http://togogenome.org/gene/6238:CBG_20584 ^@ http://purl.uniprot.org/uniprot/A8XY51 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6238:CBG_14467 ^@ http://purl.uniprot.org/uniprot/A8XK04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cell membrane|||coated pit http://togogenome.org/gene/6238:CBG_03136 ^@ http://purl.uniprot.org/uniprot/A8WSQ2 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/6238:CBG_22510 ^@ http://purl.uniprot.org/uniprot/A8Y2F7 ^@ Similarity ^@ Belongs to the SHQ1 family.|||Belongs to the peptidase C48 family. http://togogenome.org/gene/6238:CBG_19337 ^@ http://purl.uniprot.org/uniprot/A8XVE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/6238:CBG_04100 ^@ http://purl.uniprot.org/uniprot/A8WW77 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_11351 ^@ http://purl.uniprot.org/uniprot/A8XD79 ^@ Similarity ^@ Belongs to the glycosyltransferase 92 family. http://togogenome.org/gene/6238:CBG_11415 ^@ http://purl.uniprot.org/uniprot/A8XD29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DXO/Dom3Z family.|||Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.|||Nucleus http://togogenome.org/gene/6238:CBG_12909 ^@ http://purl.uniprot.org/uniprot/A8XGN1 ^@ Similarity ^@ Belongs to the CDK5RAP3 family. http://togogenome.org/gene/6238:CBG_13234 ^@ http://purl.uniprot.org/uniprot/A8XHD1 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/6238:CBG_10043 ^@ http://purl.uniprot.org/uniprot/A8XA88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/6238:CBG_16284 ^@ http://purl.uniprot.org/uniprot/A8XNR1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6238:CBG_01498 ^@ http://purl.uniprot.org/uniprot/A8WQJ8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_19329 ^@ http://purl.uniprot.org/uniprot/A8XVD4 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_05065 ^@ http://purl.uniprot.org/uniprot/A8WZ34 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/6238:CBG_14484 ^@ http://purl.uniprot.org/uniprot/Q1M2W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/6238:CBG_01701 ^@ http://purl.uniprot.org/uniprot/A8WR19 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/6238:CBG_21048 ^@ http://purl.uniprot.org/uniprot/A8XZB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase inhibitor family.|||Mitochondrion|||Thought to be a regulatory component of the ATP-synthesizing complex in the mitochondria. http://togogenome.org/gene/6238:CBG_19336 ^@ http://purl.uniprot.org/uniprot/A8XVE0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/6238:CBG_03160 ^@ http://purl.uniprot.org/uniprot/A8WSN2 ^@ Similarity ^@ Belongs to the SAS10 family. http://togogenome.org/gene/6238:CBG_11156 ^@ http://purl.uniprot.org/uniprot/A8XCK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Late endosome membrane|||Membrane http://togogenome.org/gene/6238:CBG_15314 ^@ http://purl.uniprot.org/uniprot/A8XLX2 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/6238:CBG_04579 ^@ http://purl.uniprot.org/uniprot/A8WXZ3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/6238:CBG_18276 ^@ http://purl.uniprot.org/uniprot/A8XSB4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_20834 ^@ http://purl.uniprot.org/uniprot/Q60SM4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).|||Nucleus http://togogenome.org/gene/6238:CBG_07863 ^@ http://purl.uniprot.org/uniprot/A8X5A8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/6238:CBG_06285 ^@ http://purl.uniprot.org/uniprot/A8X1V5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_02576 ^@ http://purl.uniprot.org/uniprot/A8WU03 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_22795 ^@ http://purl.uniprot.org/uniprot/A8Y2W5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.|||Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_16247 ^@ http://purl.uniprot.org/uniprot/A8XNT7 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer. http://togogenome.org/gene/6238:CBG_22372 ^@ http://purl.uniprot.org/uniprot/Q60P81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL18 family.|||Cytoplasm http://togogenome.org/gene/6238:CBG_14935 ^@ http://purl.uniprot.org/uniprot/A8XL15 ^@ Similarity ^@ Belongs to the maelstrom family. http://togogenome.org/gene/6238:CBG_23399 ^@ http://purl.uniprot.org/uniprot/Q60LW7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity).|||Component of the elongator complex.|||The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification. http://togogenome.org/gene/6238:CBG_19114 ^@ http://purl.uniprot.org/uniprot/G2J6Y9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KRR1 family.|||Component of the ribosomal small subunit (SSU) processome.|||Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.|||nucleolus http://togogenome.org/gene/6238:CBG_22173 ^@ http://purl.uniprot.org/uniprot/A8Y1Q5 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.|||The WWE domain mediates non-covalent poly(ADP-ribose)-binding.|||Ubiquitinated; autoubiquitinated.|||cytosol http://togogenome.org/gene/6238:CBG_01780 ^@ http://purl.uniprot.org/uniprot/A8WQU8 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/6238:CBG_03644 ^@ http://purl.uniprot.org/uniprot/A8WVI2 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/6238:CBG_12661 ^@ http://purl.uniprot.org/uniprot/A8XGA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INP1 family.|||Membrane|||Peroxisome membrane|||Required for peroxisome inheritance. http://togogenome.org/gene/6238:CBG_15347 ^@ http://purl.uniprot.org/uniprot/A8XM01 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. http://togogenome.org/gene/6238:CBG_17072 ^@ http://purl.uniprot.org/uniprot/A8XQF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_02686 ^@ http://purl.uniprot.org/uniprot/A8WTR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/6238:CBG_12466 ^@ http://purl.uniprot.org/uniprot/Q61DI9 ^@ Function|||Similarity ^@ Belongs to the archease family.|||Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RtcB. http://togogenome.org/gene/6238:CBG_21104 ^@ http://purl.uniprot.org/uniprot/A8XZG9 ^@ Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. http://togogenome.org/gene/6238:CBG_01620 ^@ http://purl.uniprot.org/uniprot/A8WR83 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_03669 ^@ http://purl.uniprot.org/uniprot/A8WVK0 ^@ Similarity ^@ Belongs to the U2 small nuclear ribonucleoprotein A family. http://togogenome.org/gene/6238:CBG_00670 ^@ http://purl.uniprot.org/uniprot/A8WNB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/6238:CBG_01640 ^@ http://purl.uniprot.org/uniprot/A8WR67 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_12181 ^@ http://purl.uniprot.org/uniprot/A8XF20 ^@ Similarity ^@ Belongs to the XPF family. http://togogenome.org/gene/6238:CBG_22875 ^@ http://purl.uniprot.org/uniprot/A8Y397 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_06635 ^@ http://purl.uniprot.org/uniprot/A8X2Q3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_15156 ^@ http://purl.uniprot.org/uniprot/A8XLT5 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/6238:CBG_08750 ^@ http://purl.uniprot.org/uniprot/A8X7B0 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/6238:CBG_17083 ^@ http://purl.uniprot.org/uniprot/A8XQF2 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/6238:CBG_13252 ^@ http://purl.uniprot.org/uniprot/A8XHE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/6238:CBG_05925 ^@ http://purl.uniprot.org/uniprot/A8X1B6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_15416 ^@ http://purl.uniprot.org/uniprot/A8XMB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Nucleus http://togogenome.org/gene/6238:CBG_14716 ^@ http://purl.uniprot.org/uniprot/A8XKI5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_02884 ^@ http://purl.uniprot.org/uniprot/Q620A6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_09387 ^@ http://purl.uniprot.org/uniprot/A8X976 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/6238:CBG_10424 ^@ http://purl.uniprot.org/uniprot/A8XB65 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_17662 ^@ http://purl.uniprot.org/uniprot/A8XRL0 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_12983 ^@ http://purl.uniprot.org/uniprot/A8XGT9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_04630 ^@ http://purl.uniprot.org/uniprot/A8WY38 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/6238:CBG_02637 ^@ http://purl.uniprot.org/uniprot/A8WTV1 ^@ Similarity ^@ Belongs to the Asterix family. http://togogenome.org/gene/6238:CBG_04066 ^@ http://purl.uniprot.org/uniprot/A8WW49 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSRP1 family.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Nucleus http://togogenome.org/gene/6238:CBG_23380 ^@ http://purl.uniprot.org/uniprot/A8Y421 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_02284 ^@ http://purl.uniprot.org/uniprot/A8WUP5 ^@ Similarity ^@ Belongs to the SURF6 family. http://togogenome.org/gene/6238:CBG_06825 ^@ http://purl.uniprot.org/uniprot/A8X357 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GST superfamily. Pi family.|||Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.|||Homodimer. http://togogenome.org/gene/6238:CBG_05893 ^@ http://purl.uniprot.org/uniprot/A8X1E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/6238:CBG_24273 ^@ http://purl.uniprot.org/uniprot/A8WKC7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/6238:CBG_23121 ^@ http://purl.uniprot.org/uniprot/A8Y4N2 ^@ Caution|||Similarity ^@ Belongs to the nematode receptor-like protein srg family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_11589 ^@ http://purl.uniprot.org/uniprot/A8XDK5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/6238:CBG_19480 ^@ http://purl.uniprot.org/uniprot/A8XVN3 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/6238:CBG_02162 ^@ http://purl.uniprot.org/uniprot/A8WS33 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/6238:CBG_17826 ^@ http://purl.uniprot.org/uniprot/A8XRV2 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6238:CBG_02335 ^@ http://purl.uniprot.org/uniprot/A8WUK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein srb family.|||Membrane http://togogenome.org/gene/6238:CBG_02775 ^@ http://purl.uniprot.org/uniprot/G2J6F0 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_09887 ^@ http://purl.uniprot.org/uniprot/A8X9W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTF2H2 family.|||Nucleus http://togogenome.org/gene/6238:CBG_01972 ^@ http://purl.uniprot.org/uniprot/A8WRQ3 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_20103 ^@ http://purl.uniprot.org/uniprot/A8XX36 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_24369 ^@ http://purl.uniprot.org/uniprot/G2J679 ^@ Similarity ^@ Belongs to the MAPRE family. http://togogenome.org/gene/6238:CBG_02059 ^@ http://purl.uniprot.org/uniprot/A8WRW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.|||Membrane http://togogenome.org/gene/6238:CBG_09538 ^@ http://purl.uniprot.org/uniprot/A8X8V4 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/6238:CBG_20085 ^@ http://purl.uniprot.org/uniprot/A8XX22 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_18269 ^@ http://purl.uniprot.org/uniprot/A8XSA7 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_09676 ^@ http://purl.uniprot.org/uniprot/Q61JR3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||Binds 2 manganese ions per subunit.|||Serine/threonine-protein phosphatase which antagonizes the function of air-2 in the regulation of chromosome cohesion. Dephosphorylates histone H3 at 'Ser-10'. Also involved in the activation of chloride channel clh-3 during cell swelling and meiotic maturation (By similarity). http://togogenome.org/gene/6238:CBG_16786 ^@ http://purl.uniprot.org/uniprot/Q17299 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Expressed primarily in touch receptor neurons.|||Mec-7 beta-tubulin is required for the production of 15-protofilament microtubules.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a role in mechanosensory transduction (touch sensitivity) (By similarity).|||cytoskeleton http://togogenome.org/gene/6238:CBG_10036 ^@ http://purl.uniprot.org/uniprot/Q61IX2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity).|||Nucleus http://togogenome.org/gene/6238:CBG_01385 ^@ http://purl.uniprot.org/uniprot/A8WQA4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_13492 ^@ http://purl.uniprot.org/uniprot/A8XI07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RRP8 family.|||Probable methyltransferase required to silence rDNA.|||nucleolus http://togogenome.org/gene/6238:CBG_05657 ^@ http://purl.uniprot.org/uniprot/A8X0D3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_08607 ^@ http://purl.uniprot.org/uniprot/A8X705 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/6238:CBG_16158 ^@ http://purl.uniprot.org/uniprot/A8XNZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.|||Belongs to the adaptor complexes large subunit family.|||coated pit http://togogenome.org/gene/6238:CBG_04002 ^@ http://purl.uniprot.org/uniprot/A8WVY8 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/6238:CBG_04130 ^@ http://purl.uniprot.org/uniprot/A8WVM4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis. Acts by regulating the activation of rab-5 by exchanging bound GDP for free GTP at clathrin coated pits (By similarity).|||Belongs to the GAPVD1 family.|||Interacts with GDP-bound rab-5. Interacts with alpha-adaptin (By similarity).|||Membrane|||clathrin-coated vesicle http://togogenome.org/gene/6238:CBG_17376 ^@ http://purl.uniprot.org/uniprot/A8XQX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||Structural component of the gap junctions.|||gap junction http://togogenome.org/gene/6238:CBG_20772 ^@ http://purl.uniprot.org/uniprot/A8XYK7 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA7 subunit family.|||Complex I is composed of 45 different subunits. http://togogenome.org/gene/6238:CBG_14280 ^@ http://purl.uniprot.org/uniprot/A8XJN7 ^@ Disruption Phenotype|||Function|||Subcellular Location Annotation ^@ Nucleus|||RNAi-mediated knockdown by injection into adults causes almost half of their progeny to terminally arrest at the larval L1 stage and the rest developed into fertile adults (PubMed:11044397). Simultaneous knockdown of forkhead gene pes-1 causes 8% embryonic lethality and 80% of progeny to arrest at larval L1 stage (PubMed:11044397).|||Transcription factor (By similarity). Plays a role in embryogenesis and later development, perhaps acting redundantly with forkhead protein pes-1 (PubMed:11044397). http://togogenome.org/gene/6238:CBG_20153 ^@ http://purl.uniprot.org/uniprot/A8XXB0 ^@ Similarity ^@ Belongs to the NSRP1 family. http://togogenome.org/gene/6238:CBG_05997 ^@ http://purl.uniprot.org/uniprot/A8X155 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_01499 ^@ http://purl.uniprot.org/uniprot/G2J6C6 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_19770 ^@ http://purl.uniprot.org/uniprot/A8XWC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_05037 ^@ http://purl.uniprot.org/uniprot/A8WZ13 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_23372 ^@ http://purl.uniprot.org/uniprot/A8Y428 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/6238:CBG_11315 ^@ http://purl.uniprot.org/uniprot/A8XDB0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_21627 ^@ http://purl.uniprot.org/uniprot/A8Y087 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Chromosome|||Nucleus http://togogenome.org/gene/6238:CBG_23185 ^@ http://purl.uniprot.org/uniprot/A8Y4H9 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_16479 ^@ http://purl.uniprot.org/uniprot/A8XP55 ^@ Similarity ^@ Belongs to the bystin family. http://togogenome.org/gene/6238:CBG_09573 ^@ http://purl.uniprot.org/uniprot/A8X8S4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 25 family. http://togogenome.org/gene/6238:CBG_17874 ^@ http://purl.uniprot.org/uniprot/A8XRZ8 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/6238:CBG_03939 ^@ http://purl.uniprot.org/uniprot/A8WVT3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/6238:CBG_19981 ^@ http://purl.uniprot.org/uniprot/A8XWV4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_03751 ^@ http://purl.uniprot.org/uniprot/A8WWM4 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/6238:CBG_09712 ^@ http://purl.uniprot.org/uniprot/Q61JN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SepSecS family.|||Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.|||Cytoplasm|||Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer. http://togogenome.org/gene/6238:CBG_02742 ^@ http://purl.uniprot.org/uniprot/A8WTL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/6238:CBG_02978 ^@ http://purl.uniprot.org/uniprot/A8WT26 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CybS family.|||Forms part of complex II containing four subunits: a flavoprotein (FP), an iron-sulfur protein (IP) and a cytochrome b composed of a large and a small subunit.|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_08759 ^@ http://purl.uniprot.org/uniprot/A8X7B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/6238:CBG_14645 ^@ http://purl.uniprot.org/uniprot/A8XKC9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_04280 ^@ http://purl.uniprot.org/uniprot/A8WX49 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/6238:CBG_07730 ^@ http://purl.uniprot.org/uniprot/A8X476 ^@ Similarity ^@ Belongs to the complex I 49 kDa subunit family. http://togogenome.org/gene/6238:CBG_09982 ^@ http://purl.uniprot.org/uniprot/A8XA35 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/6238:CBG_12782 ^@ http://purl.uniprot.org/uniprot/A8XGJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/6238:CBG_24575 ^@ http://purl.uniprot.org/uniprot/A8WL05 ^@ Similarity ^@ Belongs to the ZC3H14 family. http://togogenome.org/gene/6238:CBG_17980 ^@ http://purl.uniprot.org/uniprot/A8XSQ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Caudal homeobox family.|||Chromosome|||Interacts with tir-1 and let-756.|||Nucleus|||Transcriptional activator. Interacts with promoter regions for tbx-8.9, tbx-9, elt-1, hnd-1, scrt-1, and vab-7 genes. Binds the sequence ATTTATGAC. Binds to the enhancer region of the hlh-1 gene promoter during embryonic body wall muscle development. Activates the gene for mab-5 in embryo development. Necessary for vab-7 expression in C blastomeres in the posterior of embryos. Required for posterior V6 neuroectoblast cell fate specification during postembryonic neurogenesis (patterning) which generates the characteristic ray lineage during male tail development. Binds to ced-3 promoter and activated expression which is crucial for tail-spike cell death. Has a role in E cell specification in endoderm development and body wall muscle development (By similarity).|||kinetochore http://togogenome.org/gene/6238:CBG_17894 ^@ http://purl.uniprot.org/uniprot/A8XS17 ^@ Caution|||Cofactor|||Function|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Metalloprotease.|||Secreted http://togogenome.org/gene/6238:CBG_05777 ^@ http://purl.uniprot.org/uniprot/A8X1N3 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/6238:CBG_03824 ^@ http://purl.uniprot.org/uniprot/A8WWU4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/6238:CBG_14871 ^@ http://purl.uniprot.org/uniprot/A8XKV9 ^@ Similarity ^@ Belongs to the TCF25 family. http://togogenome.org/gene/6238:CBG_04560 ^@ http://purl.uniprot.org/uniprot/Q61W58 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 90 family.|||Homodimer. Interacts (via TPR repeat-binding and central region) with pph-5 (via phosphatase domain); the interaction promotes pph-5 phosphatase activity. Interacts (via central region) with co-chaperone cdc-37 (via N-terminus); the interaction inhibits daf-21 ATPase activity.|||Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another signal transduction component that regulates cGMP levels, plays a role in dauer formation and chemotaxis to non-volatile and volatile attractants detected by AWC sensory neurons. Participates in the control of cell cycle progression at the prophase/metaphase transition in oocyte development by ensuring the activity of wee-1.3 kinase, which negatively regulates cdk-1 through its phosphorylation. Regulates yap-1 nuclear export after heat shock treatment.|||The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.|||perinuclear region http://togogenome.org/gene/6238:CBG_07320 ^@ http://purl.uniprot.org/uniprot/A8X507 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/6238:CBG_12355 ^@ http://purl.uniprot.org/uniprot/A8XF84 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/6238:CBG_23912 ^@ http://purl.uniprot.org/uniprot/A8WJK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM21 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_03145 ^@ http://purl.uniprot.org/uniprot/A8WSP3 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/6238:CBG_08611 ^@ http://purl.uniprot.org/uniprot/A8X700 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_11716 ^@ http://purl.uniprot.org/uniprot/Q61FA3 ^@ Similarity ^@ Belongs to the acetyltransferase family. GNAT subfamily. http://togogenome.org/gene/6238:CBG_09341 ^@ http://purl.uniprot.org/uniprot/A8X9B8 ^@ Similarity ^@ Belongs to the Gfa family. http://togogenome.org/gene/6238:CBG_13013 ^@ http://purl.uniprot.org/uniprot/A8XGW3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. http://togogenome.org/gene/6238:CBG_00421 ^@ http://purl.uniprot.org/uniprot/A8WN19 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BBP/SF1 family.|||Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.|||Nucleus http://togogenome.org/gene/6238:CBG_00721 ^@ http://purl.uniprot.org/uniprot/A8WN79 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/6238:CBG_18132 ^@ http://purl.uniprot.org/uniprot/A8XT32 ^@ Similarity ^@ Belongs to the proteasome subunit S3 family. http://togogenome.org/gene/6238:CBG_23239 ^@ http://purl.uniprot.org/uniprot/A8Y4D9 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/6238:CBG_06776 ^@ http://purl.uniprot.org/uniprot/A8X319 ^@ Similarity ^@ Belongs to the acetyltransferase family. MAK3 subfamily. http://togogenome.org/gene/6238:CBG_14941 ^@ http://purl.uniprot.org/uniprot/A8XL21 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_07125 ^@ http://purl.uniprot.org/uniprot/A8X3N0 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/6238:CBG_11282 ^@ http://purl.uniprot.org/uniprot/A8XDD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||extracellular matrix http://togogenome.org/gene/6238:CBG_05668 ^@ http://purl.uniprot.org/uniprot/A8X0E3 ^@ Similarity ^@ Belongs to the GSKIP family. http://togogenome.org/gene/6238:CBG_21996 ^@ http://purl.uniprot.org/uniprot/A8Y1A9 ^@ Similarity ^@ Belongs to the glycosyltransferase 92 family. http://togogenome.org/gene/6238:CBG_02872 ^@ http://purl.uniprot.org/uniprot/A8WTB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane magnesium transporter (TC 1.A.67) family.|||Early endosome membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/6238:CBG_01370 ^@ http://purl.uniprot.org/uniprot/A8WQ91 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/6238:CBG_13973 ^@ http://purl.uniprot.org/uniprot/A8XIX2 ^@ Similarity ^@ Belongs to the HscB family. http://togogenome.org/gene/6238:CBG_23187 ^@ http://purl.uniprot.org/uniprot/A8Y4H7 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_04120 ^@ http://purl.uniprot.org/uniprot/A8WW92 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/6238:CBG_13576 ^@ http://purl.uniprot.org/uniprot/A8XI80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_19772 ^@ http://purl.uniprot.org/uniprot/A8XWC6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family. http://togogenome.org/gene/6238:CBG_08623 ^@ http://purl.uniprot.org/uniprot/A8X6Y8 ^@ Similarity ^@ Belongs to the glycosyltransferase 92 family. http://togogenome.org/gene/6238:CBG_05009 ^@ http://purl.uniprot.org/uniprot/A8WYZ1 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/6238:CBG_15942 ^@ http://purl.uniprot.org/uniprot/A8XNF4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/6238:CBG_10201 ^@ http://purl.uniprot.org/uniprot/A8XAV3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6238:CBG_19814 ^@ http://purl.uniprot.org/uniprot/A8XW88 ^@ Activity Regulation|||Developmental Stage|||Function|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. cAMP subfamily.|||Binding of cAMP to kin-2 regulatory subunits induces dissociation of the heterotetramer. The released catalytic subunits are active and able to phosphorylate their substrates.|||Essential for larval development. Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons. Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells. May play a role in the regulation of neuromuscular junctions.|||Expressed at low levels in the embryo. Expression increases after hatching and during larval stages and is followed by a decrease in adults (at protein level).|||Heterotetramer composed of two regulatory subunits and two catalytic subunits. http://togogenome.org/gene/6238:CBG_05789 ^@ http://purl.uniprot.org/uniprot/A8X1M4 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_15223 ^@ http://purl.uniprot.org/uniprot/A8XLM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/6238:CBG_01700 ^@ http://purl.uniprot.org/uniprot/A8WR20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RFT1 family.|||May be involved in N-linked oligosaccharide assembly.|||Membrane http://togogenome.org/gene/6238:CBG_13421 ^@ http://purl.uniprot.org/uniprot/A8XHT2 ^@ Similarity ^@ Belongs to the AP endonuclease 2 family. http://togogenome.org/gene/6238:CBG_22032 ^@ http://purl.uniprot.org/uniprot/A8Y1D6 ^@ Similarity ^@ Belongs to the MAP65/ASE1 family. http://togogenome.org/gene/6238:CBG_12820 ^@ http://purl.uniprot.org/uniprot/A8XFP5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6238:CBG_11579 ^@ http://purl.uniprot.org/uniprot/A8XDJ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/6238:CBG_03221 ^@ http://purl.uniprot.org/uniprot/A8WSI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB3 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_19207 ^@ http://purl.uniprot.org/uniprot/A8XV29 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/6238:CBG_21896 ^@ http://purl.uniprot.org/uniprot/A8Y124 ^@ Similarity ^@ Belongs to the glycosyltransferase 92 family. http://togogenome.org/gene/6238:CBG_09590 ^@ http://purl.uniprot.org/uniprot/A8X8Q7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus http://togogenome.org/gene/6238:CBG_04044 ^@ http://purl.uniprot.org/uniprot/A8WW27 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6238:CBG_21319 ^@ http://purl.uniprot.org/uniprot/A8XZU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/6238:CBG_18602 ^@ http://purl.uniprot.org/uniprot/A8XTP3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. http://togogenome.org/gene/6238:CBG_20021 ^@ http://purl.uniprot.org/uniprot/A8XWY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/6238:CBG_15774 ^@ http://purl.uniprot.org/uniprot/A8XMS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FRG1 family.|||Cajal body|||nucleolus http://togogenome.org/gene/6238:CBG_24280 ^@ http://purl.uniprot.org/uniprot/A8WKD3 ^@ Similarity ^@ Belongs to the NC2 beta/DR1 family. http://togogenome.org/gene/6238:CBG_16328 ^@ http://purl.uniprot.org/uniprot/Q613L4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). http://togogenome.org/gene/6238:CBG_22283 ^@ http://purl.uniprot.org/uniprot/A8Y1Z4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/6238:CBG_10037 ^@ http://purl.uniprot.org/uniprot/A8XA84 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/6238:CBG_03654 ^@ http://purl.uniprot.org/uniprot/A8WVI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF alpha subunit family.|||Nucleus|||TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. http://togogenome.org/gene/6238:CBG_13239 ^@ http://purl.uniprot.org/uniprot/A8XHD6 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_19620 ^@ http://purl.uniprot.org/uniprot/A8XW14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/6238:CBG_01222 ^@ http://purl.uniprot.org/uniprot/A8WPV8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_08614 ^@ http://purl.uniprot.org/uniprot/A8X6Z7 ^@ Similarity ^@ Belongs to the gluconokinase GntK/GntV family. http://togogenome.org/gene/6238:CBG_00634 ^@ http://purl.uniprot.org/uniprot/Q627K4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Cell membrane|||Cytoplasm|||GTP-binding protein that functions in embryogenesis, cytokinesis, germline development and microtubulule cytoskeleton dynamics.|||centrosome http://togogenome.org/gene/6238:CBG_01751 ^@ http://purl.uniprot.org/uniprot/A8WQX6 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srd family. http://togogenome.org/gene/6238:CBG_13442 ^@ http://purl.uniprot.org/uniprot/A8XHR4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COA3 family.|||Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.|||Membrane|||Required for assembly of cytochrome c oxidase (complex IV). http://togogenome.org/gene/6238:CBG_09001 ^@ http://purl.uniprot.org/uniprot/A8X815 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/6238:CBG_00606 ^@ http://purl.uniprot.org/uniprot/G2J6B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/6238:CBG_11796 ^@ http://purl.uniprot.org/uniprot/A8XE24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/6238:CBG_11840 ^@ http://purl.uniprot.org/uniprot/A8XE50 ^@ Similarity ^@ Belongs to the insulin family. http://togogenome.org/gene/6238:CBG_14675 ^@ http://purl.uniprot.org/uniprot/Q618G2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sterol desaturase family.|||Membrane|||Probable sterol desaturase. http://togogenome.org/gene/6238:CBG_12989 ^@ http://purl.uniprot.org/uniprot/A8XGU4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_17377 ^@ http://purl.uniprot.org/uniprot/A8XQX9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK1 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer. http://togogenome.org/gene/6238:CBG_04588 ^@ http://purl.uniprot.org/uniprot/A8WY01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Nucleus http://togogenome.org/gene/6238:CBG_12565 ^@ http://purl.uniprot.org/uniprot/A8XG21 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_21527 ^@ http://purl.uniprot.org/uniprot/A8Y0B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/6238:CBG_12081 ^@ http://purl.uniprot.org/uniprot/A8XEI3 ^@ Function|||Similarity ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. http://togogenome.org/gene/6238:CBG_21344 ^@ http://purl.uniprot.org/uniprot/A8XZW0 ^@ Similarity ^@ Belongs to the RRP7 family. http://togogenome.org/gene/6238:CBG_04190 ^@ http://purl.uniprot.org/uniprot/A8WWD7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6238:CBG_06539 ^@ http://purl.uniprot.org/uniprot/A8X2H1 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6238:CBG_04067 ^@ http://purl.uniprot.org/uniprot/Q6E3D5 ^@ Function ^@ Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs. http://togogenome.org/gene/6238:CBG_12806 ^@ http://purl.uniprot.org/uniprot/A8XFN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I NDUFA13 subunit family.|||Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_02202 ^@ http://purl.uniprot.org/uniprot/A8WSA7 ^@ Function|||Similarity ^@ Belongs to the SKP1 family.|||Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. http://togogenome.org/gene/6238:CBG_20871 ^@ http://purl.uniprot.org/uniprot/A8XYU4 ^@ Similarity ^@ Belongs to the BORA family. http://togogenome.org/gene/6238:CBG_05791 ^@ http://purl.uniprot.org/uniprot/A8X1M2 ^@ Function|||Similarity ^@ Belongs to the SKP1 family.|||Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. http://togogenome.org/gene/6238:CBG_15224 ^@ http://purl.uniprot.org/uniprot/A8XLM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/6238:CBG_09060 ^@ http://purl.uniprot.org/uniprot/A8X7W5 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/6238:CBG_23306 ^@ http://purl.uniprot.org/uniprot/Q60M48 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with sas-6 via its coiled coil domain.|||Required for centrosome duplication. Essential for daughter-centriole formation. Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis (By similarity).|||centriole http://togogenome.org/gene/6238:CBG_20944 ^@ http://purl.uniprot.org/uniprot/E3CU84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sre family.|||Membrane http://togogenome.org/gene/6238:CBG_04527 ^@ http://purl.uniprot.org/uniprot/A8WXN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/6238:CBG_04182 ^@ http://purl.uniprot.org/uniprot/A8WWD1 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_05272 ^@ http://purl.uniprot.org/uniprot/A8WZI3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_16494 ^@ http://purl.uniprot.org/uniprot/A8XPC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/6238:CBG_10009 ^@ http://purl.uniprot.org/uniprot/A8XA60 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_11304 ^@ http://purl.uniprot.org/uniprot/A8XDB9 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/6238:CBG_09724 ^@ http://purl.uniprot.org/uniprot/A8X8E9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6238:CBG_09461 ^@ http://purl.uniprot.org/uniprot/A8X920 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/6238:CBG_17350 ^@ http://purl.uniprot.org/uniprot/A8XQV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane http://togogenome.org/gene/6238:CBG_09586 ^@ http://purl.uniprot.org/uniprot/Q61JZ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin family. ARP2 subfamily.|||Component of the Arp2/3 complex.|||Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).|||cytoskeleton http://togogenome.org/gene/6238:CBG_17992 ^@ http://purl.uniprot.org/uniprot/A8XSR9 ^@ Similarity ^@ Belongs to the GIPC family. http://togogenome.org/gene/6238:CBG_14053 ^@ http://purl.uniprot.org/uniprot/A8XJ93 ^@ Disruption Phenotype|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Component of the large ribosomal subunit.|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.|||Cytoplasm|||Nucleus|||RNAi-mediated knockdown results in few viable embryos and as a result few live progeny and defective growth.|||There's a functional difference between the two L11-encoding proteins in C.briggsae. rpl-11.1 plays a role in the germline whereas rpl-11.2 has a somatic function. http://togogenome.org/gene/6238:CBG_12658 ^@ http://purl.uniprot.org/uniprot/A8XG99 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 37 family. http://togogenome.org/gene/6238:CBG_16933 ^@ http://purl.uniprot.org/uniprot/A8XQ33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/6238:CBG_17903 ^@ http://purl.uniprot.org/uniprot/A8XS25 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_05809 ^@ http://purl.uniprot.org/uniprot/A8X1K7 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/6238:CBG_14198 ^@ http://purl.uniprot.org/uniprot/A8XJH8 ^@ Similarity ^@ Belongs to the apyrase family. http://togogenome.org/gene/6238:CBG_16828 ^@ http://purl.uniprot.org/uniprot/G2J6X0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/6238:CBG_11934 ^@ http://purl.uniprot.org/uniprot/A8XEM6 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_01799 ^@ http://purl.uniprot.org/uniprot/A8WQT0 ^@ Similarity ^@ Belongs to the synaptojanin family.|||In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. http://togogenome.org/gene/6238:CBG_05551 ^@ http://purl.uniprot.org/uniprot/A8X050 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/6238:CBG_01406 ^@ http://purl.uniprot.org/uniprot/A8WQC4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_14784 ^@ http://purl.uniprot.org/uniprot/Q617Y0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GDA1/CD39 NTPase family.|||Golgi apparatus membrane|||Seems to be able to hydrolyze ADP, UDP and GDP. Supports mig-17 glycosylation and surface expression, which is required for proper migration of distal tip cells during gonad morphogenesis (By similarity). http://togogenome.org/gene/6238:CBG_23219 ^@ http://purl.uniprot.org/uniprot/A8Y4F5 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_11442 ^@ http://purl.uniprot.org/uniprot/A8XD04 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/6238:CBG_04116 ^@ http://purl.uniprot.org/uniprot/Q61X59 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAM41 family.|||Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane.|||Magnesium. Also active with cobalt or copper.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_01740 ^@ http://purl.uniprot.org/uniprot/Q623S8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial Rho GTPase family.|||Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.|||Mitochondrion outer membrane http://togogenome.org/gene/6238:CBG_00420 ^@ http://purl.uniprot.org/uniprot/A8WN18 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.|||Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. http://togogenome.org/gene/6238:CBG_16982 ^@ http://purl.uniprot.org/uniprot/A8XQ70 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_21929 ^@ http://purl.uniprot.org/uniprot/A8Y172 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_20759 ^@ http://purl.uniprot.org/uniprot/A8XYJ6 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit beta family. http://togogenome.org/gene/6238:CBG_01240 ^@ http://purl.uniprot.org/uniprot/A8WPX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_01314 ^@ http://purl.uniprot.org/uniprot/A8WQ43 ^@ Disruption Phenotype|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Component of the large ribosomal subunit.|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.|||Cytoplasm|||Nucleus|||RNAi-mediated knockdown results in sterility and a germ cell proliferation defect.|||There's a functional difference between the two L11-encoding proteins in C.briggsae. rpl-11.1 plays a role in the germline whereas rpl-11.2 has a somatic function. http://togogenome.org/gene/6238:CBG_02348 ^@ http://purl.uniprot.org/uniprot/A8WUJ1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/6238:CBG_04485 ^@ http://purl.uniprot.org/uniprot/A8WXS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acyltransferase which mediates the conversion of lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA or eicosapentaenoic acid (EPA) as the acyl donor. Prefers sn-2-LPI rather than sn-1-LPI as the acyl acceptor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (By similarity).|||Belongs to the membrane-bound acyltransferase family.|||Membrane http://togogenome.org/gene/6238:CBG_06059 ^@ http://purl.uniprot.org/uniprot/G2J6C3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_20644 ^@ http://purl.uniprot.org/uniprot/Q60T32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sra family.|||Membrane http://togogenome.org/gene/6238:CBG_01667 ^@ http://purl.uniprot.org/uniprot/A8WR45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the asunder family.|||Nucleus|||perinuclear region http://togogenome.org/gene/6238:CBG_09978 ^@ http://purl.uniprot.org/uniprot/A8XA30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS53 family.|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/6238:CBG_18055 ^@ http://purl.uniprot.org/uniprot/A8XSX7 ^@ Similarity ^@ Belongs to the insulin family. http://togogenome.org/gene/6238:CBG_06002 ^@ http://purl.uniprot.org/uniprot/A8X150 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/6238:CBG_10774 ^@ http://purl.uniprot.org/uniprot/A8XBR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TTC30/dfy-1/fleer family.|||Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. This protein is specifically required for the kinesin osm-3 to dock onto and move the IFT particles which contain these precursors.|||cilium http://togogenome.org/gene/6238:CBG_23443 ^@ http://purl.uniprot.org/uniprot/A8Y3W5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_00985 ^@ http://purl.uniprot.org/uniprot/A8WP62 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_10417 ^@ http://purl.uniprot.org/uniprot/A8XB58 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_12389 ^@ http://purl.uniprot.org/uniprot/A8XFB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/6238:CBG_02256 ^@ http://purl.uniprot.org/uniprot/A8WS58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates.|||Belongs to the helicase family. RAD3/XPD subfamily.|||Nucleus http://togogenome.org/gene/6238:CBG_09255 ^@ http://purl.uniprot.org/uniprot/A8X9I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA40 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/6238:CBG_13503 ^@ http://purl.uniprot.org/uniprot/A8XI17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms chloride channels.|||Membrane http://togogenome.org/gene/6238:CBG_16435 ^@ http://purl.uniprot.org/uniprot/A8XP28 ^@ Similarity|||Subunit ^@ Belongs to the RNase H2 subunit B family.|||The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C. http://togogenome.org/gene/6238:CBG_18327 ^@ http://purl.uniprot.org/uniprot/A8XSF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SYG1 (TC 2.A.94) family.|||Membrane http://togogenome.org/gene/6238:CBG_16374 ^@ http://purl.uniprot.org/uniprot/Q27459 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Oligomer composed of disulfide-linked homodimers.|||Rapidly hydrolyzes choline released into the synapse.|||Secreted|||Synapse http://togogenome.org/gene/6238:CBG_13719 ^@ http://purl.uniprot.org/uniprot/A8XIJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.|||Nucleus http://togogenome.org/gene/6238:CBG_12002 ^@ http://purl.uniprot.org/uniprot/A8XEB5 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/6238:CBG_19228 ^@ http://purl.uniprot.org/uniprot/A8XV48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 27 family.|||Nucleus http://togogenome.org/gene/6238:CBG_13922 ^@ http://purl.uniprot.org/uniprot/A8XJ11 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_09009 ^@ http://purl.uniprot.org/uniprot/A8X809 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_04929 ^@ http://purl.uniprot.org/uniprot/A8WYU0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_23735 ^@ http://purl.uniprot.org/uniprot/A8WJ63 ^@ Similarity ^@ Belongs to the nudE family. http://togogenome.org/gene/6238:CBG_24065 ^@ http://purl.uniprot.org/uniprot/G2J698 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_09260 ^@ http://purl.uniprot.org/uniprot/A8X9I2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP3 family.