://purl.uniprot.org/uniprot/G1RT59 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/61853:MOXD1 ^@ http://purl.uniprot.org/uniprot/G1RWT1 ^@ Similarity ^@ Belongs to the copper type II ascorbate-dependent monooxygenase family. http://togogenome.org/gene/61853:MAGOH ^@ http://purl.uniprot.org/uniprot/A0A2I3G4C3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/61853:GIMAP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H0S2 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/61853:RPL5 ^@ http://purl.uniprot.org/uniprot/G1RHR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/61853:STARD5 ^@ http://purl.uniprot.org/uniprot/G1QL54 ^@ Function ^@ May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols. http://togogenome.org/gene/61853:LOC100586323 ^@ http://purl.uniprot.org/uniprot/A0A2I3GDE3 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:PTTG1 ^@ http://purl.uniprot.org/uniprot/G1QWP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the securin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:TRPC5 ^@ http://purl.uniprot.org/uniprot/G1RWZ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:OXR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GYC8|||http://purl.uniprot.org/uniprot/A0A2I3H5H2|||http://purl.uniprot.org/uniprot/G1QVC1 ^@ Similarity ^@ Belongs to the OXR1 family. http://togogenome.org/gene/61853:F3 ^@ http://purl.uniprot.org/uniprot/G1RJV1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tissue factor family.|||Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.|||Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.|||Membrane http://togogenome.org/gene/61853:PHC3 ^@ http://purl.uniprot.org/uniprot/A0A2I3H7E8|||http://purl.uniprot.org/uniprot/G1QZD8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:CBFA2T2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GH88|||http://purl.uniprot.org/uniprot/A0A2I3HX66 ^@ Similarity ^@ Belongs to the CBFA2T family. http://togogenome.org/gene/61853:PSEN1 ^@ http://purl.uniprot.org/uniprot/G1QRH5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Cytoplasmic granule|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||Synapse|||The PAL motif is required for normal active site conformation.|||axon|||neuron projection http://togogenome.org/gene/61853:BET1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HWQ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:CNFN ^@ http://purl.uniprot.org/uniprot/G1RIE1 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/61853:ZBED1 ^@ http://purl.uniprot.org/uniprot/G1SAQ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:ARHGEF3 ^@ http://purl.uniprot.org/uniprot/A0A2I3H776|||http://purl.uniprot.org/uniprot/A0A2I3HMM0 ^@ Function|||Subcellular Location Annotation ^@ Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.|||Cytoplasm http://togogenome.org/gene/61853:ESRRA ^@ http://purl.uniprot.org/uniprot/G1QYL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/61853:SERPINB12 ^@ http://purl.uniprot.org/uniprot/G1RBV1 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/61853:LOC100588890 ^@ http://purl.uniprot.org/uniprot/G1QRB4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 6c family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:DCLRE1B ^@ http://purl.uniprot.org/uniprot/A0A2I3HII2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/61853:PSME2 ^@ http://purl.uniprot.org/uniprot/G1RZ59 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/61853:CALHM2 ^@ http://purl.uniprot.org/uniprot/G1RZ43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/61853:KIF20B ^@ http://purl.uniprot.org/uniprot/G1RP63 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/61853:ACO2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GCH6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.|||Mitochondrion http://togogenome.org/gene/61853:FOXO4 ^@ http://purl.uniprot.org/uniprot/A0A2I3H4R2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:LOC100580921 ^@ http://purl.uniprot.org/uniprot/G1RZ57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/61853:PPM1L ^@ http://purl.uniprot.org/uniprot/A0A2I3G3V5 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/61853:CRISP2 ^@ http://purl.uniprot.org/uniprot/G1QVL3 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:LYZL4 ^@ http://purl.uniprot.org/uniprot/G1R1F8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/61853:LOC100579700 ^@ http://purl.uniprot.org/uniprot/A0A0M6L0J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/61853:TIMM10 ^@ http://purl.uniprot.org/uniprot/G1RQK8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/61853:HACD1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HH69 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:LOC100584900 ^@ http://purl.uniprot.org/uniprot/G1SBS1 ^@ Similarity ^@ Belongs to the MORF4 family-associated protein family. http://togogenome.org/gene/61853:LOC100583707 ^@ http://purl.uniprot.org/uniprot/G1QJJ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCO1/2 family.|||Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2.|||Homodimer.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:PLIN5 ^@ http://purl.uniprot.org/uniprot/G1RSA4 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/61853:METTL6 ^@ http://purl.uniprot.org/uniprot/A0A2I3G9M1 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. METL family. http://togogenome.org/gene/61853:NPBWR1 ^@ http://purl.uniprot.org/uniprot/G1S9U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:CPSF4 ^@ http://purl.uniprot.org/uniprot/G1RJR0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CPSF4/YTH1 family.|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex.|||Nucleus http://togogenome.org/gene/61853:HTR2C ^@ http://purl.uniprot.org/uniprot/A0A2I3GU28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:IRF2BP1 ^@ http://purl.uniprot.org/uniprot/G1S9W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF2BP family.|||Nucleus http://togogenome.org/gene/61853:STATH ^@ http://purl.uniprot.org/uniprot/A0A2I3GGL2|||http://purl.uniprot.org/uniprot/G1R7Y6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histatin/statherin family.|||Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.|||Secreted http://togogenome.org/gene/61853:WNT10A ^@ http://purl.uniprot.org/uniprot/G1RCL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/61853:URM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G169|||http://purl.uniprot.org/uniprot/A0A2I3GQ10 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.|||Belongs to the URM1 family.|||C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.|||Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.|||Cytoplasm http://togogenome.org/gene/61853:GPR146 ^@ http://purl.uniprot.org/uniprot/G1SAP4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:CYGB ^@ http://purl.uniprot.org/uniprot/A0A2I3GBD3 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/61853:CLASP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HT73 ^@ Subcellular Location Annotation ^@ kinetochore http://togogenome.org/gene/61853:S100A5 ^@ http://purl.uniprot.org/uniprot/G1RHF8 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/61853:INS ^@ http://purl.uniprot.org/uniprot/A0A2I3HNQ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Heterodimer of a B chain and an A chain linked by two disulfide bonds.|||Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.|||Secreted http://togogenome.org/gene/61853:OSBPL11 ^@ http://purl.uniprot.org/uniprot/G1QJD0 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/61853:CFH ^@ http://purl.uniprot.org/uniprot/A0A2I3H3C6|||http://purl.uniprot.org/uniprot/G1S8U4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:HOXA11 ^@ http://purl.uniprot.org/uniprot/G1RYA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/61853:KCNK2 ^@ http://purl.uniprot.org/uniprot/G1RW39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/61853:AK5 ^@ http://purl.uniprot.org/uniprot/A0A2I3HD70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylate kinase family.|||Cytoplasm http://togogenome.org/gene/61853:ARR3 ^@ http://purl.uniprot.org/uniprot/G1QJ87 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/61853:HOXC9 ^@ http://purl.uniprot.org/uniprot/G1S7G4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/61853:NT5C2 ^@ http://purl.uniprot.org/uniprot/G1RZ09 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/61853:LAPTM5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GH06 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/61853:CLIC5 ^@ http://purl.uniprot.org/uniprot/A0A2I3G7Q1|||http://purl.uniprot.org/uniprot/G1QTT1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/61853:ACYP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HT97 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/61853:PSENEN ^@ http://purl.uniprot.org/uniprot/A0A2I3H000 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PEN-2 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/61853:DMRT2 ^@ http://purl.uniprot.org/uniprot/G1RB53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/61853:MRPL13 ^@ http://purl.uniprot.org/uniprot/A0A2I3GDU0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/61853:LOC100596162 ^@ http://purl.uniprot.org/uniprot/G1S3Y7 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/61853:LOC100580823 ^@ http://purl.uniprot.org/uniprot/G1QJ66 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Vesicle http://togogenome.org/gene/61853:BICC1 ^@ http://purl.uniprot.org/uniprot/G1RNV6 ^@ Similarity ^@ Belongs to the BicC family. http://togogenome.org/gene/61853:TRMT1L ^@ http://purl.uniprot.org/uniprot/G1S8R4 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||May play a role in motor coordination and exploratory behavior. http://togogenome.org/gene/61853:RPS6KB1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HB45 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/61853:ACOT8 ^@ http://purl.uniprot.org/uniprot/A0A2I3GHU4 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/61853:MPP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GYK9|||http://purl.uniprot.org/uniprot/A0A2I3HUA0 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/61853:MAP2K6 ^@ http://purl.uniprot.org/uniprot/G1QQD5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:SEMA7A ^@ http://purl.uniprot.org/uniprot/G1RWI4 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:LOC100599929 ^@ http://purl.uniprot.org/uniprot/A0A2I3GU47|||http://purl.uniprot.org/uniprot/G1R7W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/61853:MED18 ^@ http://purl.uniprot.org/uniprot/G1RFC3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 18 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/61853:BHMT ^@ http://purl.uniprot.org/uniprot/G1RQT1 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 zinc ion per subunit.|||Homotetramer.|||Involved in the regulation of homocysteine metabolism. http://togogenome.org/gene/61853:DOK5 ^@ http://purl.uniprot.org/uniprot/G1R5U3 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/61853:ATP6V1C1 ^@ http://purl.uniprot.org/uniprot/G1QU60 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/61853:GADD45A ^@ http://purl.uniprot.org/uniprot/G1RDG6 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/61853:GSDME ^@ http://purl.uniprot.org/uniprot/G1RXU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:BLOC1S1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GUI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BLOC1S1 family.|||Lysosome membrane|||May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.|||Mitochondrion intermembrane space http://togogenome.org/gene/61853:LOC100587351 ^@ http://purl.uniprot.org/uniprot/G1QTT2 ^@ Similarity ^@ Belongs to the SSX family. http://togogenome.org/gene/61853:MIF ^@ http://purl.uniprot.org/uniprot/G1QIN3 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/61853:URGCP ^@ http://purl.uniprot.org/uniprot/A0A2I3H1N0|||http://purl.uniprot.org/uniprot/A0A2I3HGF7|||http://purl.uniprot.org/uniprot/G1QT01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.|||Nucleus http://togogenome.org/gene/61853:STMN1 ^@ http://purl.uniprot.org/uniprot/G1RD61 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/61853:SNX8 ^@ http://purl.uniprot.org/uniprot/G1RBE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/61853:SEC62 ^@ http://purl.uniprot.org/uniprot/G1QZ87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC62 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:ZSCAN12 ^@ http://purl.uniprot.org/uniprot/A0A2I3HKR0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:RPL7A ^@ http://purl.uniprot.org/uniprot/G1RRJ8 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Component of the ribosome. http://togogenome.org/gene/61853:PRICKLE2 ^@ http://purl.uniprot.org/uniprot/G1RMD6 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/61853:MGAT1 ^@ http://purl.uniprot.org/uniprot/G1QQ23 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.|||Membrane|||The cofactor is mostly bound to the substrate. http://togogenome.org/gene/61853:TRAPPC4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GLC7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/61853:PCOLCE2 ^@ http://purl.uniprot.org/uniprot/G1QYC7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:SPA17 ^@ http://purl.uniprot.org/uniprot/G1R780 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates. http://togogenome.org/gene/61853:ARHGDIA ^@ http://purl.uniprot.org/uniprot/G1RH56 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/61853:LOC100582853 ^@ http://purl.uniprot.org/uniprot/A0A2I3GUA9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/61853:NOG ^@ http://purl.uniprot.org/uniprot/A0A2I3HGL4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the noggin family.|||Homodimer.|||Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.|||Secreted http://togogenome.org/gene/61853:SMAD9 ^@ http://purl.uniprot.org/uniprot/A0A2I3G2P5|||http://purl.uniprot.org/uniprot/G1QM38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:NEIL3 ^@ http://purl.uniprot.org/uniprot/G1S4I9 ^@ Similarity ^@ Belongs to the FPG family. http://togogenome.org/gene/61853:PGLYRP4 ^@ http://purl.uniprot.org/uniprot/G1RHE1 ^@ Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. http://togogenome.org/gene/61853:ILK ^@ http://purl.uniprot.org/uniprot/G1S6P2 ^@ Subcellular Location Annotation ^@ focal adhesion|||lamellipodium|||sarcomere http://togogenome.org/gene/61853:TMEM14B ^@ http://purl.uniprot.org/uniprot/G1QIG2 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/61853:DHH ^@ http://purl.uniprot.org/uniprot/G1S840 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hedgehog family.|||Cell membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Multimer.|||The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.|||The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. http://togogenome.org/gene/61853:MPEG1 ^@ http://purl.uniprot.org/uniprot/G1SCC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MPEG1 family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/61853:HOMER1 ^@ http://purl.uniprot.org/uniprot/G1RQW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/61853:CPEB3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HEM5|||http://purl.uniprot.org/uniprot/G1RPZ7 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/61853:ACER3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HV55 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:RXRB ^@ http://purl.uniprot.org/uniprot/G1R516 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Nucleus http://togogenome.org/gene/61853:PTCD2 ^@ http://purl.uniprot.org/uniprot/G1QX45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTCD2 family.|||Mitochondrion http://togogenome.org/gene/61853:MMUT ^@ http://purl.uniprot.org/uniprot/G1QVV1 ^@ Function|||Similarity ^@ Belongs to the methylmalonyl-CoA mutase family.|||Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. http://togogenome.org/gene/61853:SERPINB13 ^@ http://purl.uniprot.org/uniprot/A0A2I3HHW0 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/61853:AQP7 ^@ http://purl.uniprot.org/uniprot/G1QYZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/61853:DDI1 ^@ http://purl.uniprot.org/uniprot/G1SC27 ^@ Similarity ^@ Belongs to the DDI1 family. http://togogenome.org/gene/61853:CHRM2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GG77 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. http://togogenome.org/gene/61853:IWS1 ^@ http://purl.uniprot.org/uniprot/G1S0X5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:ENO4 ^@ http://purl.uniprot.org/uniprot/G1S3E2 ^@ Similarity ^@ Belongs to the enolase family. http://togogenome.org/gene/61853:CCT2 ^@ http://purl.uniprot.org/uniprot/G1QV23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/61853:GBX1 ^@ http://purl.uniprot.org/uniprot/G1QW66 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:DUSP10 ^@ http://purl.uniprot.org/uniprot/A0A2I3HVQ2 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/61853:SGO1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GJH9|||http://purl.uniprot.org/uniprot/A0A2I3HL99|||http://purl.uniprot.org/uniprot/G1QTK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shugoshin family.|||centromere http://togogenome.org/gene/61853:FGF20 ^@ http://purl.uniprot.org/uniprot/A0A2I3FZ33 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/61853:BMP3 ^@ http://purl.uniprot.org/uniprot/G1RAW8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer.|||Secreted http://togogenome.org/gene/61853:SLC16A13 ^@ http://purl.uniprot.org/uniprot/G1RDS4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:GMPR ^@ http://purl.uniprot.org/uniprot/G1QJZ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer. http://togogenome.org/gene/61853:SYT17 ^@ http://purl.uniprot.org/uniprot/A0A2I3H1N6|||http://purl.uniprot.org/uniprot/A0A2I3HPE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Membrane http://togogenome.org/gene/61853:CTLA4 ^@ http://purl.uniprot.org/uniprot/A0A2I3FRI8|||http://purl.uniprot.org/uniprot/G1R5Y1 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.|||Membrane http://togogenome.org/gene/61853:TM9SF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GNW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/61853:GMFB ^@ http://purl.uniprot.org/uniprot/G1RQB8 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily. http://togogenome.org/gene/61853:NME7 ^@ http://purl.uniprot.org/uniprot/G1RY63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||cilium axoneme http://togogenome.org/gene/61853:P4HA3 ^@ http://purl.uniprot.org/uniprot/G1S595 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/61853:AQR ^@ http://purl.uniprot.org/uniprot/G1RK35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CWF11 family.|||Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE.|||Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.|||Nucleus http://togogenome.org/gene/61853:RBBP7 ^@ http://purl.uniprot.org/uniprot/G1REL4|||http://purl.uniprot.org/uniprot/M3ZB33 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:FGF17 ^@ http://purl.uniprot.org/uniprot/A0A2I3H953 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/61853:EXOSC9 ^@ http://purl.uniprot.org/uniprot/A0A2I3GCY8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:PLAC8 ^@ http://purl.uniprot.org/uniprot/G1RCN7 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/61853:TEK ^@ http://purl.uniprot.org/uniprot/A0A2I3GP71|||http://purl.uniprot.org/uniprot/G1S2P7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:BLMH ^@ http://purl.uniprot.org/uniprot/A0A2I3H9L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Cytoplasm http://togogenome.org/gene/61853:TBC1D31 ^@ http://purl.uniprot.org/uniprot/A0A2I3GGL5|||http://purl.uniprot.org/uniprot/A0A2I3HVN0|||http://purl.uniprot.org/uniprot/G1QZL4 ^@ Function|||Subcellular Location Annotation ^@ Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.|||centriolar satellite|||cilium basal body http://togogenome.org/gene/61853:SLC10A7 ^@ http://purl.uniprot.org/uniprot/A0A2I3GG96|||http://purl.uniprot.org/uniprot/A0A2I3GHD7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Cell membrane|||Does not show transport activity towards bile acids or steroid sulfates.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/61853:MSRB3 ^@ http://purl.uniprot.org/uniprot/A0A2I3H5Y7|||http://purl.uniprot.org/uniprot/G1QSA5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit.|||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. http://togogenome.org/gene/61853:TOP2B ^@ http://purl.uniprot.org/uniprot/A0A2I3H296 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase family.|||Homodimer.|||Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.|||nucleolus|||nucleoplasm http://togogenome.org/gene/61853:DUSP13 ^@ http://purl.uniprot.org/uniprot/A0A2I3G366|||http://purl.uniprot.org/uniprot/G1S4N2 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/61853:IL1B ^@ http://purl.uniprot.org/uniprot/A0A2I3HN27 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.|||Lysosome|||Monomer. Interacts with MEFV.|||Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted|||cytosol|||extracellular exosome http://togogenome.org/gene/61853:HNRNPH1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HQA4 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/61853:BROX ^@ http://purl.uniprot.org/uniprot/M3Z9G6 ^@ Similarity ^@ Belongs to the BROX family. http://togogenome.org/gene/61853:LOC100579854 ^@ http://purl.uniprot.org/uniprot/A0A2I3HFH2|||http://purl.uniprot.org/uniprot/G1RPN9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:LOC100589309 ^@ http://purl.uniprot.org/uniprot/G1SAV9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:CHRDL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3H661 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/61853:CLDN2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GE74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/61853:PIK3R2 ^@ http://purl.uniprot.org/uniprot/G1R1V3 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/61853:COQ6 ^@ http://purl.uniprot.org/uniprot/G1S245 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UbiH/COQ6 family.|||Cell projection|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.|||FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.|||Golgi apparatus|||Mitochondrion inner membrane http://togogenome.org/gene/61853:EIF4EBP2 ^@ http://purl.uniprot.org/uniprot/G1S205 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/61853:CSNK2A1 ^@ http://purl.uniprot.org/uniprot/G1RE63 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:LIN7B ^@ http://purl.uniprot.org/uniprot/G1QYI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.|||Postsynaptic density membrane|||tight junction http://togogenome.org/gene/61853:PRIMPOL ^@ http://purl.uniprot.org/uniprot/G1RJ98 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/61853:ATG4A ^@ http://purl.uniprot.org/uniprot/A0A2I3GSB1|||http://purl.uniprot.org/uniprot/G1RV27 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/61853:ORC5 ^@ http://purl.uniprot.org/uniprot/G1RCX8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:ACVR1C ^@ http://purl.uniprot.org/uniprot/A0A2I3H7Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/61853:MAPK10 ^@ http://purl.uniprot.org/uniprot/G1RDP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/61853:TUT7 ^@ http://purl.uniprot.org/uniprot/G1QZG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B-like family.|||Cytoplasm http://togogenome.org/gene/61853:SCN3B ^@ http://purl.uniprot.org/uniprot/A0A2I3H6W0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.|||Membrane|||Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. http://togogenome.org/gene/61853:GJB5 ^@ http://purl.uniprot.org/uniprot/G1QTF6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/61853:TIPRL ^@ http://purl.uniprot.org/uniprot/G1RY09 ^@ Similarity ^@ Belongs to the TIP41 family. http://togogenome.org/gene/61853:KCNK5 ^@ http://purl.uniprot.org/uniprot/G1RKX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/61853:SNX3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GBF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome|||Endosome|||phagosome http://togogenome.org/gene/61853:PDLIM1 ^@ http://purl.uniprot.org/uniprot/G1RRJ7 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/61853:YWHAB ^@ http://purl.uniprot.org/uniprot/G1R4G7 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/61853:TRIM32 ^@ http://purl.uniprot.org/uniprot/A0A2I3GW37 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/61853:RPLP0 ^@ http://purl.uniprot.org/uniprot/G1QHI2 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL10 family.|||Ribosomal protein P0 is the functional equivalent of E.coli protein L10. http://togogenome.org/gene/61853:HSPB3 ^@ http://purl.uniprot.org/uniprot/G1SB43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/61853:LOC100598772 ^@ http://purl.uniprot.org/uniprot/A0A2I3GMV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/61853:CHGA ^@ http://purl.uniprot.org/uniprot/G1S5U4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/61853:NDUFV2 ^@ http://purl.uniprot.org/uniprot/G1R5J3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. http://togogenome.org/gene/61853:ENO1 ^@ http://purl.uniprot.org/uniprot/G1RDB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/61853:HK2 ^@ http://purl.uniprot.org/uniprot/G1QK52 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/61853:LOC100587665 ^@ http://purl.uniprot.org/uniprot/A0A2I3HER1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:KCNH8 ^@ http://purl.uniprot.org/uniprot/A0A2I3GWX5 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/61853:BCAP29 ^@ http://purl.uniprot.org/uniprot/A0A2I3HR51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||Membrane|||Plays a role in the export of secreted proteins in the ER. http://togogenome.org/gene/61853:LOC100603380 ^@ http://purl.uniprot.org/uniprot/G1RQH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||Endoplasmic reticulum http://togogenome.org/gene/61853:FSHB ^@ http://purl.uniprot.org/uniprot/G1S872 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/61853:FAM166C ^@ http://purl.uniprot.org/uniprot/G1QPU9 ^@ Similarity ^@ Belongs to the CIMIP2 family. http://togogenome.org/gene/61853:PRAF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GYW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/61853:EFHC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GWC5 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/61853:LIPM ^@ http://purl.uniprot.org/uniprot/G1RNL2 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/61853:ST6GALNAC6 ^@ http://purl.uniprot.org/uniprot/A0A2I3HG10|||http://purl.uniprot.org/uniprot/G1S6W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/61853:HSDL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GJB6 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/61853:AREG ^@ http://purl.uniprot.org/uniprot/G1R902 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:CLDN4 ^@ http://purl.uniprot.org/uniprot/G1SAN1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/61853:PGK1 ^@ http://purl.uniprot.org/uniprot/G1QNC5 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/61853:IRX2 ^@ http://purl.uniprot.org/uniprot/G1RK74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/61853:S1PR3 ^@ http://purl.uniprot.org/uniprot/G1RBJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:ING3 ^@ http://purl.uniprot.org/uniprot/A0A2I3FUM2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/61853:GNAI3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HE78 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/61853:LOC100607576 ^@ http://purl.uniprot.org/uniprot/G1S9Y6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:GLA ^@ http://purl.uniprot.org/uniprot/A0A2I3HYM3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/61853:MARK2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GR28|||http://purl.uniprot.org/uniprot/A0A2I3GR80|||http://purl.uniprot.org/uniprot/A0A2I3GZV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/61853:CCND1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GKV0 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/61853:LIN54 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBB7|||http://purl.uniprot.org/uniprot/A0A2I3HIB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-54 family.|||Nucleus http://togogenome.org/gene/61853:RO60 ^@ http://purl.uniprot.org/uniprot/A0A2I3HJ18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ro 60 kDa family.|||Cytoplasm http://togogenome.org/gene/61853:ELAVL2 ^@ http://purl.uniprot.org/uniprot/G1S300 ^@ Similarity ^@ Belongs to the RRM elav family. http://togogenome.org/gene/61853:SLC25A17 ^@ http://purl.uniprot.org/uniprot/A0A2I3HZK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/61853:IL18RAP ^@ http://purl.uniprot.org/uniprot/G1RX82 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/61853:B4GALT4 ^@ http://purl.uniprot.org/uniprot/G1QY60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/61853:NUP62CL ^@ http://purl.uniprot.org/uniprot/G1RUB9 ^@ Similarity ^@ Belongs to the nucleoporin NSP1/NUP62 family. http://togogenome.org/gene/61853:FAM228A ^@ http://purl.uniprot.org/uniprot/G1QJE2 ^@ Similarity ^@ Belongs to the FAM228 family. http://togogenome.org/gene/61853:CHST6 ^@ http://purl.uniprot.org/uniprot/G1RRF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/61853:DPF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G1Z5 ^@ Similarity ^@ Belongs to the requiem/DPF family. http://togogenome.org/gene/61853:CLCC1 ^@ http://purl.uniprot.org/uniprot/G1QNZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel MCLC family.|||Membrane http://togogenome.org/gene/61853:P2RY2 ^@ http://purl.uniprot.org/uniprot/G1S5M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:CD164 ^@ http://purl.uniprot.org/uniprot/A0A2I3H2B8|||http://purl.uniprot.org/uniprot/A0A2I3HDJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD164 family.|||Membrane http://togogenome.org/gene/61853:ARRDC3 ^@ http://purl.uniprot.org/uniprot/G1RUE0 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/61853:RPL39L ^@ http://purl.uniprot.org/uniprot/A0A2I3HXY3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/61853:IREB2 ^@ http://purl.uniprot.org/uniprot/G1RBD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Cytoplasm http://togogenome.org/gene/61853:TYRP1 ^@ http://purl.uniprot.org/uniprot/G1S7E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/61853:LIPN ^@ http://purl.uniprot.org/uniprot/G1RNK6 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/61853:EN2 ^@ http://purl.uniprot.org/uniprot/G1RZJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Engrailed homeobox family.|||Nucleus http://togogenome.org/gene/61853:TLX1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HWY1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:IL36RN ^@ http://purl.uniprot.org/uniprot/G1QN77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/61853:NUBP2 ^@ http://purl.uniprot.org/uniprot/G1RBW2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.|||Nucleus|||centrosome http://togogenome.org/gene/61853:CLDN11 ^@ http://purl.uniprot.org/uniprot/G1QZK3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/61853:VEZT ^@ http://purl.uniprot.org/uniprot/A0A2I3G3X9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vezatin family.|||Cell membrane|||Membrane|||Nucleus|||adherens junction http://togogenome.org/gene/61853:SUPT16H ^@ http://purl.uniprot.org/uniprot/G1RWD0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24 family. SPT16 subfamily.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Component of the FACT complex.|||Nucleus http://togogenome.org/gene/61853:KRT6C ^@ http://purl.uniprot.org/uniprot/A0A2I3H0V3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/61853:DTX3L ^@ http://purl.uniprot.org/uniprot/A0A2I3H139 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/61853:UGGT1 ^@ http://purl.uniprot.org/uniprot/G1S1F4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 8 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/61853:ABT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF2/ABP1 family.|||nucleolus http://togogenome.org/gene/61853:ETV5 ^@ http://purl.uniprot.org/uniprot/G1R425 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/61853:PBX2 ^@ http://purl.uniprot.org/uniprot/G1R4E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/61853:SLC26A11 ^@ http://purl.uniprot.org/uniprot/G1S0J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/61853:PGM1 ^@ http://purl.uniprot.org/uniprot/G1RYM2 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/61853:VHL ^@ http://purl.uniprot.org/uniprot/G1QWL9 ^@ Similarity ^@ Belongs to the VHL family. http://togogenome.org/gene/61853:SLC35B3 ^@ http://purl.uniprot.org/uniprot/A0A2I3G7H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/61853:ATP6V1F ^@ http://purl.uniprot.org/uniprot/A0A2I3HWZ2|||http://purl.uniprot.org/uniprot/G1RPE0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase F subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/61853:C17H6orf89 ^@ http://purl.uniprot.org/uniprot/A0A2I3FPD6|||http://purl.uniprot.org/uniprot/A0A2I3H3Y9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:ZNF408 ^@ http://purl.uniprot.org/uniprot/G1RVA2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:IFI27L2 ^@ http://purl.uniprot.org/uniprot/G1S611 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/61853:FOXH1 ^@ http://purl.uniprot.org/uniprot/G1RIV3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:TINAGL1 ^@ http://purl.uniprot.org/uniprot/G1QN12 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/61853:LOC100606450 ^@ http://purl.uniprot.org/uniprot/A0A2I3G1C6 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/61853:MAB21L2 ^@ http://purl.uniprot.org/uniprot/G1SAJ5 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/61853:KLHL3 ^@ http://purl.uniprot.org/uniprot/G1RAX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KLHL3 family.|||cytoskeleton|||cytosol http://togogenome.org/gene/61853:SLITRK4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HJG8 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/61853:STARD6 ^@ http://purl.uniprot.org/uniprot/G1RMN0 ^@ Function ^@ May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols. http://togogenome.org/gene/61853:CEBPE ^@ http://purl.uniprot.org/uniprot/G1RY61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/61853:SETD7 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.|||Chromosome|||Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.|||Nucleus http://togogenome.org/gene/61853:SNX7 ^@ http://purl.uniprot.org/uniprot/G1RKY2 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/61853:LOC100593203 ^@ http://purl.uniprot.org/uniprot/G1S9R7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:ARPC1A ^@ http://purl.uniprot.org/uniprot/G1RJF2 ^@ Function|||Similarity ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. http://togogenome.org/gene/61853:TTR ^@ http://purl.uniprot.org/uniprot/G1R3S8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transthyretin family.|||Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.|||Secreted|||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. http://togogenome.org/gene/61853:MRPL3 ^@ http://purl.uniprot.org/uniprot/A0A2I3H315 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/61853:GPATCH1 ^@ http://purl.uniprot.org/uniprot/G1R7Z8 ^@ Similarity ^@ Belongs to the GPATCH1 family. http://togogenome.org/gene/61853:NDC80 ^@ http://purl.uniprot.org/uniprot/G1R5A2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NDC80/HEC1 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/61853:LOC100602058 ^@ http://purl.uniprot.org/uniprot/A0A2I3HJM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/61853:SNX10 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBN1|||http://purl.uniprot.org/uniprot/G1RY44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/61853:HOOK3 ^@ http://purl.uniprot.org/uniprot/A0A2I3G802 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hook family.|||cytoskeleton http://togogenome.org/gene/61853:CSF2 ^@ http://purl.uniprot.org/uniprot/G1RQ20 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GM-CSF family.|||Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.|||Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.|||Secreted http://togogenome.org/gene/61853:MLEC ^@ http://purl.uniprot.org/uniprot/A0A2I3GH34|||http://purl.uniprot.org/uniprot/A0A2I3HCL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the malectin family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:DTNBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GC51 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/61853:DERL1 ^@ http://purl.uniprot.org/uniprot/G1QZD6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/61853:VAPB ^@ http://purl.uniprot.org/uniprot/A0A2I3FQK8|||http://purl.uniprot.org/uniprot/G1RDT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:CHSY3 ^@ http://purl.uniprot.org/uniprot/G1RPC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/61853:PIGZ ^@ http://purl.uniprot.org/uniprot/G1QMF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:SUV39H2 ^@ http://purl.uniprot.org/uniprot/G1RN95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.|||Nucleus|||centromere http://togogenome.org/gene/61853:CDO1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G8L2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the cysteine dioxygenase family.|||Binds 1 Fe cation per subunit.|||Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen. http://togogenome.org/gene/61853:NUDT6 ^@ http://purl.uniprot.org/uniprot/A0A2I3FPU2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family.|||Cytoplasm|||May contribute to the regulation of cell proliferation.|||Mitochondrion|||Monomer and homodimer.|||Nucleus http://togogenome.org/gene/61853:BABAM2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GAP1|||http://purl.uniprot.org/uniprot/G1RZ93 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BABAM2 family.|||Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.|||Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.|||Cytoplasm|||May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.|||Nucleus http://togogenome.org/gene/61853:HSPA13 ^@ http://purl.uniprot.org/uniprot/G1QML3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Binds UBQLN2.|||Endoplasmic reticulum|||Has peptide-independent ATPase activity.|||Microsome http://togogenome.org/gene/61853:MEP1B ^@ http://purl.uniprot.org/uniprot/G1R3K9 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:LOC105739943 ^@ http://purl.uniprot.org/uniprot/G1SB56 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:DAG1 ^@ http://purl.uniprot.org/uniprot/G1R572 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.|||Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.|||cytoskeleton|||extracellular space|||nucleoplasm|||sarcolemma http://togogenome.org/gene/61853:RUVBL1 ^@ http://purl.uniprot.org/uniprot/G1RVN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||Dynein axonemal particle|||Nucleus|||Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. http://togogenome.org/gene/61853:LOC100595527 ^@ http://purl.uniprot.org/uniprot/A0A2I3H8U1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:MAP3K11 ^@ http://purl.uniprot.org/uniprot/G1R178 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Homodimer.|||Homodimerization via the leucine zipper domains is required for autophosphorylation. http://togogenome.org/gene/61853:ACO1 ^@ http://purl.uniprot.org/uniprot/G1QTE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Cytoplasm http://togogenome.org/gene/61853:CTPS2 ^@ http://purl.uniprot.org/uniprot/G1REF4 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/61853:CASS4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HVS9|||http://purl.uniprot.org/uniprot/G1R5V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/61853:EPN1 ^@ http://purl.uniprot.org/uniprot/G1RI64 ^@ Similarity ^@ Belongs to the epsin family. http://togogenome.org/gene/61853:MS4A6A ^@ http://purl.uniprot.org/uniprot/G1RSC2 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/61853:TAS2R50 ^@ http://purl.uniprot.org/uniprot/G1SA71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/61853:NEFL ^@ http://purl.uniprot.org/uniprot/G1S1T9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/61853:LOC100600196 ^@ http://purl.uniprot.org/uniprot/A0A2I3G8J0 ^@ Similarity ^@ Belongs to the histone H2B family. http://togogenome.org/gene/61853:NMUR2 ^@ http://purl.uniprot.org/uniprot/G1S3C6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/61853:UVSSA ^@ http://purl.uniprot.org/uniprot/G1QK36 ^@ Similarity ^@ Belongs to the UVSSA family. http://togogenome.org/gene/61853:DDX6 ^@ http://purl.uniprot.org/uniprot/G1R720 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/61853:ELOVL5 ^@ http://purl.uniprot.org/uniprot/G1QTK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL5 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||dendrite http://togogenome.org/gene/61853:TAS2R13 ^@ http://purl.uniprot.org/uniprot/G1QT86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/61853:MRPS21 ^@ http://purl.uniprot.org/uniprot/A0A2I3GDL4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/61853:ATP5PB ^@ http://purl.uniprot.org/uniprot/G1QV65 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ATPase B chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/61853:TSPAN31 ^@ http://purl.uniprot.org/uniprot/G1S5X0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/61853:NUDCD1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GNR5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/61853:PCNP ^@ http://purl.uniprot.org/uniprot/A0A2I3GYR5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with UHRF2/NIRF.|||May be involved in cell cycle regulation.|||Nucleus http://togogenome.org/gene/61853:GABARAPL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GXJ2 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/61853:CHM ^@ http://purl.uniprot.org/uniprot/G1QR06 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. http://togogenome.org/gene/61853:ODAM ^@ http://purl.uniprot.org/uniprot/G1R7Z0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ODAM family.|||Cytoplasm|||Interacts (via C-terminus) with ARHGEF5.|||Nucleus|||Secreted|||Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface. http://togogenome.org/gene/61853:GK ^@ http://purl.uniprot.org/uniprot/A0A2I3FWY7|||http://purl.uniprot.org/uniprot/A0A2I3HMK9|||http://purl.uniprot.org/uniprot/G1RGH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FGGY kinase family.|||Cytoplasm http://togogenome.org/gene/61853:PRKAB2 ^@ http://purl.uniprot.org/uniprot/G1QH07 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/61853:ADAM12 ^@ http://purl.uniprot.org/uniprot/G1QJE1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:LOC100591157 ^@ http://purl.uniprot.org/uniprot/G1R9H0 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/61853:GCSH ^@ http://purl.uniprot.org/uniprot/A0A2I3GIN5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/61853:ZDHHC16 ^@ http://purl.uniprot.org/uniprot/A0A2I3G341|||http://purl.uniprot.org/uniprot/A0A2I3GMJ0|||http://purl.uniprot.org/uniprot/G1RUQ2 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/61853:MC2R ^@ http://purl.uniprot.org/uniprot/A0A2I3GEJ5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).|||Membrane http://togogenome.org/gene/61853:UTP3 ^@ http://purl.uniprot.org/uniprot/G1SAB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAS10 family.|||nucleolus http://togogenome.org/gene/61853:RPAP2 ^@ http://purl.uniprot.org/uniprot/G1RHM8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.|||Belongs to the RPAP2 family.|||Nucleus|||Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. http://togogenome.org/gene/61853:EBAG9 ^@ http://purl.uniprot.org/uniprot/A0A2I3HUX3 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. http://togogenome.org/gene/61853:GTPBP8 ^@ http://purl.uniprot.org/uniprot/A0A2I3GXL5 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. http://togogenome.org/gene/61853:PPP1R14B ^@ http://purl.uniprot.org/uniprot/G1QYA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PP1 inhibitor family.|||Cytoplasm|||Inhibitor of PPP1CA. http://togogenome.org/gene/61853:SNRPA1 ^@ http://purl.uniprot.org/uniprot/G1QI33 ^@ Similarity ^@ Belongs to the U2 small nuclear ribonucleoprotein A family. http://togogenome.org/gene/61853:MLH3 ^@ http://purl.uniprot.org/uniprot/A0A2I3FYF7|||http://purl.uniprot.org/uniprot/G1S353 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/61853:GPSM2 ^@ http://purl.uniprot.org/uniprot/G1QNT0 ^@ Similarity ^@ Belongs to the GPSM family. http://togogenome.org/gene/61853:ADAM10 ^@ http://purl.uniprot.org/uniprot/A0A2I3G1N0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:HOXD4 ^@ http://purl.uniprot.org/uniprot/G1R255 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/61853:GABRR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GI15|||http://purl.uniprot.org/uniprot/A0A2I3GMK6|||http://purl.uniprot.org/uniprot/G1RRN1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/61853:MRPS33 ^@ http://purl.uniprot.org/uniprot/G1QP68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS33 family.|||Mitochondrion http://togogenome.org/gene/61853:HSD3B2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G3G6 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/61853:MZF1 ^@ http://purl.uniprot.org/uniprot/G1RK99 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:PRAMEF14 ^@ http://purl.uniprot.org/uniprot/G1RFN0 ^@ Similarity ^@ Belongs to the PRAME family. http://togogenome.org/gene/61853:LOC100597977 ^@ http://purl.uniprot.org/uniprot/A0A2I3GFP7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:STOM ^@ http://purl.uniprot.org/uniprot/A0A2I3GGF0 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/61853:FAM162A ^@ http://purl.uniprot.org/uniprot/G1QHF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0389 family.|||Membrane http://togogenome.org/gene/61853:SRP19 ^@ http://purl.uniprot.org/uniprot/A0A2I3HU51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP19 family.|||Cytoplasm http://togogenome.org/gene/61853:MINDY3 ^@ http://purl.uniprot.org/uniprot/G1RPC6 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/61853:TMPRSS11A ^@ http://purl.uniprot.org/uniprot/G1RD87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/61853:NCOA3 ^@ http://purl.uniprot.org/uniprot/G1R5G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/61853:COX2 ^@ http://purl.uniprot.org/uniprot/D4QAT8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:GRID2 ^@ http://purl.uniprot.org/uniprot/G1RVW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/61853:NR2E1 ^@ http://purl.uniprot.org/uniprot/G1RTH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/61853:GLCE ^@ http://purl.uniprot.org/uniprot/G1RSR8 ^@ Similarity ^@ Belongs to the D-glucuronyl C5-epimerase family. http://togogenome.org/gene/61853:CHRM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G6E5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/61853:LOC100599631 ^@ http://purl.uniprot.org/uniprot/A0A2I3GYJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX15/CtaA family.|||Membrane http://togogenome.org/gene/61853:HMMR ^@ http://purl.uniprot.org/uniprot/A0A2I3GR02|||http://purl.uniprot.org/uniprot/A0A2I3HW09|||http://purl.uniprot.org/uniprot/G1QXW0 ^@ Subcellular Location Annotation ^@ spindle http://togogenome.org/gene/61853:TNFSF12 ^@ http://purl.uniprot.org/uniprot/A0A2I3GUT7 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/61853:RPN1 ^@ http://purl.uniprot.org/uniprot/G1RW20 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/61853:LOC100605657 ^@ http://purl.uniprot.org/uniprot/A0A2I3HWQ4|||http://purl.uniprot.org/uniprot/G1S5F1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/61853:TMEM182 ^@ http://purl.uniprot.org/uniprot/G1RXC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM182 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:TENT5B ^@ http://purl.uniprot.org/uniprot/G1RE21 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/61853:HSP90B1 ^@ http://purl.uniprot.org/uniprot/G1R417 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 90 family.|||Melanosome http://togogenome.org/gene/61853:SMIM12 ^@ http://purl.uniprot.org/uniprot/G1S9B7|||http://purl.uniprot.org/uniprot/G1S9B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM12 family.|||Membrane http://togogenome.org/gene/61853:MMP12 ^@ http://purl.uniprot.org/uniprot/G1R6D8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/61853:SFPQ ^@ http://purl.uniprot.org/uniprot/A0A2I3GVW0 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/61853:TOMM20 ^@ http://purl.uniprot.org/uniprot/A0A2I3H7P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom20 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/61853:RABAC1 ^@ http://purl.uniprot.org/uniprot/G1RST1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/61853:ANO6 ^@ http://purl.uniprot.org/uniprot/A0A2I3HGP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:ZNF394 ^@ http://purl.uniprot.org/uniprot/A0A2I3GIN9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:VRK1 ^@ http://purl.uniprot.org/uniprot/G1QIR9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:LOC100590665 ^@ http://purl.uniprot.org/uniprot/G1R675 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/61853:NLK ^@ http://purl.uniprot.org/uniprot/G1QMQ8 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/61853:TP53BP2 ^@ http://purl.uniprot.org/uniprot/G1RSK7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:GABBR2 ^@ http://purl.uniprot.org/uniprot/G1S578 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:EBPL ^@ http://purl.uniprot.org/uniprot/A0A2I3GKR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:MCHR1 ^@ http://purl.uniprot.org/uniprot/G1RZH5 ^@ Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Interacts with NCDN.|||Membrane http://togogenome.org/gene/61853:ETV6 ^@ http://purl.uniprot.org/uniprot/G1QTB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/61853:HSPB7 ^@ http://purl.uniprot.org/uniprot/G1R7Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/61853:COQ3 ^@ http://purl.uniprot.org/uniprot/G1RTK7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Mitochondrion inner membrane|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. http://togogenome.org/gene/61853:IL33 ^@ http://purl.uniprot.org/uniprot/G1RD14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family. Highly divergent.|||Chromosome|||Nucleus|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/61853:ARPC4 ^@ http://purl.uniprot.org/uniprot/G1QVW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARPC4 family.|||Cell projection|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.|||cytoskeleton http://togogenome.org/gene/61853:TMEM14A ^@ http://purl.uniprot.org/uniprot/A0A2I3HRX6 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/61853:MANEAL ^@ http://purl.uniprot.org/uniprot/G1RLR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:ODF1 ^@ http://purl.uniprot.org/uniprot/G1QTW7 ^@ Function ^@ Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. http://togogenome.org/gene/61853:VWC2L ^@ http://purl.uniprot.org/uniprot/G1R6G4 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/61853:TTC4 ^@ http://purl.uniprot.org/uniprot/G1QS80 ^@ Similarity ^@ Belongs to the TTC4 family. http://togogenome.org/gene/61853:CD44 ^@ http://purl.uniprot.org/uniprot/A0A2I3GL26|||http://purl.uniprot.org/uniprot/A0A2I3GMY1|||http://purl.uniprot.org/uniprot/A0A2I3GQ93|||http://purl.uniprot.org/uniprot/G1S8E6|||http://purl.uniprot.org/uniprot/M3Z972 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||microvillus http://togogenome.org/gene/61853:LOC100602422 ^@ http://purl.uniprot.org/uniprot/A0A2I3GE69 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/61853:GOLM1 ^@ http://purl.uniprot.org/uniprot/G1QUE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLM family.|||Membrane http://togogenome.org/gene/61853:MRPL44 ^@ http://purl.uniprot.org/uniprot/A0A2I3GG57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.|||Mitochondrion http://togogenome.org/gene/61853:LOC100607085 ^@ http://purl.uniprot.org/uniprot/A0A2I3HE97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine gamma family.|||Secreted http://togogenome.org/gene/61853:DNASE1L1 ^@ http://purl.uniprot.org/uniprot/G1RVD0 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/61853:LOC100602869 ^@ http://purl.uniprot.org/uniprot/G1S7S2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/61853:THOC7 ^@ http://purl.uniprot.org/uniprot/G1RM39 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC7 family.|||Nucleus|||Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. http://togogenome.org/gene/61853:KDM4C ^@ http://purl.uniprot.org/uniprot/M3Z927 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM3 histone demethylase family.|||Nucleus http://togogenome.org/gene/61853:OGDH ^@ http://purl.uniprot.org/uniprot/A0A2I3GT55 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/61853:SLC6A2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GAK2|||http://purl.uniprot.org/uniprot/G1QLA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/61853:NUDT21 ^@ http://purl.uniprot.org/uniprot/G1QN95 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family. CPSF5 subfamily.|||Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.|||Cytoplasm|||Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.|||Nucleus http://togogenome.org/gene/61853:DGUOK ^@ http://purl.uniprot.org/uniprot/A0A2I3I0A1 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/61853:MLLT3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HQI2|||http://purl.uniprot.org/uniprot/G1S6X8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:CD93 ^@ http://purl.uniprot.org/uniprot/G1RLD8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:KIAA1324L ^@ http://purl.uniprot.org/uniprot/G1RY17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELAPOR family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:LOC115830347 ^@ http://purl.uniprot.org/uniprot/A0A2I3G9P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COA8 family.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:PDE8A ^@ http://purl.uniprot.org/uniprot/G1RK33 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/61853:TPH2 ^@ http://purl.uniprot.org/uniprot/G1QWY3 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/61853:HPS6 ^@ http://purl.uniprot.org/uniprot/G1SBR6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with AP-3 complex.|||May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.|||Microsome membrane http://togogenome.org/gene/61853:CXCL2 ^@ http://purl.uniprot.org/uniprot/G1R8Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/61853:PACSIN1 ^@ http://purl.uniprot.org/uniprot/G1RAD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PACSIN family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||cytosol|||ruffle membrane|||synaptosome http://togogenome.org/gene/61853:HPS3 ^@ http://purl.uniprot.org/uniprot/G1QRA2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.|||Cytoplasm|||Involved in early stages of melanosome biogenesis and maturation. http://togogenome.org/gene/61853:FUCA1 ^@ http://purl.uniprot.org/uniprot/G1RBV2 ^@ Function|||Similarity|||Subunit ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family.|||Homotetramer. http://togogenome.org/gene/61853:LDLRAD4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GE96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMEPA1 family.|||Early endosome membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/61853:MED20 ^@ http://purl.uniprot.org/uniprot/A0A2I3G1W6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 20 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/61853:MIPEP ^@ http://purl.uniprot.org/uniprot/A0A2I3GF84 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/61853:PRPF4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GKW2 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/61853:NUDT2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GL45 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/61853:AZIN1 ^@ http://purl.uniprot.org/uniprot/G1QU14 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/61853:PML ^@ http://purl.uniprot.org/uniprot/A0A2I3GV99|||http://purl.uniprot.org/uniprot/A0A2I3HQ50|||http://purl.uniprot.org/uniprot/G1RW42|||http://purl.uniprot.org/uniprot/Q15JD7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:NUP93 ^@ http://purl.uniprot.org/uniprot/G1QPW6|||http://purl.uniprot.org/uniprot/M3ZCF1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin interacting component (NIC) family.|||Nucleus membrane|||Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.|||nuclear pore complex http://togogenome.org/gene/61853:GTF2H4 ^@ http://purl.uniprot.org/uniprot/G1R0S8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.|||Nucleus http://togogenome.org/gene/61853:GLYATL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GHL9 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/61853:TRMT5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GXC9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM5 / TYW2 family.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Mitochondrion matrix|||Monomer.|||Nucleus|||Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. http://togogenome.org/gene/61853:NSMCE2 ^@ http://purl.uniprot.org/uniprot/G1R0K2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NSE2 family.|||Nucleus http://togogenome.org/gene/61853:GPM6A ^@ http://purl.uniprot.org/uniprot/A0A2I3G7P4|||http://purl.uniprot.org/uniprot/A0A2I3H4I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/61853:NAGA ^@ http://purl.uniprot.org/uniprot/G1S0X4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/61853:HMX3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HYL0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:DPY30 ^@ http://purl.uniprot.org/uniprot/A0A2I3GIG7 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/61853:GALNT1 ^@ http://purl.uniprot.org/uniprot/G1R326 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:CNTNAP4 ^@ http://purl.uniprot.org/uniprot/G1RRS8 ^@ Caution|||Similarity ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:CD82 ^@ http://purl.uniprot.org/uniprot/A0A2I3G9N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/61853:COQ4 ^@ http://purl.uniprot.org/uniprot/G1S722 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ4 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:IRF5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GUB4|||http://purl.uniprot.org/uniprot/G1RPJ8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:SERPING1 ^@ http://purl.uniprot.org/uniprot/G1RQM7 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/61853:PSMA5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GAD4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/61853:DDOST ^@ http://purl.uniprot.org/uniprot/A0A2I3HIP2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DDOST 48 kDa subunit family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). http://togogenome.org/gene/61853:LOC100599068 ^@ http://purl.uniprot.org/uniprot/G1S9T1 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:RNF20 ^@ http://purl.uniprot.org/uniprot/G1S5M8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BRE1 family.|||Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.|||Nucleus http://togogenome.org/gene/61853:DSC3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HMK5 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/61853:AP3M1 ^@ http://purl.uniprot.org/uniprot/G1S4J0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. http://togogenome.org/gene/61853:SLC1A2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GBH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/61853:ZSCAN16 ^@ http://purl.uniprot.org/uniprot/G1QWT8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:ERH ^@ http://purl.uniprot.org/uniprot/G1QLG4 ^@ Function|||Similarity ^@ Belongs to the E(R) family.|||May have a role in the cell cycle. http://togogenome.org/gene/61853:PROKR2 ^@ http://purl.uniprot.org/uniprot/G1R865 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:LOC100587245 ^@ http://purl.uniprot.org/uniprot/A0A2I3HNS8 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/61853:ADSS2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GZL0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Mitochondrion|||Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.|||Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. http://togogenome.org/gene/61853:WIF1 ^@ http://purl.uniprot.org/uniprot/G1QS54 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:NT5C3A ^@ http://purl.uniprot.org/uniprot/G1RZN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/61853:ITGB1 ^@ http://purl.uniprot.org/uniprot/G1S945 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:DHDDS ^@ http://purl.uniprot.org/uniprot/A0A2I3HM77|||http://purl.uniprot.org/uniprot/G1RDN6 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/61853:DGAT2L6 ^@ http://purl.uniprot.org/uniprot/G1QJ34 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:CXCL10 ^@ http://purl.uniprot.org/uniprot/G1R9F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/61853:NPC2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HN70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPC2 family.|||Secreted http://togogenome.org/gene/61853:LOC100582240 ^@ http://purl.uniprot.org/uniprot/G1RNH5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/61853:LOC100603983 ^@ http://purl.uniprot.org/uniprot/G1SA62 ^@ Function|||Subunit ^@ In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/61853:FOPNL ^@ http://purl.uniprot.org/uniprot/G1QGT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP43 family.|||centriole|||cilium basal body http://togogenome.org/gene/61853:RAD9B ^@ http://purl.uniprot.org/uniprot/G1QRV7 ^@ Similarity ^@ Belongs to the rad9 family. http://togogenome.org/gene/61853:SDHAF4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HE54 ^@ Similarity ^@ Belongs to the SDHAF4 family. http://togogenome.org/gene/61853:OLFML1 ^@ http://purl.uniprot.org/uniprot/G1S6T6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:GDF7 ^@ http://purl.uniprot.org/uniprot/G1QQG7 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/61853:ALAS1 ^@ http://purl.uniprot.org/uniprot/G1R616 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:MFSD4B ^@ http://purl.uniprot.org/uniprot/A0A2I3GW71 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:TAF11 ^@ http://purl.uniprot.org/uniprot/A0A2I3GVT0|||http://purl.uniprot.org/uniprot/G1RAS1 ^@ Similarity ^@ Belongs to the TAF11 family. http://togogenome.org/gene/61853:HOXA6 ^@ http://purl.uniprot.org/uniprot/G1RY96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/61853:LOC100586327 ^@ http://purl.uniprot.org/uniprot/A0A2I3FPQ7|||http://purl.uniprot.org/uniprot/A0A2I3HAX4 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/61853:KNG1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GVD0|||http://purl.uniprot.org/uniprot/A0A2I3HH60|||http://purl.uniprot.org/uniprot/G1R4E4 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/61853:TRMT6 ^@ http://purl.uniprot.org/uniprot/G1RUN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM6/GCD10 family.|||Heterotetramer.|||Nucleus|||Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. http://togogenome.org/gene/61853:NEO1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GTR8|||http://purl.uniprot.org/uniprot/A0A2I3HW62|||http://purl.uniprot.org/uniprot/G1RVI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. DCC family.|||Membrane http://togogenome.org/gene/61853:TRDN ^@ http://purl.uniprot.org/uniprot/A0A2I3FSH3|||http://purl.uniprot.org/uniprot/A0A2I3H785|||http://purl.uniprot.org/uniprot/G1RUE8 ^@ Subcellular Location Annotation ^@ Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/61853:MCM8 ^@ http://purl.uniprot.org/uniprot/A0A2I3G2S4|||http://purl.uniprot.org/uniprot/A0A2I3GDI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/61853:LIF ^@ http://purl.uniprot.org/uniprot/G1QTI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LIF/OSM family.|||LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.|||Secreted http://togogenome.org/gene/61853:SNRPG ^@ http://purl.uniprot.org/uniprot/G1RGQ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/61853:DTD2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G2X1 ^@ Similarity ^@ Belongs to the DTD family. http://togogenome.org/gene/61853:SERPINA6 ^@ http://purl.uniprot.org/uniprot/G1S630 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/61853:FAM13A ^@ http://purl.uniprot.org/uniprot/A0A2I3GGW3|||http://purl.uniprot.org/uniprot/A0A2I3GH50|||http://purl.uniprot.org/uniprot/A0A2I3I090 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/61853:CERS2 ^@ http://purl.uniprot.org/uniprot/G1RG72 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/61853:PPP4R3B ^@ http://purl.uniprot.org/uniprot/A0A2I3GK52|||http://purl.uniprot.org/uniprot/A0A2I3H7Q6 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/61853:MRPL51 ^@ http://purl.uniprot.org/uniprot/A0A2I3G3J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL51 family.|||Mitochondrion http://togogenome.org/gene/61853:C18H10orf53 ^@ http://purl.uniprot.org/uniprot/A0A2I3GU87 ^@ Similarity ^@ Belongs to the UPF0728 family. http://togogenome.org/gene/61853:RIC3 ^@ http://purl.uniprot.org/uniprot/A0A2I3H766 ^@ Similarity ^@ Belongs to the ric-3 family. http://togogenome.org/gene/61853:OTOP1 ^@ http://purl.uniprot.org/uniprot/G1S271 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:ODC1 ^@ http://purl.uniprot.org/uniprot/G1RU71 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/61853:DLK2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HJM8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:ITGA9 ^@ http://purl.uniprot.org/uniprot/A0A2I3HRX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/61853:SAP30L ^@ http://purl.uniprot.org/uniprot/G1S3M0 ^@ Similarity ^@ Belongs to the SAP30 family. http://togogenome.org/gene/61853:SLC2A8 ^@ http://purl.uniprot.org/uniprot/G1S6M4 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/61853:ACTR1A ^@ http://purl.uniprot.org/uniprot/G1RYT8 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/61853:ITPR2 ^@ http://purl.uniprot.org/uniprot/G1QZX2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the InsP3 receptor family.|||Endoplasmic reticulum membrane|||Homotetramer.|||Membrane|||Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.|||The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. http://togogenome.org/gene/61853:C5H1orf74 ^@ http://purl.uniprot.org/uniprot/G1QN20 ^@ Similarity ^@ Belongs to the UPF0739 family. http://togogenome.org/gene/61853:NPFFR1 ^@ http://purl.uniprot.org/uniprot/G1S1Z5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/61853:NIPAL2 ^@ http://purl.uniprot.org/uniprot/G1QQJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/61853:LOC100593118 ^@ http://purl.uniprot.org/uniprot/A0A2I3HZK5 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/61853:IDO2 ^@ http://purl.uniprot.org/uniprot/G1RPS9 ^@ Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family. http://togogenome.org/gene/61853:MRFAP1 ^@ http://purl.uniprot.org/uniprot/G1RM71 ^@ Similarity ^@ Belongs to the MORF4 family-associated protein family. http://togogenome.org/gene/61853:SPRTN ^@ http://purl.uniprot.org/uniprot/G1QNM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Spartan family.|||Chromosome|||Nucleus http://togogenome.org/gene/61853:VPS33B ^@ http://purl.uniprot.org/uniprot/G1RNY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Early endosome|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||clathrin-coated vesicle http://togogenome.org/gene/61853:EGFLAM ^@ http://purl.uniprot.org/uniprot/A0A2I3GPH3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:ATF1 ^@ http://purl.uniprot.org/uniprot/G1S7W8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:LOC100581135 ^@ http://purl.uniprot.org/uniprot/A0A2I3HUK9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat HIR1 family.|||Nucleus|||Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle. http://togogenome.org/gene/61853:DPH3 ^@ http://purl.uniprot.org/uniprot/A0A2I3FWQ7|||http://purl.uniprot.org/uniprot/A0A2I3GTW2 ^@ Similarity ^@ Belongs to the DPH3 family. http://togogenome.org/gene/61853:TMEM35B ^@ http://purl.uniprot.org/uniprot/G1QTI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/61853:EXOSC8 ^@ http://purl.uniprot.org/uniprot/G1QMJ8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:SLC51A ^@ http://purl.uniprot.org/uniprot/G1QL25 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:TAP1 ^@ http://purl.uniprot.org/uniprot/G1R4V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.|||Membrane http://togogenome.org/gene/61853:ARRB2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HNF6 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/61853:HAT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GP06 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HAT1 family.|||Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.|||Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). http://togogenome.org/gene/61853:CSN3 ^@ http://purl.uniprot.org/uniprot/G1R800 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the kappa-casein family.|||Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.|||Secreted http://togogenome.org/gene/61853:WDR48 ^@ http://purl.uniprot.org/uniprot/G1R0H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR48 family.|||Late endosome http://togogenome.org/gene/61853:RTCB ^@ http://purl.uniprot.org/uniprot/G1QYT2 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Catalytic component of the tRNA-splicing ligase complex.|||Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.|||Cytoplasm|||Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP. http://togogenome.org/gene/61853:INIP ^@ http://purl.uniprot.org/uniprot/G1S3J3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SOSS-C family.|||Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).|||Component of the SOSS complex.|||Nucleus http://togogenome.org/gene/61853:CERS6 ^@ http://purl.uniprot.org/uniprot/G1QX90 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/61853:NRXN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3G2N0|||http://purl.uniprot.org/uniprot/G1S4G4|||http://purl.uniprot.org/uniprot/G1S4H6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Presynaptic cell membrane http://togogenome.org/gene/61853:ISM1 ^@ http://purl.uniprot.org/uniprot/G1RWP6 ^@ Similarity ^@ Belongs to the isthmin family. http://togogenome.org/gene/61853:KCTD20 ^@ http://purl.uniprot.org/uniprot/M3ZB06 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:DRGX ^@ http://purl.uniprot.org/uniprot/A0A2I3H9V9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:NRTN ^@ http://purl.uniprot.org/uniprot/G1RTZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/61853:MMP27 ^@ http://purl.uniprot.org/uniprot/G1R6B5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/61853:TINAG ^@ http://purl.uniprot.org/uniprot/G1QT07 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/61853:SLC25A36 ^@ http://purl.uniprot.org/uniprot/G1QX13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/61853:SLC25A18 ^@ http://purl.uniprot.org/uniprot/G1R8J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/61853:PPIL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GBL8 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/61853:LOC100601682 ^@ http://purl.uniprot.org/uniprot/G1QT77 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCR10/QCR9 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:CRP ^@ http://purl.uniprot.org/uniprot/G1RS43 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:NDUFB1 ^@ http://purl.uniprot.org/uniprot/G1S5L7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:UFD1 ^@ http://purl.uniprot.org/uniprot/G1R032 ^@ Similarity ^@ Belongs to the UFD1 family. http://togogenome.org/gene/61853:MED21 ^@ http://purl.uniprot.org/uniprot/A0A2I3G1U2|||http://purl.uniprot.org/uniprot/G1R051 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 21 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/61853:MGMT ^@ http://purl.uniprot.org/uniprot/G1QLG0 ^@ Function|||Similarity ^@ Belongs to the MGMT family.