|||Golgi apparatus membrane|||Involved in the lipid remodeling steps of GPI-anchor maturation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/6238:CBG_06986 ^@ http://purl.uniprot.org/uniprot/A8X3Z5 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_08034 ^@ http://purl.uniprot.org/uniprot/A8X5M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/6238:CBG_00598 ^@ http://purl.uniprot.org/uniprot/Q627N3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||Binds 2 manganese ions per subunit.|||Cytoplasm|||Nucleus|||Serine/threonine-protein phosphatase essential for chromosomal dynamics during meiosis and mitosis. Antagonizes the function of air-2 in the regulation of chromosome cohesion. Dephosphorylates histone H3 at 'Ser-10'. Also involved in the activation of chloride channel clh-3 during cell swelling and meiotic maturation. Essential for embryogenesis (By similarity). http://togogenome.org/gene/6238:CBG_16221 ^@ http://purl.uniprot.org/uniprot/A8XNV3 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/6238:CBG_02865 ^@ http://purl.uniprot.org/uniprot/A8WTC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-binding oxidoreductase/transferase type 4 family.|||Peroxisome http://togogenome.org/gene/6238:CBG_17998 ^@ http://purl.uniprot.org/uniprot/A8XSS5 ^@ Similarity ^@ Belongs to the L-aspartate dehydrogenase family. http://togogenome.org/gene/6238:CBG_22193 ^@ http://purl.uniprot.org/uniprot/A8Y1R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. LDAH family.|||Lipid droplet http://togogenome.org/gene/6238:CBG_05884 ^@ http://purl.uniprot.org/uniprot/G2J6I6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_03801 ^@ http://purl.uniprot.org/uniprot/A8WWS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIc family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_00666 ^@ http://purl.uniprot.org/uniprot/A8WNC1 ^@ Similarity ^@ Belongs to the serine/threonine dehydratase family. http://togogenome.org/gene/6238:CBG_19251 ^@ http://purl.uniprot.org/uniprot/A8XV69 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/6238:CBG_05357 ^@ http://purl.uniprot.org/uniprot/A8WZN9 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_09634 ^@ http://purl.uniprot.org/uniprot/A8X8L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/6238:CBG_19349 ^@ http://purl.uniprot.org/uniprot/A8XVF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/6238:CBG_11776 ^@ http://purl.uniprot.org/uniprot/A8XE00 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.|||Binds 2 manganese ions per subunit.|||Cytoplasm|||Methylation at the C-terminal Leu-333 is critical for interactions with regulatory subunits.|||Protein phosphatase which plays an essential role in meiosis and in early embryonic mitosis. During spermatocyte meiosis and the first embryonic mitosis, regulates centrosome maturation, and thus spindle formation, by recruiting some of the components of the pericentriolar material (PCM). During oocyte meiosis I, regulates meiotic chromosome dynamics including synapsis-independent chromosome pairing, restriction of synapsis to homologous chromosomes, programmed DNA double-strand break initiation and crossover formation resulting in chiasma formation. During oocyte meiosis II and probably together with regulatory subunit ppfr-1, may regulate microtubule severing by dephosphorylating and activating mei-1, a component of the katanin microtubule severing complex.|||Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. The regulatory subunits are likely to be ppfr-1, ppfr-2, ppfr-4 and smk-1. Interacts with mei-1.|||centrosome http://togogenome.org/gene/6238:CBG_09400 ^@ http://purl.uniprot.org/uniprot/A8X966 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srd family. http://togogenome.org/gene/6238:CBG_01180 ^@ http://purl.uniprot.org/uniprot/A8WPS1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_08220 ^@ http://purl.uniprot.org/uniprot/A8X631 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAC14 family.|||Microsome membrane http://togogenome.org/gene/6238:CBG_19303 ^@ http://purl.uniprot.org/uniprot/A8XVB1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_17353 ^@ http://purl.uniprot.org/uniprot/A8XQW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tweety family.|||Cell membrane|||Membrane|||Probable chloride channel. http://togogenome.org/gene/6238:CBG_18950 ^@ http://purl.uniprot.org/uniprot/A8XUF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S33 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/6238:CBG_01500 ^@ http://purl.uniprot.org/uniprot/G2J6C3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_14299 ^@ http://purl.uniprot.org/uniprot/A8XJQ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_11572 ^@ http://purl.uniprot.org/uniprot/A8XDI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).|||Cytoplasm|||Nucleus http://togogenome.org/gene/6238:CBG_12442 ^@ http://purl.uniprot.org/uniprot/A8XFG0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_07332 ^@ http://purl.uniprot.org/uniprot/A8X4Z9 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/6238:CBG_01066 ^@ http://purl.uniprot.org/uniprot/A8WNZ3 ^@ Similarity ^@ Belongs to the CWC16 family. http://togogenome.org/gene/6238:CBG_15367 ^@ http://purl.uniprot.org/uniprot/A8XM18 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_10962 ^@ http://purl.uniprot.org/uniprot/A8XBY4 ^@ Similarity ^@ Belongs to the protein disulfide isomerase family. http://togogenome.org/gene/6238:CBG_07352 ^@ http://purl.uniprot.org/uniprot/A8X4Y6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_09214 ^@ http://purl.uniprot.org/uniprot/A8X8B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC45 family.|||Nucleus http://togogenome.org/gene/6238:CBG_19678 ^@ http://purl.uniprot.org/uniprot/A8XW63 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/6238:CBG_03555 ^@ http://purl.uniprot.org/uniprot/A8WVB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/6238:CBG_11280 ^@ http://purl.uniprot.org/uniprot/A8XDE0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_08337 ^@ http://purl.uniprot.org/uniprot/A8X6C1 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/6238:CBG_12664 ^@ http://purl.uniprot.org/uniprot/A8XGA3 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/6238:CBG_21312 ^@ http://purl.uniprot.org/uniprot/A8XZT4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_20986 ^@ http://purl.uniprot.org/uniprot/E3CU87 ^@ Caution|||Similarity ^@ Belongs to the nematode receptor-like protein srg family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_12325 ^@ http://purl.uniprot.org/uniprot/A8XFK0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/6238:CBG_00556 ^@ http://purl.uniprot.org/uniprot/A8WNL5 ^@ Similarity ^@ Belongs to the SEC2 family. http://togogenome.org/gene/6238:CBG_18722 ^@ http://purl.uniprot.org/uniprot/A8XTZ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_23368 ^@ http://purl.uniprot.org/uniprot/A8Y432 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aromatic-ring hydroxylase family. KMO subfamily.|||Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.|||Membrane|||Mitochondrion http://togogenome.org/gene/6238:CBG_05032 ^@ http://purl.uniprot.org/uniprot/A8WZ09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Porcupine subfamily.|||Key regulator of the Wnt signaling pathway that mediates lipid modification of Wnt proteins. Acts as a protein-serine O-palmitoleoyltransferase that catalyzes the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. Has a role in cell specification, specifically in blastomere signaling. Involved in cytosketetal polarity. Required for the orientation of mitotic spindle axis.|||Membrane http://togogenome.org/gene/6238:CBG_05461 ^@ http://purl.uniprot.org/uniprot/A8WZX6 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_13872 ^@ http://purl.uniprot.org/uniprot/A8XJ56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/6238:CBG_11406 ^@ http://purl.uniprot.org/uniprot/A8XD37 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_17045 ^@ http://purl.uniprot.org/uniprot/A8XQD0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/6238:CBG_18349 ^@ http://purl.uniprot.org/uniprot/A8XSI0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/6238:CBG_13220 ^@ http://purl.uniprot.org/uniprot/A8XHB7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/6238:CBG_05880 ^@ http://purl.uniprot.org/uniprot/A8X1F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/6238:CBG_09984 ^@ http://purl.uniprot.org/uniprot/A8XA37 ^@ Similarity ^@ Belongs to the lin-52 family. http://togogenome.org/gene/6238:CBG_08743 ^@ http://purl.uniprot.org/uniprot/A8X7A3 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/6238:CBG_19843 ^@ http://purl.uniprot.org/uniprot/A8XWK5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/6238:CBG_11250 ^@ http://purl.uniprot.org/uniprot/A8XDF5 ^@ Similarity ^@ Belongs to the OXR1 family. http://togogenome.org/gene/6238:CBG_21767 ^@ http://purl.uniprot.org/uniprot/A8Y0J1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/6238:CBG_11023 ^@ http://purl.uniprot.org/uniprot/A8XC21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/6238:CBG_02301 ^@ http://purl.uniprot.org/uniprot/A8WUM9 ^@ Similarity ^@ Belongs to the UPF0415 family. http://togogenome.org/gene/6238:CBG_22339 ^@ http://purl.uniprot.org/uniprot/A8Y267 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/6238:CBG_05062 ^@ http://purl.uniprot.org/uniprot/A8WZ31 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/6238:CBG_17990 ^@ http://purl.uniprot.org/uniprot/A8XSR7 ^@ Similarity ^@ Belongs to the maelstrom family. http://togogenome.org/gene/6238:CBG_10088 ^@ http://purl.uniprot.org/uniprot/A8XAD0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rheb family.|||Binds GTP and exhibits intrinsic GTPase activity.|||Cell membrane http://togogenome.org/gene/6238:CBG_01439 ^@ http://purl.uniprot.org/uniprot/A8WQF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_15726 ^@ http://purl.uniprot.org/uniprot/A8XMM5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/6238:CBG_23255 ^@ http://purl.uniprot.org/uniprot/A8Y4C6 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_01945 ^@ http://purl.uniprot.org/uniprot/A8WRM9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_09861 ^@ http://purl.uniprot.org/uniprot/A8X9U3 ^@ Similarity ^@ Belongs to the MAM33 family. http://togogenome.org/gene/6238:CBG_07059 ^@ http://purl.uniprot.org/uniprot/A8X3T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/6238:CBG_13974 ^@ http://purl.uniprot.org/uniprot/A8XIX1 ^@ Similarity ^@ Belongs to the tRNA-intron endonuclease family. http://togogenome.org/gene/6238:CBG_10645 ^@ http://purl.uniprot.org/uniprot/A8XBI4 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/6238:CBG_15716 ^@ http://purl.uniprot.org/uniprot/A8XML6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FAD-binding oxidoreductase/transferase type 4 family.|||Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.|||Homodimer.|||Peroxisome http://togogenome.org/gene/6238:CBG_08820 ^@ http://purl.uniprot.org/uniprot/A8X7G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/6238:CBG_07339 ^@ http://purl.uniprot.org/uniprot/A8X4Z4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Membrane http://togogenome.org/gene/6238:CBG_12849 ^@ http://purl.uniprot.org/uniprot/A8XFR1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/6238:CBG_01975 ^@ http://purl.uniprot.org/uniprot/A8WRQ4 ^@ Cofactor|||Similarity ^@ Belongs to the glutamate synthase family.|||Binds 1 [3Fe-4S] cluster. http://togogenome.org/gene/6238:CBG_22870 ^@ http://purl.uniprot.org/uniprot/A8Y393 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_11916 ^@ http://purl.uniprot.org/uniprot/A8XEL0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/6238:CBG_05858 ^@ http://purl.uniprot.org/uniprot/A8X1H0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.|||Membrane|||Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. http://togogenome.org/gene/6238:CBG_15266 ^@ http://purl.uniprot.org/uniprot/A8XLI8 ^@ Similarity ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. http://togogenome.org/gene/6238:CBG_18401 ^@ http://purl.uniprot.org/uniprot/A8XT89 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 3 family.|||Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. http://togogenome.org/gene/6238:CBG_09101 ^@ http://purl.uniprot.org/uniprot/A8X7S9 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/6238:CBG_06954 ^@ http://purl.uniprot.org/uniprot/A8X422 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_08212 ^@ http://purl.uniprot.org/uniprot/A8X623 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme c group covalently per subunit.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_12227 ^@ http://purl.uniprot.org/uniprot/A8XEY1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sterol desaturase family. SCS7 subfamily.|||Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.|||Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_18105 ^@ http://purl.uniprot.org/uniprot/A8XT16 ^@ Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) (By similarity). http://togogenome.org/gene/6238:CBG_01720 ^@ http://purl.uniprot.org/uniprot/A8WR03 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/6238:CBG_14977 ^@ http://purl.uniprot.org/uniprot/A8XL49 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_23985 ^@ http://purl.uniprot.org/uniprot/A8WJQ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_05040 ^@ http://purl.uniprot.org/uniprot/A8WZ16 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_11395 ^@ http://purl.uniprot.org/uniprot/A8XD44 ^@ Similarity ^@ Belongs to the GAMAD family. http://togogenome.org/gene/6238:CBG_21822 ^@ http://purl.uniprot.org/uniprot/A8Y0W5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_18665 ^@ http://purl.uniprot.org/uniprot/A8XTU8 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/6238:CBG_24035 ^@ http://purl.uniprot.org/uniprot/A8WJU7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_18196 ^@ http://purl.uniprot.org/uniprot/A8XT88 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FBXO45/Fsn family.|||Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf-2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM and ALM neurons.|||Component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex composed of cul-1, fsn-1, rpm-1 and skr-1. Interacts (via SPRY domain) with scd-2 (via cytoplasmic domain). Interacts (via SPRY domain) with convertase egl-3 (via C-terminus).|||Synapse http://togogenome.org/gene/6238:CBG_10094 ^@ http://purl.uniprot.org/uniprot/A8XAD6 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/6238:CBG_12006 ^@ http://purl.uniprot.org/uniprot/A8XEB8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/6238:CBG_18827 ^@ http://purl.uniprot.org/uniprot/A8XU71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA2 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_13820 ^@ http://purl.uniprot.org/uniprot/A8XIS2 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/6238:CBG_05141 ^@ http://purl.uniprot.org/uniprot/A8WZ66 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/6238:CBG_07280 ^@ http://purl.uniprot.org/uniprot/A8X530 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/6238:CBG_24496 ^@ http://purl.uniprot.org/uniprot/A8WKU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||cytoskeleton http://togogenome.org/gene/6238:CBG_11926 ^@ http://purl.uniprot.org/uniprot/A8XEL9 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/6238:CBG_20860 ^@ http://purl.uniprot.org/uniprot/A8XYT3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_05290 ^@ http://purl.uniprot.org/uniprot/A8WZJ6 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srd family. http://togogenome.org/gene/6238:CBG_05762 ^@ http://purl.uniprot.org/uniprot/A8X1P4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/6238:CBG_04512 ^@ http://purl.uniprot.org/uniprot/A8WXQ2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_00438 ^@ http://purl.uniprot.org/uniprot/A8WN34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/6238:CBG_17403 ^@ http://purl.uniprot.org/uniprot/A8XQZ6 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_07217 ^@ http://purl.uniprot.org/uniprot/A8X3G6 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_01648 ^@ http://purl.uniprot.org/uniprot/A8WR61 ^@ Similarity ^@ Belongs to the cytochrome c oxidase subunit 6c family. http://togogenome.org/gene/6238:CBG_19904 ^@ http://purl.uniprot.org/uniprot/A8XWP9 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srd family. http://togogenome.org/gene/6238:CBG_14147 ^@ http://purl.uniprot.org/uniprot/A8XJE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 65 family.|||Belongs to the syntaxin family.|||Membrane http://togogenome.org/gene/6238:CBG_16677 ^@ http://purl.uniprot.org/uniprot/A8XPA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. http://togogenome.org/gene/6238:CBG_07446 ^@ http://purl.uniprot.org/uniprot/A8X4R2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 37 family. http://togogenome.org/gene/6238:CBG_07596 ^@ http://purl.uniprot.org/uniprot/A8X4H2 ^@ Similarity ^@ Belongs to the epsin family. http://togogenome.org/gene/6238:CBG_13059 ^@ http://purl.uniprot.org/uniprot/A8XGZ6 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srd family. http://togogenome.org/gene/6238:CBG_01011 ^@ http://purl.uniprot.org/uniprot/A8WP42 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/6238:CBG_06978 ^@ http://purl.uniprot.org/uniprot/A8X402 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||extracellular matrix http://togogenome.org/gene/6238:CBG_15526 ^@ http://purl.uniprot.org/uniprot/A8XM58 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/6238:CBG_13529 ^@ http://purl.uniprot.org/uniprot/A8XI39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARMET family.|||Secreted http://togogenome.org/gene/6238:CBG_18047 ^@ http://purl.uniprot.org/uniprot/A8XSX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/6238:CBG_18935 ^@ http://purl.uniprot.org/uniprot/A8XUD9 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/6238:CBG_09472 ^@ http://purl.uniprot.org/uniprot/A8X914 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase K family.|||Membrane http://togogenome.org/gene/6238:CBG_06709 ^@ http://purl.uniprot.org/uniprot/A8X2X2 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srd family. http://togogenome.org/gene/6238:CBG_03541 ^@ http://purl.uniprot.org/uniprot/A8WVA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat HIR1 family.|||Nucleus http://togogenome.org/gene/6238:CBG_22137 ^@ http://purl.uniprot.org/uniprot/Q60PR7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the semaphorin family.|||Interacts with plx-2.|||Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting and allows the formation of distinct sensory rays. Seems to control cell-cell contact formation through 2 parallel pathways, one involving efn-4 and one involving plx-2 and unc-129. Involved in axon guidance. Probably by binding receptor plx-2, regulates fln-1-mediated remodeling of the actin cytoskeleton and thus axon guidance and/or fasciculation of DD/VD neurons.|||Secreted http://togogenome.org/gene/6238:CBG_18133 ^@ http://purl.uniprot.org/uniprot/A8XT33 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/6238:CBG_22021 ^@ http://purl.uniprot.org/uniprot/A8Y1C7 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.|||Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. http://togogenome.org/gene/6238:CBG_12269 ^@ http://purl.uniprot.org/uniprot/A8XF50 ^@ Similarity ^@ Belongs to the TIP41 family. http://togogenome.org/gene/6238:CBG_16977 ^@ http://purl.uniprot.org/uniprot/A8XQ65 ^@ Similarity ^@ Belongs to the PNP/MTAP phosphorylase family. http://togogenome.org/gene/6238:CBG_08510 ^@ http://purl.uniprot.org/uniprot/A8X6Q9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/6238:CBG_15417 ^@ http://purl.uniprot.org/uniprot/A8XMB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM237 family.|||Component of the transition zone in primary cilia. Required for ciliogenesis.|||Membrane|||cilium http://togogenome.org/gene/6238:CBG_20970 ^@ http://purl.uniprot.org/uniprot/E3CU85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sre family.|||Membrane http://togogenome.org/gene/6238:CBG_08037 ^@ http://purl.uniprot.org/uniprot/A8X5M7 ^@ Similarity ^@ Belongs to the GPI family. http://togogenome.org/gene/6238:CBG_04022 ^@ http://purl.uniprot.org/uniprot/A8WW05 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_10828 ^@ http://purl.uniprot.org/uniprot/A8XBW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP31 family.|||Nucleus http://togogenome.org/gene/6238:CBG_03181 ^@ http://purl.uniprot.org/uniprot/A8WSL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RER1 family.|||Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.|||Membrane http://togogenome.org/gene/6238:CBG_05526 ^@ http://purl.uniprot.org/uniprot/A8X031 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_00321 ^@ http://purl.uniprot.org/uniprot/A8WMP9 ^@ Similarity ^@ Belongs to the RdRP family. http://togogenome.org/gene/6238:CBG_11176 ^@ http://purl.uniprot.org/uniprot/A8XCM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/6238:CBG_22471 ^@ http://purl.uniprot.org/uniprot/A8Y2D2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_17398 ^@ http://purl.uniprot.org/uniprot/A8XQZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM129 family.|||Membrane http://togogenome.org/gene/6238:CBG_10120 ^@ http://purl.uniprot.org/uniprot/A8XAF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_18638 ^@ http://purl.uniprot.org/uniprot/A8XTS4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_09040 ^@ http://purl.uniprot.org/uniprot/A8X7Y5 ^@ Function|||Similarity ^@ Belongs to the SKP1 family.|||Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. http://togogenome.org/gene/6238:CBG_09495 ^@ http://purl.uniprot.org/uniprot/Q61K76 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit K family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/6238:CBG_06591 ^@ http://purl.uniprot.org/uniprot/A8X2L4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_17872 ^@ http://purl.uniprot.org/uniprot/A8XRZ6 ^@ Similarity ^@ Belongs to the glycosyltransferase 92 family. http://togogenome.org/gene/6238:CBG_21895 ^@ http://purl.uniprot.org/uniprot/A8Y125 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/6238:CBG_05962 ^@ http://purl.uniprot.org/uniprot/A8X182 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/6238:CBG_02254 ^@ http://purl.uniprot.org/uniprot/G2J682 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/6238:CBG_05843 ^@ http://purl.uniprot.org/uniprot/G2J6I6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_22274 ^@ http://purl.uniprot.org/uniprot/A8Y1Y5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS10 family. http://togogenome.org/gene/6238:CBG_02876 ^@ http://purl.uniprot.org/uniprot/A8WTB3 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_22157 ^@ http://purl.uniprot.org/uniprot/Q60PP8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Positively regulates a late step in synaptic vesicle exocytosis.|||cytosol http://togogenome.org/gene/6238:CBG_02554 ^@ http://purl.uniprot.org/uniprot/A8WU20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/6238:CBG_06811 ^@ http://purl.uniprot.org/uniprot/A8X347 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty-acid and retinol-binding protein (FARBP) family.|||Secreted http://togogenome.org/gene/6238:CBG_20959 ^@ http://purl.uniprot.org/uniprot/A8XZ18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sre family.|||Membrane http://togogenome.org/gene/6238:CBG_13580 ^@ http://purl.uniprot.org/uniprot/A8XI84 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/6238:CBG_19286 ^@ http://purl.uniprot.org/uniprot/A8XV95 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the villin/gelsolin family.|||Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development.|||Monomer. Binds to actin monomers and filaments.|||cytoskeleton http://togogenome.org/gene/6238:CBG_10873 ^@ http://purl.uniprot.org/uniprot/A8XC66 ^@ Caution|||Cofactor|||Function ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Metalloprotease. http://togogenome.org/gene/6238:CBG_11960 ^@ http://purl.uniprot.org/uniprot/A8XEP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB7 subunit family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/6238:CBG_16863 ^@ http://purl.uniprot.org/uniprot/A8XPY9 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_02488 ^@ http://purl.uniprot.org/uniprot/A8WU73 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/6238:CBG_19330 ^@ http://purl.uniprot.org/uniprot/A8XVD5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane|||May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.|||Membrane|||Microsome membrane http://togogenome.org/gene/6238:CBG_12758 ^@ http://purl.uniprot.org/uniprot/A8XGI3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6238:CBG_06102 ^@ http://purl.uniprot.org/uniprot/A8X0W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the taffazin family.|||Mitochondrion inner membrane|||Mitochondrion outer membrane http://togogenome.org/gene/6238:CBG_08326 ^@ http://purl.uniprot.org/uniprot/A8X6B1 ^@ Similarity ^@ Belongs to the dus family. Dus3 subfamily. http://togogenome.org/gene/6238:CBG_09612 ^@ http://purl.uniprot.org/uniprot/P90728 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_09147 ^@ http://purl.uniprot.org/uniprot/A8X867 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/6238:CBG_08000 ^@ http://purl.uniprot.org/uniprot/A8X5J7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipid scramblase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/6238:CBG_22646 ^@ http://purl.uniprot.org/uniprot/A8Y2R9 ^@ Similarity ^@ Belongs to the CWC15 family. http://togogenome.org/gene/6238:CBG_15946 ^@ http://purl.uniprot.org/uniprot/A8XNF0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acyl-CoA dehydrogenase family.|||Homotetramer.|||Mitochondrion matrix|||This enzyme is specific for acyl chain lengths of 4 to 16. http://togogenome.org/gene/6238:CBG_15767 ^@ http://purl.uniprot.org/uniprot/Q615A2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SPCS2 family.|||Component of the signal peptidase complex (SPC) composed of a catalytic subunit sec-11 and three accessory subunits spcs-1, spcs-2 and spcs-3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids.|||Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity).|||Endoplasmic reticulum membrane http://togogenome.org/gene/6238:CBG_22041 ^@ http://purl.uniprot.org/uniprot/A8Y1E3 ^@ Similarity ^@ Belongs to the eIF-2-alpha family. http://togogenome.org/gene/6238:CBG_16480 ^@ http://purl.uniprot.org/uniprot/A8XP56 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/6238:CBG_21169 ^@ http://purl.uniprot.org/uniprot/A8XZC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Belongs to the pex2/pex10/pex12 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/6238:CBG_18644 ^@ http://purl.uniprot.org/uniprot/A8XTS9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_11701 ^@ http://purl.uniprot.org/uniprot/A8XDX6 ^@ Similarity ^@ Belongs to the chaperonin (HSP60) family. http://togogenome.org/gene/6238:CBG_00482 ^@ http://purl.uniprot.org/uniprot/A8WMR8 ^@ Function|||Similarity ^@ Belongs to the SKP1 family.|||Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. http://togogenome.org/gene/6238:CBG_24151 ^@ http://purl.uniprot.org/uniprot/A8WK32 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_17371 ^@ http://purl.uniprot.org/uniprot/A8XQX4 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/6238:CBG_07618 ^@ http://purl.uniprot.org/uniprot/A8X4F7 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_06916 ^@ http://purl.uniprot.org/uniprot/A8X3C9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/6238:CBG_13115 ^@ http://purl.uniprot.org/uniprot/A8XH42 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/6238:CBG_06307 ^@ http://purl.uniprot.org/uniprot/A8X1X4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_04050 ^@ http://purl.uniprot.org/uniprot/A8WW33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/6238:CBG_11418 ^@ http://purl.uniprot.org/uniprot/A8XD26 ^@ Similarity ^@ Belongs to the glycosyltransferase 28 family. http://togogenome.org/gene/6238:CBG_02964 ^@ http://purl.uniprot.org/uniprot/A8WT36 ^@ Similarity ^@ Belongs to the APC1 family. http://togogenome.org/gene/6238:CBG_03598 ^@ http://purl.uniprot.org/uniprot/A8WVF2 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/6238:CBG_20737 ^@ http://purl.uniprot.org/uniprot/A8XYH6 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/6238:CBG_03454 ^@ http://purl.uniprot.org/uniprot/A8WV38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAF1 family.|||Nucleus http://togogenome.org/gene/6238:CBG_15749 ^@ http://purl.uniprot.org/uniprot/A8XMP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/6238:CBG_06202 ^@ http://purl.uniprot.org/uniprot/A8X0N8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_16082 ^@ http://purl.uniprot.org/uniprot/A8XN52 ^@ Caution|||Similarity ^@ Belongs to the globin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_20268 ^@ http://purl.uniprot.org/uniprot/A8XXD4 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/6238:CBG_00427 ^@ http://purl.uniprot.org/uniprot/A8WN24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/6238:CBG_14383 ^@ http://purl.uniprot.org/uniprot/A8XJV8 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/6238:CBG_01480 ^@ http://purl.uniprot.org/uniprot/A8WQK9 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6238:CBG_22468 ^@ http://purl.uniprot.org/uniprot/A8Y2C9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF1 family.|||Mitochondrion inner membrane|||Probably involved in the biogenesis of the COX complex. http://togogenome.org/gene/6238:CBG_22278 ^@ http://purl.uniprot.org/uniprot/A8Y1Y9 ^@ Similarity ^@ Belongs to the cuticular collagen family. http://togogenome.org/gene/6238:CBG_14554 ^@ http://purl.uniprot.org/uniprot/A8XK65 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_16660 ^@ http://purl.uniprot.org/uniprot/A8XP91 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Has a role in the homologous recombination repair (HRR) of genomic DNA during meiosis. Required for rad-51 recruitment onto ssDNA gaps generated at stalled replication fork barriers (By similarity).|||Interacts with brc-2 and rad-51.|||Nucleus http://togogenome.org/gene/6238:CBG_05039 ^@ http://purl.uniprot.org/uniprot/A8WZ15 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_02161 ^@ http://purl.uniprot.org/uniprot/A8WS32 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/6238:CBG_18183 ^@ http://purl.uniprot.org/uniprot/A8XT75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Membrane http://togogenome.org/gene/6238:CBG_06228 ^@ http://purl.uniprot.org/uniprot/Q61SD1 ^@ Function|||Similarity ^@ Belongs to the MON2 family.|||May be required for traffic between late Golgi and early endosomes. http://togogenome.org/gene/6238:CBG_05778 ^@ http://purl.uniprot.org/uniprot/A8X1N2 ^@ Similarity ^@ Belongs to the BLOC1S5 family. http://togogenome.org/gene/6238:CBG_15715 ^@ http://purl.uniprot.org/uniprot/A8XML5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/6238:CBG_24615 ^@ http://purl.uniprot.org/uniprot/A8WL28 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with hcp-3 and hcp-4 to form a complex. Interacts with hcp-4, him-10, kbp-3, kbp-4, kbp-5, knl-3, and ndc-80. Interacts with kbp-1, kbp-2 and mis-12; which make up the MIS12 complex.|||Proposed to be part of the KMN network incorporating the MIS12 complex and NDC80 complex that is required for establishing the kinetochore-microtubule interface that aids in chromosome segregation during meiotic and mitotic cell division. Appears to function downstream of hcp-3 (CENP-A) and hcp-4 (CENP-C) in the kinetochore assembly hierarchy. Has a role in the correct localization of spdl-1 and the RZZ complex that is composed of rod-1, czw-1 and zwl-1. Required for the recruitment of spindle-assembly checkpoint components bub-1 and mdf-1/2 to unattached kinetochores (By similarity).|||The N-terminus contains a number of repeats which contribute additively to bub-1 recruitment to unattached kinetochores. The repeats are not required for localization to kinetochores (By similarity).|||cell cortex|||kinetochore http://togogenome.org/gene/6238:CBG_21205 ^@ http://purl.uniprot.org/uniprot/A8XZL7 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/6238:CBG_00744 ^@ http://purl.uniprot.org/uniprot/A8WN59 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/6238:CBG_11640 ^@ http://purl.uniprot.org/uniprot/A8XDP6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/6238:CBG_09642 ^@ http://purl.uniprot.org/uniprot/A8X8K8 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I family. http://togogenome.org/gene/6238:CBG_16937 ^@ http://purl.uniprot.org/uniprot/A8XQ37 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_00732 ^@ http://purl.uniprot.org/uniprot/A8WN70 ^@ Similarity ^@ Belongs to the AAA ATPase family. PCH2 subfamily. http://togogenome.org/gene/6238:CBG_05672 ^@ http://purl.uniprot.org/uniprot/A8X0E7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_03991 ^@ http://purl.uniprot.org/uniprot/A8WVX8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit I family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/6238:CBG_06882 ^@ http://purl.uniprot.org/uniprot/A8X3A0 ^@ Similarity ^@ Belongs to the thiamine pyrophosphokinase family. http://togogenome.org/gene/6238:CBG_09137 ^@ http://purl.uniprot.org/uniprot/A8X860 ^@ Similarity ^@ Belongs to the CBF/MAK21 family. http://togogenome.org/gene/6238:CBG_07376 ^@ http://purl.uniprot.org/uniprot/A8X4W8 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/6238:CBG_17938 ^@ http://purl.uniprot.org/uniprot/A8XRY3 ^@ Caution|||Similarity ^@ Belongs to the nematode receptor-like protein srg family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_15112 ^@ http://purl.uniprot.org/uniprot/A8XLG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_12712 ^@ http://purl.uniprot.org/uniprot/A8XGE3 ^@ Cofactor|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit. http://togogenome.org/gene/6238:CBG_09063 ^@ http://purl.uniprot.org/uniprot/A8X7W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Nucleus http://togogenome.org/gene/6238:CBG_01959 ^@ http://purl.uniprot.org/uniprot/A8WRP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/6238:CBG_19036 ^@ http://purl.uniprot.org/uniprot/A8XUM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_07642 ^@ http://purl.uniprot.org/uniprot/A8X4D8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_17334 ^@ http://purl.uniprot.org/uniprot/A8XQU6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_20982 ^@ http://purl.uniprot.org/uniprot/E3CU86 ^@ Caution|||Similarity ^@ Belongs to the nematode receptor-like protein srg family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_08018 ^@ http://purl.uniprot.org/uniprot/A8X5L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 8 family.|||Nucleus http://togogenome.org/gene/6238:CBG_21264 ^@ http://purl.uniprot.org/uniprot/A8XZQ4 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_02260 ^@ http://purl.uniprot.org/uniprot/A8WS55 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL10 family.|||Ribosomal protein P0 is the functional equivalent of E.coli protein L10. http://togogenome.org/gene/6238:CBG_14491 ^@ http://purl.uniprot.org/uniprot/A8XK18 ^@ Similarity ^@ Belongs to the arthropod CHH/MIH/GIH/VIH hormone family. http://togogenome.org/gene/6238:CBG_04612 ^@ http://purl.uniprot.org/uniprot/A8WY22 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/6238:CBG_01247 ^@ http://purl.uniprot.org/uniprot/A8WPY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_15197 ^@ http://purl.uniprot.org/uniprot/A8XLP9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/6238:CBG_18256 ^@ http://purl.uniprot.org/uniprot/A8XS95 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/6238:CBG_24607 ^@ http://purl.uniprot.org/uniprot/P41955 ^@ Cofactor|||Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b560 family.|||Component of complex II composed of four subunits: a flavoprotein (FP), iron-sulfur protein (IP), and a cytochrome b560 composed of two transmembrane proteins.|||Is expressed at a constant level throughout development.|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Mediates resistance to enteropathogenic E.coli infection (By similarity).|||Mitochondrion inner membrane|||The heme is bound between the two transmembrane subunits. http://togogenome.org/gene/6238:CBG_22132 ^@ http://purl.uniprot.org/uniprot/A8Y1L5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_00960 ^@ http://purl.uniprot.org/uniprot/A8WP84 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/6238:CBG_03124 ^@ http://purl.uniprot.org/uniprot/A8WSR0 ^@ Similarity ^@ Belongs to the histone deacetylase family. HD type 2 subfamily. http://togogenome.org/gene/6238:CBG_12350 ^@ http://purl.uniprot.org/uniprot/A8XFM5 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/6238:CBG_15663 ^@ http://purl.uniprot.org/uniprot/A8XMH5 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/6238:CBG_05943 ^@ http://purl.uniprot.org/uniprot/Q61T16 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.|||Mitochondrion http://togogenome.org/gene/6238:CBG_22212 ^@ http://purl.uniprot.org/uniprot/A8Y1T1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL27 family. http://togogenome.org/gene/6238:CBG_18577 ^@ http://purl.uniprot.org/uniprot/A8XTM3 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/6238:CBG_08188 ^@ http://purl.uniprot.org/uniprot/A8X610 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/6238:CBG_06194 ^@ http://purl.uniprot.org/uniprot/A8X0P6 ^@ Similarity ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. http://togogenome.org/gene/6238:CBG_13546 ^@ http://purl.uniprot.org/uniprot/A8XI56 ^@ Similarity ^@ In the C-terminal section; belongs to the saccharopine dehydrogenase family.|||In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/6238:CBG_23444 ^@ http://purl.uniprot.org/uniprot/G2J6I6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_09483 ^@ http://purl.uniprot.org/uniprot/A8X904 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/6238:CBG_02845 ^@ http://purl.uniprot.org/uniprot/A8WTE1 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/6238:CBG_02966 ^@ http://purl.uniprot.org/uniprot/A8WT35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NASP family.|||Nucleus http://togogenome.org/gene/6238:CBG_08166 ^@ http://purl.uniprot.org/uniprot/A8X5Z0 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_03286 ^@ http://purl.uniprot.org/uniprot/A8WSD6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms chloride channels.|||Membrane http://togogenome.org/gene/6238:CBG_12247 ^@ http://purl.uniprot.org/uniprot/A8XF32 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_18231 ^@ http://purl.uniprot.org/uniprot/Q60YI3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs).|||Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).|||nucleolus http://togogenome.org/gene/6238:CBG_09945 ^@ http://purl.uniprot.org/uniprot/A8XA06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_03981 ^@ http://purl.uniprot.org/uniprot/P0C664 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZWILCH family.|||Component of the RZZ complex composed of rod-1, czw-1 and zwl-1. Interacts with the spindly-like protein spdl-1. Interacts with NDC80 complex component ndc-80.|||Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for chromosome segregation, the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores and spindle pole separation. Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex. The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores. To prevent irregular chromosome segregation, the complex also inhibits the attachment of the kinetochore-associated NDC80 complex to microtubules. The recruitment of spdl-1 to kinetochores relieves this inhibition. Required for embryonic development.|||cell cortex|||kinetochore|||spindle http://togogenome.org/gene/6238:CBG_00829 ^@ http://purl.uniprot.org/uniprot/A8WNX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_22044 ^@ http://purl.uniprot.org/uniprot/A8Y1E6 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/6238:CBG_02961 ^@ http://purl.uniprot.org/uniprot/A8WT40 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.|||Binds 1 Mg(2+) ion per monomer.|||Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Nucleus http://togogenome.org/gene/6238:CBG_06836 ^@ http://purl.uniprot.org/uniprot/A8X367 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/6238:CBG_23452 ^@ http://purl.uniprot.org/uniprot/A8Y3V7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase e subunit family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_09596 ^@ http://purl.uniprot.org/uniprot/A8X8Q1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_21781 ^@ http://purl.uniprot.org/uniprot/A8Y0I0 ^@ Similarity ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family. http://togogenome.org/gene/6238:CBG_12888 ^@ http://purl.uniprot.org/uniprot/A8XFU0 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/6238:CBG_13828 ^@ http://purl.uniprot.org/uniprot/A8XIS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/6238:CBG_16647 ^@ http://purl.uniprot.org/uniprot/A8XP79 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/6238:CBG_01578 ^@ http://purl.uniprot.org/uniprot/A8WRB9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/6238:CBG_11756 ^@ http://purl.uniprot.org/uniprot/A8XDT0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.|||cytosol http://togogenome.org/gene/6238:CBG_02381 ^@ http://purl.uniprot.org/uniprot/A8WUG4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm|||Interaction with par-3 required for the peripheral localization of par-6 and to form a par-3/par-6/pkc-3 complex, which is activated when cdc-42 interacts with par-6. Binds avidly to the phosphotyrosine interaction domain (PID) of a novel pkc-3 adapter protein num-1, which enables tethering and targeting of pkc-3 to the cell periphery (By similarity).|||Required for the normal progression of embryogenesis and viability of the organism. Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3. Required for epithelial cell polarity in the distal spermatheca. Phosphorylates serine residues of num-1. Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury.|||cytoskeleton http://togogenome.org/gene/6238:CBG_06112 ^@ http://purl.uniprot.org/uniprot/A8X0V6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 25 family. http://togogenome.org/gene/6238:CBG_04491 ^@ http://purl.uniprot.org/uniprot/A8WXR8 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/6238:CBG_15783 ^@ http://purl.uniprot.org/uniprot/A8XMS9 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_09354 ^@ http://purl.uniprot.org/uniprot/A8X9A5 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_13937 ^@ http://purl.uniprot.org/uniprot/Q61A42 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 20 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/6238:CBG_19216 ^@ http://purl.uniprot.org/uniprot/A8XV36 ^@ Function|||Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.|||Nematode cuticles are composed largely of collagen-like proteins (Probable). The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (Probable). http://togogenome.org/gene/6238:CBG_23734 ^@ http://purl.uniprot.org/uniprot/A8WJ62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes large subunit family.|||Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.|||clathrin-coated vesicle membrane http://togogenome.org/gene/6238:CBG_23913 ^@ http://purl.uniprot.org/uniprot/A8WJK4 ^@ Similarity ^@ Belongs to the SRR1 family. http://togogenome.org/gene/6238:CBG_19982 ^@ http://purl.uniprot.org/uniprot/A8XWV5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_09482 ^@ http://purl.uniprot.org/uniprot/A8X905 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty-acid and retinol-binding protein (FARBP) family.|||Secreted http://togogenome.org/gene/6238:CBG_10430 ^@ http://purl.uniprot.org/uniprot/A8XB71 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_07028 ^@ http://purl.uniprot.org/uniprot/A8X3V6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_00309 ^@ http://purl.uniprot.org/uniprot/A8WMN9 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane http://togogenome.org/gene/6238:CBG_01045 ^@ http://purl.uniprot.org/uniprot/A8WP12 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_05029 ^@ http://purl.uniprot.org/uniprot/A8WZ06 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_15124 ^@ http://purl.uniprot.org/uniprot/A8XLF4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/6238:CBG_05336 ^@ http://purl.uniprot.org/uniprot/A8WZM1 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.|||Binds 1 Mg(2+) ion per monomer.|||Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Nucleus http://togogenome.org/gene/6238:CBG_20801 ^@ http://purl.uniprot.org/uniprot/A8XYN2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_16350 ^@ http://purl.uniprot.org/uniprot/A8XNM4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6238:CBG_08544 ^@ http://purl.uniprot.org/uniprot/Q61MC6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the G-alpha family.|||G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.|||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. http://togogenome.org/gene/6238:CBG_00050 ^@ http://purl.uniprot.org/uniprot/A8WM75 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/6238:CBG_04558 ^@ http://purl.uniprot.org/uniprot/A8WXX4 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/6238:CBG_11404 ^@ http://purl.uniprot.org/uniprot/A8XD39 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_04620 ^@ http://purl.uniprot.org/uniprot/A8WY29 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/6238:CBG_18266 ^@ http://purl.uniprot.org/uniprot/A8XSA4 ^@ Similarity ^@ Belongs to the ABP1 family. http://togogenome.org/gene/6238:CBG_11571 ^@ http://purl.uniprot.org/uniprot/A8XDI7 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/6238:CBG_02476 ^@ http://purl.uniprot.org/uniprot/A8WU84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FARP (FMRFamide related peptide) family.|||FMRFamides and FMRFamide-like peptides are neuropeptides.|||Secreted http://togogenome.org/gene/6238:CBG_16309 ^@ http://purl.uniprot.org/uniprot/A8XNQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Mitochondrion http://togogenome.org/gene/6238:CBG_18957 ^@ http://purl.uniprot.org/uniprot/A8XUF7 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family. http://togogenome.org/gene/6238:CBG_04877 ^@ http://purl.uniprot.org/uniprot/A8WYP7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_13212 ^@ http://purl.uniprot.org/uniprot/A8XHB1 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/6238:CBG_09391 ^@ http://purl.uniprot.org/uniprot/Q67EQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/6238:CBG_18585 ^@ http://purl.uniprot.org/uniprot/A8XTM9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL38 family. http://togogenome.org/gene/6238:CBG_03822 ^@ http://purl.uniprot.org/uniprot/A8WWU1 ^@ Similarity ^@ Belongs to the LTV1 family. http://togogenome.org/gene/6238:CBG_05329 ^@ http://purl.uniprot.org/uniprot/A8WZL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/6238:CBG_18478 ^@ http://purl.uniprot.org/uniprot/A8XTE5 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/6238:CBG_16962 ^@ http://purl.uniprot.org/uniprot/A8XQ53 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_00405 ^@ http://purl.uniprot.org/uniprot/A8WN05 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/6238:CBG_03852 ^@ http://purl.uniprot.org/uniprot/A8WWX1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Interacts with, and is activated by, tap-1.|||Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Stimulates the wrm-1/lit-1-dependent phosphorylation of pop-1 and plays a role in the initial nuclear accumulation of wrm-1 (By similarity). http://togogenome.org/gene/6238:CBG_11466 ^@ http://purl.uniprot.org/uniprot/A8XCY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_19073 ^@ http://purl.uniprot.org/uniprot/Q60WL8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST5 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/6238:CBG_20955 ^@ http://purl.uniprot.org/uniprot/A8XZ14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sre family.|||Membrane http://togogenome.org/gene/6238:CBG_03199 ^@ http://purl.uniprot.org/uniprot/A8WSK3 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/6238:CBG_14608 ^@ http://purl.uniprot.org/uniprot/A8XKA3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/6238:CBG_12734 ^@ http://purl.uniprot.org/uniprot/A8XGG4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_01027 ^@ http://purl.uniprot.org/uniprot/A8WP28 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_14082 ^@ http://purl.uniprot.org/uniprot/Q619V5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the G-alpha family.|||G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.|||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. http://togogenome.org/gene/6238:CBG_17996 ^@ http://purl.uniprot.org/uniprot/A8XSS3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/6238:CBG_21705 ^@ http://purl.uniprot.org/uniprot/Q60QR6 ^@ Similarity ^@ Belongs to the TMA7 family. http://togogenome.org/gene/6238:CBG_04988 ^@ http://purl.uniprot.org/uniprot/A8WYX7 ^@ Similarity ^@ Belongs to the peptidase M13 family. http://togogenome.org/gene/6238:CBG_10057 ^@ http://purl.uniprot.org/uniprot/A8XAA1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2B alpha/beta/delta subunits family.|||Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.|||Complex of five different subunits; alpha, beta, gamma, delta and epsilon. http://togogenome.org/gene/6238:CBG_13321 ^@ http://purl.uniprot.org/uniprot/G2J6T4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-delta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/6238:CBG_09115 ^@ http://purl.uniprot.org/uniprot/E3CU08 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/6238:CBG_13890 ^@ http://purl.uniprot.org/uniprot/A8XJ39 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/6238:CBG_14781 ^@ http://purl.uniprot.org/uniprot/A8XKN3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_03419 ^@ http://purl.uniprot.org/uniprot/A8WV07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_15759 ^@ http://purl.uniprot.org/uniprot/Q615B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS10 family.|||Mitochondrion http://togogenome.org/gene/6238:CBG_01612 ^@ http://purl.uniprot.org/uniprot/A8WR88 ^@ Similarity ^@ Belongs to the CYFIP family. http://togogenome.org/gene/6238:CBG_06286 ^@ http://purl.uniprot.org/uniprot/A8X1V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty-acid and retinol-binding protein (FARBP) family.|||Secreted http://togogenome.org/gene/6238:CBG_03310 ^@ http://purl.uniprot.org/uniprot/A8WSB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/6238:CBG_09753 ^@ http://purl.uniprot.org/uniprot/Q61JK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP20 family.|||Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation.|||Nucleus|||centriole|||cilium axoneme|||cilium basal body http://togogenome.org/gene/6238:CBG_13200 ^@ http://purl.uniprot.org/uniprot/A8XHA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PEN-2 family.|||Membrane http://togogenome.org/gene/6238:CBG_04227 ^@ http://purl.uniprot.org/uniprot/A8WWG7 ^@ Similarity ^@ Belongs to the SPATS2 family. http://togogenome.org/gene/6238:CBG_10272 ^@ http://purl.uniprot.org/uniprot/A8XAQ5 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_19110 ^@ http://purl.uniprot.org/uniprot/G2J6Y9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KRR1 family.|||Component of the ribosomal small subunit (SSU) processome.|||Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.|||nucleolus http://togogenome.org/gene/6238:CBG_16323 ^@ http://purl.uniprot.org/uniprot/A8XNP3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_00730 ^@ http://purl.uniprot.org/uniprot/A8WN72 ^@ Similarity ^@ Belongs to the RdRP family. http://togogenome.org/gene/6238:CBG_15641 ^@ http://purl.uniprot.org/uniprot/A8XMF8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6238:CBG_01712 ^@ http://purl.uniprot.org/uniprot/A8WR08 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_17474 ^@ http://purl.uniprot.org/uniprot/A8XR42 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srg family. http://togogenome.org/gene/6238:CBG_14194 ^@ http://purl.uniprot.org/uniprot/A8XJH4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/6238:CBG_22267 ^@ http://purl.uniprot.org/uniprot/A8Y1X8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/6238:CBG_20020 ^@ http://purl.uniprot.org/uniprot/A8XWY3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_09465 ^@ http://purl.uniprot.org/uniprot/A8X916 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/6238:CBG_09566 ^@ http://purl.uniprot.org/uniprot/A8X8S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ro 60 kDa family.|||Cytoplasm http://togogenome.org/gene/6238:CBG_01307 ^@ http://purl.uniprot.org/uniprot/A8WQ37 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/6238:CBG_02462 ^@ http://purl.uniprot.org/uniprot/Q621J7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Although it is unknown whether it is a serine/threonine or a tyrosine protein kinase, it is strongly related to serine/threonine-protein kinase family.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.|||Protein kinase that plays a central role in centrosome duplication. Paternal copy is required to regulate synthesis of daughter centrioles prior to fertilization. Maternal copy regulates centrosome duplication during later cell cycles. Functions upstream of sas-5 and sas-6, and is required for their localization to the centrosome (By similarity).|||centriole http://togogenome.org/gene/6238:CBG_22765 ^@ http://purl.uniprot.org/uniprot/A8Y2U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||cytoskeleton http://togogenome.org/gene/6238:CBG_13260 ^@ http://purl.uniprot.org/uniprot/A8XHF2 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/6238:CBG_22337 ^@ http://purl.uniprot.org/uniprot/A8Y265 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_02799 ^@ http://purl.uniprot.org/uniprot/A8WTH5 ^@ Similarity ^@ Belongs to the UPF0729 family. http://togogenome.org/gene/6238:CBG_09769 ^@ http://purl.uniprot.org/uniprot/A8X9K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS31 family.|||Mitochondrion http://togogenome.org/gene/6238:CBG_08350 ^@ http://purl.uniprot.org/uniprot/A8X6D0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/6238:CBG_10211 ^@ http://purl.uniprot.org/uniprot/A8XAU7 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.|||Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.|||In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.|||Nucleus http://togogenome.org/gene/6238:CBG_20913 ^@ http://purl.uniprot.org/uniprot/A8XYX9 ^@ Similarity ^@ Belongs to the nanos family. http://togogenome.org/gene/6238:CBG_02555 ^@ http://purl.uniprot.org/uniprot/A8WU19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/6238:CBG_04030 ^@ http://purl.uniprot.org/uniprot/Q61XD3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.|||Chromosome|||Interacts with zen-4 and icp-1. Part of a complex containing at least air-2; icp-1; csc-1 and bir-1. Interacts with tlk-1 and bmk-1 (By similarity).|||Midbody|||Serine/threonine-protein kinase which mediates both meiotic and mitotic chromosome segregation. Required for histone H3 'Ser-10' phosphorylation. Phosphorylates tlk-1 and zen-4 (By similarity).|||cytoskeleton http://togogenome.org/gene/6238:CBG_21512 ^@ http://purl.uniprot.org/uniprot/A8Y0A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I LYR family.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_18323 ^@ http://purl.uniprot.org/uniprot/A8XSF5 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/6238:CBG_01668 ^@ http://purl.uniprot.org/uniprot/A8WR44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB1 family.|||Nucleus http://togogenome.org/gene/6238:CBG_20786 ^@ http://purl.uniprot.org/uniprot/E3CU83 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/6238:CBG_01903 ^@ http://purl.uniprot.org/uniprot/Q623D4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Msh homeobox family.|||Nucleus|||Probable transcription factor needed for the proper production of touch cell precursors. Essential for embryonic morphogenesis (By similarity). http://togogenome.org/gene/6238:CBG_18940 ^@ http://purl.uniprot.org/uniprot/A8XUE4 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/6238:CBG_21201 ^@ http://purl.uniprot.org/uniprot/A8XZM1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/6238:CBG_23401 ^@ http://purl.uniprot.org/uniprot/A8Y402 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srd family. http://togogenome.org/gene/6238:CBG_06035 ^@ http://purl.uniprot.org/uniprot/A8X120 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_12951 ^@ http://purl.uniprot.org/uniprot/A8XGR2 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/6238:CBG_14653 ^@ http://purl.uniprot.org/uniprot/Q618H8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS41 family.|||Early endosome|||Endosome membrane|||Late endosome|||Lysosome|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Within the HOPS complex, contributes to the normal development of gut granules in the adult intestine. May mediate the tethering of autophagosomes with lysosomes. Has a role in the negative regulation of apoptosis. Required for uptake of exogenous dsRNA which is used in experimental RNA silencing.|||Probable component of the homotypic fusion and vacuole protein sorting (HOPS) complex consisting of the core class C Vps proteins vps-11, vps-16, vps-18, and which further associates with vps-33.1, vps-39 and vps-41.|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/6238:CBG_23208 ^@ http://purl.uniprot.org/uniprot/A8Y4G3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_14362 ^@ http://purl.uniprot.org/uniprot/Q619C0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Essential for the proper assembly and activity of V-ATPase (By similarity). Required maternally for early embryogenesis and zygotically during morphogenesis. Specifically, involved in the clearance of apoptotic cell corpses in embryos. Also, during embryonic development, the V-ATPase is required to repress fusion of epidermal cells probably by negatively regulating eff-1-mediated cell fusion. In neurons, required for necrotic cell death by promoting intracellular acidification. Required for cell death induced by hypoxia. Required for acidification of synaptic vesicles and the release of neurotransmitters from adult neurons (By similarity).|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR. http://togogenome.org/gene/6238:CBG_19144 ^@ http://purl.uniprot.org/uniprot/A8XUX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_01521 ^@ http://purl.uniprot.org/uniprot/A8WQH7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/6238:CBG_09822 ^@ http://purl.uniprot.org/uniprot/A8X9Q7 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/6238:CBG_06344 ^@ http://purl.uniprot.org/uniprot/A8X208 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srd family. http://togogenome.org/gene/6238:CBG_13781 ^@ http://purl.uniprot.org/uniprot/A8XIP4 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_12757 ^@ http://purl.uniprot.org/uniprot/A8XGI2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_13541 ^@ http://purl.uniprot.org/uniprot/Q61B10 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GAR1 family.|||Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs).|||Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).|||nucleolus http://togogenome.org/gene/6238:CBG_10822 ^@ http://purl.uniprot.org/uniprot/A8XBV7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_07414 ^@ http://purl.uniprot.org/uniprot/A8X4T9 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_12349 ^@ http://purl.uniprot.org/uniprot/A8XFM4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.|||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. http://togogenome.org/gene/6238:CBG_09584 ^@ http://purl.uniprot.org/uniprot/A8X8R3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.|||Endoplasmic reticulum membrane|||Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (By similarity). http://togogenome.org/gene/6238:CBG_21033 ^@ http://purl.uniprot.org/uniprot/A8XZ79 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_14201 ^@ http://purl.uniprot.org/uniprot/A8XJI1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. http://togogenome.org/gene/6238:CBG_01507 ^@ http://purl.uniprot.org/uniprot/G2J6I6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_14895 ^@ http://purl.uniprot.org/uniprot/A8XKX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.|||Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_15477 ^@ http://purl.uniprot.org/uniprot/A8XM79 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_09010 ^@ http://purl.uniprot.org/uniprot/A8X808 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_23125 ^@ http://purl.uniprot.org/uniprot/A8Y4M9 ^@ Caution|||Similarity ^@ Belongs to the nematode receptor-like protein srg family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_14873 ^@ http://purl.uniprot.org/uniprot/A8XKW1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family. http://togogenome.org/gene/6238:CBG_11507 ^@ http://purl.uniprot.org/uniprot/A8XCU3 ^@ Similarity ^@ Belongs to the CCZ1 family. http://togogenome.org/gene/6238:CBG_11944 ^@ http://purl.uniprot.org/uniprot/G2J6Q7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22A family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_02289 ^@ http://purl.uniprot.org/uniprot/A8WUP0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. http://togogenome.org/gene/6238:CBG_07026 ^@ http://purl.uniprot.org/uniprot/A8X3V8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.|||Involved in the synthesis of catecholamines, such as dopamine. Has a role in serotonin signaling. Required for normal explorative and foraging behavior (By similarity).|||Phosphorylation leads to an increase in the catalytic activity.|||axon|||perinuclear region http://togogenome.org/gene/6238:CBG_20945 ^@ http://purl.uniprot.org/uniprot/A8XZ06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sre family.|||Membrane http://togogenome.org/gene/6238:CBG_09203 ^@ http://purl.uniprot.org/uniprot/Q9XTQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/6238:CBG_22525 ^@ http://purl.uniprot.org/uniprot/A8Y2H1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_20111 ^@ http://purl.uniprot.org/uniprot/A8XX43 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/6238:CBG_10097 ^@ http://purl.uniprot.org/uniprot/A8XAD8 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily. http://togogenome.org/gene/6238:CBG_01522 ^@ http://purl.uniprot.org/uniprot/A8WQH6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/6238:CBG_11067 ^@ http://purl.uniprot.org/uniprot/A8XCB9 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/6238:CBG_16248 ^@ http://purl.uniprot.org/uniprot/A8XNT6 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/6238:CBG_14894 ^@ http://purl.uniprot.org/uniprot/A8XKX5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_17971 ^@ http://purl.uniprot.org/uniprot/A8XSQ0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_16732 ^@ http://purl.uniprot.org/uniprot/Q612G6 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||Probable transcription factor. Required for muscle structure. Its dual subcellular localization suggests that it may function both as a muscle adhesion complex protein and as a transcription factor, or work together with transcription factors, to influence gene expression. Thought to act as a molecular bridge between unc-97 and mhc-a at the M-line of muscles, possibly in a signaling role (By similarity).|||The N-terminal part (1-106) mediates the nuclear localization, while the fourth zinc finger is required for the localization to M-lines and dense bodies. http://togogenome.org/gene/6238:CBG_11139 ^@ http://purl.uniprot.org/uniprot/A8XCJ4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_03579 ^@ http://purl.uniprot.org/uniprot/A8WVD7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/6238:CBG_21866 ^@ http://purl.uniprot.org/uniprot/Q60QD1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AAA ATPase family.|||Has a role in spindle assembly which acts in the progression through mitosis during embryogenesis. Required for fertility (By similarity).|||Hexamer.|||Nucleus http://togogenome.org/gene/6238:CBG_10919 ^@ http://purl.uniprot.org/uniprot/A8XC99 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_04031 ^@ http://purl.uniprot.org/uniprot/Q4VT38 ^@ Function|||Similarity|||Subunit ^@ Belongs to the G-alpha family.|||G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.|||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. http://togogenome.org/gene/6238:CBG_01801 ^@ http://purl.uniprot.org/uniprot/A8WQS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_03407 ^@ http://purl.uniprot.org/uniprot/A8WUZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_21170 ^@ http://purl.uniprot.org/uniprot/A8XZC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS26 family.|||Mitochondrion http://togogenome.org/gene/6238:CBG_10264 ^@ http://purl.uniprot.org/uniprot/A8XAR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_22506 ^@ http://purl.uniprot.org/uniprot/A8Y2F3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Membrane http://togogenome.org/gene/6238:CBG_07865 ^@ http://purl.uniprot.org/uniprot/A8X5B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/6238:CBG_18391 ^@ http://purl.uniprot.org/uniprot/A8XSL5 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/6238:CBG_03019 ^@ http://purl.uniprot.org/uniprot/B0K065 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_14665 ^@ http://purl.uniprot.org/uniprot/A8XKE5 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.|||The WWE domain mediates non-covalent poly(ADP-ribose)-binding.|||Ubiquitinated; autoubiquitinated.|||cytosol http://togogenome.org/gene/6238:CBG_11324 ^@ http://purl.uniprot.org/uniprot/A8XDA2 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/6238:CBG_11215 ^@ http://purl.uniprot.org/uniprot/Q61GH1 ^@ Similarity ^@ Belongs to the BCP1 family. http://togogenome.org/gene/6238:CBG_03025 ^@ http://purl.uniprot.org/uniprot/A8WSY5 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family. DPH2 subfamily.|||Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit. http://togogenome.org/gene/6238:CBG_05816 ^@ http://purl.uniprot.org/uniprot/A8X1K2 ^@ Similarity ^@ Belongs to the GST superfamily. Kappa family. http://togogenome.org/gene/6238:CBG_23183 ^@ http://purl.uniprot.org/uniprot/A8Y4I1 ^@ Similarity ^@ Belongs to the calcineurin regulatory subunit family. http://togogenome.org/gene/6238:CBG_04006 ^@ http://purl.uniprot.org/uniprot/B0K069 ^@ Similarity ^@ Belongs to the RdRP family. http://togogenome.org/gene/6238:CBG_07937 ^@ http://purl.uniprot.org/uniprot/A8X5E6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-6 family.|||Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. Involved in miRNA-mediated gene silencing.|||Cytoplasm|||Monomer. Associates with the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/6238:CBG_12376 ^@ http://purl.uniprot.org/uniprot/A8XFA3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS19 family. http://togogenome.org/gene/6238:CBG_05812 ^@ http://purl.uniprot.org/uniprot/A8X1K5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/6238:CBG_02923 ^@ http://purl.uniprot.org/uniprot/A8WT76 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_01504 ^@ http://purl.uniprot.org/uniprot/G2J6C3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_09646 ^@ http://purl.uniprot.org/uniprot/A8X8K4 ^@ Function|||Similarity ^@ Belongs to the E(R) family.|||May have a role in the cell cycle. http://togogenome.org/gene/6238:CBG_06108 ^@ http://purl.uniprot.org/uniprot/A8X0V9 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/6238:CBG_09046 ^@ http://purl.uniprot.org/uniprot/A8X7X9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the tryptophan 2,3-dioxygenase family.|||Binds 1 heme group per subunit.|||Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety (By similarity). Involved in regulation of protein homeostasis, longevity and reproducive life span. Specifically regulates proteotoxicity due to age-related aggregation of proteins like alpha-synuclein, via its effects on tryptophan metabolism (By similarity).|||Homotetramer. Dimer of dimers. http://togogenome.org/gene/6238:CBG_01524 ^@ http://purl.uniprot.org/uniprot/A0T3A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/6238:CBG_14519 ^@ http://purl.uniprot.org/uniprot/A8XK39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM135 family.|||Membrane http://togogenome.org/gene/6238:CBG_21000 ^@ http://purl.uniprot.org/uniprot/Q60S81 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Nicotinic acetylcholine receptor in the MC pharyngeal motor neuron involved in pharyngeal pumping. Has a role in the determination of life span possibly via calorific restriction which affects growth rate, although this is independent of metabolic activity (By similarity).|||Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.|||Cell membrane|||Neuronal AChR seems to be composed of two different type of subunits: alpha and beta.|||Postsynaptic cell membrane http://togogenome.org/gene/6238:CBG_15666 ^@ http://purl.uniprot.org/uniprot/A8XMH8 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. http://togogenome.org/gene/6238:CBG_23437 ^@ http://purl.uniprot.org/uniprot/G2J6I6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_07318 ^@ http://purl.uniprot.org/uniprot/A8X509 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/6238:CBG_07605 ^@ http://purl.uniprot.org/uniprot/A8X4G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FARP (FMRFamide related peptide) family.|||Secreted http://togogenome.org/gene/6238:CBG_10817 ^@ http://purl.uniprot.org/uniprot/G2J745 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_19415 ^@ http://purl.uniprot.org/uniprot/A8XVK2 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. http://togogenome.org/gene/6238:CBG_19304 ^@ http://purl.uniprot.org/uniprot/A8XVB2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_00383 ^@ http://purl.uniprot.org/uniprot/A8WMY6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/6238:CBG_14500 ^@ http://purl.uniprot.org/uniprot/A8XK26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lunapark family.|||Endoplasmic reticulum membrane|||Plays a role in tubular endoplasmic reticulum network formation and maintenance (By similarity). May be involved in central nervous system development. Has a presynaptic role in neurotransmission. Likely to operate in synaptogenesis by regulating vesicular transport or localization. Required for correct localization of rab-3 and snb-1 (By similarity). http://togogenome.org/gene/6238:CBG_21146 ^@ http://purl.uniprot.org/uniprot/A8XZD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein srb family.|||Membrane http://togogenome.org/gene/6238:CBG_01949 ^@ http://purl.uniprot.org/uniprot/A8WRN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_04192 ^@ http://purl.uniprot.org/uniprot/A8WWD9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOB1 family.|||May play a role in mRNA degradation.|||Nucleus http://togogenome.org/gene/6238:CBG_11576 ^@ http://purl.uniprot.org/uniprot/A8XDJ2 ^@ Function|||Similarity ^@ Belongs to the peptidase C65 family.|||Hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Specifically cleaves 'Lys-48'-linked polyubiquitin (By similarity). http://togogenome.org/gene/6238:CBG_08998 ^@ http://purl.uniprot.org/uniprot/A8X818 ^@ Function|||Similarity ^@ Belongs to the ATG12 family.|||Ubiquitin-like protein involved in autophagic vesicle formation. http://togogenome.org/gene/6238:CBG_10019 ^@ http://purl.uniprot.org/uniprot/A8XA68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/6238:CBG_22166 ^@ http://purl.uniprot.org/uniprot/A8Y1P8 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/6238:CBG_02432 ^@ http://purl.uniprot.org/uniprot/G2J6N5 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_15662 ^@ http://purl.uniprot.org/uniprot/A8XMH4 ^@ Similarity ^@ Belongs to the PHF5 family. http://togogenome.org/gene/6238:CBG_00525 ^@ http://purl.uniprot.org/uniprot/A8WNP5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6238:CBG_06221 ^@ http://purl.uniprot.org/uniprot/A8X0M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/6238:CBG_00209 ^@ http://purl.uniprot.org/uniprot/A8WMH2 ^@ Caution|||Similarity ^@ Belongs to the nematode receptor-like protein srg family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_08987 ^@ http://purl.uniprot.org/uniprot/A8X828 ^@ Similarity ^@ Belongs to the PAR3 family. http://togogenome.org/gene/6238:CBG_02667 ^@ http://purl.uniprot.org/uniprot/A8WTS8 ^@ Similarity ^@ Belongs to the cuticular collagen family. http://togogenome.org/gene/6238:CBG_02463 ^@ http://purl.uniprot.org/uniprot/A8WU97 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_19689 ^@ http://purl.uniprot.org/uniprot/A8XW74 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/6238:CBG_07641 ^@ http://purl.uniprot.org/uniprot/A8X4D9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_14124 ^@ http://purl.uniprot.org/uniprot/Q619T5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small GTPase superfamily. Rab family.|||Binds GTP and GDP. Plays a role in uterine seam cell development.|||Homodimer.|||perinuclear region http://togogenome.org/gene/6238:CBG_22845 ^@ http://purl.uniprot.org/uniprot/A8Y369 ^@ Similarity ^@ Belongs to the FAX family. http://togogenome.org/gene/6238:CBG_21354 ^@ http://purl.uniprot.org/uniprot/A8XZX0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/6238:CBG_02374 ^@ http://purl.uniprot.org/uniprot/A8WUH2 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. http://togogenome.org/gene/6238:CBG_09436 ^@ http://purl.uniprot.org/uniprot/A8X939 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/6238:CBG_08474 ^@ http://purl.uniprot.org/uniprot/A8X6M9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/6238:CBG_03254 ^@ http://purl.uniprot.org/uniprot/A8WSG2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/6238:CBG_12309 ^@ http://purl.uniprot.org/uniprot/A8XFI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_02208 ^@ http://purl.uniprot.org/uniprot/A8WSA2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/6238:CBG_18243 ^@ http://purl.uniprot.org/uniprot/A8XS83 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/6238:CBG_05522 ^@ http://purl.uniprot.org/uniprot/A8X027 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Su(H) family.|||Nucleus http://togogenome.org/gene/6238:CBG_03553 ^@ http://purl.uniprot.org/uniprot/A8WVB6 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_22599 ^@ http://purl.uniprot.org/uniprot/A8Y2M8 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6238:CBG_09006 ^@ http://purl.uniprot.org/uniprot/A8X811 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Antagonistic role in the Wnt signaling pathway that operates in embryogenesis (By similarity). When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation (By similarity). Has a role in blastomere signaling during endoderm specification (By similarity). Component of the beta-catenin-lit-1 complex which promotes phosphorylation, down-regulation and subcellular relocation of pop-1 (By similarity). Within the complex, activates lit-1-dependent kinase activity (By similarity). Can substitute for bar-1 indicating functional redundancy (By similarity). Appears to have a role in centrosome positioning (By similarity). Involved in the development of distal tip cells (DTC) by regulating the asymmetric distribution of cye-1 and cki-1 between the daughters of Z1.a and Z4.p cells (By similarity).|||Interacts (independently of ARM repeat) with nhr-25 (By similarity). Component of the beta-catenin-lit-1 complex (also called the lit-1/wrm-1 complex or the wrm-1/lit-1 kinase complex) at least composed of lit-1 and wrm-1 (By similarity). Interacts (via N-terminus) with lit-1; the interaction is direct and activates lit-1 kinase activity which leads to the phosphorylation of pop-1 (By similarity). This promotes pop-1 interaction with par-5 and translocation of pop-1 from the nucleus to the cytoplasm (By similarity).|||Nucleus|||cell cortex http://togogenome.org/gene/6238:CBG_06109 ^@ http://purl.uniprot.org/uniprot/A8X0V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF1 family.|||nucleolus http://togogenome.org/gene/6238:CBG_09563 ^@ http://purl.uniprot.org/uniprot/A8X8T2 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_14697 ^@ http://purl.uniprot.org/uniprot/G2J6V0 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/6238:CBG_03678 ^@ http://purl.uniprot.org/uniprot/A8WVK7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_11120 ^@ http://purl.uniprot.org/uniprot/A8XCG2 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/6238:CBG_18465 ^@ http://purl.uniprot.org/uniprot/A8XTD7 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. http://togogenome.org/gene/6238:CBG_10818 ^@ http://purl.uniprot.org/uniprot/A8XBV5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_06055 ^@ http://purl.uniprot.org/uniprot/G2J6F9 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_01814 ^@ http://purl.uniprot.org/uniprot/A8WQR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/6238:CBG_11069 ^@ http://purl.uniprot.org/uniprot/A8XCC1 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/6238:CBG_07972 ^@ http://purl.uniprot.org/uniprot/A8X5H5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.|||Monomer. Interacts with axl-1.|||Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting mesoderm development. Required for normal lifespan and LiCl-induced lifespan extension (By similarity). http://togogenome.org/gene/6238:CBG_23450 ^@ http://purl.uniprot.org/uniprot/A8Y3V9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_08064 ^@ http://purl.uniprot.org/uniprot/A8X5Q2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_02231 ^@ http://purl.uniprot.org/uniprot/A8WS81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/6238:CBG_09958 ^@ http://purl.uniprot.org/uniprot/A8XA17 ^@ Similarity|||Subunit ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.|||Homodimer. http://togogenome.org/gene/6238:CBG_04043 ^@ http://purl.uniprot.org/uniprot/A8WW26 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_06955 ^@ http://purl.uniprot.org/uniprot/A8X421 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/6238:CBG_13900 ^@ http://purl.uniprot.org/uniprot/A8XJ30 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/6238:CBG_08370 ^@ http://purl.uniprot.org/uniprot/A8X6E6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Heterodimer of a B chain and an A chain linked by two disulfide bonds.|||Secreted http://togogenome.org/gene/6238:CBG_21270 ^@ http://purl.uniprot.org/uniprot/A8XZQ8 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/6238:CBG_03319 ^@ http://purl.uniprot.org/uniprot/A8WUR9 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/6238:CBG_05731 ^@ http://purl.uniprot.org/uniprot/A8X1S3 ^@ Similarity ^@ Belongs to the glycosyltransferase 92 family. http://togogenome.org/gene/6238:CBG_21207 ^@ http://purl.uniprot.org/uniprot/Q60RS2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM16/PAM16 family.|||Mitochondrion inner membrane|||Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GrpE, tim-44, tim-16 and tim-14. Associates with the TIM23 complex.|||Regulates ATP-dependent protein translocation into the mitochondrial matrix.|||The J-like region, although related to the J domain does not have co-chaperone activity. http://togogenome.org/gene/6238:CBG_16565 ^@ http://purl.uniprot.org/uniprot/A8XPH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat TRM82 family.|||Forms a heterodimer with the catalytic subunit.|||Nucleus|||Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. http://togogenome.org/gene/6238:CBG_15255 ^@ http://purl.uniprot.org/uniprot/Q616J1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Orai family.|||Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, stim-1. Required for Ca(2+) and IP3-dependent contractile activity of sheath cells and the spermatheca. Affects brood size and somatic cell function (By similarity).|||Membrane http://togogenome.org/gene/6238:CBG_00557 ^@ http://purl.uniprot.org/uniprot/A8WNL4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/6238:CBG_12702 ^@ http://purl.uniprot.org/uniprot/A8XGD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_09700 ^@ http://purl.uniprot.org/uniprot/A8X8G7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.|||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. http://togogenome.org/gene/6238:CBG_13568 ^@ http://purl.uniprot.org/uniprot/A8XI74 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRK family.|||Interacts with ced-5 (via C-terminus which contains a candidate SH3-binding, proline-rich region). Forms a ternary complex with ced-5 and ced-12. Interacts (via SH-2 domain) with src-1 (when activated and phosphorylated at 'Tyr-416').|||Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Also has a role in the migration of the 2 gonadal distal tip cells (DTCs) (By similarity). http://togogenome.org/gene/6238:CBG_19227 ^@ http://purl.uniprot.org/uniprot/A8XV47 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Structural component of the gap junctions.|||gap junction http://togogenome.org/gene/6238:CBG_13065 ^@ http://purl.uniprot.org/uniprot/A8XH00 ^@ Similarity ^@ Belongs to the STRIP family. http://togogenome.org/gene/6238:CBG_20343 ^@ http://purl.uniprot.org/uniprot/G2J711 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/6238:CBG_18326 ^@ http://purl.uniprot.org/uniprot/A8XSF8 ^@ Similarity ^@ Belongs to the ANT/ATPSC lysine N-methyltransferase family. http://togogenome.org/gene/6238:CBG_17957 ^@ http://purl.uniprot.org/uniprot/A8XSN6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/6238:CBG_15050 ^@ http://purl.uniprot.org/uniprot/A8XLA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/6238:CBG_08386 ^@ http://purl.uniprot.org/uniprot/P34764 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Specifies differentiation of the set of six touch receptor neurons. Binds cooperatively as a heterodimer with unc-86 to sites in the mec-3 gene promoter. http://togogenome.org/gene/6238:CBG_02557 ^@ http://purl.uniprot.org/uniprot/A8WU18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/6238:CBG_23406 ^@ http://purl.uniprot.org/uniprot/A8Y3Z6 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/6238:CBG_03422 ^@ http://purl.uniprot.org/uniprot/A8WV10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||extracellular matrix http://togogenome.org/gene/6238:CBG_09764 ^@ http://purl.uniprot.org/uniprot/A8X9K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/6238:CBG_01779 ^@ http://purl.uniprot.org/uniprot/A8WQU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC3 family.|||Membrane http://togogenome.org/gene/6238:CBG_02547 ^@ http://purl.uniprot.org/uniprot/A8WU25 ^@ Similarity ^@ Belongs to the calsyntenin family. http://togogenome.org/gene/6238:CBG_06867 ^@ http://purl.uniprot.org/uniprot/Q27302 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the globin family.