|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. http://togogenome.org/gene/61853:RPL15 ^@ http://purl.uniprot.org/uniprot/A0A2I3G2C0|||http://purl.uniprot.org/uniprot/G1QTQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL15 family.|||Cytoplasm http://togogenome.org/gene/61853:PEA15 ^@ http://purl.uniprot.org/uniprot/A0A2I3HKB1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:PRAMEF19 ^@ http://purl.uniprot.org/uniprot/G1RFN2 ^@ Similarity ^@ Belongs to the PRAME family. http://togogenome.org/gene/61853:ERAL1 ^@ http://purl.uniprot.org/uniprot/G1QS33 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Membrane|||Mitochondrion inner membrane|||Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly. http://togogenome.org/gene/61853:YWHAZ ^@ http://purl.uniprot.org/uniprot/A0A2I3GBB0 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/61853:LOC100580376 ^@ http://purl.uniprot.org/uniprot/A0A2I3HF62|||http://purl.uniprot.org/uniprot/A0A2I3HJ70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/61853:LOC100581890 ^@ http://purl.uniprot.org/uniprot/G1S3W7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG10 glucosyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:DEFA6 ^@ http://purl.uniprot.org/uniprot/G1RY39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-defensin family.|||Secreted http://togogenome.org/gene/61853:B3GNT5 ^@ http://purl.uniprot.org/uniprot/G1SBB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:VLDLR ^@ http://purl.uniprot.org/uniprot/G1RBJ9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:SLC25A5 ^@ http://purl.uniprot.org/uniprot/G1RXU9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/61853:WDR44 ^@ http://purl.uniprot.org/uniprot/G1RXK1 ^@ Subcellular Location Annotation ^@ trans-Golgi network http://togogenome.org/gene/61853:ZDHHC8 ^@ http://purl.uniprot.org/uniprot/A0A2I3FRR9|||http://purl.uniprot.org/uniprot/A0A2I3HZQ0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/61853:NPHS2 ^@ http://purl.uniprot.org/uniprot/A0A2I3FW22|||http://purl.uniprot.org/uniprot/G1S0Q6 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/61853:LOC100602956 ^@ http://purl.uniprot.org/uniprot/A0A2I3GNX5 ^@ Similarity ^@ Belongs to the histone H2B family. http://togogenome.org/gene/61853:ERG ^@ http://purl.uniprot.org/uniprot/A0A2I3G7C8|||http://purl.uniprot.org/uniprot/A0A2I3HJ74|||http://purl.uniprot.org/uniprot/G1QXZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/61853:FAR2 ^@ http://purl.uniprot.org/uniprot/G1R0S4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acyl-CoA reductase family.|||Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.|||Peroxisome membrane http://togogenome.org/gene/61853:DISP3 ^@ http://purl.uniprot.org/uniprot/G1REQ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:PELI1 ^@ http://purl.uniprot.org/uniprot/G1RFP9 ^@ Function|||Similarity ^@ Belongs to the pellino family.|||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. http://togogenome.org/gene/61853:SUFU ^@ http://purl.uniprot.org/uniprot/A0A2I3HVV4|||http://purl.uniprot.org/uniprot/G1RYV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUFU family.|||Cytoplasm|||Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).|||Nucleus http://togogenome.org/gene/61853:CALR ^@ http://purl.uniprot.org/uniprot/G1RR67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calreticulin family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/61853:EHF ^@ http://purl.uniprot.org/uniprot/A0A2I3GRJ0|||http://purl.uniprot.org/uniprot/A0A2I3HJ83|||http://purl.uniprot.org/uniprot/G1S8D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/61853:APOM ^@ http://purl.uniprot.org/uniprot/G1R2U6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family. Highly divergent.|||Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.|||Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.|||Secreted http://togogenome.org/gene/61853:FAM135A ^@ http://purl.uniprot.org/uniprot/A0A2I3HC22|||http://purl.uniprot.org/uniprot/A0A2I3HG02 ^@ Similarity ^@ Belongs to the FAM135 family. http://togogenome.org/gene/61853:KIF23 ^@ http://purl.uniprot.org/uniprot/G1RT23|||http://purl.uniprot.org/uniprot/M3ZBV8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/61853:LOC100591010 ^@ http://purl.uniprot.org/uniprot/G1RCJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.|||Secreted http://togogenome.org/gene/61853:TSFM ^@ http://purl.uniprot.org/uniprot/A0A2I3G7P7|||http://purl.uniprot.org/uniprot/A0A2I3GZ06 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Mitochondrion http://togogenome.org/gene/61853:TMEM200A ^@ http://purl.uniprot.org/uniprot/A0A2I3HHI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/61853:SLC9A2 ^@ http://purl.uniprot.org/uniprot/G1RXA5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Interacts with CHP1 and CHP2.|||Membrane http://togogenome.org/gene/61853:HOXD1 ^@ http://purl.uniprot.org/uniprot/G1R257 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/61853:ANKRD13A ^@ http://purl.uniprot.org/uniprot/G1QQB4 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/61853:THAP1 ^@ http://purl.uniprot.org/uniprot/G1RR39 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THAP1 family.|||DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.|||Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.|||nucleoplasm http://togogenome.org/gene/61853:CCR6 ^@ http://purl.uniprot.org/uniprot/A0A2I3GQJ9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:CSGALNACT2 ^@ http://purl.uniprot.org/uniprot/A0A2I3FQ29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/61853:RAD51 ^@ http://purl.uniprot.org/uniprot/A0A2I3H1V5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Nucleus|||Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair. http://togogenome.org/gene/61853:ADSL ^@ http://purl.uniprot.org/uniprot/A0A2I3HJ95 ^@ Function|||Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/61853:ZNF397 ^@ http://purl.uniprot.org/uniprot/A0A2I3HS82 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:RNF182 ^@ http://purl.uniprot.org/uniprot/G1QJI1 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with ATP6V0C.|||Membrane http://togogenome.org/gene/61853:JPT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G1Y4|||http://purl.uniprot.org/uniprot/A0A2I3HLV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:ATP23 ^@ http://purl.uniprot.org/uniprot/G1S5Q6 ^@ Similarity ^@ Belongs to the peptidase M76 family. http://togogenome.org/gene/61853:RAMAC ^@ http://purl.uniprot.org/uniprot/G1RJ78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAM family.|||Nucleus http://togogenome.org/gene/61853:FGF23 ^@ http://purl.uniprot.org/uniprot/G1QS31 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/61853:H1-3 ^@ http://purl.uniprot.org/uniprot/G1S9R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/61853:LOC100591991 ^@ http://purl.uniprot.org/uniprot/G1RDH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/61853:AHCYL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HAP3|||http://purl.uniprot.org/uniprot/A0A2I3HL28 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/61853:SERPINB1 ^@ http://purl.uniprot.org/uniprot/G1RJE1 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/61853:TRAK2 ^@ http://purl.uniprot.org/uniprot/G1R5L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the milton family.|||Early endosome|||Mitochondrion http://togogenome.org/gene/61853:DIPK2A ^@ http://purl.uniprot.org/uniprot/G1QYR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/61853:CASP6 ^@ http://purl.uniprot.org/uniprot/G1S3N0 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/61853:LOC100604844 ^@ http://purl.uniprot.org/uniprot/A0A2I3HVB7 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/61853:HMGN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GLP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/61853:RTEL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GAG0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:RCAN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G8X2|||http://purl.uniprot.org/uniprot/A0A2I3H869 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/61853:STX12 ^@ http://purl.uniprot.org/uniprot/A0A2I3G8I2 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/61853:QTRT2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HE29 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.|||Mitochondrion outer membrane|||Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). http://togogenome.org/gene/61853:PPP5C ^@ http://purl.uniprot.org/uniprot/A0A2I3GLM2|||http://purl.uniprot.org/uniprot/G1QQU2 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. http://togogenome.org/gene/61853:SERPINA11 ^@ http://purl.uniprot.org/uniprot/G1S648 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/61853:CCKBR ^@ http://purl.uniprot.org/uniprot/A0A2I3GRH3|||http://purl.uniprot.org/uniprot/G1S6H1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/61853:TBPL1 ^@ http://purl.uniprot.org/uniprot/G1RX62 ^@ Similarity|||Subunit ^@ Belongs to the TBP family.|||Binds TFIIA and TFIIB. http://togogenome.org/gene/61853:SYPL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GD34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/61853:BAIAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G2R2 ^@ Function|||Subcellular Location Annotation ^@ Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.|||Membrane|||cytoskeleton|||filopodium|||ruffle http://togogenome.org/gene/61853:VAMP1 ^@ http://purl.uniprot.org/uniprot/G1QU66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/61853:BANF2 ^@ http://purl.uniprot.org/uniprot/G1RF11 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:VPS4A ^@ http://purl.uniprot.org/uniprot/A0A2I3HIG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/61853:LOC100592962 ^@ http://purl.uniprot.org/uniprot/G1SBF2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/61853:PCMT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G7N0|||http://purl.uniprot.org/uniprot/A0A2I3H3H4 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/61853:LPL ^@ http://purl.uniprot.org/uniprot/G1QT41 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Cell membrane|||Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.|||Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.|||extracellular matrix http://togogenome.org/gene/61853:KCTD3 ^@ http://purl.uniprot.org/uniprot/G1RW06 ^@ Similarity ^@ Belongs to the KCTD3 family. http://togogenome.org/gene/61853:DOCK1 ^@ http://purl.uniprot.org/uniprot/G1QIA9 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/61853:CSNK1G3 ^@ http://purl.uniprot.org/uniprot/G1RN92 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/61853:LZTS2 ^@ http://purl.uniprot.org/uniprot/G1RXP2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LZTS2 family.|||Cytoplasm|||Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.|||Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.|||centrosome http://togogenome.org/gene/61853:PLCB1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HFW9|||http://purl.uniprot.org/uniprot/G1RVN2 ^@ Cofactor|||Function ^@ Binds 1 Ca(2+) ion per subunit.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/61853:ITK ^@ http://purl.uniprot.org/uniprot/G1QV28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cytoplasm http://togogenome.org/gene/61853:CD9 ^@ http://purl.uniprot.org/uniprot/G1QTK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Cell membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/61853:STK4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GAZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Nucleus http://togogenome.org/gene/61853:PIP ^@ http://purl.uniprot.org/uniprot/G1QRT8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PIP family.|||Monomer. Interacts with AZGP1.|||Secreted http://togogenome.org/gene/61853:MPC2 ^@ http://purl.uniprot.org/uniprot/G1RXY9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:FUT7 ^@ http://purl.uniprot.org/uniprot/G1RC41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/61853:NELL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HW16 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:LOC100603023 ^@ http://purl.uniprot.org/uniprot/A0A2I3HCW9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Binds 2 Zn(2+) ions per subunit.|||Cytoplasm http://togogenome.org/gene/61853:NRF1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HZY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRF1/Ewg family.|||Nucleus http://togogenome.org/gene/61853:GSDMC ^@ http://purl.uniprot.org/uniprot/G1R0M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:UGCG ^@ http://purl.uniprot.org/uniprot/G1S365 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/61853:RASGRP2 ^@ http://purl.uniprot.org/uniprot/G1QZB8 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/61853:CRHBP ^@ http://purl.uniprot.org/uniprot/G1RQ28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CRF-binding protein family.|||Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.|||Secreted http://togogenome.org/gene/61853:LAMP3 ^@ http://purl.uniprot.org/uniprot/G1R282 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/61853:CDH8 ^@ http://purl.uniprot.org/uniprot/G1QUR8 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:AURKA ^@ http://purl.uniprot.org/uniprot/G1R5V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.|||centrosome http://togogenome.org/gene/61853:SNW1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GCS6|||http://purl.uniprot.org/uniprot/G1S4E3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNW family.|||Identified in the spliceosome C complex.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/61853:DNAH10 ^@ http://purl.uniprot.org/uniprot/G1QPB5 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/61853:DLL1 ^@ http://purl.uniprot.org/uniprot/G1QHD7 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/61853:PIAS2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GI93|||http://purl.uniprot.org/uniprot/G1RKU4 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/61853:LOC100603183 ^@ http://purl.uniprot.org/uniprot/G1S9T1 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:SP4 ^@ http://purl.uniprot.org/uniprot/G1S468 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:EXOSC7 ^@ http://purl.uniprot.org/uniprot/G1R280 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:FABP6 ^@ http://purl.uniprot.org/uniprot/G1QWC9 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/61853:TGIF1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HM26|||http://purl.uniprot.org/uniprot/A0A2I3HPT4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:TF ^@ http://purl.uniprot.org/uniprot/A0A0A7RNC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transferrin family.|||Monomer.|||Secreted|||Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. http://togogenome.org/gene/61853:TMEM38B ^@ http://purl.uniprot.org/uniprot/A0A2I3H147|||http://purl.uniprot.org/uniprot/G1S678 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/61853:SUB1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GIC0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional coactivator PC4 family.|||General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).|||Homodimer. Interacts with CSTF2.|||Nucleus http://togogenome.org/gene/61853:HDDC2 ^@ http://purl.uniprot.org/uniprot/G1RUM4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HDDC2 family.|||Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).|||Homodimer. http://togogenome.org/gene/61853:TAF1B ^@ http://purl.uniprot.org/uniprot/G1RTC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRN7/TAF1B family.|||Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.|||nucleolus http://togogenome.org/gene/61853:PACC1 ^@ http://purl.uniprot.org/uniprot/G1QRD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the proton-activated chloride channel family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:CXCL12 ^@ http://purl.uniprot.org/uniprot/A0A2I3GFF0|||http://purl.uniprot.org/uniprot/A0A2I3H6B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/61853:PPP1R9A ^@ http://purl.uniprot.org/uniprot/G1S0K7 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/61853:SEMA3G ^@ http://purl.uniprot.org/uniprot/G1R680 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:ARG1 ^@ http://purl.uniprot.org/uniprot/G1RVZ9 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/61853:LOC100590651 ^@ http://purl.uniprot.org/uniprot/G1SC60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/61853:PIR ^@ http://purl.uniprot.org/uniprot/G1RDY1 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/61853:SYP ^@ http://purl.uniprot.org/uniprot/G1R9A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/61853:CXXC4 ^@ http://purl.uniprot.org/uniprot/G1RS94 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:E2F4 ^@ http://purl.uniprot.org/uniprot/G1QWE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/61853:AFG1L ^@ http://purl.uniprot.org/uniprot/G1RTK2 ^@ Similarity ^@ Belongs to the AFG1 ATPase family. http://togogenome.org/gene/61853:SERPINC1 ^@ http://purl.uniprot.org/uniprot/G1RZC2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the serpin family.|||Forms protease inhibiting heterodimer with TMPRSS7.|||extracellular space http://togogenome.org/gene/61853:LHPP ^@ http://purl.uniprot.org/uniprot/G1QI70 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/61853:TMEM147 ^@ http://purl.uniprot.org/uniprot/G1RKA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM147 family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane http://togogenome.org/gene/61853:ALKBH2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GRU8 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/61853:BCLAF3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GLJ6 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/61853:CNNM4 ^@ http://purl.uniprot.org/uniprot/G1R8E7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ACDP family.|||Cell membrane|||Membrane|||Metal transporter. http://togogenome.org/gene/61853:FABP12 ^@ http://purl.uniprot.org/uniprot/G1QQ39 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/61853:SMPDL3A ^@ http://purl.uniprot.org/uniprot/G1RU96 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) per subunit.|||Secreted http://togogenome.org/gene/61853:PSMB2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HJF8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:TMEM163 ^@ http://purl.uniprot.org/uniprot/G1RAH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM163 family.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/61853:LEPROTL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HLI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/61853:NEUROD6 ^@ http://purl.uniprot.org/uniprot/G1RZ06 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:SIX6 ^@ http://purl.uniprot.org/uniprot/G1RTW5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:STRN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HXE7|||http://purl.uniprot.org/uniprot/M3Z9C1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat striatin family.|||Membrane http://togogenome.org/gene/61853:SNRPD3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HLA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.|||cytosol http://togogenome.org/gene/61853:TSNAX ^@ http://purl.uniprot.org/uniprot/A0A2I3GLF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the translin family.|||Nucleus http://togogenome.org/gene/61853:OST4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GRX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:OASL ^@ http://purl.uniprot.org/uniprot/A0A2I3GG94|||http://purl.uniprot.org/uniprot/A0A2I3GQA6|||http://purl.uniprot.org/uniprot/A0A2I3HP07 ^@ Similarity ^@ Belongs to the 2-5A synthase family. http://togogenome.org/gene/61853:IRF2 ^@ http://purl.uniprot.org/uniprot/G1RJ05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Nucleus http://togogenome.org/gene/61853:RIPK2 ^@ http://purl.uniprot.org/uniprot/G1QN93 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.|||Cytoplasm|||Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.|||Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses. Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments. http://togogenome.org/gene/61853:THG1L ^@ http://purl.uniprot.org/uniprot/G1QVS4 ^@ Cofactor|||Function|||Similarity ^@ Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.|||Belongs to the tRNA(His) guanylyltransferase family.|||Binds 2 magnesium ions per subunit. http://togogenome.org/gene/61853:PRKAA1 ^@ http://purl.uniprot.org/uniprot/G1S3D1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/61853:PPP2R3C ^@ http://purl.uniprot.org/uniprot/G1QU15 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:LOC100587005 ^@ http://purl.uniprot.org/uniprot/G1R9Y0 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/61853:LOC100599698 ^@ http://purl.uniprot.org/uniprot/G1S8U7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:MBOAT7 ^@ http://purl.uniprot.org/uniprot/G1R392 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:USP5 ^@ http://purl.uniprot.org/uniprot/G1QY12 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/61853:PARN ^@ http://purl.uniprot.org/uniprot/G1RH04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Cytoplasm http://togogenome.org/gene/61853:TAF8 ^@ http://purl.uniprot.org/uniprot/A0A2I3HRU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF8 family.|||Nucleus http://togogenome.org/gene/61853:TLR7 ^@ http://purl.uniprot.org/uniprot/G1RD05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/61853:RPRD1B ^@ http://purl.uniprot.org/uniprot/G1R386 ^@ Function|||Similarity|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. http://togogenome.org/gene/61853:TBRG1 ^@ http://purl.uniprot.org/uniprot/G1R778 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:CRAT ^@ http://purl.uniprot.org/uniprot/G1S7C3 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/61853:GPC3 ^@ http://purl.uniprot.org/uniprot/G1QMX0|||http://purl.uniprot.org/uniprot/G1QMX3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/61853:SERPINB5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GI79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family. Ov-serpin subfamily.|||extracellular space http://togogenome.org/gene/61853:GUF1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HIV0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. LepA subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Mitochondrion inner membrane|||Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. http://togogenome.org/gene/61853:CAPZA1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GTL0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/61853:IFNGR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H3K8 ^@ Similarity ^@ Belongs to the type II cytokine receptor family. http://togogenome.org/gene/61853:BBS7 ^@ http://purl.uniprot.org/uniprot/G1RDU8 ^@ Function|||Subunit ^@ Part of BBSome complex.|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. http://togogenome.org/gene/61853:NUBPL ^@ http://purl.uniprot.org/uniprot/G1QSA4 ^@ Similarity ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. http://togogenome.org/gene/61853:LIPH ^@ http://purl.uniprot.org/uniprot/A0A2I3G2Y8|||http://purl.uniprot.org/uniprot/G1R3W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/61853:SLC15A3 ^@ http://purl.uniprot.org/uniprot/G1RTR4 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. http://togogenome.org/gene/61853:ST7 ^@ http://purl.uniprot.org/uniprot/A0A2I3GU99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/61853:PAX5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GKR3|||http://purl.uniprot.org/uniprot/A0A2I3GR99|||http://purl.uniprot.org/uniprot/A0A2I3GTQ1|||http://purl.uniprot.org/uniprot/A0A2I3GZV2|||http://purl.uniprot.org/uniprot/A0A2I3HC84|||http://purl.uniprot.org/uniprot/A0A2I3HGH4|||http://purl.uniprot.org/uniprot/A0A2I3HR16|||http://purl.uniprot.org/uniprot/G1QU51 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:OSBPL10 ^@ http://purl.uniprot.org/uniprot/G1QW23 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/61853:POP5 ^@ http://purl.uniprot.org/uniprot/G1S126 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||nucleolus http://togogenome.org/gene/61853:LOC100595948 ^@ http://purl.uniprot.org/uniprot/G1S2R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 6A family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:TENT5A ^@ http://purl.uniprot.org/uniprot/G1RPH5 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/61853:HPDL ^@ http://purl.uniprot.org/uniprot/G1S9L7 ^@ Cofactor|||Similarity ^@ Belongs to the 4HPPD family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/61853:BHMT2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G1M5 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 zinc ion per subunit.|||Homotetramer.|||Involved in the regulation of homocysteine metabolism. http://togogenome.org/gene/61853:LOC100582948 ^@ http://purl.uniprot.org/uniprot/G1R883 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Membrane http://togogenome.org/gene/61853:UBE2S ^@ http://purl.uniprot.org/uniprot/G1RHT8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/61853:HAMP ^@ http://purl.uniprot.org/uniprot/G1RJV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hepcidin family.|||Secreted http://togogenome.org/gene/61853:CYSLTR1 ^@ http://purl.uniprot.org/uniprot/G1QNF9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:SDR42E1 ^@ http://purl.uniprot.org/uniprot/G1RID6 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/61853:NOX4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HSI0|||http://purl.uniprot.org/uniprot/G1S1V1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:NOX1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H8U0|||http://purl.uniprot.org/uniprot/A0A2I3HAL5|||http://purl.uniprot.org/uniprot/G1R7G9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:PPP1R35 ^@ http://purl.uniprot.org/uniprot/G1RM09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP1R35 family.|||centriole http://togogenome.org/gene/61853:CPS1 ^@ http://purl.uniprot.org/uniprot/G1R6F1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:TMEM88 ^@ http://purl.uniprot.org/uniprot/G1RFA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM88 family.|||Membrane http://togogenome.org/gene/61853:LOC100584815 ^@ http://purl.uniprot.org/uniprot/A0A2I3H952|||http://purl.uniprot.org/uniprot/G1RHA4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/61853:ARL11 ^@ http://purl.uniprot.org/uniprot/A0A2I3FXD0 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/61853:RNF7 ^@ http://purl.uniprot.org/uniprot/A0A2I3GDA7 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/61853:PGAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GZ91|||http://purl.uniprot.org/uniprot/A0A2I3H024 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PGAP2 family.|||Interacts with PGAP2IP.|||Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.|||Membrane http://togogenome.org/gene/61853:SPOCK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HGL0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:SFRP4 ^@ http://purl.uniprot.org/uniprot/A0A2I3H1X7 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:ANXA10 ^@ http://purl.uniprot.org/uniprot/G1R430 ^@ Similarity ^@ Belongs to the annexin family. http://togogenome.org/gene/61853:LNPEP ^@ http://purl.uniprot.org/uniprot/G1RWG3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/61853:IRF6 ^@ http://purl.uniprot.org/uniprot/A0A2I3GRU9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:MMP13 ^@ http://purl.uniprot.org/uniprot/G1R6E4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/61853:GATB ^@ http://purl.uniprot.org/uniprot/G1R1L3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/61853:AKAP4 ^@ http://purl.uniprot.org/uniprot/G1R9M2 ^@ Similarity ^@ Belongs to the AKAP110 family. http://togogenome.org/gene/61853:DDX18 ^@ http://purl.uniprot.org/uniprot/G1RM95 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/61853:TMEM183A ^@ http://purl.uniprot.org/uniprot/G1S907 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM183 family.|||Membrane http://togogenome.org/gene/61853:PDSS2 ^@ http://purl.uniprot.org/uniprot/G1RSV5 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/61853:TMEM192 ^@ http://purl.uniprot.org/uniprot/M3ZB07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM192 family.|||Late endosome|||Lysosome membrane|||Membrane http://togogenome.org/gene/61853:CGA ^@ http://purl.uniprot.org/uniprot/A0A0F7RQQ4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.|||Secreted http://togogenome.org/gene/61853:UPP1 ^@ http://purl.uniprot.org/uniprot/G1QX82 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. http://togogenome.org/gene/61853:MSRA ^@ http://purl.uniprot.org/uniprot/A0A2I3GNB7|||http://purl.uniprot.org/uniprot/A0A2I3H0R5 ^@ Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family. http://togogenome.org/gene/61853:LOC100597116 ^@ http://purl.uniprot.org/uniprot/A0A2I3HEN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.|||nucleolus http://togogenome.org/gene/61853:EIF3L ^@ http://purl.uniprot.org/uniprot/G1RY73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit L family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/61853:SLC35C2 ^@ http://purl.uniprot.org/uniprot/G1R5A8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:ATG12 ^@ http://purl.uniprot.org/uniprot/A0A2I3GKR1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATG12 family.|||Forms a conjugate with ATG5.|||Ubiquitin-like protein involved in autophagic vesicle formation. http://togogenome.org/gene/61853:NPTX1 ^@ http://purl.uniprot.org/uniprot/G1S0T0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:NUDT4 ^@ http://purl.uniprot.org/uniprot/G1R122 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/61853:CREBBP ^@ http://purl.uniprot.org/uniprot/A0A2I3H346|||http://purl.uniprot.org/uniprot/G1RFB2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:PLA2G5 ^@ http://purl.uniprot.org/uniprot/G1R8T9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/61853:RABGGTA ^@ http://purl.uniprot.org/uniprot/A0A2I3GT84 ^@ Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family.|||Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. http://togogenome.org/gene/61853:WFIKKN2 ^@ http://purl.uniprot.org/uniprot/A0A2I3H3L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WFIKKN family.|||Secreted http://togogenome.org/gene/61853:TSPAN7 ^@ http://purl.uniprot.org/uniprot/A0A2I3G9V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/61853:SRD5A1 ^@ http://purl.uniprot.org/uniprot/G1RKY6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Microsome membrane http://togogenome.org/gene/61853:WASHC3 ^@ http://purl.uniprot.org/uniprot/G1R3G5 ^@ Similarity ^@ Belongs to the CCDC53 family. http://togogenome.org/gene/61853:AMDHD1 ^@ http://purl.uniprot.org/uniprot/G1R1L8 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. HutI family. http://togogenome.org/gene/61853:DPRX ^@ http://purl.uniprot.org/uniprot/G1R2R6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:OVOL1 ^@ http://purl.uniprot.org/uniprot/G1R1J8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:LOC100594197 ^@ http://purl.uniprot.org/uniprot/A0A2I3HAC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/61853:FAM133A ^@ http://purl.uniprot.org/uniprot/G1SBJ9 ^@ Similarity ^@ Belongs to the FAM133 family. http://togogenome.org/gene/61853:DCP1A ^@ http://purl.uniprot.org/uniprot/G1R6I4 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/61853:AFF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HAG9 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/61853:GABRG1 ^@ http://purl.uniprot.org/uniprot/G1S687 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/61853:BMP4 ^@ http://purl.uniprot.org/uniprot/G1RQ54 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/61853:FARSA ^@ http://purl.uniprot.org/uniprot/G1RR50 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. http://togogenome.org/gene/61853:MYSM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G9G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. MYSM1 subfamily.|||Nucleus http://togogenome.org/gene/61853:ANKRD34C ^@ http://purl.uniprot.org/uniprot/A0A2I3HQS6 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/61853:EOMES ^@ http://purl.uniprot.org/uniprot/G1QVE0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/61853:LOC100595123 ^@ http://purl.uniprot.org/uniprot/A0A2I3HE11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family.|||Nucleus http://togogenome.org/gene/61853:RASGRP4 ^@ http://purl.uniprot.org/uniprot/A0A2I3G2S9|||http://purl.uniprot.org/uniprot/A0A2I3GQ05|||http://purl.uniprot.org/uniprot/G1S4N8 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/61853:CHIA ^@ http://purl.uniprot.org/uniprot/G1QUR7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. http://togogenome.org/gene/61853:LOC100584639 ^@ http://purl.uniprot.org/uniprot/G1RER6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:GARS1 ^@ http://purl.uniprot.org/uniprot/G1RYU4 ^@ Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Homodimer. http://togogenome.org/gene/61853:FAM174A ^@ http://purl.uniprot.org/uniprot/A0A2I3GFS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/61853:ADPRM ^@ http://purl.uniprot.org/uniprot/G1RH33 ^@ Similarity|||Subunit ^@ Belongs to the ADPRibase-Mn family.|||Monomer. http://togogenome.org/gene/61853:UTS2 ^@ http://purl.uniprot.org/uniprot/G1RBW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urotensin-2 family.|||Secreted http://togogenome.org/gene/61853:CCK ^@ http://purl.uniprot.org/uniprot/G1R1F4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Secreted http://togogenome.org/gene/61853:ZC3H12B ^@ http://purl.uniprot.org/uniprot/G1QHR7 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/61853:RNMT ^@ http://purl.uniprot.org/uniprot/G1RDH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.|||In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.|||Nucleus http://togogenome.org/gene/61853:YARS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HNX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Nucleus http://togogenome.org/gene/61853:HIBCH ^@ http://purl.uniprot.org/uniprot/A0A2I3HX46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.|||Mitochondrion http://togogenome.org/gene/61853:SNAPIN ^@ http://purl.uniprot.org/uniprot/A0A2I3G7A3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAPIN family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.|||synaptic vesicle membrane http://togogenome.org/gene/61853:PDX1 ^@ http://purl.uniprot.org/uniprot/G1QHP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/61853:MPC1L ^@ http://purl.uniprot.org/uniprot/G1SBK2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:LOC100587360 ^@ http://purl.uniprot.org/uniprot/G1RMP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/61853:ETS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HRB8|||http://purl.uniprot.org/uniprot/G1R7C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:IGFL1 ^@ http://purl.uniprot.org/uniprot/G1QPX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IGFL family.|||Secreted http://togogenome.org/gene/61853:C6H5orf22 ^@ http://purl.uniprot.org/uniprot/G1RUU1 ^@ Similarity ^@ Belongs to the UPF0489 family. http://togogenome.org/gene/61853:HOXC8 ^@ http://purl.uniprot.org/uniprot/G1S7G2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:PHACTR3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HNX2|||http://purl.uniprot.org/uniprot/G1REP8 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/61853:MINAR2 ^@ http://purl.uniprot.org/uniprot/G1RPB9 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/61853:HSD17B3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GAD3|||http://purl.uniprot.org/uniprot/A0A2I3H4W6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/61853:ING4 ^@ http://purl.uniprot.org/uniprot/G1QWX0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/61853:LYRM1 ^@ http://purl.uniprot.org/uniprot/G1RNZ4 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/61853:CADM2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GAN6|||http://purl.uniprot.org/uniprot/A0A2I3HSB2 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/61853:SLC9A4 ^@ http://purl.uniprot.org/uniprot/G1RX94 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Interacts with CHP1 and CHP2.|||Membrane http://togogenome.org/gene/61853:CRHR2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GBM1|||http://purl.uniprot.org/uniprot/G1RYV7|||http://purl.uniprot.org/uniprot/G1RYV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Membrane http://togogenome.org/gene/61853:TSPYL4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HAB1 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/61853:PDE7A ^@ http://purl.uniprot.org/uniprot/A0A2I3GCA2|||http://purl.uniprot.org/uniprot/G1QV53 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/61853:CD2 ^@ http://purl.uniprot.org/uniprot/G1QZ89 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:NINJ1 ^@ http://purl.uniprot.org/uniprot/G1S3J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ninjurin family.|||Membrane http://togogenome.org/gene/61853:ARSH ^@ http://purl.uniprot.org/uniprot/A0A2I3GZG1 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/61853:C16H8orf37 ^@ http://purl.uniprot.org/uniprot/A0A2I3HJQ0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in photoreceptor outer segment disk morphogenesis.|||Photoreceptor inner segment http://togogenome.org/gene/61853:MITF ^@ http://purl.uniprot.org/uniprot/A0A2I3GJ87|||http://purl.uniprot.org/uniprot/A0A2I3HVZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/61853:ANXA7 ^@ http://purl.uniprot.org/uniprot/G1S404|||http://purl.uniprot.org/uniprot/M3Z9W5 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/61853:OTUB2 ^@ http://purl.uniprot.org/uniprot/G1S5Z2 ^@ Similarity ^@ Belongs to the peptidase C65 family. http://togogenome.org/gene/61853:FAS ^@ http://purl.uniprot.org/uniprot/A0A2I3GTP2|||http://purl.uniprot.org/uniprot/G1RNU4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane raft http://togogenome.org/gene/61853:CDK15 ^@ http://purl.uniprot.org/uniprot/A0A2I3GNU6|||http://purl.uniprot.org/uniprot/A0A2I3HSF2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:PHOX2B ^@ http://purl.uniprot.org/uniprot/A0A2I3GB05 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:ZZZ3 ^@ http://purl.uniprot.org/uniprot/A0A2I3H6P2|||http://purl.uniprot.org/uniprot/G1REY9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:EXTL2 ^@ http://purl.uniprot.org/uniprot/G1RML5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:MRPS11 ^@ http://purl.uniprot.org/uniprot/A0A2I3G2D3|||http://purl.uniprot.org/uniprot/A0A2I3HJZ0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/61853:LDB2 ^@ http://purl.uniprot.org/uniprot/A0A2I3H4Z2 ^@ Similarity ^@ Belongs to the LDB family. http://togogenome.org/gene/61853:LOC100587002 ^@ http://purl.uniprot.org/uniprot/G1RB34 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NADPH--cytochrome P450 reductase family.|||Binds 1 FAD per monomer.|||Binds 1 FMN per monomer.|||Endoplasmic reticulum membrane|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. http://togogenome.org/gene/61853:SLC41A3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GBP7|||http://purl.uniprot.org/uniprot/G1QJK4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/61853:ARHGEF12 ^@ http://purl.uniprot.org/uniprot/A0A2I3HFE2|||http://purl.uniprot.org/uniprot/A0A2I3HG46|||http://purl.uniprot.org/uniprot/G1R756 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Membrane http://togogenome.org/gene/61853:STMN2 ^@ http://purl.uniprot.org/uniprot/G1QP10 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/61853:RIPPLY1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G522|||http://purl.uniprot.org/uniprot/G1RU63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ripply family.|||Nucleus http://togogenome.org/gene/61853:IZUMO3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GBT4 ^@ Similarity ^@ Belongs to the Izumo family. http://togogenome.org/gene/61853:KLHL15 ^@ http://purl.uniprot.org/uniprot/G1RG82 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:APOD ^@ http://purl.uniprot.org/uniprot/G1RAG0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Homodimer.|||Secreted http://togogenome.org/gene/61853:LAMTOR5 ^@ http://purl.uniprot.org/uniprot/G1QTV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR5 family.|||Lysosome http://togogenome.org/gene/61853:MINDY1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H6Q3 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM63 subfamily.|||Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. http://togogenome.org/gene/61853:PTH2R ^@ http://purl.uniprot.org/uniprot/A0A2I3GJZ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:PHF19 ^@ http://purl.uniprot.org/uniprot/A0A2I3HDV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/61853:AASS ^@ http://purl.uniprot.org/uniprot/G1RMY3 ^@ Similarity ^@ In the C-terminal section; belongs to the saccharopine dehydrogenase family.|||In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/61853:ITPRIPL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G6E2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Membrane http://togogenome.org/gene/61853:NSF ^@ http://purl.uniprot.org/uniprot/A0A2I3G312 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. http://togogenome.org/gene/61853:E2F6 ^@ http://purl.uniprot.org/uniprot/A0A2I3GWE2|||http://purl.uniprot.org/uniprot/G1RVD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/61853:ERLIN1 ^@ http://purl.uniprot.org/uniprot/G1RXE0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the band 7/mec-2 family.|||Endoplasmic reticulum membrane|||Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.|||Membrane http://togogenome.org/gene/61853:ETFA ^@ http://purl.uniprot.org/uniprot/G1R9T7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/61853:ZKSCAN3 ^@ http://purl.uniprot.org/uniprot/G1QX65 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:ING1 ^@ http://purl.uniprot.org/uniprot/A0A2I3I0C1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/61853:APOC3 ^@ http://purl.uniprot.org/uniprot/G1R6X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C3 family.|||Secreted http://togogenome.org/gene/61853:CCNA2 ^@ http://purl.uniprot.org/uniprot/G1RDS0 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily. http://togogenome.org/gene/61853:CRH ^@ http://purl.uniprot.org/uniprot/A0A2I3GJV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/61853:TENM2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GI61 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family. Teneurin subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:ARID5B ^@ http://purl.uniprot.org/uniprot/A0A2I3GU13|||http://purl.uniprot.org/uniprot/A0A2I3H250 ^@ Similarity ^@ Belongs to the ARID5B family. http://togogenome.org/gene/61853:NPNT ^@ http://purl.uniprot.org/uniprot/A0A2I3GFX8|||http://purl.uniprot.org/uniprot/G1RRN3|||http://purl.uniprot.org/uniprot/M3Z9E0 ^@ Caution|||Similarity ^@ Belongs to the nephronectin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:POLR3H ^@ http://purl.uniprot.org/uniprot/G1S030 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/61853:RNF114 ^@ http://purl.uniprot.org/uniprot/G1R5P2 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.|||Nucleus http://togogenome.org/gene/61853:GTF2A1L ^@ http://purl.uniprot.org/uniprot/A0A2I3G894|||http://purl.uniprot.org/uniprot/A0A2I3HC58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 1 family.|||Nucleus http://togogenome.org/gene/61853:PLAC8L1 ^@ http://purl.uniprot.org/uniprot/G1RFF3 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/61853:BLOC1S3 ^@ http://purl.uniprot.org/uniprot/G1S9W1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BLOC1S3 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).|||Cytoplasm http://togogenome.org/gene/61853:DCST2 ^@ http://purl.uniprot.org/uniprot/G1RLK0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:NR0B1 ^@ http://purl.uniprot.org/uniprot/G1RGF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus|||Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency. http://togogenome.org/gene/61853:LOC100587536 ^@ http://purl.uniprot.org/uniprot/A0A2I3G1L3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:NKAIN2 ^@ http://purl.uniprot.org/uniprot/A0A2I3H4J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:NOS2 ^@ http://purl.uniprot.org/uniprot/G1QMC7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NOS family.|||Binds 1 FAD.|||Binds 1 FMN.|||Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. http://togogenome.org/gene/61853:EREG ^@ http://purl.uniprot.org/uniprot/G1R8Z6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:YAF2 ^@ http://purl.uniprot.org/uniprot/G1S8G1|||http://purl.uniprot.org/uniprot/G1S8G2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:CXCL11 ^@ http://purl.uniprot.org/uniprot/G1R9B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/61853:RASSF5 ^@ http://purl.uniprot.org/uniprot/G1QIK8 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/61853:TCTEX1D4 ^@ http://purl.uniprot.org/uniprot/G1RVD1 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/61853:NT5E ^@ http://purl.uniprot.org/uniprot/G1RQP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-nucleotidase family.|||Membrane http://togogenome.org/gene/61853:PTPN13 ^@ http://purl.uniprot.org/uniprot/A0A2I3G8U4|||http://purl.uniprot.org/uniprot/A0A2I3GNY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/61853:SOX3 ^@ http://purl.uniprot.org/uniprot/G1SB06 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:LOC100597206 ^@ http://purl.uniprot.org/uniprot/G1R7V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/61853:SF3A1 ^@ http://purl.uniprot.org/uniprot/G1QU96 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:CCT6A ^@ http://purl.uniprot.org/uniprot/A0A2I3H249 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/61853:PAIP2B ^@ http://purl.uniprot.org/uniprot/A0A2I3HXF9 ^@ Similarity ^@ Belongs to the PAIP2 family. http://togogenome.org/gene/61853:BMPR1B ^@ http://purl.uniprot.org/uniprot/G1RVC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/61853:STMN4 ^@ http://purl.uniprot.org/uniprot/A0A2I3FQR6|||http://purl.uniprot.org/uniprot/A0A2I3G8B5|||http://purl.uniprot.org/uniprot/A0A2I3HSE2 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/61853:CUEDC2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GD53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUEDC2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:BSX ^@ http://purl.uniprot.org/uniprot/G1R766 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:PSMA3 ^@ http://purl.uniprot.org/uniprot/G1RRR8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/61853:SPCS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HI38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:TOM1L1 ^@ http://purl.uniprot.org/uniprot/G1R947 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/61853:GLRX ^@ http://purl.uniprot.org/uniprot/G1RVE4 ^@ Function|||Similarity ^@ Belongs to the glutaredoxin family.|||Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. http://togogenome.org/gene/61853:ARPP19 ^@ http://purl.uniprot.org/uniprot/G1R444 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. http://togogenome.org/gene/61853:STRADA ^@ http://purl.uniprot.org/uniprot/A0A2I3GCF7 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. http://togogenome.org/gene/61853:CASTOR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GI52 ^@ Similarity ^@ Belongs to the GATS family. http://togogenome.org/gene/61853:PRR15 ^@ http://purl.uniprot.org/uniprot/A0A2I3G8A8 ^@ Similarity ^@ Belongs to the PRR15 family. http://togogenome.org/gene/61853:ATP6V0A2 ^@ http://purl.uniprot.org/uniprot/G1QNC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/61853:C15H11orf58 ^@ http://purl.uniprot.org/uniprot/A0A2I3HQ93 ^@ Similarity ^@ Belongs to the SMAP family. http://togogenome.org/gene/61853:VPS26C ^@ http://purl.uniprot.org/uniprot/A0A2I3H7C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS26 family.|||Endosome http://togogenome.org/gene/61853:EMSY ^@ http://purl.uniprot.org/uniprot/A0A2I3GUW3|||http://purl.uniprot.org/uniprot/A0A2I3HLV2|||http://purl.uniprot.org/uniprot/A0A2I3I018 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:NXPH1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HT56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/61853:ND4L ^@ http://purl.uniprot.org/uniprot/E7EAD2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4L family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:BEND6 ^@ http://purl.uniprot.org/uniprot/G1QRH8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:LOC100591193 ^@ http://purl.uniprot.org/uniprot/G1S9R7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:PTGFR ^@ http://purl.uniprot.org/uniprot/G1RFF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:ADCY5 ^@ http://purl.uniprot.org/uniprot/A0A2I3HXJ2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/61853:UFM1 ^@ http://purl.uniprot.org/uniprot/G1QQ89 ^@ Function|||Similarity ^@ Belongs to the UFM1 family.|||Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. http://togogenome.org/gene/61853:NDUFA3 ^@ http://purl.uniprot.org/uniprot/A0A2I3G418 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA3 subunit family.|||Complex I is composed of 45 different subunits.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:SZRD1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBV6|||http://purl.uniprot.org/uniprot/G1R8I4 ^@ Similarity ^@ Belongs to the SZRD1 family. http://togogenome.org/gene/61853:SLC7A6OS ^@ http://purl.uniprot.org/uniprot/G1QZF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IWR1/SLC7A6OS family.|||Cytoplasm|||Directs RNA polymerase II nuclear import.|||Nucleus http://togogenome.org/gene/61853:GABRA3 ^@ http://purl.uniprot.org/uniprot/G1RU38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/61853:FAM229B ^@ http://purl.uniprot.org/uniprot/G1RRA5 ^@ Similarity ^@ Belongs to the FAM229 family. http://togogenome.org/gene/61853:TMEM255A ^@ http://purl.uniprot.org/uniprot/A0A2I3HCV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM255 family.|||Membrane http://togogenome.org/gene/61853:AOX1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GID8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/61853:TPD52 ^@ http://purl.uniprot.org/uniprot/A0A2I3GQN3|||http://purl.uniprot.org/uniprot/A0A2I3H321|||http://purl.uniprot.org/uniprot/A0A2I3HEE0|||http://purl.uniprot.org/uniprot/G1QPH6 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/61853:WRNIP1 ^@ http://purl.uniprot.org/uniprot/G1RJ84 ^@ Similarity ^@ Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. http://togogenome.org/gene/61853:DDX54 ^@ http://purl.uniprot.org/uniprot/G1QH06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.|||nucleolus http://togogenome.org/gene/61853:TIMM21 ^@ http://purl.uniprot.org/uniprot/A0A2I3GTR1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM21 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane|||Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. http://togogenome.org/gene/61853:TMEM11 ^@ http://purl.uniprot.org/uniprot/G1QGQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM11 family.|||Membrane|||Plays a role in mitochondrial morphogenesis. http://togogenome.org/gene/61853:SF1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GTB5|||http://purl.uniprot.org/uniprot/A0A2I3HLQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BBP/SF1 family.|||Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.|||Nucleus http://togogenome.org/gene/61853:TOR1AIP1 ^@ http://purl.uniprot.org/uniprot/G1S125 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TOR1AIP family.|||Membrane http://togogenome.org/gene/61853:PCNX4 ^@ http://purl.uniprot.org/uniprot/G1RTK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/61853:SPR ^@ http://purl.uniprot.org/uniprot/A0A2I3GCA6 ^@ Similarity ^@ Belongs to the sepiapterin reductase family. http://togogenome.org/gene/61853:IMMP1L ^@ http://purl.uniprot.org/uniprot/G1S888 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family.|||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:LOC100595480 ^@ http://purl.uniprot.org/uniprot/A0A2I3H4A1 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/61853:RPL35 ^@ http://purl.uniprot.org/uniprot/A0A2I3GH94 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/61853:GIMAP8 ^@ http://purl.uniprot.org/uniprot/G1QUJ8 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/61853:BCL9 ^@ http://purl.uniprot.org/uniprot/A0A2I3HDY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BCL9 family.|||Nucleus http://togogenome.org/gene/61853:CHMP2B ^@ http://purl.uniprot.org/uniprot/A0A2I3HLR0 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/61853:TIMM8B ^@ http://purl.uniprot.org/uniprot/A0A2I3GMG1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/61853:ATP5MC2 ^@ http://purl.uniprot.org/uniprot/G1S7H2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/61853:PRKAR1A ^@ http://purl.uniprot.org/uniprot/A0A2I3HG51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:LOC100605478 ^@ http://purl.uniprot.org/uniprot/A0A2I3H5F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:CSNK1A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HMA6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:BLOC1S6 ^@ http://purl.uniprot.org/uniprot/A0A2I3GWD7 ^@ Function|||Similarity ^@ Belongs to the BLOC1S6 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. http://togogenome.org/gene/61853:SIRT4 ^@ http://purl.uniprot.org/uniprot/G1S0B4 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant.|||Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion.|||Belongs to the sirtuin family. Class II subfamily.|||Binds 1 zinc ion per subunit.|||Interacts with GLUD1, IDE and SLC25A5. Interacts with DLAT and PDHX.|||Mitochondrion matrix http://togogenome.org/gene/61853:CRIPT ^@ http://purl.uniprot.org/uniprot/G1S4X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRIPT family.|||Cytoplasm http://togogenome.org/gene/61853:KDSR ^@ http://purl.uniprot.org/uniprot/G1RBM9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/61853:LOC100596916 ^@ http://purl.uniprot.org/uniprot/G1SCC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:OTC ^@ http://purl.uniprot.org/uniprot/G1QKJ1 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily.|||Homotrimer. http://togogenome.org/gene/61853:CCNB1 ^@ http://purl.uniprot.org/uniprot/G1QVD5 ^@ Function|||Similarity ^@ Belongs to the cyclin family.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition. http://togogenome.org/gene/61853:PIGL ^@ http://purl.uniprot.org/uniprot/A0A2I3G1X8 ^@ Function|||Similarity ^@ Belongs to the PIGL family.|||Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol. http://togogenome.org/gene/61853:GPR50 ^@ http://purl.uniprot.org/uniprot/G1RTJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:RFC4 ^@ http://purl.uniprot.org/uniprot/G1R4J2 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/61853:GJA8 ^@ http://purl.uniprot.org/uniprot/G1QHA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/61853:GJB6 ^@ http://purl.uniprot.org/uniprot/A0A2I3H161 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/61853:CLEC10A ^@ http://purl.uniprot.org/uniprot/G1RDT8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:TMEM199 ^@ http://purl.uniprot.org/uniprot/G1QNM2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:STC1 ^@ http://purl.uniprot.org/uniprot/G1S1I1 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/61853:WNT5B ^@ http://purl.uniprot.org/uniprot/G1QQI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/61853:OPN4 ^@ http://purl.uniprot.org/uniprot/G1QPI6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:ENPP3 ^@ http://purl.uniprot.org/uniprot/G1RWL2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/61853:ALG11 ^@ http://purl.uniprot.org/uniprot/A0A2I3GFA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.|||Endoplasmic reticulum membrane|||Required for N-linked oligosaccharide assembly. http://togogenome.org/gene/61853:PAQR6 ^@ http://purl.uniprot.org/uniprot/A0A2I3GAH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/61853:CNPY2 ^@ http://purl.uniprot.org/uniprot/G1S6W6 ^@ Similarity ^@ Belongs to the canopy family. http://togogenome.org/gene/61853:CCDC90B ^@ http://purl.uniprot.org/uniprot/G1S3F0 ^@ Similarity ^@ Belongs to the CCDC90 family. http://togogenome.org/gene/61853:CCSER2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HLR5|||http://purl.uniprot.org/uniprot/G1RJD3|||http://purl.uniprot.org/uniprot/G1RJD5 ^@ Similarity ^@ Belongs to the CCSER family. http://togogenome.org/gene/61853:UBE2B ^@ http://purl.uniprot.org/uniprot/G1R9J2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/61853:A3GALT2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HMK1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 6 family.|||Binds 1 Mn(2+) ion per subunit.|||Membrane http://togogenome.org/gene/61853:EPCAM ^@ http://purl.uniprot.org/uniprot/G1RAJ6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPCAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lateral cell membrane|||May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.|||Membrane|||tight junction http://togogenome.org/gene/61853:TM4SF5 ^@ http://purl.uniprot.org/uniprot/G1S6H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/61853:GABARAP ^@ http://purl.uniprot.org/uniprot/A0A2I3GQ66 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/61853:MRPS31 ^@ http://purl.uniprot.org/uniprot/G1QKE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS31 family.|||Mitochondrion http://togogenome.org/gene/61853:PTGES ^@ http://purl.uniprot.org/uniprot/G1S7D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/61853:CA9 ^@ http://purl.uniprot.org/uniprot/A0A2I3GE59 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/61853:SLC30A10 ^@ http://purl.uniprot.org/uniprot/G1RV68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/61853:DYNC1H1 ^@ http://purl.uniprot.org/uniprot/G1S1B6 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/61853:MRPL46 ^@ http://purl.uniprot.org/uniprot/G1RKZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL46 family.|||Mitochondrion http://togogenome.org/gene/61853:SSBP1 ^@ http://purl.uniprot.org/uniprot/G1QPH4 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/61853:YIPF5 ^@ http://purl.uniprot.org/uniprot/G1RFD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/61853:PTDSS1 ^@ http://purl.uniprot.org/uniprot/G1QTX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphatidyl serine synthase family.|||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:PANX3 ^@ http://purl.uniprot.org/uniprot/G1R777 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/61853:LOC100589061 ^@ http://purl.uniprot.org/uniprot/G1R3I0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/61853:ADPRHL2 ^@ http://purl.uniprot.org/uniprot/G1RKG8 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/61853:OLFML3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HTP6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:TMEM254 ^@ http://purl.uniprot.org/uniprot/A0A2I3HLS3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:PATL2 ^@ http://purl.uniprot.org/uniprot/G1R112 ^@ Similarity ^@ Belongs to the PAT1 family. http://togogenome.org/gene/61853:DEUP1 ^@ http://purl.uniprot.org/uniprot/G1R617 ^@ Similarity ^@ Belongs to the CEP63 family. http://togogenome.org/gene/61853:LOC100606797 ^@ http://purl.uniprot.org/uniprot/A0A2I3H409 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/61853:DAD1 ^@ http://purl.uniprot.org/uniprot/G1RX68 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAD/OST2 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/61853:ADH4 ^@ http://purl.uniprot.org/uniprot/G1RUJ0 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/61853:ZKSCAN7 ^@ http://purl.uniprot.org/uniprot/A0A2I3HLF5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:SMAGP ^@ http://purl.uniprot.org/uniprot/G1S7U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMAGP family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/61853:NANOG ^@ http://purl.uniprot.org/uniprot/G1RYL3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:AP5M1 ^@ http://purl.uniprot.org/uniprot/G1RRC4 ^@ Subcellular Location Annotation|||Subunit ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. http://togogenome.org/gene/61853:GC ^@ http://purl.uniprot.org/uniprot/G1R874 ^@ Function|||Subcellular Location Annotation ^@ Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.|||Secreted http://togogenome.org/gene/61853:CPPED1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GBP0 ^@ Function|||Similarity ^@ Belongs to the metallophosphoesterase superfamily. CPPED1 family.|||Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes. http://togogenome.org/gene/61853:TCAF1 ^@ http://purl.uniprot.org/uniprot/G1QT46 ^@ Similarity ^@ Belongs to the TCAF family. http://togogenome.org/gene/61853:SLC35A5 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:GSG1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GV41|||http://purl.uniprot.org/uniprot/A0A2I3HCH4|||http://purl.uniprot.org/uniprot/G1QUA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSG1 family.|||Membrane http://togogenome.org/gene/61853:DDX49 ^@ http://purl.uniprot.org/uniprot/G1R2N8 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/61853:GDF2 ^@ http://purl.uniprot.org/uniprot/G1RZS9 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/61853:PNRC1 ^@ http://purl.uniprot.org/uniprot/G1RRK5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:NME6 ^@ http://purl.uniprot.org/uniprot/A0A2I3HWM5 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/61853:PGAM1 ^@ http://purl.uniprot.org/uniprot/G1RUA8 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/61853:KRT85 ^@ http://purl.uniprot.org/uniprot/A0A2I3GSY4|||http://purl.uniprot.org/uniprot/G1S7R8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/61853:POLR2F ^@ http://purl.uniprot.org/uniprot/G1RY98 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.|||Nucleus http://togogenome.org/gene/61853:LYRM4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GUA2|||http://purl.uniprot.org/uniprot/A0A2I3H651 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/61853:TUBB ^@ http://purl.uniprot.org/uniprot/G1R063 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/61853:GLRB ^@ http://purl.uniprot.org/uniprot/A0A2I3HSM1|||http://purl.uniprot.org/uniprot/G1R388 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:TRPM8 ^@ http://purl.uniprot.org/uniprot/A0A2I3HAN8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:CCDC167 ^@ http://purl.uniprot.org/uniprot/G1RKC2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:MCOLN2 ^@ http://purl.uniprot.org/uniprot/G1RG31 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/61853:SMU1 ^@ http://purl.uniprot.org/uniprot/G1QZJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SMU1 family.|||Nucleus speckle http://togogenome.org/gene/61853:TLR1 ^@ http://purl.uniprot.org/uniprot/G1S5C6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane|||Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. http://togogenome.org/gene/61853:OLAH ^@ http://purl.uniprot.org/uniprot/G1RP21 ^@ Similarity ^@ Belongs to the thioesterase family. http://togogenome.org/gene/61853:ZNF622 ^@ http://purl.uniprot.org/uniprot/G1RMH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the REI1 family.|||Cytoplasm http://togogenome.org/gene/61853:AP4S1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HNQ4 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/61853:ELP3 ^@ http://purl.uniprot.org/uniprot/G1S3P5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. http://togogenome.org/gene/61853:PIP4P2 ^@ http://purl.uniprot.org/uniprot/G1QPQ0 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/61853:PAXBP1 ^@ http://purl.uniprot.org/uniprot/G1QUH6 ^@ Similarity ^@ Belongs to the GCF family. http://togogenome.org/gene/61853:SLC11A1 ^@ http://purl.uniprot.org/uniprot/G1RBA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAMP family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/61853:ASAH1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HGS8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acid ceramidase family.|||Heterodimer.|||Lysosome http://togogenome.org/gene/61853:RPS6KA1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G2C2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/61853:MPPED2 ^@ http://purl.uniprot.org/uniprot/G1S874 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/61853:HOXD10 ^@ http://purl.uniprot.org/uniprot/G1R249 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/61853:COPS5 ^@ http://purl.uniprot.org/uniprot/G1RJ82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN5 subfamily.|||synaptic vesicle http://togogenome.org/gene/61853:VIL1 ^@ http://purl.uniprot.org/uniprot/G1RBF3 ^@ Similarity ^@ Belongs to the villin/gelsolin family. http://togogenome.org/gene/61853:RELL2 ^@ http://purl.uniprot.org/uniprot/G1RES6 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/61853:NSUN2 ^@ http://purl.uniprot.org/uniprot/G1RKW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||extracellular exosome http://togogenome.org/gene/61853:C15H11orf54 ^@ http://purl.uniprot.org/uniprot/A0A2I3GUC7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.|||Monomer.|||Nucleus http://togogenome.org/gene/61853:TRMT11 ^@ http://purl.uniprot.org/uniprot/G1RV59 ^@ Function|||Subunit ^@ Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.|||Interacts with TRMT112. http://togogenome.org/gene/61853:MAML3 ^@ http://purl.uniprot.org/uniprot/G1QYX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mastermind family.|||Nucleus speckle http://togogenome.org/gene/61853:PMM2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GIK8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/61853:LOC100592640 ^@ http://purl.uniprot.org/uniprot/A0A2I3H8R1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:SPDEF ^@ http://purl.uniprot.org/uniprot/A0A2I3H7Y4|||http://purl.uniprot.org/uniprot/G1RAF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/61853:S100B ^@ http://purl.uniprot.org/uniprot/G1QSV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/61853:PTS ^@ http://purl.uniprot.org/uniprot/A0A2I3GIM5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the PTPS family.|||Binds 1 zinc ion per subunit.|||Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. http://togogenome.org/gene/61853:PPEF1 ^@ http://purl.uniprot.org/uniprot/A0A2I3FYA1 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/61853:VAMP8 ^@ http://purl.uniprot.org/uniprot/G1QN71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/61853:TMED1 ^@ http://purl.uniprot.org/uniprot/G1RP56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/61853:CLRN2 ^@ http://purl.uniprot.org/uniprot/G1S3P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/61853:AKAP5 ^@ http://purl.uniprot.org/uniprot/G1SBT7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:ADAMTS5 ^@ http://purl.uniprot.org/uniprot/G1QR75 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/61853:HHIPL2 ^@ http://purl.uniprot.org/uniprot/G1RTU4 ^@ Similarity ^@ Belongs to the HHIP family. http://togogenome.org/gene/61853:TGFB3 ^@ http://purl.uniprot.org/uniprot/G1S3M8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.|||extracellular matrix http://togogenome.org/gene/61853:RAD54L2 ^@ http://purl.uniprot.org/uniprot/G1R5V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/61853:AKR1B10 ^@ http://purl.uniprot.org/uniprot/G1RRL9 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/61853:TGM3 ^@ http://purl.uniprot.org/uniprot/G1RDJ9 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/61853:POLRMT ^@ http://purl.uniprot.org/uniprot/G1QJ40 ^@ Function|||Similarity ^@ Belongs to the phage and mitochondrial RNA polymerase family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/61853:PPP2CB ^@ http://purl.uniprot.org/uniprot/G1RMV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/61853:AFF4 ^@ http://purl.uniprot.org/uniprot/G1RQY5 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/61853:LOC100582700 ^@ http://purl.uniprot.org/uniprot/G1SAM3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:AJAP1 ^@ http://purl.uniprot.org/uniprot/G1R9N6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:TBX3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HGG6|||http://purl.uniprot.org/uniprot/G1QH79 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/61853:BAZ1B ^@ http://purl.uniprot.org/uniprot/G1RCG7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:DDX50 ^@ http://purl.uniprot.org/uniprot/G1RLT0 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily. http://togogenome.org/gene/61853:CES5A ^@ http://purl.uniprot.org/uniprot/A0A2I3I0C8|||http://purl.uniprot.org/uniprot/G1QMJ9 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/61853:LHCGR ^@ http://purl.uniprot.org/uniprot/G1RBV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||Membrane|||Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. http://togogenome.org/gene/61853:MRE11 ^@ http://purl.uniprot.org/uniprot/A0A2I3GFZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MRE11/RAD32 family.|||Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.|||Nucleus http://togogenome.org/gene/61853:COQ10A ^@ http://purl.uniprot.org/uniprot/G1S6X5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/61853:ACR ^@ http://purl.uniprot.org/uniprot/G1QKK8 ^@ Function|||Subunit ^@ Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.|||Heavy chain (catalytic) and a light chain linked by two disulfide bonds. Forms a heterodimer with SERPINA5. http://togogenome.org/gene/61853:CHST2 ^@ http://purl.uniprot.org/uniprot/G1QYK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/61853:LOC100596044 ^@ http://purl.uniprot.org/uniprot/G1S9J5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:DPYS ^@ http://purl.uniprot.org/uniprot/G1QUV8 ^@ PTM|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Carbamylation allows a single lysine to coordinate two divalent metal cations. http://togogenome.org/gene/61853:ADAMTS15 ^@ http://purl.uniprot.org/uniprot/G1R7F0 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/61853:POLR1E ^@ http://purl.uniprot.org/uniprot/A0A2I3G1H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.