|||Cytoplasm|||It is uncertain whether Met-1 or Met-3 is the initiator.|||May be a globin and may play a role in oxygen transport. http://togogenome.org/gene/6238:CBG_06858 ^@ http://purl.uniprot.org/uniprot/A8X383 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/6238:CBG_00291 ^@ http://purl.uniprot.org/uniprot/A8WMM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/6238:CBG_07862 ^@ http://purl.uniprot.org/uniprot/A8X5A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/6238:CBG_22797 ^@ http://purl.uniprot.org/uniprot/A8Y2W6 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/6238:CBG_00143 ^@ http://purl.uniprot.org/uniprot/A8WMD6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Microsome membrane http://togogenome.org/gene/6238:CBG_09421 ^@ http://purl.uniprot.org/uniprot/A8X953 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_20579 ^@ http://purl.uniprot.org/uniprot/A8XY47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UVSSA family.|||Chromosome|||Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. http://togogenome.org/gene/6238:CBG_02878 ^@ http://purl.uniprot.org/uniprot/A8WTB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_07873 ^@ http://purl.uniprot.org/uniprot/A8X5B6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_05894 ^@ http://purl.uniprot.org/uniprot/A8X1E2 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/6238:CBG_00593 ^@ http://purl.uniprot.org/uniprot/A8WNI1 ^@ Similarity ^@ Belongs to the TIP family. http://togogenome.org/gene/6238:CBG_19953 ^@ http://purl.uniprot.org/uniprot/A8XWT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/6238:CBG_05989 ^@ http://purl.uniprot.org/uniprot/A8X162 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HRG family.|||Membrane http://togogenome.org/gene/6238:CBG_18761 ^@ http://purl.uniprot.org/uniprot/A8XU26 ^@ Similarity ^@ Belongs to the selenium-binding protein family. http://togogenome.org/gene/6238:CBG_00038 ^@ http://purl.uniprot.org/uniprot/A8WM68 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_06105 ^@ http://purl.uniprot.org/uniprot/A8X0W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_00041 ^@ http://purl.uniprot.org/uniprot/A8WM70 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6238:CBG_12497 ^@ http://purl.uniprot.org/uniprot/A8XFW6 ^@ Similarity ^@ Belongs to the MFAP1 family. http://togogenome.org/gene/6238:CBG_17919 ^@ http://purl.uniprot.org/uniprot/A8XS40 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_02625 ^@ http://purl.uniprot.org/uniprot/Q620W3 ^@ Similarity ^@ Belongs to the EFR3 family. http://togogenome.org/gene/6238:CBG_07928 ^@ http://purl.uniprot.org/uniprot/A8X5D8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_22306 ^@ http://purl.uniprot.org/uniprot/A8Y214 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||Structural component of the gap junctions.|||gap junction http://togogenome.org/gene/6238:CBG_16081 ^@ http://purl.uniprot.org/uniprot/A8XN53 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/6238:CBG_14797 ^@ http://purl.uniprot.org/uniprot/G2J6U9 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/6238:CBG_03709 ^@ http://purl.uniprot.org/uniprot/A8WWI5 ^@ Similarity ^@ Belongs to the nicastrin family. http://togogenome.org/gene/6238:CBG_14571 ^@ http://purl.uniprot.org/uniprot/A8XK79 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6238:CBG_03681 ^@ http://purl.uniprot.org/uniprot/A8WVK9 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/6238:CBG_12982 ^@ http://purl.uniprot.org/uniprot/A8XGT8 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/6238:CBG_07412 ^@ http://purl.uniprot.org/uniprot/A8X4U1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_15211 ^@ http://purl.uniprot.org/uniprot/A8XLN6 ^@ Similarity ^@ Belongs to the DEF8 family. http://togogenome.org/gene/6238:CBG_13182 ^@ http://purl.uniprot.org/uniprot/A8XH88 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_00033 ^@ http://purl.uniprot.org/uniprot/A8WM64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/6238:CBG_18395 ^@ http://purl.uniprot.org/uniprot/A8XSL9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6238:CBG_19302 ^@ http://purl.uniprot.org/uniprot/A8XVB0 ^@ Similarity ^@ Belongs to the MAD1 family. http://togogenome.org/gene/6238:CBG_23917 ^@ http://purl.uniprot.org/uniprot/A8WJK8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_08436 ^@ http://purl.uniprot.org/uniprot/A8X6J7 ^@ Similarity ^@ Belongs to the Mo25 family. http://togogenome.org/gene/6238:CBG_23190 ^@ http://purl.uniprot.org/uniprot/A8Y4H5 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/6238:CBG_16693 ^@ http://purl.uniprot.org/uniprot/A8XPM4 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/6238:CBG_04292 ^@ http://purl.uniprot.org/uniprot/A8WX61 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. http://togogenome.org/gene/6238:CBG_01212 ^@ http://purl.uniprot.org/uniprot/A8WPU8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_06235 ^@ http://purl.uniprot.org/uniprot/A8X0K6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/6238:CBG_17747 ^@ http://purl.uniprot.org/uniprot/A8XRE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_08253 ^@ http://purl.uniprot.org/uniprot/A8X654 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGU family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_07164 ^@ http://purl.uniprot.org/uniprot/A8X3K4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_09613 ^@ http://purl.uniprot.org/uniprot/A8X8N5 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_18211 ^@ http://purl.uniprot.org/uniprot/Q60YJ7 ^@ Similarity ^@ Belongs to the CSN12 family. http://togogenome.org/gene/6238:CBG_20738 ^@ http://purl.uniprot.org/uniprot/A8XYH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sre family.|||Membrane http://togogenome.org/gene/6238:CBG_22165 ^@ http://purl.uniprot.org/uniprot/A8Y1P7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Catalyzes the transfer of galactose onto proteins or lipids. Required for susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-2 and bre-3 (By similarity).|||Membrane http://togogenome.org/gene/6238:CBG_21755 ^@ http://purl.uniprot.org/uniprot/Q60QM6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/6238:CBG_12365 ^@ http://purl.uniprot.org/uniprot/A8XF93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reverse transcriptase family. Telomerase subfamily.|||Nucleus|||Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.|||telomere http://togogenome.org/gene/6238:CBG_13928 ^@ http://purl.uniprot.org/uniprot/A8XJ07 ^@ Similarity ^@ Belongs to the NAD kinase family. http://togogenome.org/gene/6238:CBG_23482 ^@ http://purl.uniprot.org/uniprot/A8Y3T5 ^@ Similarity ^@ Belongs to the FAX family. http://togogenome.org/gene/6238:CBG_02311 ^@ http://purl.uniprot.org/uniprot/A8WUM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC5 subfamily.|||Nucleus http://togogenome.org/gene/6238:CBG_19328 ^@ http://purl.uniprot.org/uniprot/A8XVD3 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_23120 ^@ http://purl.uniprot.org/uniprot/A8Y4N3 ^@ Caution|||Similarity ^@ Belongs to the nematode receptor-like protein srg family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_18416 ^@ http://purl.uniprot.org/uniprot/A8XT98 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_21024 ^@ http://purl.uniprot.org/uniprot/A8XZ71 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/6238:CBG_15225 ^@ http://purl.uniprot.org/uniprot/A8XLM3 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_10746 ^@ http://purl.uniprot.org/uniprot/A8XBP9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms chloride channels.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/6238:CBG_24746 ^@ http://purl.uniprot.org/uniprot/A8WLD9 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/6238:CBG_18300 ^@ http://purl.uniprot.org/uniprot/A8XSD5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 20 family. http://togogenome.org/gene/6238:CBG_14163 ^@ http://purl.uniprot.org/uniprot/A8XJF4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_06028 ^@ http://purl.uniprot.org/uniprot/A8X125 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-14 family.|||Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.|||Peroxisome membrane http://togogenome.org/gene/6238:CBG_23508 ^@ http://purl.uniprot.org/uniprot/A8Y3R5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/6238:CBG_17085 ^@ http://purl.uniprot.org/uniprot/A8XQF1 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/6238:CBG_18010 ^@ http://purl.uniprot.org/uniprot/A8XST6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. http://togogenome.org/gene/6238:CBG_04225 ^@ http://purl.uniprot.org/uniprot/A8WWG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.|||cytoskeleton http://togogenome.org/gene/6238:CBG_07042 ^@ http://purl.uniprot.org/uniprot/A8X3U6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_11199 ^@ http://purl.uniprot.org/uniprot/A8XCP5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_04060 ^@ http://purl.uniprot.org/uniprot/A8WW43 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_08827 ^@ http://purl.uniprot.org/uniprot/A8X7H4 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/6238:CBG_19394 ^@ http://purl.uniprot.org/uniprot/A8XVI9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_12818 ^@ http://purl.uniprot.org/uniprot/A8XFP3 ^@ Similarity ^@ Belongs to the proteasome subunit S5A family. http://togogenome.org/gene/6238:CBG_09381 ^@ http://purl.uniprot.org/uniprot/A8X981 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_17078 ^@ http://purl.uniprot.org/uniprot/A8XQF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_06639 ^@ http://purl.uniprot.org/uniprot/A8X2Q7 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/6238:CBG_13193 ^@ http://purl.uniprot.org/uniprot/A8XH96 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/6238:CBG_07578 ^@ http://purl.uniprot.org/uniprot/A8X4I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/6238:CBG_09344 ^@ http://purl.uniprot.org/uniprot/A8X9B5 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/6238:CBG_04294 ^@ http://purl.uniprot.org/uniprot/A8WX64 ^@ Similarity ^@ Belongs to the proteasome subunit p55 family. http://togogenome.org/gene/6238:CBG_18125 ^@ http://purl.uniprot.org/uniprot/A8XT29 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/6238:CBG_18033 ^@ http://purl.uniprot.org/uniprot/A8XSV7 ^@ Similarity ^@ Belongs to the E(R) family. http://togogenome.org/gene/6238:CBG_07436 ^@ http://purl.uniprot.org/uniprot/A8X4S0 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_10894 ^@ http://purl.uniprot.org/uniprot/A8XC78 ^@ Function|||Similarity ^@ Belongs to the sarcoglycan alpha/epsilon family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. http://togogenome.org/gene/6238:CBG_23795 ^@ http://purl.uniprot.org/uniprot/A8WJB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.|||Belongs to the DNA polymerase alpha subunit B family.|||Nucleus http://togogenome.org/gene/6238:CBG_12656 ^@ http://purl.uniprot.org/uniprot/A8XG97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/6238:CBG_07690 ^@ http://purl.uniprot.org/uniprot/A8X4A3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_11454 ^@ http://purl.uniprot.org/uniprot/A8XCZ4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_03202 ^@ http://purl.uniprot.org/uniprot/A8WSK1 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. http://togogenome.org/gene/6238:CBG_23978 ^@ http://purl.uniprot.org/uniprot/A8WJQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SID1 family.|||Membrane http://togogenome.org/gene/6238:CBG_22150 ^@ http://purl.uniprot.org/uniprot/A8Y1N3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. http://togogenome.org/gene/6238:CBG_18137 ^@ http://purl.uniprot.org/uniprot/A8XT37 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Mitochondrion inner membrane|||Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.|||This protein may be expected to contain an N-terminal transit peptide but none has been predicted. http://togogenome.org/gene/6238:CBG_03415 ^@ http://purl.uniprot.org/uniprot/A8WV03 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-beta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/6238:CBG_03104 ^@ http://purl.uniprot.org/uniprot/A8WSS5 ^@ Similarity ^@ Belongs to the adenylate kinase family. http://togogenome.org/gene/6238:CBG_19331 ^@ http://purl.uniprot.org/uniprot/A8XVD6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane|||May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.|||Membrane|||Microsome membrane http://togogenome.org/gene/6238:CBG_07064 ^@ http://purl.uniprot.org/uniprot/A8X3S7 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/6238:CBG_08009 ^@ http://purl.uniprot.org/uniprot/A8X5K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IMPACT family.|||Cytoplasm http://togogenome.org/gene/6238:CBG_01556 ^@ http://purl.uniprot.org/uniprot/A8WRD6 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/6238:CBG_08609 ^@ http://purl.uniprot.org/uniprot/A8X702 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_23361 ^@ http://purl.uniprot.org/uniprot/A8Y439 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/6238:CBG_02473 ^@ http://purl.uniprot.org/uniprot/A8WU86 ^@ Similarity ^@ Belongs to the FAX family. http://togogenome.org/gene/6238:CBG_20640 ^@ http://purl.uniprot.org/uniprot/A8XY98 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/6238:CBG_10811 ^@ http://purl.uniprot.org/uniprot/A8XBU8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits. http://togogenome.org/gene/6238:CBG_00999 ^@ http://purl.uniprot.org/uniprot/A8WP50 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_19026 ^@ http://purl.uniprot.org/uniprot/A8XUL5 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_08967 ^@ http://purl.uniprot.org/uniprot/A8X844 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/6238:CBG_08066 ^@ http://purl.uniprot.org/uniprot/A8X5Q3 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/6238:CBG_04832 ^@ http://purl.uniprot.org/uniprot/A8WYK9 ^@ Domain|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/6238:CBG_12234 ^@ http://purl.uniprot.org/uniprot/Q61E36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.|||Nucleus|||mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC (By similarity). http://togogenome.org/gene/6238:CBG_12341 ^@ http://purl.uniprot.org/uniprot/A8XFL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase g subunit family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. http://togogenome.org/gene/6238:CBG_11502 ^@ http://purl.uniprot.org/uniprot/A8XCU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/6238:CBG_11949 ^@ http://purl.uniprot.org/uniprot/A8XEN4 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/6238:CBG_05912 ^@ http://purl.uniprot.org/uniprot/A8X1C8 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/6238:CBG_20157 ^@ http://purl.uniprot.org/uniprot/A8XXA6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP11 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/6238:CBG_00359 ^@ http://purl.uniprot.org/uniprot/A8WMW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FARP (FMRFamide related peptide) family.|||Secreted http://togogenome.org/gene/6238:CBG_12473 ^@ http://purl.uniprot.org/uniprot/A8XFU5 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_12984 ^@ http://purl.uniprot.org/uniprot/A8XGU0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/6238:CBG_22843 ^@ http://purl.uniprot.org/uniprot/A8Y367 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_17481 ^@ http://purl.uniprot.org/uniprot/A8XR36 ^@ Caution|||Similarity ^@ Belongs to the nematode receptor-like protein srg family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_03460 ^@ http://purl.uniprot.org/uniprot/A8WV43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms chloride channels.|||Membrane http://togogenome.org/gene/6238:CBG_05166 ^@ http://purl.uniprot.org/uniprot/A8WZA2 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 2 family. http://togogenome.org/gene/6238:CBG_19214 ^@ http://purl.uniprot.org/uniprot/A8XV35 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_18398 ^@ http://purl.uniprot.org/uniprot/A8XSM1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_11457 ^@ http://purl.uniprot.org/uniprot/A8XCZ1 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/6238:CBG_06117 ^@ http://purl.uniprot.org/uniprot/A8X0V3 ^@ Similarity ^@ Belongs to the GTR/RAG GTP-binding protein family. http://togogenome.org/gene/6238:CBG_04990 ^@ http://purl.uniprot.org/uniprot/A8WYX9 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srd family. http://togogenome.org/gene/6238:CBG_02128 ^@ http://purl.uniprot.org/uniprot/A8WS14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/6238:CBG_04057 ^@ http://purl.uniprot.org/uniprot/A8WW40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/6238:CBG_17075 ^@ http://purl.uniprot.org/uniprot/A8XQF7 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/6238:CBG_00826 ^@ http://purl.uniprot.org/uniprot/A8WNX6 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/6238:CBG_14269 ^@ http://purl.uniprot.org/uniprot/A8XJM8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/6238:CBG_05752 ^@ http://purl.uniprot.org/uniprot/Q61TH2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer; composed of 3 copies of tim-9/tin-9.1 and 3 copies of tim-10/tin-10, named soluble 70 kDa complex. The complex associates with the tim-22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit (By similarity).|||Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of tim-9/tin-9.1 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity). http://togogenome.org/gene/6238:CBG_02512 ^@ http://purl.uniprot.org/uniprot/A8WU52 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_03992 ^@ http://purl.uniprot.org/uniprot/A8WVX9 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/6238:CBG_10510 ^@ http://purl.uniprot.org/uniprot/A8XAZ1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_05373 ^@ http://purl.uniprot.org/uniprot/A8WZQ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_06538 ^@ http://purl.uniprot.org/uniprot/A8X2H0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_20553 ^@ http://purl.uniprot.org/uniprot/A8XY26 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_13686 ^@ http://purl.uniprot.org/uniprot/A8XIH4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).|||Cytoplasm http://togogenome.org/gene/6238:CBG_06179 ^@ http://purl.uniprot.org/uniprot/A8X0Q9 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/6238:CBG_06820 ^@ http://purl.uniprot.org/uniprot/A8X354 ^@ Function|||Similarity ^@ Belongs to the NnrD/CARKD family.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. http://togogenome.org/gene/6238:CBG_12877 ^@ http://purl.uniprot.org/uniprot/A8XFT0 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/6238:CBG_08558 ^@ http://purl.uniprot.org/uniprot/A8X747 ^@ Similarity ^@ Belongs to the IST1 family. http://togogenome.org/gene/6238:CBG_14654 ^@ http://purl.uniprot.org/uniprot/A8XKD8 ^@ Similarity ^@ Belongs to the GPSM family. http://togogenome.org/gene/6238:CBG_10541 ^@ http://purl.uniprot.org/uniprot/A8XBE3 ^@ Similarity ^@ Belongs to the filamin family. http://togogenome.org/gene/6238:CBG_02509 ^@ http://purl.uniprot.org/uniprot/A8WU55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NSE2 family.|||Nucleus http://togogenome.org/gene/6238:CBG_12934 ^@ http://purl.uniprot.org/uniprot/A8XGQ2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.|||Cytoplasm|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of the anamorsin/DRE2 homolog, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. http://togogenome.org/gene/6238:CBG_21007 ^@ http://purl.uniprot.org/uniprot/A8XZ56 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_10908 ^@ http://purl.uniprot.org/uniprot/A8XC89 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/6238:CBG_09126 ^@ http://purl.uniprot.org/uniprot/A8X855 ^@ Function|||Similarity ^@ Belongs to the SKP1 family.|||Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. http://togogenome.org/gene/6238:CBG_01825 ^@ http://purl.uniprot.org/uniprot/A8WQQ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family.|||Component of the RNA exosome complex.|||Cytoplasm|||Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.|||Nucleus|||nucleolus http://togogenome.org/gene/6238:CBG_02664 ^@ http://purl.uniprot.org/uniprot/A8WTT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_23745 ^@ http://purl.uniprot.org/uniprot/A8WJ70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS39 family.|||Mitochondrion http://togogenome.org/gene/6238:CBG_05732 ^@ http://purl.uniprot.org/uniprot/A8X1S1 ^@ Similarity ^@ Belongs to the glycosyltransferase 92 family. http://togogenome.org/gene/6238:CBG_10981 ^@ http://purl.uniprot.org/uniprot/A8XBZ5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/6238:CBG_12266 ^@ http://purl.uniprot.org/uniprot/A8XF47 ^@ Similarity ^@ Belongs to the TIP41 family. http://togogenome.org/gene/6238:CBG_08837 ^@ http://purl.uniprot.org/uniprot/A8X7I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/6238:CBG_00365 ^@ http://purl.uniprot.org/uniprot/A8WMX2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_03052 ^@ http://purl.uniprot.org/uniprot/A8WSW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDCD10 family.|||Cytoplasm http://togogenome.org/gene/6238:CBG_08285 ^@ http://purl.uniprot.org/uniprot/A8X676 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/6238:CBG_01725 ^@ http://purl.uniprot.org/uniprot/A8WQZ9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/6238:CBG_22204 ^@ http://purl.uniprot.org/uniprot/A8Y1S5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_09177 ^@ http://purl.uniprot.org/uniprot/A8X887 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/6238:CBG_03821 ^@ http://purl.uniprot.org/uniprot/A8WWU0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit C family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/6238:CBG_17670 ^@ http://purl.uniprot.org/uniprot/A8XRK1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_23353 ^@ http://purl.uniprot.org/uniprot/A8Y444 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/6238:CBG_04059 ^@ http://purl.uniprot.org/uniprot/A8WW42 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/6238:CBG_12745 ^@ http://purl.uniprot.org/uniprot/A8XGH1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively. In RNA Pol II, this subunit is present in 2-fold molar excess over the other subunits (By similarity).|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity).|||Nucleus http://togogenome.org/gene/6238:CBG_01738 ^@ http://purl.uniprot.org/uniprot/A8WQY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit M family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-1 targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. Within the eIF-3 complex, interacts directly with eif-3.F. Component of the CSN complex, composed of csn-1, csn-2, csn-3, csn-4, csn-5, csn-6 and csn-7. Within the CSN complex, interacts directly with csn-1 and csn-4.|||Cytoplasm http://togogenome.org/gene/6238:CBG_07960 ^@ http://purl.uniprot.org/uniprot/A8X5G7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_09077 ^@ http://purl.uniprot.org/uniprot/Q61L47 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 15 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/6238:CBG_12498 ^@ http://purl.uniprot.org/uniprot/Q9U4H8 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/6238:CBG_15103 ^@ http://purl.uniprot.org/uniprot/A8Y210 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/6238:CBG_09879 ^@ http://purl.uniprot.org/uniprot/Q61J97 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyltransferase superfamily. METTL16/RlmF family.|||Nucleus|||RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating splicing of S-adenosylmethionine synthase transcripts (sams-3, sams-4 and sams-5). Able to N6-methylate a subset of mRNAs containing the 5'UACAGAAAC-3' nonamer sequence. Plays a key role in S-adenosyl-L-methionine homeostasis: under rich-diet conditions, catalyzes N6-methylation of S-adenosylmethionine synthase mRNAs (sams-3, sams-4 and sams-5), directly inhibiting splicing and protein production of S-adenosylmethionine synthase. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA). Required for gamete production, inhibiting germ cell proliferative fate and ensuring germ cell meiotic development. Also promotes progression of the mitotic cell cycle in those germ cells that continue to proliferate. Plays a role in the development of the vulva, somatic gonad and embryo.|||Self-associates. Interacts with dlc-1; the interaction is direct, and is required for nuclear localization of mett-10. http://togogenome.org/gene/6238:CBG_20641 ^@ http://purl.uniprot.org/uniprot/Q60T34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sra family.|||Membrane http://togogenome.org/gene/6238:CBG_16409 ^@ http://purl.uniprot.org/uniprot/A8XNI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_17284 ^@ http://purl.uniprot.org/uniprot/A8XQR7 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/6238:CBG_21173 ^@ http://purl.uniprot.org/uniprot/A8XZB9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/6238:CBG_20782 ^@ http://purl.uniprot.org/uniprot/E3CU82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family. CENP-S/MHF1 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/6238:CBG_18826 ^@ http://purl.uniprot.org/uniprot/A8XU70 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_04546 ^@ http://purl.uniprot.org/uniprot/A8WXW0 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_02293 ^@ http://purl.uniprot.org/uniprot/A8WUN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_03017 ^@ http://purl.uniprot.org/uniprot/A8WSZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Nup35 family.|||nuclear pore complex http://togogenome.org/gene/6238:CBG_14749 ^@ http://purl.uniprot.org/uniprot/A8XKL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_05830 ^@ http://purl.uniprot.org/uniprot/A8X1J1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6238:CBG_07740 ^@ http://purl.uniprot.org/uniprot/A8X467 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_18026 ^@ http://purl.uniprot.org/uniprot/A8XSV0 ^@ Caution|||Similarity ^@ In the N-terminal section; belongs to the FGAMS family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_04115 ^@ http://purl.uniprot.org/uniprot/A8WW88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/6238:CBG_05283 ^@ http://purl.uniprot.org/uniprot/A8WZJ2 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srd family. http://togogenome.org/gene/6238:CBG_20877 ^@ http://purl.uniprot.org/uniprot/A8XYV0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/6238:CBG_20155 ^@ http://purl.uniprot.org/uniprot/A8XXA8 ^@ Similarity ^@ Belongs to the SAP18 family. http://togogenome.org/gene/6238:CBG_19687 ^@ http://purl.uniprot.org/uniprot/A8XW72 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/6238:CBG_09535 ^@ http://purl.uniprot.org/uniprot/A8X8V6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_07149 ^@ http://purl.uniprot.org/uniprot/A8X3L4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_12913 ^@ http://purl.uniprot.org/uniprot/A8XGN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS4/SLD5 family.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication. http://togogenome.org/gene/6238:CBG_08723 ^@ http://purl.uniprot.org/uniprot/A8X790 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/6238:CBG_18921 ^@ http://purl.uniprot.org/uniprot/A8XUC8 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/6238:CBG_07481 ^@ http://purl.uniprot.org/uniprot/A8X4P3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/6238:CBG_18073 ^@ http://purl.uniprot.org/uniprot/A8XSZ1 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/6238:CBG_17914 ^@ http://purl.uniprot.org/uniprot/A8XS35 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_02089 ^@ http://purl.uniprot.org/uniprot/A8WRY7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_13670 ^@ http://purl.uniprot.org/uniprot/A8XIG1 ^@ Function|||Similarity ^@ Belongs to the TSR2 family.|||May be involved in 20S pre-rRNA processing. http://togogenome.org/gene/6238:CBG_04122 ^@ http://purl.uniprot.org/uniprot/Q61X54 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 1 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/6238:CBG_13757 ^@ http://purl.uniprot.org/uniprot/A8XIM3 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srd family. http://togogenome.org/gene/6238:CBG_13356 ^@ http://purl.uniprot.org/uniprot/A8XHY7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_23909 ^@ http://purl.uniprot.org/uniprot/A8WJK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/6238:CBG_01737 ^@ http://purl.uniprot.org/uniprot/Q623T0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-ketoglutarate dehydrogenase family.|||Mitochondrion matrix|||The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). http://togogenome.org/gene/6238:CBG_02544 ^@ http://purl.uniprot.org/uniprot/A8WU28 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_14680 ^@ http://purl.uniprot.org/uniprot/A8XKF8 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/6238:CBG_09073 ^@ http://purl.uniprot.org/uniprot/A8X7V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/6238:CBG_08178 ^@ http://purl.uniprot.org/uniprot/Q5WN23 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Membrane http://togogenome.org/gene/6238:CBG_09594 ^@ http://purl.uniprot.org/uniprot/A8X8Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat striatin family.|||Membrane http://togogenome.org/gene/6238:CBG_03788 ^@ http://purl.uniprot.org/uniprot/A8WWQ7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Cell projection|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Regulates cilium formation and structure.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. http://togogenome.org/gene/6238:CBG_06892 ^@ http://purl.uniprot.org/uniprot/A8X3A8 ^@ Similarity ^@ Belongs to the peroxin-19 family. http://togogenome.org/gene/6238:CBG_05755 ^@ http://purl.uniprot.org/uniprot/A8X1Q1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_00984 ^@ http://purl.uniprot.org/uniprot/A8WP63 ^@ Similarity ^@ Belongs to the peptidase C19 family. USP14/UBP6 subfamily. http://togogenome.org/gene/6238:CBG_12659 ^@ http://purl.uniprot.org/uniprot/A8XGA0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAD/OST2 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/6238:CBG_09650 ^@ http://purl.uniprot.org/uniprot/A8X8K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_12906 ^@ http://purl.uniprot.org/uniprot/A8XGM8 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6238:CBG_16142 ^@ http://purl.uniprot.org/uniprot/A8XP10 ^@ Similarity ^@ Belongs to the filamin family. http://togogenome.org/gene/6238:CBG_19978 ^@ http://purl.uniprot.org/uniprot/A8XWV1 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/6238:CBG_21547 ^@ http://purl.uniprot.org/uniprot/A8Y0C8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/6238:CBG_01326 ^@ http://purl.uniprot.org/uniprot/A8WQ54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sre family.|||Membrane http://togogenome.org/gene/6238:CBG_23481 ^@ http://purl.uniprot.org/uniprot/A8Y3T6 ^@ Similarity ^@ Belongs to the FAX family. http://togogenome.org/gene/6238:CBG_00852 ^@ http://purl.uniprot.org/uniprot/A8WPG8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase F subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/6238:CBG_24700 ^@ http://purl.uniprot.org/uniprot/A8WLA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NifU family.|||Mitochondrion|||Molecular scaffold for [Fe-S] cluster assembly of mitochondrial iron-sulfur proteins. http://togogenome.org/gene/6238:CBG_00883 ^@ http://purl.uniprot.org/uniprot/A8WPE5 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/6238:CBG_13393 ^@ http://purl.uniprot.org/uniprot/A8XHV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM86 family.|||Membrane http://togogenome.org/gene/6238:CBG_19412 ^@ http://purl.uniprot.org/uniprot/A8XVJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_23904 ^@ http://purl.uniprot.org/uniprot/A8WJJ7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/6238:CBG_00567 ^@ http://purl.uniprot.org/uniprot/A8WNK5 ^@ Function|||PTM|||Similarity ^@ Belongs to the eIF-5A family.|||Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group. http://togogenome.org/gene/6238:CBG_24766 ^@ http://purl.uniprot.org/uniprot/A8WLF5 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srd family. http://togogenome.org/gene/6238:CBG_10119 ^@ http://purl.uniprot.org/uniprot/A8XAF4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.|||E2-like enzyme which forms an intermediate with ufm-1. The intermediate is formed via a thioester linkage.|||Interacts with uba-5. http://togogenome.org/gene/6238:CBG_23903 ^@ http://purl.uniprot.org/uniprot/A8WJJ6 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/6238:CBG_16160 ^@ http://purl.uniprot.org/uniprot/A8XNZ7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6238:CBG_08024 ^@ http://purl.uniprot.org/uniprot/A8X5L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/6238:CBG_20989 ^@ http://purl.uniprot.org/uniprot/A8XZ42 ^@ Caution|||Similarity ^@ Belongs to the nematode receptor-like protein srg family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_00241 ^@ http://purl.uniprot.org/uniprot/A8WMJ2 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/6238:CBG_19435 ^@ http://purl.uniprot.org/uniprot/A8XVM0 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/6238:CBG_03472 ^@ http://purl.uniprot.org/uniprot/A8WV54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM144 family.|||Membrane http://togogenome.org/gene/6238:CBG_19671 ^@ http://purl.uniprot.org/uniprot/Q60V75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS16 family.|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Within the HOPS complex, contributes to the normal development of gut granules in the adult intestine. The CORVET complex is proposed to function as a rab-5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for recruitment of vps-33.1 to the HOPS complex. Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with vps-33.1 but not vps-33.2.|||Probable core component of at least two putative endosomal tethering complexes, the homotypic fusion and vacuole protein sorting (HOPS) complex and the class C core vacuole/endosome tethering (CORVET) complex. Their common core is composed of the class C Vps proteins vps-11, vps-16 and vps-18, which in HOPS further associates with vps-33.1, vps-39 and vps-41 and in CORVET with vps-8 and vps-33.2. http://togogenome.org/gene/6238:CBG_15226 ^@ http://purl.uniprot.org/uniprot/A8XLM4 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_19306 ^@ http://purl.uniprot.org/uniprot/G2J6C3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_11394 ^@ http://purl.uniprot.org/uniprot/A8XD45 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||nucleolus http://togogenome.org/gene/6238:CBG_19035 ^@ http://purl.uniprot.org/uniprot/Q4VT42 ^@ Function|||Similarity|||Subunit ^@ Belongs to the G-alpha family.|||G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.|||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. http://togogenome.org/gene/6238:CBG_13549 ^@ http://purl.uniprot.org/uniprot/A8XI59 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_11248 ^@ http://purl.uniprot.org/uniprot/A8XDF8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit H is essential for V-ATPase activity, but not for the assembly of the complex (By similarity).|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity). http://togogenome.org/gene/6238:CBG_07712 ^@ http://purl.uniprot.org/uniprot/A8X485 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the gob-1 trehalose phosphatase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the hydrolysis of trehalose 6-phosphate to trehalose and phosphate; prevents the accumulation of toxic levels of trehalose 6-phosphate. http://togogenome.org/gene/6238:CBG_23215 ^@ http://purl.uniprot.org/uniprot/A8Y4F8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NDC80/HEC1 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/6238:CBG_12437 ^@ http://purl.uniprot.org/uniprot/A8XFF8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_14904 ^@ http://purl.uniprot.org/uniprot/Q617N0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In neurons, required for necrotic cell death by promoting intracellular acidification (By similarity).|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR. http://togogenome.org/gene/6238:CBG_03027 ^@ http://purl.uniprot.org/uniprot/A8WSY8 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_09378 ^@ http://purl.uniprot.org/uniprot/A8X984 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MET18/MMS19 family.|||Component of the CIA complex.|||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.|||Nucleus|||spindle http://togogenome.org/gene/6238:CBG_05908 ^@ http://purl.uniprot.org/uniprot/A8X1D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/6238:CBG_22466 ^@ http://purl.uniprot.org/uniprot/P37164 ^@ Similarity ^@ In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family. http://togogenome.org/gene/6238:CBG_02573 ^@ http://purl.uniprot.org/uniprot/A8WU06 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_22296 ^@ http://purl.uniprot.org/uniprot/A8Y204 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/6238:CBG_04228 ^@ http://purl.uniprot.org/uniprot/A8WWG8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL1 family. http://togogenome.org/gene/6238:CBG_21183 ^@ http://purl.uniprot.org/uniprot/A8XZN7 ^@ Similarity ^@ Belongs to the CLEC16A/gop-1 family. http://togogenome.org/gene/6238:CBG_01026 ^@ http://purl.uniprot.org/uniprot/A8WP29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/6238:CBG_00671 ^@ http://purl.uniprot.org/uniprot/A8WNB6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL10 family. http://togogenome.org/gene/6238:CBG_08176 ^@ http://purl.uniprot.org/uniprot/A8X600 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/6238:CBG_03707 ^@ http://purl.uniprot.org/uniprot/A8WWI3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS19 family. http://togogenome.org/gene/6238:CBG_00931 ^@ http://purl.uniprot.org/uniprot/A8WPB0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARV1 family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.|||Membrane http://togogenome.org/gene/6238:CBG_05260 ^@ http://purl.uniprot.org/uniprot/A8WZH5 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/6238:CBG_11431 ^@ http://purl.uniprot.org/uniprot/A8XD13 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_09481 ^@ http://purl.uniprot.org/uniprot/A8X906 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty-acid and retinol-binding protein (FARBP) family.|||Secreted http://togogenome.org/gene/6238:CBG_14706 ^@ http://purl.uniprot.org/uniprot/A8XKH9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_19175 ^@ http://purl.uniprot.org/uniprot/A8XV03 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/6238:CBG_18317 ^@ http://purl.uniprot.org/uniprot/A8XSE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ran family.|||GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.|||Nucleus http://togogenome.org/gene/6238:CBG_22997 ^@ http://purl.uniprot.org/uniprot/A8Y3H3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Transfers N-acetylgalactosamine onto carbohydrate substrates. Involved in susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-3, bre-4, and bre-5. Involved in resistance to the nematotoxic C.cinerea galectin Cgl2. http://togogenome.org/gene/6238:CBG_03391 ^@ http://purl.uniprot.org/uniprot/A8WUY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/6238:CBG_20952 ^@ http://purl.uniprot.org/uniprot/A8XZ11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sre family.|||Membrane http://togogenome.org/gene/6238:CBG_03599 ^@ http://purl.uniprot.org/uniprot/A8WVF3 ^@ Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. http://togogenome.org/gene/6238:CBG_06842 ^@ http://purl.uniprot.org/uniprot/A8X371 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit D family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm|||The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.|||mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. http://togogenome.org/gene/6238:CBG_22107 ^@ http://purl.uniprot.org/uniprot/A8Y1J4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_00959 ^@ http://purl.uniprot.org/uniprot/A8WP85 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_08048 ^@ http://purl.uniprot.org/uniprot/A8X5N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/6238:CBG_23704 ^@ http://purl.uniprot.org/uniprot/A8WJ41 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Heterodimer of a catalytic subunit and an accessory subunit.|||Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). http://togogenome.org/gene/6238:CBG_21213 ^@ http://purl.uniprot.org/uniprot/A8XZK9 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_12586 ^@ http://purl.uniprot.org/uniprot/A8XG39 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/6238:CBG_13454 ^@ http://purl.uniprot.org/uniprot/A8XHQ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_13216 ^@ http://purl.uniprot.org/uniprot/A8XHB3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/6238:CBG_01728 ^@ http://purl.uniprot.org/uniprot/A8WQZ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.|||Cytoplasm|||S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha. http://togogenome.org/gene/6238:CBG_00451 ^@ http://purl.uniprot.org/uniprot/A8WN44 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_18607 ^@ http://purl.uniprot.org/uniprot/A8XTP8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_11851 ^@ http://purl.uniprot.org/uniprot/A8XE57 ^@ Function ^@ May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells. http://togogenome.org/gene/6238:CBG_24609 ^@ http://purl.uniprot.org/uniprot/A8WL34 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/6238:CBG_08351 ^@ http://purl.uniprot.org/uniprot/A8X6D1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/6238:CBG_11989 ^@ http://purl.uniprot.org/uniprot/A8XEA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-carbonic anhydrase family.