|||nucleolus http://togogenome.org/gene/61853:SLC25A26 ^@ http://purl.uniprot.org/uniprot/G1R7J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/61853:HBEGF ^@ http://purl.uniprot.org/uniprot/G1RDD1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:ZNF263 ^@ http://purl.uniprot.org/uniprot/G1REP5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:MYADML2 ^@ http://purl.uniprot.org/uniprot/A0A2I3FUB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/61853:PPP1R3C ^@ http://purl.uniprot.org/uniprot/G1RPF2 ^@ Domain|||Function|||Subunit ^@ Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.|||Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.|||The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase. http://togogenome.org/gene/61853:NDUFB5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GGZ9|||http://purl.uniprot.org/uniprot/A0A2I3HSE6|||http://purl.uniprot.org/uniprot/A0A2I3HYD1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:KRTCAP2 ^@ http://purl.uniprot.org/uniprot/G1RMG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KRTCAP2 family.|||Membrane http://togogenome.org/gene/61853:CASP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GQA0 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/61853:SH3GL3 ^@ http://purl.uniprot.org/uniprot/G1RIU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Membrane http://togogenome.org/gene/61853:IYD ^@ http://purl.uniprot.org/uniprot/A0A2I3GFV1|||http://purl.uniprot.org/uniprot/G1RZH7|||http://purl.uniprot.org/uniprot/G1RZH8 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/61853:GINS1 ^@ http://purl.uniprot.org/uniprot/G1S0I5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS1/PSF1 family.|||Chromosome|||Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.|||Nucleus|||Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/61853:EMC2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HKT0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC2 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. http://togogenome.org/gene/61853:FICD ^@ http://purl.uniprot.org/uniprot/G1R4W1 ^@ Similarity ^@ Belongs to the fic family. http://togogenome.org/gene/61853:POMGNT2 ^@ http://purl.uniprot.org/uniprot/G1R1Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 61 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:SEC24A ^@ http://purl.uniprot.org/uniprot/A0A2I3I0D0|||http://purl.uniprot.org/uniprot/G1R9P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/61853:SH3BGRL ^@ http://purl.uniprot.org/uniprot/G1QQ20 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/61853:RBM48 ^@ http://purl.uniprot.org/uniprot/A0A2I3HB57 ^@ Function|||Similarity|||Subunit ^@ As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.|||Belongs to the RBM48 family.|||Component of the minor spliceosome. Within this complex, interacts with ARMC7 and PRPF8/PRP8. http://togogenome.org/gene/61853:ADGRD1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HYW2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:CCDC25 ^@ http://purl.uniprot.org/uniprot/G1S3F4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC25 family.|||Cell membrane|||Endomembrane system|||Interacts (via cytoplasmic region) with ILK. http://togogenome.org/gene/61853:EAF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3H636|||http://purl.uniprot.org/uniprot/G1QH83 ^@ Similarity ^@ Belongs to the EAF family. http://togogenome.org/gene/61853:POPDC2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GU86|||http://purl.uniprot.org/uniprot/G1QYP7 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/61853:DARS2 ^@ http://purl.uniprot.org/uniprot/G1RZB2 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. http://togogenome.org/gene/61853:ZDHHC17 ^@ http://purl.uniprot.org/uniprot/G1QY94 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/61853:HARBI1 ^@ http://purl.uniprot.org/uniprot/G1RUU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HARBI1 family.|||Cytoplasm|||Nucleus|||Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity. http://togogenome.org/gene/61853:TSPAN33 ^@ http://purl.uniprot.org/uniprot/G1RPU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/61853:CCDC85A ^@ http://purl.uniprot.org/uniprot/G1RE16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC85 family.|||adherens junction http://togogenome.org/gene/61853:TRAPPC6B ^@ http://purl.uniprot.org/uniprot/A0A2I3GQT9|||http://purl.uniprot.org/uniprot/G1QVE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/61853:C9 ^@ http://purl.uniprot.org/uniprot/G1S351 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/61853:PPP4R2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HP16 ^@ Similarity ^@ Belongs to the PPP4R2 family. http://togogenome.org/gene/61853:SULT6B1 ^@ http://purl.uniprot.org/uniprot/G1S2D4 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/61853:LOC100595959 ^@ http://purl.uniprot.org/uniprot/G1S9R7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:LANCL1 ^@ http://purl.uniprot.org/uniprot/G1R6D9 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/61853:MCHR2 ^@ http://purl.uniprot.org/uniprot/G1RUA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:S100Z ^@ http://purl.uniprot.org/uniprot/G1RQ12 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/61853:SIVA1 ^@ http://purl.uniprot.org/uniprot/G1S2S9 ^@ Function|||PTM|||Subcellular Location Annotation ^@ Cytoplasm|||Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.|||Nucleus|||Phosphorylated by ABL2/ARG in response to oxidative stress. http://togogenome.org/gene/61853:ADGRL4 ^@ http://purl.uniprot.org/uniprot/G1RFG5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:GDE1 ^@ http://purl.uniprot.org/uniprot/G1RPU6 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/61853:PAGE3 ^@ http://purl.uniprot.org/uniprot/G1S2T8 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/61853:CEP63 ^@ http://purl.uniprot.org/uniprot/A0A2I3H4V1 ^@ Similarity ^@ Belongs to the CEP63 family. http://togogenome.org/gene/61853:XCR1 ^@ http://purl.uniprot.org/uniprot/G1R2I4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:SARS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GRL2|||http://purl.uniprot.org/uniprot/G1QQH6 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. http://togogenome.org/gene/61853:MGME1 ^@ http://purl.uniprot.org/uniprot/G1RF53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGME1 family.|||Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair.|||Mitochondrion http://togogenome.org/gene/61853:SPHKAP ^@ http://purl.uniprot.org/uniprot/A0A2I3HG14|||http://purl.uniprot.org/uniprot/G1RT80 ^@ Similarity ^@ Belongs to the AKAP110 family. http://togogenome.org/gene/61853:STAC ^@ http://purl.uniprot.org/uniprot/G1QY77 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/61853:INTS9 ^@ http://purl.uniprot.org/uniprot/G1S418 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.|||Nucleus http://togogenome.org/gene/61853:HYAL1 ^@ http://purl.uniprot.org/uniprot/G1R5P3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/61853:TFE3 ^@ http://purl.uniprot.org/uniprot/G1R928 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/61853:SYF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HZ55 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYF2 family.|||Involved in pre-mRNA splicing.|||May be part of a spliceosome complex.|||Nucleus http://togogenome.org/gene/61853:XIAP ^@ http://purl.uniprot.org/uniprot/G1RYI2 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/61853:ITGA6 ^@ http://purl.uniprot.org/uniprot/G1R0U3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/61853:S100A9 ^@ http://purl.uniprot.org/uniprot/G1RHE3 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/61853:TAF10 ^@ http://purl.uniprot.org/uniprot/G1S6Q1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF10 family.|||Nucleus|||The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. http://togogenome.org/gene/61853:CTNND2 ^@ http://purl.uniprot.org/uniprot/G1RM42 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/61853:IMPAD1 ^@ http://purl.uniprot.org/uniprot/G1QKW2 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/61853:CLCN4 ^@ http://purl.uniprot.org/uniprot/G1RCA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/61853:RAN ^@ http://purl.uniprot.org/uniprot/A0A2I3H4R5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ran family.|||GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.|||Nucleus http://togogenome.org/gene/61853:RARB ^@ http://purl.uniprot.org/uniprot/G1QU20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/61853:DXO ^@ http://purl.uniprot.org/uniprot/G1R3V9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DXO/Dom3Z family.|||Binds 2 magnesium ions.|||Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.|||Nucleus http://togogenome.org/gene/61853:SLC1A3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HK04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/61853:TAFA2 ^@ http://purl.uniprot.org/uniprot/G1S5L6 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/61853:PTER ^@ http://purl.uniprot.org/uniprot/G1RPD6 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.|||Binds 2 divalent metal cations per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:DDA1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GAU3 ^@ Similarity ^@ Belongs to the DDA1 family. http://togogenome.org/gene/61853:CWC25 ^@ http://purl.uniprot.org/uniprot/G1QIJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CWC25 family.|||Nucleus http://togogenome.org/gene/61853:SLA ^@ http://purl.uniprot.org/uniprot/G1R1H5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:LBP ^@ http://purl.uniprot.org/uniprot/G1R3G3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.|||Secreted|||When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14. http://togogenome.org/gene/61853:GCLC ^@ http://purl.uniprot.org/uniprot/A0A2I3H9B7|||http://purl.uniprot.org/uniprot/G1QTF2 ^@ Similarity ^@ Belongs to the glutamate--cysteine ligase type 3 family. http://togogenome.org/gene/61853:PLLP ^@ http://purl.uniprot.org/uniprot/A0A2I3HND8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:LAMC1 ^@ http://purl.uniprot.org/uniprot/G1S8P7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||basement membrane http://togogenome.org/gene/61853:GTF2A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GQX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 1 family.|||Nucleus http://togogenome.org/gene/61853:AMPD2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GIT1|||http://purl.uniprot.org/uniprot/G1QS94 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Homotetramer. http://togogenome.org/gene/61853:LRRC8A ^@ http://purl.uniprot.org/uniprot/G1S7B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:IBSP ^@ http://purl.uniprot.org/uniprot/G1REL7 ^@ Function|||Subcellular Location Annotation ^@ Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.|||Secreted http://togogenome.org/gene/61853:ARL3 ^@ http://purl.uniprot.org/uniprot/G1RYW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/61853:GPNMB ^@ http://purl.uniprot.org/uniprot/G1RXI4 ^@ Similarity ^@ Belongs to the PMEL/NMB family. http://togogenome.org/gene/61853:ETFRF1 ^@ http://purl.uniprot.org/uniprot/G1QZI7 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/61853:MPHOSPH10 ^@ http://purl.uniprot.org/uniprot/G1RH15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MPP10 family.|||Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.|||nucleolus http://togogenome.org/gene/61853:CD34 ^@ http://purl.uniprot.org/uniprot/G1QL96 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:TBCD ^@ http://purl.uniprot.org/uniprot/G1RIG4 ^@ Similarity ^@ Belongs to the TBCD family. http://togogenome.org/gene/61853:PACSIN2 ^@ http://purl.uniprot.org/uniprot/G1S1U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PACSIN family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome membrane|||Membrane|||Recycling endosome membrane|||caveola|||cytoskeleton|||ruffle membrane http://togogenome.org/gene/61853:PLSCR5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GQF8|||http://purl.uniprot.org/uniprot/G1QPH9 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/61853:FLOT2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GZQ1|||http://purl.uniprot.org/uniprot/G1QSA3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Cell membrane|||Endosome|||Heterooligomeric complex.|||Membrane|||caveola http://togogenome.org/gene/61853:CR2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G1L1|||http://purl.uniprot.org/uniprot/A0A2I3HBK1|||http://purl.uniprot.org/uniprot/G1QKA0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:ASB4 ^@ http://purl.uniprot.org/uniprot/G1S134 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/61853:GATA3 ^@ http://purl.uniprot.org/uniprot/G1RMR6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:HADHB ^@ http://purl.uniprot.org/uniprot/G1QNG1 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/61853:LRP3 ^@ http://purl.uniprot.org/uniprot/G1R808 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:PLA2G15 ^@ http://purl.uniprot.org/uniprot/G1QZA5 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/61853:EIF4ENIF1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H6U7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:LOC100586929 ^@ http://purl.uniprot.org/uniprot/G1QTU3 ^@ Similarity ^@ Belongs to the SPAN-X family. http://togogenome.org/gene/61853:CORO6 ^@ http://purl.uniprot.org/uniprot/G1QTL6 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/61853:G6PC3 ^@ http://purl.uniprot.org/uniprot/G1R0M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/61853:ARSK ^@ http://purl.uniprot.org/uniprot/G1RV90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Lysosome http://togogenome.org/gene/61853:MED29 ^@ http://purl.uniprot.org/uniprot/G1RWB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 29 family.|||Nucleus http://togogenome.org/gene/61853:RNASEH2A ^@ http://purl.uniprot.org/uniprot/G1RQQ5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RNase HII family. Eukaryotic subfamily.|||Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/61853:AGMAT ^@ http://purl.uniprot.org/uniprot/G1R7U7 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/61853:NFYB ^@ http://purl.uniprot.org/uniprot/A0A2I3GML6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NFYB/HAP3 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.|||Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP. http://togogenome.org/gene/61853:CENPK ^@ http://purl.uniprot.org/uniprot/A0A2I3GUC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-K/MCM22 family.|||Nucleus|||centromere http://togogenome.org/gene/61853:ARF4 ^@ http://purl.uniprot.org/uniprot/A0A2I3H955 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/61853:SVOPL ^@ http://purl.uniprot.org/uniprot/G1RU70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/61853:PAX4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GNE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/61853:SLC35A2 ^@ http://purl.uniprot.org/uniprot/G1R8X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:CPLX3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HHZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/61853:SLIT1 ^@ http://purl.uniprot.org/uniprot/G1RTQ5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:IMMT ^@ http://purl.uniprot.org/uniprot/G1QQV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic60 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:SLU7 ^@ http://purl.uniprot.org/uniprot/A0A2I3I0I7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SLU7 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/61853:GNG12 ^@ http://purl.uniprot.org/uniprot/A0A2I3H7I5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/61853:MRPL30 ^@ http://purl.uniprot.org/uniprot/A0A2I3HG29 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/61853:BGLAP ^@ http://purl.uniprot.org/uniprot/A0A2I3GHP2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the osteocalcin/matrix Gla protein family.|||Binds strongly to apatite and calcium.|||Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.|||Secreted http://togogenome.org/gene/61853:LOC100582782 ^@ http://purl.uniprot.org/uniprot/A0A2I3GEH6 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/61853:PRKCG ^@ http://purl.uniprot.org/uniprot/G1R2Y3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.|||Cytoplasm|||Membrane http://togogenome.org/gene/61853:GTF2A2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HGK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. http://togogenome.org/gene/61853:SLC2A13 ^@ http://purl.uniprot.org/uniprot/G1S8H8 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/61853:VGLL3 ^@ http://purl.uniprot.org/uniprot/G1RM70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs.|||Nucleus http://togogenome.org/gene/61853:CUTC ^@ http://purl.uniprot.org/uniprot/A0A2I3HPK0 ^@ Similarity ^@ Belongs to the CutC family. http://togogenome.org/gene/61853:LOC100579760 ^@ http://purl.uniprot.org/uniprot/G1S976 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:ACSL5 ^@ http://purl.uniprot.org/uniprot/G1S106 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion outer membrane http://togogenome.org/gene/61853:GNAT2 ^@ http://purl.uniprot.org/uniprot/G1QRS9 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/61853:PCSK9 ^@ http://purl.uniprot.org/uniprot/G1RWX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S8 family.|||Cell surface|||Cytoplasm|||Endoplasmic reticulum|||Endosome|||Golgi apparatus|||Lysosome http://togogenome.org/gene/61853:TNMD ^@ http://purl.uniprot.org/uniprot/G1R7F9 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/61853:SPAST ^@ http://purl.uniprot.org/uniprot/A0A2I3GDR1|||http://purl.uniprot.org/uniprot/G1S0D4 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches.|||Allosteric enzyme with a cooperative mechanism; at least two neighbor subunits influence each other strongly in spastin hexamers. Microtubule binding promotes cooperative interactions among spastin subunits.|||Belongs to the AAA ATPase family. Spastin subfamily.|||Cytoplasm|||Endoplasmic reticulum|||Homohexamer. Mostly monomeric, but assembles into hexameric structure for short periods of time. Oligomerization seems to be a prerequisite for catalytic activity. Binding to ATP in a cleft between two adjacent subunits stabilizes the homohexameric form. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. The hexamer adopts a ring conformation through which microtubules pass prior to being severed. Does not interact strongly with tubulin heterodimers. Interacts (via MIT domain) with CHMP1B; the interaction is direct. Interacts with SSNA1. Interacts with ATL1. Interacts with RTN1. Interacts with ZFYVE27. Interacts with REEP1. Interacts (via MIT domain) with IST1.|||Membrane|||Midbody|||Nucleus|||axon|||centrosome|||cytoskeleton|||perinuclear region|||spindle http://togogenome.org/gene/61853:INPP5J ^@ http://purl.uniprot.org/uniprot/G1QW39 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family. http://togogenome.org/gene/61853:CAB39L ^@ http://purl.uniprot.org/uniprot/G1QTT4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/61853:NUF2 ^@ http://purl.uniprot.org/uniprot/G1RX55 ^@ Similarity ^@ Belongs to the NUF2 family. http://togogenome.org/gene/61853:TNP1 ^@ http://purl.uniprot.org/uniprot/G1R6Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear transition protein 1 family.|||Chromosome|||Nucleus http://togogenome.org/gene/61853:CACNG2 ^@ http://purl.uniprot.org/uniprot/G1RX54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. http://togogenome.org/gene/61853:CDH24 ^@ http://purl.uniprot.org/uniprot/G1RY18 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:SPSB4 ^@ http://purl.uniprot.org/uniprot/G1QX22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Cytoplasm http://togogenome.org/gene/61853:ALG8 ^@ http://purl.uniprot.org/uniprot/A0A2I3HB56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:THUMPD2 ^@ http://purl.uniprot.org/uniprot/G1S3L4 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/61853:LOC100588656 ^@ http://purl.uniprot.org/uniprot/A0A2I3G9Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:AUP1 ^@ http://purl.uniprot.org/uniprot/G1QJH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AUP1 family.|||Membrane http://togogenome.org/gene/61853:SUGCT ^@ http://purl.uniprot.org/uniprot/G1QS87 ^@ Similarity ^@ Belongs to the CoA-transferase III family. http://togogenome.org/gene/61853:STEAP2 ^@ http://purl.uniprot.org/uniprot/G1RYQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/61853:ZSCAN23 ^@ http://purl.uniprot.org/uniprot/A0A2I3HH08 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:TRPV2 ^@ http://purl.uniprot.org/uniprot/G1RXC4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:YTHDF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GR11 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/61853:NDUFA10 ^@ http://purl.uniprot.org/uniprot/A0A2I3HF56 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA10 subunit family.|||Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.|||Mitochondrion matrix http://togogenome.org/gene/61853:UBR2 ^@ http://purl.uniprot.org/uniprot/G1QXU9 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/61853:GPR12 ^@ http://purl.uniprot.org/uniprot/A0A2I3H7W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:GLB1 ^@ http://purl.uniprot.org/uniprot/G1QX00 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/61853:PLD2 ^@ http://purl.uniprot.org/uniprot/G1S6J5 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/61853:NPC1L1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H0I0|||http://purl.uniprot.org/uniprot/G1QUH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/61853:DNTTIP2 ^@ http://purl.uniprot.org/uniprot/G1RIY0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/61853:TBX18 ^@ http://purl.uniprot.org/uniprot/G1RQM8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/61853:DCLRE1C ^@ http://purl.uniprot.org/uniprot/E5FGH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/61853:DPP4 ^@ http://purl.uniprot.org/uniprot/G1QQ71 ^@ Subcellular Location Annotation ^@ Cell membrane|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/61853:IFRD1 ^@ http://purl.uniprot.org/uniprot/G1RKL6 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/61853:REXO2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GTF8 ^@ Similarity ^@ Belongs to the oligoribonuclease family. http://togogenome.org/gene/61853:STX6 ^@ http://purl.uniprot.org/uniprot/G1S1P9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Golgi apparatus membrane http://togogenome.org/gene/61853:CLCN1 ^@ http://purl.uniprot.org/uniprot/G1QSM6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:PPDPF ^@ http://purl.uniprot.org/uniprot/G1RGC5 ^@ Similarity ^@ Belongs to the PPDPF family. http://togogenome.org/gene/61853:SLC5A7 ^@ http://purl.uniprot.org/uniprot/G1RIZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:AMOT ^@ http://purl.uniprot.org/uniprot/G1RX10 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/61853:SMR3B ^@ http://purl.uniprot.org/uniprot/G1R810 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/61853:GAR1 ^@ http://purl.uniprot.org/uniprot/G1S3M5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GAR1 family.|||Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).|||Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.|||nucleolus http://togogenome.org/gene/61853:ENDOU ^@ http://purl.uniprot.org/uniprot/G1S8B9 ^@ Similarity|||Subunit ^@ Belongs to the ENDOU family.|||Monomer. http://togogenome.org/gene/61853:SFXN1 ^@ http://purl.uniprot.org/uniprot/G1QIB8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/61853:HCAR1 ^@ http://purl.uniprot.org/uniprot/A0A4Y1JWR7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:DSG3 ^@ http://purl.uniprot.org/uniprot/G1R3V6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||desmosome http://togogenome.org/gene/61853:C4H18orf25 ^@ http://purl.uniprot.org/uniprot/G1RKC4|||http://purl.uniprot.org/uniprot/M3Z9J7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:ATP1B2 ^@ http://purl.uniprot.org/uniprot/G1RF36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/61853:ZSCAN18 ^@ http://purl.uniprot.org/uniprot/A0A2I3HAM6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:CLCN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HG94|||http://purl.uniprot.org/uniprot/G1R4F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.|||Cell membrane|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/61853:VAMP7 ^@ http://purl.uniprot.org/uniprot/G1RWQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/61853:ORC2 ^@ http://purl.uniprot.org/uniprot/G1R5I7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC2 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Component of the origin recognition complex (ORC).|||Nucleus http://togogenome.org/gene/61853:CHAF1B ^@ http://purl.uniprot.org/uniprot/G1QWT6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:STX10 ^@ http://purl.uniprot.org/uniprot/A0A2I3H0J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Golgi apparatus membrane http://togogenome.org/gene/61853:FGF16 ^@ http://purl.uniprot.org/uniprot/G1QK87 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/61853:SGK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GN77|||http://purl.uniprot.org/uniprot/A0A2I3H0Z4|||http://purl.uniprot.org/uniprot/G1RXA9 ^@ Similarity ^@ Belongs to the protein kinase superfamily.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/61853:IZUMO1 ^@ http://purl.uniprot.org/uniprot/G1QXF7 ^@ Similarity ^@ Belongs to the Izumo family. http://togogenome.org/gene/61853:HTRA1 ^@ http://purl.uniprot.org/uniprot/G1S581 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/61853:MOG ^@ http://purl.uniprot.org/uniprot/A0A2I3H556 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Homodimer.|||Membrane|||Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion. http://togogenome.org/gene/61853:SKA2 ^@ http://purl.uniprot.org/uniprot/G1RAZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SKA2 family.|||spindle http://togogenome.org/gene/61853:MPP5 ^@ http://purl.uniprot.org/uniprot/G1QIC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane|||Endomembrane system|||adherens junction|||tight junction http://togogenome.org/gene/61853:PPP3CA ^@ http://purl.uniprot.org/uniprot/A0A2I3GKB6 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/61853:STK38L ^@ http://purl.uniprot.org/uniprot/M3ZBR7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:ASPA ^@ http://purl.uniprot.org/uniprot/G1S5Z4 ^@ Cofactor|||Similarity ^@ Belongs to the AspA/AstE family. Aspartoacylase subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/61853:EBP ^@ http://purl.uniprot.org/uniprot/G1R8J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:PRUNE1 ^@ http://purl.uniprot.org/uniprot/G1RGC0 ^@ Similarity ^@ Belongs to the PPase class C family. Prune subfamily. http://togogenome.org/gene/61853:PSMB3 ^@ http://purl.uniprot.org/uniprot/G1QIF0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:SUSD4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GLI7|||http://purl.uniprot.org/uniprot/G1QI11 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:C1AH9orf64 ^@ http://purl.uniprot.org/uniprot/G1QTD8 ^@ Function|||Similarity ^@ Belongs to the QNG1 protein family.|||Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly. http://togogenome.org/gene/61853:ECRG4 ^@ http://purl.uniprot.org/uniprot/G1RIF2 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the augurin family.|||Cytoplasm|||Membrane|||Secreted http://togogenome.org/gene/61853:BCL7B ^@ http://purl.uniprot.org/uniprot/A0A2I3HTC7 ^@ Similarity ^@ Belongs to the BCL7 family. http://togogenome.org/gene/61853:CASP3 ^@ http://purl.uniprot.org/uniprot/G1RJ33 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/61853:PTPRG ^@ http://purl.uniprot.org/uniprot/A0A2I3H9Q3|||http://purl.uniprot.org/uniprot/G1RLQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.|||Membrane http://togogenome.org/gene/61853:RPL36 ^@ http://purl.uniprot.org/uniprot/G1RTM2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/61853:ADAMTS20 ^@ http://purl.uniprot.org/uniprot/A0A2I3GNM7 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/61853:GOLPH3 ^@ http://purl.uniprot.org/uniprot/A0A2I3G6G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Golgi stack membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/61853:SCTR ^@ http://purl.uniprot.org/uniprot/G1RH59 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:GLUD2 ^@ http://purl.uniprot.org/uniprot/G1S9P7 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/61853:RPL23 ^@ http://purl.uniprot.org/uniprot/A0A2I3G6A1 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/61853:ALG3 ^@ http://purl.uniprot.org/uniprot/G1R321 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.|||Belongs to the glycosyltransferase 58 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:ZCCHC8 ^@ http://purl.uniprot.org/uniprot/G1QMJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZCCHC8 family.|||nucleoplasm http://togogenome.org/gene/61853:PEX3 ^@ http://purl.uniprot.org/uniprot/G1RYK7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with PEX19.|||Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.|||Peroxisome membrane http://togogenome.org/gene/61853:SLC30A1 ^@ http://purl.uniprot.org/uniprot/G1QQ97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/61853:ACTC1 ^@ http://purl.uniprot.org/uniprot/G1RK14 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/61853:SLC25A53 ^@ http://purl.uniprot.org/uniprot/G1S9N8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/61853:ATP13A5 ^@ http://purl.uniprot.org/uniprot/G1R4Z4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:SAMM50 ^@ http://purl.uniprot.org/uniprot/G1S0W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAM50/omp85 family.|||Mitochondrion outer membrane http://togogenome.org/gene/61853:KCNJ8 ^@ http://purl.uniprot.org/uniprot/G1QYC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/61853:ATP6V1G3 ^@ http://purl.uniprot.org/uniprot/G1S8V8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/61853:DBR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HQ27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lariat debranching enzyme family.|||Nucleus http://togogenome.org/gene/61853:RIDA ^@ http://purl.uniprot.org/uniprot/A0A2I3GN25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RutC family.|||Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.|||Peroxisome http://togogenome.org/gene/61853:GPR68 ^@ http://purl.uniprot.org/uniprot/G1SC85 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:TUBD1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GZR1|||http://purl.uniprot.org/uniprot/G1QIU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Nucleus|||centriole|||cilium http://togogenome.org/gene/61853:HS3ST2 ^@ http://purl.uniprot.org/uniprot/A0A2I3FS76 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/61853:SCAMP3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HVB4|||http://purl.uniprot.org/uniprot/G1RN29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/61853:CDC73 ^@ http://purl.uniprot.org/uniprot/G1S8U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC73 family.|||Nucleus http://togogenome.org/gene/61853:ND3 ^@ http://purl.uniprot.org/uniprot/E7EAE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 3 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.|||Mitochondrion membrane http://togogenome.org/gene/61853:TMEM167B ^@ http://purl.uniprot.org/uniprot/G1RRV1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:OPN1SW ^@ http://purl.uniprot.org/uniprot/G1RPB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane|||Photoreceptor inner segment|||perinuclear region|||photoreceptor outer segment http://togogenome.org/gene/61853:ANTKMT ^@ http://purl.uniprot.org/uniprot/A0A2I3HV38|||http://purl.uniprot.org/uniprot/G1R9Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANT/ATPSC lysine N-methyltransferase family.|||Mitochondrion membrane http://togogenome.org/gene/61853:HINT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G9Q4 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/61853:ASF1B ^@ http://purl.uniprot.org/uniprot/A0A2I3H660 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/61853:VDAC3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GKR5|||http://purl.uniprot.org/uniprot/G1RR08 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/61853:EFHB ^@ http://purl.uniprot.org/uniprot/G1QT81 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/61853:GTPBP10 ^@ http://purl.uniprot.org/uniprot/G1RYU0 ^@ Similarity ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. http://togogenome.org/gene/61853:TRMU ^@ http://purl.uniprot.org/uniprot/A0A2I3GEY8|||http://purl.uniprot.org/uniprot/G1S0U6 ^@ Function|||Similarity ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. http://togogenome.org/gene/61853:NEK7 ^@ http://purl.uniprot.org/uniprot/G1S8V7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:FAM83F ^@ http://purl.uniprot.org/uniprot/G1RZA1 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/61853:PPIA ^@ http://purl.uniprot.org/uniprot/A0A248QIH0|||http://purl.uniprot.org/uniprot/Q0ZQK7 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization (By similarity). PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition (By similarity). Acetylation at Lys-125 favors the interaction with TARDBP (By similarity).|||Belongs to the cyclophilin-type PPIase family.|||Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.|||Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.|||Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity).|||Cytoplasm|||Interacts with protein phosphatase PPP3CA/calcineurin A (By similarity). Interacts with isoform 2 of BSG/CD147 (By similarity). Interacts with FOXO1; the interaction promotes FOXO1 dephosphorylation, nuclear accumulation and transcriptional activity (By similarity). Interacts with integrin ITGA2B:ITGB3; the interaction is ROS and peptidyl-prolyl cis-trans isomerase (PPIase) activity-dependent and is increased in the presence of thrombin (By similarity). Interacts with MAP3K5 (By similarity). Interacts with TARDBP; the interaction is dependent on the RNA-binding activity of TARDBP and the PPIase activity of PPIA/CYPA and the acetylation of PPIA/CYPA at Lys-125 favors the interaction (By similarity). Interacts with HNRNPA1, HNRNPA2B1, HNRNPC, RBMX, HNRNPK and HNRNPM (By similarity).|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.|||Secreted http://togogenome.org/gene/61853:OAS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H3E5|||http://purl.uniprot.org/uniprot/G1QGV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-5A synthase family.|||Cytoplasm http://togogenome.org/gene/61853:RAB3IL1 ^@ http://purl.uniprot.org/uniprot/G1QSN9 ^@ Similarity ^@ Belongs to the SEC2 family. http://togogenome.org/gene/61853:WNT8A ^@ http://purl.uniprot.org/uniprot/A0A2I3GZJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/61853:RAD50 ^@ http://purl.uniprot.org/uniprot/G1RQJ8 ^@ Similarity ^@ Belongs to the SMC family. RAD50 subfamily. http://togogenome.org/gene/61853:LOC100587403 ^@ http://purl.uniprot.org/uniprot/A0A2I3HIA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/61853:GRHL2 ^@ http://purl.uniprot.org/uniprot/G1QSX7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:SPRR2G ^@ http://purl.uniprot.org/uniprot/A0A2I3HIG0 ^@ Similarity ^@ Belongs to the cornifin (SPRR) family. http://togogenome.org/gene/61853:GNPDA2 ^@ http://purl.uniprot.org/uniprot/G1S682 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/61853:CAPZA3 ^@ http://purl.uniprot.org/uniprot/G1SA78 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/61853:CRISP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HWX3|||http://purl.uniprot.org/uniprot/G1QV91 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:POPDC3 ^@ http://purl.uniprot.org/uniprot/G1RVC5 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/61853:ITGB6 ^@ http://purl.uniprot.org/uniprot/A0A2I3G233|||http://purl.uniprot.org/uniprot/A0A2I3GWK8|||http://purl.uniprot.org/uniprot/G1QM06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:TNFSF15 ^@ http://purl.uniprot.org/uniprot/G1S4L9 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/61853:DDAH2 ^@ http://purl.uniprot.org/uniprot/G1R336 ^@ Function|||Similarity ^@ Belongs to the DDAH family.|||Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. http://togogenome.org/gene/61853:PORCN ^@ http://purl.uniprot.org/uniprot/A0A2I3GC52|||http://purl.uniprot.org/uniprot/G1R8I9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:TOR2A ^@ http://purl.uniprot.org/uniprot/G1S6S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ClpA/ClpB family. Torsin subfamily.|||Endoplasmic reticulum lumen http://togogenome.org/gene/61853:SELENOO ^@ http://purl.uniprot.org/uniprot/A0A2I3HUH2 ^@ Similarity ^@ Belongs to the SELO family. http://togogenome.org/gene/61853:PEX16 ^@ http://purl.uniprot.org/uniprot/A0A2I3HUQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-16 family.|||Peroxisome membrane http://togogenome.org/gene/61853:MGST2 ^@ http://purl.uniprot.org/uniprot/A0A2I3H5N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:GNGT1 ^@ http://purl.uniprot.org/uniprot/G1RZQ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/61853:ACTG1 ^@ http://purl.uniprot.org/uniprot/G1RTV2 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/61853:ADGRG5 ^@ http://purl.uniprot.org/uniprot/G1QS61 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:GPR119 ^@ http://purl.uniprot.org/uniprot/G1S9Q0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:TMEM97 ^@ http://purl.uniprot.org/uniprot/A0A2I3H6K7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TMEM97/sigma-2 receptor family.|||Endoplasmic reticulum membrane|||Interacts with NPC1.|||Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.|||Membrane|||Nucleus membrane|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/61853:LOC100584971 ^@ http://purl.uniprot.org/uniprot/G1S982 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:IL26 ^@ http://purl.uniprot.org/uniprot/G1QTG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/61853:DMRTC2 ^@ http://purl.uniprot.org/uniprot/G1RT55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/61853:EVA1A ^@ http://purl.uniprot.org/uniprot/G1QK85 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/61853:PIH1D3 ^@ http://purl.uniprot.org/uniprot/G1RUE5 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/61853:HSPA9 ^@ http://purl.uniprot.org/uniprot/G1RCT8 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/61853:TSPAN9 ^@ http://purl.uniprot.org/uniprot/A0A2I3FVE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/61853:SENP8 ^@ http://purl.uniprot.org/uniprot/A0A2I3G8U3 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/61853:GAD2 ^@ http://purl.uniprot.org/uniprot/G1S4I7 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/61853:SPTLC2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HUF9 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/61853:NECTIN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HKQ3 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/61853:ZBED9 ^@ http://purl.uniprot.org/uniprot/G1QX86 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:SH2D1A ^@ http://purl.uniprot.org/uniprot/G1RYQ3 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. http://togogenome.org/gene/61853:DYNC1LI1 ^@ http://purl.uniprot.org/uniprot/G1QWD3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.|||Belongs to the dynein light intermediate chain family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).|||cytoskeleton http://togogenome.org/gene/61853:COQ5 ^@ http://purl.uniprot.org/uniprot/G1S0N6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).|||Mitochondrion inner membrane http://togogenome.org/gene/61853:CDK6 ^@ http://purl.uniprot.org/uniprot/G1RZD7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:CCDC172 ^@ http://purl.uniprot.org/uniprot/G1S2Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC172 family.|||Cytoplasm http://togogenome.org/gene/61853:LOC100601632 ^@ http://purl.uniprot.org/uniprot/G1SC64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:SS18 ^@ http://purl.uniprot.org/uniprot/A0A2I3G283 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/61853:SLC19A2 ^@ http://purl.uniprot.org/uniprot/G1RY86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Cell membrane|||High-affinity transporter for the intake of thiamine. http://togogenome.org/gene/61853:NLGN4X ^@ http://purl.uniprot.org/uniprot/A0A2I3FPU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:TP53RK ^@ http://purl.uniprot.org/uniprot/A0A2I3HVJ4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. BUD32 family. http://togogenome.org/gene/61853:TRDMT1 ^@ http://purl.uniprot.org/uniprot/G1RPT3 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/61853:CHRNA9 ^@ http://purl.uniprot.org/uniprot/G1S5P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/61853:EIF3K ^@ http://purl.uniprot.org/uniprot/A0A2I3HRY5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit K family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:LYN ^@ http://purl.uniprot.org/uniprot/G1QKJ0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/61853:ADAT2 ^@ http://purl.uniprot.org/uniprot/G1RYJ4 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.|||Probably participates in deamination of adenosine-34 to inosine in many tRNAs. http://togogenome.org/gene/61853:LYZ ^@ http://purl.uniprot.org/uniprot/G1QUK3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/61853:HUS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HMZ4 ^@ Similarity ^@ Belongs to the HUS1 family. http://togogenome.org/gene/61853:HPX ^@ http://purl.uniprot.org/uniprot/G1S6J2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hemopexin family.|||Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.|||Secreted http://togogenome.org/gene/61853:LOC100591694 ^@ http://purl.uniprot.org/uniprot/G1SCC6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:CHRNG ^@ http://purl.uniprot.org/uniprot/A0A2I3GQF9|||http://purl.uniprot.org/uniprot/G1RVX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/61853:LOC100606037 ^@ http://purl.uniprot.org/uniprot/G1QL29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/61853:PGAM2 ^@ http://purl.uniprot.org/uniprot/G1QTL8 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/61853:CXCL6 ^@ http://purl.uniprot.org/uniprot/G1R8X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/61853:B3GALNT2 ^@ http://purl.uniprot.org/uniprot/G1QRM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:TSPAN13 ^@ http://purl.uniprot.org/uniprot/G1S3F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/61853:FAM234A ^@ http://purl.uniprot.org/uniprot/G1R988 ^@ Similarity ^@ Belongs to the FAM234 family. http://togogenome.org/gene/61853:FAM210A ^@ http://purl.uniprot.org/uniprot/G1RDC7 ^@ Similarity ^@ Belongs to the FAM210 family. http://togogenome.org/gene/61853:CA8 ^@ http://purl.uniprot.org/uniprot/G1QN06 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/61853:CCL26 ^@ http://purl.uniprot.org/uniprot/G1RB74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/61853:C17H7orf25 ^@ http://purl.uniprot.org/uniprot/G1QSB6 ^@ Similarity ^@ Belongs to the UPF0415 family. http://togogenome.org/gene/61853:ACTRT3 ^@ http://purl.uniprot.org/uniprot/G1QYU7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/61853:GNS ^@ http://purl.uniprot.org/uniprot/A0A2I3HGX1 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Lysosome|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/61853:OGG1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GAC1 ^@ Function|||Similarity ^@ Belongs to the type-1 OGG1 family.|||DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. http://togogenome.org/gene/61853:C4H11orf68 ^@ http://purl.uniprot.org/uniprot/A0A2I3HVD2 ^@ Similarity ^@ Belongs to the UPF0696 family. http://togogenome.org/gene/61853:ZDHHC6 ^@ http://purl.uniprot.org/uniprot/G1S129 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/61853:MS4A2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HX60 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/61853:NMS ^@ http://purl.uniprot.org/uniprot/G1RW65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NmU family.|||Secreted http://togogenome.org/gene/61853:XRCC4 ^@ http://purl.uniprot.org/uniprot/E5FGK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XRCC4 subfamily.|||Nucleus http://togogenome.org/gene/61853:PRAMEF8 ^@ http://purl.uniprot.org/uniprot/G1RFK9 ^@ Similarity ^@ Belongs to the PRAME family. http://togogenome.org/gene/61853:LOC100597637 ^@ http://purl.uniprot.org/uniprot/G1SAW5 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:CFL2 ^@ http://purl.uniprot.org/uniprot/G1QT84 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/61853:VSX2 ^@ http://purl.uniprot.org/uniprot/G1S2B2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:ZFP36L1 ^@ http://purl.uniprot.org/uniprot/G1QJY0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Nucleus|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/61853:ST8SIA3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HDR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/61853:TCP1 ^@ http://purl.uniprot.org/uniprot/G1RKC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||centrosome http://togogenome.org/gene/61853:LOC100607281 ^@ http://purl.uniprot.org/uniprot/A0A2I3HIR5 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Cell projection|||Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Perikaryon|||Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm. http://togogenome.org/gene/61853:GFRA3 ^@ http://purl.uniprot.org/uniprot/G1RC71 ^@ Similarity ^@ Belongs to the GDNFR family. http://togogenome.org/gene/61853:KCTD13 ^@ http://purl.uniprot.org/uniprot/M3Z9T1 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/61853:STXBP5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GPE1|||http://purl.uniprot.org/uniprot/A0A2I3GWC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/61853:C7 ^@ http://purl.uniprot.org/uniprot/G1S3G7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:WDR91 ^@ http://purl.uniprot.org/uniprot/G1RSC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR91 family.|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/61853:LOC100589965 ^@ http://purl.uniprot.org/uniprot/G1RD74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/61853:STEAP4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HA22|||http://purl.uniprot.org/uniprot/G1RYN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/61853:DKK2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HC56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/61853:NOP10 ^@ http://purl.uniprot.org/uniprot/G1RJU0 ^@ Similarity ^@ Belongs to the NOP10 family. http://togogenome.org/gene/61853:ASB16 ^@ http://purl.uniprot.org/uniprot/G1R0F9 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/61853:VOPP1 ^@ http://purl.uniprot.org/uniprot/G1RBC4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VOPP1/ECOP family.|||Cytoplasmic vesicle membrane|||Endosome membrane|||Interacts with WWOX (via WW domain).|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/61853:TUBB2A ^@ http://purl.uniprot.org/uniprot/A0A2I3GDI7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/61853:LTN1 ^@ http://purl.uniprot.org/uniprot/G1QRP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LTN1 family.|||Component of the ribosome quality control complex (RQC).|||E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.|||cytosol http://togogenome.org/gene/61853:CFDP1 ^@ http://purl.uniprot.org/uniprot/G1RRE9 ^@ Function|||Subcellular Location Annotation ^@ May play a role during embryogenesis.|||kinetochore http://togogenome.org/gene/61853:TMCC3 ^@ http://purl.uniprot.org/uniprot/G1R1A6 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/61853:RPLP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G4D8 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/61853:EXOC8 ^@ http://purl.uniprot.org/uniprot/G1SB12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EXO84 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||growth cone|||perinuclear region http://togogenome.org/gene/61853:CDH9 ^@ http://purl.uniprot.org/uniprot/G1RN01 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:ACOT4 ^@ http://purl.uniprot.org/uniprot/G1S1S4 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/61853:UFL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HDZ2 ^@ Similarity ^@ Belongs to the UFL1 family. http://togogenome.org/gene/61853:CPEB1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HDJ7|||http://purl.uniprot.org/uniprot/G1RJK7 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/61853:MRPS18A ^@ http://purl.uniprot.org/uniprot/G1QUT7 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/61853:RAB18 ^@ http://purl.uniprot.org/uniprot/A0A2I3HCV8|||http://purl.uniprot.org/uniprot/G1S529 ^@ Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Lipid droplet http://togogenome.org/gene/61853:PMP2 ^@ http://purl.uniprot.org/uniprot/G1QPY0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||May play a role in lipid transport protein in Schwann cells. May bind cholesterol.|||Monomer. http://togogenome.org/gene/61853:GOLPH3L ^@ http://purl.uniprot.org/uniprot/A0A2I3H4Q1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Golgi stack membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/61853:OAZ3 ^@ http://purl.uniprot.org/uniprot/G1RH25 ^@ Similarity ^@ Belongs to the ODC antizyme family. http://togogenome.org/gene/61853:HRH2 ^@ http://purl.uniprot.org/uniprot/G1QIC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:ACMSD ^@ http://purl.uniprot.org/uniprot/G1RAK9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.|||Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.|||Monomer. http://togogenome.org/gene/61853:VAMP3 ^@ http://purl.uniprot.org/uniprot/A0A2I3G5K1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/61853:RPL34 ^@ http://purl.uniprot.org/uniprot/G1RR30 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/61853:GAL3ST1 ^@ http://purl.uniprot.org/uniprot/G1QUU5 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/61853:LOC100602413 ^@ http://purl.uniprot.org/uniprot/G1S9V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:YPEL5 ^@ http://purl.uniprot.org/uniprot/G1RZT5 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/61853:SRD5A3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GNQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).|||Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. http://togogenome.org/gene/61853:NDUFA6 ^@ http://purl.uniprot.org/uniprot/G1S0Z0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:SLC33A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HN55 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:MSX1 ^@ http://purl.uniprot.org/uniprot/G1S212 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:FAM3B ^@ http://purl.uniprot.org/uniprot/A0A2I3HFI4|||http://purl.uniprot.org/uniprot/G1RBB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/61853:LOC100602794 ^@ http://purl.uniprot.org/uniprot/A0A2I3FZX1|||http://purl.uniprot.org/uniprot/G1QQ51 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/61853:AMHR2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HSE3|||http://purl.uniprot.org/uniprot/G1S7I9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane|||On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. http://togogenome.org/gene/61853:GABRA5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GX20 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/61853:C24H1orf158 ^@ http://purl.uniprot.org/uniprot/A0A2I3GCP6|||http://purl.uniprot.org/uniprot/G1RFJ4 ^@ Function|||Subcellular Location Annotation ^@ Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.|||cilium axoneme http://togogenome.org/gene/61853:ACAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HHG2 ^@ Activity Regulation|||Domain|||Function|||Subcellular Location Annotation ^@ Endosome membrane|||GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.|||GTPase-activating protein for the ADP ribosylation factor family.|||PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.|||The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions. http://togogenome.org/gene/61853:DHCR7 ^@ http://purl.uniprot.org/uniprot/A0A2I3G7U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/61853:DGKB ^@ http://purl.uniprot.org/uniprot/G1S2U8 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/61853:CPQ ^@ http://purl.uniprot.org/uniprot/G1QU32 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.|||Endoplasmic reticulum|||Golgi apparatus|||Homodimer. The monomeric form is inactive while the homodimer is active.|||Lysosome http://togogenome.org/gene/61853:GMPPB ^@ http://purl.uniprot.org/uniprot/G1R5D2 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/61853:TBX22 ^@ http://purl.uniprot.org/uniprot/G1QNW5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/61853:S100A8 ^@ http://purl.uniprot.org/uniprot/A0A2I3HUD2 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/61853:FAM241A ^@ http://purl.uniprot.org/uniprot/G1S380 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM241 family.|||Membrane http://togogenome.org/gene/61853:DPYSL3 ^@ http://purl.uniprot.org/uniprot/G1RG10 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/61853:WASL ^@ http://purl.uniprot.org/uniprot/G1RNG4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:STAC3 ^@ http://purl.uniprot.org/uniprot/G1S6D3 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/61853:PCNX2 ^@ http://purl.uniprot.org/uniprot/G1QPU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/61853:EPHA3 ^@ http://purl.uniprot.org/uniprot/G1RM08 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:CREG1 ^@ http://purl.uniprot.org/uniprot/G1RXN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CREG family.|||Secreted http://togogenome.org/gene/61853:BIRC7 ^@ http://purl.uniprot.org/uniprot/G1RG16 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/61853:ORMDL2 ^@ http://purl.uniprot.org/uniprot/G1S767 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/61853:GCFC2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HCE9 ^@ Similarity ^@ Belongs to the GCF family. http://togogenome.org/gene/61853:CHEK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GYB3|||http://purl.uniprot.org/uniprot/G1R7A0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. http://togogenome.org/gene/61853:NAB2 ^@ http://purl.uniprot.org/uniprot/G1S6K2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAB family.|||Homomultimers may associate with EGR1 bound to DNA.|||Nucleus http://togogenome.org/gene/61853:FAM122C ^@ http://purl.uniprot.org/uniprot/A0A2I3HWT6|||http://purl.uniprot.org/uniprot/G1QNL6 ^@ Similarity ^@ Belongs to the FAM122 family. http://togogenome.org/gene/61853:CPA6 ^@ http://purl.uniprot.org/uniprot/G1RJR3 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/61853:NUDT12 ^@ http://purl.uniprot.org/uniprot/G1RK38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Nudix hydrolase family. NudC subfamily.|||Cytoplasmic granule|||Peroxisome http://togogenome.org/gene/61853:GASK1A ^@ http://purl.uniprot.org/uniprot/G1R1Q5 ^@ Similarity ^@ Belongs to the GASK family. http://togogenome.org/gene/61853:ICMT ^@ http://purl.uniprot.org/uniprot/A0A2I3FXC2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.|||Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:PEX2 ^@ http://purl.uniprot.org/uniprot/G1QN94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/61853:GHRH ^@ http://purl.uniprot.org/uniprot/G1R342 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/61853:RPS23 ^@ http://purl.uniprot.org/uniprot/A0A2I3GPZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS12 family.|||Rough endoplasmic reticulum http://togogenome.org/gene/61853:SERPINA1 ^@ http://purl.uniprot.org/uniprot/G1S644 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/61853:C14H2orf68 ^@ http://purl.uniprot.org/uniprot/A0A2I3H392 ^@ Similarity ^@ Belongs to the UPF0561 family. http://togogenome.org/gene/61853:ATP5MG ^@ http://purl.uniprot.org/uniprot/G1R710 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase g subunit family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion http://togogenome.org/gene/61853:SLC45A2 ^@ http://purl.uniprot.org/uniprot/G1RVV2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:CLDN17 ^@ http://purl.uniprot.org/uniprot/G1SA44 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/61853:SEPTIN11 ^@ http://purl.uniprot.org/uniprot/A0A2I3G5C1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/61853:EIF6 ^@ http://purl.uniprot.org/uniprot/G1RGU7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-6 family.|||Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.|||Cytoplasm|||Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).|||Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.|||nucleolus http://togogenome.org/gene/61853:SMUG1 ^@ http://purl.uniprot.org/uniprot/G1S7F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.|||Nucleus http://togogenome.org/gene/61853:B9D1 ^@ http://purl.uniprot.org/uniprot/G1RBT5 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/61853:SLC35A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HTQ1|||http://purl.uniprot.org/uniprot/G1RR48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:GOLT1A ^@ http://purl.uniprot.org/uniprot/G1RVL1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/61853:HAPLN1 ^@ http://purl.uniprot.org/uniprot/G1RSL0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:FAM24B ^@ http://purl.uniprot.org/uniprot/A0A2I3HNE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM24 family.|||Secreted http://togogenome.org/gene/61853:GPX8 ^@ http://purl.uniprot.org/uniprot/G1QKJ2 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/61853:FOXP4 ^@ http://purl.uniprot.org/uniprot/G1QYJ5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:DONSON ^@ http://purl.uniprot.org/uniprot/G1QVE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DONSON family.|||Nucleus http://togogenome.org/gene/61853:RNF10 ^@ http://purl.uniprot.org/uniprot/G1S111 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNF10 family.|||Cytoplasm http://togogenome.org/gene/61853:METTL11B ^@ http://purl.uniprot.org/uniprot/G1RYN4 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/61853:BIRC3 ^@ http://purl.uniprot.org/uniprot/G1R6A7 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/61853:ST3GAL4 ^@ http://purl.uniprot.org/uniprot/G1R7C1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/61853:RGS7BP ^@ http://purl.uniprot.org/uniprot/G1QSM7 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/61853:LOC100598737 ^@ http://purl.uniprot.org/uniprot/A0A2I3GAU9|||http://purl.uniprot.org/uniprot/G1QNP6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:CCN2 ^@ http://purl.uniprot.org/uniprot/G1RWQ1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:MLNR ^@ http://purl.uniprot.org/uniprot/G1QTN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:IL17B ^@ http://purl.uniprot.org/uniprot/A0A2I3G8G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/61853:GPR182 ^@ http://purl.uniprot.org/uniprot/G1S6L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:PDGFRB ^@ http://purl.uniprot.org/uniprot/G1RGZ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Cytoplasmic vesicle|||Interacts with homodimeric PDGFB and PDGFD, and with heterodimers formed by PDGFA and PDGFB.|||Lysosome lumen|||Membrane|||Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.|||Vesicle http://togogenome.org/gene/61853:ZNF768 ^@ http://purl.uniprot.org/uniprot/G1S152 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:CASP5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GJI8|||http://purl.uniprot.org/uniprot/A0A2I3HII9|||http://purl.uniprot.org/uniprot/G1R6F9 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/61853:DPF3 ^@ http://purl.uniprot.org/uniprot/G1QPT3 ^@ Similarity ^@ Belongs to the requiem/DPF family. http://togogenome.org/gene/61853:RAB39A ^@ http://purl.uniprot.org/uniprot/A0A2I3GE23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:RNF4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GX76 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:TMOD2 ^@ http://purl.uniprot.org/uniprot/G1R3T0 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/61853:DEFB128 ^@ http://purl.uniprot.org/uniprot/G1REH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/61853:HARS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GM82|||http://purl.uniprot.org/uniprot/A0A2I3HLE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/61853:DOK2 ^@ http://purl.uniprot.org/uniprot/M3ZA98 ^@ Similarity ^@ Belongs to the DOK family. Type A subfamily. http://togogenome.org/gene/61853:ETFDH ^@ http://purl.uniprot.org/uniprot/G1R3L3 ^@ Cofactor|||Function ^@ Accepts electrons from ETF and reduces ubiquinone.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/61853:MALL ^@ http://purl.uniprot.org/uniprot/A0A2I3FXI9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:CTSL ^@ http://purl.uniprot.org/uniprot/G1R047 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/61853:MED19 ^@ http://purl.uniprot.org/uniprot/A0A2I3HZ58|||http://purl.uniprot.org/uniprot/G1RQS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 19 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/61853:LOC100593802 ^@ http://purl.uniprot.org/uniprot/G1SAV4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:HEBP1 ^@ http://purl.uniprot.org/uniprot/G1QU62 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/61853:NUDT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G317 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family.|||Monomer.|||Nucleus http://togogenome.org/gene/61853:LOC100591611 ^@ http://purl.uniprot.org/uniprot/G1SAC4 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/61853:SI ^@ http://purl.uniprot.org/uniprot/G1QY24 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 31 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:POU2F1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HNQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-2 subfamily.|||Nucleus|||Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. http://togogenome.org/gene/61853:GPR65 ^@ http://purl.uniprot.org/uniprot/G1S4R8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:ZNF287 ^@ http://purl.uniprot.org/uniprot/A0A2I3GRJ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:PLK4 ^@ http://purl.uniprot.org/uniprot/G1RTU0 ^@ Subcellular Location Annotation ^@ Cleavage furrow|||centriole http://togogenome.org/gene/61853:NOP58 ^@ http://purl.uniprot.org/uniprot/G1R5R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus|||nucleoplasm http://togogenome.org/gene/61853:PLA2G4A ^@ http://purl.uniprot.org/uniprot/G1S8S8 ^@ Domain ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding. http://togogenome.org/gene/61853:RAP2A ^@ http://purl.uniprot.org/uniprot/G1R8I3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/61853:DUSP26 ^@ http://purl.uniprot.org/uniprot/A0A2I3HXT4 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/61853:OLFML2B ^@ http://purl.uniprot.org/uniprot/G1RWS1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:DBP ^@ http://purl.uniprot.org/uniprot/G1QX60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/61853:TFB2M ^@ http://purl.uniprot.org/uniprot/G1QVP7 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:MTFR1 ^@ http://purl.uniprot.org/uniprot/G1QV11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/61853:HSPD1 ^@ http://purl.uniprot.org/uniprot/G1R5A6 ^@ Similarity ^@ Belongs to the chaperonin (HSP60) family. http://togogenome.org/gene/61853:GLIS2 ^@ http://purl.uniprot.org/uniprot/G1RFI4 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/61853:PLCB4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GKX5|||http://purl.uniprot.org/uniprot/G1RW33 ^@ Cofactor|||Function ^@ Binds 1 Ca(2+) ion per subunit.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/61853:NSUN7 ^@ http://purl.uniprot.org/uniprot/A0A2I3FZR0|||http://purl.uniprot.org/uniprot/G1S5Q7 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:WNT8B ^@ http://purl.uniprot.org/uniprot/G1RXH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/61853:PKP4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GI20|||http://purl.uniprot.org/uniprot/G1QJM7 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/61853:TMBIM4 ^@ http://purl.uniprot.org/uniprot/G1QSF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/61853:ADK ^@ http://purl.uniprot.org/uniprot/A0A2I3G6Z2|||http://purl.uniprot.org/uniprot/A0A2I3GJH7|||http://purl.uniprot.org/uniprot/A0A2I3GKL9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.|||Belongs to the carbohydrate kinase PfkB family.|||Binds 3 Mg(2+) ions per subunit.|||Monomer.|||Nucleus http://togogenome.org/gene/61853:CALB1 ^@ http://purl.uniprot.org/uniprot/G1QPC5 ^@ Function|||Similarity ^@ Belongs to the calbindin family.|||Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. http://togogenome.org/gene/61853:LOC100586304 ^@ http://purl.uniprot.org/uniprot/G1SC39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:NNAT ^@ http://purl.uniprot.org/uniprot/A0A2I3HMZ0|||http://purl.uniprot.org/uniprot/G1R369 ^@ Similarity ^@ Belongs to the neuronatin family. http://togogenome.org/gene/61853:LOC100595103 ^@ http://purl.uniprot.org/uniprot/G1SC99 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:DSEL ^@ http://purl.uniprot.org/uniprot/G1SA09 ^@ Similarity ^@ Belongs to the dermatan-sulfate isomerase family. http://togogenome.org/gene/61853:IL10 ^@ http://purl.uniprot.org/uniprot/A0A2I3GRH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/61853:ADCK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HXH2|||http://purl.uniprot.org/uniprot/G1S4F5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/61853:KARS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GJB4|||http://purl.uniprot.org/uniprot/G1RRL2 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/61853:DLST ^@ http://purl.uniprot.org/uniprot/G1S2U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/61853:SFXN2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HF35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/61853:SLC22A12 ^@ http://purl.uniprot.org/uniprot/A0A2I3GN75 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:GNAI2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HLR3 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/61853:FAM83C ^@ http://purl.uniprot.org/uniprot/G1RGV3 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/61853:SLC35F4 ^@ http://purl.uniprot.org/uniprot/G1RRE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/61853:REM2 ^@ http://purl.uniprot.org/uniprot/G1RXK5 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/61853:TMEM186 ^@ http://purl.uniprot.org/uniprot/A0A2I3HW99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM186 family.|||Membrane http://togogenome.org/gene/61853:ABCG5 ^@ http://purl.uniprot.org/uniprot/G1S4B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/61853:LOC100591180 ^@ http://purl.uniprot.org/uniprot/A0A2I3HFN4 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/61853:DIMT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H2J0|||http://purl.uniprot.org/uniprot/G1QRZ3 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/61853:LOX ^@ http://purl.uniprot.org/uniprot/G1RMU7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/61853:LOC100580870 ^@ http://purl.uniprot.org/uniprot/A0A2I3H6Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:SERPINB11 ^@ http://purl.uniprot.org/uniprot/A0A2I3GI29|||http://purl.uniprot.org/uniprot/G1RC86 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/61853:PTGDR ^@ http://purl.uniprot.org/uniprot/G1RPH2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:LOC100581154 ^@ http://purl.uniprot.org/uniprot/H9HA21 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/61853:SCGB2A1 ^@ http://purl.uniprot.org/uniprot/G1QTD2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/61853:SLITRK5 ^@ http://purl.uniprot.org/uniprot/G1S3A4 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/61853:SCGN ^@ http://purl.uniprot.org/uniprot/G1QR71 ^@ Subcellular Location Annotation ^@ secretory vesicle membrane http://togogenome.org/gene/61853:CDH10 ^@ http://purl.uniprot.org/uniprot/G1RMW8 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:EFNB1 ^@ http://purl.uniprot.org/uniprot/G1QIU1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:VPS36 ^@ http://purl.uniprot.org/uniprot/A0A2I3HF48|||http://purl.uniprot.org/uniprot/G1S0V0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS36 family.|||Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II).|||Cytoplasm|||Endosome http://togogenome.org/gene/61853:CAPN7 ^@ http://purl.uniprot.org/uniprot/G1QME6 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/61853:LOC100592883 ^@ http://purl.uniprot.org/uniprot/A0A2I3HH44 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:IARS2 ^@ http://purl.uniprot.org/uniprot/G1RUL6 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/61853:HCAR2 ^@ http://purl.uniprot.org/uniprot/A0A4Y1JWQ6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:TACR3 ^@ http://purl.uniprot.org/uniprot/G1RSA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:ABRACL ^@ http://purl.uniprot.org/uniprot/A0A2I3G5U2 ^@ Similarity ^@ Belongs to the costars family. http://togogenome.org/gene/61853:GNRHR ^@ http://purl.uniprot.org/uniprot/G1RD52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:SLC39A2 ^@ http://purl.uniprot.org/uniprot/G1RUZ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:SRP14 ^@ http://purl.uniprot.org/uniprot/A0A2I3G2F2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP14 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm|||Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. http://togogenome.org/gene/61853:RPL29 ^@ http://purl.uniprot.org/uniprot/A0A2I3G942 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL29 family. http://togogenome.org/gene/61853:MSMP ^@ http://purl.uniprot.org/uniprot/G1QVN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/61853:INSL4 ^@ http://purl.uniprot.org/uniprot/G1RCJ2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/61853:CALHM6 ^@ http://purl.uniprot.org/uniprot/A0A2I3G904 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/61853:C14H2orf49 ^@ http://purl.uniprot.org/uniprot/A0A2I3GXX3|||http://purl.uniprot.org/uniprot/A0A2I3HNK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ashwin family.|||Nucleus http://togogenome.org/gene/61853:TM4SF1 ^@ http://purl.uniprot.org/uniprot/G1QRX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/61853:SLC1A4 ^@ http://purl.uniprot.org/uniprot/G1RFV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/61853:PIM2 ^@ http://purl.uniprot.org/uniprot/G1R8Y1 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.