|||Membrane|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/6238:CBG_01016 ^@ http://purl.uniprot.org/uniprot/A8WP37 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/6238:CBG_16139 ^@ http://purl.uniprot.org/uniprot/A8XP12 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/6238:CBG_14052 ^@ http://purl.uniprot.org/uniprot/A8XJ92 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6238:CBG_10781 ^@ http://purl.uniprot.org/uniprot/A8XBS6 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB4 subunit family.|||Complex I is composed of 45 different subunits. http://togogenome.org/gene/6238:CBG_05109 ^@ http://purl.uniprot.org/uniprot/A8WZ85 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. http://togogenome.org/gene/6238:CBG_14557 ^@ http://purl.uniprot.org/uniprot/A8XK68 ^@ Similarity ^@ Belongs to the vasopressin/oxytocin family. http://togogenome.org/gene/6238:CBG_08835 ^@ http://purl.uniprot.org/uniprot/A8X7I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/6238:CBG_08382 ^@ http://purl.uniprot.org/uniprot/A8X6F5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_09454 ^@ http://purl.uniprot.org/uniprot/A8X925 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/6238:CBG_15066 ^@ http://purl.uniprot.org/uniprot/A8XLB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP2 family.|||Membrane http://togogenome.org/gene/6238:CBG_06851 ^@ http://purl.uniprot.org/uniprot/A8X379 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S9 family.|||Component of the lid subcomplex of the 19S proteasome regulatory particle complex (also named PA700 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits (By similarity).|||Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.2 is required for proteasome assembly (By similarity). http://togogenome.org/gene/6238:CBG_09985 ^@ http://purl.uniprot.org/uniprot/A8XA38 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/6238:CBG_12593 ^@ http://purl.uniprot.org/uniprot/A8XG44 ^@ Similarity ^@ Belongs to the peptidase S8 family. Furin subfamily. http://togogenome.org/gene/6238:CBG_22344 ^@ http://purl.uniprot.org/uniprot/A8Y271 ^@ Similarity ^@ Belongs to the UPF0375 family. http://togogenome.org/gene/6238:CBG_13882 ^@ http://purl.uniprot.org/uniprot/A8XJ44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAMOX/DASOX family.|||Catalyzes oxidative deamination of D-amino acids, in particular D-alanine, and could be responsible for the degradation of diet-derived D-alanine in the intestine. Acts on a variety of D-amino acids with greater preference towards those with basic and aromatic groups followed by those bearing neutral groups. Has no activity against acidic D-amino acids, L-amino acids or N-methyl-L-aspartic acid. May play a role in egg-laying events and early development.|||Homodimer.|||Peroxisome http://togogenome.org/gene/6238:CBG_12482 ^@ http://purl.uniprot.org/uniprot/Q61DH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL24 family.|||Mitochondrion http://togogenome.org/gene/6238:CBG_10452 ^@ http://purl.uniprot.org/uniprot/A8XB91 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/6238:CBG_01550 ^@ http://purl.uniprot.org/uniprot/A8WRE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/6238:CBG_07766 ^@ http://purl.uniprot.org/uniprot/A8X448 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/6238:CBG_21918 ^@ http://purl.uniprot.org/uniprot/A8Y183 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NTAQ1 family.|||Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.|||Monomer. http://togogenome.org/gene/6238:CBG_05330 ^@ http://purl.uniprot.org/uniprot/A8WZL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_12568 ^@ http://purl.uniprot.org/uniprot/A8XG24 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/6238:CBG_18106 ^@ http://purl.uniprot.org/uniprot/A8XT17 ^@ Similarity ^@ Belongs to the GILT family. http://togogenome.org/gene/6238:CBG_12259 ^@ http://purl.uniprot.org/uniprot/A8XF42 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/6238:CBG_06670 ^@ http://purl.uniprot.org/uniprot/Q61RA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.|||Cytoplasm|||Nucleus|||Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Required for checkpoint mediated cell cycle arrest in response to DNA damage in germline cells. Essential for embryogenesis (By similarity). http://togogenome.org/gene/6238:CBG_22133 ^@ http://purl.uniprot.org/uniprot/A8Y1L6 ^@ Function|||Subcellular Location Annotation ^@ General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.|||Golgi apparatus|||Membrane|||Mitochondrion http://togogenome.org/gene/6238:CBG_12184 ^@ http://purl.uniprot.org/uniprot/A8XF17 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6238:CBG_07044 ^@ http://purl.uniprot.org/uniprot/A8X3U4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms chloride channels.|||Membrane http://togogenome.org/gene/6238:CBG_21508 ^@ http://purl.uniprot.org/uniprot/A8Y0A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Membrane http://togogenome.org/gene/6238:CBG_00476 ^@ http://purl.uniprot.org/uniprot/A8WMR2 ^@ Similarity ^@ Belongs to the acid ceramidase family. http://togogenome.org/gene/6238:CBG_12465 ^@ http://purl.uniprot.org/uniprot/A8XFI0 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/6238:CBG_18056 ^@ http://purl.uniprot.org/uniprot/A8XSX8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).|||Cytoplasm http://togogenome.org/gene/6238:CBG_16760 ^@ http://purl.uniprot.org/uniprot/A8XPR8 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/6238:CBG_06131 ^@ http://purl.uniprot.org/uniprot/A8X0U3 ^@ Similarity ^@ Belongs to the cuticular collagen family. http://togogenome.org/gene/6238:CBG_15879 ^@ http://purl.uniprot.org/uniprot/A8XN29 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_02998 ^@ http://purl.uniprot.org/uniprot/A8WT13 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC2 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Component of the origin recognition complex (ORC).|||Nucleus http://togogenome.org/gene/6238:CBG_09065 ^@ http://purl.uniprot.org/uniprot/A8X7W0 ^@ Similarity ^@ Belongs to the canopy family. http://togogenome.org/gene/6238:CBG_24500 ^@ http://purl.uniprot.org/uniprot/A8WKU8 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/6238:CBG_24535 ^@ http://purl.uniprot.org/uniprot/A8WKX5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/6238:CBG_06227 ^@ http://purl.uniprot.org/uniprot/A8X0L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/6238:CBG_15876 ^@ http://purl.uniprot.org/uniprot/A8XMU3 ^@ Similarity ^@ Belongs to the FAX family. http://togogenome.org/gene/6238:CBG_03753 ^@ http://purl.uniprot.org/uniprot/A8WWM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_22551 ^@ http://purl.uniprot.org/uniprot/A8Y2J4 ^@ Similarity ^@ Belongs to the SPARC family. http://togogenome.org/gene/6238:CBG_23906 ^@ http://purl.uniprot.org/uniprot/A8WJJ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_06367 ^@ http://purl.uniprot.org/uniprot/G2J6K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/6238:CBG_17653 ^@ http://purl.uniprot.org/uniprot/A8XRL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MOS2 family.|||Nucleus http://togogenome.org/gene/6238:CBG_09817 ^@ http://purl.uniprot.org/uniprot/A8X9Q2 ^@ Similarity ^@ Belongs to the PPC synthetase family. http://togogenome.org/gene/6238:CBG_17995 ^@ http://purl.uniprot.org/uniprot/A8XSS2 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_00142 ^@ http://purl.uniprot.org/uniprot/A8WMD5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acireductone dioxygenase (ARD) family.|||Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.|||Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.|||Cytoplasm|||Nucleus http://togogenome.org/gene/6238:CBG_20642 ^@ http://purl.uniprot.org/uniprot/A8XYA0 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/6238:CBG_21247 ^@ http://purl.uniprot.org/uniprot/A8XZI6 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/6238:CBG_18143 ^@ http://purl.uniprot.org/uniprot/A8XT41 ^@ Similarity ^@ Belongs to the PITHD1 family. http://togogenome.org/gene/6238:CBG_20699 ^@ http://purl.uniprot.org/uniprot/A8XYE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_08396 ^@ http://purl.uniprot.org/uniprot/A8X6G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/6238:CBG_23346 ^@ http://purl.uniprot.org/uniprot/A8Y451 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/6238:CBG_13275 ^@ http://purl.uniprot.org/uniprot/Q61BP6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer; composed of 3 copies of tim-9/tin-9.1 and 3 copies of tim-10/tin-10, named soluble 70 kDa complex. The complex associates with the tim-22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit (By similarity).|||Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of tim-10/tin-10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity). http://togogenome.org/gene/6238:CBG_03600 ^@ http://purl.uniprot.org/uniprot/A8WVF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC47 family.|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/6238:CBG_19174 ^@ http://purl.uniprot.org/uniprot/A8XV02 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/6238:CBG_15914 ^@ http://purl.uniprot.org/uniprot/A8XN24 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/6238:CBG_17482 ^@ http://purl.uniprot.org/uniprot/A8XR35 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srg family. http://togogenome.org/gene/6238:CBG_08845 ^@ http://purl.uniprot.org/uniprot/A8X7I8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_15672 ^@ http://purl.uniprot.org/uniprot/A8XMI2 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6238:CBG_16943 ^@ http://purl.uniprot.org/uniprot/A8XQ42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL54 family.|||Mitochondrion http://togogenome.org/gene/6238:CBG_23332 ^@ http://purl.uniprot.org/uniprot/A8Y461 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.|||Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/6238:CBG_15773 ^@ http://purl.uniprot.org/uniprot/A8XMR9 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Nucleus http://togogenome.org/gene/6238:CBG_04131 ^@ http://purl.uniprot.org/uniprot/A8WVM5 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/6238:CBG_16178 ^@ http://purl.uniprot.org/uniprot/A8XNY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTX family.|||Nucleus http://togogenome.org/gene/6238:CBG_03015 ^@ http://purl.uniprot.org/uniprot/A8WSZ7 ^@ Similarity ^@ Belongs to the VPS11 family. http://togogenome.org/gene/6238:CBG_03400 ^@ http://purl.uniprot.org/uniprot/A8WUY9 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/6238:CBG_17000 ^@ http://purl.uniprot.org/uniprot/A8XQ85 ^@ Similarity ^@ Belongs to the glycosyltransferase 92 family. http://togogenome.org/gene/6238:CBG_02894 ^@ http://purl.uniprot.org/uniprot/A8WT97 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/6238:CBG_17010 ^@ http://purl.uniprot.org/uniprot/A8XQ93 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_18031 ^@ http://purl.uniprot.org/uniprot/A8XSV5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ATPase B chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_04338 ^@ http://purl.uniprot.org/uniprot/A8WXB0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/6238:CBG_10126 ^@ http://purl.uniprot.org/uniprot/Q6E3D0 ^@ Function|||Subunit ^@ Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs. Essential for progression through meiosis. Involved in spermatogenesis (By similarity).|||Interacts with fbf-1. http://togogenome.org/gene/6238:CBG_20196 ^@ http://purl.uniprot.org/uniprot/A8XX81 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/6238:CBG_06250 ^@ http://purl.uniprot.org/uniprot/A8X0J4 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/6238:CBG_21343 ^@ http://purl.uniprot.org/uniprot/A8XZW1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS7 family. http://togogenome.org/gene/6238:CBG_11486 ^@ http://purl.uniprot.org/uniprot/A8XCW4 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/6238:CBG_01950 ^@ http://purl.uniprot.org/uniprot/A8WRN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphatidyl serine synthase family.|||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_06140 ^@ http://purl.uniprot.org/uniprot/A8X0T9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_08925 ^@ http://purl.uniprot.org/uniprot/A8X7P9 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/6238:CBG_12905 ^@ http://purl.uniprot.org/uniprot/A8XGM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_11768 ^@ http://purl.uniprot.org/uniprot/A8XE08 ^@ Similarity ^@ Belongs to the protein disulfide isomerase family. http://togogenome.org/gene/6238:CBG_19281 ^@ http://purl.uniprot.org/uniprot/A8XV90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FARP (FMRFamide related peptide) family.|||Secreted http://togogenome.org/gene/6238:CBG_10434 ^@ http://purl.uniprot.org/uniprot/A8XB74 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/6238:CBG_03313 ^@ http://purl.uniprot.org/uniprot/A8WUR4 ^@ Similarity ^@ Belongs to the UFD1 family. http://togogenome.org/gene/6238:CBG_12986 ^@ http://purl.uniprot.org/uniprot/A8XGU2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/6238:CBG_09810 ^@ http://purl.uniprot.org/uniprot/Q61JF9 ^@ Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the citrate synthase family.|||Citrate synthase is found in nearly all cells capable of oxidative metabolism.|||Homodimer.|||Mitochondrion matrix http://togogenome.org/gene/6238:CBG_23420 ^@ http://purl.uniprot.org/uniprot/A8Y3Y7 ^@ Similarity ^@ Belongs to the SMC family. RAD50 subfamily. http://togogenome.org/gene/6238:CBG_12770 ^@ http://purl.uniprot.org/uniprot/A8XGJ1 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/6238:CBG_03882 ^@ http://purl.uniprot.org/uniprot/A8WX00 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCA family.|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.|||Tubulin-folding protein; involved in the early step of the tubulin folding pathway.|||cytoskeleton http://togogenome.org/gene/6238:CBG_21741 ^@ http://purl.uniprot.org/uniprot/A8Y0L1 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/6238:CBG_19514 ^@ http://purl.uniprot.org/uniprot/A8XVS8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_08994 ^@ http://purl.uniprot.org/uniprot/A8X822 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/6238:CBG_02480 ^@ http://purl.uniprot.org/uniprot/A8WU80 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/6238:CBG_03362 ^@ http://purl.uniprot.org/uniprot/A8WUV5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/6238:CBG_18007 ^@ http://purl.uniprot.org/uniprot/A8XST3 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/6238:CBG_16503 ^@ http://purl.uniprot.org/uniprot/A8XPD0 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.|||Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. http://togogenome.org/gene/6238:CBG_00735 ^@ http://purl.uniprot.org/uniprot/A8WN68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sre family.|||Belongs to the sideroflexin family.|||Membrane http://togogenome.org/gene/6238:CBG_15628 ^@ http://purl.uniprot.org/uniprot/A8XME9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BRI3 family.|||Membrane|||perinuclear region http://togogenome.org/gene/6238:CBG_22319 ^@ http://purl.uniprot.org/uniprot/G2J679 ^@ Similarity ^@ Belongs to the MAPRE family. http://togogenome.org/gene/6238:CBG_02116 ^@ http://purl.uniprot.org/uniprot/A8WS09 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/6238:CBG_01395 ^@ http://purl.uniprot.org/uniprot/A8WQB4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_22996 ^@ http://purl.uniprot.org/uniprot/A8Y3H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/6238:CBG_09668 ^@ http://purl.uniprot.org/uniprot/A8X8I5 ^@ Function|||Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.|||Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. http://togogenome.org/gene/6238:CBG_21703 ^@ http://purl.uniprot.org/uniprot/A8Y0P5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/6238:CBG_13500 ^@ http://purl.uniprot.org/uniprot/A8XI14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SWEET sugar transporter family.|||Cell membrane|||Golgi apparatus membrane|||Mediates both low-affinity uptake and efflux of sugar across the membrane. http://togogenome.org/gene/6238:CBG_02296 ^@ http://purl.uniprot.org/uniprot/G2J6N5 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_22906 ^@ http://purl.uniprot.org/uniprot/A8Y3C0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_07451 ^@ http://purl.uniprot.org/uniprot/A8X4Q9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_07870 ^@ http://purl.uniprot.org/uniprot/A8X5B4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_20214 ^@ http://purl.uniprot.org/uniprot/A8XX64 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SH3BP5 family.|||Binds preferentially to the GDP-bound form of rab-11.1.|||Cytoplasmic granule|||Golgi apparatus membrane|||Guanine nucleotide exchange factor for Rab GTPase Rab-11.1. http://togogenome.org/gene/6238:CBG_01773 ^@ http://purl.uniprot.org/uniprot/A8WQV5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_00890 ^@ http://purl.uniprot.org/uniprot/A8WPE1 ^@ Similarity ^@ Belongs to the MPI phosphatase family. http://togogenome.org/gene/6238:CBG_13302 ^@ http://purl.uniprot.org/uniprot/A8XHI7 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/6238:CBG_23539 ^@ http://purl.uniprot.org/uniprot/A8Y3P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the battenin family.|||Membrane http://togogenome.org/gene/6238:CBG_09808 ^@ http://purl.uniprot.org/uniprot/A8X9P4 ^@ Similarity ^@ Belongs to the BLOC1S1 family. http://togogenome.org/gene/6238:CBG_19204 ^@ http://purl.uniprot.org/uniprot/A8XV27 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/6238:CBG_05504 ^@ http://purl.uniprot.org/uniprot/A8X014 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_03848 ^@ http://purl.uniprot.org/uniprot/A8WWW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_03993 ^@ http://purl.uniprot.org/uniprot/A8WVY0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/6238:CBG_03013 ^@ http://purl.uniprot.org/uniprot/A8WSZ9 ^@ Similarity ^@ Belongs to the SLBP family. http://togogenome.org/gene/6238:CBG_10415 ^@ http://purl.uniprot.org/uniprot/A8XB56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_16681 ^@ http://purl.uniprot.org/uniprot/A8XPB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/6238:CBG_03298 ^@ http://purl.uniprot.org/uniprot/A8WSC9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_22343 ^@ http://purl.uniprot.org/uniprot/A8Y270 ^@ Similarity ^@ Belongs to the UPF0375 family. http://togogenome.org/gene/6238:CBG_13348 ^@ http://purl.uniprot.org/uniprot/A8XHZ5 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/6238:CBG_23485 ^@ http://purl.uniprot.org/uniprot/A8Y3T3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_21589 ^@ http://purl.uniprot.org/uniprot/A8Y0G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/6238:CBG_04010 ^@ http://purl.uniprot.org/uniprot/A8WVZ2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_06337 ^@ http://purl.uniprot.org/uniprot/A8X201 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_05784 ^@ http://purl.uniprot.org/uniprot/A8X1M7 ^@ Similarity ^@ Belongs to the helicase family. http://togogenome.org/gene/6238:CBG_04328 ^@ http://purl.uniprot.org/uniprot/A8WX97 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_09319 ^@ http://purl.uniprot.org/uniprot/A8X9D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_08274 ^@ http://purl.uniprot.org/uniprot/A8X670 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/6238:CBG_12468 ^@ http://purl.uniprot.org/uniprot/A8XFI3 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/6238:CBG_10440 ^@ http://purl.uniprot.org/uniprot/A8XB80 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_14140 ^@ http://purl.uniprot.org/uniprot/A8XJE4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/6238:CBG_02223 ^@ http://purl.uniprot.org/uniprot/A8WS87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I NDUFB10 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_23216 ^@ http://purl.uniprot.org/uniprot/A8Y4F7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_04584 ^@ http://purl.uniprot.org/uniprot/A8WXZ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_21257 ^@ http://purl.uniprot.org/uniprot/A8XZP7 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/6238:CBG_17895 ^@ http://purl.uniprot.org/uniprot/A8XS18 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_20736 ^@ http://purl.uniprot.org/uniprot/A8XYH5 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/6238:CBG_04611 ^@ http://purl.uniprot.org/uniprot/A8WY21 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/6238:CBG_08019 ^@ http://purl.uniprot.org/uniprot/A8X5L4 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/6238:CBG_11891 ^@ http://purl.uniprot.org/uniprot/A8XE88 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_20595 ^@ http://purl.uniprot.org/uniprot/A8XY60 ^@ Similarity ^@ Belongs to the glycosyltransferase 92 family. http://togogenome.org/gene/6238:CBG_08733 ^@ http://purl.uniprot.org/uniprot/A8X796 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Membrane http://togogenome.org/gene/6238:CBG_12605 ^@ http://purl.uniprot.org/uniprot/A8XG52 ^@ Similarity ^@ Belongs to the FAM76 family. http://togogenome.org/gene/6238:CBG_20897 ^@ http://purl.uniprot.org/uniprot/A8XYW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/6238:CBG_00920 ^@ http://purl.uniprot.org/uniprot/A8WPB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/6238:CBG_08713 ^@ http://purl.uniprot.org/uniprot/A8X780 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/6238:CBG_11553 ^@ http://purl.uniprot.org/uniprot/A8XDH0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/6238:CBG_19969 ^@ http://purl.uniprot.org/uniprot/A8XWU5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_11988 ^@ http://purl.uniprot.org/uniprot/A8XEA2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ROX family. NO66 subfamily.|||Binds 1 Fe(2+) ion per subunit.|||Nucleus|||Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity). http://togogenome.org/gene/6238:CBG_02452 ^@ http://purl.uniprot.org/uniprot/A8WUA7 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. http://togogenome.org/gene/6238:CBG_05231 ^@ http://purl.uniprot.org/uniprot/A8WZF7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/6238:CBG_02629 ^@ http://purl.uniprot.org/uniprot/A8WTV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.|||Chromosome|||Histone methyltransferase that specifically di- and trimethylates 'Lys-20' of histone H4 (H4K20me2/me3). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Contributes to dosage compensation of X chromosome-relative to autosome-linked gene expression, possibly by converting H4K20me1 to H4K20m2/me3 on autosomes. Involved in the regulation of growth and body fat metabolism downstream of the TOR complex 2 pathway.|||Nucleus http://togogenome.org/gene/6238:CBG_23276 ^@ http://purl.uniprot.org/uniprot/A8Y4A7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_21200 ^@ http://purl.uniprot.org/uniprot/A8XZM2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRH/QCR6 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_00414 ^@ http://purl.uniprot.org/uniprot/A8WN13 ^@ Similarity ^@ Belongs to the COG2 family. http://togogenome.org/gene/6238:CBG_14921 ^@ http://purl.uniprot.org/uniprot/A8XL01 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tango11 family.|||Membrane|||Mitochondrion outer membrane|||Peroxisome|||Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. http://togogenome.org/gene/6238:CBG_08168 ^@ http://purl.uniprot.org/uniprot/A8X5Z2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_12070 ^@ http://purl.uniprot.org/uniprot/A8XEH5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. http://togogenome.org/gene/6238:CBG_10053 ^@ http://purl.uniprot.org/uniprot/A8XA97 ^@ Similarity ^@ Belongs to the NATD1 family. http://togogenome.org/gene/6238:CBG_12252 ^@ http://purl.uniprot.org/uniprot/A8XF36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom7 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/6238:CBG_15945 ^@ http://purl.uniprot.org/uniprot/A8XNF1 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/6238:CBG_17519 ^@ http://purl.uniprot.org/uniprot/A8XRD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_21324 ^@ http://purl.uniprot.org/uniprot/A8XZU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat PRP19 family.|||Homotetramer.|||Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.|||nucleoplasm http://togogenome.org/gene/6238:CBG_12686 ^@ http://purl.uniprot.org/uniprot/A8XGC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/6238:CBG_17505 ^@ http://purl.uniprot.org/uniprot/A8XRC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||trans-Golgi network membrane http://togogenome.org/gene/6238:CBG_02950 ^@ http://purl.uniprot.org/uniprot/A8WT51 ^@ Similarity ^@ Belongs to the GILT family. http://togogenome.org/gene/6238:CBG_12542 ^@ http://purl.uniprot.org/uniprot/A8XG03 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_10976 ^@ http://purl.uniprot.org/uniprot/A8XBZ2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_13308 ^@ http://purl.uniprot.org/uniprot/A8XHJ3 ^@ Similarity ^@ Belongs to the tRNA-intron endonuclease family. http://togogenome.org/gene/6238:CBG_16397 ^@ http://purl.uniprot.org/uniprot/A8XNJ0 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/6238:CBG_16008 ^@ http://purl.uniprot.org/uniprot/A8XNA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/6238:CBG_09830 ^@ http://purl.uniprot.org/uniprot/A8X9R4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/6238:CBG_16589 ^@ http://purl.uniprot.org/uniprot/A8XPJ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_08519 ^@ http://purl.uniprot.org/uniprot/A8X6R6 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_03712 ^@ http://purl.uniprot.org/uniprot/A8WWI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.|||Belongs to the mitochondrion-specific ribosomal protein mL64 family.|||Mitochondrion|||Nucleus http://togogenome.org/gene/6238:CBG_09443 ^@ http://purl.uniprot.org/uniprot/A8X933 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_07002 ^@ http://purl.uniprot.org/uniprot/A8X3Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.|||nucleolus http://togogenome.org/gene/6238:CBG_20816 ^@ http://purl.uniprot.org/uniprot/A8XYP4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_22606 ^@ http://purl.uniprot.org/uniprot/A8Y2N4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/6238:CBG_14077 ^@ http://purl.uniprot.org/uniprot/A8XJA7 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_00021 ^@ http://purl.uniprot.org/uniprot/A8WM57 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit A family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. http://togogenome.org/gene/6238:CBG_23440 ^@ http://purl.uniprot.org/uniprot/G2J745 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_03450 ^@ http://purl.uniprot.org/uniprot/A8WV34 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/6238:CBG_21823 ^@ http://purl.uniprot.org/uniprot/A8Y0W6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_08329 ^@ http://purl.uniprot.org/uniprot/A8X6B4 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/6238:CBG_10416 ^@ http://purl.uniprot.org/uniprot/A8XB57 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_22855 ^@ http://purl.uniprot.org/uniprot/A8Y379 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane|||May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.|||Membrane|||Microsome membrane http://togogenome.org/gene/6238:CBG_08081 ^@ http://purl.uniprot.org/uniprot/A8X5R6 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/6238:CBG_05531 ^@ http://purl.uniprot.org/uniprot/A8X034 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/6238:CBG_23348 ^@ http://purl.uniprot.org/uniprot/A8Y449 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/6238:CBG_05353 ^@ http://purl.uniprot.org/uniprot/A8WZN5 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_04366 ^@ http://purl.uniprot.org/uniprot/A8WXD4 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/6238:CBG_05883 ^@ http://purl.uniprot.org/uniprot/G2J745 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_13409 ^@ http://purl.uniprot.org/uniprot/A8XHU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sre family.|||Membrane http://togogenome.org/gene/6238:CBG_03706 ^@ http://purl.uniprot.org/uniprot/A8WWI2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_16182 ^@ http://purl.uniprot.org/uniprot/Q613V4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the G-alpha family.|||G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.|||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. May play a role in resistance to fungal infection in the epidermis by regulating the up-regulation of several antimicrobial peptides of the NLP and CNC families. Upstream of plc-3, egl-8, tpa-1 and the p38-like pathway, required for the expression of antimicrobial peptide nlp-29 in the epidermis in response to fungal infection or physical injury. http://togogenome.org/gene/6238:CBG_01505 ^@ http://purl.uniprot.org/uniprot/G2J6C6 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_07341 ^@ http://purl.uniprot.org/uniprot/A8X4Z2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_00621 ^@ http://purl.uniprot.org/uniprot/A8WNF7 ^@ Similarity ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. http://togogenome.org/gene/6238:CBG_11303 ^@ http://purl.uniprot.org/uniprot/A8XDC0 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/6238:CBG_18893 ^@ http://purl.uniprot.org/uniprot/A8XUA9 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/6238:CBG_16984 ^@ http://purl.uniprot.org/uniprot/A8XQ72 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_10414 ^@ http://purl.uniprot.org/uniprot/A8XB55 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_24679 ^@ http://purl.uniprot.org/uniprot/A8WL86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC5 family.|||Nucleus http://togogenome.org/gene/6238:CBG_22920 ^@ http://purl.uniprot.org/uniprot/A8Y3N6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_08546 ^@ http://purl.uniprot.org/uniprot/Q9GNN7 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||Participates in the inductive signaling pathway downstream of let-60 Ras and the RAF/MAP kinase cascade to regulate specification and differentiation of many cell types. Positively regulates the fate of vulval precursor cells. Required for induction of the P12 and excretory duct cell fates. In males, it is also required for proper formation of spicules. Does not function in the signaling pathway that promotes exit from pachytene (By similarity). http://togogenome.org/gene/6238:CBG_12179 ^@ http://purl.uniprot.org/uniprot/A8XF22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm http://togogenome.org/gene/6238:CBG_21660 ^@ http://purl.uniprot.org/uniprot/A8Y0T5 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/6238:CBG_10862 ^@ http://purl.uniprot.org/uniprot/A8XC58 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_21626 ^@ http://purl.uniprot.org/uniprot/A8Y086 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/6238:CBG_17370 ^@ http://purl.uniprot.org/uniprot/A8XQX3 ^@ Similarity ^@ Belongs to the VHL family. http://togogenome.org/gene/6238:CBG_02963 ^@ http://purl.uniprot.org/uniprot/A8WT38 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Cytoplasm|||LSm subunits form a heteromer with a donut shape.|||P-body|||Probably involved with other LSm subunits in the general process of degradation of mRNAs. http://togogenome.org/gene/6238:CBG_05259 ^@ http://purl.uniprot.org/uniprot/A8WZH4 ^@ Function|||Similarity ^@ Belongs to the SKP1 family.|||Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. http://togogenome.org/gene/6238:CBG_09216 ^@ http://purl.uniprot.org/uniprot/A8X8B7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_14965 ^@ http://purl.uniprot.org/uniprot/A8XL40 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/6238:CBG_23731 ^@ http://purl.uniprot.org/uniprot/A8WJ59 ^@ Similarity ^@ Belongs to the acetyltransferase family. NAA60 subfamily. http://togogenome.org/gene/6238:CBG_14540 ^@ http://purl.uniprot.org/uniprot/A8XK55 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6238:CBG_23205 ^@ http://purl.uniprot.org/uniprot/A8Y4G6 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_13497 ^@ http://purl.uniprot.org/uniprot/A8XI11 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum|||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins. http://togogenome.org/gene/6238:CBG_12714 ^@ http://purl.uniprot.org/uniprot/A8XGE5 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/6238:CBG_02833 ^@ http://purl.uniprot.org/uniprot/A8WTF0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/6238:CBG_02495 ^@ http://purl.uniprot.org/uniprot/A8WU67 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/6238:CBG_21017 ^@ http://purl.uniprot.org/uniprot/A8XZ64 ^@ Similarity|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Homodimer. http://togogenome.org/gene/6238:CBG_17647 ^@ http://purl.uniprot.org/uniprot/A8XRM2 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/6238:CBG_20714 ^@ http://purl.uniprot.org/uniprot/A8XYG0 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_03132 ^@ http://purl.uniprot.org/uniprot/A8WSQ5 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/6238:CBG_04188 ^@ http://purl.uniprot.org/uniprot/A8WWD5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS5 subunit family.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_13085 ^@ http://purl.uniprot.org/uniprot/A8XH19 ^@ Similarity ^@ Belongs to the PDE6D/unc-119 family. http://togogenome.org/gene/6238:CBG_09207 ^@ http://purl.uniprot.org/uniprot/A8X8C5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the DPH1/DPH2 family. DPH1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. http://togogenome.org/gene/6238:CBG_21891 ^@ http://purl.uniprot.org/uniprot/A8Y129 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/6238:CBG_09583 ^@ http://purl.uniprot.org/uniprot/A8X8R4 ^@ Similarity ^@ Belongs to the acetyltransferase family. GNA1 subfamily. http://togogenome.org/gene/6238:CBG_17901 ^@ http://purl.uniprot.org/uniprot/A8XS24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_24657 ^@ http://purl.uniprot.org/uniprot/A8WL66 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_16497 ^@ http://purl.uniprot.org/uniprot/A8XPC5 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_16731 ^@ http://purl.uniprot.org/uniprot/A8XPQ1 ^@ Similarity ^@ Belongs to the apyrase family. http://togogenome.org/gene/6238:CBG_09696 ^@ http://purl.uniprot.org/uniprot/A8X8H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sre family.|||Membrane http://togogenome.org/gene/6238:CBG_02597 ^@ http://purl.uniprot.org/uniprot/A8WTY7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_17672 ^@ http://purl.uniprot.org/uniprot/A8XRJ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_12495 ^@ http://purl.uniprot.org/uniprot/A8XFW4 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/6238:CBG_05401 ^@ http://purl.uniprot.org/uniprot/A8WZS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/6238:CBG_13432 ^@ http://purl.uniprot.org/uniprot/A8XHS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/6238:CBG_18645 ^@ http://purl.uniprot.org/uniprot/A8XTT0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_12026 ^@ http://purl.uniprot.org/uniprot/A8XED8 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/6238:CBG_02988 ^@ http://purl.uniprot.org/uniprot/A8WT17 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_19205 ^@ http://purl.uniprot.org/uniprot/A8XV28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/6238:CBG_01375 ^@ http://purl.uniprot.org/uniprot/A8WQ95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/6238:CBG_02947 ^@ http://purl.uniprot.org/uniprot/A8WT53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/6238:CBG_15750 ^@ http://purl.uniprot.org/uniprot/A8XMP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/6238:CBG_03029 ^@ http://purl.uniprot.org/uniprot/A8WSY6 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_08696 ^@ http://purl.uniprot.org/uniprot/A8X6S7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_14915 ^@ http://purl.uniprot.org/uniprot/Q617M0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM14 family.|||Mitochondrion inner membrane|||Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GrpE, tim-44, tim-16 and tim-14.|||Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). http://togogenome.org/gene/6238:CBG_11272 ^@ http://purl.uniprot.org/uniprot/A8XDE7 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/6238:CBG_18296 ^@ http://purl.uniprot.org/uniprot/A8XSD1 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/6238:CBG_19017 ^@ http://purl.uniprot.org/uniprot/A8XUK7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_06465 ^@ http://purl.uniprot.org/uniprot/A8X2A2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_14121 ^@ http://purl.uniprot.org/uniprot/A8XJC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ACDP family.|||Cell membrane|||Metal transporter. http://togogenome.org/gene/6238:CBG_06765 ^@ http://purl.uniprot.org/uniprot/A8X312 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_09317 ^@ http://purl.uniprot.org/uniprot/A8X9D8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_12256 ^@ http://purl.uniprot.org/uniprot/A8XF40 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/6238:CBG_23291 ^@ http://purl.uniprot.org/uniprot/A8Y494 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_12746 ^@ http://purl.uniprot.org/uniprot/A8XGH2 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/6238:CBG_04319 ^@ http://purl.uniprot.org/uniprot/A8WX86 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/6238:CBG_05966 ^@ http://purl.uniprot.org/uniprot/A8X178 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/6238:CBG_04632 ^@ http://purl.uniprot.org/uniprot/Q61VZ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad. This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization. The introduction of sperm triggers V-ATPase accumulation in proximal oocytes and induces lysosomal acidification which leads to engulfing of protein aggregates by lysosomes and subsequent clearance of the aggregates. Lysosomal acidification also leads to changes in mitochondrial morphology and function. Mitochondria in distal immature oocytes are fragmented, produce high levels of reactive oxygen species (ROS) and have high membrane potential, indicative of metabolic inactivity. In contrast, mitochondria in proximal mature oocytes are tubular with lower ROS levels and membrane potential, indicative of an active metabolic state required for aggregate mobilization before clearance. Involved in receptor-mediated endocytosis (By similarity).|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR. http://togogenome.org/gene/6238:CBG_18455 ^@ http://purl.uniprot.org/uniprot/A8XTC7 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/6238:CBG_21723 ^@ http://purl.uniprot.org/uniprot/A8Y0M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM CPSF6/7 family.|||Nucleus http://togogenome.org/gene/6238:CBG_05472 ^@ http://purl.uniprot.org/uniprot/A8WZY7 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/6238:CBG_20903 ^@ http://purl.uniprot.org/uniprot/A8XYX0 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/6238:CBG_14472 ^@ http://purl.uniprot.org/uniprot/A8XK08 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ATPase B chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_11380 ^@ http://purl.uniprot.org/uniprot/A8XD55 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_05897 ^@ http://purl.uniprot.org/uniprot/A8X1D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOSIP family.|||Nucleus http://togogenome.org/gene/6238:CBG_09697 ^@ http://purl.uniprot.org/uniprot/A8X8G9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_18198 ^@ http://purl.uniprot.org/uniprot/A8XS51 ^@ Subcellular Location Annotation ^@ P-body http://togogenome.org/gene/6238:CBG_01050 ^@ http://purl.uniprot.org/uniprot/A8WP07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/6238:CBG_02376 ^@ http://purl.uniprot.org/uniprot/A8WUH1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_02262 ^@ http://purl.uniprot.org/uniprot/A8WS53 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL10 family. http://togogenome.org/gene/6238:CBG_05470 ^@ http://purl.uniprot.org/uniprot/A8WZY5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. http://togogenome.org/gene/6238:CBG_13478 ^@ http://purl.uniprot.org/uniprot/A8XHN4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_04041 ^@ http://purl.uniprot.org/uniprot/A8WW24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNEP1R1 family.|||Cytoplasm|||Membrane|||Nucleus membrane http://togogenome.org/gene/6238:CBG_14577 ^@ http://purl.uniprot.org/uniprot/A8XK83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.|||Membrane http://togogenome.org/gene/6238:CBG_08993 ^@ http://purl.uniprot.org/uniprot/A8X823 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/6238:CBG_05885 ^@ http://purl.uniprot.org/uniprot/G2J6C3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_13878 ^@ http://purl.uniprot.org/uniprot/Q61A92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synembryn family.|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins independently of G-protein coupled receptors. Acts by exchanging bound GDP for free GTP. Also able to activate the G(s)-alpha in synaptic signaling network. Plays a key role in asymmetric spindle positioning, a step for asymmetric cell division that generates cell diversity during development by activating G(i) alpha protein goa-1 and gpa-16 independently of G-protein coupled receptors (By similarity).|||cell cortex http://togogenome.org/gene/6238:CBG_00962 ^@ http://purl.uniprot.org/uniprot/A8WP82 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family. http://togogenome.org/gene/6238:CBG_02483 ^@ http://purl.uniprot.org/uniprot/A8WU78 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_21507 ^@ http://purl.uniprot.org/uniprot/A8Y099 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS13 family. http://togogenome.org/gene/6238:CBG_01590 ^@ http://purl.uniprot.org/uniprot/A8WRA8 ^@ Similarity ^@ Belongs to the CENP-X/MHF2 family. http://togogenome.org/gene/6238:CBG_18646 ^@ http://purl.uniprot.org/uniprot/A8XTT1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_06174 ^@ http://purl.uniprot.org/uniprot/A8X0R4 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/6238:CBG_04258 ^@ http://purl.uniprot.org/uniprot/A8WX26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACC family.|||Cytoplasm http://togogenome.org/gene/6238:CBG_15242 ^@ http://purl.uniprot.org/uniprot/A8XLL2 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/6238:CBG_08416 ^@ http://purl.uniprot.org/uniprot/A8X6I2 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/6238:CBG_19213 ^@ http://purl.uniprot.org/uniprot/A8XV34 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_11531 ^@ http://purl.uniprot.org/uniprot/A8XCS2 ^@ Similarity ^@ Belongs to the TBCB family. http://togogenome.org/gene/6238:CBG_15244 ^@ http://purl.uniprot.org/uniprot/A8XLL0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FARP (FMRFamide related peptide) family.|||FMRFamides and FMRFamide-like peptides are neuropeptides.|||Secreted http://togogenome.org/gene/6238:CBG_07004 ^@ http://purl.uniprot.org/uniprot/A8X3Y0 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/6238:CBG_13047 ^@ http://purl.uniprot.org/uniprot/A8XGY6 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/6238:CBG_06116 ^@ http://purl.uniprot.org/uniprot/A8X0V4 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/6238:CBG_02259 ^@ http://purl.uniprot.org/uniprot/Q622B7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCTP family.|||Cytoplasm|||Involved in calcium binding and microtubule stabilization. http://togogenome.org/gene/6238:CBG_07944 ^@ http://purl.uniprot.org/uniprot/A8X5F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/6238:CBG_02729 ^@ http://purl.uniprot.org/uniprot/A8WTM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOC2 family.|||Nucleus|||Required for normal somatic gonad development and for regulation of germline development and proliferation. http://togogenome.org/gene/6238:CBG_17976 ^@ http://purl.uniprot.org/uniprot/A8XSQ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_06032 ^@ http://purl.uniprot.org/uniprot/A8X122 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.|||Belongs to the carbohydrate kinase PfkB family.|||Binds 3 Mg(2+) ions per subunit.|||Monomer.|||Nucleus http://togogenome.org/gene/6238:CBG_12675 ^@ http://purl.uniprot.org/uniprot/A8XGB4 ^@ Caution|||Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_15146 ^@ http://purl.uniprot.org/uniprot/Q616T6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL45 family.|||Mitochondrion http://togogenome.org/gene/6238:CBG_05730 ^@ http://purl.uniprot.org/uniprot/E3CTZ1 ^@ Similarity ^@ Belongs to the glycosyltransferase 92 family. http://togogenome.org/gene/6238:CBG_22771 ^@ http://purl.uniprot.org/uniprot/A8Y2V1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/6238:CBG_01661 ^@ http://purl.uniprot.org/uniprot/A8WR51 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/6238:CBG_15153 ^@ http://purl.uniprot.org/uniprot/P90726 ^@ Function|||Similarity ^@ Belongs to the small GTPase superfamily. Rab family.|||Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes (By similarity). http://togogenome.org/gene/6238:CBG_11024 ^@ http://purl.uniprot.org/uniprot/A8XC22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_04521 ^@ http://purl.uniprot.org/uniprot/A8WXP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/6238:CBG_07433 ^@ http://purl.uniprot.org/uniprot/Q8MUK2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6238:CBG_01241 ^@ http://purl.uniprot.org/uniprot/A8WPX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_07066 ^@ http://purl.uniprot.org/uniprot/A8X3S5 ^@ Similarity ^@ Belongs to the Tom22 family. http://togogenome.org/gene/6238:CBG_10904 ^@ http://purl.uniprot.org/uniprot/A8XC85 ^@ Similarity ^@ Belongs to the C19orf12 family. http://togogenome.org/gene/6238:CBG_20462 ^@ http://purl.uniprot.org/uniprot/A8XXU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPA family.|||Nucleus http://togogenome.org/gene/6238:CBG_08042 ^@ http://purl.uniprot.org/uniprot/Q5WNE3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transglutaminase-like superfamily. PNGase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Endoplasmic reticulum|||Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. Also displays oxidoreductase (thioredoxin) activity (By similarity). http://togogenome.org/gene/6238:CBG_23436 ^@ http://purl.uniprot.org/uniprot/G2J745 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_07219 ^@ http://purl.uniprot.org/uniprot/A8X3G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/6238:CBG_05881 ^@ http://purl.uniprot.org/uniprot/A8X1F4 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/6238:CBG_06061 ^@ http://purl.uniprot.org/uniprot/G2J745 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_10895 ^@ http://purl.uniprot.org/uniprot/A8XC79 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/6238:CBG_13346 ^@ http://purl.uniprot.org/uniprot/A8XHZ7 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/6238:CBG_23091 ^@ http://purl.uniprot.org/uniprot/A8Y4Q9 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/6238:CBG_16683 ^@ http://purl.uniprot.org/uniprot/A8XPB2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/6238:CBG_04590 ^@ http://purl.uniprot.org/uniprot/A8WY03 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM5 / TYW2 family.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Mitochondrion matrix|||Monomer.|||Nucleus|||Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. http://togogenome.org/gene/6238:CBG_17382 ^@ http://purl.uniprot.org/uniprot/A8XQY2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_01042 ^@ http://purl.uniprot.org/uniprot/Q626C1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNO1 family.|||Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.|||Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA.|||nucleolus http://togogenome.org/gene/6238:CBG_00981 ^@ http://purl.uniprot.org/uniprot/A8WP66 ^@ Function|||Similarity ^@ Belongs to the SMG8 family.|||Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes (By similarity). http://togogenome.org/gene/6238:CBG_06904 ^@ http://purl.uniprot.org/uniprot/A8X3B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the malectin family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_16385 ^@ http://purl.uniprot.org/uniprot/A8XNJ7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/6238:CBG_19964 ^@ http://purl.uniprot.org/uniprot/A8XWU0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 30 family. http://togogenome.org/gene/6238:CBG_11663 ^@ http://purl.uniprot.org/uniprot/A8XDR5 ^@ Developmental Stage|||Disruption Phenotype|||Function ^@ Expressed from early larval stages through to adulthood.|||Sex-determining factor which regulates hermaphrodite development.|||Temperature-sensitive phenotype in which XX animals are self-sterile, do not produce spermatocytes, but ovulate and produce progeny when mated with males; XO animals develop as males, but some switch to oogenesis in later life. Animals do not produce fog-3 proteins responsible for controlling germ cell fate. RNAi-mediated knock-down results in 95% female progeny. http://togogenome.org/gene/6238:CBG_03985 ^@ http://purl.uniprot.org/uniprot/Q61XH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSM3 family.|||Cytoplasm|||Nucleus|||Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. http://togogenome.org/gene/6238:CBG_06792 ^@ http://purl.uniprot.org/uniprot/A8X331 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_08772 ^@ http://purl.uniprot.org/uniprot/A8X7D0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/6238:CBG_15681 ^@ http://purl.uniprot.org/uniprot/A8XMI7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_17326 ^@ http://purl.uniprot.org/uniprot/Q9GNL2 ^@ Function|||PTM|||Subcellular Location Annotation ^@ Cleaved by caspase ced-3 in vitro.|||Heterochronic protein which controls the choice of stage specific cell fates. Involved in the temporal progression of vulval fate patterning, possibly by inhibiting lin-12. Acts as a transcription factor involved in the stage-specific repression of insulin/insulin-like growth factor gene ins-33.|||Nucleus http://togogenome.org/gene/6238:CBG_22023 ^@ http://purl.uniprot.org/uniprot/A8Y1C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 8 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/6238:CBG_23222 ^@ http://purl.uniprot.org/uniprot/A8Y4F3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/6238:CBG_03945 ^@ http://purl.uniprot.org/uniprot/A8WVT6 ^@ Similarity ^@ Belongs to the pyridoxine kinase family. http://togogenome.org/gene/6238:CBG_09961 ^@ http://purl.uniprot.org/uniprot/A8XA19 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/6238:CBG_17922 ^@ http://purl.uniprot.org/uniprot/A8XS42 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_14876 ^@ http://purl.uniprot.org/uniprot/A8XKW4 ^@ Function|||Similarity ^@ Belongs to the SKP1 family.|||Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. http://togogenome.org/gene/6238:CBG_18259 ^@ http://purl.uniprot.org/uniprot/A8XS98 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_24279 ^@ http://purl.uniprot.org/uniprot/A8WKD2 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/6238:CBG_18166 ^@ http://purl.uniprot.org/uniprot/A8XT62 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_03573 ^@ http://purl.uniprot.org/uniprot/A8WVD2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.|||Belongs to the WD repeat SEC13 family.|||Component of the nuclear pore complex (NPC). Probably part of the GATOR complex.|||Lysosome membrane|||Probable component of the nuclear pore complex (NPC) which is involved in the trafficking of macromolecules between the cytoplasm and nucleus.|||nuclear pore complex http://togogenome.org/gene/6238:CBG_20957 ^@ http://purl.uniprot.org/uniprot/A8XZ16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sre family.|||Membrane http://togogenome.org/gene/6238:CBG_13573 ^@ http://purl.uniprot.org/uniprot/A8XI77 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/6238:CBG_15231 ^@ http://purl.uniprot.org/uniprot/A8XLM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/6238:CBG_05277 ^@ http://purl.uniprot.org/uniprot/A8WZI7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_09569 ^@ http://purl.uniprot.org/uniprot/A8X8S6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||synaptosome http://togogenome.org/gene/6238:CBG_00535 ^@ http://purl.uniprot.org/uniprot/A8WNN5 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 56 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_02572 ^@ http://purl.uniprot.org/uniprot/A8WU07 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/6238:CBG_15626 ^@ http://purl.uniprot.org/uniprot/A8XME8 ^@ Function|||Similarity ^@ Belongs to the SKP1 family.|||Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. http://togogenome.org/gene/6238:CBG_15026 ^@ http://purl.uniprot.org/uniprot/A8XL83 ^@ Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family.|||Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences. http://togogenome.org/gene/6238:CBG_16997 ^@ http://purl.uniprot.org/uniprot/A8XQ82 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/6238:CBG_08843 ^@ http://purl.uniprot.org/uniprot/A8X7I6 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srd family. http://togogenome.org/gene/6238:CBG_08898 ^@ http://purl.uniprot.org/uniprot/A8X7M9 ^@ Function|||Similarity ^@ Belongs to the SKP1 family.|||Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. http://togogenome.org/gene/6238:CBG_15344 ^@ http://purl.uniprot.org/uniprot/A8XLZ8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/6238:CBG_09004 ^@ http://purl.uniprot.org/uniprot/Q61LA8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Alternates between an inactive GDP-bound form and an active GTP-bound form (By similarity). Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by GTPase-activating protein (GAP) (By similarity).|||Belongs to the small GTPase superfamily. Arf family.|||Golgi apparatus membrane|||Small GTPase involved in protein trafficking between different compartments. Modulates vesicle budding and uncoating within the Golgi complex. In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity). Involved in endoplasmic reticulum dynamics during embryogenesis. Also required for adult germline function. Plays a role in cell shedding during embryogenesis probably by promoting the endocytosis of cell adhesion molecules. During neurogenesis, involved in cell autonomous Q.p neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell, probably by controlling endocytosis. Plays a role in maintaining mitochondrial morphology (By similarity). http://togogenome.org/gene/6238:CBG_19014 ^@ http://purl.uniprot.org/uniprot/A8XUK5 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/6238:CBG_25150 ^@ http://purl.uniprot.org/uniprot/A8WUG5 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/6238:CBG_16944 ^@ http://purl.uniprot.org/uniprot/A8XQ43 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_03907 ^@ http://purl.uniprot.org/uniprot/A8WVQ3 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_00961 ^@ http://purl.uniprot.org/uniprot/A8WP83 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/6238:CBG_01251 ^@ http://purl.uniprot.org/uniprot/A8WPY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_01831 ^@ http://purl.uniprot.org/uniprot/A8WQP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.|||Membrane http://togogenome.org/gene/6238:CBG_22043 ^@ http://purl.uniprot.org/uniprot/A8Y1E5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/6238:CBG_10736 ^@ http://purl.uniprot.org/uniprot/A8XBP0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_18887 ^@ http://purl.uniprot.org/uniprot/A8XUA4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/6238:CBG_09267 ^@ http://purl.uniprot.org/uniprot/A8X9H6 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/6238:CBG_03530 ^@ http://purl.uniprot.org/uniprot/A8WV99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/6238:CBG_08259 ^@ http://purl.uniprot.org/uniprot/A8X658 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_17959 ^@ http://purl.uniprot.org/uniprot/A8XSN8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_04080 ^@ http://purl.uniprot.org/uniprot/A8WW60 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/6238:CBG_12907 ^@ http://purl.uniprot.org/uniprot/A8XGM9 ^@ Similarity ^@ Belongs to the ubiquitin family. http://togogenome.org/gene/6238:CBG_18052 ^@ http://purl.uniprot.org/uniprot/A8XSX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/6238:CBG_24605 ^@ http://purl.uniprot.org/uniprot/A8WL38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_05963 ^@ http://purl.uniprot.org/uniprot/A8X181 ^@ Activity Regulation|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the fic family.|||Endoplasmic reticulum membrane|||Forms homodimers; homodimerization might be required for adenylyltransferase activity.|||Nucleus membrane|||Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-273 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins. In vivo target proteins include the heat-shock 70 family proteins hsp-1 and hsp-3 and the translation elongation factors eef-1A, eef-1G and eef-2. Can AMPylate core histone H3 in vitro (By similarity). Can also act as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from target proteins (By similarity). Decreases susceptibility to P.aeruginosa-mediated killing and might therefore play a role in the innate immune response (By similarity).|||The fido domain mediates the adenylyltransferase activity.|||The side chain of Glu-273 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place. In response to endoplasmic reticulum stress, mediates de-AMPylase activity (By similarity). Adenylyltransferase activity is inhibited by the inhibitory helix present at the N-terminus: Glu-273 binds ATP and competes with ATP-binding at Arg-414, thereby preventing adenylyltransferase activity (By similarity). In unstressed cells, disengagement of Glu-273 promotes adenylyltransferase activity (By similarity). Activation dissociates ATP-binding from Glu-273, allowing ordered binding of the entire ATP moiety with the alpha-phosphate in an orientation that is productive for accepting an incoming target hydroxyl side chain (By similarity). http://togogenome.org/gene/6238:CBG_05839 ^@ http://purl.uniprot.org/uniprot/G2J6C3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_06840 ^@ http://purl.uniprot.org/uniprot/A8X369 ^@ Similarity ^@ Belongs to the CWC26 family. http://togogenome.org/gene/6238:CBG_03314 ^@ http://purl.uniprot.org/uniprot/A8WUR5 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/6238:CBG_06231 ^@ http://purl.uniprot.org/uniprot/A8X0L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/6238:CBG_20690 ^@ http://purl.uniprot.org/uniprot/A8XYD8 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/6238:CBG_03612 ^@ http://purl.uniprot.org/uniprot/Q9NBK4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL3 family.|||Cytoplasm|||The L3 protein is a component of the large subunit of cytoplasmic ribosomes. http://togogenome.org/gene/6238:CBG_01810 ^@ http://purl.uniprot.org/uniprot/A8WQR9 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_20323 ^@ http://purl.uniprot.org/uniprot/A8XXJ5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_17984 ^@ http://purl.uniprot.org/uniprot/A8XSR2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_01123 ^@ http://purl.uniprot.org/uniprot/A8WPL9 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srd family. http://togogenome.org/gene/6238:CBG_04574 ^@ http://purl.uniprot.org/uniprot/A8WXY8 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/6238:CBG_10989 ^@ http://purl.uniprot.org/uniprot/A8XC00 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/6238:CBG_02905 ^@ http://purl.uniprot.org/uniprot/A8WT90 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/6238:CBG_14927 ^@ http://purl.uniprot.org/uniprot/A8XL07 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/6238:CBG_09254 ^@ http://purl.uniprot.org/uniprot/A8X9I8 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/6238:CBG_10032 ^@ http://purl.uniprot.org/uniprot/A8XA80 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H3 family.|||Chromosome|||Cleaved at the onset of meiotic anaphase I, likely by separase sep-1.|||Forms a nucleosome-like histone octamer containing two molecules each of H2A, H2B, cpar-1 and H4 assembled in one cpar-1-H4 heterotetramer and two H2A-H2B heterodimers.|||Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Not required for chromosome segregation during meiosis.|||Nucleus http://togogenome.org/gene/6238:CBG_15725 ^@ http://purl.uniprot.org/uniprot/A8XMM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/6238:CBG_16407 ^@ http://purl.uniprot.org/uniprot/A8XNI3 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/6238:CBG_05064 ^@ http://purl.uniprot.org/uniprot/A8WZ33 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/6238:CBG_03006 ^@ http://purl.uniprot.org/uniprot/A8WT04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC2 subfamily.|||Nucleus http://togogenome.org/gene/6238:CBG_09777 ^@ http://purl.uniprot.org/uniprot/Q61JI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bL35 family.|||Mitochondrion http://togogenome.org/gene/6238:CBG_07161 ^@ http://purl.uniprot.org/uniprot/A8X3K7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_15297 ^@ http://purl.uniprot.org/uniprot/A8XLV9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_23471 ^@ http://purl.uniprot.org/uniprot/A8Y3U3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/6238:CBG_20639 ^@ http://purl.uniprot.org/uniprot/Q60T36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ A G protein-coupled receptor required for olfactory imprinting a requisite in ordorant response such as benzaldehyde and isoamylalcohol.|||Belongs to the nematode receptor-like protein sra family.|||Membrane http://togogenome.org/gene/6238:CBG_03063 ^@ http://purl.uniprot.org/uniprot/A8WSV7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.|||DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).|||Nucleus http://togogenome.org/gene/6238:CBG_12150 ^@ http://purl.uniprot.org/uniprot/A8XEV4 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/6238:CBG_20140 ^@ http://purl.uniprot.org/uniprot/A8XX59 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_15250 ^@ http://purl.uniprot.org/uniprot/A8XLK4 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/6238:CBG_16816 ^@ http://purl.uniprot.org/uniprot/A8XPV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Endoplasmic reticulum membrane|||Membrane|||Necessary for protein translocation in the endoplasmic reticulum. http://togogenome.org/gene/6238:CBG_08724 ^@ http://purl.uniprot.org/uniprot/A8X791 ^@ Similarity ^@ Belongs to the adaptor complexes medium subunit family. http://togogenome.org/gene/6238:CBG_04922 ^@ http://purl.uniprot.org/uniprot/A8WYT3 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/6238:CBG_14929 ^@ http://purl.uniprot.org/uniprot/A8XL09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/6238:CBG_09850 ^@ http://purl.uniprot.org/uniprot/A8X9T2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA8 subunit family.|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/6238:CBG_07560 ^@ http://purl.uniprot.org/uniprot/A8X4K1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/6238:CBG_03282 ^@ http://purl.uniprot.org/uniprot/Q61Z40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GILT family.|||Secreted http://togogenome.org/gene/6238:CBG_23195 ^@ http://purl.uniprot.org/uniprot/A8Y4H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/6238:CBG_18938 ^@ http://purl.uniprot.org/uniprot/A8XUE2 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/6238:CBG_16614 ^@ http://purl.uniprot.org/uniprot/Q612Q9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS21 family.|||Component of the 40S small ribosomal subunit.|||Cytoplasm|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/6238:CBG_00135 ^@ http://purl.uniprot.org/uniprot/Q628Z2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Calcium-dependent mitochondrial solute carrier.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_02622 ^@ http://purl.uniprot.org/uniprot/A8WTW4 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/6238:CBG_06153 ^@ http://purl.uniprot.org/uniprot/A8X0S9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6238:CBG_02091 ^@ http://purl.uniprot.org/uniprot/A8WRY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/6238:CBG_08494 ^@ http://purl.uniprot.org/uniprot/A8X6P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family.|||Cytoplasm http://togogenome.org/gene/6238:CBG_14386 ^@ http://purl.uniprot.org/uniprot/A8XJW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/6238:CBG_22401 ^@ http://purl.uniprot.org/uniprot/A8Y256 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC7 family.|||Nucleus http://togogenome.org/gene/6238:CBG_15975 ^@ http://purl.uniprot.org/uniprot/A8XND4 ^@ Domain|||Similarity ^@ Belongs to the CAMSAP1 family.|||The CKK domain binds microtubules. http://togogenome.org/gene/6238:CBG_01948 ^@ http://purl.uniprot.org/uniprot/A8WRN2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_22761 ^@ http://purl.uniprot.org/uniprot/A8Y2U2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts downstream of ced-9 and caspase ced-3 to promote phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Regulates apoptosis kinetics during embryonic development. Not required for engulfment of germ cell corpses.|||Belongs to the XK family.|||Cell membrane|||Cleavage by ced-3 activates ced-8 function in promoting phosphatidylserine exposure at the surface of apoptotic cells. http://togogenome.org/gene/6238:CBG_23424 ^@ http://purl.uniprot.org/uniprot/A8Y3Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/6238:CBG_20882 ^@ http://purl.uniprot.org/uniprot/A8XYV4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_10309 ^@ http://purl.uniprot.org/uniprot/A8XAM7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_18095 ^@ http://purl.uniprot.org/uniprot/Q60YT6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome b5 family. MAPR subfamily.|||Heme-binding protein.|||Secreted|||The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residues at position 136 and 169. http://togogenome.org/gene/6238:CBG_18087 ^@ http://purl.uniprot.org/uniprot/Q60YU0 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. LCMT family.|||Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. http://togogenome.org/gene/6238:CBG_03702 ^@ http://purl.uniprot.org/uniprot/A8WWI0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/6238:CBG_08424 ^@ http://purl.uniprot.org/uniprot/A8X6I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM241 family.|||Membrane http://togogenome.org/gene/6238:CBG_18096 ^@ http://purl.uniprot.org/uniprot/Q60YT5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with the cullin cul-3. Interacts with ubiquitin via its UBA-like domain. Interacts with ned-8/nedd8 (By similarity).|||Nucleus|||Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with rbx-1 to recruit the Nedd8-charged E2 enzyme to the cullin component of SCF-type complexes (By similarity). http://togogenome.org/gene/6238:CBG_16855 ^@ http://purl.uniprot.org/uniprot/A8XPY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/6238:CBG_22979 ^@ http://purl.uniprot.org/uniprot/Q60MW2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SPCS3 family.|||Component of the signal peptidase complex (SPC) composed of a catalytic subunit sec-11 and three accessory subunits spcs-1, spcs-2 and spcs-3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids.|||Endoplasmic reticulum membrane|||Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity). http://togogenome.org/gene/6238:CBG_09029 ^@ http://purl.uniprot.org/uniprot/A8X7Z5 ^@ Subcellular Location Annotation ^@ adherens junction http://togogenome.org/gene/6238:CBG_18162 ^@ http://purl.uniprot.org/uniprot/Q60YN5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BRE1 family.|||E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B (By similarity). H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (By similarity). Involved in regulating stem cell proliferative fate (By similarity).|||Interacts with ubc-1 (By similarity). Interacts with mrg-1 (By similarity).|||Nucleus http://togogenome.org/gene/6238:CBG_24741 ^@ http://purl.uniprot.org/uniprot/A8WLD4 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/6238:CBG_01235 ^@ http://purl.uniprot.org/uniprot/A8WPX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_19040 ^@ http://purl.uniprot.org/uniprot/A8XUM7 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/6238:CBG_14886 ^@ http://purl.uniprot.org/uniprot/A8XKX0 ^@ Similarity ^@ Belongs to the WD repeat L(2)GL family. http://togogenome.org/gene/6238:CBG_10035 ^@ http://purl.uniprot.org/uniprot/A8XA82 ^@ Function|||Similarity ^@ Belongs to the tubulin family.|||Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. http://togogenome.org/gene/6238:CBG_22235 ^@ http://purl.uniprot.org/uniprot/A8Y1U9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/6238:CBG_21269 ^@ http://purl.uniprot.org/uniprot/A8XZQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/6238:CBG_24678 ^@ http://purl.uniprot.org/uniprot/A8WL85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Chromosome|||Nucleus http://togogenome.org/gene/6238:CBG_01012 ^@ http://purl.uniprot.org/uniprot/A8WP41 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/6238:CBG_20815 ^@ http://purl.uniprot.org/uniprot/A8XYP3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_20198 ^@ http://purl.uniprot.org/uniprot/A8XX79 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/6238:CBG_06922 ^@ http://purl.uniprot.org/uniprot/A8X3D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/6238:CBG_09432 ^@ http://purl.uniprot.org/uniprot/A8X943 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_11974 ^@ http://purl.uniprot.org/uniprot/A8XEQ5 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/6238:CBG_17504 ^@ http://purl.uniprot.org/uniprot/A8XRC1 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/6238:CBG_00121 ^@ http://purl.uniprot.org/uniprot/A8WMB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/6238:CBG_21051 ^@ http://purl.uniprot.org/uniprot/A8XZA8 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. http://togogenome.org/gene/6238:CBG_04164 ^@ http://purl.uniprot.org/uniprot/A8WWB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_20818 ^@ http://purl.uniprot.org/uniprot/A8XYP5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_18807 ^@ http://purl.uniprot.org/uniprot/A8XU56 ^@ Cofactor|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/6238:CBG_09321 ^@ http://purl.uniprot.org/uniprot/A8X9D4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_18025 ^@ http://purl.uniprot.org/uniprot/A8XSU9 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/6238:CBG_16979 ^@ http://purl.uniprot.org/uniprot/A8XQ67 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_04928 ^@ http://purl.uniprot.org/uniprot/A8WYT9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_18600 ^@ http://purl.uniprot.org/uniprot/Q60XN1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription.|||Cytoplasm|||Forms a complex composed of deubiquitinating enzyme atx-3, adapter ubxn-5 and cdc-48.1. Forms a complex composed of deubiquitinating enzyme atx-3, E4 ubiquitin-protein ligase ufd-2 and cdc-48.1. Interacts (via RRDR motif) with cdc-48.1 (via N-terminus) and cdc-48.2 (via N-terminus); the interaction with cdc-48.1 is not required for atx-3 enzymatic activity. Interacts (via C-terminus) with ubxn-5. May interact with ned-8.|||Nucleus|||nucleolus http://togogenome.org/gene/6238:CBG_04316 ^@ http://purl.uniprot.org/uniprot/A8WX82 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Plays an important role in regulating the size of autophagosomes during the formation process. http://togogenome.org/gene/6238:CBG_02671 ^@ http://purl.uniprot.org/uniprot/A8WTS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. http://togogenome.org/gene/6238:CBG_01383 ^@ http://purl.uniprot.org/uniprot/A8WQA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/6238:CBG_09350 ^@ http://purl.uniprot.org/uniprot/A8X9A9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 20 family. http://togogenome.org/gene/6238:CBG_11527 ^@ http://purl.uniprot.org/uniprot/A8XCS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/6238:CBG_04281 ^@ http://purl.uniprot.org/uniprot/A8WX50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_09854 ^@ http://purl.uniprot.org/uniprot/A8X9T6 ^@ Function|||Similarity ^@ Belongs to the phospholipase B-like family.|||Putative phospholipase. http://togogenome.org/gene/6238:CBG_03917 ^@ http://purl.uniprot.org/uniprot/A8WVR2 ^@ Function|||Similarity ^@ Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif (By similarity).|||Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/6238:CBG_08872 ^@ http://purl.uniprot.org/uniprot/A8X7L2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_22316 ^@ http://purl.uniprot.org/uniprot/A8Y221 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_02218 ^@ http://purl.uniprot.org/uniprot/A8WS92 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SKA1 family.|||Component of the ska-1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The ska-1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. In the complex, it mediates the interaction with microtubules.|||Component of the ska1 complex, composed of two copies of ska-1 and a single copy of ska-3. The core complex associates with microtubules and may form dimeric assemblies. Interacts with ska-3 and microtubules.|||kinetochore|||spindle http://togogenome.org/gene/6238:CBG_17652 ^@ http://purl.uniprot.org/uniprot/A8XRL7 ^@ Similarity ^@ Belongs to the threonine aldolase family. http://togogenome.org/gene/6238:CBG_06906 ^@ http://purl.uniprot.org/uniprot/G2J6L0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit.|||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. http://togogenome.org/gene/6238:CBG_20901 ^@ http://purl.uniprot.org/uniprot/A8XYW8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/6238:CBG_07494 ^@ http://purl.uniprot.org/uniprot/G2J6L3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_20942 ^@ http://purl.uniprot.org/uniprot/A8XZ04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sre family.|||Membrane http://togogenome.org/gene/6238:CBG_22775 ^@ http://purl.uniprot.org/uniprot/Q60NC0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Amiloride-sensitive sodium channel subunit required for mechanosensory transduction (touch sensitivity). Negatively regulates the turning step of male mating behavior.|||Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Cell membrane|||The channel is probably composed of at least the mec-2, mec-4, mec-6 and mec-10 subunits. http://togogenome.org/gene/6238:CBG_11102 ^@ http://purl.uniprot.org/uniprot/A8XCE8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/6238:CBG_00301 ^@ http://purl.uniprot.org/uniprot/A8WMN1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/6238:CBG_09152 ^@ http://purl.uniprot.org/uniprot/A8X871 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pescadillo family.|||Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.|||nucleolus|||nucleoplasm http://togogenome.org/gene/6238:CBG_09572 ^@ http://purl.uniprot.org/uniprot/A8X8S5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 25 family. http://togogenome.org/gene/6238:CBG_18237 ^@ http://purl.uniprot.org/uniprot/A8XS78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/6238:CBG_07939 ^@ http://purl.uniprot.org/uniprot/A8X5E8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/6238:CBG_20339 ^@ http://purl.uniprot.org/uniprot/G2J711 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/6238:CBG_01860 ^@ http://purl.uniprot.org/uniprot/A8WRG2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_07426 ^@ http://purl.uniprot.org/uniprot/A8X4S8 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/6238:CBG_04158 ^@ http://purl.uniprot.org/uniprot/A8WWA7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_18251 ^@ http://purl.uniprot.org/uniprot/A8XS90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family.|||Nucleus http://togogenome.org/gene/6238:CBG_18949 ^@ http://purl.uniprot.org/uniprot/A8XUE9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_13704 ^@ http://purl.uniprot.org/uniprot/A8XII4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_19879 ^@ http://purl.uniprot.org/uniprot/A8XWM9 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/6238:CBG_01783 ^@ http://purl.uniprot.org/uniprot/A8WQU5 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/6238:CBG_10810 ^@ http://purl.uniprot.org/uniprot/A8XBU7 ^@ Subcellular Location Annotation ^@ cilium http://togogenome.org/gene/6238:CBG_20034 ^@ http://purl.uniprot.org/uniprot/A8XWZ3 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_03381 ^@ http://purl.uniprot.org/uniprot/A8WUX1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_01666 ^@ http://purl.uniprot.org/uniprot/A8WR46 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family. http://togogenome.org/gene/6238:CBG_03797 ^@ http://purl.uniprot.org/uniprot/A8WWR5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/6238:CBG_15047 ^@ http://purl.uniprot.org/uniprot/A8XLA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/6238:CBG_23373 ^@ http://purl.uniprot.org/uniprot/A8Y427 ^@ Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer. http://togogenome.org/gene/6238:CBG_00624 ^@ http://purl.uniprot.org/uniprot/A8WNF4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_07717 ^@ http://purl.uniprot.org/uniprot/A8X481 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Regulates pharyngeal pumping during feeding. http://togogenome.org/gene/6238:CBG_06987 ^@ http://purl.uniprot.org/uniprot/A8X3Z4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_24374 ^@ http://purl.uniprot.org/uniprot/A8WKK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane http://togogenome.org/gene/6238:CBG_09211 ^@ http://purl.uniprot.org/uniprot/A8X8C2 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/6238:CBG_05682 ^@ http://purl.uniprot.org/uniprot/A8X0F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/6238:CBG_06195 ^@ http://purl.uniprot.org/uniprot/A8X0P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/6238:CBG_03957 ^@ http://purl.uniprot.org/uniprot/A8WVU7 ^@ Function ^@ Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Shown to have roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin (By similarity). http://togogenome.org/gene/6238:CBG_18978 ^@ http://purl.uniprot.org/uniprot/A8XUH4 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6238:CBG_17173 ^@ http://purl.uniprot.org/uniprot/A8XQM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRF family.|||Membrane http://togogenome.org/gene/6238:CBG_09797 ^@ http://purl.uniprot.org/uniprot/A8X9N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/6238:CBG_12902 ^@ http://purl.uniprot.org/uniprot/A8XGM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_17860 ^@ http://purl.uniprot.org/uniprot/A8XRX9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_04341 ^@ http://purl.uniprot.org/uniprot/A8WXB3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_06199 ^@ http://purl.uniprot.org/uniprot/A8X0P1 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/6238:CBG_05834 ^@ http://purl.uniprot.org/uniprot/A8X1I8 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/6238:CBG_03000 ^@ http://purl.uniprot.org/uniprot/A8WT11 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the F-actin-capping protein beta subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit.|||cytoskeleton http://togogenome.org/gene/6238:CBG_06439 ^@ http://purl.uniprot.org/uniprot/A8X282 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/6238:CBG_16511 ^@ http://purl.uniprot.org/uniprot/A8XPD4 ^@ Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.|||Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. http://togogenome.org/gene/6238:CBG_06370 ^@ http://purl.uniprot.org/uniprot/A8X231 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/6238:CBG_21511 ^@ http://purl.uniprot.org/uniprot/A8Y0A3 ^@ Subcellular Location Annotation ^@ Lysosome membrane http://togogenome.org/gene/6238:CBG_20808 ^@ http://purl.uniprot.org/uniprot/A8XYN8 ^@ Similarity ^@ Belongs to the TTC38 family. http://togogenome.org/gene/6238:CBG_10571 ^@ http://purl.uniprot.org/uniprot/A8XBC2 ^@ Similarity ^@ Belongs to the glycosyltransferase 92 family. http://togogenome.org/gene/6238:CBG_05838 ^@ http://purl.uniprot.org/uniprot/G2J6F9 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_08224 ^@ http://purl.uniprot.org/uniprot/A8X633 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenomatous polyposis coli (APC) family.|||Cytoplasm|||Has a role in endoderm cell specification and pharyngeal development. Required for the migration of epithelial cells, organization of the anterior seam cells and ceh-13 expression during embryo morphogenesis. Prevents hyperactivation of the Wnt signaling pathway during endoderm development, probably by preventing hmp-2 nuclear translocation. During larval development, apr-1 is required for expression of lin-39 in P3-8.p. Shown to negatively regulate Wnt signaling in vulval precursor cells. Has a role in cell division by establishing the polarity of the mother cell which forms the asymmetries of the daughter nuclei. Thought to regulate export of wrm-1 from the nucleus possibly as part of a complex involving pry-1.|||Interacts (via N-terminus) with bar-1 and hmp-2; the interaction with hmp-2 is relatively weak. Interacts (via C-terminus) with pry-1 (via N-terminus). Probably associates with bar-1, gsk-3, pry-1 in a complex (By similarity).|||Nucleus|||adherens junction http://togogenome.org/gene/6238:CBG_11300 ^@ http://purl.uniprot.org/uniprot/A8XDC3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_18863 ^@ http://purl.uniprot.org/uniprot/A8XU83 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic AdoMetDC family.|||Binds 1 pyruvoyl group covalently per subunit. http://togogenome.org/gene/6238:CBG_03214 ^@ http://purl.uniprot.org/uniprot/A8WSJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/6238:CBG_08569 ^@ http://purl.uniprot.org/uniprot/A8X739 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL28 family. http://togogenome.org/gene/6238:CBG_19018 ^@ http://purl.uniprot.org/uniprot/A8XUK8 ^@ Subcellular Location Annotation ^@ Endosome http://togogenome.org/gene/6238:CBG_16307 ^@ http://purl.uniprot.org/uniprot/A8XNQ3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_09957 ^@ http://purl.uniprot.org/uniprot/A8XA16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/6238:CBG_23229 ^@ http://purl.uniprot.org/uniprot/A8Y4E7 ^@ Similarity ^@ Belongs to the tubulin--tyrosine ligase family. http://togogenome.org/gene/6238:CBG_15283 ^@ http://purl.uniprot.org/uniprot/A8XLH4 ^@ Subcellular Location Annotation ^@ perinuclear region http://togogenome.org/gene/6238:CBG_18688 ^@ http://purl.uniprot.org/uniprot/A8XTW8 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/6238:CBG_12512 ^@ http://purl.uniprot.org/uniprot/A8XFY1 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/6238:CBG_00973 ^@ http://purl.uniprot.org/uniprot/Q626I0 ^@ Domain|||Function|||Similarity ^@ Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.