|||Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. http://togogenome.org/gene/61853:NUS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GTR9 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/61853:TUBAL3 ^@ http://purl.uniprot.org/uniprot/G1RKQ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/61853:ACTL6B ^@ http://purl.uniprot.org/uniprot/G1RMK5 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/61853:KCNG1 ^@ http://purl.uniprot.org/uniprot/G1R5R7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:TBXAS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HV47 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/61853:TAMM41 ^@ http://purl.uniprot.org/uniprot/A0A2I3GLS3|||http://purl.uniprot.org/uniprot/G1QX72 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAM41 family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:ZNF687 ^@ http://purl.uniprot.org/uniprot/G1RGN5 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/61853:F10 ^@ http://purl.uniprot.org/uniprot/G1QI58 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:MAP4K3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HT86|||http://purl.uniprot.org/uniprot/G1S3J1 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. http://togogenome.org/gene/61853:LEPR ^@ http://purl.uniprot.org/uniprot/A0A2I3H2H9|||http://purl.uniprot.org/uniprot/A0A2I3HGX7|||http://purl.uniprot.org/uniprot/G1RYZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/61853:ESR2 ^@ http://purl.uniprot.org/uniprot/A0A2I3H3K6|||http://purl.uniprot.org/uniprot/A0A2I3HIJ7|||http://purl.uniprot.org/uniprot/G1RVD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/61853:SYCE1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GZP3|||http://purl.uniprot.org/uniprot/G1QQH7 ^@ Similarity ^@ Belongs to the SYCE family. http://togogenome.org/gene/61853:PDK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GW49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/61853:SLC52A3 ^@ http://purl.uniprot.org/uniprot/G1RE05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/61853:INPP4B ^@ http://purl.uniprot.org/uniprot/G1QZT9 ^@ Similarity ^@ Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. http://togogenome.org/gene/61853:INO80C ^@ http://purl.uniprot.org/uniprot/A0A2I3GTU0|||http://purl.uniprot.org/uniprot/A0A2I3HZT3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:RPP30 ^@ http://purl.uniprot.org/uniprot/G1RP82 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 3 family. http://togogenome.org/gene/61853:ATG16L2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HC25 ^@ Similarity ^@ Belongs to the WD repeat ATG16 family. http://togogenome.org/gene/61853:INHBA ^@ http://purl.uniprot.org/uniprot/G1QS95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/61853:TEKT2 ^@ http://purl.uniprot.org/uniprot/G1RKB9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/61853:KCND3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GHZ2|||http://purl.uniprot.org/uniprot/G1QVI2 ^@ Subcellular Location Annotation ^@ Membrane|||dendrite http://togogenome.org/gene/61853:CDNF ^@ http://purl.uniprot.org/uniprot/G1RND0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARMET family.|||Secreted http://togogenome.org/gene/61853:C12H1orf43 ^@ http://purl.uniprot.org/uniprot/A0A2I3GR63|||http://purl.uniprot.org/uniprot/A0A2I3GY57 ^@ Function|||Subcellular Location Annotation ^@ General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.|||Golgi apparatus|||Membrane|||Mitochondrion http://togogenome.org/gene/61853:SLC25A20 ^@ http://purl.uniprot.org/uniprot/A0A2I3H4B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/61853:NSUN4 ^@ http://purl.uniprot.org/uniprot/G1S3E8 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/61853:TPRG1L ^@ http://purl.uniprot.org/uniprot/A0A2I3GEA5 ^@ Similarity ^@ Belongs to the TPRG1 family. http://togogenome.org/gene/61853:GNPAT ^@ http://purl.uniprot.org/uniprot/G1QNI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Peroxisome membrane http://togogenome.org/gene/61853:SLC25A42 ^@ http://purl.uniprot.org/uniprot/A0A2I3GNQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/61853:CENPU ^@ http://purl.uniprot.org/uniprot/G1RJI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-U/AME1 family.|||Nucleus http://togogenome.org/gene/61853:SEMA6D ^@ http://purl.uniprot.org/uniprot/A0A2I3H4E0|||http://purl.uniprot.org/uniprot/A0A2I3HDC8|||http://purl.uniprot.org/uniprot/G1R1V9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:MUS81 ^@ http://purl.uniprot.org/uniprot/G1R1P5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPF family.|||Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).|||Interacts with EME1.|||Nucleus http://togogenome.org/gene/61853:PPM1N ^@ http://purl.uniprot.org/uniprot/G1QP08 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/61853:DNAL4 ^@ http://purl.uniprot.org/uniprot/G1RYX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/61853:CCN3 ^@ http://purl.uniprot.org/uniprot/G1QYD1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:MFRP ^@ http://purl.uniprot.org/uniprot/G1R747 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:PPP1R3B ^@ http://purl.uniprot.org/uniprot/A0A2I3HE44 ^@ Subunit ^@ Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity. http://togogenome.org/gene/61853:EXOC4 ^@ http://purl.uniprot.org/uniprot/G1RR97 ^@ Function|||Similarity ^@ Belongs to the SEC8 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/61853:AMZ1 ^@ http://purl.uniprot.org/uniprot/G1RI59 ^@ Function|||Similarity ^@ Belongs to the peptidase M54 family.|||Probable zinc metalloprotease. http://togogenome.org/gene/61853:ADAM23 ^@ http://purl.uniprot.org/uniprot/A0A2I3GIB3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:PDE1B ^@ http://purl.uniprot.org/uniprot/A0A2I3GV81|||http://purl.uniprot.org/uniprot/G1S7A7 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/61853:P2RX6 ^@ http://purl.uniprot.org/uniprot/G1R9A7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/61853:TLX2 ^@ http://purl.uniprot.org/uniprot/G1QIZ5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:CHD7 ^@ http://purl.uniprot.org/uniprot/A0A2I3GT41 ^@ Similarity ^@ Belongs to the SNF2/RAD54 helicase family. http://togogenome.org/gene/61853:VPS33A ^@ http://purl.uniprot.org/uniprot/G1QLL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Early endosome|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||clathrin-coated vesicle http://togogenome.org/gene/61853:EXOC2 ^@ http://purl.uniprot.org/uniprot/G1RIT9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SEC5 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||Component of the exocyst complex. http://togogenome.org/gene/61853:CEP19 ^@ http://purl.uniprot.org/uniprot/M3Z926 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP19 family.|||centriole|||cilium basal body|||spindle pole http://togogenome.org/gene/61853:NXPH2 ^@ http://purl.uniprot.org/uniprot/G1RCC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/61853:RBM15 ^@ http://purl.uniprot.org/uniprot/G1QTT0 ^@ Similarity ^@ Belongs to the RRM Spen family. http://togogenome.org/gene/61853:GLP2R ^@ http://purl.uniprot.org/uniprot/G1RGH0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:GCLM ^@ http://purl.uniprot.org/uniprot/G1RJ06 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.|||Heterodimer of a catalytic heavy chain and a regulatory light chain. http://togogenome.org/gene/61853:LSM6 ^@ http://purl.uniprot.org/uniprot/G1R0N6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/61853:PLD5 ^@ http://purl.uniprot.org/uniprot/G1QUP8 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/61853:TPT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G3E2 ^@ Similarity ^@ Belongs to the TCTP family. http://togogenome.org/gene/61853:CCNT2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GEQ2|||http://purl.uniprot.org/uniprot/G1RAP6 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/61853:KCNV2 ^@ http://purl.uniprot.org/uniprot/G1RBL7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:EPGN ^@ http://purl.uniprot.org/uniprot/A0A2I3HWG5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:GET1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HMJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WRB/GET1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:DKC1 ^@ http://purl.uniprot.org/uniprot/G1RW04 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/61853:CELF6 ^@ http://purl.uniprot.org/uniprot/A0A2I3HP85|||http://purl.uniprot.org/uniprot/G1RUL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Nucleus http://togogenome.org/gene/61853:FRAT2 ^@ http://purl.uniprot.org/uniprot/G1SBR4 ^@ Similarity ^@ Belongs to the GSK-3-binding protein family. http://togogenome.org/gene/61853:VPS37A ^@ http://purl.uniprot.org/uniprot/A0A2I3GTP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/61853:CACFD1 ^@ http://purl.uniprot.org/uniprot/G1RS36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel flower family.|||Membrane http://togogenome.org/gene/61853:FGGY ^@ http://purl.uniprot.org/uniprot/G1RXL6 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/61853:GADD45G ^@ http://purl.uniprot.org/uniprot/G1QHZ9 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/61853:LCN10 ^@ http://purl.uniprot.org/uniprot/A0A2I3H5U3|||http://purl.uniprot.org/uniprot/G1RAE5 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/61853:TAS2R3 ^@ http://purl.uniprot.org/uniprot/G1S9X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/61853:H1-4 ^@ http://purl.uniprot.org/uniprot/G1S9R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/61853:COPS7B ^@ http://purl.uniprot.org/uniprot/A0A2I3H3Q9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:MPDU1 ^@ http://purl.uniprot.org/uniprot/G1REV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:GSC ^@ http://purl.uniprot.org/uniprot/G1S677 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:PPP3R1 ^@ http://purl.uniprot.org/uniprot/G1RG24 ^@ Similarity ^@ Belongs to the calcineurin regulatory subunit family. http://togogenome.org/gene/61853:SLC46A3 ^@ http://purl.uniprot.org/uniprot/G1QIG6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:CCDC103 ^@ http://purl.uniprot.org/uniprot/G1QZC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC103/PR46b family.|||Cytoplasm|||Dynein-attachment factor required for cilia motility.|||Homodimer.|||flagellum http://togogenome.org/gene/61853:PMEL ^@ http://purl.uniprot.org/uniprot/A0A2I3H627 ^@ Similarity ^@ Belongs to the PMEL/NMB family. http://togogenome.org/gene/61853:PDGFD ^@ http://purl.uniprot.org/uniprot/A0A2I3FTG5 ^@ Caution|||Similarity ^@ Belongs to the PDGF/VEGF growth factor family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:TMTC3 ^@ http://purl.uniprot.org/uniprot/G1R0B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/61853:ITM2A ^@ http://purl.uniprot.org/uniprot/G1QIT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/61853:SAG ^@ http://purl.uniprot.org/uniprot/A0A2I3H239 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/61853:KIF21A ^@ http://purl.uniprot.org/uniprot/A0A2I3GGY9|||http://purl.uniprot.org/uniprot/A0A2I3HIM4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/61853:PRPF19 ^@ http://purl.uniprot.org/uniprot/A0A2I3GKY0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat PRP19 family.|||Homotetramer.|||Lipid droplet|||Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.|||nucleoplasm http://togogenome.org/gene/61853:THAP10 ^@ http://purl.uniprot.org/uniprot/G1RTN2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THAP1 family.|||DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.|||Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.|||nucleoplasm http://togogenome.org/gene/61853:RELL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HXU9 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/61853:CSTA ^@ http://purl.uniprot.org/uniprot/G1QHF2 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/61853:CBLIF ^@ http://purl.uniprot.org/uniprot/G1RRT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/61853:TBX19 ^@ http://purl.uniprot.org/uniprot/G1RY22 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/61853:IFITM5 ^@ http://purl.uniprot.org/uniprot/G1R9V0 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/61853:CTNS ^@ http://purl.uniprot.org/uniprot/G1S613 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cystinosin family.|||Membrane http://togogenome.org/gene/61853:KIFC1 ^@ http://purl.uniprot.org/uniprot/G1RA63 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/61853:KCNQ5 ^@ http://purl.uniprot.org/uniprot/A0A2I3HKC3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:DIAPH2 ^@ http://purl.uniprot.org/uniprot/G1QJL9 ^@ Similarity ^@ Belongs to the formin homology family. Diaphanous subfamily. http://togogenome.org/gene/61853:HTR1F ^@ http://purl.uniprot.org/uniprot/G1SAH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.|||Membrane http://togogenome.org/gene/61853:RPL26 ^@ http://purl.uniprot.org/uniprot/G1RG12 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/61853:RND3 ^@ http://purl.uniprot.org/uniprot/G1RIZ5 ^@ Function ^@ Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. http://togogenome.org/gene/61853:OCIAD1 ^@ http://purl.uniprot.org/uniprot/A0A2I3FYY1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OCIAD1 family.|||Endosome|||Interacts with STAT3.|||Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.|||The OCIA domain is necessary and sufficient for endosomal localization. http://togogenome.org/gene/61853:OGN ^@ http://purl.uniprot.org/uniprot/G1S342 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/61853:MAEL ^@ http://purl.uniprot.org/uniprot/A0A2I3GEV4|||http://purl.uniprot.org/uniprot/G1RXJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the maelstrom family.|||Nucleus|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage. http://togogenome.org/gene/61853:GLRA3 ^@ http://purl.uniprot.org/uniprot/A0A2I3FZL0|||http://purl.uniprot.org/uniprot/G1R4P9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/61853:MYCL ^@ http://purl.uniprot.org/uniprot/G1RN33 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/61853:TXLNB ^@ http://purl.uniprot.org/uniprot/G1RYF8 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/61853:DDX55 ^@ http://purl.uniprot.org/uniprot/A0A2I3GTY0 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/61853:AASDHPPT ^@ http://purl.uniprot.org/uniprot/G1R6H1 ^@ Similarity ^@ Belongs to the P-Pant transferase superfamily. AcpS family. http://togogenome.org/gene/61853:SPINK4 ^@ http://purl.uniprot.org/uniprot/G1QZD1 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/61853:LOC100607627 ^@ http://purl.uniprot.org/uniprot/G1S6V7 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/61853:DEFB126 ^@ http://purl.uniprot.org/uniprot/G1REI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/61853:LIPA ^@ http://purl.uniprot.org/uniprot/A0A2I3GTS6 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/61853:SELENOS ^@ http://purl.uniprot.org/uniprot/G1QHV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selenoprotein S family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.|||Membrane http://togogenome.org/gene/61853:RAD21L1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HZL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/61853:SPESP1 ^@ http://purl.uniprot.org/uniprot/G1RSK0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPESP1 family.|||Involved in fertilization ability of sperm.|||acrosome http://togogenome.org/gene/61853:LOXL3 ^@ http://purl.uniprot.org/uniprot/A0A2I3FYI9 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/61853:POLR3K ^@ http://purl.uniprot.org/uniprot/G1R900 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/61853:NRN1L ^@ http://purl.uniprot.org/uniprot/G1QYN5 ^@ Similarity ^@ Belongs to the neuritin family. http://togogenome.org/gene/61853:PARPBP ^@ http://purl.uniprot.org/uniprot/G1R3J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PARI family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:DDX1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HKV9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DDX1 subfamily.|||Cytoplasmic granule|||RNA helicase.|||The helicase domain is involved in the stimulation of RELA transcriptional activity. http://togogenome.org/gene/61853:PPM1G ^@ http://purl.uniprot.org/uniprot/G1QTW4 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/61853:IMPDH2 ^@ http://purl.uniprot.org/uniprot/G1R4U5 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.|||Nucleus http://togogenome.org/gene/61853:CCT4 ^@ http://purl.uniprot.org/uniprot/G1RF78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/61853:APH1A ^@ http://purl.uniprot.org/uniprot/G1RFG4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. http://togogenome.org/gene/61853:STK32A ^@ http://purl.uniprot.org/uniprot/A0A2I3G4Q9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:SLC50A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GEF2|||http://purl.uniprot.org/uniprot/A0A2I3GUN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SWEET sugar transporter family.|||Cell membrane|||Golgi apparatus membrane|||Mediates sugar transport across membranes.|||Membrane http://togogenome.org/gene/61853:DEFB118 ^@ http://purl.uniprot.org/uniprot/G1REI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/61853:LYPD2 ^@ http://purl.uniprot.org/uniprot/G1QKT9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:LOC100605289 ^@ http://purl.uniprot.org/uniprot/G1SBD3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:DKK4 ^@ http://purl.uniprot.org/uniprot/G1RQY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/61853:SHTN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GPB6|||http://purl.uniprot.org/uniprot/G1S3J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shootin family.|||Perikaryon|||axon|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/61853:SEH1L ^@ http://purl.uniprot.org/uniprot/G1RCZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.|||Lysosome membrane|||kinetochore http://togogenome.org/gene/61853:BEST3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GBC9|||http://purl.uniprot.org/uniprot/A0A2I3H7E5|||http://purl.uniprot.org/uniprot/G1QV48 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/61853:SMARCA5 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.|||Nucleus http://togogenome.org/gene/61853:SLC30A6 ^@ http://purl.uniprot.org/uniprot/A0A2I3H1X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/61853:DICER1 ^@ http://purl.uniprot.org/uniprot/G1S694 ^@ Function|||Similarity ^@ Belongs to the helicase family. Dicer subfamily.|||Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. http://togogenome.org/gene/61853:LOC100596435 ^@ http://purl.uniprot.org/uniprot/G1RWL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lambda interferon family.|||Secreted http://togogenome.org/gene/61853:SLC13A1 ^@ http://purl.uniprot.org/uniprot/G1RN91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/61853:RPL31 ^@ http://purl.uniprot.org/uniprot/A0A2I3H4T1 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL31 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/61853:LSM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HZW8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Cytoplasm|||Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.|||P-body|||Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. http://togogenome.org/gene/61853:ARHGDIB ^@ http://purl.uniprot.org/uniprot/G1QV75 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/61853:CCR4 ^@ http://purl.uniprot.org/uniprot/G1SA82 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:IL21 ^@ http://purl.uniprot.org/uniprot/G1RE48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/61853:GDI1 ^@ http://purl.uniprot.org/uniprot/G1RVP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/61853:EMP3 ^@ http://purl.uniprot.org/uniprot/G1QWG1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Probably involved in cell proliferation and cell-cell interactions. http://togogenome.org/gene/61853:ADGRG2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G4P7|||http://purl.uniprot.org/uniprot/A0A2I3GCH3|||http://purl.uniprot.org/uniprot/A0A2I3HP76|||http://purl.uniprot.org/uniprot/A0A2I3HQB7|||http://purl.uniprot.org/uniprot/G1RFD9|||http://purl.uniprot.org/uniprot/M3Z9Q2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:AVL9 ^@ http://purl.uniprot.org/uniprot/A0A2I3GG82|||http://purl.uniprot.org/uniprot/A0A2I3GWC6 ^@ Subcellular Location Annotation ^@ Recycling endosome http://togogenome.org/gene/61853:LIN7A ^@ http://purl.uniprot.org/uniprot/A0A2I3GAM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.|||Postsynaptic density membrane|||tight junction http://togogenome.org/gene/61853:GABRA6 ^@ http://purl.uniprot.org/uniprot/G1QX18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/61853:WNT6 ^@ http://purl.uniprot.org/uniprot/G1RCK4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/61853:KIF14 ^@ http://purl.uniprot.org/uniprot/G1S8W4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/61853:UPK1B ^@ http://purl.uniprot.org/uniprot/G1QY17 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:NAP1L4 ^@ http://purl.uniprot.org/uniprot/A0A2I3H9V7|||http://purl.uniprot.org/uniprot/G1RJ50 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/61853:PEX5L ^@ http://purl.uniprot.org/uniprot/A0A2I3GSI6|||http://purl.uniprot.org/uniprot/A0A2I3GWU3|||http://purl.uniprot.org/uniprot/A0A2I3GXC7|||http://purl.uniprot.org/uniprot/A0A2I3HSL8|||http://purl.uniprot.org/uniprot/G1R1R4 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/61853:DMAP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GJZ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:FLAD1 ^@ http://purl.uniprot.org/uniprot/G1RLG1 ^@ Function|||Similarity ^@ Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.|||In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.|||In the N-terminal section; belongs to the MoaB/Mog family. http://togogenome.org/gene/61853:SLC25A13 ^@ http://purl.uniprot.org/uniprot/G1S1K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:MZT1 ^@ http://purl.uniprot.org/uniprot/G1S1L7 ^@ Function|||Similarity ^@ Belongs to the MOZART1 family.|||Required for gamma-tubulin complex recruitment to the centrosome. http://togogenome.org/gene/61853:FDFT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HU46 ^@ Function|||Similarity ^@ Belongs to the phytoene/squalene synthase family.|||Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. http://togogenome.org/gene/61853:PRKAA2 ^@ http://purl.uniprot.org/uniprot/G1RX86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:WDR83OS ^@ http://purl.uniprot.org/uniprot/G1RQA1 ^@ Similarity ^@ Belongs to the Asterix family. http://togogenome.org/gene/61853:COMTD1 ^@ http://purl.uniprot.org/uniprot/G1S4R3 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/61853:CFAP299 ^@ http://purl.uniprot.org/uniprot/A0A2I3H0W8|||http://purl.uniprot.org/uniprot/A0A2I3HPQ5 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in spermatogenesis.|||Nucleus http://togogenome.org/gene/61853:HIF3A ^@ http://purl.uniprot.org/uniprot/A0A2I3HJJ6|||http://purl.uniprot.org/uniprot/G1QQE6 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/61853:TBK1 ^@ http://purl.uniprot.org/uniprot/G1S5B9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:LOC100606376 ^@ http://purl.uniprot.org/uniprot/G1QZU8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/61853:LOC100581638 ^@ http://purl.uniprot.org/uniprot/A0A2I3HRS3 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/61853:OLFML2A ^@ http://purl.uniprot.org/uniprot/A0A2I3H4S1|||http://purl.uniprot.org/uniprot/G1S661 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:SSRP1 ^@ http://purl.uniprot.org/uniprot/G1RPY1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSRP1 family.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Nucleus http://togogenome.org/gene/61853:RHO ^@ http://purl.uniprot.org/uniprot/G1QZM3 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Contains one covalently linked retinal chromophore.|||Membrane http://togogenome.org/gene/61853:MANEA ^@ http://purl.uniprot.org/uniprot/G1RSS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:BST1 ^@ http://purl.uniprot.org/uniprot/G1S308 ^@ Similarity ^@ Belongs to the ADP-ribosyl cyclase family. http://togogenome.org/gene/61853:LOC100583507 ^@ http://purl.uniprot.org/uniprot/G1R963 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/61853:FUCA2 ^@ http://purl.uniprot.org/uniprot/G1RYM4 ^@ Function|||Similarity|||Subunit ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family.|||Homotetramer. http://togogenome.org/gene/61853:RAB21 ^@ http://purl.uniprot.org/uniprot/G1QWN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cleavage furrow|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||trans-Golgi network http://togogenome.org/gene/61853:GALR2 ^@ http://purl.uniprot.org/uniprot/G1QNH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/61853:NTMT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GVK4 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/61853:NUP205 ^@ http://purl.uniprot.org/uniprot/G1RT58 ^@ Similarity ^@ Belongs to the NUP186/NUP192/NUP205 family. http://togogenome.org/gene/61853:FZD5 ^@ http://purl.uniprot.org/uniprot/A0A2I3HUS3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:PSMD12 ^@ http://purl.uniprot.org/uniprot/A0A2I3HX67 ^@ Similarity ^@ Belongs to the proteasome subunit p55 family. http://togogenome.org/gene/61853:PCSK2 ^@ http://purl.uniprot.org/uniprot/G1REW0 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/61853:LOC100582529 ^@ http://purl.uniprot.org/uniprot/G1S6C7 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/61853:BEX1 ^@ http://purl.uniprot.org/uniprot/G1SA99 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/61853:PAX3 ^@ http://purl.uniprot.org/uniprot/G1REQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/61853:LYG1 ^@ http://purl.uniprot.org/uniprot/G1QNW9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 23 family. http://togogenome.org/gene/61853:TM6SF1 ^@ http://purl.uniprot.org/uniprot/G1RJ34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TM6SF family.|||Membrane http://togogenome.org/gene/61853:SYNDIG1L ^@ http://purl.uniprot.org/uniprot/G1S2H5 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/61853:CPO ^@ http://purl.uniprot.org/uniprot/G1R656 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/61853:YWHAE ^@ http://purl.uniprot.org/uniprot/A0A2I3HHF3 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/61853:DEFB123 ^@ http://purl.uniprot.org/uniprot/G1REJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/61853:ELF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G750|||http://purl.uniprot.org/uniprot/A0A2I3GTY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/61853:GDF9 ^@ http://purl.uniprot.org/uniprot/G1RQV5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.|||Secreted http://togogenome.org/gene/61853:NME3 ^@ http://purl.uniprot.org/uniprot/G1RBT7 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/61853:LIPC ^@ http://purl.uniprot.org/uniprot/A0A2I3G381 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:ATP6V1A ^@ http://purl.uniprot.org/uniprot/G1QXI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Vesicle|||clathrin-coated vesicle membrane|||secretory vesicle http://togogenome.org/gene/61853:PPP2R5A ^@ http://purl.uniprot.org/uniprot/A0A2I3GXD4 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/61853:UBE2A ^@ http://purl.uniprot.org/uniprot/H9H9Y4 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/61853:NR5A1 ^@ http://purl.uniprot.org/uniprot/G1S650 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/61853:MARVELD2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HAC0|||http://purl.uniprot.org/uniprot/G1QW31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/61853:MS4A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GK71 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/61853:SEPSECS ^@ http://purl.uniprot.org/uniprot/G1S4G9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SepSecS family.|||Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.|||Cytoplasm|||Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer. http://togogenome.org/gene/61853:ATP2A2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HQE6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/61853:LOC100598768 ^@ http://purl.uniprot.org/uniprot/G1RYB4 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/61853:UTS2R ^@ http://purl.uniprot.org/uniprot/G1SAZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.|||Membrane http://togogenome.org/gene/61853:USP11 ^@ http://purl.uniprot.org/uniprot/A0A2I3G364 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Nucleus http://togogenome.org/gene/61853:PRPS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3FSD8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/61853:CEP57 ^@ http://purl.uniprot.org/uniprot/G1R671 ^@ Similarity ^@ Belongs to the translokin family. http://togogenome.org/gene/61853:C22AH2orf88 ^@ http://purl.uniprot.org/uniprot/G1R4G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small membrane AKAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:SRP9 ^@ http://purl.uniprot.org/uniprot/G1RTT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP9 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm http://togogenome.org/gene/61853:TWSG1 ^@ http://purl.uniprot.org/uniprot/G1R5J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the twisted gastrulation protein family.|||Secreted http://togogenome.org/gene/61853:FAM187B ^@ http://purl.uniprot.org/uniprot/G1RJP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM187 family.|||Membrane http://togogenome.org/gene/61853:ATL3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HXG9 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/61853:CYLD ^@ http://purl.uniprot.org/uniprot/G1QJS9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||centrosome|||cilium basal body|||perinuclear region|||spindle http://togogenome.org/gene/61853:HTR4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GKC8|||http://purl.uniprot.org/uniprot/A0A2I3GM95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Endosome|||Membrane|||This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. http://togogenome.org/gene/61853:NPM3 ^@ http://purl.uniprot.org/uniprot/A0A2I3FYH6 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/61853:LOC100580067 ^@ http://purl.uniprot.org/uniprot/A0A2I3GR70 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:PIGU ^@ http://purl.uniprot.org/uniprot/A0A2I3G943 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGU family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:LOC100581237 ^@ http://purl.uniprot.org/uniprot/G1RBS8 ^@ Similarity ^@ Belongs to the ficolin lectin family. http://togogenome.org/gene/61853:PHF10 ^@ http://purl.uniprot.org/uniprot/A0A2I3GQF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAYP family.|||Nucleus http://togogenome.org/gene/61853:AGK ^@ http://purl.uniprot.org/uniprot/A0A2I3H099 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AGK family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/61853:RAB39B ^@ http://purl.uniprot.org/uniprot/G1RWL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:NOP53 ^@ http://purl.uniprot.org/uniprot/G1QT31 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP53 family.|||May play a role in ribosome biogenesis.|||nucleolus|||nucleoplasm http://togogenome.org/gene/61853:MTMR6 ^@ http://purl.uniprot.org/uniprot/A0A2I3HPM5 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/61853:MFSD14B ^@ http://purl.uniprot.org/uniprot/G1S3X9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/61853:HIGD1B ^@ http://purl.uniprot.org/uniprot/G1QZE2 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/61853:OLFM3 ^@ http://purl.uniprot.org/uniprot/A0A2I3G6B1|||http://purl.uniprot.org/uniprot/G1RMV4 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/61853:SLC25A51 ^@ http://purl.uniprot.org/uniprot/A0A2I3HZZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/61853:LOC100600510 ^@ http://purl.uniprot.org/uniprot/G1RKC0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/61853:PDCL3 ^@ http://purl.uniprot.org/uniprot/G1RW77 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/61853:TYROBP ^@ http://purl.uniprot.org/uniprot/G1RLK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TYROBP family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:APOOL ^@ http://purl.uniprot.org/uniprot/G1QQH9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:SOAT2 ^@ http://purl.uniprot.org/uniprot/G1S7L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:TLCD4 ^@ http://purl.uniprot.org/uniprot/G1RK96 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:MSL3 ^@ http://purl.uniprot.org/uniprot/G1RCV6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:MALSU1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GFU4 ^@ Similarity ^@ Belongs to the Iojap/RsfS family. http://togogenome.org/gene/61853:EMC3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HHM0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC3 family.|||Component of the ER membrane protein complex (EMC).|||Membrane http://togogenome.org/gene/61853:EIF4E2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GL96|||http://purl.uniprot.org/uniprot/A0A2I3H4M1|||http://purl.uniprot.org/uniprot/A0A2I3HUT2 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/61853:TRPC7 ^@ http://purl.uniprot.org/uniprot/A0A2I3G2F8|||http://purl.uniprot.org/uniprot/A0A2I3H5B3|||http://purl.uniprot.org/uniprot/A0A2I3HRP5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:CCS ^@ http://purl.uniprot.org/uniprot/A0A2I3GTU8 ^@ Similarity ^@ In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family. http://togogenome.org/gene/61853:KATNAL1 ^@ http://purl.uniprot.org/uniprot/G1QIT4 ^@ Activity Regulation|||Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||Cytoplasm|||Interacts with KATNB1 and KATNBL1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Midbody|||Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.|||Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.|||The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.|||Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/61853:PTGER3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GL65|||http://purl.uniprot.org/uniprot/A0A2I3HLL7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:SIGMAR1 ^@ http://purl.uniprot.org/uniprot/G1QY61 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ERG2 family.|||Cell junction|||Cytoplasmic vesicle|||Endoplasmic reticulum membrane|||Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.|||Homotrimer.|||Lipid droplet|||Membrane|||Nucleus envelope|||Nucleus inner membrane|||Nucleus outer membrane|||Postsynaptic density membrane|||The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.|||Vesicle|||growth cone http://togogenome.org/gene/61853:ADAM17 ^@ http://purl.uniprot.org/uniprot/G1RT07 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:AKR1D1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H2T0|||http://purl.uniprot.org/uniprot/A0A2I3HY67|||http://purl.uniprot.org/uniprot/G1RTU2 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/61853:GAB1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GSD3|||http://purl.uniprot.org/uniprot/G1QZZ2 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/61853:SYPL2 ^@ http://purl.uniprot.org/uniprot/G1QRC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/61853:AVP ^@ http://purl.uniprot.org/uniprot/G1R7N5 ^@ Similarity ^@ Belongs to the vasopressin/oxytocin family. http://togogenome.org/gene/61853:SLC25A24 ^@ http://purl.uniprot.org/uniprot/G1QLM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:FZD4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GWH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:BLOC1S5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GSF6 ^@ Function|||Similarity ^@ Belongs to the BLOC1S5 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). http://togogenome.org/gene/61853:ZNF18 ^@ http://purl.uniprot.org/uniprot/G1RWP5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:TOR3A ^@ http://purl.uniprot.org/uniprot/G1S088 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. Torsin subfamily. http://togogenome.org/gene/61853:LOC100594283 ^@ http://purl.uniprot.org/uniprot/A0A2I3GMF3 ^@ Similarity ^@ Belongs to the calcitonin family. http://togogenome.org/gene/61853:FOLH1B ^@ http://purl.uniprot.org/uniprot/A0A2I3GIK2|||http://purl.uniprot.org/uniprot/A0A2I3HYJ9|||http://purl.uniprot.org/uniprot/G1S1J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:BCAS2 ^@ http://purl.uniprot.org/uniprot/G1QXT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPF27 family.|||Nucleus http://togogenome.org/gene/61853:KBTBD8 ^@ http://purl.uniprot.org/uniprot/G1R7K2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KBTBD8 family.|||Golgi apparatus|||spindle http://togogenome.org/gene/61853:TRABD2A ^@ http://purl.uniprot.org/uniprot/A0A2I3HL05|||http://purl.uniprot.org/uniprot/A0A2I3HV12|||http://purl.uniprot.org/uniprot/G1QL35 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TIKI family.|||Cell membrane|||Divalent metal cations. Mn(2+) or Co(2+).|||Membrane|||Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. http://togogenome.org/gene/61853:NFXL1 ^@ http://purl.uniprot.org/uniprot/G1S6E2 ^@ Similarity ^@ Belongs to the NFX1 family. http://togogenome.org/gene/61853:ATXN1 ^@ http://purl.uniprot.org/uniprot/G1QJZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATXN1 family.|||Nucleus http://togogenome.org/gene/61853:CCN6 ^@ http://purl.uniprot.org/uniprot/A0A2I3GDJ0|||http://purl.uniprot.org/uniprot/G1RR76 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:ARFGEF2 ^@ http://purl.uniprot.org/uniprot/G1R5J0 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||perinuclear region http://togogenome.org/gene/61853:SLC4A7 ^@ http://purl.uniprot.org/uniprot/A0A2I3GIX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:SLC25A45 ^@ http://purl.uniprot.org/uniprot/A0A2I3G1U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/61853:NFIA ^@ http://purl.uniprot.org/uniprot/G1RXR6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/61853:DEFB121 ^@ http://purl.uniprot.org/uniprot/G1REJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/61853:DYDC1 ^@ http://purl.uniprot.org/uniprot/G1RIF8 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/61853:LAPTM4A ^@ http://purl.uniprot.org/uniprot/G1QPS8 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/61853:KCNK6 ^@ http://purl.uniprot.org/uniprot/G1S4T6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/61853:LOC100593539 ^@ http://purl.uniprot.org/uniprot/A0A2I3GQ73 ^@ Function|||Similarity ^@ Belongs to the PET191 family.|||Involved in an early step of the mitochondrial complex IV assembly process. http://togogenome.org/gene/61853:CRABP2 ^@ http://purl.uniprot.org/uniprot/G1RQE4 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/61853:OS9 ^@ http://purl.uniprot.org/uniprot/A0A2I3GEX9|||http://purl.uniprot.org/uniprot/A0A2I3HFV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OS-9 family.|||Endoplasmic reticulum lumen|||Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation. http://togogenome.org/gene/61853:DNASE2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GU79 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/61853:CA3 ^@ http://purl.uniprot.org/uniprot/G1QRJ5 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/61853:SLC5A4 ^@ http://purl.uniprot.org/uniprot/G1RVE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:FGD4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HV53 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/61853:GNPNAT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H4V7 ^@ Similarity|||Subunit ^@ Belongs to the acetyltransferase family. GNA1 subfamily.|||Homodimer. http://togogenome.org/gene/61853:PSMB6 ^@ http://purl.uniprot.org/uniprot/A0A2I3HD72 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:BRMS1 ^@ http://purl.uniprot.org/uniprot/G1R2G4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:EIF5 ^@ http://purl.uniprot.org/uniprot/A0A2I3G3H3 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/61853:MCM7 ^@ http://purl.uniprot.org/uniprot/G1RL67 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/61853:FAM124B ^@ http://purl.uniprot.org/uniprot/G1RF52 ^@ Similarity ^@ Belongs to the FAM124 family. http://togogenome.org/gene/61853:MMGT1 ^@ http://purl.uniprot.org/uniprot/G1QPD2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane magnesium transporter (TC 1.A.67) family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport. http://togogenome.org/gene/61853:NIM1K ^@ http://purl.uniprot.org/uniprot/G1RHG5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:IL22 ^@ http://purl.uniprot.org/uniprot/G1QTK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Secreted http://togogenome.org/gene/61853:TIMM8A ^@ http://purl.uniprot.org/uniprot/G1R7I5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/61853:CCNT1 ^@ http://purl.uniprot.org/uniprot/G1S877 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/61853:SERINC2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HTQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/61853:GSX1 ^@ http://purl.uniprot.org/uniprot/G1QHN9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:LOC100596198 ^@ http://purl.uniprot.org/uniprot/A0A2I3HPE7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/61853:PSMA8 ^@ http://purl.uniprot.org/uniprot/G1R452 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/61853:STC2 ^@ http://purl.uniprot.org/uniprot/G1QI14 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/61853:GPN2 ^@ http://purl.uniprot.org/uniprot/G1RDX4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/61853:DERL3 ^@ http://purl.uniprot.org/uniprot/G1QIB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/61853:VAMP5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GN55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/61853:BCL2A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GQS0 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/61853:APH1B ^@ http://purl.uniprot.org/uniprot/G1RNR0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. http://togogenome.org/gene/61853:GALNT13 ^@ http://purl.uniprot.org/uniprot/A0A2I3HN56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:CD55 ^@ http://purl.uniprot.org/uniprot/A0A2I3H2K1|||http://purl.uniprot.org/uniprot/A0A2I3H749|||http://purl.uniprot.org/uniprot/G1QJZ5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:CHAC2 ^@ http://purl.uniprot.org/uniprot/G1RC96 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/61853:UNC50 ^@ http://purl.uniprot.org/uniprot/G1QNC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-50 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/61853:GAS8 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBP2|||http://purl.uniprot.org/uniprot/A0A2I3HZ95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC4 family.|||flagellum|||flagellum axoneme http://togogenome.org/gene/61853:KCND2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GR32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.|||Cell junction|||Cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||dendrite|||dendritic spine http://togogenome.org/gene/61853:GLYCTK ^@ http://purl.uniprot.org/uniprot/G1R637 ^@ Similarity ^@ Belongs to the glycerate kinase type-2 family. http://togogenome.org/gene/61853:MRPS30 ^@ http://purl.uniprot.org/uniprot/A0A2I3GMS3 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/61853:UBE2D1 ^@ http://purl.uniprot.org/uniprot/G1RNY3 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/61853:MINDY2 ^@ http://purl.uniprot.org/uniprot/G1RKZ4 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM63 subfamily.|||Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. http://togogenome.org/gene/61853:MRPL1 ^@ http://purl.uniprot.org/uniprot/G1R9X5 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/61853:SLF2 ^@ http://purl.uniprot.org/uniprot/G1RXM1 ^@ Similarity ^@ Belongs to the FAM178 family. http://togogenome.org/gene/61853:CKMT2 ^@ http://purl.uniprot.org/uniprot/G1RRK3 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/61853:NPY ^@ http://purl.uniprot.org/uniprot/G1RXQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/61853:TM7SF3 ^@ http://purl.uniprot.org/uniprot/G1R044 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:FABP9 ^@ http://purl.uniprot.org/uniprot/G1QPZ3 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/61853:CEP76 ^@ http://purl.uniprot.org/uniprot/G1RCT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP76 family.|||Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.|||centriole http://togogenome.org/gene/61853:MED9 ^@ http://purl.uniprot.org/uniprot/G1RT49 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 9 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/61853:LOC100602087 ^@ http://purl.uniprot.org/uniprot/G1S9V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:TRAPPC3L ^@ http://purl.uniprot.org/uniprot/G1RRP3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/61853:CLCF1 ^@ http://purl.uniprot.org/uniprot/G1R3E8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/61853:DPPA2 ^@ http://purl.uniprot.org/uniprot/G1QV94 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:LOC100598804 ^@ http://purl.uniprot.org/uniprot/G1R7V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/61853:SOST ^@ http://purl.uniprot.org/uniprot/G1R143 ^@ Similarity ^@ Belongs to the sclerostin family. http://togogenome.org/gene/61853:YEATS4 ^@ http://purl.uniprot.org/uniprot/A0A2I3G9K1|||http://purl.uniprot.org/uniprot/G1QUL7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:UXT ^@ http://purl.uniprot.org/uniprot/A0A2I3G2N3 ^@ Similarity ^@ Belongs to the UXT family. http://togogenome.org/gene/61853:SFN ^@ http://purl.uniprot.org/uniprot/G1SAD1 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/61853:GALR1 ^@ http://purl.uniprot.org/uniprot/G1RDS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/61853:PTPN18 ^@ http://purl.uniprot.org/uniprot/G1RID2 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. http://togogenome.org/gene/61853:LOC100581795 ^@ http://purl.uniprot.org/uniprot/A0A2I3H1D0 ^@ Similarity ^@ Belongs to the ficolin lectin family. http://togogenome.org/gene/61853:LOC100587000 ^@ http://purl.uniprot.org/uniprot/A0A2I3HH82 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:ASB1 ^@ http://purl.uniprot.org/uniprot/G1RKM3 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/61853:ABCD2 ^@ http://purl.uniprot.org/uniprot/G1S8I1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:RNF146 ^@ http://purl.uniprot.org/uniprot/G1RV88 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation.|||E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.|||The WWE domain mediates non-covalent poly(ADP-ribose)-binding.|||Ubiquitinated; autoubiquitinated.|||cytosol http://togogenome.org/gene/61853:COG1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GL12 ^@ Similarity ^@ Belongs to the COG1 family. http://togogenome.org/gene/61853:FGF9 ^@ http://purl.uniprot.org/uniprot/G1RSA3 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/61853:GFRA4 ^@ http://purl.uniprot.org/uniprot/G1R7U5 ^@ Similarity ^@ Belongs to the GDNFR family. http://togogenome.org/gene/61853:ABI1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H2B2|||http://purl.uniprot.org/uniprot/A0A2I3H962|||http://purl.uniprot.org/uniprot/A0A2I3HGF8|||http://purl.uniprot.org/uniprot/A0A2I3HWN0|||http://purl.uniprot.org/uniprot/A0A2I3HXX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/61853:NME4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GGB5|||http://purl.uniprot.org/uniprot/G1R9G2 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/61853:CENPL ^@ http://purl.uniprot.org/uniprot/A0A2I3HFI8|||http://purl.uniprot.org/uniprot/G1RZ97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-L/IML3 family.|||Nucleus http://togogenome.org/gene/61853:TMC7 ^@ http://purl.uniprot.org/uniprot/G1R061 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/61853:LOC100585215 ^@ http://purl.uniprot.org/uniprot/G1RHY2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/61853:TCTN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H3P3 ^@ Similarity|||Subunit ^@ Belongs to the tectonic family.|||Part of the tectonic-like complex (also named B9 complex). http://togogenome.org/gene/61853:NAAA ^@ http://purl.uniprot.org/uniprot/G1R9A9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acid ceramidase family.|||Heterodimer.|||Lysosome http://togogenome.org/gene/61853:PEX19 ^@ http://purl.uniprot.org/uniprot/G1RTA6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxin-19 family.|||Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.|||Membrane|||Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.|||Peroxisome membrane http://togogenome.org/gene/61853:BORA ^@ http://purl.uniprot.org/uniprot/A0A2I3HK76|||http://purl.uniprot.org/uniprot/G1S1R4 ^@ Similarity ^@ Belongs to the BORA family. http://togogenome.org/gene/61853:LOC100598362 ^@ http://purl.uniprot.org/uniprot/A0A2I3G4V4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:LOC100607821 ^@ http://purl.uniprot.org/uniprot/A0A2I3GP74|||http://purl.uniprot.org/uniprot/G1RE81|||http://purl.uniprot.org/uniprot/G1SA16|||http://purl.uniprot.org/uniprot/G1SA17|||http://purl.uniprot.org/uniprot/G1SA18 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/61853:TSHB ^@ http://purl.uniprot.org/uniprot/G1QYI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/61853:LTA ^@ http://purl.uniprot.org/uniprot/G1R2J1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.|||Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.|||Membrane|||Secreted http://togogenome.org/gene/61853:HNRNPK ^@ http://purl.uniprot.org/uniprot/G1QTU8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||nucleoplasm|||podosome http://togogenome.org/gene/61853:CD28 ^@ http://purl.uniprot.org/uniprot/A0A2I3HMY4|||http://purl.uniprot.org/uniprot/G1R5X7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:TSPAN2 ^@ http://purl.uniprot.org/uniprot/G1QYJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/61853:PYCR2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G384|||http://purl.uniprot.org/uniprot/G1RTY9 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/61853:LLPH ^@ http://purl.uniprot.org/uniprot/A0A2I3HI64 ^@ Similarity ^@ Belongs to the learning-associated protein family. http://togogenome.org/gene/61853:PHTF2 ^@ http://purl.uniprot.org/uniprot/G1REN2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:RAPSN ^@ http://purl.uniprot.org/uniprot/A0A2I3H3E3|||http://purl.uniprot.org/uniprot/G1RX20 ^@ Similarity ^@ Belongs to the RAPsyn family. http://togogenome.org/gene/61853:TMOD3 ^@ http://purl.uniprot.org/uniprot/G1R3U4 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/61853:CCBE1 ^@ http://purl.uniprot.org/uniprot/G1RAP7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:PIK3CG ^@ http://purl.uniprot.org/uniprot/G1RC26 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/61853:THYN1 ^@ http://purl.uniprot.org/uniprot/G1RPM0 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. http://togogenome.org/gene/61853:RTN2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HPS3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:ANXA4 ^@ http://purl.uniprot.org/uniprot/G1RGJ9 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Zymogen granule membrane http://togogenome.org/gene/61853:ANXA6 ^@ http://purl.uniprot.org/uniprot/A0A2I3H0D8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.|||Melanosome http://togogenome.org/gene/61853:DBNL ^@ http://purl.uniprot.org/uniprot/A0A2I3HIT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABP1 family.|||Early endosome|||Golgi apparatus membrane|||Perikaryon|||Postsynaptic density|||cell cortex|||clathrin-coated vesicle membrane|||dendrite|||lamellipodium|||neuron projection|||podosome|||ruffle http://togogenome.org/gene/61853:ISCA2 ^@ http://purl.uniprot.org/uniprot/G1S2J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/61853:ERG28 ^@ http://purl.uniprot.org/uniprot/G1S3F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG28 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:EIF3G ^@ http://purl.uniprot.org/uniprot/G1RN66 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit G family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation.|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.|||perinuclear region http://togogenome.org/gene/61853:IL17A ^@ http://purl.uniprot.org/uniprot/G1QUS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/61853:DUSP6 ^@ http://purl.uniprot.org/uniprot/A0A2I3HLJ1 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/61853:FAM114A2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GJY3 ^@ Similarity ^@ Belongs to the FAM114 family. http://togogenome.org/gene/61853:TIMP2 ^@ http://purl.uniprot.org/uniprot/G1QGX5 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/61853:PPP1R10 ^@ http://purl.uniprot.org/uniprot/G1QZD7 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers. http://togogenome.org/gene/61853:TOP3A ^@ http://purl.uniprot.org/uniprot/A0A2I3GKX0 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/61853:LOC100604697 ^@ http://purl.uniprot.org/uniprot/G1QX67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/61853:MAGOHB ^@ http://purl.uniprot.org/uniprot/G1QT10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/61853:LOC101179576 ^@ http://purl.uniprot.org/uniprot/A0A2I3GVV1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/61853:COG6 ^@ http://purl.uniprot.org/uniprot/A0A2I3HR50 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COG6 family.|||Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.|||Golgi apparatus membrane|||Membrane|||Required for normal Golgi function. http://togogenome.org/gene/61853:CIAPIN1 ^@ http://purl.uniprot.org/uniprot/G1QRU1 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion intermembrane space|||Monomer. Interacts with NDOR1. Interacts with CHCHD4.|||Nucleus|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/61853:RRAGD ^@ http://purl.uniprot.org/uniprot/G1RRV0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/61853:FTL ^@ http://purl.uniprot.org/uniprot/G1QXR8 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/61853:DSC1 ^@ http://purl.uniprot.org/uniprot/G1R400 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/61853:EXOSC2 ^@ http://purl.uniprot.org/uniprot/G1RPS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP4 family.|||Cytoplasm http://togogenome.org/gene/61853:SPACA4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HX42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPACA4/bouncer family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:HTR1B ^@ http://purl.uniprot.org/uniprot/G1S9T8 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.|||Homodimer. Heterodimer with HTR1D.|||Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.|||Membrane|||Palmitoylated.|||Phosphorylated. http://togogenome.org/gene/61853:MEA1 ^@ http://purl.uniprot.org/uniprot/G1QWX5 ^@ Function ^@ May play an important role in spermatogenesis and/or testis development. http://togogenome.org/gene/61853:EFNA5 ^@ http://purl.uniprot.org/uniprot/G1RK43 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:MCM10 ^@ http://purl.uniprot.org/uniprot/G1RNT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM10 family.|||Nucleus http://togogenome.org/gene/61853:CA1 ^@ http://purl.uniprot.org/uniprot/G1QRE6 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/61853:FBLL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HLU0 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Fibrillarin family. http://togogenome.org/gene/61853:CLCA1 ^@ http://purl.uniprot.org/uniprot/G1RGM8 ^@ Similarity ^@ Belongs to the CLCR family. http://togogenome.org/gene/61853:MRFAP1L1 ^@ http://purl.uniprot.org/uniprot/G1RM76 ^@ Similarity ^@ Belongs to the MORF4 family-associated protein family. http://togogenome.org/gene/61853:LOC100583044 ^@ http://purl.uniprot.org/uniprot/G1SAM4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:ASPHD2 ^@ http://purl.uniprot.org/uniprot/G1R867 ^@ Similarity ^@ Belongs to the aspartyl/asparaginyl beta-hydroxylase family. http://togogenome.org/gene/61853:TPMT ^@ http://purl.uniprot.org/uniprot/A0A2I3HBX2 ^@ Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.|||Monomer. http://togogenome.org/gene/61853:CLDN12 ^@ http://purl.uniprot.org/uniprot/G1RYU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Membrane|||tight junction http://togogenome.org/gene/61853:ASIC4 ^@ http://purl.uniprot.org/uniprot/G1REC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/61853:SLC39A14 ^@ http://purl.uniprot.org/uniprot/A0A2I3GVX1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:ASB17 ^@ http://purl.uniprot.org/uniprot/G1RER4 ^@ Function|||Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family.|||May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/61853:TGFB2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GW08|||http://purl.uniprot.org/uniprot/G1RVC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.|||extracellular matrix http://togogenome.org/gene/61853:ISL1 ^@ http://purl.uniprot.org/uniprot/G1RIK5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:TIPARP ^@ http://purl.uniprot.org/uniprot/G1QV49 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/61853:PIH1D2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G345 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/61853:IL9 ^@ http://purl.uniprot.org/uniprot/G1RA44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-7/IL-9 family.|||Secreted http://togogenome.org/gene/61853:PDK3 ^@ http://purl.uniprot.org/uniprot/G1RGB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/61853:SYBU ^@ http://purl.uniprot.org/uniprot/G1QX08 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:MFSD14A ^@ http://purl.uniprot.org/uniprot/A0A2I3GNP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/61853:PGAP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HF16 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI inositol-deacylase family.|||Endoplasmic reticulum membrane|||Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.|||Membrane http://togogenome.org/gene/61853:HTRA4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HVB1 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/61853:LOC100582195 ^@ http://purl.uniprot.org/uniprot/A0A1K0H3N2 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/61853:SOD3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GYD9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/61853:CLDN18 ^@ http://purl.uniprot.org/uniprot/A0A2I3FWW8|||http://purl.uniprot.org/uniprot/A0A2I3GFX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/61853:ACAD11 ^@ http://purl.uniprot.org/uniprot/G1QSQ8 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/61853:PSME1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GLV9 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/61853:MDM2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G0V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Cytoplasm|||nucleolus|||nucleoplasm http://togogenome.org/gene/61853:IFNA6 ^@ http://purl.uniprot.org/uniprot/A0A7R8C319 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/61853:ELMO2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GSJ0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/61853:LOC100587683 ^@ http://purl.uniprot.org/uniprot/A0A2I3HHC8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family. http://togogenome.org/gene/61853:NT5DC3 ^@ http://purl.uniprot.org/uniprot/G1R3Y8 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/61853:EPB42 ^@ http://purl.uniprot.org/uniprot/A0A2I3GFA9|||http://purl.uniprot.org/uniprot/G1QY95 ^@ Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family. http://togogenome.org/gene/61853:CA11 ^@ http://purl.uniprot.org/uniprot/G1QX88 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Does not have a catalytic activity. http://togogenome.org/gene/61853:SPC25 ^@ http://purl.uniprot.org/uniprot/G1QXH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC25 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/61853:RAB32 ^@ http://purl.uniprot.org/uniprot/A0A2I3H8M2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/61853:AASDH ^@ http://purl.uniprot.org/uniprot/G1RBT3 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/61853:E2F5 ^@ http://purl.uniprot.org/uniprot/G1QR80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/61853:TMEM184B ^@ http://purl.uniprot.org/uniprot/G1RYJ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:TFAP2B ^@ http://purl.uniprot.org/uniprot/G1QV41 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/61853:LSM14A ^@ http://purl.uniprot.org/uniprot/A0A2I3GF12|||http://purl.uniprot.org/uniprot/G1RM06 ^@ Similarity ^@ Belongs to the LSM14 family. http://togogenome.org/gene/61853:TASOR ^@ http://purl.uniprot.org/uniprot/A0A2I3FZV1|||http://purl.uniprot.org/uniprot/G1R6L5 ^@ Similarity ^@ Belongs to the TASOR family. http://togogenome.org/gene/61853:C2H5orf24 ^@ http://purl.uniprot.org/uniprot/G1R9T0 ^@ Similarity ^@ Belongs to the UPF0461 family. http://togogenome.org/gene/61853:SLC13A4 ^@ http://purl.uniprot.org/uniprot/G1RT98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/61853:SRPRA ^@ http://purl.uniprot.org/uniprot/A0A2I3GK36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:LOC100594586 ^@ http://purl.uniprot.org/uniprot/G1S9R7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:SERINC1 ^@ http://purl.uniprot.org/uniprot/M3ZAQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/61853:SLC10A6 ^@ http://purl.uniprot.org/uniprot/G1RE13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/61853:TIMM9 ^@ http://purl.uniprot.org/uniprot/A0A2I3H2L7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/61853:LOC100600563 ^@ http://purl.uniprot.org/uniprot/A0A2I3G2E1|||http://purl.uniprot.org/uniprot/G1RDM6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/61853:SNX17 ^@ http://purl.uniprot.org/uniprot/G1QTR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/61853:RPL3L ^@ http://purl.uniprot.org/uniprot/G1RC55 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/61853:MTRF1L ^@ http://purl.uniprot.org/uniprot/G1RZT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/61853:TARS2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GTP4|||http://purl.uniprot.org/uniprot/G1RFM9 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/61853:MAT2B ^@ http://purl.uniprot.org/uniprot/A0A2I3GF32|||http://purl.uniprot.org/uniprot/G1QY02 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.|||Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.|||Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. http://togogenome.org/gene/61853:SLC39A5 ^@ http://purl.uniprot.org/uniprot/G1S6Y5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:PIK3C2G ^@ http://purl.uniprot.org/uniprot/A0A2I3GHE4|||http://purl.uniprot.org/uniprot/G1QWK3 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/61853:SUMF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GYN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase-modifying factor family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/61853:MMP25 ^@ http://purl.uniprot.org/uniprot/G1REM2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/61853:ARFGEF1 ^@ http://purl.uniprot.org/uniprot/G1RJN8 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||perinuclear region http://togogenome.org/gene/61853:ADD2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GJ27 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/61853:TMEM106B ^@ http://purl.uniprot.org/uniprot/G1S2E2 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/61853:IDH2 ^@ http://purl.uniprot.org/uniprot/G1RMM2 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Homodimer. http://togogenome.org/gene/61853:CRYGS ^@ http://purl.uniprot.org/uniprot/G1R449 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/61853:LOC100583780 ^@ http://purl.uniprot.org/uniprot/G1SBU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:CD40LG ^@ http://purl.uniprot.org/uniprot/A0A2I3HMH8|||http://purl.uniprot.org/uniprot/G1QR70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.|||Belongs to the tumor necrosis factor family.|||Cell surface|||Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.|||Homotrimer. http://togogenome.org/gene/61853:ARF6 ^@ http://purl.uniprot.org/uniprot/A0A2I3GLJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Cell membrane|||Cleavage furrow|||Endosome membrane|||Midbody ring|||Recycling endosome membrane|||filopodium membrane|||ruffle http://togogenome.org/gene/61853:PREB ^@ http://purl.uniprot.org/uniprot/G1QRQ8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat SEC12 family.|||Endoplasmic reticulum membrane|||Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.|||Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. http://togogenome.org/gene/61853:RUNDC3B ^@ http://purl.uniprot.org/uniprot/A0A2I3H1X3|||http://purl.uniprot.org/uniprot/A0A2I3HRX4|||http://purl.uniprot.org/uniprot/G1RYB7 ^@ Similarity|||Subunit ^@ Belongs to the RUNDC3 family.|||Interacts with RAP2A. http://togogenome.org/gene/61853:TMEM38A ^@ http://purl.uniprot.org/uniprot/G1R0N0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/61853:NDUFA12 ^@ http://purl.uniprot.org/uniprot/G1R1B4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA12 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:PTX3 ^@ http://purl.uniprot.org/uniprot/G1QVJ1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:NDRG2 ^@ http://purl.uniprot.org/uniprot/A0A2I3H9Z2|||http://purl.uniprot.org/uniprot/G1RVQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDRG family.|||Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.|||Cytoplasm http://togogenome.org/gene/61853:RGS2 ^@ http://purl.uniprot.org/uniprot/G1S8T4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||nucleolus http://togogenome.org/gene/61853:GREM2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HLU6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:KCNC4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBF6|||http://purl.uniprot.org/uniprot/G1QTR9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:NMI ^@ http://purl.uniprot.org/uniprot/G1RJ51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NMI family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/61853:MCRIP2 ^@ http://purl.uniprot.org/uniprot/G1R9K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCRIP family.|||Nucleus|||Stress granule http://togogenome.org/gene/61853:FOXA3 ^@ http://purl.uniprot.org/uniprot/G1QPL9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:LOC100595338 ^@ http://purl.uniprot.org/uniprot/A0A2I3G0J7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/61853:PDE1A ^@ http://purl.uniprot.org/uniprot/A0A2I3G921 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/61853:LOC100601688 ^@ http://purl.uniprot.org/uniprot/G1RIN9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:LOC100601301 ^@ http://purl.uniprot.org/uniprot/A0A2I3GDY1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/61853:LOC100594235 ^@ http://purl.uniprot.org/uniprot/G1S045 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/61853:LOC100585893 ^@ http://purl.uniprot.org/uniprot/G1QKL1 ^@ Similarity ^@ Belongs to the NUT family. http://togogenome.org/gene/61853:VCX3A ^@ http://purl.uniprot.org/uniprot/A0A2I3HCX0 ^@ Function|||Similarity ^@ Belongs to the VCX/VCY family.|||May mediate a process in spermatogenesis or may play a role in sex ratio distortion. http://togogenome.org/gene/61853:GPR157 ^@ http://purl.uniprot.org/uniprot/G1RDI8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:BAZ2A ^@ http://purl.uniprot.org/uniprot/A0A2I3G1T6 ^@ Similarity ^@ Belongs to the WAL family. http://togogenome.org/gene/61853:KCNS1 ^@ http://purl.uniprot.org/uniprot/G1R4K5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:PLN ^@ http://purl.uniprot.org/uniprot/A0A2I3GAU4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phospholamban family.|||Endoplasmic reticulum membrane|||Homopentamer.|||Membrane|||Mitochondrion membrane|||Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/61853:CCDC43 ^@ http://purl.uniprot.org/uniprot/G1QZI1 ^@ Similarity ^@ Belongs to the CCDC43 family. http://togogenome.org/gene/61853:PRDM5 ^@ http://purl.uniprot.org/uniprot/A0A2I3HCG9|||http://purl.uniprot.org/uniprot/A0A2I3HGA7|||http://purl.uniprot.org/uniprot/G1RD15 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:HEATR5B ^@ http://purl.uniprot.org/uniprot/G1S295 ^@ Similarity ^@ Belongs to the HEATR5 family. http://togogenome.org/gene/61853:GATAD2B ^@ http://purl.uniprot.org/uniprot/G1RIE3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:NEURL2 ^@ http://purl.uniprot.org/uniprot/G1R4Z8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:NUDT7 ^@ http://purl.uniprot.org/uniprot/A0A2I3HWT9|||http://purl.uniprot.org/uniprot/G1RS58 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. PCD1 subfamily. http://togogenome.org/gene/61853:TNFSF4 ^@ http://purl.uniprot.org/uniprot/G1RZ60 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/61853:LOC100605186 ^@ http://purl.uniprot.org/uniprot/A0A2I3GRT4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).|||Membrane|||Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. http://togogenome.org/gene/61853:EMP1 ^@ http://purl.uniprot.org/uniprot/G1QUA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/61853:NKX2-6 ^@ http://purl.uniprot.org/uniprot/G1S1H0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:SLC35F2 ^@ http://purl.uniprot.org/uniprot/G1R6I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/61853:STX4 ^@ http://purl.uniprot.org/uniprot/G1S1Y7 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/61853:MLF2 ^@ http://purl.uniprot.org/uniprot/G1QXH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLF family.|||Cytoplasm http://togogenome.org/gene/61853:LOC100580355 ^@ http://purl.uniprot.org/uniprot/G1RGY1 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/61853:VCAN ^@ http://purl.uniprot.org/uniprot/A0A2I3G769|||http://purl.uniprot.org/uniprot/A0A2I3H1D7|||http://purl.uniprot.org/uniprot/G1RSI0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aggrecan/versican proteoglycan family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/61853:LITAF ^@ http://purl.uniprot.org/uniprot/A0A2I3H1A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/61853:EEF1AKMT1 ^@ http://purl.uniprot.org/uniprot/G1QMJ6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.|||Cytoplasm|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.|||Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure. http://togogenome.org/gene/61853:SLCO5A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HN32|||http://purl.uniprot.org/uniprot/G1RKH9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:PNLDC1 ^@ http://purl.uniprot.org/uniprot/G1RKI3 ^@ Similarity ^@ Belongs to the CAF1 family. http://togogenome.org/gene/61853:CAPN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HW10 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/61853:SNX5 ^@ http://purl.uniprot.org/uniprot/A0A2I3H5G5 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/61853:CMTM5 ^@ http://purl.uniprot.org/uniprot/G1RYF3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:SLC13A2 ^@ http://purl.uniprot.org/uniprot/G1QP88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/61853:RPL36AL ^@ http://purl.uniprot.org/uniprot/G1SBY5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/61853:METAP1 ^@ http://purl.uniprot.org/uniprot/G1RUR4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/61853:SND1 ^@ http://purl.uniprot.org/uniprot/G1RNW5 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. http://togogenome.org/gene/61853:LOC100594276 ^@ http://purl.uniprot.org/uniprot/A0A2I3H5M9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:ALDH5A1 ^@ http://purl.uniprot.org/uniprot/G1QNY5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aldehyde dehydrogenase family.|||Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).|||Homotetramer.|||Mitochondrion http://togogenome.org/gene/61853:LOC100602030 ^@ http://purl.uniprot.org/uniprot/A0A2I3HVY4 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/61853:UCP2 ^@ http://purl.uniprot.org/uniprot/G1S5F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/61853:LOC100605698 ^@ http://purl.uniprot.org/uniprot/G1QS41 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/61853:NLRP4 ^@ http://purl.uniprot.org/uniprot/G1RIF5 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/61853:FGD1 ^@ http://purl.uniprot.org/uniprot/G1S2D9 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/61853:DDIT4L ^@ http://purl.uniprot.org/uniprot/G1RTG4 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/61853:LOC100587920 ^@ http://purl.uniprot.org/uniprot/G1SC77 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:CDC14A ^@ http://purl.uniprot.org/uniprot/G1RMG1 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. http://togogenome.org/gene/61853:CPSF6 ^@ http://purl.uniprot.org/uniprot/A0A2I3HRI7|||http://purl.uniprot.org/uniprot/G1QUJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM CPSF6/7 family.|||Nucleus http://togogenome.org/gene/61853:LIMS1 ^@ http://purl.uniprot.org/uniprot/G1RJF7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.|||Cell membrane|||Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.|||focal adhesion http://togogenome.org/gene/61853:ZEB1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HC21 ^@ Similarity ^@ Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. http://togogenome.org/gene/61853:SGCZ ^@ http://purl.uniprot.org/uniprot/G1QNQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/61853:ZDHHC2 ^@ http://purl.uniprot.org/uniprot/G1QPY3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/61853:DDC ^@ http://purl.uniprot.org/uniprot/A0A2I3GGH6|||http://purl.uniprot.org/uniprot/A0A2I3GQN2|||http://purl.uniprot.org/uniprot/A0A2I3HF22|||http://purl.uniprot.org/uniprot/A0A2I3HP61|||http://purl.uniprot.org/uniprot/A0A2I3HRT2|||http://purl.uniprot.org/uniprot/G1RA43 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/61853:NOP56 ^@ http://purl.uniprot.org/uniprot/G1RD85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus|||nucleoplasm http://togogenome.org/gene/61853:TBCCD1 ^@ http://purl.uniprot.org/uniprot/G1R453 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCC family.|||centrosome|||spindle pole http://togogenome.org/gene/61853:PDIA3 ^@ http://purl.uniprot.org/uniprot/G1R041 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/61853:ATG13 ^@ http://purl.uniprot.org/uniprot/A0A2I3HDI4|||http://purl.uniprot.org/uniprot/A0A2I3HZW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.|||Belongs to the ATG13 family. Metazoan subfamily.|||Preautophagosomal structure http://togogenome.org/gene/61853:CRYBB1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G937 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/61853:HEATR1 ^@ http://purl.uniprot.org/uniprot/G1QTJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HEATR1/UTP10 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/61853:PRPF4B ^@ http://purl.uniprot.org/uniprot/G1RKL9 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.|||Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF. http://togogenome.org/gene/61853:PPP1R12A ^@ http://purl.uniprot.org/uniprot/A0A2I3GQA8|||http://purl.uniprot.org/uniprot/A0A2I3HX50 ^@ Subcellular Location Annotation|||Subunit ^@ PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.|||stress fiber http://togogenome.org/gene/61853:DPH5 ^@ http://purl.uniprot.org/uniprot/G1RMS0 ^@ Function|||Similarity ^@ Belongs to the diphthine synthase family.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/61853:TCEA1 ^@ http://purl.uniprot.org/uniprot/G1QJV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/61853:TLR4 ^@ http://purl.uniprot.org/uniprot/A0A2I3FXK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/61853:CLEC12A ^@ http://purl.uniprot.org/uniprot/A0A2I3GYK5|||http://purl.uniprot.org/uniprot/A0A2I3HAZ6|||http://purl.uniprot.org/uniprot/G1QS00 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:FBXO32 ^@ http://purl.uniprot.org/uniprot/G1QZV8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:IL2RA ^@ http://purl.uniprot.org/uniprot/A0A2I3GVZ5|||http://purl.uniprot.org/uniprot/G1RLR0 ^@ Caution|||Function|||Subunit ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.|||Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. http://togogenome.org/gene/61853:TAC3 ^@ http://purl.uniprot.org/uniprot/G1S6L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted http://togogenome.org/gene/61853:DNASE1L3 ^@ http://purl.uniprot.org/uniprot/G1R6T4 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/61853:MED23 ^@ http://purl.uniprot.org/uniprot/G1RWE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 23 family.|||Nucleus http://togogenome.org/gene/61853:LSM8 ^@ http://purl.uniprot.org/uniprot/G1RM40 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. http://togogenome.org/gene/61853:FOXO3 ^@ http://purl.uniprot.org/uniprot/G1RPE6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:MMRN1 ^@ http://purl.uniprot.org/uniprot/G1RVZ5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:NDUFV3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GI04|||http://purl.uniprot.org/uniprot/G1RX70 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.|||Belongs to the complex I NDUFV3 subunit family.|||Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. http://togogenome.org/gene/61853:LMOD2 ^@ http://purl.uniprot.org/uniprot/G1RND7 ^@ Subcellular Location Annotation ^@ cytoskeleton|||sarcomere http://togogenome.org/gene/61853:LOC100601648 ^@ http://purl.uniprot.org/uniprot/A0A2I3GZ19 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/61853:CWC15 ^@ http://purl.uniprot.org/uniprot/A0A2I3HUF5 ^@ Similarity ^@ Belongs to the CWC15 family. http://togogenome.org/gene/61853:ARL4D ^@ http://purl.uniprot.org/uniprot/A0A2I3HI15 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/61853:DIPK2B ^@ http://purl.uniprot.org/uniprot/A0A2I3FYG9|||http://purl.uniprot.org/uniprot/A0A2I3GC66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/61853:CACYBP ^@ http://purl.uniprot.org/uniprot/G1RZI0 ^@ Function ^@ May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). http://togogenome.org/gene/61853:ISY1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GVL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ISY1 family.|||Nucleus http://togogenome.org/gene/61853:SULT2B1 ^@ http://purl.uniprot.org/uniprot/G1QX14 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/61853:GNAT3 ^@ http://purl.uniprot.org/uniprot/G1RX93 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/61853:ST6GAL1 ^@ http://purl.uniprot.org/uniprot/G1R4K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/61853:ATAD2B ^@ http://purl.uniprot.org/uniprot/G1QIW9 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/61853:SEPHS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HGA9 ^@ Function ^@ Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/61853:LOC100582711 ^@ http://purl.uniprot.org/uniprot/H9HA59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:MMP20 ^@ http://purl.uniprot.org/uniprot/G1R6B1 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/61853:MS4A4A ^@ http://purl.uniprot.org/uniprot/A0A2I3HN35|||http://purl.uniprot.org/uniprot/G1RSG5 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/61853:TFPI2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GRA7 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/61853:INPP4A ^@ http://purl.uniprot.org/uniprot/A0A2I3GSY8|||http://purl.uniprot.org/uniprot/A0A2I3H1M3|||http://purl.uniprot.org/uniprot/A0A2I3H4A0 ^@ Similarity ^@ Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. http://togogenome.org/gene/61853:LOC100581858 ^@ http://purl.uniprot.org/uniprot/G1S9A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/61853:LOC100590351 ^@ http://purl.uniprot.org/uniprot/G1SCC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:LOC100607640 ^@ http://purl.uniprot.org/uniprot/G1RHT3 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/61853:CDH6 ^@ http://purl.uniprot.org/uniprot/G1RUL4 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:FAM98B ^@ http://purl.uniprot.org/uniprot/A0A2I3GIR7 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/61853:GRM5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GJL1|||http://purl.uniprot.org/uniprot/G1S1X6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:RPL30 ^@ http://purl.uniprot.org/uniprot/A0A2I3G660 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/61853:SLC16A3 ^@ http://purl.uniprot.org/uniprot/G1RV25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/61853:LSM7 ^@ http://purl.uniprot.org/uniprot/G1QP48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/61853:PPBP ^@ http://purl.uniprot.org/uniprot/G1R8X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/61853:HENMT1 ^@ http://purl.uniprot.org/uniprot/G1QLX1 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. HEN1 family. http://togogenome.org/gene/61853:PADI4 ^@ http://purl.uniprot.org/uniprot/G1R8C5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/61853:NDUFB2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GQL0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:MTAP ^@ http://purl.uniprot.org/uniprot/A0A2I3GRK1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Cytoplasm|||Homotrimer.|||Nucleus http://togogenome.org/gene/61853:SLC35B2 ^@ http://purl.uniprot.org/uniprot/G1QU44|||http://purl.uniprot.org/uniprot/M3ZAM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/61853:C8A ^@ http://purl.uniprot.org/uniprot/G1RXC0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/61853:FAH ^@ http://purl.uniprot.org/uniprot/G1RCF9 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/61853:CMPK1 ^@ http://purl.uniprot.org/uniprot/G1S2X9 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.|||Binds 1 Mg(2+) ion per monomer.|||Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/61853:FUT9 ^@ http://purl.uniprot.org/uniprot/A0A2I3HAE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/61853:SBK1 ^@ http://purl.uniprot.org/uniprot/G1RL98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.|||Cytoplasm http://togogenome.org/gene/61853:ARF1 ^@ http://purl.uniprot.org/uniprot/G1RVH9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/61853:TMEM177 ^@ http://purl.uniprot.org/uniprot/A0A2I3HIU8 ^@ Function|||Similarity ^@ Belongs to the TMEM177 family.|||Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein. http://togogenome.org/gene/61853:SLC20A1 ^@ http://purl.uniprot.org/uniprot/G1QMJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/61853:ZMPSTE24 ^@ http://purl.uniprot.org/uniprot/A0A2I3I081 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48A family.|||Binds 1 zinc ion per subunit.|||Endoplasmic reticulum membrane|||Proteolytically removes the C-terminal three residues of farnesylated proteins. http://togogenome.org/gene/61853:SLC25A46 ^@ http://purl.uniprot.org/uniprot/A0A2I3G9P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/61853:OGFOD1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GZI4 ^@ Similarity ^@ Belongs to the TPA1 family. http://togogenome.org/gene/61853:CYFIP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GCB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYFIP family.|||synaptosome http://togogenome.org/gene/61853:LOC100594622 ^@ http://purl.uniprot.org/uniprot/G1S5V0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/61853:TSSK2 ^@ http://purl.uniprot.org/uniprot/G1SC02 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:STAT2 ^@ http://purl.uniprot.org/uniprot/G1S6V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:CTSZ ^@ http://purl.uniprot.org/uniprot/G1REJ2 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/61853:ADH1B ^@ http://purl.uniprot.org/uniprot/A0A2I3HZ96 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/61853:C5 ^@ http://purl.uniprot.org/uniprot/G1S5G0 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/61853:VNN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HJ48 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/61853:C15H11orf87 ^@ http://purl.uniprot.org/uniprot/A0A2I3HM21 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:NGB ^@ http://purl.uniprot.org/uniprot/G1S403 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/61853:LEF1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GUR9|||http://purl.uniprot.org/uniprot/A0A2I3H062|||http://purl.uniprot.org/uniprot/A0A2I3HVW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/61853:DLAT ^@ http://purl.uniprot.org/uniprot/G1R6S0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 2 lipoyl cofactors covalently.|||Mitochondrion matrix|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/61853:ARPC5L ^@ http://purl.uniprot.org/uniprot/G1S679 ^@ Function|||Similarity ^@ Belongs to the ARPC5 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. http://togogenome.org/gene/61853:SH3BGRL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HKF9 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/61853:NLRP12 ^@ http://purl.uniprot.org/uniprot/A0A2I3HZ34|||http://purl.uniprot.org/uniprot/G1R2T8 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/61853:TRAM2 ^@ http://purl.uniprot.org/uniprot/G1QUA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/61853:HPSE2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HML9|||http://purl.uniprot.org/uniprot/G1RWP8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/61853:SLC10A3 ^@ http://purl.uniprot.org/uniprot/G1RVS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/61853:STEAP1 ^@ http://purl.uniprot.org/uniprot/G1RYP5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:ASB11 ^@ http://purl.uniprot.org/uniprot/A0A2I3HG12|||http://purl.uniprot.org/uniprot/G1RDS7 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/61853:SLC16A7 ^@ http://purl.uniprot.org/uniprot/G1S5M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/61853:IL16 ^@ http://purl.uniprot.org/uniprot/G1QL12 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Homotetramer.|||Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.|||Nucleus|||Secreted http://togogenome.org/gene/61853:LRRC8C ^@ http://purl.uniprot.org/uniprot/A0A2I3HQM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:S100A6 ^@ http://purl.uniprot.org/uniprot/G1RHF5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.|||Nucleus envelope http://togogenome.org/gene/61853:LOC100606648 ^@ http://purl.uniprot.org/uniprot/A0A2I3GJ91 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/61853:NIP7 ^@ http://purl.uniprot.org/uniprot/G1R0C8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NIP7 family.|||Interacts with pre-ribosome complex.|||Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.|||nucleolus http://togogenome.org/gene/61853:IFT46 ^@ http://purl.uniprot.org/uniprot/A0A2I3GX77|||http://purl.uniprot.org/uniprot/G1R716 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT46 family.|||cilium|||cilium basal body http://togogenome.org/gene/61853:FOXO1 ^@ http://purl.uniprot.org/uniprot/G1QKB1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/61853:RAMP3 ^@ http://purl.uniprot.org/uniprot/G1QVT5 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/61853:CAT ^@ http://purl.uniprot.org/uniprot/G1S8D5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the catalase family.|||Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.|||Peroxisome http://togogenome.org/gene/61853:TMED6 ^@ http://purl.uniprot.org/uniprot/G1R0D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:CACNG5 ^@ http://purl.uniprot.org/uniprot/G1QHB8 ^@ Similarity ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. http://togogenome.org/gene/61853:TCIRG1 ^@ http://purl.uniprot.org/uniprot/G1R426 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/61853:DPP3 ^@ http://purl.uniprot.org/uniprot/G1R2N9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M49 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/61853:CD14 ^@ http://purl.uniprot.org/uniprot/G1RDN0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPAR1.|||Cell membrane|||Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).|||Golgi apparatus|||Membrane raft|||Secreted http://togogenome.org/gene/61853:NCR3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GFC8|||http://purl.uniprot.org/uniprot/G1R2M3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the natural cytotoxicity receptor (NCR) family.|||Cell membrane|||Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.|||Membrane http://togogenome.org/gene/61853:BARHL1 ^@ http://purl.uniprot.org/uniprot/G1RQV8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:PNPLA4 ^@ http://purl.uniprot.org/uniprot/G1RBC3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:NKD1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H1C5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NKD family.|||Cell autonomous antagonist of the canonical Wnt signaling pathway.|||Cell membrane|||Cytoplasm http://togogenome.org/gene/61853:IFNAR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HAU8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II cytokine receptor family.|||Cell membrane|||Endosome|||Heterodimer with IFNAR2.|||Late endosome|||Lysosome|||Membrane|||Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. http://togogenome.org/gene/61853:NKX6-1 ^@ http://purl.uniprot.org/uniprot/G1RD47 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:ROM1 ^@ http://purl.uniprot.org/uniprot/G1QV04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/61853:RPS26 ^@ http://purl.uniprot.org/uniprot/M3ZC70 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/61853:FZD9 ^@ http://purl.uniprot.org/uniprot/G1SAN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:SNX20 ^@ http://purl.uniprot.org/uniprot/A0A2I3H4E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Membrane http://togogenome.org/gene/61853:SNRPB ^@ http://purl.uniprot.org/uniprot/A0A2I3H907 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP SmB/SmN family.|||Nucleus http://togogenome.org/gene/61853:RPIA ^@ http://purl.uniprot.org/uniprot/G1QSD6 ^@ Similarity ^@ Belongs to the ribose 5-phosphate isomerase family. http://togogenome.org/gene/61853:CPOX ^@ http://purl.uniprot.org/uniprot/A0A2I3HPL9 ^@ Similarity|||Subunit ^@ Belongs to the aerobic coproporphyrinogen-III oxidase family.|||Homodimer. http://togogenome.org/gene/61853:LYRM9 ^@ http://purl.uniprot.org/uniprot/G1QMF4 ^@ Similarity ^@ Belongs to the complex I LYR family. LYRM9 subfamily. http://togogenome.org/gene/61853:HM13 ^@ http://purl.uniprot.org/uniprot/A0A2I3HP35|||http://purl.uniprot.org/uniprot/G1REQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Membrane http://togogenome.org/gene/61853:NDEL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HQP5|||http://purl.uniprot.org/uniprot/G1RG26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudE family.|||centrosome|||kinetochore|||spindle http://togogenome.org/gene/61853:POLR3C ^@ http://purl.uniprot.org/uniprot/G1R0Y6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/61853:PRMT5 ^@ http://purl.uniprot.org/uniprot/G1RXT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).|||Belongs to the class I-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:NUDT3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HQ60 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/61853:GUCY1A1 ^@ http://purl.uniprot.org/uniprot/G1R2Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/61853:SYT14 ^@ http://purl.uniprot.org/uniprot/A0A2I3FV99|||http://purl.uniprot.org/uniprot/A0A2I3HQW6 ^@ Similarity ^@ Belongs to the synaptotagmin family. http://togogenome.org/gene/61853:LOC100585841 ^@ http://purl.uniprot.org/uniprot/G1S9V0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/61853:PKP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G9V5|||http://purl.uniprot.org/uniprot/G1S8X3 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/61853:ADAM7 ^@ http://purl.uniprot.org/uniprot/A0A2I3HR67 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:ATXN10 ^@ http://purl.uniprot.org/uniprot/G1RTK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ataxin-10 family.|||Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.|||perinuclear region http://togogenome.org/gene/61853:SMG7 ^@ http://purl.uniprot.org/uniprot/G1S8Q3 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays a role in nonsense-mediated mRNA decay. http://togogenome.org/gene/61853:EFEMP1 ^@ http://purl.uniprot.org/uniprot/G1RE04 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:MOSPD1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GEQ7|||http://purl.uniprot.org/uniprot/G1QNS5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:ZNF446 ^@ http://purl.uniprot.org/uniprot/G1RK17 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:ARL14 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBL2 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/61853:GBP4 ^@ http://purl.uniprot.org/uniprot/G1RGY5 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/61853:PTPN2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GGZ2|||http://purl.uniprot.org/uniprot/A0A2I3HME3 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. http://togogenome.org/gene/61853:RBM22 ^@ http://purl.uniprot.org/uniprot/G1RHG3 ^@ Similarity ^@ Belongs to the SLT11 family. http://togogenome.org/gene/61853:BBS2 ^@ http://purl.uniprot.org/uniprot/G1QNZ0 ^@ Subcellular Location Annotation ^@ centriolar satellite|||cilium membrane http://togogenome.org/gene/61853:CNIH1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GQE6|||http://purl.uniprot.org/uniprot/G1RQB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/61853:PTGER4 ^@ http://purl.uniprot.org/uniprot/G1S375 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with FEM1A.|||Membrane|||Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. http://togogenome.org/gene/61853:FARSB ^@ http://purl.uniprot.org/uniprot/A0A2I3GYC0 ^@ Similarity ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. http://togogenome.org/gene/61853:DCT ^@ http://purl.uniprot.org/uniprot/A0A2I3HTD7|||http://purl.uniprot.org/uniprot/G1S3C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/61853:GRM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GBH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:TMEM176B ^@ http://purl.uniprot.org/uniprot/A0A2I3H333|||http://purl.uniprot.org/uniprot/G1QUS6 ^@ Similarity ^@ Belongs to the TMEM176 family. http://togogenome.org/gene/61853:FGF14 ^@ http://purl.uniprot.org/uniprot/G1R8L4 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/61853:PTHLH ^@ http://purl.uniprot.org/uniprot/A0A2I3G0E4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the parathyroid hormone family.|||Cytoplasm|||Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.|||Nucleus|||Osteostatin is a potent inhibitor of osteoclastic bone resorption.|||PTHrP interacts with PTH1R (via N-terminal extracellular domain).|||Secreted|||There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions. http://togogenome.org/gene/61853:ATP5F1C ^@ http://purl.uniprot.org/uniprot/A0A2I3GAS6|||http://purl.uniprot.org/uniprot/G1RMQ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/61853:BRINP3 ^@ http://purl.uniprot.org/uniprot/G1S8S9 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/61853:NEUROD1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HW20 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:CHMP4B ^@ http://purl.uniprot.org/uniprot/G1RG70 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/61853:ALDH8A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H2V2|||http://purl.uniprot.org/uniprot/G1RXB8 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/61853:IFNB1 ^@ http://purl.uniprot.org/uniprot/G1SBE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/61853:NIPAL1 ^@ http://purl.uniprot.org/uniprot/G1S6F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/61853:ALDH4A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3FUQ8 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/61853:FNIP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GXQ5|||http://purl.uniprot.org/uniprot/A0A2I3HT98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNIP family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/61853:CCDC86 ^@ http://purl.uniprot.org/uniprot/G1RT87 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:ACP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GWY7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.|||Belongs to the low molecular weight phosphotyrosine protein phosphatase family.|||Cytoplasm http://togogenome.org/gene/61853:ARSL ^@ http://purl.uniprot.org/uniprot/A0A2I3GNJ5|||http://purl.uniprot.org/uniprot/G1RAW9 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/61853:ISOC1 ^@ http://purl.uniprot.org/uniprot/G1RP92 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/61853:ADGRB3 ^@ http://purl.uniprot.org/uniprot/G1QI60 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:PYM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HHT0|||http://purl.uniprot.org/uniprot/G1S755 ^@ Similarity|||Subunit ^@ Belongs to the pym family.|||Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex. http://togogenome.org/gene/61853:CDC26 ^@ http://purl.uniprot.org/uniprot/G1S3V0 ^@ Function|||Similarity ^@ Belongs to the CDC26 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. http://togogenome.org/gene/61853:TES ^@ http://purl.uniprot.org/uniprot/Q07DY3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prickle / espinas / testin family.|||Cytoplasm|||Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer (By similarity).|||Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity).|||The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.|||focal adhesion http://togogenome.org/gene/61853:KIF16B ^@ http://purl.uniprot.org/uniprot/A0A2I3G9E5|||http://purl.uniprot.org/uniprot/A0A2I3GBA1|||http://purl.uniprot.org/uniprot/A0A2I3HLC8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/61853:STX11 ^@ http://purl.uniprot.org/uniprot/G1RYS7 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/61853:IER3IP1 ^@ http://purl.uniprot.org/uniprot/G1RL16 ^@ Similarity ^@ Belongs to the YOS1 family. http://togogenome.org/gene/61853:NAXE ^@ http://purl.uniprot.org/uniprot/G1RQ60 ^@ Caution|||Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NnrE/AIBP family.|||Binds 1 potassium ion per subunit.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis.|||Homodimer. Interacts with APOA1 and APOA2.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion|||Secreted|||Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation. http://togogenome.org/gene/61853:VGLL4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HND5|||http://purl.uniprot.org/uniprot/G1QX51 ^@ Function|||Similarity ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs. http://togogenome.org/gene/61853:ATP1A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GH95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:FGF19 ^@ http://purl.uniprot.org/uniprot/G1RHK0 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/61853:LOC100593132 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TTC30/dfy-1/fleer family.|||Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.|||cilium http://togogenome.org/gene/61853:CDC42SE2 ^@ http://purl.uniprot.org/uniprot/A0A2I3FV31 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.|||Membrane|||Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.|||cytoskeleton http://togogenome.org/gene/61853:EMC6 ^@ http://purl.uniprot.org/uniprot/G1S617 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC6 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:HMGCR ^@ http://purl.uniprot.org/uniprot/G1QZ41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMG-CoA reductase family.|||Endoplasmic reticulum membrane|||Membrane|||Peroxisome membrane http://togogenome.org/gene/61853:VAX2 ^@ http://purl.uniprot.org/uniprot/G1RGW6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:TPRKB ^@ http://purl.uniprot.org/uniprot/G1QHH7 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/61853:GJB3 ^@ http://purl.uniprot.org/uniprot/A0A654ICW8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/61853:CPLANE2 ^@ http://purl.uniprot.org/uniprot/G1R8H8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.|||cilium basal body http://togogenome.org/gene/61853:INTS12 ^@ http://purl.uniprot.org/uniprot/G1RRS9 ^@ Similarity|||Subunit ^@ Belongs to the Integrator subunit 12 family.|||Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. http://togogenome.org/gene/61853:CASC4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HGM4|||http://purl.uniprot.org/uniprot/G1R0H6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLM family.|||Membrane http://togogenome.org/gene/61853:CCDC39 ^@ http://purl.uniprot.org/uniprot/G1R1U4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC39 family.|||cilium axoneme http://togogenome.org/gene/61853:LOC100603248 ^@ http://purl.uniprot.org/uniprot/G1SCB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:INHBE ^@ http://purl.uniprot.org/uniprot/G1S6B4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/61853:TAF12 ^@ http://purl.uniprot.org/uniprot/G1RFH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF12 family.|||Nucleus http://togogenome.org/gene/61853:LOC100588957 ^@ http://purl.uniprot.org/uniprot/A0A2I3GNK0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 5A family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:LOC100606472 ^@ http://purl.uniprot.org/uniprot/A0A2I3GKB4 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/61853:HAL ^@ http://purl.uniprot.org/uniprot/A0A2I3GI78|||http://purl.uniprot.org/uniprot/G1R1R0 ^@ Similarity ^@ Belongs to the PAL/histidase family. http://togogenome.org/gene/61853:HTR1E ^@ http://purl.uniprot.org/uniprot/G1RQZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:MAPK13 ^@ http://purl.uniprot.org/uniprot/G1RCL2 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Interacts with MAPK8IP2. http://togogenome.org/gene/61853:LGR5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GFU9|||http://purl.uniprot.org/uniprot/A0A2I3GTX0|||http://purl.uniprot.org/uniprot/A0A2I3HQ88 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:GOLT1B ^@ http://purl.uniprot.org/uniprot/A0A2I3GRJ1|||http://purl.uniprot.org/uniprot/G1QY33 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/61853:GAPDH ^@ http://purl.uniprot.org/uniprot/G1QVR0 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/61853:ZDHHC15 ^@ http://purl.uniprot.org/uniprot/A0A2I3G564|||http://purl.uniprot.org/uniprot/G1QK60 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/61853:RBM3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GZU2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:CCR2 ^@ http://purl.uniprot.org/uniprot/G1RS01 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:CNTF ^@ http://purl.uniprot.org/uniprot/A0A2I3FY37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNTF family.|||CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.|||Cytoplasm http://togogenome.org/gene/61853:NR4A2 ^@ http://purl.uniprot.org/uniprot/G1QIL7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family.|||Cytoplasm|||Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.|||Nucleus http://togogenome.org/gene/61853:ACADL ^@ http://purl.uniprot.org/uniprot/G1R6D2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acyl-CoA dehydrogenase family.|||Homotetramer.|||Mitochondrion matrix http://togogenome.org/gene/61853:SNRPC ^@ http://purl.uniprot.org/uniprot/A0A2I3HAU6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U1 small nuclear ribonucleoprotein C family.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Nucleus|||U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. http://togogenome.org/gene/61853:AQP10 ^@ http://purl.uniprot.org/uniprot/G1RKI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/61853:TBC1D23 ^@ http://purl.uniprot.org/uniprot/G1QQF2 ^@ Subcellular Location Annotation ^@ trans-Golgi network http://togogenome.org/gene/61853:LOC100590538 ^@ http://purl.uniprot.org/uniprot/G1S9F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/61853:ABL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GSM6|||http://purl.uniprot.org/uniprot/G1S0A6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/61853:IST1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G144 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IST1 family.|||Cytoplasmic vesicle|||Nucleus envelope http://togogenome.org/gene/61853:MYOZ3 ^@ http://purl.uniprot.org/uniprot/G1RHF2 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/61853:CCT7 ^@ http://purl.uniprot.org/uniprot/G1RHW5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm|||Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. http://togogenome.org/gene/61853:LRP10 ^@ http://purl.uniprot.org/uniprot/G1RXJ8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:MS4A15 ^@ http://purl.uniprot.org/uniprot/A0A2I3HS48|||http://purl.uniprot.org/uniprot/G1RT48 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/61853:PDS5B ^@ http://purl.uniprot.org/uniprot/M3ZBQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDS5 family.|||Nucleus http://togogenome.org/gene/61853:THNSL1 ^@ http://purl.uniprot.org/uniprot/G1S495 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/61853:MAPK1IP1L ^@ http://purl.uniprot.org/uniprot/A0A2I3GI94 ^@ Similarity ^@ Belongs to the MISS family. http://togogenome.org/gene/61853:ANO10 ^@ http://purl.uniprot.org/uniprot/G1R1T1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:CCL28 ^@ http://purl.uniprot.org/uniprot/G1RHI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/61853:FADD ^@ http://purl.uniprot.org/uniprot/G1RHN0 ^@ Function ^@ Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. http://togogenome.org/gene/61853:TMEM230 ^@ http://purl.uniprot.org/uniprot/G1R857 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Early endosome|||Endosome|||Involved in trafficking and recycling of synaptic vesicles.|||Late endosome|||Membrane|||Recycling endosome|||autophagosome|||synaptic vesicle|||trans-Golgi network http://togogenome.org/gene/61853:LOC100596554 ^@ http://purl.uniprot.org/uniprot/G1SAW5 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:NAGPA ^@ http://purl.uniprot.org/uniprot/G1RG36 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:LBX1 ^@ http://purl.uniprot.org/uniprot/G1RXS0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:RTN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GKR8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:GABRG2 ^@ http://purl.uniprot.org/uniprot/A0A2I3H5Q7|||http://purl.uniprot.org/uniprot/G1QXE0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/61853:MUC13 ^@ http://purl.uniprot.org/uniprot/G1QIT6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:PSKH1 ^@ http://purl.uniprot.org/uniprot/G1QYP3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:CCDC47 ^@ http://purl.uniprot.org/uniprot/G1QWF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC47 family.|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/61853:SSTR4 ^@ http://purl.uniprot.org/uniprot/G1SAH0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:KCNJ12 ^@ http://purl.uniprot.org/uniprot/G1RSV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:AMER2 ^@ http://purl.uniprot.org/uniprot/A0A2I3FTN3 ^@ Similarity ^@ Belongs to the Amer family. http://togogenome.org/gene/61853:MTX2 ^@ http://purl.uniprot.org/uniprot/G1R269 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/61853:MCUB ^@ http://purl.uniprot.org/uniprot/G1S3N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCU (TC 1.A.77) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:MRGPRX1 ^@ http://purl.uniprot.org/uniprot/W8W3L7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:MRPL32 ^@ http://purl.uniprot.org/uniprot/A0A2I3GP56 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/61853:SUMO2 ^@ http://purl.uniprot.org/uniprot/A0A2I3H993 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/61853:THOC6 ^@ http://purl.uniprot.org/uniprot/A0A2I3GIG0 ^@ Similarity ^@ Belongs to the WD repeat THOC6 family. http://togogenome.org/gene/61853:LMNB1 ^@ http://purl.uniprot.org/uniprot/G1RNS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||Nucleus lamina http://togogenome.org/gene/61853:PDGFC ^@ http://purl.uniprot.org/uniprot/A0A2I3H9C5 ^@ Caution|||Similarity ^@ Belongs to the PDGF/VEGF growth factor family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:PLP2 ^@ http://purl.uniprot.org/uniprot/H9H9X1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:TMEM14C ^@ http://purl.uniprot.org/uniprot/G1QIE2 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/61853:C8H9orf131 ^@ http://purl.uniprot.org/uniprot/A0A2I3H3V7|||http://purl.uniprot.org/uniprot/A0A2I3H836|||http://purl.uniprot.org/uniprot/G1QXS3 ^@ Similarity ^@ Belongs to the SPATA31 family. http://togogenome.org/gene/61853:EHHADH ^@ http://purl.uniprot.org/uniprot/A0A2I3FVY2|||http://purl.uniprot.org/uniprot/G1R3S4 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/61853:MYD88 ^@ http://purl.uniprot.org/uniprot/A0A2I3HMD5|||http://purl.uniprot.org/uniprot/G1QZU2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.|||Cytoplasm|||Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. http://togogenome.org/gene/61853:SERPIND1 ^@ http://purl.uniprot.org/uniprot/G1QH37 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/61853:ARHGEF6 ^@ http://purl.uniprot.org/uniprot/G1QRL8 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/61853:TMEM132D ^@ http://purl.uniprot.org/uniprot/G1R9V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM132 family.|||Membrane http://togogenome.org/gene/61853:TMEM167A ^@ http://purl.uniprot.org/uniprot/G1RS06 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Membrane http://togogenome.org/gene/61853:NAV3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GLD5 ^@ Similarity ^@ Belongs to the Nav/unc-53 family. http://togogenome.org/gene/61853:ITIH1 ^@ http://purl.uniprot.org/uniprot/G1R6E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/61853:KCNC1 ^@ http://purl.uniprot.org/uniprot/G1S7P7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:MAP1LC3C ^@ http://purl.uniprot.org/uniprot/G1QUJ5 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/61853:ATP1B4 ^@ http://purl.uniprot.org/uniprot/G1RY69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/61853:NUBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HQY7|||http://purl.uniprot.org/uniprot/G1RGK3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Cell projection|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1. http://togogenome.org/gene/61853:FANCM ^@ http://purl.uniprot.org/uniprot/A0A2I3HXM4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. http://togogenome.org/gene/61853:LOC100594969 ^@ http://purl.uniprot.org/uniprot/A0A2I3G2L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase CarF family.|||Membrane http://togogenome.org/gene/61853:CD200R1 ^@ http://purl.uniprot.org/uniprot/G1QWL2 ^@ Similarity ^@ Belongs to the CD200R family. http://togogenome.org/gene/61853:AGBL5 ^@ http://purl.uniprot.org/uniprot/G1QQV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Midbody|||Nucleus|||cytosol|||spindle http://togogenome.org/gene/61853:CBWD1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GAQ4|||http://purl.uniprot.org/uniprot/G1RAL8 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily. http://togogenome.org/gene/61853:FGB ^@ http://purl.uniprot.org/uniprot/G1R2J2 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/61853:CPA2 ^@ http://purl.uniprot.org/uniprot/G1RQH3 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/61853:CRKL ^@ http://purl.uniprot.org/uniprot/G1QGU0 ^@ Similarity ^@ Belongs to the CRK family. http://togogenome.org/gene/61853:TMEM159 ^@ http://purl.uniprot.org/uniprot/G1RNT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LDAF1 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Membrane http://togogenome.org/gene/61853:PGPEP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HNV5|||http://purl.uniprot.org/uniprot/G1R258 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C15 family.|||Cytoplasm|||Removes 5-oxoproline from various penultimate amino acid residues except L-proline. http://togogenome.org/gene/61853:NXPE3 ^@ http://purl.uniprot.org/uniprot/A0A2I3H9Q7 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/61853:APOB ^@ http://purl.uniprot.org/uniprot/G1QIQ2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:LOC100581434 ^@ http://purl.uniprot.org/uniprot/A0A2I3HL22 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/61853:USP45 ^@ http://purl.uniprot.org/uniprot/G1RU01 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/61853:LOC100582721 ^@ http://purl.uniprot.org/uniprot/G1QWL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTF2H2 family.|||Nucleus http://togogenome.org/gene/61853:NEU1 ^@ http://purl.uniprot.org/uniprot/G1R3L8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/61853:GPR3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GEV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:USP7 ^@ http://purl.uniprot.org/uniprot/G1RGG6 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/61853:SIGIRR ^@ http://purl.uniprot.org/uniprot/G1R9Z2 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/61853:NMNAT2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GQ64|||http://purl.uniprot.org/uniprot/G1S8Q0 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/61853:VMA21 ^@ http://purl.uniprot.org/uniprot/A0A2I3H4D1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the V0 complex of the vacuolar ATPase (V-ATPase).|||Belongs to the VMA21 family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. http://togogenome.org/gene/61853:SLC25A12 ^@ http://purl.uniprot.org/uniprot/A0A2I3H8N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:GPR83 ^@ http://purl.uniprot.org/uniprot/A0A2I3GUY6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:CMC4 ^@ http://purl.uniprot.org/uniprot/A0A2I3H3X4 ^@ Similarity ^@ Belongs to the CMC4 family. http://togogenome.org/gene/61853:GDF3 ^@ http://purl.uniprot.org/uniprot/G1QZV2 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/61853:NMBR ^@ http://purl.uniprot.org/uniprot/G1RYG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:IDO1 ^@ http://purl.uniprot.org/uniprot/G1RPR1 ^@ Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family. http://togogenome.org/gene/61853:CD163 ^@ http://purl.uniprot.org/uniprot/G1QZT7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:SLC6A16 ^@ http://purl.uniprot.org/uniprot/G1QYV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/61853:KMO ^@ http://purl.uniprot.org/uniprot/A0A2I3FZG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aromatic-ring hydroxylase family. KMO subfamily.|||Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.|||Mitochondrion outer membrane http://togogenome.org/gene/61853:TGM7 ^@ http://purl.uniprot.org/uniprot/G1QYD9 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/61853:PSMC4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HCV1 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/61853:KIN ^@ http://purl.uniprot.org/uniprot/G1RMK2 ^@ Similarity ^@ Belongs to the KIN17 family. http://togogenome.org/gene/61853:CRYBA2 ^@ http://purl.uniprot.org/uniprot/G1RCN8 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/61853:GALNT6 ^@ http://purl.uniprot.org/uniprot/M3ZBY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:USP4 ^@ http://purl.uniprot.org/uniprot/G1R549|||http://purl.uniprot.org/uniprot/M3ZB69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Nucleus http://togogenome.org/gene/61853:CBR3 ^@ http://purl.uniprot.org/uniprot/G1QWH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm http://togogenome.org/gene/61853:EID2B ^@ http://purl.uniprot.org/uniprot/A0A2I3FXA3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:LOC100594097 ^@ http://purl.uniprot.org/uniprot/G1R9V1 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/61853:CD163L1 ^@ http://purl.uniprot.org/uniprot/G1QZM6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:PAQR3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HL60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/61853:AGT ^@ http://purl.uniprot.org/uniprot/G1QMC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family.|||Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.|||Secreted|||Stimulates aldosterone release. http://togogenome.org/gene/61853:BRINP1 ^@ http://purl.uniprot.org/uniprot/G1S4X0 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/61853:MRPL40 ^@ http://purl.uniprot.org/uniprot/G1QZY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL40 family.|||Mitochondrion http://togogenome.org/gene/61853:CCNQ ^@ http://purl.uniprot.org/uniprot/G1RSA2 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin-like FAM58 subfamily. http://togogenome.org/gene/61853:KDM1B ^@ http://purl.uniprot.org/uniprot/G1QLZ6 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/61853:GCHFR ^@ http://purl.uniprot.org/uniprot/H9HA00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GFRP family.|||Membrane|||Nucleus membrane|||cytosol http://togogenome.org/gene/61853:FAM98A ^@ http://purl.uniprot.org/uniprot/G1S1Q0 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/61853:PPP1R2 ^@ http://purl.uniprot.org/uniprot/G1RAE4 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 2 family. http://togogenome.org/gene/61853:LOC100583725 ^@ http://purl.uniprot.org/uniprot/A0A2I3HMN6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:MRPS26 ^@ http://purl.uniprot.org/uniprot/M3ZCK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS26 family.|||Mitochondrion http://togogenome.org/gene/61853:EXOC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GFD9|||http://purl.uniprot.org/uniprot/A0A2I3HMA3|||http://purl.uniprot.org/uniprot/G1RBD9 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/61853:OSM ^@ http://purl.uniprot.org/uniprot/A0A2I3GYK4|||http://purl.uniprot.org/uniprot/G1QTJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LIF/OSM family.|||Secreted http://togogenome.org/gene/61853:NAA30 ^@ http://purl.uniprot.org/uniprot/G1RRD1 ^@ Similarity ^@ Belongs to the acetyltransferase family. MAK3 subfamily. http://togogenome.org/gene/61853:STIM2 ^@ http://purl.uniprot.org/uniprot/A0A2I3H8Q5|||http://purl.uniprot.org/uniprot/G1S509 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:IL19 ^@ http://purl.uniprot.org/uniprot/G1QJ45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/61853:GIMAP2 ^@ http://purl.uniprot.org/uniprot/G1QUK9 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/61853:CDH11 ^@ http://purl.uniprot.org/uniprot/A0A2I3H3C5 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:ADGRG7 ^@ http://purl.uniprot.org/uniprot/A0A2I3G6N9|||http://purl.uniprot.org/uniprot/G1QR81 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:C3H6orf58 ^@ http://purl.uniprot.org/uniprot/G1RVE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LEG1 family.|||Secreted http://togogenome.org/gene/61853:ATP5PD ^@ http://purl.uniprot.org/uniprot/G1QIB9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase d subunit family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:CDK4 ^@ http://purl.uniprot.org/uniprot/G1S5W7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:UGT8 ^@ http://purl.uniprot.org/uniprot/G1S2B0 ^@ Similarity ^@ Belongs to the UDP-glycosyltransferase family. http://togogenome.org/gene/61853:TFEB ^@ http://purl.uniprot.org/uniprot/G1QYE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/61853:LIX1 ^@ http://purl.uniprot.org/uniprot/G1RWH1 ^@ Similarity ^@ Belongs to the LIX1 family. http://togogenome.org/gene/61853:WDYHV1 ^@ http://purl.uniprot.org/uniprot/G1QZT0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NTAQ1 family.|||Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.|||Monomer. http://togogenome.org/gene/61853:FOXN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GYP6 ^@ Function|||Subcellular Location Annotation ^@ Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).|||Nucleus http://togogenome.org/gene/61853:MS4A3 ^@ http://purl.uniprot.org/uniprot/A0A2I3H913|||http://purl.uniprot.org/uniprot/G1RS24 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/61853:NDUFA5 ^@ http://purl.uniprot.org/uniprot/A0A2I3HMN6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:SRF ^@ http://purl.uniprot.org/uniprot/G1QVY4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:CLRN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H394|||http://purl.uniprot.org/uniprot/A0A2I3HQG5|||http://purl.uniprot.org/uniprot/G1QSZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/61853:LOC100589443 ^@ http://purl.uniprot.org/uniprot/A0A2I3FVV7|||http://purl.uniprot.org/uniprot/G1RSV4 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/61853:CDK2AP2 ^@ http://purl.uniprot.org/uniprot/G1R3R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDK2AP family.|||Nucleus http://togogenome.org/gene/61853:PHKA1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HWT0|||http://purl.uniprot.org/uniprot/G1S931 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. http://togogenome.org/gene/61853:PHACTR1 ^@ http://purl.uniprot.org/uniprot/G1QIZ4 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/61853:HDC ^@ http://purl.uniprot.org/uniprot/A0A2I3G754|||http://purl.uniprot.org/uniprot/G1R2Y0 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/61853:IL2RG ^@ http://purl.uniprot.org/uniprot/G1QKC8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:TPPP3 ^@ http://purl.uniprot.org/uniprot/G1QXG4 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/61853:VEPH1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H471|||http://purl.uniprot.org/uniprot/G1QVH6 ^@ Similarity ^@ Belongs to the MELT/VEPH family. http://togogenome.org/gene/61853:LOC100596609 ^@ http://purl.uniprot.org/uniprot/G1RU31 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/61853:PDE4D ^@ http://purl.uniprot.org/uniprot/A0A2I3H789|||http://purl.uniprot.org/uniprot/A0A2I3HPP9|||http://purl.uniprot.org/uniprot/A0A2I3HPU2 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/61853:PIGH ^@ http://purl.uniprot.org/uniprot/G1QIV9 ^@ Similarity ^@ Belongs to the PIGH family. http://togogenome.org/gene/61853:GALNT16 ^@ http://purl.uniprot.org/uniprot/G1QLF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:VWDE ^@ http://purl.uniprot.org/uniprot/G1S2I2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:DUS3L ^@ http://purl.uniprot.org/uniprot/G1RTY5 ^@ Similarity ^@ Belongs to the dus family. Dus3 subfamily. http://togogenome.org/gene/61853:TMEM115 ^@ http://purl.uniprot.org/uniprot/A0A2I3HS67 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:ASB15 ^@ http://purl.uniprot.org/uniprot/G1RND2 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/61853:ORAI3 ^@ http://purl.uniprot.org/uniprot/A0A2I3G9U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Orai family.|||Membrane http://togogenome.org/gene/61853:RAP2B ^@ http://purl.uniprot.org/uniprot/A0A2I3H298 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/61853:SGTA ^@ http://purl.uniprot.org/uniprot/G1QPR8 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/61853:SLCO4C1 ^@ http://purl.uniprot.org/uniprot/G1RJ03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:SPACA5B ^@ http://purl.uniprot.org/uniprot/G1QTF5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/61853:MICOS10 ^@ http://purl.uniprot.org/uniprot/G1R8Q3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic10 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:ARL6IP5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GLS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/61853:UBE2D2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GKM9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/61853:YIF1A ^@ http://purl.uniprot.org/uniprot/A0A2I3GEJ2|||http://purl.uniprot.org/uniprot/G1R2D0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:NUMB ^@ http://purl.uniprot.org/uniprot/A0A2I3HE81|||http://purl.uniprot.org/uniprot/G1QRY2 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Plays a role in the process of neurogenesis. http://togogenome.org/gene/61853:ABCB5 ^@ http://purl.uniprot.org/uniprot/G1S455 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:BANF1 ^@ http://purl.uniprot.org/uniprot/G1R238 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:PPAN ^@ http://purl.uniprot.org/uniprot/G1RN34 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/61853:CHRDL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GGV1 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/61853:ACSS2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GS90|||http://purl.uniprot.org/uniprot/A0A2I3H084 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/61853:SLC6A15 ^@ http://purl.uniprot.org/uniprot/G1QZV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.|||Membrane http://togogenome.org/gene/61853:FOXN4 ^@ http://purl.uniprot.org/uniprot/G1QLV9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:LYPLA1 ^@ http://purl.uniprot.org/uniprot/G1QJY8 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/61853:PMPCA ^@ http://purl.uniprot.org/uniprot/G1RA14 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/61853:ODF2 ^@ http://purl.uniprot.org/uniprot/G1S747 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ODF2 family.|||centrosome http://togogenome.org/gene/61853:CFTR ^@ http://purl.uniprot.org/uniprot/G1RLX5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.|||Cell membrane|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.|||Membrane|||Recycling endosome membrane http://togogenome.org/gene/61853:OXSR1 ^@ http://purl.uniprot.org/uniprot/G1QZY4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/61853:PCBD2 ^@ http://purl.uniprot.org/uniprot/A0A2I3H4V4 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/61853:FNIP2 ^@ http://purl.uniprot.org/uniprot/G1R3P9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNIP family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/61853:VPS29 ^@ http://purl.uniprot.org/uniprot/A0A2I3GK26|||http://purl.uniprot.org/uniprot/A0A2I3GPG3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.|||Belongs to the VPS29 family.|||Endosome membrane http://togogenome.org/gene/61853:KRT72 ^@ http://purl.uniprot.org/uniprot/A0A2I3H7M8|||http://purl.uniprot.org/uniprot/G1S7Q2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/61853:ATXN1L ^@ http://purl.uniprot.org/uniprot/G1S9T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATXN1 family.|||Nucleus http://togogenome.org/gene/61853:CTPS1 ^@ http://purl.uniprot.org/uniprot/G1RNR2 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/61853:PRICKLE1 ^@ http://purl.uniprot.org/uniprot/G1S8F2 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/61853:LOC100604810 ^@ http://purl.uniprot.org/uniprot/G1SAC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:TUT1 ^@ http://purl.uniprot.org/uniprot/G1QUG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B-like family.|||Nucleus speckle|||nucleolus http://togogenome.org/gene/61853:RAX2 ^@ http://purl.uniprot.org/uniprot/G1QR43 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:YKT6 ^@ http://purl.uniprot.org/uniprot/G1QU42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. http://togogenome.org/gene/61853:PINLYP ^@ http://purl.uniprot.org/uniprot/G1QLW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNF-like-inhibitor family.|||Secreted http://togogenome.org/gene/61853:KHDC4 ^@ http://purl.uniprot.org/uniprot/G1RNS1 ^@ Similarity ^@ Belongs to the KHDC4 family. http://togogenome.org/gene/61853:LOC100589670 ^@ http://purl.uniprot.org/uniprot/G1SCC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:GATM ^@ http://purl.uniprot.org/uniprot/A0A2I3G013 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the amidinotransferase family.|||Homodimer.|||Mitochondrion inner membrane|||Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain. http://togogenome.org/gene/61853:LOC100596445 ^@ http://purl.uniprot.org/uniprot/G1R451 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/61853:CNOT9 ^@ http://purl.uniprot.org/uniprot/A0A2I3HXU2|||http://purl.uniprot.org/uniprot/G1RBS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT9 family.|||P-body http://togogenome.org/gene/61853:PGLYRP1 ^@ http://purl.uniprot.org/uniprot/G1QPS3 ^@ Function|||Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.|||Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. http://togogenome.org/gene/61853:SLA2 ^@ http://purl.uniprot.org/uniprot/G1R2L3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:TSPO ^@ http://purl.uniprot.org/uniprot/G1S1Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/61853:TPM3 ^@ http://purl.uniprot.org/uniprot/A0A2I3FRR0|||http://purl.uniprot.org/uniprot/A0A2I3G1Q7|||http://purl.uniprot.org/uniprot/A0A2I3GH21|||http://purl.uniprot.org/uniprot/A0A2I3GVM9|||http://purl.uniprot.org/uniprot/A0A2I3H3U0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/61853:MAP2 ^@ http://purl.uniprot.org/uniprot/G1R6A0 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/61853:LPAR1 ^@ http://purl.uniprot.org/uniprot/G1S6S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cell surface|||Endosome|||Membrane http://togogenome.org/gene/61853:ATAD2 ^@ http://purl.uniprot.org/uniprot/G1QZR9 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/61853:RNF168 ^@ http://purl.uniprot.org/uniprot/G1QLL3 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ According to a well-established model, RNF168 cannot initiate H2A 'Lys-63'-linked ubiquitination and is recruited following RNF8-dependent histone ubiquitination to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.|||Belongs to the RNF168 family.|||E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).|||Monomer. Interacts with UBE2N/UBC13.|||Nucleus|||Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs).|||The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs).|||Ubiquitinated. http://togogenome.org/gene/61853:RPS29 ^@ http://purl.uniprot.org/uniprot/A0A2I3G8X8|||http://purl.uniprot.org/uniprot/G1RMQ5 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/61853:CXCL3 ^@ http://purl.uniprot.org/uniprot/G1R8Y5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/61853:UBE2D4 ^@ http://purl.uniprot.org/uniprot/G1QT42 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/61853:AGL ^@ http://purl.uniprot.org/uniprot/G1RLT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycogen debranching enzyme family.|||Cytoplasm|||Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. http://togogenome.org/gene/61853:KIF5C ^@ http://purl.uniprot.org/uniprot/A0A2I3HDE4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/61853:GPX5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GFP2|||http://purl.uniprot.org/uniprot/G1QX84 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/61853:TRIT1 ^@ http://purl.uniprot.org/uniprot/G1RN30 ^@ Function|||Similarity ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37. http://togogenome.org/gene/61853:PKD2L2 ^@ http://purl.uniprot.org/uniprot/G1RB69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polycystin family.|||Membrane http://togogenome.org/gene/61853:PPFIA1 ^@ http://purl.uniprot.org/uniprot/M3ZB00 ^@ Similarity ^@ Belongs to the liprin family. Liprin-alpha subfamily. http://togogenome.org/gene/61853:RPAIN ^@ http://purl.uniprot.org/uniprot/A0A2I3HY77|||http://purl.uniprot.org/uniprot/G1RCV2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:USP1 ^@ http://purl.uniprot.org/uniprot/G1RY27 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/61853:EDNRA ^@ http://purl.uniprot.org/uniprot/G1R0W4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/61853:AGO1 ^@ http://purl.uniprot.org/uniprot/G1RK81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the argonaute family.|||P-body http://togogenome.org/gene/61853:LOC100591859 ^@ http://purl.uniprot.org/uniprot/G1SAN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:VTI1B ^@ http://purl.uniprot.org/uniprot/G1QJ50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/61853:ACTL7A ^@ http://purl.uniprot.org/uniprot/G1SBD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||Golgi apparatus|||May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.|||Nucleus|||cytoskeleton http://togogenome.org/gene/61853:CD207 ^@ http://purl.uniprot.org/uniprot/G1RGW2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:FBLN2 ^@ http://purl.uniprot.org/uniprot/G1QYF7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fibulin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/61853:HOXA9 ^@ http://purl.uniprot.org/uniprot/G1RY99 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/61853:ME3 ^@ http://purl.uniprot.org/uniprot/G1S289 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/61853:PLAC1 ^@ http://purl.uniprot.org/uniprot/G1QND4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PLAC1 family.|||Secreted http://togogenome.org/gene/61853:TUBA8 ^@ http://purl.uniprot.org/uniprot/A0A2I3HFV6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/61853:GSTM4 ^@ http://purl.uniprot.org/uniprot/G1QSD7 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Mu family.|||Homodimer. http://togogenome.org/gene/61853:STX7 ^@ http://purl.uniprot.org/uniprot/G1RWV0 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/61853:TNFRSF1A ^@ http://purl.uniprot.org/uniprot/A0A2I3GEI2 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:WNT3 ^@ http://purl.uniprot.org/uniprot/G1QYC8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/61853:SH3GL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HW13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Membrane http://togogenome.org/gene/61853:SH3BP4 ^@ http://purl.uniprot.org/uniprot/G1RB37 ^@ Subcellular Location Annotation ^@ Nucleus|||Vesicle|||clathrin-coated pit|||clathrin-coated vesicle http://togogenome.org/gene/61853:ANTXR2 ^@ http://purl.uniprot.org/uniprot/G1RAV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATR family.|||Membrane http://togogenome.org/gene/61853:DIS3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GDS2|||http://purl.uniprot.org/uniprot/G1S1W4 ^@ Similarity ^@ Belongs to the RNR ribonuclease family. http://togogenome.org/gene/61853:CCT8 ^@ http://purl.uniprot.org/uniprot/A0A2I3HE70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||cilium basal body http://togogenome.org/gene/61853:AVPR1B ^@ http://purl.uniprot.org/uniprot/G1QHX5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. http://togogenome.org/gene/61853:RSAD2 ^@ http://purl.uniprot.org/uniprot/G1RZP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RSAD2 family.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion inner membrane|||Mitochondrion outer membrane http://togogenome.org/gene/61853:RPL22L1 ^@ http://purl.uniprot.org/uniprot/G1QZL8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/61853:RRM1 ^@ http://purl.uniprot.org/uniprot/G1S6A0 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/61853:RTF2 ^@ http://purl.uniprot.org/uniprot/G1R5V8 ^@ Similarity|||Subunit ^@ Belongs to the rtf2 family.|||Interacts with DDI2; probably also interacts with DDI1. http://togogenome.org/gene/61853:LIN28B ^@ http://purl.uniprot.org/uniprot/G1RVA8 ^@ Similarity ^@ Belongs to the lin-28 family. http://togogenome.org/gene/61853:MED30 ^@ http://purl.uniprot.org/uniprot/G1QY76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 30 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/61853:GUCY2D ^@ http://purl.uniprot.org/uniprot/G1RFH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane|||Photoreceptor outer segment membrane http://togogenome.org/gene/61853:CARTPT ^@ http://purl.uniprot.org/uniprot/G1QWY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CART family.|||Secreted http://togogenome.org/gene/61853:PDF ^@ http://purl.uniprot.org/uniprot/G1R0B4 ^@ Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. http://togogenome.org/gene/61853:SNAP91 ^@ http://purl.uniprot.org/uniprot/A0A2I3H6N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PICALM/SNAP91 family.|||Membrane http://togogenome.org/gene/61853:IL1RAPL2 ^@ http://purl.uniprot.org/uniprot/G1RTG0 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/61853:NFX1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H3Z3|||http://purl.uniprot.org/uniprot/G1QZ68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NFX1 family.|||Nucleus http://togogenome.org/gene/61853:LOC100586163 ^@ http://purl.uniprot.org/uniprot/G1QUV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/61853:IL12RB2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GHI5|||http://purl.uniprot.org/uniprot/A0A2I3H044|||http://purl.uniprot.org/uniprot/G1RDE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/61853:EEF2K ^@ http://purl.uniprot.org/uniprot/A0A2I3H1F9 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. Alpha-type protein kinase family.|||Monomer or homodimer.|||Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent. http://togogenome.org/gene/61853:WDR82 ^@ http://purl.uniprot.org/uniprot/G1R634 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SWD2 family.|||Nucleus http://togogenome.org/gene/61853:TAT ^@ http://purl.uniprot.org/uniprot/G1R1D7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. http://togogenome.org/gene/61853:HOXC10 ^@ http://purl.uniprot.org/uniprot/G1S7G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/61853:ZPR1 ^@ http://purl.uniprot.org/uniprot/G1R6X0 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/61853:ARL5A ^@ http://purl.uniprot.org/uniprot/G1RK72 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/61853:TRIM2 ^@ http://purl.uniprot.org/uniprot/G1R1V4 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/61853:SLC6A7 ^@ http://purl.uniprot.org/uniprot/G1RH19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/61853:PLPP1 ^@ http://purl.uniprot.org/uniprot/G1QLH2|||http://purl.uniprot.org/uniprot/M3ZC32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/61853:ERGIC2 ^@ http://purl.uniprot.org/uniprot/G1R0W5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/61853:TGFA ^@ http://purl.uniprot.org/uniprot/G1RGR8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:LOC100602470 ^@ http://purl.uniprot.org/uniprot/A0A2I3H3R6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Refilin family.|||Interacts with FLNA and FLNB.|||cytoskeleton http://togogenome.org/gene/61853:ACTL8 ^@ http://purl.uniprot.org/uniprot/G1R8F6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/61853:LOC100593830 ^@ http://purl.uniprot.org/uniprot/G1RRH1 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/61853:EXOSC3 ^@ http://purl.uniprot.org/uniprot/G1QTK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP40 family.|||Cytoplasm|||nucleolus http://togogenome.org/gene/61853:FABP1 ^@ http://purl.uniprot.org/uniprot/G1QRN1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.|||Cytoplasm|||Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. http://togogenome.org/gene/61853:KCNAB1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G3J1|||http://purl.uniprot.org/uniprot/A0A2I3GYP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/61853:TFF2 ^@ http://purl.uniprot.org/uniprot/G1RWR8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:CTTNBP2 ^@ http://purl.uniprot.org/uniprot/G1RM35 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.|||Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.|||cell cortex|||dendritic spine http://togogenome.org/gene/61853:LZIC ^@ http://purl.uniprot.org/uniprot/G1RDW0 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/61853:CRYZ ^@ http://purl.uniprot.org/uniprot/A0A2I3GPF1|||http://purl.uniprot.org/uniprot/G1REH3 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/61853:IZUMO4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GKS1|||http://purl.uniprot.org/uniprot/G1QNE0 ^@ Similarity ^@ Belongs to the Izumo family. http://togogenome.org/gene/61853:ACTG2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G1L5 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/61853:EIF2B1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HZ59 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2B alpha/beta/delta subunits family.|||Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.|||Complex of five different subunits; alpha, beta, gamma, delta and epsilon. http://togogenome.org/gene/61853:SLC4A8 ^@ http://purl.uniprot.org/uniprot/G1S7T8 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/61853:EML5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GLG1|||http://purl.uniprot.org/uniprot/G1S518 ^@ Function|||Similarity ^@ Belongs to the WD repeat EMAP family.|||May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. http://togogenome.org/gene/61853:BTN2A1 ^@ http://purl.uniprot.org/uniprot/G1QSX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/61853:CD74 ^@ http://purl.uniprot.org/uniprot/G1RHB8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:RXRG ^@ http://purl.uniprot.org/uniprot/G1RX84 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Homodimer. Heterodimer; with a rar molecule.|||Nucleus|||Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. http://togogenome.org/gene/61853:TMEM184C ^@ http://purl.uniprot.org/uniprot/A0A2I3HKG5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:PDS5A ^@ http://purl.uniprot.org/uniprot/G1S5L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDS5 family.|||Nucleus http://togogenome.org/gene/61853:ERRFI1 ^@ http://purl.uniprot.org/uniprot/G1RBZ6 ^@ Subcellular Location Annotation ^@ Membrane|||Nucleus http://togogenome.org/gene/61853:BTK ^@ http://purl.uniprot.org/uniprot/A0A2I3H7M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cytoplasm http://togogenome.org/gene/61853:CSMD3 ^@ http://purl.uniprot.org/uniprot/G1QXV3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:KIF18A ^@ http://purl.uniprot.org/uniprot/G1S865 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/61853:LOC100584964 ^@ http://purl.uniprot.org/uniprot/G1SC35 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:SLC39A3 ^@ http://purl.uniprot.org/uniprot/A0A2I3H310 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:FOXI1 ^@ http://purl.uniprot.org/uniprot/G1QZ13 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:RPE65 ^@ http://purl.uniprot.org/uniprot/G1RDQ9 ^@ Cofactor|||Similarity ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/61853:PDLIM3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GZI6|||http://purl.uniprot.org/uniprot/G1RKG0 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/61853:PIGV ^@ http://purl.uniprot.org/uniprot/G1RDW5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGV family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.