|||In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.|||In the N-terminal section; belongs to the MoaB/Mog family.|||The molybdenum cofactor biosynthesis protein-like region may not be functional. http://togogenome.org/gene/6238:CBG_07358 ^@ http://purl.uniprot.org/uniprot/A8X4Y2 ^@ Similarity ^@ Belongs to the liprin family. Liprin-beta subfamily. http://togogenome.org/gene/6238:CBG_05467 ^@ http://purl.uniprot.org/uniprot/A8WZY2 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/6238:CBG_19184 ^@ http://purl.uniprot.org/uniprot/A8XV09 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/6238:CBG_02605 ^@ http://purl.uniprot.org/uniprot/A8WTY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_01557 ^@ http://purl.uniprot.org/uniprot/A8WRD5 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/6238:CBG_16384 ^@ http://purl.uniprot.org/uniprot/A8XNJ8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/6238:CBG_09554 ^@ http://purl.uniprot.org/uniprot/A8X8U0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_07018 ^@ http://purl.uniprot.org/uniprot/A8X3W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/6238:CBG_02731 ^@ http://purl.uniprot.org/uniprot/A1XDB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFP11/STIP family.|||May be involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/6238:CBG_05258 ^@ http://purl.uniprot.org/uniprot/A8WZH3 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/6238:CBG_18111 ^@ http://purl.uniprot.org/uniprot/A8XT19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DUOXA family.|||Membrane http://togogenome.org/gene/6238:CBG_21102 ^@ http://purl.uniprot.org/uniprot/A8XZH1 ^@ Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. http://togogenome.org/gene/6238:CBG_21665 ^@ http://purl.uniprot.org/uniprot/A8Y0T1 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srd family. http://togogenome.org/gene/6238:CBG_07591 ^@ http://purl.uniprot.org/uniprot/A8X4H6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. http://togogenome.org/gene/6238:CBG_22776 ^@ http://purl.uniprot.org/uniprot/A8Y2V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_10449 ^@ http://purl.uniprot.org/uniprot/A8XB88 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/6238:CBG_18189 ^@ http://purl.uniprot.org/uniprot/A8XT81 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB8 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively. Directly interacts with POLR2A (By similarity).|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity).|||Nucleus http://togogenome.org/gene/6238:CBG_10442 ^@ http://purl.uniprot.org/uniprot/E3CU18 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_08664 ^@ http://purl.uniprot.org/uniprot/A8X6V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Late endosome membrane|||Membrane http://togogenome.org/gene/6238:CBG_12933 ^@ http://purl.uniprot.org/uniprot/A8XGQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HIT family.|||Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.|||Nucleus http://togogenome.org/gene/6238:CBG_12564 ^@ http://purl.uniprot.org/uniprot/A8XG20 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. http://togogenome.org/gene/6238:CBG_01610 ^@ http://purl.uniprot.org/uniprot/Q624D2 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||In contrast to other ephrins, does not seem to signal through the vab-1 receptor.|||May undergo proteolysis by metalloprotease sup-17 to give rise to a soluble form.|||Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, involved in ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting together with mab-20 and allows the formation of distinct sensory rays. Probably acts as a ligand for lad-2 to regulate axon guidance of several neurons including SDQL, SDQR, SMD and PLN neurons during neurogenesis. http://togogenome.org/gene/6238:CBG_03634 ^@ http://purl.uniprot.org/uniprot/A8WVH5 ^@ Similarity ^@ Belongs to the RRN3 family. http://togogenome.org/gene/6238:CBG_23461 ^@ http://purl.uniprot.org/uniprot/A8Y3V1 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_20774 ^@ http://purl.uniprot.org/uniprot/A8XYK9 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/6238:CBG_10702 ^@ http://purl.uniprot.org/uniprot/A8XBL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/6238:CBG_07767 ^@ http://purl.uniprot.org/uniprot/A8X447 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/6238:CBG_01321 ^@ http://purl.uniprot.org/uniprot/A8WQ49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_06104 ^@ http://purl.uniprot.org/uniprot/A8X0W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/6238:CBG_05177 ^@ http://purl.uniprot.org/uniprot/A8WZB2 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/6238:CBG_08707 ^@ http://purl.uniprot.org/uniprot/A8X775 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Component of a MAP kinase pathway that functions presynaptically to regulate synaptic architecture and presynaptic differentiation. Phosphorylates and activates mkk-4 (By similarity).|||Synapse|||Ubiquitinated by rpm-1. Negatively regulated by ubiquitination by fsn-1 bound rpm-1, followed by degradation (By similarity). http://togogenome.org/gene/6238:CBG_13916 ^@ http://purl.uniprot.org/uniprot/A8XJ16 ^@ Similarity ^@ Belongs to the GDNFR family. http://togogenome.org/gene/6238:CBG_00320 ^@ http://purl.uniprot.org/uniprot/A8WMP8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/6238:CBG_02789 ^@ http://purl.uniprot.org/uniprot/A8WTI2 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_03331 ^@ http://purl.uniprot.org/uniprot/A8WUT0 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/6238:CBG_23916 ^@ http://purl.uniprot.org/uniprot/A8WJK7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_10799 ^@ http://purl.uniprot.org/uniprot/A8XBT9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_10952 ^@ http://purl.uniprot.org/uniprot/A8XBX8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6238:CBG_13456 ^@ http://purl.uniprot.org/uniprot/A8XHQ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_07909 ^@ http://purl.uniprot.org/uniprot/A8X562 ^@ Similarity ^@ Belongs to the helicase family. SKI2 subfamily. http://togogenome.org/gene/6238:CBG_08171 ^@ http://purl.uniprot.org/uniprot/A8X5Z5 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/6238:CBG_10789 ^@ http://purl.uniprot.org/uniprot/A8XBT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/6238:CBG_19324 ^@ http://purl.uniprot.org/uniprot/A8XVC9 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srd family. http://togogenome.org/gene/6238:CBG_05818 ^@ http://purl.uniprot.org/uniprot/A8X1K0 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_05940 ^@ http://purl.uniprot.org/uniprot/A8X1A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Membrane http://togogenome.org/gene/6238:CBG_09591 ^@ http://purl.uniprot.org/uniprot/A8X8Q6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SLU7 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/6238:CBG_13388 ^@ http://purl.uniprot.org/uniprot/A8XHV8 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/6238:CBG_12644 ^@ http://purl.uniprot.org/uniprot/A8XG86 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/6238:CBG_12566 ^@ http://purl.uniprot.org/uniprot/A8XG22 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/6238:CBG_07351 ^@ http://purl.uniprot.org/uniprot/A8X4Y7 ^@ Similarity ^@ Belongs to the UPF0585 family. http://togogenome.org/gene/6238:CBG_22831 ^@ http://purl.uniprot.org/uniprot/A8Y357 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_07732 ^@ http://purl.uniprot.org/uniprot/A8X474 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/6238:CBG_18262 ^@ http://purl.uniprot.org/uniprot/A8XSA1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBR family. Parkin subfamily.|||Forms an E3 ubiquitin ligase complex.|||Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.|||Mitochondrion|||cytosol http://togogenome.org/gene/6238:CBG_14138 ^@ http://purl.uniprot.org/uniprot/A8XJE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase inhibitor family.|||Mitochondrion|||Thought to be a regulatory component of the ATP-synthesizing complex in the mitochondria. http://togogenome.org/gene/6238:CBG_05041 ^@ http://purl.uniprot.org/uniprot/A8WZ17 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_20715 ^@ http://purl.uniprot.org/uniprot/A8XYG1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_01722 ^@ http://purl.uniprot.org/uniprot/Q623U2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the JMJD6 family.|||Binds 1 Fe(2+) ion per subunit.|||Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase.|||Interacts with ced-5 and ced-12.|||Nucleus http://togogenome.org/gene/6238:CBG_07124 ^@ http://purl.uniprot.org/uniprot/A8X3N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/6238:CBG_02448 ^@ http://purl.uniprot.org/uniprot/A8WUA8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 25 family. http://togogenome.org/gene/6238:CBG_00986 ^@ http://purl.uniprot.org/uniprot/A8WP61 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/6238:CBG_01654 ^@ http://purl.uniprot.org/uniprot/A8WR57 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_11441 ^@ http://purl.uniprot.org/uniprot/A8XD05 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/6238:CBG_06883 ^@ http://purl.uniprot.org/uniprot/A8X3A1 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/6238:CBG_23242 ^@ http://purl.uniprot.org/uniprot/A8Y4D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/6238:CBG_23360 ^@ http://purl.uniprot.org/uniprot/A8Y440 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||Nucleus http://togogenome.org/gene/6238:CBG_08992 ^@ http://purl.uniprot.org/uniprot/Q61LC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Golgi apparatus membrane|||Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi (By similarity). http://togogenome.org/gene/6238:CBG_18329 ^@ http://purl.uniprot.org/uniprot/A8XSG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/6238:CBG_03293 ^@ http://purl.uniprot.org/uniprot/A8WSD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-Y family.|||Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.|||Nucleus http://togogenome.org/gene/6238:CBG_19536 ^@ http://purl.uniprot.org/uniprot/A8XVU6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_02395 ^@ http://purl.uniprot.org/uniprot/A8WUF2 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/6238:CBG_00798 ^@ http://purl.uniprot.org/uniprot/A8WNU9 ^@ Similarity ^@ Belongs to the plant self-incompatibility (S1) protein family. http://togogenome.org/gene/6238:CBG_18986 ^@ http://purl.uniprot.org/uniprot/Q60WU2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synaptobrevin family.|||Cell membrane|||Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function (By similarity).|||Part of the SNARE core complex containing CBG09569/SNAP25, snb-1/VAMP2 and CBG03570/STX1A. This complex binds to cpx-1/CPLX1 (By similarity).|||synaptic vesicle membrane|||synaptosome http://togogenome.org/gene/6238:CBG_15718 ^@ http://purl.uniprot.org/uniprot/A8XML8 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily. http://togogenome.org/gene/6238:CBG_17724 ^@ http://purl.uniprot.org/uniprot/Q60ZN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sidekick family.|||Cell adhesion protein.|||Membrane http://togogenome.org/gene/6238:CBG_13068 ^@ http://purl.uniprot.org/uniprot/A8XH03 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the pre-60S ribosomal particle.|||Belongs to the universal ribosomal protein uL10 family.|||Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.|||Cytoplasm|||nucleolus http://togogenome.org/gene/6238:CBG_02883 ^@ http://purl.uniprot.org/uniprot/A8WTA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Nucleus http://togogenome.org/gene/6238:CBG_12641 ^@ http://purl.uniprot.org/uniprot/Q61D44 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Active in presence of diverse metals including Fe(2+), Zn(2+), Mn(2+) (By similarity). Binds two metal cations in two adjacent alpha and beta metal-binding pockets (By similarity).|||Belongs to the lariat debranching enzyme family.|||Binds 2 divalent metal cations per subunit.|||Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover.|||Nucleus http://togogenome.org/gene/6238:CBG_11588 ^@ http://purl.uniprot.org/uniprot/A8XDK4 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Fibrillarin family. http://togogenome.org/gene/6238:CBG_02853 ^@ http://purl.uniprot.org/uniprot/A8WTD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 7 family.|||Nucleus http://togogenome.org/gene/6238:CBG_19058 ^@ http://purl.uniprot.org/uniprot/A8XUP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_07849 ^@ http://purl.uniprot.org/uniprot/A8X596 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/6238:CBG_01576 ^@ http://purl.uniprot.org/uniprot/A8WRC1 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/6238:CBG_02772 ^@ http://purl.uniprot.org/uniprot/A8WTJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP2 family.|||Membrane http://togogenome.org/gene/6238:CBG_18107 ^@ http://purl.uniprot.org/uniprot/A8XT18 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/6238:CBG_12032 ^@ http://purl.uniprot.org/uniprot/A8XEE3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_10003 ^@ http://purl.uniprot.org/uniprot/A8XA54 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/6238:CBG_08738 ^@ http://purl.uniprot.org/uniprot/A8X798 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/6238:CBG_15175 ^@ http://purl.uniprot.org/uniprot/A8XLR9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with an ATP-specific beta subunit, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with a GTP-specific beta subunit forms a GDP-forming succinyl-CoA synthetase (G-SCS).|||Mitochondrion|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. http://togogenome.org/gene/6238:CBG_05561 ^@ http://purl.uniprot.org/uniprot/A8X056 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/6238:CBG_07470 ^@ http://purl.uniprot.org/uniprot/A8X4Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Chromosome|||Nucleus http://togogenome.org/gene/6238:CBG_16690 ^@ http://purl.uniprot.org/uniprot/A8XPM1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_11305 ^@ http://purl.uniprot.org/uniprot/A8XDB8 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/6238:CBG_12804 ^@ http://purl.uniprot.org/uniprot/Q61CQ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SPCS1 family.|||Component of the signal peptidase complex (SPC) composed of a catalytic subunit sec-11 and three accessory subunits spcs-1, spcs-2 and spcs-3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids.|||Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Dispensable for SPC enzymatic activity (By similarity).|||Endoplasmic reticulum membrane http://togogenome.org/gene/6238:CBG_02160 ^@ http://purl.uniprot.org/uniprot/A8WS31 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/6238:CBG_21042 ^@ http://purl.uniprot.org/uniprot/A8XZB4 ^@ Similarity ^@ Belongs to the vacuolar ATPase subunit S1 family. http://togogenome.org/gene/6238:CBG_06230 ^@ http://purl.uniprot.org/uniprot/A8X0L1 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_14829 ^@ http://purl.uniprot.org/uniprot/P19208 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ AMPylated by fic-1.|||Belongs to the heat shock protein 70 family.|||Endoplasmic reticulum lumen|||Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. http://togogenome.org/gene/6238:CBG_06064 ^@ http://purl.uniprot.org/uniprot/A8X0Z6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_19478 ^@ http://purl.uniprot.org/uniprot/A8XVN1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_14696 ^@ http://purl.uniprot.org/uniprot/G2J6U9 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/6238:CBG_06422 ^@ http://purl.uniprot.org/uniprot/A8X270 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_07714 ^@ http://purl.uniprot.org/uniprot/Q61P40 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the copper type II ascorbate-dependent monooxygenase family.|||Binds 2 copper ions per subunit.|||Catalyzes the hydroxylation of tyramine into octopamine, a neurotransmitter involved in pharyngeal pumping and egg laying.|||synaptic vesicle http://togogenome.org/gene/6238:CBG_00337 ^@ http://purl.uniprot.org/uniprot/A8WMV1 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_10551 ^@ http://purl.uniprot.org/uniprot/A8XBD5 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/6238:CBG_18374 ^@ http://purl.uniprot.org/uniprot/A8XSJ8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/6238:CBG_20951 ^@ http://purl.uniprot.org/uniprot/A8XZ10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sre family.|||Membrane http://togogenome.org/gene/6238:CBG_23151 ^@ http://purl.uniprot.org/uniprot/A8Y4K9 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_07989 ^@ http://purl.uniprot.org/uniprot/Q5WNI9 ^@ Function|||Similarity ^@ Belongs to the dopey family.|||Essential for cell patterning during gastrulation. May be involved in protein traffic between late Golgi and early endosomes (By similarity). http://togogenome.org/gene/6238:CBG_19682 ^@ http://purl.uniprot.org/uniprot/A8XW67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/6238:CBG_22170 ^@ http://purl.uniprot.org/uniprot/A8Y1Q2 ^@ Similarity ^@ Belongs to the HMG-CoA lyase family. http://togogenome.org/gene/6238:CBG_12722 ^@ http://purl.uniprot.org/uniprot/A8XGF2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_13458 ^@ http://purl.uniprot.org/uniprot/A8XHQ1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acireductone dioxygenase (ARD) family.|||Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.|||Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.|||Cytoplasm|||Nucleus|||This enzyme lacks one or more conserved metal-binding sites. It may be non-functional. http://togogenome.org/gene/6238:CBG_04534 ^@ http://purl.uniprot.org/uniprot/A8WXN3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/6238:CBG_11577 ^@ http://purl.uniprot.org/uniprot/A8XDJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/6238:CBG_16758 ^@ http://purl.uniprot.org/uniprot/A8XPR6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_04323 ^@ http://purl.uniprot.org/uniprot/A8WX91 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_01629 ^@ http://purl.uniprot.org/uniprot/E3CTV9 ^@ Similarity ^@ Belongs to the peptidase M24 family. http://togogenome.org/gene/6238:CBG_19800 ^@ http://purl.uniprot.org/uniprot/A8XWA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/6238:CBG_08694 ^@ http://purl.uniprot.org/uniprot/A8X6S6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_17708 ^@ http://purl.uniprot.org/uniprot/A8XRH0 ^@ Similarity ^@ Belongs to the learning-associated protein family. http://togogenome.org/gene/6238:CBG_07163 ^@ http://purl.uniprot.org/uniprot/A8X3K5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_20269 ^@ http://purl.uniprot.org/uniprot/A8XXD3 ^@ Similarity ^@ Belongs to the thymidylate synthase family. http://togogenome.org/gene/6238:CBG_04262 ^@ http://purl.uniprot.org/uniprot/A8WX30 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6238:CBG_03105 ^@ http://purl.uniprot.org/uniprot/A8WSS4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_00076 ^@ http://purl.uniprot.org/uniprot/A8WM92 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/6238:CBG_15988 ^@ http://purl.uniprot.org/uniprot/A8XNC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SID1 family.|||Membrane http://togogenome.org/gene/6238:CBG_06212 ^@ http://purl.uniprot.org/uniprot/Q61SE7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrion-specific ribosomal protein mL51 family.|||Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins (By similarity).|||Mitochondrion http://togogenome.org/gene/6238:CBG_00501 ^@ http://purl.uniprot.org/uniprot/A8WMT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/6238:CBG_02553 ^@ http://purl.uniprot.org/uniprot/A8WU21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/6238:CBG_16194 ^@ http://purl.uniprot.org/uniprot/A8XNX0 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/6238:CBG_20586 ^@ http://purl.uniprot.org/uniprot/A8XY53 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/6238:CBG_10310 ^@ http://purl.uniprot.org/uniprot/A8XAM6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_12990 ^@ http://purl.uniprot.org/uniprot/A8XGU5 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_06915 ^@ http://purl.uniprot.org/uniprot/A8X3C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/6238:CBG_13485 ^@ http://purl.uniprot.org/uniprot/A8XHM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS18 family.|||Membrane http://togogenome.org/gene/6238:CBG_06617 ^@ http://purl.uniprot.org/uniprot/Q61RF0 ^@ Similarity ^@ Belongs to the RRP15 family. http://togogenome.org/gene/6238:CBG_10559 ^@ http://purl.uniprot.org/uniprot/A8XBD0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the myo-inositol oxygenase family.|||Binds 2 iron ions per subunit.|||Cytoplasm http://togogenome.org/gene/6238:CBG_17972 ^@ http://purl.uniprot.org/uniprot/A8XSQ1 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_11073 ^@ http://purl.uniprot.org/uniprot/A8XCC5 ^@ Function|||Similarity ^@ Catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a 2 step process.|||In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.|||In the N-terminal section; belongs to the glycosyltransferase 20 family. http://togogenome.org/gene/6238:CBG_07090 ^@ http://purl.uniprot.org/uniprot/A8X3Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG2 family.|||Cytoplasmic vesicle|||Endoplasmic reticulum membrane|||Nucleus envelope|||Nucleus inner membrane|||Nucleus outer membrane|||Vesicle http://togogenome.org/gene/6238:CBG_15506 ^@ http://purl.uniprot.org/uniprot/A8XM67 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_18244 ^@ http://purl.uniprot.org/uniprot/A8XS84 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_09729 ^@ http://purl.uniprot.org/uniprot/A8X8E5 ^@ Similarity ^@ Belongs to the FAD-binding oxidoreductase/transferase type 4 family.|||Belongs to the PIH1 family. http://togogenome.org/gene/6238:CBG_09979 ^@ http://purl.uniprot.org/uniprot/A8XA31 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/6238:CBG_14244 ^@ http://purl.uniprot.org/uniprot/A8XJL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/6238:CBG_05465 ^@ http://purl.uniprot.org/uniprot/A8WZY0 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_10118 ^@ http://purl.uniprot.org/uniprot/A8XAF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/6238:CBG_20956 ^@ http://purl.uniprot.org/uniprot/A8XZ15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sre family.|||Membrane http://togogenome.org/gene/6238:CBG_05145 ^@ http://purl.uniprot.org/uniprot/A8WZ62 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/6238:CBG_05372 ^@ http://purl.uniprot.org/uniprot/A8WZQ2 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/6238:CBG_15355 ^@ http://purl.uniprot.org/uniprot/A8XM09 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_19736 ^@ http://purl.uniprot.org/uniprot/A8XWF8 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/6238:CBG_03798 ^@ http://purl.uniprot.org/uniprot/Q61XX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ribonuclease III family.|||Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA (By similarity).|||Nucleus http://togogenome.org/gene/6238:CBG_21221 ^@ http://purl.uniprot.org/uniprot/A8XZK3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/6238:CBG_20451 ^@ http://purl.uniprot.org/uniprot/A8XXT3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/6238:CBG_06237 ^@ http://purl.uniprot.org/uniprot/A8X0K4 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/6238:CBG_20979 ^@ http://purl.uniprot.org/uniprot/A8XZ32 ^@ Caution|||Similarity ^@ Belongs to the nematode receptor-like protein srg family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_11192 ^@ http://purl.uniprot.org/uniprot/A8XCN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/6238:CBG_15213 ^@ http://purl.uniprot.org/uniprot/A8XLN4 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Homodimer. http://togogenome.org/gene/6238:CBG_02453 ^@ http://purl.uniprot.org/uniprot/A8WUA5 ^@ Similarity ^@ Belongs to the TPA1 family. http://togogenome.org/gene/6238:CBG_12061 ^@ http://purl.uniprot.org/uniprot/A8XEG6 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.|||Heterodimer of a catalytic heavy chain and a regulatory light chain. http://togogenome.org/gene/6238:CBG_02213 ^@ http://purl.uniprot.org/uniprot/A8WS97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM256 family.|||Membrane http://togogenome.org/gene/6238:CBG_06387 ^@ http://purl.uniprot.org/uniprot/A8X243 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_05165 ^@ http://purl.uniprot.org/uniprot/A8WZA1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/6238:CBG_02788 ^@ http://purl.uniprot.org/uniprot/A8WTI3 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_13684 ^@ http://purl.uniprot.org/uniprot/A8XIH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ING family.|||Nucleus http://togogenome.org/gene/6238:CBG_04501 ^@ http://purl.uniprot.org/uniprot/A8WXR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/6238:CBG_23341 ^@ http://purl.uniprot.org/uniprot/A8Y455 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_03393 ^@ http://purl.uniprot.org/uniprot/A8WUY3 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_05886 ^@ http://purl.uniprot.org/uniprot/G2J6F9 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_09049 ^@ http://purl.uniprot.org/uniprot/A8X7X6 ^@ Similarity ^@ Belongs to the BCL7 family. http://togogenome.org/gene/6238:CBG_09180 ^@ http://purl.uniprot.org/uniprot/A8X890 ^@ Similarity ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. http://togogenome.org/gene/6238:CBG_12444 ^@ http://purl.uniprot.org/uniprot/A8XFG1 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/6238:CBG_21851 ^@ http://purl.uniprot.org/uniprot/A8Y0Z3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_00631 ^@ http://purl.uniprot.org/uniprot/A8WNE8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/6238:CBG_08327 ^@ http://purl.uniprot.org/uniprot/A8X6B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF2 family.|||Nucleus http://togogenome.org/gene/6238:CBG_19695 ^@ http://purl.uniprot.org/uniprot/Q60V51 ^@ Function|||Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.|||Required for branched chain fatty acid synthesis. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. Very long-chain fatty acids (VLCFAs) serve as precursors for ceramide and sphingolipids. May also be required for sterol hormone production (By similarity). http://togogenome.org/gene/6238:CBG_04219 ^@ http://purl.uniprot.org/uniprot/A8WWG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAP-alpha family.|||Endoplasmic reticulum membrane|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. http://togogenome.org/gene/6238:CBG_17402 ^@ http://purl.uniprot.org/uniprot/A8XQZ5 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_16281 ^@ http://purl.uniprot.org/uniprot/A8XNR4 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/6238:CBG_04320 ^@ http://purl.uniprot.org/uniprot/A8WX87 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/6238:CBG_19691 ^@ http://purl.uniprot.org/uniprot/A8XW76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the REI1 family.|||Cytoplasm http://togogenome.org/gene/6238:CBG_20369 ^@ http://purl.uniprot.org/uniprot/A8XXM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.|||Cytoplasm|||Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.|||Monomer. http://togogenome.org/gene/6238:CBG_23066 ^@ http://purl.uniprot.org/uniprot/A8Y4S6 ^@ Function|||Subunit ^@ EF-1 is composed of four subunits: alpha, beta, delta, and gamma.|||Probably plays a role in anchoring the complex to other cellular components. http://togogenome.org/gene/6238:CBG_21174 ^@ http://purl.uniprot.org/uniprot/A8XZB8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/6238:CBG_16491 ^@ http://purl.uniprot.org/uniprot/G2J6X0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/6238:CBG_05511 ^@ http://purl.uniprot.org/uniprot/A8X020 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the QNG1 protein family.|||Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.|||Cytoplasm http://togogenome.org/gene/6238:CBG_18006 ^@ http://purl.uniprot.org/uniprot/A8XST2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/6238:CBG_12713 ^@ http://purl.uniprot.org/uniprot/A8XGE4 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/6238:CBG_03613 ^@ http://purl.uniprot.org/uniprot/A8WVG3 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/6238:CBG_03041 ^@ http://purl.uniprot.org/uniprot/A8WSX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/6238:CBG_02934 ^@ http://purl.uniprot.org/uniprot/Q61ZW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LIMR family.|||Cell membrane|||May associate with G-protein coupled receptors and regulate downstream signaling pathways. http://togogenome.org/gene/6238:CBG_04604 ^@ http://purl.uniprot.org/uniprot/A8WY14 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_06270 ^@ http://purl.uniprot.org/uniprot/A8X0H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/6238:CBG_09491 ^@ http://purl.uniprot.org/uniprot/A8X8Z9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/6238:CBG_21922 ^@ http://purl.uniprot.org/uniprot/Q60Q85 ^@ Cofactor|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Binds 2 Zn(2+) ions per subunit.|||Carboxylation allows a single lysine to coordinate two zinc ions.|||Homotetramer.|||Nucleus http://togogenome.org/gene/6238:CBG_19952 ^@ http://purl.uniprot.org/uniprot/A8XWS9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC4 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_00558 ^@ http://purl.uniprot.org/uniprot/A8WNL3 ^@ Similarity ^@ Belongs to the KRI1 family. http://togogenome.org/gene/6238:CBG_13547 ^@ http://purl.uniprot.org/uniprot/A8XI57 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/6238:CBG_11138 ^@ http://purl.uniprot.org/uniprot/A8XCJ3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_06052 ^@ http://purl.uniprot.org/uniprot/A8X108 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_04194 ^@ http://purl.uniprot.org/uniprot/A8WWE1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_17273 ^@ http://purl.uniprot.org/uniprot/A8XQQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/6238:CBG_20783 ^@ http://purl.uniprot.org/uniprot/A8XYL7 ^@ Similarity ^@ Belongs to the SUA5 family. http://togogenome.org/gene/6238:CBG_20288 ^@ http://purl.uniprot.org/uniprot/A8XXG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Membrane http://togogenome.org/gene/6238:CBG_13304 ^@ http://purl.uniprot.org/uniprot/A8XHI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF12 family.|||Nucleus http://togogenome.org/gene/6238:CBG_20987 ^@ http://purl.uniprot.org/uniprot/A8XZ40 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srg family. http://togogenome.org/gene/6238:CBG_02247 ^@ http://purl.uniprot.org/uniprot/A8WS68 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/6238:CBG_13470 ^@ http://purl.uniprot.org/uniprot/Q17295 ^@ Function|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Accumulation defines the body wall muscle cell fate during embryogenesis.|||Body wall muscle cells; in clonal muscle precursors, in a set of early embryonic blastomeres (the ms-granddaughters), and in six glial-like cells called GLRS.|||Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/6238:CBG_06731 ^@ http://purl.uniprot.org/uniprot/A8X2Y9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_06863 ^@ http://purl.uniprot.org/uniprot/A8X386 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/6238:CBG_23535 ^@ http://purl.uniprot.org/uniprot/A8Y3P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_01115 ^@ http://purl.uniprot.org/uniprot/A8WPL2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_06668 ^@ http://purl.uniprot.org/uniprot/A8X2T5 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/6238:CBG_04603 ^@ http://purl.uniprot.org/uniprot/A8WY13 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_03449 ^@ http://purl.uniprot.org/uniprot/A8WV33 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_01476 ^@ http://purl.uniprot.org/uniprot/A8WQL4 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/6238:CBG_13447 ^@ http://purl.uniprot.org/uniprot/A8XHR0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_19844 ^@ http://purl.uniprot.org/uniprot/E3CU74 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/6238:CBG_00805 ^@ http://purl.uniprot.org/uniprot/A8WNV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.|||May be involved in iron transport and iron homeostasis.|||Membrane http://togogenome.org/gene/6238:CBG_10871 ^@ http://purl.uniprot.org/uniprot/A8XC64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/6238:CBG_01600 ^@ http://purl.uniprot.org/uniprot/A8WRA1 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_05757 ^@ http://purl.uniprot.org/uniprot/A8X1P9 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srg family. http://togogenome.org/gene/6238:CBG_13737 ^@ http://purl.uniprot.org/uniprot/A8XIK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polycystin family.|||Membrane http://togogenome.org/gene/6238:CBG_23369 ^@ http://purl.uniprot.org/uniprot/A8Y431 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/6238:CBG_04592 ^@ http://purl.uniprot.org/uniprot/A8WY05 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/6238:CBG_06805 ^@ http://purl.uniprot.org/uniprot/A8X344 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/6238:CBG_13358 ^@ http://purl.uniprot.org/uniprot/A8XHY6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_03927 ^@ http://purl.uniprot.org/uniprot/A8WVS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM53 family.|||Membrane|||Nucleus outer membrane http://togogenome.org/gene/6238:CBG_13109 ^@ http://purl.uniprot.org/uniprot/A8XH38 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/6238:CBG_00595 ^@ http://purl.uniprot.org/uniprot/A8WNH9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.|||Belongs to the arsA ATPase family.|||Cytoplasm|||Endoplasmic reticulum|||Homodimer. http://togogenome.org/gene/6238:CBG_10240 ^@ http://purl.uniprot.org/uniprot/A8XAS4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6238:CBG_21964 ^@ http://purl.uniprot.org/uniprot/A8Y143 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/6238:CBG_12816 ^@ http://purl.uniprot.org/uniprot/A8XFP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAM family.|||Nucleus http://togogenome.org/gene/6238:CBG_07031 ^@ http://purl.uniprot.org/uniprot/A8X3V3 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/6238:CBG_04942 ^@ http://purl.uniprot.org/uniprot/A8WYV1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_10898 ^@ http://purl.uniprot.org/uniprot/A8XC81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG2 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Preautophagosomal structure membrane http://togogenome.org/gene/6238:CBG_13694 ^@ http://purl.uniprot.org/uniprot/A8XIH8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_09245 ^@ http://purl.uniprot.org/uniprot/A8X9J4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_05597 ^@ http://purl.uniprot.org/uniprot/A8X086 ^@ Similarity ^@ Belongs to the MAPRE family. http://togogenome.org/gene/6238:CBG_05673 ^@ http://purl.uniprot.org/uniprot/A8X0E8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_24164 ^@ http://purl.uniprot.org/uniprot/A8WK42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HEXIM family.|||Nucleus http://togogenome.org/gene/6238:CBG_04561 ^@ http://purl.uniprot.org/uniprot/A8WXX7 ^@ Similarity ^@ Belongs to the FAM50 family. http://togogenome.org/gene/6238:CBG_15746 ^@ http://purl.uniprot.org/uniprot/A8XMP5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC3 family.|||Component of the Arp2/3 complex.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/6238:CBG_12101 ^@ http://purl.uniprot.org/uniprot/A8XER5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||Structural component of the gap junctions.|||gap junction http://togogenome.org/gene/6238:CBG_03682 ^@ http://purl.uniprot.org/uniprot/A8WVL0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_11884 ^@ http://purl.uniprot.org/uniprot/A8XE83 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/6238:CBG_07116 ^@ http://purl.uniprot.org/uniprot/A8X3N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/6238:CBG_09838 ^@ http://purl.uniprot.org/uniprot/A8X9S0 ^@ Similarity ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family. http://togogenome.org/gene/6238:CBG_12053 ^@ http://purl.uniprot.org/uniprot/A8XEF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||Structural component of the gap junctions.|||gap junction http://togogenome.org/gene/6238:CBG_05842 ^@ http://purl.uniprot.org/uniprot/G2J6C3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_23241 ^@ http://purl.uniprot.org/uniprot/A8Y4D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/6238:CBG_17717 ^@ http://purl.uniprot.org/uniprot/A8XRG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZW10 family.|||kinetochore http://togogenome.org/gene/6238:CBG_17289 ^@ http://purl.uniprot.org/uniprot/A8XQR9 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/6238:CBG_06352 ^@ http://purl.uniprot.org/uniprot/A8X215 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/6238:CBG_12918 ^@ http://purl.uniprot.org/uniprot/A8XGN8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_23343 ^@ http://purl.uniprot.org/uniprot/A8Y454 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6238:CBG_24344 ^@ http://purl.uniprot.org/uniprot/A8WKI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Membrane http://togogenome.org/gene/6238:CBG_01391 ^@ http://purl.uniprot.org/uniprot/A8WQB0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_19475 ^@ http://purl.uniprot.org/uniprot/A8XVM8 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/6238:CBG_06233 ^@ http://purl.uniprot.org/uniprot/A8X0K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRBN family.|||Nucleus http://togogenome.org/gene/6238:CBG_06223 ^@ http://purl.uniprot.org/uniprot/A8X0L8 ^@ Similarity ^@ Belongs to the SF3A2 family. http://togogenome.org/gene/6238:CBG_12563 ^@ http://purl.uniprot.org/uniprot/Q61DA8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.|||Mitochondrion http://togogenome.org/gene/6238:CBG_05595 ^@ http://purl.uniprot.org/uniprot/A8X084 ^@ Similarity ^@ Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily. http://togogenome.org/gene/6238:CBG_21443 ^@ http://purl.uniprot.org/uniprot/A8Y024 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_04608 ^@ http://purl.uniprot.org/uniprot/A8WY18 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/6238:CBG_21050 ^@ http://purl.uniprot.org/uniprot/A8XZA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/6238:CBG_06252 ^@ http://purl.uniprot.org/uniprot/Q1M2W4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/6238:CBG_00741 ^@ http://purl.uniprot.org/uniprot/A8WN62 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TUB family.|||Cell projection|||Cytoplasm|||Has a role in fat regulation independent of daf-16. Implicated in ciliar sensory function which is required for normal sensory behavior such as chemotaxis. Functions in life span control via the insulin/IGF-1 pathway. Thought to be involved in neuronal trafficking (By similarity).|||Interacts with rgb-3.|||axon|||cilium|||dendrite http://togogenome.org/gene/6238:CBG_10745 ^@ http://purl.uniprot.org/uniprot/A8XBP8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_06418 ^@ http://purl.uniprot.org/uniprot/Q04456 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Appears in mid-proliferation phase when the developing gut has four to eight cells.|||Belongs to the type-B carboxylesterase/lipase family.|||Endoplasmic reticulum lumen|||Expressed only in the intestine. http://togogenome.org/gene/6238:CBG_20861 ^@ http://purl.uniprot.org/uniprot/A8XYT4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_18439 ^@ http://purl.uniprot.org/uniprot/A8XTB4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_11702 ^@ http://purl.uniprot.org/uniprot/A8XDX5 ^@ Similarity ^@ Belongs to the GroES chaperonin family. http://togogenome.org/gene/6238:CBG_03185 ^@ http://purl.uniprot.org/uniprot/A8WSL4 ^@ Similarity ^@ Belongs to the GOLGA6 family. http://togogenome.org/gene/6238:CBG_09016 ^@ http://purl.uniprot.org/uniprot/Q61LA1 ^@ Similarity ^@ Belongs to the TTC21 family. http://togogenome.org/gene/6238:CBG_20761 ^@ http://purl.uniprot.org/uniprot/A8XYJ8 ^@ Similarity ^@ Belongs to the WASH1 family. http://togogenome.org/gene/6238:CBG_22322 ^@ http://purl.uniprot.org/uniprot/A8Y226 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/6238:CBG_08324 ^@ http://purl.uniprot.org/uniprot/A8X6A9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_06926 ^@ http://purl.uniprot.org/uniprot/A8X3D7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_18144 ^@ http://purl.uniprot.org/uniprot/A8XT42 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/6238:CBG_12483 ^@ http://purl.uniprot.org/uniprot/A8XFV4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_01246 ^@ http://purl.uniprot.org/uniprot/A8WPY0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_17827 ^@ http://purl.uniprot.org/uniprot/A8XRV3 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6238:CBG_22508 ^@ http://purl.uniprot.org/uniprot/A8Y2F5 ^@ Caution|||Function|||Similarity ^@ Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).