|||Membrane http://togogenome.org/gene/61853:LOC100596610 ^@ http://purl.uniprot.org/uniprot/A0A2I3GD05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/61853:ZBTB8OS ^@ http://purl.uniprot.org/uniprot/A0A2I3H0B6 ^@ Similarity|||Subunit ^@ Belongs to the archease family.|||Component of the tRNA-splicing ligase complex. http://togogenome.org/gene/61853:TM9SF4 ^@ http://purl.uniprot.org/uniprot/G1RFB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/61853:FN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G9B0|||http://purl.uniprot.org/uniprot/A0A2I3GKG9|||http://purl.uniprot.org/uniprot/G1R6M9|||http://purl.uniprot.org/uniprot/G1R6N1 ^@ Function ^@ Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling. http://togogenome.org/gene/61853:SLCO1C1 ^@ http://purl.uniprot.org/uniprot/G1QXI9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:HGF ^@ http://purl.uniprot.org/uniprot/A0A2I3GPI4|||http://purl.uniprot.org/uniprot/G1RXL8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. http://togogenome.org/gene/61853:OSTC ^@ http://purl.uniprot.org/uniprot/G1RR23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OSTC family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. http://togogenome.org/gene/61853:ZSCAN29 ^@ http://purl.uniprot.org/uniprot/G1QYG8 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/61853:C12H1orf52 ^@ http://purl.uniprot.org/uniprot/G1RG63 ^@ Similarity ^@ Belongs to the UPF0690 family. http://togogenome.org/gene/61853:OSBPL9 ^@ http://purl.uniprot.org/uniprot/A0A2I3GH05|||http://purl.uniprot.org/uniprot/A0A2I3GMC2|||http://purl.uniprot.org/uniprot/A0A2I3I083|||http://purl.uniprot.org/uniprot/G1S285 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/61853:EPO ^@ http://purl.uniprot.org/uniprot/G1RMP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPO/TPO family.|||Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.|||Secreted http://togogenome.org/gene/61853:GSTO1 ^@ http://purl.uniprot.org/uniprot/G1RZH2 ^@ Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). http://togogenome.org/gene/61853:ORMDL1 ^@ http://purl.uniprot.org/uniprot/G1R4D6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/61853:PTGDS ^@ http://purl.uniprot.org/uniprot/G1RBR0 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/61853:TRPV5 ^@ http://purl.uniprot.org/uniprot/G1QRE2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:UMODL1 ^@ http://purl.uniprot.org/uniprot/G1RWQ4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:PPCS ^@ http://purl.uniprot.org/uniprot/G1RNX6 ^@ Similarity ^@ Belongs to the PPC synthetase family. http://togogenome.org/gene/61853:ASZ1 ^@ http://purl.uniprot.org/uniprot/Q07DX6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity). http://togogenome.org/gene/61853:LOC100600529 ^@ http://purl.uniprot.org/uniprot/G1SCA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:LOC100592919 ^@ http://purl.uniprot.org/uniprot/G1S988 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:SLC5A10 ^@ http://purl.uniprot.org/uniprot/A0A2I3GYA4|||http://purl.uniprot.org/uniprot/G1RS13|||http://purl.uniprot.org/uniprot/G1RS29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:POC5 ^@ http://purl.uniprot.org/uniprot/A0A2I3HAH0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POC5 family.|||Essential for the assembly of the distal half of centrioles, required for centriole elongation.|||centriole http://togogenome.org/gene/61853:ELOC ^@ http://purl.uniprot.org/uniprot/A0A2I3GHI4 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/61853:APOH ^@ http://purl.uniprot.org/uniprot/G1QHF4 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:FXYD6 ^@ http://purl.uniprot.org/uniprot/G1R6Z2 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/61853:IFT57 ^@ http://purl.uniprot.org/uniprot/A0A2I3G7G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT57 family.|||cilium basal body http://togogenome.org/gene/61853:PLD1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HGH2 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/61853:DEFB119 ^@ http://purl.uniprot.org/uniprot/A0A2I3HW98|||http://purl.uniprot.org/uniprot/G1REJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/61853:UTP11 ^@ http://purl.uniprot.org/uniprot/A0A2I3HVL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP11 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/61853:LOC100603673 ^@ http://purl.uniprot.org/uniprot/G1S7S0 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/61853:ANP32B ^@ http://purl.uniprot.org/uniprot/G1S4Y8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/61853:SLC12A5 ^@ http://purl.uniprot.org/uniprot/A0A2I3G4J5|||http://purl.uniprot.org/uniprot/A0A2I3GCQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/61853:LOC100590776 ^@ http://purl.uniprot.org/uniprot/A0A2I3H0B9 ^@ Similarity ^@ Belongs to the TACO1 family. http://togogenome.org/gene/61853:CPXM2 ^@ http://purl.uniprot.org/uniprot/G1S5D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Secreted http://togogenome.org/gene/61853:ABCG4 ^@ http://purl.uniprot.org/uniprot/G1R740 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/61853:CER1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HMH1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:MAPRE2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GFL2|||http://purl.uniprot.org/uniprot/G1R377 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/61853:DBNDD2 ^@ http://purl.uniprot.org/uniprot/G1R4Q7 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/61853:MED17 ^@ http://purl.uniprot.org/uniprot/G1R628 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 17 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/61853:NFYA ^@ http://purl.uniprot.org/uniprot/G1QYT1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NFYA/HAP2 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.|||Heterotrimer.|||Nucleus http://togogenome.org/gene/61853:GAP43 ^@ http://purl.uniprot.org/uniprot/A0A2I3GEN9|||http://purl.uniprot.org/uniprot/G1QXX8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neuromodulin family.|||Cell membrane|||Cytoplasm|||Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.|||Membrane|||Palmitoylated. Palmitoylation is essential for plasma membrane association.|||Perikaryon|||Synapse|||This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.|||axon|||dendrite|||filopodium membrane|||growth cone membrane http://togogenome.org/gene/61853:SS18L2 ^@ http://purl.uniprot.org/uniprot/G1R1K2 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/61853:FITM2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HA86 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:LOC100597957 ^@ http://purl.uniprot.org/uniprot/A0A7R8GUU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/61853:CPSF3 ^@ http://purl.uniprot.org/uniprot/A0A2I3G999|||http://purl.uniprot.org/uniprot/M3Z9C6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:GPR161 ^@ http://purl.uniprot.org/uniprot/A0A2I3FY44|||http://purl.uniprot.org/uniprot/A0A2I3H0D1|||http://purl.uniprot.org/uniprot/A0A2I3HQ48 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:TNN ^@ http://purl.uniprot.org/uniprot/G1RZK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family.|||extracellular matrix http://togogenome.org/gene/61853:SST ^@ http://purl.uniprot.org/uniprot/G1R4N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/61853:LOC100596946 ^@ http://purl.uniprot.org/uniprot/A0A2I3HH18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/61853:ZRANB2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G9J6|||http://purl.uniprot.org/uniprot/G1RE58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZRANB2 family.|||Nucleus|||Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection. http://togogenome.org/gene/61853:MCOLN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GXL0|||http://purl.uniprot.org/uniprot/G1RG44 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/61853:YPEL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GK32 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/61853:NEXMIF ^@ http://purl.uniprot.org/uniprot/G1QJZ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:KIZ ^@ http://purl.uniprot.org/uniprot/A0A2I3HIR1|||http://purl.uniprot.org/uniprot/G1RG02 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the kizuna family.|||Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.|||centrosome|||cilium basal body http://togogenome.org/gene/61853:DNAJC16 ^@ http://purl.uniprot.org/uniprot/G1R7U4|||http://purl.uniprot.org/uniprot/M3ZB76 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Plays an important role in regulating the size of autophagosomes during the formation process. http://togogenome.org/gene/61853:KCNH1 ^@ http://purl.uniprot.org/uniprot/G1QPR1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:UBE4A ^@ http://purl.uniprot.org/uniprot/G1R708 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm|||The U-box domain is required for the ubiquitin protein ligase activity.|||Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. http://togogenome.org/gene/61853:MID1 ^@ http://purl.uniprot.org/uniprot/G1RCH1 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/61853:NAB1 ^@ http://purl.uniprot.org/uniprot/A0A2I3FXT4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAB family.|||Homomultimers may associate with EGR1 bound to DNA.|||Nucleus http://togogenome.org/gene/61853:PNPLA1 ^@ http://purl.uniprot.org/uniprot/G1RCT3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:LOC100593588 ^@ http://purl.uniprot.org/uniprot/G1S7R3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/61853:SASS6 ^@ http://purl.uniprot.org/uniprot/G1RM01 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/61853:RANBP17 ^@ http://purl.uniprot.org/uniprot/G1QHG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:ENTPD3 ^@ http://purl.uniprot.org/uniprot/G1R107 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/61853:ATG101 ^@ http://purl.uniprot.org/uniprot/G1S7S7 ^@ Similarity ^@ Belongs to the ATG101 family. http://togogenome.org/gene/61853:NAA25 ^@ http://purl.uniprot.org/uniprot/G1QGM0 ^@ Similarity ^@ Belongs to the MDM20/NAA25 family. http://togogenome.org/gene/61853:DCP2 ^@ http://purl.uniprot.org/uniprot/G1RLL2 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DCP2 subfamily. http://togogenome.org/gene/61853:ACSM4 ^@ http://purl.uniprot.org/uniprot/G1QZH3 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/61853:ASB8 ^@ http://purl.uniprot.org/uniprot/G1S889 ^@ Function|||Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family.|||May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/61853:TAF1A ^@ http://purl.uniprot.org/uniprot/M3ZBB8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits.|||Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.|||Nucleus http://togogenome.org/gene/61853:NNT ^@ http://purl.uniprot.org/uniprot/G1RHY8 ^@ Similarity ^@ In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/61853:MRPS36 ^@ http://purl.uniprot.org/uniprot/A0A2I3GF74 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/61853:MED14 ^@ http://purl.uniprot.org/uniprot/G1QMM2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 14 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/61853:ECHS1 ^@ http://purl.uniprot.org/uniprot/G1QP93 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/61853:TSG101 ^@ http://purl.uniprot.org/uniprot/G1S7V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.|||Membrane http://togogenome.org/gene/61853:CES3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBM5|||http://purl.uniprot.org/uniprot/G1QVY9 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/61853:UNC5D ^@ http://purl.uniprot.org/uniprot/G1RNB2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/61853:PHYH ^@ http://purl.uniprot.org/uniprot/G1RNQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UCMA family.|||May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.|||extracellular matrix http://togogenome.org/gene/61853:MOB1B ^@ http://purl.uniprot.org/uniprot/A0A2I3H2X7 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/61853:CDH3 ^@ http://purl.uniprot.org/uniprot/G1QZQ9 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:ACAD9 ^@ http://purl.uniprot.org/uniprot/G1RWC4 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/61853:LOC100593890 ^@ http://purl.uniprot.org/uniprot/A0A2I3GNS3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:BPGM ^@ http://purl.uniprot.org/uniprot/G1RRM9 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/61853:CKS1B ^@ http://purl.uniprot.org/uniprot/G1RLC1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/61853:STT3A ^@ http://purl.uniprot.org/uniprot/G1R799 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/61853:SHCBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HYL8 ^@ Subcellular Location Annotation ^@ spindle http://togogenome.org/gene/61853:FREM2 ^@ http://purl.uniprot.org/uniprot/G1QQA3 ^@ Similarity ^@ Belongs to the FRAS1 family. http://togogenome.org/gene/61853:LOC100603491 ^@ http://purl.uniprot.org/uniprot/G1S9K3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:GCNT4 ^@ http://purl.uniprot.org/uniprot/G1S9D8 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:CAMLG ^@ http://purl.uniprot.org/uniprot/G1R9Q3 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells. http://togogenome.org/gene/61853:FMO1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBN2|||http://purl.uniprot.org/uniprot/G1RYT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:MASP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GNR6|||http://purl.uniprot.org/uniprot/A0A2I3GQD9|||http://purl.uniprot.org/uniprot/G1R4M8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:INO80D ^@ http://purl.uniprot.org/uniprot/A0A2I3G6D8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:GRPEL1 ^@ http://purl.uniprot.org/uniprot/G1RMB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/61853:BMP10 ^@ http://purl.uniprot.org/uniprot/G1RG92 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/61853:ITGA4 ^@ http://purl.uniprot.org/uniprot/G1R393 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/61853:TOMM22 ^@ http://purl.uniprot.org/uniprot/G1RYT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom22 family.|||Mitochondrion outer membrane http://togogenome.org/gene/61853:TNKS2 ^@ http://purl.uniprot.org/uniprot/M3ZAS3 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/61853:ATP1A2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HW78 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:TRADD ^@ http://purl.uniprot.org/uniprot/G1QWB5 ^@ Subcellular Location Annotation ^@ Nucleus|||cytoskeleton http://togogenome.org/gene/61853:RRAD ^@ http://purl.uniprot.org/uniprot/G1QVR6 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/61853:RPS19BP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3I037 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AROS family.|||nucleolus http://togogenome.org/gene/61853:TBX4 ^@ http://purl.uniprot.org/uniprot/G1QHV7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/61853:ARRB1 ^@ http://purl.uniprot.org/uniprot/G1S4Y2 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/61853:ERN1 ^@ http://purl.uniprot.org/uniprot/G1RYK6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:LOC100602452 ^@ http://purl.uniprot.org/uniprot/G1S992 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:MKX ^@ http://purl.uniprot.org/uniprot/G1S535 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:GABRG3 ^@ http://purl.uniprot.org/uniprot/G1RHV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/61853:CCM2 ^@ http://purl.uniprot.org/uniprot/G1QVN9 ^@ Similarity ^@ Belongs to the CCM2 family. http://togogenome.org/gene/61853:IL5RA ^@ http://purl.uniprot.org/uniprot/G1QSI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 5 subfamily.|||Membrane http://togogenome.org/gene/61853:GPHA2 ^@ http://purl.uniprot.org/uniprot/G1R030 ^@ Caution|||Similarity ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:PFDN5 ^@ http://purl.uniprot.org/uniprot/A0A2I3HVV0|||http://purl.uniprot.org/uniprot/G1S7K1 ^@ Similarity ^@ Belongs to the prefoldin subunit alpha family. http://togogenome.org/gene/61853:IL13 ^@ http://purl.uniprot.org/uniprot/A0A2I3GGK5|||http://purl.uniprot.org/uniprot/A0A2I3GIU9 ^@ Subunit ^@ Interacts with IL13RA2. http://togogenome.org/gene/61853:FAM189A1 ^@ http://purl.uniprot.org/uniprot/G1RPE3 ^@ Similarity ^@ Belongs to the ENTREP family. http://togogenome.org/gene/61853:PTGS2 ^@ http://purl.uniprot.org/uniprot/G1S8S7 ^@ Caution|||Similarity ^@ Belongs to the prostaglandin G/H synthase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:ETNPPL ^@ http://purl.uniprot.org/uniprot/G1RR18 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/61853:MAF1 ^@ http://purl.uniprot.org/uniprot/G1RHQ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAF1 family.|||Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.|||Nucleus http://togogenome.org/gene/61853:MATN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GRE6|||http://purl.uniprot.org/uniprot/G1QP89 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:GCNT2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GIE0|||http://purl.uniprot.org/uniprot/G1QI76|||http://purl.uniprot.org/uniprot/M3ZBD0 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:ACBD5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GU90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.|||Belongs to the ATG37 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/61853:USP3 ^@ http://purl.uniprot.org/uniprot/G1RNW6 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/61853:MTERF1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HH87 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/61853:CASKIN2 ^@ http://purl.uniprot.org/uniprot/G1QK01 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:GRIN2A ^@ http://purl.uniprot.org/uniprot/A0A2I3HEG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/61853:GTF2E2 ^@ http://purl.uniprot.org/uniprot/G1RMM8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFIIE beta subunit family.|||Nucleus|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.|||Tetramer of two alpha and two beta chains. http://togogenome.org/gene/61853:SNCA ^@ http://purl.uniprot.org/uniprot/G1RW17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synuclein family.|||Membrane|||Nucleus|||Secreted|||Synapse|||axon http://togogenome.org/gene/61853:LOC100579584 ^@ http://purl.uniprot.org/uniprot/G1R127 ^@ Caution|||Function|||Similarity|||Subunit ^@ As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.|||Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Tetramer of two alpha and two beta chains; disulfide-linked (By similarity). The hemoglobin/haptoglobin complex is composed of a haptoglobin dimer bound to two hemoglobin alpha-beta dimers (By similarity). Interacts with CD163 (By similarity). Interacts with ERGIC3. http://togogenome.org/gene/61853:EGFL6 ^@ http://purl.uniprot.org/uniprot/G1RD59 ^@ Caution|||Similarity ^@ Belongs to the nephronectin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:IRAK4 ^@ http://purl.uniprot.org/uniprot/G1S8E5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.|||Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.|||Cytoplasm|||Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. http://togogenome.org/gene/61853:RANGRF ^@ http://purl.uniprot.org/uniprot/A0A2I3GLJ3 ^@ Similarity ^@ Belongs to the MOG1 family. http://togogenome.org/gene/61853:BMP8B ^@ http://purl.uniprot.org/uniprot/G1RN07 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/61853:PDHX ^@ http://purl.uniprot.org/uniprot/G1S8E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/61853:LOC100593892 ^@ http://purl.uniprot.org/uniprot/A0A2I3G0M1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/61853:LOC100596228 ^@ http://purl.uniprot.org/uniprot/G1RYY5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/61853:SENP3 ^@ http://purl.uniprot.org/uniprot/G1REG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C48 family.|||nucleolus http://togogenome.org/gene/61853:TTC26 ^@ http://purl.uniprot.org/uniprot/G1RV49 ^@ Similarity ^@ Belongs to the IFT56 family. http://togogenome.org/gene/61853:HNRNPF ^@ http://purl.uniprot.org/uniprot/G1SBQ3 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/61853:DHRS9 ^@ http://purl.uniprot.org/uniprot/G1QXL3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/61853:KHDC1L ^@ http://purl.uniprot.org/uniprot/G1QKD7 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/61853:PMM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H620 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/61853:APOO ^@ http://purl.uniprot.org/uniprot/G1RG77 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:LOC100597482 ^@ http://purl.uniprot.org/uniprot/G1SCA2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:MX1 ^@ http://purl.uniprot.org/uniprot/G1RBH6|||http://purl.uniprot.org/uniprot/K4JR57 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/61853:FGF13 ^@ http://purl.uniprot.org/uniprot/A0A2I3FQR4|||http://purl.uniprot.org/uniprot/A0A2I3HH88 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/61853:KCNMA1 ^@ http://purl.uniprot.org/uniprot/G1S4S4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.|||Membrane http://togogenome.org/gene/61853:RTN4IP1 ^@ http://purl.uniprot.org/uniprot/G1RSG7 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/61853:PARG ^@ http://purl.uniprot.org/uniprot/A0A2I3HT36 ^@ Similarity ^@ Belongs to the poly(ADP-ribose) glycohydrolase family. http://togogenome.org/gene/61853:RAB38 ^@ http://purl.uniprot.org/uniprot/G1S235 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/61853:CD79B ^@ http://purl.uniprot.org/uniprot/A0A2I3G367|||http://purl.uniprot.org/uniprot/G1RYQ4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:NKG7 ^@ http://purl.uniprot.org/uniprot/A0A2I3GN47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/61853:PTGIS ^@ http://purl.uniprot.org/uniprot/A0A2I3I0B0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).|||Endoplasmic reticulum membrane http://togogenome.org/gene/61853:MEGF11 ^@ http://purl.uniprot.org/uniprot/G1RQY2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:TIGD4 ^@ http://purl.uniprot.org/uniprot/G1R1S0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:SDHAF3 ^@ http://purl.uniprot.org/uniprot/G1S1M7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I LYR family. SDHAF3 subfamily.|||Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. http://togogenome.org/gene/61853:CACNB4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GDT9 ^@ Similarity ^@ Belongs to the calcium channel beta subunit family. http://togogenome.org/gene/61853:AIFM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HPS1|||http://purl.uniprot.org/uniprot/G1RZ98 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase family. http://togogenome.org/gene/61853:NUP58 ^@ http://purl.uniprot.org/uniprot/A0A2I3GIX1 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/61853:TLE3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GKB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/61853:KCNJ13 ^@ http://purl.uniprot.org/uniprot/G1RW76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/61853:LOC100607246 ^@ http://purl.uniprot.org/uniprot/G1RYN2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:ST13 ^@ http://purl.uniprot.org/uniprot/G1RZN4 ^@ Similarity ^@ Belongs to the FAM10 family. http://togogenome.org/gene/61853:CSRNP3 ^@ http://purl.uniprot.org/uniprot/G1QSF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/61853:BZW1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GJS9 ^@ Similarity ^@ Belongs to the BZW family. http://togogenome.org/gene/61853:SPPL2A ^@ http://purl.uniprot.org/uniprot/G1R3C1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/61853:ERLEC1 ^@ http://purl.uniprot.org/uniprot/G1RCI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OS-9 family.|||Endoplasmic reticulum lumen|||Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation. http://togogenome.org/gene/61853:GALK1 ^@ http://purl.uniprot.org/uniprot/G1QLN1 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/61853:PNLIPRP3 ^@ http://purl.uniprot.org/uniprot/G1S321 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/61853:BTN1A1 ^@ http://purl.uniprot.org/uniprot/G1QT32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/61853:PPARG ^@ http://purl.uniprot.org/uniprot/A0A2I3H0K9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Cytoplasm|||Heterodimer with other nuclear receptors.|||Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.|||Nucleus http://togogenome.org/gene/61853:PSMC6 ^@ http://purl.uniprot.org/uniprot/G1RPW1 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/61853:MB21D2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HWL1 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/61853:ASB2 ^@ http://purl.uniprot.org/uniprot/G1S5Y7 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/61853:EFNA4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HET1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:ACAT2 ^@ http://purl.uniprot.org/uniprot/G1RK09 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/61853:TIMM10B ^@ http://purl.uniprot.org/uniprot/A0A2I3HXR2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/61853:TAGLN ^@ http://purl.uniprot.org/uniprot/G1R6Y3 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/61853:N6AMT1 ^@ http://purl.uniprot.org/uniprot/G1QRA3 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/61853:LOC100598207 ^@ http://purl.uniprot.org/uniprot/A0A2I3GR54 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/61853:LOC100591902 ^@ http://purl.uniprot.org/uniprot/G1QV55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/61853:TMSB15A ^@ http://purl.uniprot.org/uniprot/G1RTC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/61853:DZIP3 ^@ http://purl.uniprot.org/uniprot/G1QUZ2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:PLCB3 ^@ http://purl.uniprot.org/uniprot/G1QYG5 ^@ Cofactor|||Function ^@ Binds 1 Ca(2+) ion per subunit.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/61853:ST6GALNAC5 ^@ http://purl.uniprot.org/uniprot/G1RES3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/61853:PRSS16 ^@ http://purl.uniprot.org/uniprot/G1QWP6 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/61853:KPNA7 ^@ http://purl.uniprot.org/uniprot/G1RIW6 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/61853:LOC100597723 ^@ http://purl.uniprot.org/uniprot/G1RKK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/61853:ANO4 ^@ http://purl.uniprot.org/uniprot/A0A2I3G9L5|||http://purl.uniprot.org/uniprot/A0A2I3H7Y8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:KCNN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GPQ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:PTP4A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GRY3 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/61853:TRPM7 ^@ http://purl.uniprot.org/uniprot/G1R398 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.|||Membrane http://togogenome.org/gene/61853:TLR10 ^@ http://purl.uniprot.org/uniprot/G1S5C3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/61853:ACTA2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GZD3 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/61853:ATP5PF ^@ http://purl.uniprot.org/uniprot/G1QPR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ATPase subunit F6 family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/61853:COG3 ^@ http://purl.uniprot.org/uniprot/G1QPS2 ^@ Function|||Similarity ^@ Belongs to the COG3 family.|||Involved in ER-Golgi transport. http://togogenome.org/gene/61853:NDUFAF4 ^@ http://purl.uniprot.org/uniprot/G1RT50 ^@ Similarity|||Subunit ^@ Belongs to the NDUFAF4 family.|||Binds calmodulin. Interacts with NDUFAF3. http://togogenome.org/gene/61853:RPS4X ^@ http://purl.uniprot.org/uniprot/G1S927 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/61853:GPR4 ^@ http://purl.uniprot.org/uniprot/A0A2I3FQU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:APC ^@ http://purl.uniprot.org/uniprot/G1RLE9 ^@ Similarity ^@ Belongs to the adenomatous polyposis coli (APC) family. http://togogenome.org/gene/61853:SERPINA4 ^@ http://purl.uniprot.org/uniprot/G1S663 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/61853:PGP ^@ http://purl.uniprot.org/uniprot/A0A2I3GC63 ^@ Cofactor|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||Divalent metal ions. Mg(2+) is the most effective. http://togogenome.org/gene/61853:MRI1 ^@ http://purl.uniprot.org/uniprot/G1RRR0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:RIOK2 ^@ http://purl.uniprot.org/uniprot/G1RWI7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/61853:LALBA ^@ http://purl.uniprot.org/uniprot/G1S884 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase 22 family.|||Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins. http://togogenome.org/gene/61853:HS6ST1 ^@ http://purl.uniprot.org/uniprot/G1S1F9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/61853:ARMC1 ^@ http://purl.uniprot.org/uniprot/G1QUX6 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/61853:MC4R ^@ http://purl.uniprot.org/uniprot/G1SA07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). http://togogenome.org/gene/61853:MAK16 ^@ http://purl.uniprot.org/uniprot/A0A2I3GTD6 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/61853:NDUFS3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HIR7 ^@ Similarity ^@ Belongs to the complex I 30 kDa subunit family. http://togogenome.org/gene/61853:NIPAL3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GM75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/61853:MLH1 ^@ http://purl.uniprot.org/uniprot/G1QYL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||Nucleus http://togogenome.org/gene/61853:LOC100579776 ^@ http://purl.uniprot.org/uniprot/G1SCD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:IPO11 ^@ http://purl.uniprot.org/uniprot/G1QSI3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:ADH7 ^@ http://purl.uniprot.org/uniprot/A0A2I3HQY5|||http://purl.uniprot.org/uniprot/G1RUC3 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/61853:NUP133 ^@ http://purl.uniprot.org/uniprot/G1RWC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin Nup133 family.|||nuclear pore complex http://togogenome.org/gene/61853:CDH7 ^@ http://purl.uniprot.org/uniprot/G1RCP4 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:AACS ^@ http://purl.uniprot.org/uniprot/G1QQP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Converts acetoacetate to acetoacetyl-CoA in the cytosol.|||cytosol http://togogenome.org/gene/61853:PARP10 ^@ http://purl.uniprot.org/uniprot/G1QPS4 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/61853:NID1 ^@ http://purl.uniprot.org/uniprot/G1QSA1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/61853:AP1B1 ^@ http://purl.uniprot.org/uniprot/G1QRQ0 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/61853:PLSCR1 ^@ http://purl.uniprot.org/uniprot/G1QPF0 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/61853:GPR171 ^@ http://purl.uniprot.org/uniprot/G1SBA1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:GALNT3 ^@ http://purl.uniprot.org/uniprot/G1QSK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:WRN ^@ http://purl.uniprot.org/uniprot/A0A2I3HQW0 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/61853:FAM83A ^@ http://purl.uniprot.org/uniprot/A0A2I3GYT9|||http://purl.uniprot.org/uniprot/A0A2I3H2T9|||http://purl.uniprot.org/uniprot/G1QZM1 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/61853:LOC100604573 ^@ http://purl.uniprot.org/uniprot/G1RCQ5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nth/MutY family.|||Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.|||Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.|||Interacts with YBX1.|||Mitochondrion|||Nucleus http://togogenome.org/gene/61853:SLC39A9 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBV4|||http://purl.uniprot.org/uniprot/G1QLP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Cell membrane|||Membrane|||Mitochondrion|||Nucleus|||Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.|||perinuclear region|||trans-Golgi network membrane http://togogenome.org/gene/61853:DUSP3 ^@ http://purl.uniprot.org/uniprot/G1R137 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/61853:FAM91A1 ^@ http://purl.uniprot.org/uniprot/G1R034 ^@ Similarity ^@ Belongs to the FAM91 family. http://togogenome.org/gene/61853:APOA1 ^@ http://purl.uniprot.org/uniprot/G1R6X5 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/61853:TMEM41A ^@ http://purl.uniprot.org/uniprot/G1R3U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/61853:FAM8A1 ^@ http://purl.uniprot.org/uniprot/G1QK84 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:RFX3 ^@ http://purl.uniprot.org/uniprot/G1RC04 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:PRDM13 ^@ http://purl.uniprot.org/uniprot/G1RU74 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:APOA4 ^@ http://purl.uniprot.org/uniprot/G1R6X2 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/61853:POLR1D ^@ http://purl.uniprot.org/uniprot/G1QHN7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/61853:VTA1 ^@ http://purl.uniprot.org/uniprot/G1RYH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTA1 family.|||Cytoplasm|||Endosome membrane|||Membrane http://togogenome.org/gene/61853:POLR3B ^@ http://purl.uniprot.org/uniprot/A0A2I3H6C8 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/61853:EMC8 ^@ http://purl.uniprot.org/uniprot/A0A2I3HUR7|||http://purl.uniprot.org/uniprot/G1RKV5 ^@ Similarity ^@ Belongs to the EMC8/EMC9 family. http://togogenome.org/gene/61853:AP4M1 ^@ http://purl.uniprot.org/uniprot/G1RLB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal.|||Early endosome|||trans-Golgi network membrane http://togogenome.org/gene/61853:CCKAR ^@ http://purl.uniprot.org/uniprot/G1S4V8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/61853:KRT82 ^@ http://purl.uniprot.org/uniprot/G1S7R5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/61853:BOLA3 ^@ http://purl.uniprot.org/uniprot/A0A2I3FXI5 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/61853:HSD17B2 ^@ http://purl.uniprot.org/uniprot/G1RIG2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/61853:DCTN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GPD8|||http://purl.uniprot.org/uniprot/A0A2I3HN47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin 150 kDa subunit family.|||cell cortex|||cytoskeleton http://togogenome.org/gene/61853:TMEM41B ^@ http://purl.uniprot.org/uniprot/G1S719 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/61853:PARD6A ^@ http://purl.uniprot.org/uniprot/G1QY37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/61853:DEGS1 ^@ http://purl.uniprot.org/uniprot/G1RSN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:LOC100591599 ^@ http://purl.uniprot.org/uniprot/G1RKB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/61853:EVX1 ^@ http://purl.uniprot.org/uniprot/G1RYA8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:SPG21 ^@ http://purl.uniprot.org/uniprot/A0A2I3HT09 ^@ Function|||Subunit ^@ Interacts with CD4. Interacts with ALDH16A1.|||May play a role as a negative regulatory factor in CD4-dependent T-cell activation. http://togogenome.org/gene/61853:ND1 ^@ http://purl.uniprot.org/uniprot/E7EAE5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 1 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:GRB2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HAR1 ^@ Subcellular Location Annotation ^@ Endosome|||Golgi apparatus|||Nucleus http://togogenome.org/gene/61853:RPS15 ^@ http://purl.uniprot.org/uniprot/A0A2I3HTW0 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS19 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/61853:PTK6 ^@ http://purl.uniprot.org/uniprot/A0A2I3GG43 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/61853:RNF112 ^@ http://purl.uniprot.org/uniprot/G1RC12 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/61853:HSBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HE30 ^@ Similarity ^@ Belongs to the HSBP1 family. http://togogenome.org/gene/61853:EPS8L1 ^@ http://purl.uniprot.org/uniprot/G1RIL0 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/61853:CIAO2B ^@ http://purl.uniprot.org/uniprot/G1QVS8 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/61853:GUK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HAA0|||http://purl.uniprot.org/uniprot/A0A2I3HW40 ^@ Similarity ^@ Belongs to the guanylate kinase family. http://togogenome.org/gene/61853:LOC100582185 ^@ http://purl.uniprot.org/uniprot/G1SC00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:YWHAH ^@ http://purl.uniprot.org/uniprot/G1QXX5 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/61853:MAPRE1 ^@ http://purl.uniprot.org/uniprot/G1RFI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/61853:HSPA5 ^@ http://purl.uniprot.org/uniprot/G1S6C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Cell surface|||Endoplasmic reticulum lumen|||Melanosome http://togogenome.org/gene/61853:MRPL28 ^@ http://purl.uniprot.org/uniprot/A0A2I3GSU5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/61853:CREBL2 ^@ http://purl.uniprot.org/uniprot/G1QTR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. ATF subfamily.|||Nucleus http://togogenome.org/gene/61853:POLE2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HR68|||http://purl.uniprot.org/uniprot/G1RN11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase epsilon subunit B family.|||Nucleus|||Participates in DNA repair and in chromosomal DNA replication. http://togogenome.org/gene/61853:DGKA ^@ http://purl.uniprot.org/uniprot/G1S754 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic diacylglycerol kinase family.|||Monomer. http://togogenome.org/gene/61853:DGCR6L ^@ http://purl.uniprot.org/uniprot/A0A2I3G1L4 ^@ Similarity ^@ Belongs to the gonadal family. http://togogenome.org/gene/61853:PRKCB ^@ http://purl.uniprot.org/uniprot/A0A2I3HJQ3|||http://purl.uniprot.org/uniprot/G1RMP5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.|||Cytoplasm|||Membrane|||Nucleus http://togogenome.org/gene/61853:PIGP ^@ http://purl.uniprot.org/uniprot/G1QX25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGP family.|||Membrane|||Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. http://togogenome.org/gene/61853:FH ^@ http://purl.uniprot.org/uniprot/A0A2I3G9T5 ^@ Function|||Similarity ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.|||Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. http://togogenome.org/gene/61853:OCLN ^@ http://purl.uniprot.org/uniprot/G1QW88 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.|||Membrane|||tight junction http://togogenome.org/gene/61853:PLSCR4 ^@ http://purl.uniprot.org/uniprot/G1QYW2 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/61853:DNPEP ^@ http://purl.uniprot.org/uniprot/G1RE20 ^@ Similarity|||Subunit ^@ Belongs to the peptidase M18 family.|||Tetrahedron-shaped homododecamer built from six homodimers. http://togogenome.org/gene/61853:RFT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HVW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RFT1 family.|||May be involved in N-linked oligosaccharide assembly.|||Membrane http://togogenome.org/gene/61853:ATP6V1G2 ^@ http://purl.uniprot.org/uniprot/G1R2H1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/61853:FOXN1 ^@ http://purl.uniprot.org/uniprot/G1QPC4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:DTNA ^@ http://purl.uniprot.org/uniprot/G1R3A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dystrophin family. Dystrobrevin subfamily.|||Cytoplasm http://togogenome.org/gene/61853:KIF27 ^@ http://purl.uniprot.org/uniprot/G1QTC6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/61853:LOC100598295 ^@ http://purl.uniprot.org/uniprot/A0A2I3HN99 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/61853:PPIC ^@ http://purl.uniprot.org/uniprot/G1RN31 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/61853:PPA2 ^@ http://purl.uniprot.org/uniprot/G1RS63 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/61853:EDIL3 ^@ http://purl.uniprot.org/uniprot/G1RSR1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:NPLOC4 ^@ http://purl.uniprot.org/uniprot/A0A2I3H3D7 ^@ Similarity ^@ Belongs to the NPL4 family. http://togogenome.org/gene/61853:VDR ^@ http://purl.uniprot.org/uniprot/G1S8A8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:LAD1 ^@ http://purl.uniprot.org/uniprot/G1S8X6 ^@ Function|||Subcellular Location Annotation ^@ Anchoring filament protein which is a component of the basement membrane zone.|||basement membrane http://togogenome.org/gene/61853:LOC100602585 ^@ http://purl.uniprot.org/uniprot/G1R850 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/61853:UBE2T ^@ http://purl.uniprot.org/uniprot/G1S8Z3 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/61853:CXCR4 ^@ http://purl.uniprot.org/uniprot/G1RC63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell junction|||Cell membrane|||Early endosome|||Endosome|||Late endosome|||Lysosome|||Membrane http://togogenome.org/gene/61853:SCFD2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G7B4 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/61853:REEP1 ^@ http://purl.uniprot.org/uniprot/G1QR15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/61853:CCL22 ^@ http://purl.uniprot.org/uniprot/A0A2I3H9H8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/61853:MAB21L3 ^@ http://purl.uniprot.org/uniprot/G1QYT3 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/61853:FAM122A ^@ http://purl.uniprot.org/uniprot/A0A2I3G745 ^@ Similarity ^@ Belongs to the FAM122 family. http://togogenome.org/gene/61853:DACT1 ^@ http://purl.uniprot.org/uniprot/G1RSK5 ^@ Similarity ^@ Belongs to the dapper family. http://togogenome.org/gene/61853:AIMP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3H899 ^@ Subcellular Location Annotation ^@ Nucleus|||cytosol http://togogenome.org/gene/61853:LRP6 ^@ http://purl.uniprot.org/uniprot/G1QTL0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDLR family.|||Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.|||Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:CPT2 ^@ http://purl.uniprot.org/uniprot/G1S8L6 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/61853:MYOZ2 ^@ http://purl.uniprot.org/uniprot/G1RCM5 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/61853:ADAMTS16 ^@ http://purl.uniprot.org/uniprot/G1RKF9 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/61853:TMEM123 ^@ http://purl.uniprot.org/uniprot/G1R6A9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD164 family.|||Membrane http://togogenome.org/gene/61853:HSPA14 ^@ http://purl.uniprot.org/uniprot/G1RNC1|||http://purl.uniprot.org/uniprot/G1RNC2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.|||Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.|||cytosol http://togogenome.org/gene/61853:VPS52 ^@ http://purl.uniprot.org/uniprot/G1R551 ^@ Similarity ^@ Belongs to the VPS52 family. http://togogenome.org/gene/61853:SEC63 ^@ http://purl.uniprot.org/uniprot/G1RTB2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:AQP4 ^@ http://purl.uniprot.org/uniprot/G1R432 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/61853:RDX ^@ http://purl.uniprot.org/uniprot/G1R6L7 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/61853:RAF1 ^@ http://purl.uniprot.org/uniprot/G1QXT4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/61853:SLC28A3 ^@ http://purl.uniprot.org/uniprot/G1QU00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/61853:HSPB8 ^@ http://purl.uniprot.org/uniprot/G1QH72 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Cytoplasm|||Displays temperature-dependent chaperone activity.|||Nucleus http://togogenome.org/gene/61853:LIAS ^@ http://purl.uniprot.org/uniprot/A0A2I3GEA2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Mitochondrion http://togogenome.org/gene/61853:ATP6V0D2 ^@ http://purl.uniprot.org/uniprot/G1QLE0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/61853:OPTC ^@ http://purl.uniprot.org/uniprot/G1S919 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/61853:ERP29 ^@ http://purl.uniprot.org/uniprot/G1QGK9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Does not seem to be a disulfide isomerase.|||Endoplasmic reticulum lumen|||Homodimer.|||Melanosome http://togogenome.org/gene/61853:HECTD1 ^@ http://purl.uniprot.org/uniprot/G1S1H4 ^@ Function|||Similarity ^@ Belongs to the UPL family. K-HECT subfamily.|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. http://togogenome.org/gene/61853:PROX1 ^@ http://purl.uniprot.org/uniprot/G1RWC6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:SAP18 ^@ http://purl.uniprot.org/uniprot/G1QNB9 ^@ Similarity ^@ Belongs to the SAP18 family. http://togogenome.org/gene/61853:FZD10 ^@ http://purl.uniprot.org/uniprot/G1SAN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:HAAO ^@ http://purl.uniprot.org/uniprot/G1S437 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 3-HAO family.|||Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/61853:IL7 ^@ http://purl.uniprot.org/uniprot/A0A2I3G1Y2|||http://purl.uniprot.org/uniprot/A0A2I3GFK4|||http://purl.uniprot.org/uniprot/A0A2I3H3T9|||http://purl.uniprot.org/uniprot/G1QNL2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-7/IL-9 family.|||Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis.|||Interacts with IL7R and CSF2RG.|||Secreted http://togogenome.org/gene/61853:TRIM9 ^@ http://purl.uniprot.org/uniprot/A0A2I3HE46|||http://purl.uniprot.org/uniprot/G1RP32 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/61853:NSUN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GGT8 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/61853:SIM1 ^@ http://purl.uniprot.org/uniprot/G1RUD0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:LOC100589938 ^@ http://purl.uniprot.org/uniprot/G1RX19 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/61853:C8G ^@ http://purl.uniprot.org/uniprot/G1RBH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/61853:GJA10 ^@ http://purl.uniprot.org/uniprot/A0A654ICS2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/61853:LBR ^@ http://purl.uniprot.org/uniprot/A0A2I3H2J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/61853:RPL28 ^@ http://purl.uniprot.org/uniprot/A0A2I3H9Q1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL28 family. http://togogenome.org/gene/61853:TRHR ^@ http://purl.uniprot.org/uniprot/G1QVZ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/61853:RPN2 ^@ http://purl.uniprot.org/uniprot/G1R331 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SWP1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/61853:LOC100604897 ^@ http://purl.uniprot.org/uniprot/A0A2I3GIC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRB/QCR7 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:CCNA1 ^@ http://purl.uniprot.org/uniprot/G1S0F4 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily. http://togogenome.org/gene/61853:CCL20 ^@ http://purl.uniprot.org/uniprot/A0A2I3GWS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/61853:INTU ^@ http://purl.uniprot.org/uniprot/G1RT77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inturned family.|||Cell surface|||cilium basal body http://togogenome.org/gene/61853:CXCL8 ^@ http://purl.uniprot.org/uniprot/A0A2I3HR56 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Homodimer.|||Secreted http://togogenome.org/gene/61853:HNRNPR ^@ http://purl.uniprot.org/uniprot/A0A2I3FR57|||http://purl.uniprot.org/uniprot/G1RAR3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:PITX3 ^@ http://purl.uniprot.org/uniprot/G1RYF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/61853:LDHAL6B ^@ http://purl.uniprot.org/uniprot/G1SB71 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/61853:MED10 ^@ http://purl.uniprot.org/uniprot/A0A2I3H6E1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 10 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/61853:DNAJC2 ^@ http://purl.uniprot.org/uniprot/G1RDR8 ^@ Function|||Subcellular Location Annotation ^@ Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.|||Nucleus|||cytosol http://togogenome.org/gene/61853:BBS5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GGB3|||http://purl.uniprot.org/uniprot/G1QY66 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BBS5 family.|||Membrane|||Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.|||centriolar satellite|||cilium membrane http://togogenome.org/gene/61853:TNFRSF19 ^@ http://purl.uniprot.org/uniprot/A0A2I3HRK4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:ZDHHC9 ^@ http://purl.uniprot.org/uniprot/G1RZ33 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/61853:DAPK2 ^@ http://purl.uniprot.org/uniprot/A0A2I3FWL6|||http://purl.uniprot.org/uniprot/A0A2I3HB00 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:INSIG2 ^@ http://purl.uniprot.org/uniprot/G1RMF4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/61853:LOC100606669 ^@ http://purl.uniprot.org/uniprot/A0A2I3GFC1 ^@ Similarity ^@ Belongs to the COX20 family. http://togogenome.org/gene/61853:LOC101177997 ^@ http://purl.uniprot.org/uniprot/A0A2I3I0G1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/61853:COPS4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HLV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN4 family.|||Nucleus|||Vesicle|||synaptic vesicle http://togogenome.org/gene/61853:TRUB1 ^@ http://purl.uniprot.org/uniprot/G1S2U4 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/61853:SCML4 ^@ http://purl.uniprot.org/uniprot/G1RSZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/61853:MRPS5 ^@ http://purl.uniprot.org/uniprot/G1QGH5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/61853:PTPRN2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HF68|||http://purl.uniprot.org/uniprot/A0A2I3HH19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.|||Membrane|||secretory vesicle membrane http://togogenome.org/gene/61853:LOC100602515 ^@ http://purl.uniprot.org/uniprot/A0A2I3GME3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIb family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:LOC100588339 ^@ http://purl.uniprot.org/uniprot/A0A2I3HZ90|||http://purl.uniprot.org/uniprot/G1S496 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/61853:P2RX7 ^@ http://purl.uniprot.org/uniprot/G1S1N3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P2X receptor family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/61853:SCFD1 ^@ http://purl.uniprot.org/uniprot/G1S109 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/61853:SLC39A12 ^@ http://purl.uniprot.org/uniprot/A0A2I3H6G5|||http://purl.uniprot.org/uniprot/G1RQ43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Membrane http://togogenome.org/gene/61853:ATP11B ^@ http://purl.uniprot.org/uniprot/G1R210 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/61853:LIPG ^@ http://purl.uniprot.org/uniprot/G1RLF6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:ZNF449 ^@ http://purl.uniprot.org/uniprot/A0A2I3GWA3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:UCP1 ^@ http://purl.uniprot.org/uniprot/G1QZ98 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||May undergo ubiquitin-mediated proteasomal degradation.|||Membrane|||Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:CDH19 ^@ http://purl.uniprot.org/uniprot/A0A2I3G1F4 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:RMND1 ^@ http://purl.uniprot.org/uniprot/G1RZK4 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/61853:CHRNA6 ^@ http://purl.uniprot.org/uniprot/A0A2I3FXS2|||http://purl.uniprot.org/uniprot/G1RR34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/61853:LANCL3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GFS1|||http://purl.uniprot.org/uniprot/G1QJI0 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/61853:SDHAF2 ^@ http://purl.uniprot.org/uniprot/G1QQD7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SDHAF2 family.|||Interacts with SDHA within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. http://togogenome.org/gene/61853:TIMM17A ^@ http://purl.uniprot.org/uniprot/A0A2I3H6L2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:SQLE ^@ http://purl.uniprot.org/uniprot/G1R0I9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the squalene monooxygenase family.|||Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.|||Endoplasmic reticulum membrane http://togogenome.org/gene/61853:KCNJ1 ^@ http://purl.uniprot.org/uniprot/G1R7D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/61853:HMGB2 ^@ http://purl.uniprot.org/uniprot/G1R4I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/61853:DPPA5 ^@ http://purl.uniprot.org/uniprot/G1QKG6 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/61853:SUSD3 ^@ http://purl.uniprot.org/uniprot/G1S3H3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:DOCK2 ^@ http://purl.uniprot.org/uniprot/G1QZ10 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/61853:PRRT1 ^@ http://purl.uniprot.org/uniprot/G1R473 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/61853:GRM3 ^@ http://purl.uniprot.org/uniprot/G1RXY7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.|||Interacts with TAMALIN.|||Membrane http://togogenome.org/gene/61853:SLC24A2 ^@ http://purl.uniprot.org/uniprot/G1S6Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/61853:CDH2 ^@ http://purl.uniprot.org/uniprot/G1R423 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:TBX20 ^@ http://purl.uniprot.org/uniprot/G1QLX5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/61853:RAB3C ^@ http://purl.uniprot.org/uniprot/M3ZBG8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/61853:NMB ^@ http://purl.uniprot.org/uniprot/G1RKG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bombesin/neuromedin-B/ranatensin family.|||Secreted|||neuron projection http://togogenome.org/gene/61853:FBLN7 ^@ http://purl.uniprot.org/uniprot/G1QLT9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:DPAGT1 ^@ http://purl.uniprot.org/uniprot/G1R737 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family.|||Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:MSH2 ^@ http://purl.uniprot.org/uniprot/M3ZAA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutS family.|||Component of the post-replicative DNA mismatch repair system (MMR).|||Nucleus http://togogenome.org/gene/61853:ZIC2 ^@ http://purl.uniprot.org/uniprot/G1R8G5 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/61853:MED22 ^@ http://purl.uniprot.org/uniprot/G1RRK4 ^@ Function|||Subcellular Location Annotation ^@ Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/61853:TMEM258 ^@ http://purl.uniprot.org/uniprot/G1QS60 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST5 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/61853:LOC100601030 ^@ http://purl.uniprot.org/uniprot/G1RTC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/61853:GPM6B ^@ http://purl.uniprot.org/uniprot/A0A2I3GJY7|||http://purl.uniprot.org/uniprot/G1RDG0|||http://purl.uniprot.org/uniprot/M3ZAY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/61853:CENPA ^@ http://purl.uniprot.org/uniprot/A0A2I3FZD0|||http://purl.uniprot.org/uniprot/A0A2I3HX91 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/61853:ST3GAL6 ^@ http://purl.uniprot.org/uniprot/G1QPF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/61853:ZEB2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GQ48|||http://purl.uniprot.org/uniprot/G1RCR7 ^@ Similarity ^@ Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. http://togogenome.org/gene/61853:DMRTA1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HFG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/61853:CENPN ^@ http://purl.uniprot.org/uniprot/A0A2I3GLH8|||http://purl.uniprot.org/uniprot/A0A2I3GV52|||http://purl.uniprot.org/uniprot/A0A2I3H9C9|||http://purl.uniprot.org/uniprot/A0A2I3HGT8|||http://purl.uniprot.org/uniprot/G1RHM3 ^@ Similarity ^@ Belongs to the CENP-N/CHL4 family. http://togogenome.org/gene/61853:LTBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GYJ2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/61853:GBX2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GDG2|||http://purl.uniprot.org/uniprot/G1RI92 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:CTSE ^@ http://purl.uniprot.org/uniprot/G1QHW2 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/61853:BCAN ^@ http://purl.uniprot.org/uniprot/G1RQD0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aggrecan/versican proteoglycan family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/61853:CAMK4 ^@ http://purl.uniprot.org/uniprot/G1RL45 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:CETN2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GMP3 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/61853:NUP35 ^@ http://purl.uniprot.org/uniprot/A0A2I3FX38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Nup35 family.|||Functions as a component of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/61853:PDYN ^@ http://purl.uniprot.org/uniprot/G1RDL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin.|||Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Leumorphin has a typical opioid activity and may have anti-apoptotic effect.|||Secreted http://togogenome.org/gene/61853:PGM2 ^@ http://purl.uniprot.org/uniprot/G1S585 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/61853:CDA ^@ http://purl.uniprot.org/uniprot/G1R8W9 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/61853:CCT3 ^@ http://purl.uniprot.org/uniprot/G1RPV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/61853:TMEM265 ^@ http://purl.uniprot.org/uniprot/A0A2I3GUR7 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/61853:DCTN4 ^@ http://purl.uniprot.org/uniprot/A0A2I3I0C0|||http://purl.uniprot.org/uniprot/G1RHJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunit 4 family.|||cell cortex|||centrosome|||sarcomere|||stress fiber http://togogenome.org/gene/61853:CSTF1 ^@ http://purl.uniprot.org/uniprot/G1R5V2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:YARS2 ^@ http://purl.uniprot.org/uniprot/G1S3V3 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/61853:LOC100585631 ^@ http://purl.uniprot.org/uniprot/A0A2I3HM59 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/61853:CRYBB3 ^@ http://purl.uniprot.org/uniprot/G1R847 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/61853:HMBOX1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HX23 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:RGS4 ^@ http://purl.uniprot.org/uniprot/G1RX06 ^@ Function ^@ Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. http://togogenome.org/gene/61853:FGF10 ^@ http://purl.uniprot.org/uniprot/A0A2I3GCN2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/61853:RNF152 ^@ http://purl.uniprot.org/uniprot/A0A2I3HSF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNF152 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/61853:WDR35 ^@ http://purl.uniprot.org/uniprot/G1QP20|||http://purl.uniprot.org/uniprot/M3ZB26 ^@ Function|||Subcellular Location Annotation ^@ As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking.|||centrosome|||cilium basal body http://togogenome.org/gene/61853:LOC100586622 ^@ http://purl.uniprot.org/uniprot/G1RWZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/61853:CD47 ^@ http://purl.uniprot.org/uniprot/A0A2I3GCJ8|||http://purl.uniprot.org/uniprot/G1QTZ5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:ATP5IF1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H1P7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase inhibitor family.|||Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.|||Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.|||Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.|||Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.|||Mitochondrion http://togogenome.org/gene/61853:FAM126A ^@ http://purl.uniprot.org/uniprot/G1S4F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/61853:TXNL4B ^@ http://purl.uniprot.org/uniprot/G1R118 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/61853:FAM124A ^@ http://purl.uniprot.org/uniprot/A0A2I3HHG8 ^@ Similarity ^@ Belongs to the FAM124 family. http://togogenome.org/gene/61853:TSPYL2 ^@ http://purl.uniprot.org/uniprot/G1S1B9 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/61853:CLUL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H872|||http://purl.uniprot.org/uniprot/G1R564 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clusterin family.|||Secreted http://togogenome.org/gene/61853:TNFSF13B ^@ http://purl.uniprot.org/uniprot/A0A2I3GHB1 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/61853:XPO4 ^@ http://purl.uniprot.org/uniprot/G1QN10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Nucleus http://togogenome.org/gene/61853:MRPL11 ^@ http://purl.uniprot.org/uniprot/A0A2I3GW90 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/61853:HNRNPA2B1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H506|||http://purl.uniprot.org/uniprot/G1RY30 ^@ Subcellular Location Annotation ^@ Cytoplasmic granule http://togogenome.org/gene/61853:YAE1 ^@ http://purl.uniprot.org/uniprot/A0A2I3FPV6|||http://purl.uniprot.org/uniprot/A0A2I3GTD8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/61853:HOXA2 ^@ http://purl.uniprot.org/uniprot/G1RY83 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:NIPA1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H2Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/61853:DUPD1 ^@ http://purl.uniprot.org/uniprot/G1S4L5 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/61853:TMPRSS11E ^@ http://purl.uniprot.org/uniprot/G1RDF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/61853:P3H3 ^@ http://purl.uniprot.org/uniprot/G1QXR1 ^@ Similarity ^@ Belongs to the leprecan family. http://togogenome.org/gene/61853:PMF1 ^@ http://purl.uniprot.org/uniprot/G1RPB2 ^@ Subcellular Location Annotation ^@ Nucleus|||kinetochore http://togogenome.org/gene/61853:LOC100592631 ^@ http://purl.uniprot.org/uniprot/A0A2I3GIL3 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/61853:RPL37A ^@ http://purl.uniprot.org/uniprot/A0A2I3GET7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/61853:OPRK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H616|||http://purl.uniprot.org/uniprot/A0A2I3HAV1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.|||Interacts with NHERF1. Interacts with GABARAPL1.|||Membrane http://togogenome.org/gene/61853:CORO2A ^@ http://purl.uniprot.org/uniprot/G1S524 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/61853:OSBPL1A ^@ http://purl.uniprot.org/uniprot/G1R4D5 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/61853:SNX13 ^@ http://purl.uniprot.org/uniprot/G1S3P9 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/61853:DNAJB14 ^@ http://purl.uniprot.org/uniprot/A0A2I3H167 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:PTAR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H3C2 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family. http://togogenome.org/gene/61853:POLR2D ^@ http://purl.uniprot.org/uniprot/A0A2I3HS63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/61853:DLGAP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GR27|||http://purl.uniprot.org/uniprot/A0A2I3H2M6|||http://purl.uniprot.org/uniprot/G1R5F0 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/61853:GPAT4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GTI6 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/61853:SYNE4 ^@ http://purl.uniprot.org/uniprot/G1RLL8 ^@ Similarity ^@ Belongs to the nesprin family. http://togogenome.org/gene/61853:FTMT ^@ http://purl.uniprot.org/uniprot/G1SB68 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/61853:NUSAP1 ^@ http://purl.uniprot.org/uniprot/G1QTQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NUSAP family.|||Cytoplasm http://togogenome.org/gene/61853:MSMB ^@ http://purl.uniprot.org/uniprot/G1S1P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/61853:CENPC ^@ http://purl.uniprot.org/uniprot/G1RCV4 ^@ Similarity ^@ Belongs to the CENP-C/MIF2 family. http://togogenome.org/gene/61853:GPHN ^@ http://purl.uniprot.org/uniprot/G1QI49 ^@ Function|||Similarity ^@ Belongs to the MoeA family.|||Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.|||In the C-terminal section; belongs to the MoeA family.|||In the N-terminal section; belongs to the MoaB/Mog family. http://togogenome.org/gene/61853:C2H16orf70 ^@ http://purl.uniprot.org/uniprot/G1QWA0 ^@ Similarity ^@ Belongs to the PHAF1 family. http://togogenome.org/gene/61853:TRPC3 ^@ http://purl.uniprot.org/uniprot/G1RDX0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:RBP5 ^@ http://purl.uniprot.org/uniprot/G1QZ80 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/61853:EXOSC4 ^@ http://purl.uniprot.org/uniprot/G1RHK5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:PDGFRL ^@ http://purl.uniprot.org/uniprot/G1QQU9 ^@ Subunit ^@ Forms a complex composed of PDGFRL, TNK2 and GRB2. http://togogenome.org/gene/61853:SYT1 ^@ http://purl.uniprot.org/uniprot/G1QYR5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||synaptic vesicle membrane http://togogenome.org/gene/61853:GLIPR1 ^@ http://purl.uniprot.org/uniprot/G1QXE9 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/61853:BORCS5 ^@ http://purl.uniprot.org/uniprot/A0A2I3HR47|||http://purl.uniprot.org/uniprot/G1QTL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS5 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/61853:LAMTOR3 ^@ http://purl.uniprot.org/uniprot/G1RTM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR3 family.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/61853:BMP15 ^@ http://purl.uniprot.org/uniprot/G1R9Q9 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/61853:SLCO1B3 ^@ http://purl.uniprot.org/uniprot/G1QXP1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:CHRNA10 ^@ http://purl.uniprot.org/uniprot/G1S642 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/61853:SEC31A ^@ http://purl.uniprot.org/uniprot/A0A2I3HES2|||http://purl.uniprot.org/uniprot/A0A2I3HR75|||http://purl.uniprot.org/uniprot/A0A2I3I053|||http://purl.uniprot.org/uniprot/G1RCD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC31 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/61853:HIBADH ^@ http://purl.uniprot.org/uniprot/G1RYC1 ^@ Similarity ^@ Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily. http://togogenome.org/gene/61853:RRAGB ^@ http://purl.uniprot.org/uniprot/A0A2I3GMS9|||http://purl.uniprot.org/uniprot/G1S2U1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/61853:SLC24A4 ^@ http://purl.uniprot.org/uniprot/G1S5Q0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/61853:OPN5 ^@ http://purl.uniprot.org/uniprot/G1QVX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/61853:TNFAIP1 ^@ http://purl.uniprot.org/uniprot/G1QN25 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/61853:SLC35D2 ^@ http://purl.uniprot.org/uniprot/G1S4H4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:CFAP300 ^@ http://purl.uniprot.org/uniprot/G1R6A3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP300 family.|||Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.|||Cytoplasm http://togogenome.org/gene/61853:CTNNA3 ^@ http://purl.uniprot.org/uniprot/G1RN12 ^@ Similarity ^@ Belongs to the vinculin/alpha-catenin family. http://togogenome.org/gene/61853:CA7 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBU9|||http://purl.uniprot.org/uniprot/A0A2I3HLD6 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/61853:LOC101176156 ^@ http://purl.uniprot.org/uniprot/A0A2I3GJR7 ^@ Similarity ^@ Belongs to the cornifin (SPRR) family. http://togogenome.org/gene/61853:F9 ^@ http://purl.uniprot.org/uniprot/G1QRY9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:AHSA1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GPB5 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/61853:TMPO ^@ http://purl.uniprot.org/uniprot/A0A2I3FYT4|||http://purl.uniprot.org/uniprot/A0A2I3HVG4|||http://purl.uniprot.org/uniprot/G1R1Z5 ^@ Similarity ^@ Belongs to the LEM family. http://togogenome.org/gene/61853:RABGGTB ^@ http://purl.uniprot.org/uniprot/G1REP9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX. http://togogenome.org/gene/61853:RAD21 ^@ http://purl.uniprot.org/uniprot/G1QY51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/61853:MARS1 ^@ http://purl.uniprot.org/uniprot/G1S689 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/61853:FABP4 ^@ http://purl.uniprot.org/uniprot/G1QQ09 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/61853:TNFSF11 ^@ http://purl.uniprot.org/uniprot/A0A2I3FWG4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Homotrimer.|||Membrane|||Secreted http://togogenome.org/gene/61853:RPS14 ^@ http://purl.uniprot.org/uniprot/A0A2I3I0G1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/61853:WDR55 ^@ http://purl.uniprot.org/uniprot/A0A2I3HIW3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR55 family.|||Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.|||nucleolus http://togogenome.org/gene/61853:CDCA7 ^@ http://purl.uniprot.org/uniprot/A0A2I3H6C9|||http://purl.uniprot.org/uniprot/G1R1G1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/61853:TMEM126B ^@ http://purl.uniprot.org/uniprot/A0A2I3H6I0|||http://purl.uniprot.org/uniprot/G1S330 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:LIG4 ^@ http://purl.uniprot.org/uniprot/G1R8S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/61853:LDHAL6A ^@ http://purl.uniprot.org/uniprot/G1S7V3 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/61853:CDH18 ^@ http://purl.uniprot.org/uniprot/G1RMU3 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:CFAP97D1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HCQ5 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/61853:MPZ ^@ http://purl.uniprot.org/uniprot/G1RW13 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the myelin P0 protein family.|||Cell membrane|||Homodimer and homotetramer.|||Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.|||Membrane http://togogenome.org/gene/61853:PUS3 ^@ http://purl.uniprot.org/uniprot/G1R7A9 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/61853:ATAT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GXS9|||http://purl.uniprot.org/uniprot/A0A2I3HLC2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autoacetylation strongly increases tubulin acetylation.|||Belongs to the acetyltransferase ATAT1 family.|||Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.|||Cytoplasm|||Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.|||axon|||clathrin-coated pit|||cytoskeleton|||focal adhesion|||spindle http://togogenome.org/gene/61853:UBE3D ^@ http://purl.uniprot.org/uniprot/G1RPW0 ^@ Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. http://togogenome.org/gene/61853:SCGB1A1 ^@ http://purl.uniprot.org/uniprot/G1QTG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the secretoglobin family.|||Secreted http://togogenome.org/gene/61853:TIRAP ^@ http://purl.uniprot.org/uniprot/A0A2I3HKD7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response.|||Cell membrane|||Cytoplasm|||Homodimer.|||Membrane http://togogenome.org/gene/61853:ERBB4 ^@ http://purl.uniprot.org/uniprot/G1R6F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/61853:GNAI1 ^@ http://purl.uniprot.org/uniprot/G1REQ5 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/61853:GRAMD1C ^@ http://purl.uniprot.org/uniprot/G1QXN3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:PDP1 ^@ http://purl.uniprot.org/uniprot/G1QRM9 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/61853:LOC100583040 ^@ http://purl.uniprot.org/uniprot/G1S2P6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/61853:PLPPR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G445 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/61853:MED27 ^@ http://purl.uniprot.org/uniprot/G1RQR3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 27 family.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/61853:LOC100595279 ^@ http://purl.uniprot.org/uniprot/A0A2I3GR51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the p22phox family.|||Cell membrane|||Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.|||Membrane http://togogenome.org/gene/61853:CMBL ^@ http://purl.uniprot.org/uniprot/G1RLJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/61853:PLAUR ^@ http://purl.uniprot.org/uniprot/A0A2I3G334|||http://purl.uniprot.org/uniprot/G1QMB3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:WNK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GCL4|||http://purl.uniprot.org/uniprot/A0A2I3HNY6|||http://purl.uniprot.org/uniprot/A0A2I3HU96|||http://purl.uniprot.org/uniprot/G1QPM5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/61853:CDC42SE1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H9L0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.|||Membrane|||Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.|||cytoskeleton http://togogenome.org/gene/61853:PRC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H8N1|||http://purl.uniprot.org/uniprot/G1RNU0 ^@ Similarity ^@ Belongs to the MAP65/ASE1 family. http://togogenome.org/gene/61853:GORAB ^@ http://purl.uniprot.org/uniprot/G1RYP2 ^@ Similarity ^@ Belongs to the GORAB family. http://togogenome.org/gene/61853:ATG5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GG35|||http://purl.uniprot.org/uniprot/G1RSA1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG5 family.|||Conjugated with ATG12.|||Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.|||May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.|||Preautophagosomal structure membrane http://togogenome.org/gene/61853:ATP6V1H ^@ http://purl.uniprot.org/uniprot/A0A2I3H1J4|||http://purl.uniprot.org/uniprot/G1QJL0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/61853:LOC100601581 ^@ http://purl.uniprot.org/uniprot/A0A2I3FXW2|||http://purl.uniprot.org/uniprot/G1RVF6 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/61853:LOC100587151 ^@ http://purl.uniprot.org/uniprot/G1SBF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:LOC100579841 ^@ http://purl.uniprot.org/uniprot/G1QZQ2 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/61853:ANAPC5 ^@ http://purl.uniprot.org/uniprot/G1S249 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC5 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||spindle http://togogenome.org/gene/61853:LOC100595614 ^@ http://purl.uniprot.org/uniprot/G1S9R8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:FOXB1 ^@ http://purl.uniprot.org/uniprot/G1RLU0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:C8H9orf78 ^@ http://purl.uniprot.org/uniprot/G1S7D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TLS1 family.|||Nucleus http://togogenome.org/gene/61853:ACADM ^@ http://purl.uniprot.org/uniprot/A0A2I3HGH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/61853:WNT2 ^@ http://purl.uniprot.org/uniprot/Q07DX7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).|||Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.|||Secreted|||extracellular matrix http://togogenome.org/gene/61853:ANTXR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HS32|||http://purl.uniprot.org/uniprot/G1RGD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATR family.|||Membrane http://togogenome.org/gene/61853:LOC100579706 ^@ http://purl.uniprot.org/uniprot/M3ZAH2 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/61853:LRRC51 ^@ http://purl.uniprot.org/uniprot/A0A2I3GEM2|||http://purl.uniprot.org/uniprot/A0A2I3HLE0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:AP1M1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GRJ3|||http://purl.uniprot.org/uniprot/G1R091 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Golgi apparatus|||Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.|||clathrin-coated vesicle membrane http://togogenome.org/gene/61853:METTL8 ^@ http://purl.uniprot.org/uniprot/G1QZZ4 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/61853:MMP1 ^@ http://purl.uniprot.org/uniprot/G1R6C9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/61853:ADAM22 ^@ http://purl.uniprot.org/uniprot/A0A2I3GQ97|||http://purl.uniprot.org/uniprot/G1RYK9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:IRAK1BP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GRK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRAK1BP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:TATDN1 ^@ http://purl.uniprot.org/uniprot/G1R0A8 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/61853:TMEM168 ^@ http://purl.uniprot.org/uniprot/G1RKQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM168 family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/61853:IL5 ^@ http://purl.uniprot.org/uniprot/G1RQD7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-5 family.|||Homodimer; disulfide-linked.|||Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.|||Secreted http://togogenome.org/gene/61853:GSTM2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GHY1 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Mu family.|||Homodimer. http://togogenome.org/gene/61853:COPS7A ^@ http://purl.uniprot.org/uniprot/G1QX83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:LOC100603119 ^@ http://purl.uniprot.org/uniprot/A0A2I3HT40 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/61853:POT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GN50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the telombin family.|||Nucleus|||telomere http://togogenome.org/gene/61853:LCOR ^@ http://purl.uniprot.org/uniprot/A0A2I3HA63 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:IZUMO2 ^@ http://purl.uniprot.org/uniprot/G1R0H4 ^@ Similarity ^@ Belongs to the Izumo family. http://togogenome.org/gene/61853:LOC100581891 ^@ http://purl.uniprot.org/uniprot/A0A2I3GM37 ^@ Similarity ^@ Belongs to the cornifin (SPRR) family. http://togogenome.org/gene/61853:EMC9 ^@ http://purl.uniprot.org/uniprot/A0A2I3HXT1 ^@ Similarity ^@ Belongs to the EMC8/EMC9 family. http://togogenome.org/gene/61853:CCDC85B ^@ http://purl.uniprot.org/uniprot/A0A2I3HE63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC85 family.|||adherens junction http://togogenome.org/gene/61853:MDFI ^@ http://purl.uniprot.org/uniprot/A0A2I3H3Z7|||http://purl.uniprot.org/uniprot/G1QYG0 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/61853:ADPRHL1 ^@ http://purl.uniprot.org/uniprot/G1QJ39 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/61853:FECH ^@ http://purl.uniprot.org/uniprot/G1R9G4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferrochelatase family.|||Catalyzes the ferrous insertion into protoporphyrin IX.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:C2H5orf30 ^@ http://purl.uniprot.org/uniprot/G1RK31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UNC119-binding protein family.|||Cytoplasm|||cilium http://togogenome.org/gene/61853:ASPDH ^@ http://purl.uniprot.org/uniprot/G1R103 ^@ Similarity ^@ Belongs to the L-aspartate dehydrogenase family. http://togogenome.org/gene/61853:NIFK ^@ http://purl.uniprot.org/uniprot/G1QKG8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/61853:FAM229A ^@ http://purl.uniprot.org/uniprot/G1QQG0 ^@ Similarity ^@ Belongs to the FAM229 family. http://togogenome.org/gene/61853:ITGA2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HG50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/61853:MAPKAPK3 ^@ http://purl.uniprot.org/uniprot/G1R5T7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:ETHE1 ^@ http://purl.uniprot.org/uniprot/G1QL68 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/61853:LECT2 ^@ http://purl.uniprot.org/uniprot/G1RA57 ^@ Similarity ^@ Belongs to the LECT2/MIM-1 family. http://togogenome.org/gene/61853:LOC100591962 ^@ http://purl.uniprot.org/uniprot/A0A2I3GFS3|||http://purl.uniprot.org/uniprot/G1RIS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/61853:EIF4A2 ^@ http://purl.uniprot.org/uniprot/G1R4H7 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/61853:LOC100591567 ^@ http://purl.uniprot.org/uniprot/G1S986 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:AGA ^@ http://purl.uniprot.org/uniprot/G1S4J8 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/61853:LOC100602615 ^@ http://purl.uniprot.org/uniprot/A0A2I3HSQ6 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/61853:SOD1 ^@ http://purl.uniprot.org/uniprot/G1QTN4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/61853:C6H15orf40 ^@ http://purl.uniprot.org/uniprot/A0A2I3GAC6 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/61853:MRPL53 ^@ http://purl.uniprot.org/uniprot/A0A2I3G879 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL53 family.|||Mitochondrion http://togogenome.org/gene/61853:TEC ^@ http://purl.uniprot.org/uniprot/G1S6G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cytoplasm http://togogenome.org/gene/61853:RSPO3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HPC6 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/61853:HIF1A ^@ http://purl.uniprot.org/uniprot/A0A2I3HYP2|||http://purl.uniprot.org/uniprot/G1RUP5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus speckle http://togogenome.org/gene/61853:CTH ^@ http://purl.uniprot.org/uniprot/G1RE31 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/61853:ACADS ^@ http://purl.uniprot.org/uniprot/G1S1B1 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/61853:AK2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GCV1|||http://purl.uniprot.org/uniprot/G1QSG9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK2 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Mitochondrion intermembrane space|||Monomer. http://togogenome.org/gene/61853:LOC100586578 ^@ http://purl.uniprot.org/uniprot/A0A2I3GB94 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/61853:IRF9 ^@ http://purl.uniprot.org/uniprot/G1RZ88 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:RPE ^@ http://purl.uniprot.org/uniprot/A0A2I3HGS3|||http://purl.uniprot.org/uniprot/A0A2I3HSC9 ^@ Cofactor|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/61853:RPL24 ^@ http://purl.uniprot.org/uniprot/A0A2I3H3Q6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/61853:FCF1 ^@ http://purl.uniprot.org/uniprot/G1S2P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP23/FCF1 family. FCF1 subfamily.|||nucleolus http://togogenome.org/gene/61853:ID3 ^@ http://purl.uniprot.org/uniprot/A0A2I3G7V5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:LOC100581084 ^@ http://purl.uniprot.org/uniprot/A0A2I3GN60 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/61853:MINAR1 ^@ http://purl.uniprot.org/uniprot/G1RHC9 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/61853:USP27X ^@ http://purl.uniprot.org/uniprot/A0A2I3GLY5 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/61853:SCPEP1 ^@ http://purl.uniprot.org/uniprot/G1R9B9 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/61853:GFM1 ^@ http://purl.uniprot.org/uniprot/G1QVZ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.|||Mitochondrion http://togogenome.org/gene/61853:FLVCR1 ^@ http://purl.uniprot.org/uniprot/G1RWS7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:SLC26A4 ^@ http://purl.uniprot.org/uniprot/G1RBK1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane|||Sodium-independent transporter of chloride and iodide. http://togogenome.org/gene/61853:DDX31 ^@ http://purl.uniprot.org/uniprot/G1RR00|||http://purl.uniprot.org/uniprot/M3Z985 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/61853:UCHL3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GN22 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/61853:PI4K2B ^@ http://purl.uniprot.org/uniprot/G1S4I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.|||Membrane http://togogenome.org/gene/61853:LOC100599179 ^@ http://purl.uniprot.org/uniprot/G1RGZ2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/61853:LOC100596577 ^@ http://purl.uniprot.org/uniprot/G1SCC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:HABP2 ^@ http://purl.uniprot.org/uniprot/G1S1G6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:ADHFE1 ^@ http://purl.uniprot.org/uniprot/G1RIG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.|||Mitochondrion http://togogenome.org/gene/61853:GRHL1 ^@ http://purl.uniprot.org/uniprot/G1RTK9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:LYG2 ^@ http://purl.uniprot.org/uniprot/G1QNT8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 23 family. http://togogenome.org/gene/61853:SATB1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HB41|||http://purl.uniprot.org/uniprot/G1QJI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/61853:CARM1 ^@ http://purl.uniprot.org/uniprot/G1RP73 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:HLCS ^@ http://purl.uniprot.org/uniprot/G1QWZ1 ^@ Similarity ^@ Belongs to the biotin--protein ligase family. http://togogenome.org/gene/61853:CLDN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HKP3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the claudin family.|||Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/61853:VNN1 ^@ http://purl.uniprot.org/uniprot/G1RWW1 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/61853:MYO3B ^@ http://purl.uniprot.org/uniprot/G1QZ91|||http://purl.uniprot.org/uniprot/G1QZ94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||cytoskeleton http://togogenome.org/gene/61853:E2F8 ^@ http://purl.uniprot.org/uniprot/G1S7Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/61853:CENPQ ^@ http://purl.uniprot.org/uniprot/A0A2I3HSF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-Q/OKP1 family.|||Nucleus http://togogenome.org/gene/61853:AMELX ^@ http://purl.uniprot.org/uniprot/A0A2I3HHT8|||http://purl.uniprot.org/uniprot/A0A2I3HX96|||http://purl.uniprot.org/uniprot/G1RCS3 ^@ Similarity ^@ Belongs to the amelogenin family. http://togogenome.org/gene/61853:STK17A ^@ http://purl.uniprot.org/uniprot/G1QSU4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:PTH2 ^@ http://purl.uniprot.org/uniprot/G1QZ33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parathyroid hormone family.|||Secreted http://togogenome.org/gene/61853:ST14 ^@ http://purl.uniprot.org/uniprot/G1R7E4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S1 family.|||Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.|||Interacts with CDCP1. May interact with TMEFF1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:PTK7 ^@ http://purl.uniprot.org/uniprot/A0A2I3HRK6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:GPAT3 ^@ http://purl.uniprot.org/uniprot/A0A2I3G5Z7 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/61853:TSHZ2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HXZ5|||http://purl.uniprot.org/uniprot/G1R5T2 ^@ Similarity ^@ Belongs to the teashirt C2H2-type zinc-finger protein family. http://togogenome.org/gene/61853:SUPT3H ^@ http://purl.uniprot.org/uniprot/A0A2I3HJM7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:TMEM229B ^@ http://purl.uniprot.org/uniprot/A0A2I3HZP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM229 family.|||Membrane http://togogenome.org/gene/61853:SESN3 ^@ http://purl.uniprot.org/uniprot/G1R663 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/61853:TPM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GPN2|||http://purl.uniprot.org/uniprot/A0A2I3GU60|||http://purl.uniprot.org/uniprot/A0A2I3H4R9|||http://purl.uniprot.org/uniprot/A0A2I3H6A4|||http://purl.uniprot.org/uniprot/A0A2I3HFZ5|||http://purl.uniprot.org/uniprot/A0A2I3HVE9|||http://purl.uniprot.org/uniprot/G1RNK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/61853:DMGDH ^@ http://purl.uniprot.org/uniprot/G1RQP4 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/61853:DGKG ^@ http://purl.uniprot.org/uniprot/G1R446 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/61853:GTF2E1 ^@ http://purl.uniprot.org/uniprot/G1QZ47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIE alpha subunit family.|||Nucleus|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. http://togogenome.org/gene/61853:PLA2G2E ^@ http://purl.uniprot.org/uniprot/G1R8S6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/61853:LOC100588080 ^@ http://purl.uniprot.org/uniprot/G1QQ94 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/61853:IL17RB ^@ http://purl.uniprot.org/uniprot/G1R6J8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:ROR1 ^@ http://purl.uniprot.org/uniprot/G1RYM7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:LOC100600090 ^@ http://purl.uniprot.org/uniprot/G1RGS9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/61853:GPR107 ^@ http://purl.uniprot.org/uniprot/G1S7G3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:FGFR1OP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3FZT3|||http://purl.uniprot.org/uniprot/G1R028 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/61853:DDX4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GHS8|||http://purl.uniprot.org/uniprot/A0A2I3GUR4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/61853:AP3S1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GWB8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Membrane|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. http://togogenome.org/gene/61853:CSTF3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GDW6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:DARS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GF22 ^@ Function|||Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. http://togogenome.org/gene/61853:EXOSC5 ^@ http://purl.uniprot.org/uniprot/G1RTP2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:LOC100593952 ^@ http://purl.uniprot.org/uniprot/G1RQC5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/61853:TMEM225 ^@ http://purl.uniprot.org/uniprot/G1R773 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:PPP4R3A ^@ http://purl.uniprot.org/uniprot/G1S5G6 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/61853:CHST11 ^@ http://purl.uniprot.org/uniprot/M3ZAP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:KCNMB2 ^@ http://purl.uniprot.org/uniprot/G1R0X5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/61853:FGF22 ^@ http://purl.uniprot.org/uniprot/G1QJ57 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/61853:B3GALT2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HLP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:LOC100598671 ^@ http://purl.uniprot.org/uniprot/G1S9R7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:RRP7A ^@ http://purl.uniprot.org/uniprot/A0A2I3H015 ^@ Similarity ^@ Belongs to the RRP7 family. http://togogenome.org/gene/61853:CDC42EP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GWI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system|||Probably involved in the organization of the actin cytoskeleton.|||cytoskeleton http://togogenome.org/gene/61853:SNAP25 ^@ http://purl.uniprot.org/uniprot/A0A2I3FZK1|||http://purl.uniprot.org/uniprot/G1RWF4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Membrane|||Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.|||Photoreceptor inner segment|||synaptosome|||t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. http://togogenome.org/gene/61853:SEC11C ^@ http://purl.uniprot.org/uniprot/A0A2I3H7P2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:CDK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G9U5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:GABRA1 ^@ http://purl.uniprot.org/uniprot/G1QX94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/61853:IRGM ^@ http://purl.uniprot.org/uniprot/C3UZU9 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. http://togogenome.org/gene/61853:RBX1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GXJ6 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/61853:KIFBP ^@ http://purl.uniprot.org/uniprot/G1RLH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KIF-binding protein family.|||cytoskeleton http://togogenome.org/gene/61853:ANAPC15 ^@ http://purl.uniprot.org/uniprot/A0A2I3H8X8 ^@ Similarity ^@ Belongs to the APC15 family. http://togogenome.org/gene/61853:AP3M2 ^@ http://purl.uniprot.org/uniprot/G1RQJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus http://togogenome.org/gene/61853:RPS3A ^@ http://purl.uniprot.org/uniprot/G1R1G8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.|||Cytoplasm|||May play a role during erythropoiesis through regulation of transcription factor DDIT3.|||Nucleus|||nucleolus http://togogenome.org/gene/61853:SLC1A7 ^@ http://purl.uniprot.org/uniprot/A0A2I3H9H4|||http://purl.uniprot.org/uniprot/A0A2I3HQ96|||http://purl.uniprot.org/uniprot/G1S8L7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:HASPIN ^@ http://purl.uniprot.org/uniprot/G1SB20 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/61853:HOXC4 ^@ http://purl.uniprot.org/uniprot/G1S7G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/61853:INSL6 ^@ http://purl.uniprot.org/uniprot/G1RCJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||May have a role in sperm development and fertilization.|||Secreted http://togogenome.org/gene/61853:SORCS3 ^@ http://purl.uniprot.org/uniprot/G1RZJ4 ^@ Similarity ^@ Belongs to the VPS10-related sortilin family. SORCS subfamily. http://togogenome.org/gene/61853:MLN ^@ http://purl.uniprot.org/uniprot/G1RAS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the motilin family.|||Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.|||Secreted http://togogenome.org/gene/61853:DPY19L3 ^@ http://purl.uniprot.org/uniprot/G1R7T2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/61853:EPN2 ^@ http://purl.uniprot.org/uniprot/G1RBQ9 ^@ Similarity ^@ Belongs to the epsin family. http://togogenome.org/gene/61853:USE1 ^@ http://purl.uniprot.org/uniprot/G1R106 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the USE1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:VANGL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H432 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:NAA10 ^@ http://purl.uniprot.org/uniprot/A0A2I3HJQ8 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/61853:AQP11 ^@ http://purl.uniprot.org/uniprot/G1S435 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.|||Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.|||Membrane http://togogenome.org/gene/61853:ATP2C1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GKM3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:RAB9A ^@ http://purl.uniprot.org/uniprot/A0A2I3G0W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||phagosome membrane http://togogenome.org/gene/61853:MAP2K1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GXI0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:GAB3 ^@ http://purl.uniprot.org/uniprot/G1RVW5 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/61853:ENTPD5 ^@ http://purl.uniprot.org/uniprot/G1S264 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/61853:MAP1LC3B ^@ http://purl.uniprot.org/uniprot/G1RLA3 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/61853:SDC4 ^@ http://purl.uniprot.org/uniprot/G1R4N6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/61853:EVA1B ^@ http://purl.uniprot.org/uniprot/A0A2I3HMD7 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/61853:TSN ^@ http://purl.uniprot.org/uniprot/A0A2I3H750 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the translin family.|||DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.|||Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.|||Nucleus|||Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring. http://togogenome.org/gene/61853:MCM6 ^@ http://purl.uniprot.org/uniprot/G1RBX3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/61853:SSTR3 ^@ http://purl.uniprot.org/uniprot/G1RXG6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:CTSS ^@ http://purl.uniprot.org/uniprot/G1RFY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/61853:RRH ^@ http://purl.uniprot.org/uniprot/G1S3L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/61853:SYNPR ^@ http://purl.uniprot.org/uniprot/A0A2I3H8L4|||http://purl.uniprot.org/uniprot/G1RM18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/61853:OTP ^@ http://purl.uniprot.org/uniprot/G1RQD1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:COQ8B ^@ http://purl.uniprot.org/uniprot/G1RUL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family.|||Membrane http://togogenome.org/gene/61853:LOC101179385 ^@ http://purl.uniprot.org/uniprot/G1RHF3 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/61853:RPL27A ^@ http://purl.uniprot.org/uniprot/G1S6Y9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/61853:LHX2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G8Y4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:RGS9BP ^@ http://purl.uniprot.org/uniprot/A0A2I3HFA2 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/61853:DPYSL5 ^@ http://purl.uniprot.org/uniprot/G1QQ70 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/61853:RNF175 ^@ http://purl.uniprot.org/uniprot/G1R235 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:EXOSC1 ^@ http://purl.uniprot.org/uniprot/G1RUD6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:EDN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HE82|||http://purl.uniprot.org/uniprot/A0A2I3HXY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/61853:XRN2 ^@ http://purl.uniprot.org/uniprot/G1RG93 ^@ Function|||Similarity ^@ Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.|||Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. http://togogenome.org/gene/61853:MSX2 ^@ http://purl.uniprot.org/uniprot/G1QI88 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:GFRA1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HH16 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.|||Belongs to the GDNFR family.|||Cell membrane|||Membrane|||Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. http://togogenome.org/gene/61853:RORB ^@ http://purl.uniprot.org/uniprot/G1QLC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/61853:UPK1A ^@ http://purl.uniprot.org/uniprot/G1RKG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/61853:SOD2 ^@ http://purl.uniprot.org/uniprot/G1RJQ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems.|||Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.|||Homotetramer.|||Mitochondrion matrix http://togogenome.org/gene/61853:FAM49B ^@ http://purl.uniprot.org/uniprot/G1R0Q1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CYRI family.|||Interacts with RAC1 (GTP-bound form preferentially).|||Membrane http://togogenome.org/gene/61853:ALKAL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GYA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALKAL family.|||Secreted http://togogenome.org/gene/61853:PARP11 ^@ http://purl.uniprot.org/uniprot/A0A2I3GCT8|||http://purl.uniprot.org/uniprot/A0A2I3H8T0 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/61853:LOC100594144 ^@ http://purl.uniprot.org/uniprot/A0A2I3GWH1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:TUBGCP4 ^@ http://purl.uniprot.org/uniprot/G1QYN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/61853:CDKN1B ^@ http://purl.uniprot.org/uniprot/G1QTS5 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/61853:FGF21 ^@ http://purl.uniprot.org/uniprot/G1QXG8 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/61853:SEM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G278|||http://purl.uniprot.org/uniprot/G1S1L9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DSS1/SEM1 family.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.|||Nucleus http://togogenome.org/gene/61853:MIS12 ^@ http://purl.uniprot.org/uniprot/G1S9G9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mis12 family.|||Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.|||kinetochore http://togogenome.org/gene/61853:LOC100600963 ^@ http://purl.uniprot.org/uniprot/G1SC61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/61853:YIPF6 ^@ http://purl.uniprot.org/uniprot/A0A2I3HW51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:GPBP1 ^@ http://purl.uniprot.org/uniprot/G1QPW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/61853:LOC100606517 ^@ http://purl.uniprot.org/uniprot/G1SBV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:ME1 ^@ http://purl.uniprot.org/uniprot/G1RQ93 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/61853:CLDN22 ^@ http://purl.uniprot.org/uniprot/G1SB40 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/61853:CEP162 ^@ http://purl.uniprot.org/uniprot/A0A2I3HYL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP162 family.|||centriole http://togogenome.org/gene/61853:NPPB ^@ http://purl.uniprot.org/uniprot/G1RF43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Secreted http://togogenome.org/gene/61853:KDR ^@ http://purl.uniprot.org/uniprot/G1RAQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:BRINP2 ^@ http://purl.uniprot.org/uniprot/G1RZY2 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/61853:DEFA5 ^@ http://purl.uniprot.org/uniprot/G1RY43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-defensin family.|||Secreted http://togogenome.org/gene/61853:SESN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H4T0|||http://purl.uniprot.org/uniprot/G1RPL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/61853:SUCLG2 ^@ http://purl.uniprot.org/uniprot/G1R7K9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.|||Binds 1 Mg(2+) ion per subunit.|||GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.|||Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.|||Mitochondrion http://togogenome.org/gene/61853:MFF ^@ http://purl.uniprot.org/uniprot/A0A2I3GG28|||http://purl.uniprot.org/uniprot/A0A2I3GLD1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tango11 family.|||Membrane|||Mitochondrion outer membrane|||Peroxisome|||Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.|||synaptic vesicle http://togogenome.org/gene/61853:ACTR6 ^@ http://purl.uniprot.org/uniprot/A0A2I3HU17 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/61853:C4BPB ^@ http://purl.uniprot.org/uniprot/H9H9Y9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:MB ^@ http://purl.uniprot.org/uniprot/G1RW45 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. http://togogenome.org/gene/61853:HBP1 ^@ http://purl.uniprot.org/uniprot/G1RBX7 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. http://togogenome.org/gene/61853:TRPV1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HJR2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:HIKESHI ^@ http://purl.uniprot.org/uniprot/G1S2D6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.|||Belongs to the OPI10 family.|||Cytoplasm|||Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.|||Nucleus|||cytosol http://togogenome.org/gene/61853:CDCA7L ^@ http://purl.uniprot.org/uniprot/A0A2I3H1F4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/61853:POLL ^@ http://purl.uniprot.org/uniprot/G1RXX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/61853:OPHN1 ^@ http://purl.uniprot.org/uniprot/G1QII6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Postsynapse|||Presynapse|||dendrite http://togogenome.org/gene/61853:IL31RA ^@ http://purl.uniprot.org/uniprot/A0A2I3G9E7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:RRP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G2R0 ^@ Similarity ^@ Belongs to the RRP1 family. http://togogenome.org/gene/61853:HSPB2 ^@ http://purl.uniprot.org/uniprot/G1R6R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/61853:FAM110D ^@ http://purl.uniprot.org/uniprot/G1SAD0 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/61853:SDE2 ^@ http://purl.uniprot.org/uniprot/G1RU05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SDE2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:GSTK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G4I9|||http://purl.uniprot.org/uniprot/A0A2I3HMT9 ^@ Similarity ^@ Belongs to the GST superfamily. Kappa family. http://togogenome.org/gene/61853:PLRG1 ^@ http://purl.uniprot.org/uniprot/G1R297 ^@ Similarity ^@ Belongs to the WD repeat PRL1/PRL2 family. http://togogenome.org/gene/61853:SPOPL ^@ http://purl.uniprot.org/uniprot/H9HA37 ^@ Similarity ^@ Belongs to the Tdpoz family. http://togogenome.org/gene/61853:NELFCD ^@ http://purl.uniprot.org/uniprot/G1REH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NELF-D family.|||Nucleus http://togogenome.org/gene/61853:DPH2 ^@ http://purl.uniprot.org/uniprot/A0A2I3H0Y5 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family. DPH2 subfamily.|||Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit. http://togogenome.org/gene/61853:NFIB ^@ http://purl.uniprot.org/uniprot/A0A2I3GME2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/61853:CAMK2D ^@ http://purl.uniprot.org/uniprot/A0A2I3GBU5|||http://purl.uniprot.org/uniprot/A0A2I3H8G5|||http://purl.uniprot.org/uniprot/G1S2H9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/61853:ROCK2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GWR7 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by RHOA binding. Inhibited by Y-27632.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cell membrane|||Homodimer.|||Membrane|||Nucleus|||Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.|||centrosome http://togogenome.org/gene/61853:TOMM40L ^@ http://purl.uniprot.org/uniprot/A0A2I3HEC8|||http://purl.uniprot.org/uniprot/G1RVR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/61853:APIP ^@ http://purl.uniprot.org/uniprot/A0A2I3GH41 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aldolase class II family. Adducin subfamily.|||Belongs to the aldolase class II family. MtnB subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.|||Cytoplasm|||Homotetramer. Interacts with APAF1. May interact with CASP1. http://togogenome.org/gene/61853:RPS27L ^@ http://purl.uniprot.org/uniprot/A0A2I3FPV2|||http://purl.uniprot.org/uniprot/A0A2I3GXM5 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/61853:PARD6B ^@ http://purl.uniprot.org/uniprot/G1R5Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/61853:PFDN6 ^@ http://purl.uniprot.org/uniprot/A0A2I3HQ15 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/61853:VAX1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H569|||http://purl.uniprot.org/uniprot/G1S3J8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:PCLAF ^@ http://purl.uniprot.org/uniprot/A0A2I3GDK4|||http://purl.uniprot.org/uniprot/A0A2I3HEH3 ^@ Subcellular Location Annotation ^@ Nucleus|||perinuclear region http://togogenome.org/gene/61853:GATA4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GVE3|||http://purl.uniprot.org/uniprot/G1RYG7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:TMEM35A ^@ http://purl.uniprot.org/uniprot/G1R7H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/61853:DNMBP ^@ http://purl.uniprot.org/uniprot/A0A2I3HTE0 ^@ Subcellular Location Annotation ^@ Cell junction|||Golgi stack|||Synapse|||cytoskeleton http://togogenome.org/gene/61853:CDKN2AIP ^@ http://purl.uniprot.org/uniprot/G1RIG6 ^@ Similarity ^@ Belongs to the CARF family. http://togogenome.org/gene/61853:IGF1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H886|||http://purl.uniprot.org/uniprot/A0A2I3HN66|||http://purl.uniprot.org/uniprot/G1R3K2|||http://purl.uniprot.org/uniprot/G1R3K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/61853:MCM4 ^@ http://purl.uniprot.org/uniprot/G1RSG6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/61853:TOP1MT ^@ http://purl.uniprot.org/uniprot/G1QM08 ^@ Function|||Similarity ^@ Belongs to the type IB topoisomerase family.|||Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/61853:CMTM7 ^@ http://purl.uniprot.org/uniprot/A0A2I3H1Y3|||http://purl.uniprot.org/uniprot/A0A2I3HFX0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:SLC30A4 ^@ http://purl.uniprot.org/uniprot/G1R1Q1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/61853:NPM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HRX0|||http://purl.uniprot.org/uniprot/G1QHL3 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/61853:MCEE ^@ http://purl.uniprot.org/uniprot/G1RH09 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/61853:NEUROD4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HLJ8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:SYNCRIP ^@ http://purl.uniprot.org/uniprot/A0A2I3HDZ4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:COQ10B ^@ http://purl.uniprot.org/uniprot/A0A2I3GES0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/61853:LOC100582668 ^@ http://purl.uniprot.org/uniprot/G1RIN2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:TAC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G5G5|||http://purl.uniprot.org/uniprot/G1S1Q4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted|||Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. http://togogenome.org/gene/61853:PSMB9 ^@ http://purl.uniprot.org/uniprot/G1R4W3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:HOXD8 ^@ http://purl.uniprot.org/uniprot/G1R243 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:PLA2G12A ^@ http://purl.uniprot.org/uniprot/A0A2I3HQZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Secreted http://togogenome.org/gene/61853:LOC100606303 ^@ http://purl.uniprot.org/uniprot/G1QP91 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/61853:BVES ^@ http://purl.uniprot.org/uniprot/G1RVB5 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/61853:PEMT ^@ http://purl.uniprot.org/uniprot/G1RTA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.|||Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/61853:PSMD7 ^@ http://purl.uniprot.org/uniprot/A0A2I3GQ47 ^@ Similarity ^@ Belongs to the peptidase M67A family. http://togogenome.org/gene/61853:PUS10 ^@ http://purl.uniprot.org/uniprot/G1REG8 ^@ Similarity ^@ Belongs to the pseudouridine synthase Pus10 family. http://togogenome.org/gene/61853:IL17RD ^@ http://purl.uniprot.org/uniprot/G1R6M3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:RTRAF ^@ http://purl.uniprot.org/uniprot/G1RPC2 ^@ Similarity ^@ Belongs to the RTRAF family. http://togogenome.org/gene/61853:NRG1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GPY6|||http://purl.uniprot.org/uniprot/A0A2I3GY30|||http://purl.uniprot.org/uniprot/A0A2I3HCM6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neuregulin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/61853:ELOVL3 ^@ http://purl.uniprot.org/uniprot/G1RYE8 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL3 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-Glycosylated.|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/61853:DAZAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G342 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus speckle|||nuclear body http://togogenome.org/gene/61853:HYI ^@ http://purl.uniprot.org/uniprot/A0A2I3HZY4 ^@ Function|||Similarity ^@ Belongs to the hyi family.|||Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). http://togogenome.org/gene/61853:ERBB3 ^@ http://purl.uniprot.org/uniprot/G1S724 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/61853:ECHDC1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HF69 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/61853:RNF8 ^@ http://purl.uniprot.org/uniprot/G1RK27 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.|||Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.|||Belongs to the CHFR family.|||Belongs to the RNF8 family.|||Cytoplasm|||E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis. At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2.|||Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.|||Midbody|||Nucleus|||The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.|||telomere http://togogenome.org/gene/61853:MON2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GEP6|||http://purl.uniprot.org/uniprot/A0A2I3GH18|||http://purl.uniprot.org/uniprot/A0A2I3GNT3 ^@ Similarity ^@ Belongs to the MON2 family. http://togogenome.org/gene/61853:NPY1R ^@ http://purl.uniprot.org/uniprot/G1R3U0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:DYNC2LI1 ^@ http://purl.uniprot.org/uniprot/G1S499 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light intermediate chain family.|||centrosome|||cilium|||cilium axoneme|||cilium basal body http://togogenome.org/gene/61853:GRK7 ^@ http://purl.uniprot.org/uniprot/G1QXH1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/61853:TSHZ3 ^@ http://purl.uniprot.org/uniprot/G1R7S3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the teashirt C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/61853:NUDT18 ^@ http://purl.uniprot.org/uniprot/A0A2I3HER2 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/61853:IARS1 ^@ http://purl.uniprot.org/uniprot/G1S2U5 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/61853:ANK2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GRC7|||http://purl.uniprot.org/uniprot/A0A2I3HI48|||http://purl.uniprot.org/uniprot/G1S2U2 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/61853:H1-1 ^@ http://purl.uniprot.org/uniprot/G1S9Q1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/61853:ANP32E ^@ http://purl.uniprot.org/uniprot/A0A2I3HV86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/61853:TM6SF2 ^@ http://purl.uniprot.org/uniprot/G1R2Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TM6SF family.|||Membrane http://togogenome.org/gene/61853:PPP6C ^@ http://purl.uniprot.org/uniprot/G1S6A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/61853:SLC39A6 ^@ http://purl.uniprot.org/uniprot/G1R2Y1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:SENP7 ^@ http://purl.uniprot.org/uniprot/A0A2I3G8E2|||http://purl.uniprot.org/uniprot/A0A2I3GC85|||http://purl.uniprot.org/uniprot/G1QSH2 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/61853:SMARCAL1 ^@ http://purl.uniprot.org/uniprot/G1R6P9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.|||Nucleus http://togogenome.org/gene/61853:USP20 ^@ http://purl.uniprot.org/uniprot/G1S7E7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family. USP20/USP33 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||centrosome|||perinuclear region http://togogenome.org/gene/61853:DES ^@ http://purl.uniprot.org/uniprot/G1RE59 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/61853:MLLT11 ^@ http://purl.uniprot.org/uniprot/A0A2I3HR46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLLT11 family.|||Nucleus|||centrosome http://togogenome.org/gene/61853:FAM126B ^@ http://purl.uniprot.org/uniprot/G1R5J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/61853:SLAIN1 ^@ http://purl.uniprot.org/uniprot/G1S2Y3 ^@ Similarity ^@ Belongs to the SLAIN motif-containing family. http://togogenome.org/gene/61853:CDKN2AIPNL ^@ http://purl.uniprot.org/uniprot/A0A2I3GBS8 ^@ Similarity ^@ Belongs to the CARF family. http://togogenome.org/gene/61853:ANXA13 ^@ http://purl.uniprot.org/uniprot/A0A2I3H4Q7|||http://purl.uniprot.org/uniprot/G1QZZ3 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/61853:JPH1 ^@ http://purl.uniprot.org/uniprot/G1QM66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/61853:NSMCE1 ^@ http://purl.uniprot.org/uniprot/G1RLW2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE1 family.|||Component of the Smc5-Smc6 complex.|||Nucleus|||RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.|||telomere http://togogenome.org/gene/61853:ZDHHC3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HE14 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/61853:BAMBI ^@ http://purl.uniprot.org/uniprot/G1S5A1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BAMBI family.|||Membrane|||Negatively regulates TGF-beta signaling. http://togogenome.org/gene/61853:ABCG2 ^@ http://purl.uniprot.org/uniprot/G1REW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/61853:RBP4 ^@ http://purl.uniprot.org/uniprot/G1RQU1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Interacts with TTR.|||Retinol-binding protein that mediates retinol transport in blood plasma.|||Secreted http://togogenome.org/gene/61853:GDAP2 ^@ http://purl.uniprot.org/uniprot/G1QZN2 ^@ Similarity ^@ Belongs to the GDAP2 family. http://togogenome.org/gene/61853:SLC23A3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HYR4|||http://purl.uniprot.org/uniprot/G1RCV5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:DEGS2 ^@ http://purl.uniprot.org/uniprot/G1QJS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:POLR2M ^@ http://purl.uniprot.org/uniprot/G1RKB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRINL1 family.|||Nucleus http://togogenome.org/gene/61853:DOK1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HKC9 ^@ Similarity ^@ Belongs to the DOK family. Type A subfamily. http://togogenome.org/gene/61853:LOC100592247 ^@ http://purl.uniprot.org/uniprot/G1S987 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:CPA3 ^@ http://purl.uniprot.org/uniprot/G1QQ60 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/61853:PMVK ^@ http://purl.uniprot.org/uniprot/G1RL78 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/61853:NOL11 ^@ http://purl.uniprot.org/uniprot/G1QLL5 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/61853:RHAG ^@ http://purl.uniprot.org/uniprot/G1QVQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/61853:ATRAID ^@ http://purl.uniprot.org/uniprot/G1QS17 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:GPRC5A ^@ http://purl.uniprot.org/uniprot/G1QU36 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:CLDN10 ^@ http://purl.uniprot.org/uniprot/A0A2I3H220|||http://purl.uniprot.org/uniprot/G1S3S7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/61853:KCNG4 ^@ http://purl.uniprot.org/uniprot/G1RJQ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:TRAF2 ^@ http://purl.uniprot.org/uniprot/G1RBD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/61853:RSBN1L ^@ http://purl.uniprot.org/uniprot/G1REJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the round spermatid basic protein 1 family.|||Nucleus http://togogenome.org/gene/61853:LOC100605975 ^@ http://purl.uniprot.org/uniprot/A0A2I3I0K6 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/61853:LOC100583649 ^@ http://purl.uniprot.org/uniprot/G1S979 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:MRPL12 ^@ http://purl.uniprot.org/uniprot/A0A2I3H9N0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL12 family. http://togogenome.org/gene/61853:CD4 ^@ http://purl.uniprot.org/uniprot/G1QXL1 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/61853:TNPO1 ^@ http://purl.uniprot.org/uniprot/G1QXD5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:PIGF ^@ http://purl.uniprot.org/uniprot/A0A2I3GKT2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:MPHOSPH8 ^@ http://purl.uniprot.org/uniprot/G1QKR0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:XRCC5 ^@ http://purl.uniprot.org/uniprot/G1R6P0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ku80 family.|||Nucleus|||Single-stranded DNA-dependent ATP-dependent helicase. http://togogenome.org/gene/61853:SLC15A2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G8C1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Interacts (via extracellular domain region) with trypsin.|||Membrane http://togogenome.org/gene/61853:GJD4 ^@ http://purl.uniprot.org/uniprot/G1S963 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/61853:CD8A ^@ http://purl.uniprot.org/uniprot/A0A2I3GKY7|||http://purl.uniprot.org/uniprot/G1QRH2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:NFU1 ^@ http://purl.uniprot.org/uniprot/G1RGG8 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/61853:TCL1A ^@ http://purl.uniprot.org/uniprot/G1QI40 ^@ Similarity ^@ Belongs to the TCL1 family. http://togogenome.org/gene/61853:SLC39A7 ^@ http://purl.uniprot.org/uniprot/G1R529 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:FAM118B ^@ http://purl.uniprot.org/uniprot/G1R7B4 ^@ Similarity ^@ Belongs to the FAM118 family. http://togogenome.org/gene/61853:LOC100597818 ^@ http://purl.uniprot.org/uniprot/G1SCA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:CLCN2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G1M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:LOC100605934 ^@ http://purl.uniprot.org/uniprot/G1RIZ1 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/61853:FCER1G ^@ http://purl.uniprot.org/uniprot/A0A2I3GZ40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD3Z/FCER1G family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:PSMC1 ^@ http://purl.uniprot.org/uniprot/G1S597 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/61853:SCG5 ^@ http://purl.uniprot.org/uniprot/G1RIB1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.|||Belongs to the 7B2 family.|||Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.|||Secreted http://togogenome.org/gene/61853:KITLG ^@ http://purl.uniprot.org/uniprot/G1R0E6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCF family.|||Cytoplasm|||Homodimer, non-covalently linked.|||Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.|||Secreted|||filopodium|||lamellipodium http://togogenome.org/gene/61853:FMO3 ^@ http://purl.uniprot.org/uniprot/G1RYS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.|||Membrane|||Microsome membrane http://togogenome.org/gene/61853:TAS2R38 ^@ http://purl.uniprot.org/uniprot/G1S9X6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane|||Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. http://togogenome.org/gene/61853:KHDC3L ^@ http://purl.uniprot.org/uniprot/G1QKH1 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/61853:TRIM36 ^@ http://purl.uniprot.org/uniprot/A0A2I3GL73|||http://purl.uniprot.org/uniprot/G1RLZ8 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/61853:GINS4 ^@ http://purl.uniprot.org/uniprot/G1RPX3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS4/SLD5 family.|||Chromosome|||Nucleus|||Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/61853:VEGFD ^@ http://purl.uniprot.org/uniprot/G1RDV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Secreted http://togogenome.org/gene/61853:NUP50 ^@ http://purl.uniprot.org/uniprot/A0A2I3H5A5 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/61853:ZSCAN21 ^@ http://purl.uniprot.org/uniprot/A0A2I3GAQ2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:NDUFAF7 ^@ http://purl.uniprot.org/uniprot/A0A2I3HG06|||http://purl.uniprot.org/uniprot/A0A2I3HTN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Belongs to the NDUFAF7 family.|||Mitochondrion http://togogenome.org/gene/61853:CNDP1 ^@ http://purl.uniprot.org/uniprot/G1RDM3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/61853:POU4F3 ^@ http://purl.uniprot.org/uniprot/G1RFQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/61853:CCN4 ^@ http://purl.uniprot.org/uniprot/A0A2I3H175 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:SDR16C5 ^@ http://purl.uniprot.org/uniprot/G1QKS8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/61853:GALC ^@ http://purl.uniprot.org/uniprot/G1S4R5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 59 family. http://togogenome.org/gene/61853:ICAM2 ^@ http://purl.uniprot.org/uniprot/G1RYL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/61853:MTNR1A ^@ http://purl.uniprot.org/uniprot/G1RLF2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.|||Membrane http://togogenome.org/gene/61853:ORC4 ^@ http://purl.uniprot.org/uniprot/G1RCY1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC4 family.|||Component of the origin recognition complex (ORC) that binds origins of replication.|||Nucleus http://togogenome.org/gene/61853:MCTS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HB06|||http://purl.uniprot.org/uniprot/G1RYD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCTS1 family.|||Cytoplasm http://togogenome.org/gene/61853:LPGAT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H1Z4 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/61853:TATDN2 ^@ http://purl.uniprot.org/uniprot/G1QWQ4 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/61853:ENY2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GR30|||http://purl.uniprot.org/uniprot/G1QW82 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.|||nucleoplasm http://togogenome.org/gene/61853:ALX1 ^@ http://purl.uniprot.org/uniprot/G1QZZ6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:SYT16 ^@ http://purl.uniprot.org/uniprot/G1RUV8 ^@ Similarity ^@ Belongs to the synaptotagmin family. http://togogenome.org/gene/61853:EPHA10 ^@ http://purl.uniprot.org/uniprot/A0A2I3GM05 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:LOC100590137 ^@ http://purl.uniprot.org/uniprot/G1RUC9 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/61853:RAB3A ^@ http://purl.uniprot.org/uniprot/G1R1W8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/61853:GNB4 ^@ http://purl.uniprot.org/uniprot/G1R1B0 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/61853:VARS1 ^@ http://purl.uniprot.org/uniprot/G1R3G6 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/61853:IL17C ^@ http://purl.uniprot.org/uniprot/G1QIB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/61853:CHRNA3 ^@ http://purl.uniprot.org/uniprot/G1RBG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/61853:ZSCAN9 ^@ http://purl.uniprot.org/uniprot/G1QWX9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:CLUAP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HX61|||http://purl.uniprot.org/uniprot/G1REX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLUAP1 family.|||cilium http://togogenome.org/gene/61853:GDPD2 ^@ http://purl.uniprot.org/uniprot/G1QJL8 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/61853:CHMP4C ^@ http://purl.uniprot.org/uniprot/G1QQI6 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/61853:UNC119 ^@ http://purl.uniprot.org/uniprot/G1QPD9 ^@ Similarity ^@ Belongs to the PDE6D/unc-119 family. http://togogenome.org/gene/61853:PLBD1 ^@ http://purl.uniprot.org/uniprot/G1QUM3 ^@ Function|||Similarity ^@ Belongs to the phospholipase B-like family.|||Putative phospholipase. http://togogenome.org/gene/61853:ZFX ^@ http://purl.uniprot.org/uniprot/A0A2I3GH74|||http://purl.uniprot.org/uniprot/A0A2I3H6E2|||http://purl.uniprot.org/uniprot/G1RGA3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:LOC100598111 ^@ http://purl.uniprot.org/uniprot/A0A2I3HY51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hcp beta-lactamase family.|||Mitochondrion intermembrane space|||Required for assembly of mitochondrial respiratory chain complexes. http://togogenome.org/gene/61853:NKAP ^@ http://purl.uniprot.org/uniprot/A0A2I3HHC6 ^@ Similarity ^@ Belongs to the NKAP family. http://togogenome.org/gene/61853:BTF3L4 ^@ http://purl.uniprot.org/uniprot/A0A2I3G0R7 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/61853:CLDN1 ^@ http://purl.uniprot.org/uniprot/G1R4T2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/61853:NDUFAB1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G5C2 ^@ Function|||Similarity ^@ Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis. http://togogenome.org/gene/61853:GABRR3 ^@ http://purl.uniprot.org/uniprot/G1QNS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/61853:LOC100581059 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBI7 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/61853:NCF2 ^@ http://purl.uniprot.org/uniprot/G1S8Q4 ^@ Similarity ^@ Belongs to the NCF2/NOXA1 family. http://togogenome.org/gene/61853:DOLK ^@ http://purl.uniprot.org/uniprot/G1SBG5 ^@ Similarity ^@ Belongs to the polyprenol kinase family. http://togogenome.org/gene/61853:SLC25A3 ^@ http://purl.uniprot.org/uniprot/G1R250 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Interacts with PPIF; the interaction is impaired by CsA.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:RNASE7 ^@ http://purl.uniprot.org/uniprot/G1RVR6 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/61853:SMC4 ^@ http://purl.uniprot.org/uniprot/G1QX56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family.|||Chromosome|||Nucleus http://togogenome.org/gene/61853:PRLR ^@ http://purl.uniprot.org/uniprot/A0A2I3FZT0|||http://purl.uniprot.org/uniprot/A0A2I3H091 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.|||Membrane|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation.|||This is a receptor for the anterior pituitary hormone prolactin. http://togogenome.org/gene/61853:CCDC65 ^@ http://purl.uniprot.org/uniprot/G1S861 ^@ Subcellular Location Annotation ^@ flagellum axoneme http://togogenome.org/gene/61853:IRF8 ^@ http://purl.uniprot.org/uniprot/G1RL04 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:NSDHL ^@ http://purl.uniprot.org/uniprot/G1RUE7 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/61853:POLR2I ^@ http://purl.uniprot.org/uniprot/G1RLW6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/61853:BLCAP ^@ http://purl.uniprot.org/uniprot/A0A2I3GB38 ^@ Function|||Similarity ^@ Belongs to the BLCAP family.|||May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B. http://togogenome.org/gene/61853:PAN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HWC7 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. PAN3 family.|||Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.|||Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate specificity of the enzyme complex. Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6C.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||P-body|||Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.|||The N-terminal zinc finger binds to poly(A) RNA.|||The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2. http://togogenome.org/gene/61853:C23H8orf82 ^@ http://purl.uniprot.org/uniprot/G1RJ30 ^@ Similarity ^@ Belongs to the UPF0598 family. http://togogenome.org/gene/61853:RDH16 ^@ http://purl.uniprot.org/uniprot/G1S6M0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/61853:EFEMP2 ^@ http://purl.uniprot.org/uniprot/G1R1T3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:GPD1 ^@ http://purl.uniprot.org/uniprot/G1S7Y5 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/61853:NFE2 ^@ http://purl.uniprot.org/uniprot/G1S7D8 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/61853:MYH8 ^@ http://purl.uniprot.org/uniprot/G1RGR0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/61853:LSM2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GHD4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||Nucleus http://togogenome.org/gene/61853:CNTFR ^@ http://purl.uniprot.org/uniprot/G1QYB4 ^@ Similarity ^@ Belongs to the type I cytokine receptor family. Type 3 subfamily. http://togogenome.org/gene/61853:FAM135B ^@ http://purl.uniprot.org/uniprot/G1RIW3 ^@ Similarity ^@ Belongs to the FAM135 family. http://togogenome.org/gene/61853:LHFPL1 ^@ http://purl.uniprot.org/uniprot/G1RX02 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:RPS7 ^@ http://purl.uniprot.org/uniprot/A0A2I3GS23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eS7 family.|||centrosome http://togogenome.org/gene/61853:CPB1 ^@ http://purl.uniprot.org/uniprot/G1QQ02 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/61853:PER2 ^@ http://purl.uniprot.org/uniprot/G1RKG3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/61853:NGRN ^@ http://purl.uniprot.org/uniprot/G1RMW6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neugrin family.|||Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.|||Mitochondrion membrane|||Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system. http://togogenome.org/gene/61853:NR1H4 ^@ http://purl.uniprot.org/uniprot/G1R2I6|||http://purl.uniprot.org/uniprot/G1R2J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/61853:SLC22A4 ^@ http://purl.uniprot.org/uniprot/G1RQ89 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Basal cell membrane|||Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Cell membrane|||Interacts with PDZK1. http://togogenome.org/gene/61853:GALNT18 ^@ http://purl.uniprot.org/uniprot/G1S7D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:HMCES ^@ http://purl.uniprot.org/uniprot/A0A2I3GTI7 ^@ Function|||Similarity ^@ Belongs to the SOS response-associated peptidase family.|||Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction. http://togogenome.org/gene/61853:CLDN14 ^@ http://purl.uniprot.org/uniprot/G1QWU0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/61853:LOC100605713 ^@ http://purl.uniprot.org/uniprot/G1SCB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:LOC100605310 ^@ http://purl.uniprot.org/uniprot/A0A2I3HWV8 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/61853:CERS3 ^@ http://purl.uniprot.org/uniprot/G1QJT3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/61853:BABAM1 ^@ http://purl.uniprot.org/uniprot/G1R146 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BABAM1 family.|||Nucleus http://togogenome.org/gene/61853:RHOXF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HAY5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:FASLG ^@ http://purl.uniprot.org/uniprot/A0A2I3G609|||http://purl.uniprot.org/uniprot/G1RZ55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tumor necrosis factor family.|||Cell membrane|||Cytoplasmic form induces gene transcription inhibition.|||Cytoplasmic vesicle lumen|||Lysosome lumen|||Nucleus|||Secreted http://togogenome.org/gene/61853:DPCD ^@ http://purl.uniprot.org/uniprot/G1RXX7 ^@ Similarity ^@ Belongs to the DPCD family. http://togogenome.org/gene/61853:HJV ^@ http://purl.uniprot.org/uniprot/G1R1I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:CAVIN2 ^@ http://purl.uniprot.org/uniprot/G1R4X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/61853:SLC17A4 ^@ http://purl.uniprot.org/uniprot/A0A2I3G357|||http://purl.uniprot.org/uniprot/G1QRA4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:LEPROT ^@ http://purl.uniprot.org/uniprot/A0A2I3HI55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/61853:ENTR1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HNT4|||http://purl.uniprot.org/uniprot/G1R9U7 ^@ Similarity ^@ Belongs to the ENTR1 family. http://togogenome.org/gene/61853:STMN3 ^@ http://purl.uniprot.org/uniprot/G1RGG5 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/61853:IL1RAP ^@ http://purl.uniprot.org/uniprot/A0A2I3HX22|||http://purl.uniprot.org/uniprot/G1R4V0 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/61853:LOC100580500 ^@ http://purl.uniprot.org/uniprot/G1RRR6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/61853:SLC7A1 ^@ http://purl.uniprot.org/uniprot/G1QIM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:PDE5A ^@ http://purl.uniprot.org/uniprot/G1RCW7|||http://purl.uniprot.org/uniprot/G1RCW9 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/61853:PAPSS2 ^@ http://purl.uniprot.org/uniprot/G1RNB1 ^@ Similarity ^@ In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family. http://togogenome.org/gene/61853:OLFM4 ^@ http://purl.uniprot.org/uniprot/G1S108 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:PCNA ^@ http://purl.uniprot.org/uniprot/G1R863 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PCNA family.|||Nucleus|||This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. http://togogenome.org/gene/61853:RGN ^@ http://purl.uniprot.org/uniprot/G1QRR9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/61853:SMAD3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HD56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/61853:GRK5 ^@ http://purl.uniprot.org/uniprot/G1S461 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/61853:PSMA2 ^@ http://purl.uniprot.org/uniprot/G1QSE5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/61853:PAGE4 ^@ http://purl.uniprot.org/uniprot/G1R9J0 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/61853:CENPH ^@ http://purl.uniprot.org/uniprot/A0A2I3G2B9|||http://purl.uniprot.org/uniprot/A0A2I3HNA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-H/MCM16 family.|||Nucleus|||kinetochore http://togogenome.org/gene/61853:SIAH3 ^@ http://purl.uniprot.org/uniprot/G1QPZ2 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/61853:SEC61A2 ^@ http://purl.uniprot.org/uniprot/G1RP04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:SLC25A34 ^@ http://purl.uniprot.org/uniprot/G1R7W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/61853:TSPO2 ^@ http://purl.uniprot.org/uniprot/G1QYW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/61853:CMAS ^@ http://purl.uniprot.org/uniprot/G1QYJ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CMP-NeuNAc synthase family.|||Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).|||Homotetramer; the active enzyme is formed by a dimer of dimers. http://togogenome.org/gene/61853:UTP25 ^@ http://purl.uniprot.org/uniprot/G1QNG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP25 family.|||nucleolus http://togogenome.org/gene/61853:TSR2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GBF4 ^@ Function|||Similarity ^@ Belongs to the TSR2 family.|||May be involved in 20S pre-rRNA processing. http://togogenome.org/gene/61853:LOC100595785 ^@ http://purl.uniprot.org/uniprot/A0A2I3G3E0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/61853:ALDH1L2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GN32 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.|||In the N-terminal section; belongs to the GART family. http://togogenome.org/gene/61853:SLITRK3 ^@ http://purl.uniprot.org/uniprot/G1QY30 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/61853:MTMR10 ^@ http://purl.uniprot.org/uniprot/G1R7I7 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/61853:CDK8 ^@ http://purl.uniprot.org/uniprot/G1RUX2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:HFE ^@ http://purl.uniprot.org/uniprot/A0A2I3FYK5|||http://purl.uniprot.org/uniprot/A0A2I3G7K2|||http://purl.uniprot.org/uniprot/A0A2I3HV94 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/61853:WDPCP ^@ http://purl.uniprot.org/uniprot/G1RFG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat fritz family.|||Cell membrane|||Membrane|||cilium axoneme http://togogenome.org/gene/61853:CDC42BPA ^@ http://purl.uniprot.org/uniprot/A0A2I3GH26|||http://purl.uniprot.org/uniprot/A0A2I3H8W7|||http://purl.uniprot.org/uniprot/G1RV13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.|||Cytoplasm|||lamellipodium http://togogenome.org/gene/61853:LOC100588482 ^@ http://purl.uniprot.org/uniprot/A0A080YV12|||http://purl.uniprot.org/uniprot/A0A2I3H6E0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/61853:LOC100587834 ^@ http://purl.uniprot.org/uniprot/G1SBF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:API5 ^@ http://purl.uniprot.org/uniprot/G1S8H4 ^@ Similarity ^@ Belongs to the API5 family. http://togogenome.org/gene/61853:RBBP8 ^@ http://purl.uniprot.org/uniprot/E5FGF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COM1/SAE2/CtIP family.|||Nucleus http://togogenome.org/gene/61853:CASP10 ^@ http://purl.uniprot.org/uniprot/G1R5K0 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/61853:IL17F ^@ http://purl.uniprot.org/uniprot/G1QUR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/61853:CCNH ^@ http://purl.uniprot.org/uniprot/A0A2I3HFR1|||http://purl.uniprot.org/uniprot/G1RTE2 ^@ Function|||Similarity|||Subunit ^@ Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.|||Belongs to the cyclin family. Cyclin C subfamily.|||Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. http://togogenome.org/gene/61853:SLC25A19 ^@ http://purl.uniprot.org/uniprot/G1QJA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/61853:TXLNA ^@ http://purl.uniprot.org/uniprot/G1QPJ4 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/61853:IDNK ^@ http://purl.uniprot.org/uniprot/A0A2I3GDV0|||http://purl.uniprot.org/uniprot/A0A2I3GKW0 ^@ Similarity ^@ Belongs to the gluconokinase GntK/GntV family. http://togogenome.org/gene/61853:LOC100584631 ^@ http://purl.uniprot.org/uniprot/A0A2I3GC38 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:LOC100599005 ^@ http://purl.uniprot.org/uniprot/A0A2I3HB07|||http://purl.uniprot.org/uniprot/G1QM39 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/61853:KCNK10 ^@ http://purl.uniprot.org/uniprot/A0A2I3HW31|||http://purl.uniprot.org/uniprot/G1S4S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/61853:PPP2R2B ^@ http://purl.uniprot.org/uniprot/A0A2I3G9W4|||http://purl.uniprot.org/uniprot/A0A2I3H1R1|||http://purl.uniprot.org/uniprot/A0A2I3HFK1|||http://purl.uniprot.org/uniprot/A0A2I3HMQ3|||http://purl.uniprot.org/uniprot/A0A2I3HWZ5 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/61853:OPALIN ^@ http://purl.uniprot.org/uniprot/A0A2I3GZJ4|||http://purl.uniprot.org/uniprot/G1RSN4 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.|||Membrane http://togogenome.org/gene/61853:EXO5 ^@ http://purl.uniprot.org/uniprot/A0A2I3G362 ^@ Similarity ^@ Belongs to the EXO5 family. http://togogenome.org/gene/61853:LOC100579420 ^@ http://purl.uniprot.org/uniprot/A0A2I3GIJ3|||http://purl.uniprot.org/uniprot/A0A2I3HC64 ^@ Similarity ^@ Belongs to the CBP3 family. http://togogenome.org/gene/61853:TMED3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GZ70|||http://purl.uniprot.org/uniprot/G1RC42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/61853:MRPL18 ^@ http://purl.uniprot.org/uniprot/G1RKD7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL18 family. http://togogenome.org/gene/61853:TYW3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GK38|||http://purl.uniprot.org/uniprot/G1REI8 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. http://togogenome.org/gene/61853:CPSF7 ^@ http://purl.uniprot.org/uniprot/G1QQB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM CPSF6/7 family.|||Nucleus http://togogenome.org/gene/61853:CD59 ^@ http://purl.uniprot.org/uniprot/A0A2I3HZX1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:MEIS1 ^@ http://purl.uniprot.org/uniprot/G1RFZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/61853:FAM163A ^@ http://purl.uniprot.org/uniprot/G1S0X9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/61853:CALCA ^@ http://purl.uniprot.org/uniprot/G1S7K5|||http://purl.uniprot.org/uniprot/H9H9X5 ^@ Similarity ^@ Belongs to the calcitonin family. http://togogenome.org/gene/61853:LOC100591680 ^@ http://purl.uniprot.org/uniprot/G1RCK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.|||Secreted http://togogenome.org/gene/61853:PDHB ^@ http://purl.uniprot.org/uniprot/G1R6U9 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. http://togogenome.org/gene/61853:PRKCI ^@ http://purl.uniprot.org/uniprot/M3Z9F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/61853:CDK5RAP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HGD5 ^@ Similarity ^@ Belongs to the methylthiotransferase family. MiaB subfamily. http://togogenome.org/gene/61853:MICOS13 ^@ http://purl.uniprot.org/uniprot/A0A2I3H0S7|||http://purl.uniprot.org/uniprot/G1RTJ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic13 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:GPAM ^@ http://purl.uniprot.org/uniprot/A0A2I3H987|||http://purl.uniprot.org/uniprot/G1S0K6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.|||Mitochondrion outer membrane http://togogenome.org/gene/61853:ACKR4 ^@ http://purl.uniprot.org/uniprot/G1QT16 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:ABITRAM ^@ http://purl.uniprot.org/uniprot/G1S6F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABITRAM family.|||growth cone|||lamellipodium http://togogenome.org/gene/61853:CRYBA1 ^@ http://purl.uniprot.org/uniprot/G1QSR4 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/61853:TOLLIP ^@ http://purl.uniprot.org/uniprot/G1RRS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tollip family.|||Cytoplasm http://togogenome.org/gene/61853:KCNMB4 ^@ http://purl.uniprot.org/uniprot/A0A2I3FT66 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/61853:SLC7A14 ^@ http://purl.uniprot.org/uniprot/G1QZL3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:FN3KRP ^@ http://purl.uniprot.org/uniprot/G1RHW6 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/61853:TRAPPC2 ^@ http://purl.uniprot.org/uniprot/G1RD70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/61853:SPATA18 ^@ http://purl.uniprot.org/uniprot/A0A2I3HUG2|||http://purl.uniprot.org/uniprot/G1R9P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIEAP family.|||Cytoplasm|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/61853:ZNF165 ^@ http://purl.uniprot.org/uniprot/G1QWS9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:COLEC12 ^@ http://purl.uniprot.org/uniprot/G1R560 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:FMNL3 ^@ http://purl.uniprot.org/uniprot/A0A2I3H8A6|||http://purl.uniprot.org/uniprot/G1S809 ^@ Similarity ^@ Belongs to the formin homology family. http://togogenome.org/gene/61853:LOC100589568 ^@ http://purl.uniprot.org/uniprot/G1S3F6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRH/QCR6 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:RBP1 ^@ http://purl.uniprot.org/uniprot/G1QWT2 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/61853:CHN2 ^@ http://purl.uniprot.org/uniprot/A0A2I3H2B1 ^@ Function ^@ GTPase-activating protein for p21-rac. http://togogenome.org/gene/61853:TMEM70 ^@ http://purl.uniprot.org/uniprot/A0A2I3GSW6 ^@ Similarity ^@ Belongs to the TMEM70 family. http://togogenome.org/gene/61853:SLC27A2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GWT7|||http://purl.uniprot.org/uniprot/G1R2W0 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/61853:LPIN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GB02 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/61853:RAB14 ^@ http://purl.uniprot.org/uniprot/G1S5J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Recycling endosome|||phagosome|||trans-Golgi network membrane http://togogenome.org/gene/61853:TDP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H8R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosyl-DNA phosphodiesterase family.|||Nucleus http://togogenome.org/gene/61853:ZDHHC7 ^@ http://purl.uniprot.org/uniprot/G1RKQ5|||http://purl.uniprot.org/uniprot/M3Z9X7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/61853:RNF167 ^@ http://purl.uniprot.org/uniprot/G1S6M6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:SKIL ^@ http://purl.uniprot.org/uniprot/A0A2I3HLQ5 ^@ Similarity ^@ Belongs to the SKI family. http://togogenome.org/gene/61853:DMRT1 ^@ http://purl.uniprot.org/uniprot/G1RB29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/61853:CCSER1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HDQ8|||http://purl.uniprot.org/uniprot/G1RVX8 ^@ Similarity ^@ Belongs to the CCSER family. http://togogenome.org/gene/61853:SLC16A14 ^@ http://purl.uniprot.org/uniprot/G1RTQ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:MINPP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G8H7 ^@ Similarity ^@ Belongs to the histidine acid phosphatase family. MINPP1 subfamily. http://togogenome.org/gene/61853:MOS ^@ http://purl.uniprot.org/uniprot/G1S9U6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:LOC100584216 ^@ http://purl.uniprot.org/uniprot/G1R9R6 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/61853:SLC35E3 ^@ http://purl.uniprot.org/uniprot/G1QUA0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:POU1F1 ^@ http://purl.uniprot.org/uniprot/G1RM38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/61853:GNG3 ^@ http://purl.uniprot.org/uniprot/G1QVF4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/61853:FAM83B ^@ http://purl.uniprot.org/uniprot/G1QSV9 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/61853:DCPS ^@ http://purl.uniprot.org/uniprot/A0A2I3G3G5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HIT family.|||Cytoplasm|||Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.|||Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.|||Nucleus http://togogenome.org/gene/61853:CLN5 ^@ http://purl.uniprot.org/uniprot/G1S2F8 ^@ Similarity ^@ Belongs to the CLN5 family. http://togogenome.org/gene/61853:CA12 ^@ http://purl.uniprot.org/uniprot/A0A2I3GGB1|||http://purl.uniprot.org/uniprot/A0A2I3GKK7|||http://purl.uniprot.org/uniprot/G1RNT6 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/61853:XRCC1 ^@ http://purl.uniprot.org/uniprot/G1QLU6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:SLC25A40 ^@ http://purl.uniprot.org/uniprot/G1RYC9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:GAPVD1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GS49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAPVD1 family.|||Membrane http://togogenome.org/gene/61853:CX3CL1 ^@ http://purl.uniprot.org/uniprot/G1QRA5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/61853:VTI1A ^@ http://purl.uniprot.org/uniprot/A0A2I3HV17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/61853:ZMYND10 ^@ http://purl.uniprot.org/uniprot/G1R5R8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the ZMYND10 family.|||Dynein axonemal particle|||Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.|||centriolar satellite http://togogenome.org/gene/61853:HINT2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HTB9 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/61853:ZCCHC4 ^@ http://purl.uniprot.org/uniprot/G1S4J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZCCHC4 family.|||Cytoplasm|||nucleolus http://togogenome.org/gene/61853:GALNT15 ^@ http://purl.uniprot.org/uniprot/A0A2I3HYT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:IL1RN ^@ http://purl.uniprot.org/uniprot/A0A2I3GF91|||http://purl.uniprot.org/uniprot/G1QNA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/61853:KDM5A ^@ http://purl.uniprot.org/uniprot/G1QNE9 ^@ Similarity ^@ Belongs to the JARID1 histone demethylase family. http://togogenome.org/gene/61853:DTWD2 ^@ http://purl.uniprot.org/uniprot/A0A2I3H0D6 ^@ Similarity ^@ Belongs to the TDD superfamily. DTWD2 family. http://togogenome.org/gene/61853:VPS4B ^@ http://purl.uniprot.org/uniprot/A0A2I3GU19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/61853:MRPL37 ^@ http://purl.uniprot.org/uniprot/G1QT17 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/61853:OPRM1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HG76|||http://purl.uniprot.org/uniprot/A0A2I3HW22|||http://purl.uniprot.org/uniprot/G1RZV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Endosome|||Membrane|||Perikaryon|||axon|||dendrite http://togogenome.org/gene/61853:NEMP1 ^@ http://purl.uniprot.org/uniprot/G1S6L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NEMP family.|||Nucleus inner membrane http://togogenome.org/gene/61853:SLX1A ^@ http://purl.uniprot.org/uniprot/G1QJU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLX1 family.|||Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.|||Forms a heterodimer with SLX4.|||Nucleus http://togogenome.org/gene/61853:CRBN ^@ http://purl.uniprot.org/uniprot/G1QSV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRBN family.|||Nucleus http://togogenome.org/gene/61853:DCK ^@ http://purl.uniprot.org/uniprot/G1R861 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/61853:SAMHD1 ^@ http://purl.uniprot.org/uniprot/H6WEA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAMHD1 family.|||Chromosome http://togogenome.org/gene/61853:LOC100604314 ^@ http://purl.uniprot.org/uniprot/G1QPA8 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/61853:CPNE3 ^@ http://purl.uniprot.org/uniprot/G1QME0 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/61853:CORIN ^@ http://purl.uniprot.org/uniprot/A0A2I3GRQ5|||http://purl.uniprot.org/uniprot/G1S6D4 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:CLDN15 ^@ http://purl.uniprot.org/uniprot/G1RA19 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/61853:SLC18A1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G8S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Vesicular transporter family.|||Membrane|||secretory vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/61853:CDC25A ^@ http://purl.uniprot.org/uniprot/G1R3L4 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/61853:AMBN ^@ http://purl.uniprot.org/uniprot/G1R841 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ameloblastin family.|||Involved in the mineralization and structural organization of enamel.|||extracellular matrix http://togogenome.org/gene/61853:MBTPS1 ^@ http://purl.uniprot.org/uniprot/G1RJD6 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/61853:MAOA ^@ http://purl.uniprot.org/uniprot/A0A2I3HIJ8 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/61853:MIS18A ^@ http://purl.uniprot.org/uniprot/G1QTZ2 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.|||centromere http://togogenome.org/gene/61853:LOC100601771 ^@ http://purl.uniprot.org/uniprot/G1R4L8 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/61853:RPL8 ^@ http://purl.uniprot.org/uniprot/G1RJH7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/61853:AIDA ^@ http://purl.uniprot.org/uniprot/G1RTA2 ^@ Similarity ^@ Belongs to the AIDA family. http://togogenome.org/gene/61853:ATOH7 ^@ http://purl.uniprot.org/uniprot/A0A2I3H6E9 ^@ Subcellular Location Annotation ^@ Nucleus|||Perikaryon|||axon http://togogenome.org/gene/61853:BLK ^@ http://purl.uniprot.org/uniprot/M3ZCN7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/61853:COX1 ^@ http://purl.uniprot.org/uniprot/S4UW59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:PHYHIPL ^@ http://purl.uniprot.org/uniprot/G1RNU6 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/61853:PDE4A ^@ http://purl.uniprot.org/uniprot/G1RNP7 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/61853:PELI3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HPY9|||http://purl.uniprot.org/uniprot/G1R2J9 ^@ Function|||Similarity ^@ Belongs to the pellino family.|||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. http://togogenome.org/gene/61853:PSMD1 ^@ http://purl.uniprot.org/uniprot/G1RUV4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S1 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/61853:ZNF174 ^@ http://purl.uniprot.org/uniprot/A0A2I3G3X8|||http://purl.uniprot.org/uniprot/A0A2I3HF44 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:AADACL3 ^@ http://purl.uniprot.org/uniprot/A0A2I3G1B6 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/61853:ZFPL1 ^@ http://purl.uniprot.org/uniprot/G1R0B3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZFPL1 family.|||Interacts with GOLGA2/GM130.|||Membrane|||Required for cis-Golgi integrity and efficient ER to Golgi transport.|||The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.|||cis-Golgi network membrane http://togogenome.org/gene/61853:PTMA ^@ http://purl.uniprot.org/uniprot/G1RVF3 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/61853:NKX6-3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GZ42 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:KCNJ2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GE09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.|||Membrane http://togogenome.org/gene/61853:IL2 ^@ http://purl.uniprot.org/uniprot/G1RE34 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-2 family.|||Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.|||Secreted http://togogenome.org/gene/61853:PARP8 ^@ http://purl.uniprot.org/uniprot/A0A2I3HMT3 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/61853:MMP3 ^@ http://purl.uniprot.org/uniprot/G1R6D5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/61853:NDUFS6 ^@ http://purl.uniprot.org/uniprot/G1RK56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS6 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:QPCT ^@ http://purl.uniprot.org/uniprot/G1S2M5 ^@ Similarity ^@ Belongs to the glutaminyl-peptide cyclotransferase family. http://togogenome.org/gene/61853:CDX4 ^@ http://purl.uniprot.org/uniprot/G1QJW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/61853:MST1 ^@ http://purl.uniprot.org/uniprot/G1R5A0 ^@ Caution|||Similarity ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:CAPN6 ^@ http://purl.uniprot.org/uniprot/G1RWN6 ^@ Caution|||Similarity ^@ Belongs to the peptidase C2 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:TWF1 ^@ http://purl.uniprot.org/uniprot/G1S8E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.|||cytoskeleton http://togogenome.org/gene/61853:ONECUT1 ^@ http://purl.uniprot.org/uniprot/G1R460 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/61853:KPNA4 ^@ http://purl.uniprot.org/uniprot/G1QXC4 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/61853:NIPSNAP3A ^@ http://purl.uniprot.org/uniprot/A0A2I3GVK1 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/61853:ATP5PO ^@ http://purl.uniprot.org/uniprot/A0A2I3HI07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:TECR ^@ http://purl.uniprot.org/uniprot/G1RTP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:CEP70 ^@ http://purl.uniprot.org/uniprot/G1QWB0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.|||Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.|||centrosome http://togogenome.org/gene/61853:CBX5 ^@ http://purl.uniprot.org/uniprot/G1S7F7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:F2R ^@ http://purl.uniprot.org/uniprot/G1RQ03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:SFRP1 ^@ http://purl.uniprot.org/uniprot/G1RPU9 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:CSTF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GPP0|||http://purl.uniprot.org/uniprot/A0A2I3HDC7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:CMKLR1 ^@ http://purl.uniprot.org/uniprot/G1R4V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:CDCA2 ^@ http://purl.uniprot.org/uniprot/G1S283 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:BCLAF1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HYX0|||http://purl.uniprot.org/uniprot/G1RXM4 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/61853:CLDND2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GEY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/61853:ACOX1 ^@ http://purl.uniprot.org/uniprot/G1QN40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/61853:IL23A ^@ http://purl.uniprot.org/uniprot/G1S6V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/61853:PSME3IP1 ^@ http://purl.uniprot.org/uniprot/G1QQV5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:ICOS ^@ http://purl.uniprot.org/uniprot/G1R5Y2|||http://purl.uniprot.org/uniprot/M3ZA37 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/61853:CXCL14 ^@ http://purl.uniprot.org/uniprot/G1RA03 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/61853:SELL ^@ http://purl.uniprot.org/uniprot/A0A2I3H1K0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the selectin/LECAM family.|||Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.|||Cell membrane|||Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:DEFB108B ^@ http://purl.uniprot.org/uniprot/A0A2I3G9Q9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/61853:ACTL7B ^@ http://purl.uniprot.org/uniprot/G1SBD7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/61853:IL15 ^@ http://purl.uniprot.org/uniprot/G1QZK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/61853:RPS10 ^@ http://purl.uniprot.org/uniprot/A0A2I3GDB0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS10 family. http://togogenome.org/gene/61853:LOC100606612 ^@ http://purl.uniprot.org/uniprot/A0A2I3GP37 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/61853:BDNF ^@ http://purl.uniprot.org/uniprot/G1S855|||http://purl.uniprot.org/uniprot/G1S858 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NGF-beta family.|||During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.|||Monomers and homodimers. Binds to NTRK2/TRKB.|||Secreted http://togogenome.org/gene/61853:PIK3IP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GXK5|||http://purl.uniprot.org/uniprot/G1QWH9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:ATP6 ^@ http://purl.uniprot.org/uniprot/E7EAF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:SLC48A1 ^@ http://purl.uniprot.org/uniprot/G1S8B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HRG family.|||Endosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/61853:LOC100579598 ^@ http://purl.uniprot.org/uniprot/A0A2I3HNK5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:MMP15 ^@ http://purl.uniprot.org/uniprot/G1QT14 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/61853:LOC100590028 ^@ http://purl.uniprot.org/uniprot/G1S1P2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:LOC100604478 ^@ http://purl.uniprot.org/uniprot/A0A2I3HGS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:CAPN10 ^@ http://purl.uniprot.org/uniprot/A0A2I3H7S0 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/61853:PPM1K ^@ http://purl.uniprot.org/uniprot/A0A2I3G1K6 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/61853:FGF11 ^@ http://purl.uniprot.org/uniprot/G1RE41 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/61853:CDR2 ^@ http://purl.uniprot.org/uniprot/G1RNA0 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/61853:NKX3-1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GI44|||http://purl.uniprot.org/uniprot/A0A2I3HD46 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:SPCS2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G2F3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS2 family.|||Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:SLC39A10 ^@ http://purl.uniprot.org/uniprot/G1R502 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:UBE2E1 ^@ http://purl.uniprot.org/uniprot/G1QTP2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/61853:GPR37 ^@ http://purl.uniprot.org/uniprot/G1RNJ1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:RRAGA ^@ http://purl.uniprot.org/uniprot/G1SBF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/61853:ZDHHC1 ^@ http://purl.uniprot.org/uniprot/G1QXH3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/61853:SEMA5A ^@ http://purl.uniprot.org/uniprot/G1RLH1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:PCYOX1L ^@ http://purl.uniprot.org/uniprot/G1RGP0 ^@ Similarity ^@ Belongs to the prenylcysteine oxidase family. http://togogenome.org/gene/61853:BCCIP ^@ http://purl.uniprot.org/uniprot/A0A2I3GXP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCP1 family.|||May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).|||Nucleus|||spindle pole http://togogenome.org/gene/61853:RPL32 ^@ http://purl.uniprot.org/uniprot/A0A2I3GE63 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/61853:H1-5 ^@ http://purl.uniprot.org/uniprot/G1SAW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/61853:RAB9B ^@ http://purl.uniprot.org/uniprot/G1S9N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||phagosome membrane http://togogenome.org/gene/61853:ANKS1B ^@ http://purl.uniprot.org/uniprot/G1R2K3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/61853:SMS ^@ http://purl.uniprot.org/uniprot/G1RG03 ^@ Similarity ^@ Belongs to the spermidine/spermine synthase family. http://togogenome.org/gene/61853:EEF2KMT ^@ http://purl.uniprot.org/uniprot/G1QRW4 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family. http://togogenome.org/gene/61853:PUF60 ^@ http://purl.uniprot.org/uniprot/A0A2I3HMJ8|||http://purl.uniprot.org/uniprot/A0A2I3HPG1|||http://purl.uniprot.org/uniprot/G1QPC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM half pint family.|||Nucleus http://togogenome.org/gene/61853:DCTPP1 ^@ http://purl.uniprot.org/uniprot/G1S118 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Homotetramer.|||Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.|||cytosol http://togogenome.org/gene/61853:INTS7 ^@ http://purl.uniprot.org/uniprot/G1QQY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 7 family.|||Nucleus http://togogenome.org/gene/61853:CBX8 ^@ http://purl.uniprot.org/uniprot/G1QH15 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:HMGB1 ^@ http://purl.uniprot.org/uniprot/G1QIX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/61853:TP53INP2 ^@ http://purl.uniprot.org/uniprot/G1RGG7 ^@ Subcellular Location Annotation ^@ PML body|||autophagosome|||cytosol http://togogenome.org/gene/61853:SLC25A37 ^@ http://purl.uniprot.org/uniprot/G1S1G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/61853:NDUFA8 ^@ http://purl.uniprot.org/uniprot/A0A2I3GUE5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA8 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/61853:MELK ^@ http://purl.uniprot.org/uniprot/A0A2I3HA62|||http://purl.uniprot.org/uniprot/A0A2I3HHF6|||http://purl.uniprot.org/uniprot/A0A2I3HP02|||http://purl.uniprot.org/uniprot/A0A2I3HR93|||http://purl.uniprot.org/uniprot/A0A2I3HZD6|||http://purl.uniprot.org/uniprot/G1QUG2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/61853:SEMA3E ^@ http://purl.uniprot.org/uniprot/G1RXV2 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:LOC100588325 ^@ http://purl.uniprot.org/uniprot/A0A2I3GR57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:RPL39 ^@ http://purl.uniprot.org/uniprot/A0A2I3HQ79 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/61853:ZP1 ^@ http://purl.uniprot.org/uniprot/G1RTB0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZP domain family. ZPB subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Zona pellucida http://togogenome.org/gene/61853:PKIA ^@ http://purl.uniprot.org/uniprot/G1QNA1 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/61853:GJD2 ^@ http://purl.uniprot.org/uniprot/G1RJX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/61853:WNT3A ^@ http://purl.uniprot.org/uniprot/A0A2I3G281 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/61853:RAMP1 ^@ http://purl.uniprot.org/uniprot/G1RJX9 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/61853:LOC100591753 ^@ http://purl.uniprot.org/uniprot/A0A2I3GWD9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:CAVIN4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HSE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/61853:STAG2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HJY3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/61853:AMPD3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HYP7|||http://purl.uniprot.org/uniprot/G1S766 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Homotetramer. http://togogenome.org/gene/61853:LOC100592283 ^@ http://purl.uniprot.org/uniprot/A0A2I3HVH0|||http://purl.uniprot.org/uniprot/G1RAP9|||http://purl.uniprot.org/uniprot/G1RAQ5|||http://purl.uniprot.org/uniprot/G1RAQ6|||http://purl.uniprot.org/uniprot/G1RAR0|||http://purl.uniprot.org/uniprot/G1RAR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/61853:TXNRD2 ^@ http://purl.uniprot.org/uniprot/G1R0R1 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/61853:SPSB1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H020 ^@ Similarity ^@ Belongs to the SPSB family. http://togogenome.org/gene/61853:TAPT1 ^@ http://purl.uniprot.org/uniprot/G1S3I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAPT1 family.|||Membrane http://togogenome.org/gene/61853:LYNX1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HI63 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:USP48 ^@ http://purl.uniprot.org/uniprot/A0A2I3HM89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Nucleus http://togogenome.org/gene/61853:DEFB124 ^@ http://purl.uniprot.org/uniprot/G1REK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/61853:TMEM233 ^@ http://purl.uniprot.org/uniprot/A0A2I3HQG0 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/61853:SERPINA7 ^@ http://purl.uniprot.org/uniprot/G1RTN6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/61853:TACC2 ^@ http://purl.uniprot.org/uniprot/A0A2I3FQS7|||http://purl.uniprot.org/uniprot/A0A2I3GSL0|||http://purl.uniprot.org/uniprot/A0A2I3GVR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACC family.|||centrosome http://togogenome.org/gene/61853:PRL ^@ http://purl.uniprot.org/uniprot/G1QMP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/61853:ZFPM2 ^@ http://purl.uniprot.org/uniprot/G1QV05 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:IL37 ^@ http://purl.uniprot.org/uniprot/A0A2I3H882|||http://purl.uniprot.org/uniprot/A0A2I3H9R0|||http://purl.uniprot.org/uniprot/A0A2I3HKJ9|||http://purl.uniprot.org/uniprot/G1QN29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/61853:FFAR2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HE13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:TRIM71 ^@ http://purl.uniprot.org/uniprot/G1QWN9 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/61853:LMBR1L ^@ http://purl.uniprot.org/uniprot/G1S839 ^@ Similarity ^@ Belongs to the LIMR family. http://togogenome.org/gene/61853:TMEM43 ^@ http://purl.uniprot.org/uniprot/G1QYM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM43 family.|||Membrane http://togogenome.org/gene/61853:CHST10 ^@ http://purl.uniprot.org/uniprot/G1RW41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:SMIM18 ^@ http://purl.uniprot.org/uniprot/G1SBS3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:FAM110C ^@ http://purl.uniprot.org/uniprot/G1RA72 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/61853:IL3 ^@ http://purl.uniprot.org/uniprot/G1RQ11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-3 family.|||Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK.|||Secreted http://togogenome.org/gene/61853:APAF1 ^@ http://purl.uniprot.org/uniprot/G1R2E0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Monomer. Oligomerizes upon binding of cytochrome c and dATP.|||Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. http://togogenome.org/gene/61853:XK ^@ http://purl.uniprot.org/uniprot/G1QJI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/61853:PROK1 ^@ http://purl.uniprot.org/uniprot/G1QTW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/61853:EYA4 ^@ http://purl.uniprot.org/uniprot/A0A2I3H3V5|||http://purl.uniprot.org/uniprot/A0A2I3HF74|||http://purl.uniprot.org/uniprot/G1RX34|||http://purl.uniprot.org/uniprot/G1RX37 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/61853:BEST4 ^@ http://purl.uniprot.org/uniprot/G1RVC1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/61853:SLC25A33 ^@ http://purl.uniprot.org/uniprot/A0A2I3HIK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/61853:IL6 ^@ http://purl.uniprot.org/uniprot/G1S4D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/61853:ADAMTS3 ^@ http://purl.uniprot.org/uniprot/G1R882 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/61853:GRN ^@ http://purl.uniprot.org/uniprot/G1QZT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the granulin family.|||Secreted http://togogenome.org/gene/61853:NFKB1 ^@ http://purl.uniprot.org/uniprot/G1RSM4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/61853:SLC17A3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GTT3|||http://purl.uniprot.org/uniprot/G1QRN3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:KCNK13 ^@ http://purl.uniprot.org/uniprot/A0A2I3HMD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/61853:SNAPC3 ^@ http://purl.uniprot.org/uniprot/G1S768 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAPC3/SRD2 family.|||Nucleus|||Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.|||Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. http://togogenome.org/gene/61853:UBE3A ^@ http://purl.uniprot.org/uniprot/G1QLH8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.|||Nucleus http://togogenome.org/gene/61853:STX2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GGA6|||http://purl.uniprot.org/uniprot/G1RA20 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/61853:GNL2 ^@ http://purl.uniprot.org/uniprot/G1RLM1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.|||GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.|||nucleolus http://togogenome.org/gene/61853:UBE2C ^@ http://purl.uniprot.org/uniprot/A0A2I3HKD6 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/61853:LSM5 ^@ http://purl.uniprot.org/uniprot/G1RZ54 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. http://togogenome.org/gene/61853:MC3R ^@ http://purl.uniprot.org/uniprot/G1SC23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane http://togogenome.org/gene/61853:TMPRSS7 ^@ http://purl.uniprot.org/uniprot/G1QVW4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:SUV39H1 ^@ http://purl.uniprot.org/uniprot/G1R8Q1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.|||Nucleus|||centromere http://togogenome.org/gene/61853:ATP8B1 ^@ http://purl.uniprot.org/uniprot/G1R9K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/61853:ND2 ^@ http://purl.uniprot.org/uniprot/E7EAE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 2 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:GRID1 ^@ http://purl.uniprot.org/uniprot/G1QNV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/61853:HPSE ^@ http://purl.uniprot.org/uniprot/A0A2I3GYF1|||http://purl.uniprot.org/uniprot/G1RCW3|||http://purl.uniprot.org/uniprot/M3ZAM8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/61853:C1QBP ^@ http://purl.uniprot.org/uniprot/A0A2I3HP96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAM33 family.|||Cell membrane http://togogenome.org/gene/61853:NAA38 ^@ http://purl.uniprot.org/uniprot/A0A2I3GM19 ^@ Function|||Similarity|||Subunit ^@ Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.|||Belongs to the snRNP Sm proteins family.|||Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30. http://togogenome.org/gene/61853:ATP6AP2 ^@ http://purl.uniprot.org/uniprot/G1QLK9 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Lysosome membrane|||Membrane|||autophagosome membrane|||clathrin-coated vesicle membrane|||dendritic spine membrane|||synaptic vesicle membrane http://togogenome.org/gene/61853:TPD52L1 ^@ http://purl.uniprot.org/uniprot/A0A2I3G973|||http://purl.uniprot.org/uniprot/A0A2I3GPD5|||http://purl.uniprot.org/uniprot/A0A2I3HD31|||http://purl.uniprot.org/uniprot/A0A2I3HJZ9|||http://purl.uniprot.org/uniprot/A0A2I3HU83|||http://purl.uniprot.org/uniprot/G1RUL0 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/61853:GPR15 ^@ http://purl.uniprot.org/uniprot/G1S9Z1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:OOEP ^@ http://purl.uniprot.org/uniprot/G1QKI2 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/61853:NPSR1 ^@ http://purl.uniprot.org/uniprot/G1RZW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:SULT1B1 ^@ http://purl.uniprot.org/uniprot/G1R7W4 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/61853:IL11RA ^@ http://purl.uniprot.org/uniprot/H9HA20 ^@ Similarity ^@ Belongs to the type I cytokine receptor family. Type 3 subfamily. http://togogenome.org/gene/61853:RRP15 ^@ http://purl.uniprot.org/uniprot/A0A2I3GEH8 ^@ Similarity ^@ Belongs to the RRP15 family. http://togogenome.org/gene/61853:LOC100581301 ^@ http://purl.uniprot.org/uniprot/G1S978 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:ATG4C ^@ http://purl.uniprot.org/uniprot/G1RYH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/61853:STARD3NL ^@ http://purl.uniprot.org/uniprot/A0A2I3H1B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Membrane http://togogenome.org/gene/61853:SAR1A ^@ http://purl.uniprot.org/uniprot/G1RKD3 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/61853:MNAT1 ^@ http://purl.uniprot.org/uniprot/A0A2I3I007|||http://purl.uniprot.org/uniprot/G1RU18 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with CDK7 and cyclin H.|||Nucleus|||Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. http://togogenome.org/gene/61853:AWAT2 ^@ http://purl.uniprot.org/uniprot/G1QIW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/61853:AGAP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HJT6 ^@ Similarity ^@ Belongs to the centaurin gamma-like family. http://togogenome.org/gene/61853:SLC17A8 ^@ http://purl.uniprot.org/uniprot/A0A2I3GWJ1|||http://purl.uniprot.org/uniprot/G1R2F7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:CTBS ^@ http://purl.uniprot.org/uniprot/G1RFY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 18 family.|||Lysosome http://togogenome.org/gene/61853:KCNJ15 ^@ http://purl.uniprot.org/uniprot/A0A2I3HPN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/61853:SLC25A35 ^@ http://purl.uniprot.org/uniprot/G1RFY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/61853:XKR9 ^@ http://purl.uniprot.org/uniprot/G1RKW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/61853:NADK ^@ http://purl.uniprot.org/uniprot/A0A2I3GS68|||http://purl.uniprot.org/uniprot/G1QGY0 ^@ Similarity ^@ Belongs to the NAD kinase family. http://togogenome.org/gene/61853:RPS8 ^@ http://purl.uniprot.org/uniprot/G1RVA5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS8 family. http://togogenome.org/gene/61853:IGF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GG72 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.|||Secreted http://togogenome.org/gene/61853:ACOT13 ^@ http://purl.uniprot.org/uniprot/G1QQ55 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/61853:LOC100607067 ^@ http://purl.uniprot.org/uniprot/G1R624 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.|||cytoskeleton http://togogenome.org/gene/61853:SUMF1 ^@ http://purl.uniprot.org/uniprot/G1QT25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase-modifying factor family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/61853:GRIA4 ^@ http://purl.uniprot.org/uniprot/A0A2I3H1N9|||http://purl.uniprot.org/uniprot/G1R6G6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/61853:LOC100593084 ^@ http://purl.uniprot.org/uniprot/A0A2I3H772 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:KCNE2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GYX8 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/61853:ABCB6 ^@ http://purl.uniprot.org/uniprot/G1RD55 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Homodimer.|||Late endosome membrane|||Lysosome membrane|||Melanosome membrane|||Membrane|||Mitochondrion outer membrane|||extracellular exosome|||multivesicular body membrane http://togogenome.org/gene/61853:SLC6A14 ^@ http://purl.uniprot.org/uniprot/G1RXD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/61853:BTG1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GMZ1 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/61853:PRRX1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HUB8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:CXCL5 ^@ http://purl.uniprot.org/uniprot/G1R8Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/61853:MRGPRX2 ^@ http://purl.uniprot.org/uniprot/W8W3J3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:FZD3 ^@ http://purl.uniprot.org/uniprot/G1S3V5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:TARS3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HKZ5 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/61853:PGM3 ^@ http://purl.uniprot.org/uniprot/A0A2I3GLF9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. http://togogenome.org/gene/61853:GABARAPL1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GN03|||http://purl.uniprot.org/uniprot/A0A2I3HPG5 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/61853:MT1HL1 ^@ http://purl.uniprot.org/uniprot/G1SB16 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/61853:SGTB ^@ http://purl.uniprot.org/uniprot/G1QTU5 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/61853:NOB1 ^@ http://purl.uniprot.org/uniprot/G1R0P6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOB1 family.|||May play a role in mRNA degradation.|||Nucleus http://togogenome.org/gene/61853:EIF3J ^@ http://purl.uniprot.org/uniprot/A0A2I3HVU7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit J family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.|||Cytoplasm|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation. http://togogenome.org/gene/61853:VIRMA ^@ http://purl.uniprot.org/uniprot/M3ZBE6 ^@ Similarity ^@ Belongs to the vir family. http://togogenome.org/gene/61853:EIF4G2 ^@ http://purl.uniprot.org/uniprot/A0A2I3FWW3 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4G family. http://togogenome.org/gene/61853:DBT ^@ http://purl.uniprot.org/uniprot/G1RM86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/61853:SLC16A4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HRF7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:LOC100589631 ^@ http://purl.uniprot.org/uniprot/G1RCN1 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/61853:TUBE1 ^@ http://purl.uniprot.org/uniprot/G1RRA2 ^@ Similarity ^@ Belongs to the tubulin family. http://togogenome.org/gene/61853:TSPAN8 ^@ http://purl.uniprot.org/uniprot/G1QW97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/61853:ADCK2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G7W1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/61853:MAATS1 ^@ http://purl.uniprot.org/uniprot/G1QYU9 ^@ Similarity ^@ Belongs to the CFAP91 family. http://togogenome.org/gene/61853:LRP12 ^@ http://purl.uniprot.org/uniprot/A0A2I3GWF4|||http://purl.uniprot.org/uniprot/G1QUX7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:KCNQ3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HPQ0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/61853:PAPSS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HQ83 ^@ Similarity ^@ In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family. http://togogenome.org/gene/61853:EBF1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HUT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/61853:MGAT5 ^@ http://purl.uniprot.org/uniprot/G1RAF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 18 family.|||Golgi apparatus membrane|||Membrane|||Secreted http://togogenome.org/gene/61853:SEC22C ^@ http://purl.uniprot.org/uniprot/G1R1K0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/61853:TAF5 ^@ http://purl.uniprot.org/uniprot/G1RZ30 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/61853:FAAH ^@ http://purl.uniprot.org/uniprot/G1S3D7 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/61853:PDCL2 ^@ http://purl.uniprot.org/uniprot/G1RB21 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/61853:NRG3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HNB1|||http://purl.uniprot.org/uniprot/A0A2I3HTB7 ^@ Caution|||Similarity ^@ Belongs to the neuregulin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:FAM133B ^@ http://purl.uniprot.org/uniprot/G1RZD1 ^@ Similarity ^@ Belongs to the FAM133 family. http://togogenome.org/gene/61853:F8 ^@ http://purl.uniprot.org/uniprot/G1RWC7 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/61853:LOC100605842 ^@ http://purl.uniprot.org/uniprot/G1SBV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:TMEM33 ^@ http://purl.uniprot.org/uniprot/G1S5Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/61853:NDUFS4 ^@ http://purl.uniprot.org/uniprot/G1RJN1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS4 subunit family.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Mitochondrion inner membrane http://togogenome.org/gene/61853:TET1 ^@ http://purl.uniprot.org/uniprot/G1RM77 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TET family.|||Binds 1 Fe(2+) ion per subunit.|||Chromosome|||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.|||The zinc ions have a structural role. http://togogenome.org/gene/61853:PHB2 ^@ http://purl.uniprot.org/uniprot/G1QYW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Cell membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:UBE2N ^@ http://purl.uniprot.org/uniprot/G1R126 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/61853:FLOT1 ^@ http://purl.uniprot.org/uniprot/G1R0A3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Cell membrane|||Endosome|||Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.|||May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.|||Membrane|||Membrane raft|||caveola http://togogenome.org/gene/61853:NEK6 ^@ http://purl.uniprot.org/uniprot/A0A2I3HIH7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:ADGRA3 ^@ http://purl.uniprot.org/uniprot/G1S489 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/61853:POLR3GL ^@ http://purl.uniprot.org/uniprot/G1R1F5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/61853:MGP ^@ http://purl.uniprot.org/uniprot/G1QV38|||http://purl.uniprot.org/uniprot/G1QV40 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.|||Belongs to the osteocalcin/matrix Gla protein family.|||Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.|||Requires vitamin K-dependent gamma-carboxylation for its function.|||Secreted http://togogenome.org/gene/61853:SFXN5 ^@ http://purl.uniprot.org/uniprot/A0A2I3HN83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/61853:MFAP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3HR20 ^@ Function|||Similarity ^@ Belongs to the MFAP1 family.|||Involved in pre-mRNA splicing as a component of the spliceosome. http://togogenome.org/gene/61853:CDC42EP3 ^@ http://purl.uniprot.org/uniprot/A0A2I3H8X7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/61853:PTPN22 ^@ http://purl.uniprot.org/uniprot/A0A2I3GX42|||http://purl.uniprot.org/uniprot/A0A2I3H554|||http://purl.uniprot.org/uniprot/G1QX52 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. http://togogenome.org/gene/61853:NXF3 ^@ http://purl.uniprot.org/uniprot/G1R7P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NXF family.|||Cytoplasm http://togogenome.org/gene/61853:LOC100603596 ^@ http://purl.uniprot.org/uniprot/G1SCB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:PLEKHA8 ^@ http://purl.uniprot.org/uniprot/A0A2I3HRS6 ^@ Subcellular Location Annotation ^@ trans-Golgi network membrane http://togogenome.org/gene/61853:NAPG ^@ http://purl.uniprot.org/uniprot/A0A2I3GQH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/61853:RTN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3G3F8|||http://purl.uniprot.org/uniprot/G1QXF0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:PRPF18 ^@ http://purl.uniprot.org/uniprot/G1RNI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP18 family.|||Nucleus speckle http://togogenome.org/gene/61853:LOC100581935 ^@ http://purl.uniprot.org/uniprot/A0A2I3GL97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PET117 family.|||Mitochondrion http://togogenome.org/gene/61853:PLK2 ^@ http://purl.uniprot.org/uniprot/G1QQ83 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/61853:CNN3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HF96 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/61853:SDHD ^@ http://purl.uniprot.org/uniprot/A0A2I3H5U8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CybS family.|||Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/61853:UBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GVW1|||http://purl.uniprot.org/uniprot/G1QXJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/61853:RELN ^@ http://purl.uniprot.org/uniprot/G1RD90 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the reelin family.|||Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Oligomer of disulfide-linked homodimers. Binds to the ectodomains of VLDLR and LRP8/APOER2.|||extracellular matrix http://togogenome.org/gene/61853:DNAJA1 ^@ http://purl.uniprot.org/uniprot/G1QZM9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:LOC100590761 ^@ http://purl.uniprot.org/uniprot/A0A2I3G353|||http://purl.uniprot.org/uniprot/A0A2I3GYN4|||http://purl.uniprot.org/uniprot/A0A2I3GZY8|||http://purl.uniprot.org/uniprot/A0A2I3H7X2|||http://purl.uniprot.org/uniprot/A0A2I3HCM0|||http://purl.uniprot.org/uniprot/A0A2I3HYW1|||http://purl.uniprot.org/uniprot/G1SA29 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/61853:PSIP1 ^@ http://purl.uniprot.org/uniprot/G1S757 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HDGF family.|||Nucleus http://togogenome.org/gene/61853:B3GLCT ^@ http://purl.uniprot.org/uniprot/G1QJC3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:C2H5orf63 ^@ http://purl.uniprot.org/uniprot/G1RNT2 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/61853:GORASP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HGY7 ^@ Similarity ^@ Belongs to the GORASP family. http://togogenome.org/gene/61853:FMO4 ^@ http://purl.uniprot.org/uniprot/G1RYU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/61853:TREH ^@ http://purl.uniprot.org/uniprot/A0A2I3GQI6|||http://purl.uniprot.org/uniprot/G1R719 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 37 family. http://togogenome.org/gene/61853:BCAP31 ^@ http://purl.uniprot.org/uniprot/G1RSQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||Membrane|||Plays a role in the export of secreted proteins in the ER. http://togogenome.org/gene/61853:SAP130 ^@ http://purl.uniprot.org/uniprot/A0A2I3FVT6|||http://purl.uniprot.org/uniprot/G1S158 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAP130 family.|||Nucleus http://togogenome.org/gene/61853:SLC18A2 ^@ http://purl.uniprot.org/uniprot/G1S3N7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:KDM6A ^@ http://purl.uniprot.org/uniprot/A0A2I3GAP5|||http://purl.uniprot.org/uniprot/A0A2I3GJQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTX family.|||Nucleus http://togogenome.org/gene/61853:DDX59 ^@ http://purl.uniprot.org/uniprot/G1S8W5 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX59 subfamily. http://togogenome.org/gene/61853:BRS3 ^@ http://purl.uniprot.org/uniprot/G1QQU1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with C6orf89.|||Membrane http://togogenome.org/gene/61853:PAH ^@ http://purl.uniprot.org/uniprot/G1R3M2 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/61853:KPNA1 ^@ http://purl.uniprot.org/uniprot/G1QHH2 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/61853:SMIM7 ^@ http://purl.uniprot.org/uniprot/A0A2I3H1M6 ^@ Similarity ^@ Belongs to the SMIM7 family. http://togogenome.org/gene/61853:SELP ^@ http://purl.uniprot.org/uniprot/G1RYC2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selectin/LECAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:PRDX6 ^@ http://purl.uniprot.org/uniprot/A0A2I3GFG1 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/61853:LOC100595460 ^@ http://purl.uniprot.org/uniprot/G1RKL1 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/61853:DRD3 ^@ http://purl.uniprot.org/uniprot/A0A2I3G112|||http://purl.uniprot.org/uniprot/G1QXU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.|||Membrane http://togogenome.org/gene/61853:HAUS1 ^@ http://purl.uniprot.org/uniprot/G1RKA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS1 family.|||spindle http://togogenome.org/gene/61853:SPAM1 ^@ http://purl.uniprot.org/uniprot/G1RNI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 56 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:BTG2 ^@ http://purl.uniprot.org/uniprot/A0A2I3FTC7 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/61853:GTPBP4 ^@ http://purl.uniprot.org/uniprot/A0A2I3HCH0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/61853:PIGK ^@ http://purl.uniprot.org/uniprot/G1REU3 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C13 family.|||Forms a complex with PIGT, PIGS, PIGU and GAA1. http://togogenome.org/gene/61853:ALG2 ^@ http://purl.uniprot.org/uniprot/G1S5C1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.|||Membrane http://togogenome.org/gene/61853:HMGCS1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GM62 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/61853:SGK2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G2D9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:ADAMTS1 ^@ http://purl.uniprot.org/uniprot/G1QR38 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/61853:RSL24D1 ^@ http://purl.uniprot.org/uniprot/G1R489 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/61853:B3GAT2 ^@ http://purl.uniprot.org/uniprot/G1QJQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:OAZ2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G823 ^@ Similarity ^@ Belongs to the ODC antizyme family. http://togogenome.org/gene/61853:SRFBP1 ^@ http://purl.uniprot.org/uniprot/G1RMR5 ^@ Function|||Subunit ^@ Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.|||May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells. http://togogenome.org/gene/61853:EHD1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GDQ0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/61853:HRK ^@ http://purl.uniprot.org/uniprot/G1QHD8 ^@ Function|||Subcellular Location Annotation ^@ Mitochondrion|||Promotes apoptosis. http://togogenome.org/gene/61853:SH3BP5 ^@ http://purl.uniprot.org/uniprot/G1QM43 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SH3BP5 family.|||Cytoplasm|||Functions as guanine nucleotide exchange factor (GEF) for RAB11A.|||Interacts with GDP-bound and nucleotide-free forms of RAB11A.|||The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape. http://togogenome.org/gene/61853:OTOP2 ^@ http://purl.uniprot.org/uniprot/G1QI62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:PTP4A2 ^@ http://purl.uniprot.org/uniprot/A0A2I3FQQ1 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/61853:ALG14 ^@ http://purl.uniprot.org/uniprot/G1RK94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG14 family.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane http://togogenome.org/gene/61853:POMK ^@ http://purl.uniprot.org/uniprot/G1RR88 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif. http://togogenome.org/gene/61853:SPIN4 ^@ http://purl.uniprot.org/uniprot/G1SAK0 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/61853:PYGL ^@ http://purl.uniprot.org/uniprot/G1RP19 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/61853:KREMEN1 ^@ http://purl.uniprot.org/uniprot/G1QQB8 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. http://togogenome.org/gene/61853:PIPOX ^@ http://purl.uniprot.org/uniprot/G1QSK9 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/61853:NCK1 ^@ http://purl.uniprot.org/uniprot/G1QVI6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/61853:DESI1 ^@ http://purl.uniprot.org/uniprot/G1S096 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/61853:KATNAL2 ^@ http://purl.uniprot.org/uniprot/A0A2I3G6M6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.|||Cytoplasm|||Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/61853:AQP2 ^@ http://purl.uniprot.org/uniprot/G1S800 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/61853:ENTPD7 ^@ http://purl.uniprot.org/uniprot/A0A2I3HI29 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/61853:MPV17 ^@ http://purl.uniprot.org/uniprot/G1QSP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/61853:CD37 ^@ http://purl.uniprot.org/uniprot/A0A2I3G0K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/61853:C10H12orf65 ^@ http://purl.uniprot.org/uniprot/G1QLA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/61853:SLC35E4 ^@ http://purl.uniprot.org/uniprot/G1QV24 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:FAM216B ^@ http://purl.uniprot.org/uniprot/A0A2I3H932 ^@ Similarity ^@ Belongs to the FAM216 family. http://togogenome.org/gene/61853:MTMR7 ^@ http://purl.uniprot.org/uniprot/G1QQL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/61853:TMEM87A ^@ http://purl.uniprot.org/uniprot/G1QVV2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:IL1RL2 ^@ http://purl.uniprot.org/uniprot/G1RX28 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/61853:TPRG1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GTK2 ^@ Similarity ^@ Belongs to the TPRG1 family. http://togogenome.org/gene/61853:TAF13 ^@ http://purl.uniprot.org/uniprot/G1QPF7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:C1RL ^@ http://purl.uniprot.org/uniprot/G1QZ62 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:LOC100579903 ^@ http://purl.uniprot.org/uniprot/A0A2I3HJM3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIIc family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:TMC5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GBZ8|||http://purl.uniprot.org/uniprot/A0A2I3HDF9|||http://purl.uniprot.org/uniprot/A0A2I3HX68|||http://purl.uniprot.org/uniprot/G1R001 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/61853:BOLA2B ^@ http://purl.uniprot.org/uniprot/A0A2I3GLW4 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/61853:XPNPEP1 ^@ http://purl.uniprot.org/uniprot/A0A2I3H708 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/61853:LOC100602990 ^@ http://purl.uniprot.org/uniprot/A0A2I3GGW8 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/61853:DHX29 ^@ http://purl.uniprot.org/uniprot/G1QLC3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.|||Belongs to the DEAD box helicase family. DEAH subfamily.|||Cytoplasm|||Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit. http://togogenome.org/gene/61853:SPTY2D1 ^@ http://purl.uniprot.org/uniprot/G1S7V8 ^@ Similarity ^@ Belongs to the SPT2 family. http://togogenome.org/gene/61853:ALKBH6 ^@ http://purl.uniprot.org/uniprot/G1RLP2 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/61853:PDE4B ^@ http://purl.uniprot.org/uniprot/A0A2I3GA09|||http://purl.uniprot.org/uniprot/A0A2I3GLK0|||http://purl.uniprot.org/uniprot/A0A2I3HRD9 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/61853:INPP1 ^@ http://purl.uniprot.org/uniprot/G1R4H8 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/61853:TGFBI ^@ http://purl.uniprot.org/uniprot/G1RAG7 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/61853:ALB ^@ http://purl.uniprot.org/uniprot/A0A2I3H4J6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/61853:EGR3 ^@ http://purl.uniprot.org/uniprot/G1S103 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/61853:TSPAN1 ^@ http://purl.uniprot.org/uniprot/G1S3V1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/61853:CAST ^@ http://purl.uniprot.org/uniprot/A0A2I3GGL8|||http://purl.uniprot.org/uniprot/A0A2I3GRS9 ^@ Function|||Similarity ^@ Belongs to the protease inhibitor I27 (calpastatin) family.|||Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. http://togogenome.org/gene/61853:LOC100593228 ^@ http://purl.uniprot.org/uniprot/A0A2I3HNU0|||http://purl.uniprot.org/uniprot/G1QVD1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:PI4K2A ^@ http://purl.uniprot.org/uniprot/G1RVM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.|||Membrane http://togogenome.org/gene/61853:TNNT2 ^@ http://purl.uniprot.org/uniprot/G1S8X4 ^@ Function|||Similarity ^@ Belongs to the troponin T family.|||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/61853:SLC7A13 ^@ http://purl.uniprot.org/uniprot/A0A2I3HJ49|||http://purl.uniprot.org/uniprot/G1QLF7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:SAA2 ^@ http://purl.uniprot.org/uniprot/G1S7R0 ^@ Function|||Similarity ^@ Belongs to the SAA family.|||Major acute phase reactant. Apolipoprotein of the HDL complex. http://togogenome.org/gene/61853:YIPF4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GRI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:SRXN1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GA43 ^@ Similarity ^@ Belongs to the sulfiredoxin family. http://togogenome.org/gene/61853:MICAL3 ^@ http://purl.uniprot.org/uniprot/G1R8P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mical family.|||Cytoplasm http://togogenome.org/gene/61853:POLR2L ^@ http://purl.uniprot.org/uniprot/G1RBJ6 ^@ Similarity ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family. http://togogenome.org/gene/61853:C2H16orf87 ^@ http://purl.uniprot.org/uniprot/G1S0H9 ^@ Similarity ^@ Belongs to the UPF0547 family. http://togogenome.org/gene/61853:SMARCD2 ^@ http://purl.uniprot.org/uniprot/G1QVN7 ^@ Similarity ^@ Belongs to the SMARCD family. http://togogenome.org/gene/61853:CAV1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GLN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/61853:SLC10A4 ^@ http://purl.uniprot.org/uniprot/G1S6H8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/61853:ATF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GRA9|||http://purl.uniprot.org/uniprot/A0A2I3HRN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Binds DNA as a dimer and can form a homodimer in the absence of DNA.|||Nucleus|||Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). http://togogenome.org/gene/61853:TRNAU1AP ^@ http://purl.uniprot.org/uniprot/G1RFG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TRSPAP family.|||Cytoplasm|||Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.|||Nucleus http://togogenome.org/gene/61853:GSTZ1 ^@ http://purl.uniprot.org/uniprot/G1S452 ^@ Similarity ^@ Belongs to the GST superfamily. Zeta family. http://togogenome.org/gene/61853:CCNB2 ^@ http://purl.uniprot.org/uniprot/G1RLG5 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/61853:RXFP1 ^@ http://purl.uniprot.org/uniprot/G1R3I9 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/61853:MEOX2 ^@ http://purl.uniprot.org/uniprot/G1S2X0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:PDIK1L ^@ http://purl.uniprot.org/uniprot/G1RD92 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:SSX2IP ^@ http://purl.uniprot.org/uniprot/M3Z9S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIP family.|||adherens junction|||centriolar satellite http://togogenome.org/gene/61853:LOC100586250 ^@ http://purl.uniprot.org/uniprot/A0A2I3H9B6 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/61853:PLPP5 ^@ http://purl.uniprot.org/uniprot/A0A2I3HDK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/61853:STK38 ^@ http://purl.uniprot.org/uniprot/G1RIH6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/61853:LOC100595691 ^@ http://purl.uniprot.org/uniprot/A0A2I3GKR0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:NAT10 ^@ http://purl.uniprot.org/uniprot/G1S8D0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.|||Interacts with THUMPD1.|||RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.|||nucleolus http://togogenome.org/gene/61853:ITIH2 ^@ http://purl.uniprot.org/uniprot/G1RMH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/61853:SNRPD2 ^@ http://purl.uniprot.org/uniprot/G1QP64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.|||cytosol http://togogenome.org/gene/61853:WDFY1 ^@ http://purl.uniprot.org/uniprot/G1RF30 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/61853:SEC24D ^@ http://purl.uniprot.org/uniprot/G1RCH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/61853:RBFOX2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBJ5|||http://purl.uniprot.org/uniprot/A0A2I3HJ98 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||RNA-binding protein that regulates alternative splicing events. http://togogenome.org/gene/61853:LOC100596110 ^@ http://purl.uniprot.org/uniprot/G1R6W7 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/61853:GNA14 ^@ http://purl.uniprot.org/uniprot/G1QR95 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/61853:PDE6C ^@ http://purl.uniprot.org/uniprot/G1RQW6 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/61853:CLPS ^@ http://purl.uniprot.org/uniprot/A0A2I3GYE7|||http://purl.uniprot.org/uniprot/G1RBW5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.|||Enterostatin has a biological activity as a satiety signal.|||Forms a 1:1 stoichiometric complex with pancreatic lipase.|||Secreted http://togogenome.org/gene/61853:NSG2 ^@ http://purl.uniprot.org/uniprot/G1QI84 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/61853:EGF ^@ http://purl.uniprot.org/uniprot/A0A2I3GH31|||http://purl.uniprot.org/uniprot/A0A2I3HAR9|||http://purl.uniprot.org/uniprot/G1S3J7 ^@ Caution|||Function|||Subunit ^@ EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.|||Interacts with EGFR and promotes EGFR dimerization.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/61853:GPR39 ^@ http://purl.uniprot.org/uniprot/G1RA66 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/61853:SLC12A6 ^@ http://purl.uniprot.org/uniprot/A0A2I3FY94|||http://purl.uniprot.org/uniprot/A0A2I3GV01|||http://purl.uniprot.org/uniprot/A0A2I3HZ52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/61853:SENP6 ^@ http://purl.uniprot.org/uniprot/G1QYW4 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/61853:LOC100586435 ^@ http://purl.uniprot.org/uniprot/M3ZA25 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/61853:KCNJ3 ^@ http://purl.uniprot.org/uniprot/A0A2I3HCJ3|||http://purl.uniprot.org/uniprot/G1RKZ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.|||Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.|||Membrane|||This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. http://togogenome.org/gene/61853:DDX10 ^@ http://purl.uniprot.org/uniprot/G1R6L2 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/61853:TOP1 ^@ http://purl.uniprot.org/uniprot/G1R3V8 ^@ Function|||Similarity ^@ Belongs to the type IB topoisomerase family.|||Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/61853:CTSH ^@ http://purl.uniprot.org/uniprot/G1RBY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/61853:PLA2G4F ^@ http://purl.uniprot.org/uniprot/G1QVK3 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/61853:PALM2AKAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GQK4 ^@ Similarity ^@ Belongs to the paralemmin family. http://togogenome.org/gene/61853:TBC1D24 ^@ http://purl.uniprot.org/uniprot/G1RE02 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasmic vesicle membrane|||Interacts with ARF6.|||Membrane|||Presynapse http://togogenome.org/gene/61853:INHBC ^@ http://purl.uniprot.org/uniprot/G1S6B8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/61853:ZACN ^@ http://purl.uniprot.org/uniprot/G1QNM8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/61853:USB1 ^@ http://purl.uniprot.org/uniprot/G1QSX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2H phosphoesterase superfamily. USB1 family.|||Nucleus|||Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. http://togogenome.org/gene/61853:JAKMIP2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GDX8|||http://purl.uniprot.org/uniprot/A0A2I3HWA0 ^@ Similarity ^@ Belongs to the JAKMIP family. http://togogenome.org/gene/61853:IFNL1 ^@ http://purl.uniprot.org/uniprot/G1RWJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lambda interferon family.|||Secreted http://togogenome.org/gene/61853:DUSP5 ^@ http://purl.uniprot.org/uniprot/A0A2I3HMF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/61853:GRPR ^@ http://purl.uniprot.org/uniprot/G1REB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:ND5 ^@ http://purl.uniprot.org/uniprot/S4UWB8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 5 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/61853:TASP1 ^@ http://purl.uniprot.org/uniprot/G1RWS8 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/61853:GADL1 ^@ http://purl.uniprot.org/uniprot/G1QVT3 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/61853:LOC100588156 ^@ http://purl.uniprot.org/uniprot/G1SBG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:OIP5 ^@ http://purl.uniprot.org/uniprot/A0A2I3GI92 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.|||centromere http://togogenome.org/gene/61853:IFNW1 ^@ http://purl.uniprot.org/uniprot/A0A7R8C4W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/61853:MTRF1 ^@ http://purl.uniprot.org/uniprot/G1QKP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/61853:GNA12 ^@ http://purl.uniprot.org/uniprot/A0A2I3G8L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-alpha family. G(12) subfamily.|||Membrane http://togogenome.org/gene/61853:ACE2 ^@ http://purl.uniprot.org/uniprot/G1RE79 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M2 family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Cytoplasm|||Membrane|||Secreted|||cilium http://togogenome.org/gene/61853:SEC13 ^@ http://purl.uniprot.org/uniprot/G1QWZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Lysosome membrane http://togogenome.org/gene/61853:GCH1 ^@ http://purl.uniprot.org/uniprot/G1RQH2 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I family. http://togogenome.org/gene/61853:NDNF ^@ http://purl.uniprot.org/uniprot/A0A2I3H8G6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/61853:REM1 ^@ http://purl.uniprot.org/uniprot/G1REL0 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/61853:EXOG ^@ http://purl.uniprot.org/uniprot/A0A2I3GX86|||http://purl.uniprot.org/uniprot/G1R046 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/61853:SVBP ^@ http://purl.uniprot.org/uniprot/G1RP16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVBP family.|||Secreted|||cytoskeleton http://togogenome.org/gene/61853:MDH1B ^@ http://purl.uniprot.org/uniprot/G1R648 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family. http://togogenome.org/gene/61853:C15H11orf1 ^@ http://purl.uniprot.org/uniprot/A0A2I3GUT1|||http://purl.uniprot.org/uniprot/G1R6Q7 ^@ Function|||Subcellular Location Annotation ^@ Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.|||cilium axoneme http://togogenome.org/gene/61853:MAOB ^@ http://purl.uniprot.org/uniprot/G1QPV3 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/61853:SETD6 ^@ http://purl.uniprot.org/uniprot/A0A2I3GJ66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.|||Nucleus|||Protein-lysine N-methyltransferase. http://togogenome.org/gene/61853:DNTT ^@ http://purl.uniprot.org/uniprot/G1RSJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Nucleus|||Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. http://togogenome.org/gene/61853:ANXA3 ^@ http://purl.uniprot.org/uniprot/G1RAG3 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/61853:GALNT11 ^@ http://purl.uniprot.org/uniprot/G1QXD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/61853:BMT2 ^@ http://purl.uniprot.org/uniprot/G1RKR8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the BMT2 family.|||Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.|||S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/61853:SPI1 ^@ http://purl.uniprot.org/uniprot/G1RWT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/61853:CHRNB2 ^@ http://purl.uniprot.org/uniprot/G1RL13 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/61853:G6PC2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GZ03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/61853:TMEM231 ^@ http://purl.uniprot.org/uniprot/G1RRG1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM231 family.|||Membrane|||Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.|||cilium membrane http://togogenome.org/gene/61853:LOC100583243 ^@ http://purl.uniprot.org/uniprot/A0A2I3HBL3 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/61853:PAGE1 ^@ http://purl.uniprot.org/uniprot/G1R9I5 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/61853:MRPL16 ^@ http://purl.uniprot.org/uniprot/G1RRR1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/61853:NR3C1 ^@ http://purl.uniprot.org/uniprot/M3ZBD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Mitochondrion|||Nucleus|||centrosome|||spindle http://togogenome.org/gene/61853:LOC100604165 ^@ http://purl.uniprot.org/uniprot/G1R2G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/61853:HOMEZ ^@ http://purl.uniprot.org/uniprot/A0A2I3HNI3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:SIAH2 ^@ http://purl.uniprot.org/uniprot/G1QSY7 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/61853:PI4KA ^@ http://purl.uniprot.org/uniprot/G1QH25 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/61853:PLA2G2A ^@ http://purl.uniprot.org/uniprot/G1R8T6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/61853:IGFBP5 ^@ http://purl.uniprot.org/uniprot/G1R6Q6 ^@ Caution|||Function|||Subcellular Location Annotation ^@ IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/61853:RPF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3HLG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/61853:PABPC4 ^@ http://purl.uniprot.org/uniprot/A0A2I3GCJ7|||http://purl.uniprot.org/uniprot/G1RMR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/61853:SRRD ^@ http://purl.uniprot.org/uniprot/G1R870 ^@ Similarity ^@ Belongs to the SRR1 family. http://togogenome.org/gene/61853:CNOT7 ^@ http://purl.uniprot.org/uniprot/G1QQ61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/61853:PIGO ^@ http://purl.uniprot.org/uniprot/A0A2I3GAK0|||http://purl.uniprot.org/uniprot/G1QXF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:C18H16orf91 ^@ http://purl.uniprot.org/uniprot/A0A2I3G2M7 ^@ Similarity ^@ Belongs to the UQCC4 family. http://togogenome.org/gene/61853:NOL10 ^@ http://purl.uniprot.org/uniprot/A0A2I3I044 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat NOL10/ENP2 family.|||nucleolus http://togogenome.org/gene/61853:LOC100585672 ^@ http://purl.uniprot.org/uniprot/A0A2I3H820 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/61853:GHITM ^@ http://purl.uniprot.org/uniprot/A0A2I3G315 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/61853:ACVR1 ^@ http://purl.uniprot.org/uniprot/G1QJA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/61853:TMEM198 ^@ http://purl.uniprot.org/uniprot/G1REE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM198 family.|||Membrane http://togogenome.org/gene/61853:SNX14 ^@ http://purl.uniprot.org/uniprot/A0A2I3GGM8 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/61853:STIM1 ^@ http://purl.uniprot.org/uniprot/G1S685 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/61853:RPL37 ^@ http://purl.uniprot.org/uniprot/A0A2I3GWN4 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/61853:ZSCAN30 ^@ http://purl.uniprot.org/uniprot/A0A2I3HVL0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/61853:GABRB2 ^@ http://purl.uniprot.org/uniprot/A0A2I4HY33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/61853:ZFYVE27 ^@ http://purl.uniprot.org/uniprot/A0A2I3G838|||http://purl.uniprot.org/uniprot/G1RVW7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Recycling endosome membrane|||growth cone membrane http://togogenome.org/gene/61853:RGMB ^@ http://purl.uniprot.org/uniprot/G1RWJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Membrane http://togogenome.org/gene/61853:RAPGEF2 ^@ http://purl.uniprot.org/uniprot/A0A2I3GDC5|||http://purl.uniprot.org/uniprot/A0A2I3GT96 ^@ Similarity ^@ Belongs to the RAPGEF2 family.