|||Belongs to the TDD superfamily. TSR3 family.|||Belongs to the protein kinase superfamily. BUD32 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_22443 ^@ http://purl.uniprot.org/uniprot/A8Y2A9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.|||Nucleus http://togogenome.org/gene/6238:CBG_01479 ^@ http://purl.uniprot.org/uniprot/A8WQL1 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/6238:CBG_14055 ^@ http://purl.uniprot.org/uniprot/Q619W9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit H is essential for V-ATPase activity, but not for the assembly of the complex (By similarity).|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity). http://togogenome.org/gene/6238:CBG_17669 ^@ http://purl.uniprot.org/uniprot/A8XRK2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_07317 ^@ http://purl.uniprot.org/uniprot/A8X510 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/6238:CBG_16079 ^@ http://purl.uniprot.org/uniprot/A8XN55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/6238:CBG_20870 ^@ http://purl.uniprot.org/uniprot/A8XYU3 ^@ Similarity ^@ Belongs to the strictosidine synthase family. http://togogenome.org/gene/6238:CBG_11493 ^@ http://purl.uniprot.org/uniprot/A8XCV7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/6238:CBG_02821 ^@ http://purl.uniprot.org/uniprot/A8WTF7 ^@ Function|||Similarity ^@ Belongs to the MGR2 family.|||Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.|||Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation. http://togogenome.org/gene/6238:CBG_15963 ^@ http://purl.uniprot.org/uniprot/A8XND9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_09156 ^@ http://purl.uniprot.org/uniprot/A8X875 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_05998 ^@ http://purl.uniprot.org/uniprot/A8X154 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_04238 ^@ http://purl.uniprot.org/uniprot/A8WX07 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_15465 ^@ http://purl.uniprot.org/uniprot/A8XM86 ^@ Function|||Similarity ^@ Belongs to the SEC15 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/6238:CBG_01804 ^@ http://purl.uniprot.org/uniprot/A8WQS5 ^@ Function|||Subcellular Location Annotation ^@ Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_11211 ^@ http://purl.uniprot.org/uniprot/A8XCQ5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.|||Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.|||nucleolus http://togogenome.org/gene/6238:CBG_12295 ^@ http://purl.uniprot.org/uniprot/G2J6R2 ^@ Similarity ^@ Belongs to the GST superfamily. Omega family. http://togogenome.org/gene/6238:CBG_03465 ^@ http://purl.uniprot.org/uniprot/A8WV48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP18 family.|||Nucleus speckle http://togogenome.org/gene/6238:CBG_06907 ^@ http://purl.uniprot.org/uniprot/G2J6L0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit.|||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. http://togogenome.org/gene/6238:CBG_18122 ^@ http://purl.uniprot.org/uniprot/A8XT26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESS2 family.|||Nucleus http://togogenome.org/gene/6238:CBG_19423 ^@ http://purl.uniprot.org/uniprot/A8XVK8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGME1 family.|||Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance.|||Mitochondrion http://togogenome.org/gene/6238:CBG_03075 ^@ http://purl.uniprot.org/uniprot/A8WSU9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat IPI3/WDR18 family.|||Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity). Required for processing ITS2 sequences from rRNA intermediates during 26S rRNA maturation (By similarity). Required in the soma to promote normal proliferation and prevent germline tumor formation (By similarity).|||Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome particles.|||nucleolus|||nucleoplasm http://togogenome.org/gene/6238:CBG_09971 ^@ http://purl.uniprot.org/uniprot/A8XA25 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/6238:CBG_17978 ^@ http://purl.uniprot.org/uniprot/Q60Z38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Cytoplasm http://togogenome.org/gene/6238:CBG_09425 ^@ http://purl.uniprot.org/uniprot/A8X949 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/6238:CBG_21327 ^@ http://purl.uniprot.org/uniprot/A8XZU8 ^@ Similarity ^@ Belongs to the DNA polymerase type-B-like family. http://togogenome.org/gene/6238:CBG_12404 ^@ http://purl.uniprot.org/uniprot/Q61DP2 ^@ Function|||Subcellular Location Annotation ^@ Required both for centrosome duplication and maturation. Required for pericentriolar material (PCM) recruitment.|||centriole http://togogenome.org/gene/6238:CBG_23403 ^@ http://purl.uniprot.org/uniprot/A8Y400 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/6238:CBG_02970 ^@ http://purl.uniprot.org/uniprot/A8WT32 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 51 kDa subunit family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_09902 ^@ http://purl.uniprot.org/uniprot/A8X9X7 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/6238:CBG_19003 ^@ http://purl.uniprot.org/uniprot/A8XUJ7 ^@ Caution|||Similarity ^@ Belongs to the nematode receptor-like protein srg family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_15104 ^@ http://purl.uniprot.org/uniprot/G2J6V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/6238:CBG_12385 ^@ http://purl.uniprot.org/uniprot/Q95WA6 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/6238:CBG_13718 ^@ http://purl.uniprot.org/uniprot/A8XIJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT11 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/6238:CBG_23507 ^@ http://purl.uniprot.org/uniprot/A8Y3R6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Structural component of the gap junctions.|||gap junction http://togogenome.org/gene/6238:CBG_14811 ^@ http://purl.uniprot.org/uniprot/G2J6V1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||Structural component of the gap junctions.|||gap junction http://togogenome.org/gene/6238:CBG_03696 ^@ http://purl.uniprot.org/uniprot/A8WVM1 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_09820 ^@ http://purl.uniprot.org/uniprot/A8X9Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I NDUFC2 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_05736 ^@ http://purl.uniprot.org/uniprot/A8X1R7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6238:CBG_22355 ^@ http://purl.uniprot.org/uniprot/A8Y275 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/6238:CBG_03984 ^@ http://purl.uniprot.org/uniprot/A8WVX0 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/6238:CBG_03213 ^@ http://purl.uniprot.org/uniprot/A8WSJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL50 family.|||Mitochondrion http://togogenome.org/gene/6238:CBG_20109 ^@ http://purl.uniprot.org/uniprot/A8XX41 ^@ Similarity ^@ Belongs to the prokaryotic/mitochondrial release factor family. http://togogenome.org/gene/6238:CBG_22479 ^@ http://purl.uniprot.org/uniprot/A8Y2D7 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/6238:CBG_05338 ^@ http://purl.uniprot.org/uniprot/A8WZM3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_03775 ^@ http://purl.uniprot.org/uniprot/G2J6F9 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_08377 ^@ http://purl.uniprot.org/uniprot/Q61MQ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily.|||G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.|||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. http://togogenome.org/gene/6238:CBG_03795 ^@ http://purl.uniprot.org/uniprot/A8WWR3 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Proposed to have a role in neuroprotection. http://togogenome.org/gene/6238:CBG_03225 ^@ http://purl.uniprot.org/uniprot/Q61Z83 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tom40 family.|||Channel-forming protein essential for import of protein precursors into mitochondria. Specifically required for nnt-1 accumulation in the mitochondria and may be involved in the secretion of daf-28/insulin from the mitochondria. Required for embryonic and larval development.|||Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Interacts with mitochondrial targeting sequences.|||Mitochondrion outer membrane http://togogenome.org/gene/6238:CBG_20732 ^@ http://purl.uniprot.org/uniprot/A8XYH1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_22302 ^@ http://purl.uniprot.org/uniprot/A8Y210 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/6238:CBG_09323 ^@ http://purl.uniprot.org/uniprot/A8X9D2 ^@ Cofactor ^@ Divalent metal ions. Mg(2+) is the most effective. http://togogenome.org/gene/6238:CBG_01365 ^@ http://purl.uniprot.org/uniprot/A8WQ89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/6238:CBG_09413 ^@ http://purl.uniprot.org/uniprot/A8X958 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_24740 ^@ http://purl.uniprot.org/uniprot/A8WLD3 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/6238:CBG_18008 ^@ http://purl.uniprot.org/uniprot/A8XST4 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/6238:CBG_14916 ^@ http://purl.uniprot.org/uniprot/A8XKZ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm http://togogenome.org/gene/6238:CBG_20134 ^@ http://purl.uniprot.org/uniprot/A8XX56 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/6238:CBG_23295 ^@ http://purl.uniprot.org/uniprot/A8Y492 ^@ Similarity ^@ Belongs to the SNW family. http://togogenome.org/gene/6238:CBG_10794 ^@ http://purl.uniprot.org/uniprot/A8XBT5 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/6238:CBG_00206 ^@ http://purl.uniprot.org/uniprot/A8WMH0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6238:CBG_06487 ^@ http://purl.uniprot.org/uniprot/A8X2C3 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srg family. http://togogenome.org/gene/6238:CBG_12120 ^@ http://purl.uniprot.org/uniprot/A8XES9 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srg family. http://togogenome.org/gene/6238:CBG_19432 ^@ http://purl.uniprot.org/uniprot/A8XVL7 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/6238:CBG_01978 ^@ http://purl.uniprot.org/uniprot/A8WRQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FARP (FMRFamide related peptide) family.|||Secreted http://togogenome.org/gene/6238:CBG_22728 ^@ http://purl.uniprot.org/uniprot/A8Y315 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIS1 family.|||Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.|||Membrane|||Mitochondrion outer membrane|||The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission. http://togogenome.org/gene/6238:CBG_06559 ^@ http://purl.uniprot.org/uniprot/A8X2I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane http://togogenome.org/gene/6238:CBG_13668 ^@ http://purl.uniprot.org/uniprot/A8XIF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/6238:CBG_14460 ^@ http://purl.uniprot.org/uniprot/A8XJZ8 ^@ Function|||Similarity ^@ Belongs to the lst-2 family.|||Negative regulator of epidermal growth factor receptor (EGFR) signaling. http://togogenome.org/gene/6238:CBG_16755 ^@ http://purl.uniprot.org/uniprot/Q612F5 ^@ Cofactor|||Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Binds 2 magnesium or manganese ions per subunit.|||Consists of an N-terminal biotin carboxylation/carboxylase (BC) domain that catalyzes the transient carboxylation of the biotin covalently attached to the C-terminal biotinyl-binding/biotin carboxyl carrier (BCC) domain.|||Mitochondrion matrix|||The biotin cofactor is covalently attached to the C-terminal biotinyl-binding domain and is required for the catalytic activity.|||The holoenzyme is a dodecamer composed of 6 alpha subunits and 6 beta subunits. Interacts with sir-2.2.|||This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA (By similarity). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity). http://togogenome.org/gene/6238:CBG_03668 ^@ http://purl.uniprot.org/uniprot/A8WVJ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/6238:CBG_19087 ^@ http://purl.uniprot.org/uniprot/A8XUR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sre family.|||Membrane http://togogenome.org/gene/6238:CBG_12393 ^@ http://purl.uniprot.org/uniprot/A8XFB8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_20316 ^@ http://purl.uniprot.org/uniprot/A8XXJ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_24744 ^@ http://purl.uniprot.org/uniprot/A8WLD7 ^@ Similarity ^@ Belongs to the nanos family. http://togogenome.org/gene/6238:CBG_12296 ^@ http://purl.uniprot.org/uniprot/A8XF73 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_13635 ^@ http://purl.uniprot.org/uniprot/A8XID0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_11197 ^@ http://purl.uniprot.org/uniprot/A8XCP3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Required for normal brood size. May be involved in regulating mpk-1 phosphorylation downstream of phosphatase ptp-2 during oocyte maturation.|||Homodimer. http://togogenome.org/gene/6238:CBG_04949 ^@ http://purl.uniprot.org/uniprot/A8WYV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/6238:CBG_05144 ^@ http://purl.uniprot.org/uniprot/A8WZ63 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/6238:CBG_20362 ^@ http://purl.uniprot.org/uniprot/A8XXM1 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/6238:CBG_09366 ^@ http://purl.uniprot.org/uniprot/A8X994 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/6238:CBG_15010 ^@ http://purl.uniprot.org/uniprot/A8XL72 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/6238:CBG_07324 ^@ http://purl.uniprot.org/uniprot/A8X505 ^@ Similarity ^@ Belongs to the CCDC93 family. http://togogenome.org/gene/6238:CBG_12345 ^@ http://purl.uniprot.org/uniprot/A8XFM0 ^@ Similarity ^@ Belongs to the TBP family. http://togogenome.org/gene/6238:CBG_08078 ^@ http://purl.uniprot.org/uniprot/A8X5R3 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/6238:CBG_12655 ^@ http://purl.uniprot.org/uniprot/Q61D31 ^@ Domain|||Function|||Subunit ^@ Homodimer or homotetramer.|||May inhibit the chaperone activity of HSP70/HSC70 by promoting substrate release in an ATP-dependent manner.|||The BAG domain probably mediates direct interaction with HSP70. http://togogenome.org/gene/6238:CBG_02577 ^@ http://purl.uniprot.org/uniprot/A8WU02 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/6238:CBG_20902 ^@ http://purl.uniprot.org/uniprot/A8XYW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat BOP1/ERB1 family.|||Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.|||nucleolus|||nucleoplasm http://togogenome.org/gene/6238:CBG_08858 ^@ http://purl.uniprot.org/uniprot/A8X7K1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_08826 ^@ http://purl.uniprot.org/uniprot/Q61LN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF/MAK21 family.|||nucleolus http://togogenome.org/gene/6238:CBG_16744 ^@ http://purl.uniprot.org/uniprot/A8XPR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/6238:CBG_18001 ^@ http://purl.uniprot.org/uniprot/Q93148 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SPT6 family.|||Interacts with glp-1 and lin-12.|||May regulate transcriptional elongation by RNA polymerase II. May be required for several aspects of morphogenesis of C.briggsae, including regulation of division in the germline and gut and specification of ventral-uterine precursor cell fate (By similarity).|||Nucleus http://togogenome.org/gene/6238:CBG_18913 ^@ http://purl.uniprot.org/uniprot/A8XUC4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_04105 ^@ http://purl.uniprot.org/uniprot/A8WW81 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6238:CBG_14924 ^@ http://purl.uniprot.org/uniprot/A8XL04 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/6238:CBG_04578 ^@ http://purl.uniprot.org/uniprot/A8WXZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/6238:CBG_04787 ^@ http://purl.uniprot.org/uniprot/A8WYG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Membrane http://togogenome.org/gene/6238:CBG_13223 ^@ http://purl.uniprot.org/uniprot/A8XHC0 ^@ Subunit ^@ Heterodimer of 2 subunits, IMMPL1 and IMMPL2. http://togogenome.org/gene/6238:CBG_16211 ^@ http://purl.uniprot.org/uniprot/A8XNV9 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/6238:CBG_01233 ^@ http://purl.uniprot.org/uniprot/A8WPW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_12063 ^@ http://purl.uniprot.org/uniprot/A8XEG8 ^@ Function|||Similarity ^@ Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.|||Belongs to the Diphthine--ammonia ligase family. http://togogenome.org/gene/6238:CBG_19625 ^@ http://purl.uniprot.org/uniprot/A8XW18 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_00360 ^@ http://purl.uniprot.org/uniprot/A8WMW8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ACDP family.|||Cell membrane|||Membrane|||Metal transporter. http://togogenome.org/gene/6238:CBG_01898 ^@ http://purl.uniprot.org/uniprot/A8WRI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/6238:CBG_14328 ^@ http://purl.uniprot.org/uniprot/A8XJS2 ^@ Similarity ^@ Belongs to the Mo25 family. http://togogenome.org/gene/6238:CBG_02517 ^@ http://purl.uniprot.org/uniprot/A8WU48 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/6238:CBG_07355 ^@ http://purl.uniprot.org/uniprot/A8X4Y4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_12121 ^@ http://purl.uniprot.org/uniprot/A8XET0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/6238:CBG_00192 ^@ http://purl.uniprot.org/uniprot/A8WMG0 ^@ Similarity ^@ Belongs to the TAF11 family. http://togogenome.org/gene/6238:CBG_03442 ^@ http://purl.uniprot.org/uniprot/A8WV28 ^@ Similarity ^@ Belongs to the RRP1 family. http://togogenome.org/gene/6238:CBG_24154 ^@ http://purl.uniprot.org/uniprot/A8WK35 ^@ Similarity ^@ Belongs to the complex I 23 kDa subunit family. http://togogenome.org/gene/6238:CBG_13376 ^@ http://purl.uniprot.org/uniprot/A8XHX0 ^@ Function|||Similarity ^@ Belongs to the MnmG family.|||Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. http://togogenome.org/gene/6238:CBG_01211 ^@ http://purl.uniprot.org/uniprot/A8WPU7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_23319 ^@ http://purl.uniprot.org/uniprot/A8Y474 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_18828 ^@ http://purl.uniprot.org/uniprot/A8XU72 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_01691 ^@ http://purl.uniprot.org/uniprot/A8WR27 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_19287 ^@ http://purl.uniprot.org/uniprot/A8XV96 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SWEET sugar transporter family.|||Cell membrane|||Golgi apparatus membrane|||Mediates sugar transport across membranes.|||Membrane http://togogenome.org/gene/6238:CBG_03851 ^@ http://purl.uniprot.org/uniprot/A8WWX0 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_01332 ^@ http://purl.uniprot.org/uniprot/A8WQ58 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_00500 ^@ http://purl.uniprot.org/uniprot/A8WMT5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_12650 ^@ http://purl.uniprot.org/uniprot/A8XG92 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/6238:CBG_13501 ^@ http://purl.uniprot.org/uniprot/A8XI15 ^@ Function|||Similarity ^@ Belongs to the PNP/MTAP phosphorylase family.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/6238:CBG_02567 ^@ http://purl.uniprot.org/uniprot/A8WU12 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/6238:CBG_06096 ^@ http://purl.uniprot.org/uniprot/A8X0X1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Structural component of the gap junctions.|||gap junction http://togogenome.org/gene/6238:CBG_01704 ^@ http://purl.uniprot.org/uniprot/A8WR16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP2 family.|||Membrane http://togogenome.org/gene/6238:CBG_05087 ^@ http://purl.uniprot.org/uniprot/A8WZ47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_13279 ^@ http://purl.uniprot.org/uniprot/A8XHG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||nucleolus http://togogenome.org/gene/6238:CBG_01477 ^@ http://purl.uniprot.org/uniprot/A8WQL3 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/6238:CBG_07378 ^@ http://purl.uniprot.org/uniprot/A8X4W7 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/6238:CBG_03866 ^@ http://purl.uniprot.org/uniprot/A8WWY3 ^@ Similarity ^@ Belongs to the BLM10 family. http://togogenome.org/gene/6238:CBG_10311 ^@ http://purl.uniprot.org/uniprot/A8XAM5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_03958 ^@ http://purl.uniprot.org/uniprot/A8WVU8 ^@ Similarity ^@ Belongs to the villin/gelsolin family. http://togogenome.org/gene/6238:CBG_20741 ^@ http://purl.uniprot.org/uniprot/A8XYI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sre family.|||Membrane http://togogenome.org/gene/6238:CBG_12580 ^@ http://purl.uniprot.org/uniprot/A8XG34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/6238:CBG_02466 ^@ http://purl.uniprot.org/uniprot/A8WU93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/6238:CBG_06537 ^@ http://purl.uniprot.org/uniprot/A8X2G9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_06350 ^@ http://purl.uniprot.org/uniprot/A8X213 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/6238:CBG_14495 ^@ http://purl.uniprot.org/uniprot/A8XK22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_16478 ^@ http://purl.uniprot.org/uniprot/A8XP54 ^@ Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily. http://togogenome.org/gene/6238:CBG_06798 ^@ http://purl.uniprot.org/uniprot/Q61R02 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.|||Probable ATP-binding RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/6238:CBG_19425 ^@ http://purl.uniprot.org/uniprot/A8XVL0 ^@ Similarity ^@ Belongs to the MYG1 family. http://togogenome.org/gene/6238:CBG_03131 ^@ http://purl.uniprot.org/uniprot/Q61ZF6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the WD repeat G protein beta family.|||G proteins are composed of 3 units, alpha, beta and gamma. Interacts with G protein gamma subunits gpc-1 and gpc-2 and with egl-10 and eat-16. Interacts with goa-1 (in GDP-bound form).|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces. http://togogenome.org/gene/6238:CBG_13851 ^@ http://purl.uniprot.org/uniprot/A8XIV0 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/6238:CBG_06940 ^@ http://purl.uniprot.org/uniprot/A8X3E8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC16 family.|||Golgi apparatus membrane http://togogenome.org/gene/6238:CBG_09864 ^@ http://purl.uniprot.org/uniprot/A8X9U6 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/6238:CBG_03474 ^@ http://purl.uniprot.org/uniprot/A8WV56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Membrane http://togogenome.org/gene/6238:CBG_21020 ^@ http://purl.uniprot.org/uniprot/A8XZ67 ^@ Similarity ^@ Belongs to the REXO4 family. http://togogenome.org/gene/6238:CBG_14794 ^@ http://purl.uniprot.org/uniprot/G2J6V1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||Structural component of the gap junctions.|||gap junction http://togogenome.org/gene/6238:CBG_11065 ^@ http://purl.uniprot.org/uniprot/A8XCB7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_14771 ^@ http://purl.uniprot.org/uniprot/A8XKM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FARP (FMRFamide related peptide) family.|||Secreted http://togogenome.org/gene/6238:CBG_14763 ^@ http://purl.uniprot.org/uniprot/A8XKM2 ^@ Function|||Similarity ^@ Belongs to the acetyltransferase ATAT1 family.|||Specifically acetylates 'Lys-40' in alpha-tubulin/mec-12 on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for the maintenance of touch receptor neurons and possibly other type of neurons involved in locomotion. http://togogenome.org/gene/6238:CBG_01589 ^@ http://purl.uniprot.org/uniprot/A8WRA9 ^@ Similarity|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/6238:CBG_12182 ^@ http://purl.uniprot.org/uniprot/A8XF19 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NIP7 family.|||Interacts with pre-ribosome complex.|||Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.|||nucleolus http://togogenome.org/gene/6238:CBG_00425 ^@ http://purl.uniprot.org/uniprot/A8WN22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP12 family.|||Mitochondrion http://togogenome.org/gene/6238:CBG_21659 ^@ http://purl.uniprot.org/uniprot/A8Y0T6 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/6238:CBG_09014 ^@ http://purl.uniprot.org/uniprot/A8X807 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/6238:CBG_15316 ^@ http://purl.uniprot.org/uniprot/A8XLX3 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/6238:CBG_16919 ^@ http://purl.uniprot.org/uniprot/A8XQ20 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/6238:CBG_17478 ^@ http://purl.uniprot.org/uniprot/A8XR38 ^@ Caution|||Similarity ^@ Belongs to the nematode receptor-like protein srg family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_19300 ^@ http://purl.uniprot.org/uniprot/A8XVA8 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/6238:CBG_02941 ^@ http://purl.uniprot.org/uniprot/A8WT59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SARAF family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_07110 ^@ http://purl.uniprot.org/uniprot/A8X3N9 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/6238:CBG_22509 ^@ http://purl.uniprot.org/uniprot/A8Y2F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosyl-DNA phosphodiesterase family.|||Nucleus http://togogenome.org/gene/6238:CBG_11229 ^@ http://purl.uniprot.org/uniprot/A8XCH7 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_09713 ^@ http://purl.uniprot.org/uniprot/A8X8F6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||Nucleus|||Required for pre-mRNA splicing. http://togogenome.org/gene/6238:CBG_00101 ^@ http://purl.uniprot.org/uniprot/A8WMA6 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_08020 ^@ http://purl.uniprot.org/uniprot/A8X5L5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the esterase D family.|||Cytoplasm|||Serine hydrolase involved in the detoxification of formaldehyde. http://togogenome.org/gene/6238:CBG_03655 ^@ http://purl.uniprot.org/uniprot/A8WVI9 ^@ Similarity ^@ Belongs to the SCO1/2 family. http://togogenome.org/gene/6238:CBG_08956 ^@ http://purl.uniprot.org/uniprot/A8X7R3|||http://purl.uniprot.org/uniprot/A8X7R4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_10062 ^@ http://purl.uniprot.org/uniprot/Q61IU9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer. Part of the multisubunit TRAPP (transport protein particle) complex.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi. Required for the systemic spread of the RNAi response.|||cis-Golgi network http://togogenome.org/gene/6238:CBG_23101 ^@ http://purl.uniprot.org/uniprot/A8Y4P9 ^@ Similarity ^@ Belongs to the peptidase S33 family. http://togogenome.org/gene/6238:CBG_11074 ^@ http://purl.uniprot.org/uniprot/A8XCC6 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/6238:CBG_17472 ^@ http://purl.uniprot.org/uniprot/A8XR32 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. HutI family. http://togogenome.org/gene/6238:CBG_20332 ^@ http://purl.uniprot.org/uniprot/A8XXK1 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/6238:CBG_15744 ^@ http://purl.uniprot.org/uniprot/A8XMP3 ^@ Function|||Similarity ^@ Belongs to the phospholipase B-like family.|||Putative phospholipase. http://togogenome.org/gene/6238:CBG_23421 ^@ http://purl.uniprot.org/uniprot/A8Y3Y6 ^@ Similarity ^@ Belongs to the GPATCH11 family. http://togogenome.org/gene/6238:CBG_08051 ^@ http://purl.uniprot.org/uniprot/A8X5P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/6238:CBG_15837 ^@ http://purl.uniprot.org/uniprot/A8XMX3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/6238:CBG_12805 ^@ http://purl.uniprot.org/uniprot/A8XFN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.|||Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_04197 ^@ http://purl.uniprot.org/uniprot/A8WWE4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_05906 ^@ http://purl.uniprot.org/uniprot/A8X1D4 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/6238:CBG_12721 ^@ http://purl.uniprot.org/uniprot/A8XGF1 ^@ Cofactor ^@ Binds 2 iron ions per subunit. http://togogenome.org/gene/6238:CBG_11423 ^@ http://purl.uniprot.org/uniprot/A8XD21 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/6238:CBG_20609 ^@ http://purl.uniprot.org/uniprot/G2J6N5 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_07988 ^@ http://purl.uniprot.org/uniprot/A8X5I5 ^@ Function|||Similarity ^@ Belongs to the PET191 family.|||Involved in an early step of the mitochondrial complex IV assembly process. http://togogenome.org/gene/6238:CBG_19957 ^@ http://purl.uniprot.org/uniprot/A8XWT4 ^@ Function|||Similarity ^@ Belongs to the MON1/SAND family.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/6238:CBG_10496 ^@ http://purl.uniprot.org/uniprot/A8XAX9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_15340 ^@ http://purl.uniprot.org/uniprot/A8XLZ4 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/6238:CBG_17228 ^@ http://purl.uniprot.org/uniprot/A8XQI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT46 family.|||cilium|||cilium basal body http://togogenome.org/gene/6238:CBG_11707 ^@ http://purl.uniprot.org/uniprot/A8XDX1 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/6238:CBG_00342 ^@ http://purl.uniprot.org/uniprot/A8WMV5 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family. http://togogenome.org/gene/6238:CBG_01378 ^@ http://purl.uniprot.org/uniprot/A8WQ98 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with 90S and pre-40S pre-ribosomal particles.|||Belongs to the RRP36 family.|||Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.|||nucleolus http://togogenome.org/gene/6238:CBG_22219 ^@ http://purl.uniprot.org/uniprot/A8Y1T7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/6238:CBG_03966 ^@ http://purl.uniprot.org/uniprot/A8WVV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/6238:CBG_01830 ^@ http://purl.uniprot.org/uniprot/A8WQQ0 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_04073 ^@ http://purl.uniprot.org/uniprot/A8WW53 ^@ Similarity ^@ Belongs to the TBCD family. http://togogenome.org/gene/6238:CBG_16602 ^@ http://purl.uniprot.org/uniprot/A8XPK2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX. http://togogenome.org/gene/6238:CBG_00668 ^@ http://purl.uniprot.org/uniprot/A8WNB9 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/6238:CBG_15311 ^@ http://purl.uniprot.org/uniprot/A8XLW9 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. http://togogenome.org/gene/6238:CBG_11995 ^@ http://purl.uniprot.org/uniprot/A8XEA9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Structural component of the gap junctions.|||gap junction http://togogenome.org/gene/6238:CBG_19764 ^@ http://purl.uniprot.org/uniprot/A8XWD3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/6238:CBG_12936 ^@ http://purl.uniprot.org/uniprot/A8XGQ3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_05155 ^@ http://purl.uniprot.org/uniprot/A8WZ54 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the helicase family. PIF1 subfamily.|||DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.|||Mitochondrion|||Monomer.|||Nucleus http://togogenome.org/gene/6238:CBG_09807 ^@ http://purl.uniprot.org/uniprot/A8X9P3 ^@ Similarity ^@ Belongs to the pym family. http://togogenome.org/gene/6238:CBG_05011 ^@ http://purl.uniprot.org/uniprot/A8WYZ3 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/6238:CBG_19704 ^@ http://purl.uniprot.org/uniprot/Q60V43 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 7 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/6238:CBG_13128 ^@ http://purl.uniprot.org/uniprot/A8XH46 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/6238:CBG_17210 ^@ http://purl.uniprot.org/uniprot/A8XQJ8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/6238:CBG_11646 ^@ http://purl.uniprot.org/uniprot/A8XDQ0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/6238:CBG_06740 ^@ http://purl.uniprot.org/uniprot/A8X2Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_20456 ^@ http://purl.uniprot.org/uniprot/Q60TI7 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the cysteine dioxygenase family.|||Binds 1 Fe cation per subunit.|||The thioether cross-link between Cys-85 and Tyr-149 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen. http://togogenome.org/gene/6238:CBG_06960 ^@ http://purl.uniprot.org/uniprot/A8X418 ^@ Similarity ^@ Belongs to the NPL4 family. http://togogenome.org/gene/6238:CBG_22794 ^@ http://purl.uniprot.org/uniprot/A8Y2W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FARP (FMRFamide related peptide) family.|||Secreted http://togogenome.org/gene/6238:CBG_03485 ^@ http://purl.uniprot.org/uniprot/A8WV66 ^@ Similarity ^@ Belongs to the prokaryotic/mitochondrial release factor family. http://togogenome.org/gene/6238:CBG_08892 ^@ http://purl.uniprot.org/uniprot/A8X7M4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_13978 ^@ http://purl.uniprot.org/uniprot/A8XIW7 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. DDX1 subfamily.|||RNA helicase.|||The helicase domain is involved in the stimulation of RELA transcriptional activity. http://togogenome.org/gene/6238:CBG_04176 ^@ http://purl.uniprot.org/uniprot/A8WWC5 ^@ Similarity ^@ Belongs to the DCC1 family. http://togogenome.org/gene/6238:CBG_06013 ^@ http://purl.uniprot.org/uniprot/A8X139 ^@ Similarity ^@ Belongs to the peptidase A22B family. http://togogenome.org/gene/6238:CBG_01742 ^@ http://purl.uniprot.org/uniprot/A8WQY5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_02837 ^@ http://purl.uniprot.org/uniprot/A8WTE7 ^@ Similarity ^@ Belongs to the peptidase M13 family. http://togogenome.org/gene/6238:CBG_12220 ^@ http://purl.uniprot.org/uniprot/A8XEY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL43 family.|||Mitochondrion http://togogenome.org/gene/6238:CBG_09992 ^@ http://purl.uniprot.org/uniprot/A8XA45 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/6238:CBG_18993 ^@ http://purl.uniprot.org/uniprot/A8XUI8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_13601 ^@ http://purl.uniprot.org/uniprot/A8XIA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.|||Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.|||Nucleus http://togogenome.org/gene/6238:CBG_09068 ^@ http://purl.uniprot.org/uniprot/A8X7V7 ^@ Similarity|||Subunit ^@ Belongs to the peptidase M18 family.|||Tetrahedron-shaped homododecamer built from six homodimers. http://togogenome.org/gene/6238:CBG_09253 ^@ http://purl.uniprot.org/uniprot/Q61KR9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calreticulin family.|||Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity (By similarity).|||Endoplasmic reticulum lumen|||Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Probably by controlling the folding of extracellular matrix protein unc-52/Perlecan, may play a role in the formation of fibrous organelles, a hemidesmosome-like structure attaching muscles to the epidermis. Protects dopaminergic neurons against oxidative stress-induced neurodegeneration (By similarity).|||The interaction with glycans occurs through a binding site in the globular lectin domain.|||The zinc binding sites are localized to the N-domain. http://togogenome.org/gene/6238:CBG_12957 ^@ http://purl.uniprot.org/uniprot/A8XGR6 ^@ Function|||Similarity ^@ Belongs to the SKP1 family.|||Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. http://togogenome.org/gene/6238:CBG_04440 ^@ http://purl.uniprot.org/uniprot/A8WXK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Cell membrane http://togogenome.org/gene/6238:CBG_12343 ^@ http://purl.uniprot.org/uniprot/A8XFL8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Non-catalytic component of the proteasome.|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. http://togogenome.org/gene/6238:CBG_03420 ^@ http://purl.uniprot.org/uniprot/A8WV08 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_16375 ^@ http://purl.uniprot.org/uniprot/A8XNK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus|||Orphan nuclear receptor. http://togogenome.org/gene/6238:CBG_18941 ^@ http://purl.uniprot.org/uniprot/A8XUE5 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/6238:CBG_13159 ^@ http://purl.uniprot.org/uniprot/A8XH72 ^@ Caution|||Cofactor|||Function ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Metalloprotease. http://togogenome.org/gene/6238:CBG_08128 ^@ http://purl.uniprot.org/uniprot/A8X5V8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_01010 ^@ http://purl.uniprot.org/uniprot/A8WP43 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/6238:CBG_20702 ^@ http://purl.uniprot.org/uniprot/E3CU79 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/6238:CBG_08070 ^@ http://purl.uniprot.org/uniprot/A8X5Q7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Melanosome|||Membrane|||SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.|||cis-Golgi network membrane http://togogenome.org/gene/6238:CBG_19269 ^@ http://purl.uniprot.org/uniprot/A8XV82 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/6238:CBG_23841 ^@ http://purl.uniprot.org/uniprot/A8WJF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BOD1 family.|||centrosome|||kinetochore http://togogenome.org/gene/6238:CBG_17275 ^@ http://purl.uniprot.org/uniprot/A8XQR1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_06190 ^@ http://purl.uniprot.org/uniprot/A8X0Q0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/6238:CBG_12401 ^@ http://purl.uniprot.org/uniprot/A8XFC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Membrane|||Microsome membrane http://togogenome.org/gene/6238:CBG_03543 ^@ http://purl.uniprot.org/uniprot/A8WVA8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NADPH--cytochrome P450 reductase family.|||Binds 1 FAD per monomer.|||Binds 1 FMN per monomer.|||Endoplasmic reticulum membrane|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. http://togogenome.org/gene/6238:CBG_11007 ^@ http://purl.uniprot.org/uniprot/A8XC11 ^@ Similarity ^@ Belongs to the FAM122 family. http://togogenome.org/gene/6238:CBG_06800 ^@ http://purl.uniprot.org/uniprot/A8X339 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP9 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm http://togogenome.org/gene/6238:CBG_21735 ^@ http://purl.uniprot.org/uniprot/A8Y0L8 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_05747 ^@ http://purl.uniprot.org/uniprot/A8X1Q8 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/6238:CBG_19171 ^@ http://purl.uniprot.org/uniprot/A8XV00 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/6238:CBG_01160 ^@ http://purl.uniprot.org/uniprot/A8WPQ2 ^@ Similarity ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. http://togogenome.org/gene/6238:CBG_17994 ^@ http://purl.uniprot.org/uniprot/A8XSS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uS2 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with rps-21.|||Cytoplasm|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. http://togogenome.org/gene/6238:CBG_09138 ^@ http://purl.uniprot.org/uniprot/A8X861 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/6238:CBG_01053 ^@ http://purl.uniprot.org/uniprot/Q626B1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase during oocyte maturation. Required for embryonic development, germline proliferation and initiation of meiosis during spermatogenesis. Required for chromosome structure during mitosis and negative regulation of nuclear envelope breakdown (By similarity).|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.|||Cytoplasm|||Golgi apparatus membrane http://togogenome.org/gene/6238:CBG_01506 ^@ http://purl.uniprot.org/uniprot/G2J745 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_04313 ^@ http://purl.uniprot.org/uniprot/Q61WP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPG5 family.|||Cytoplasm|||Involved in autophagy. Has a role in the degradation of protein aggregates within autophagosomes. Essential for starvation-induced autotrophy and omegasome development (By similarity). http://togogenome.org/gene/6238:CBG_13352 ^@ http://purl.uniprot.org/uniprot/A8XHZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Nucleus http://togogenome.org/gene/6238:CBG_22670 ^@ http://purl.uniprot.org/uniprot/A8Y2U0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_15353 ^@ http://purl.uniprot.org/uniprot/G2J6B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/6238:CBG_09355 ^@ http://purl.uniprot.org/uniprot/A8X9A4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOSR2 family.|||Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.|||Membrane http://togogenome.org/gene/6238:CBG_16516 ^@ http://purl.uniprot.org/uniprot/A8XPD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM147 family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_17683 ^@ http://purl.uniprot.org/uniprot/Q60ZR7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ric-3 family.|||Endoplasmic reticulum membrane|||Interacts with the deg-3/des-2 acetylcholine receptor.|||Required for maturation and cell surface expression of acetylcholine receptors. http://togogenome.org/gene/6238:CBG_10474 ^@ http://purl.uniprot.org/uniprot/A8XBB0 ^@ Similarity ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. http://togogenome.org/gene/6238:CBG_14858 ^@ http://purl.uniprot.org/uniprot/A8XKU8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_22046 ^@ http://purl.uniprot.org/uniprot/A8Y1E8 ^@ Similarity ^@ Belongs to the SERF family. http://togogenome.org/gene/6238:CBG_18319 ^@ http://purl.uniprot.org/uniprot/A8XSF1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/6238:CBG_04950 ^@ http://purl.uniprot.org/uniprot/A8WYV6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_02487 ^@ http://purl.uniprot.org/uniprot/A8WU74 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/6238:CBG_19080 ^@ http://purl.uniprot.org/uniprot/A8XUR1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_22952 ^@ http://purl.uniprot.org/uniprot/A8Y3L0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_23279 ^@ http://purl.uniprot.org/uniprot/Q67EQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/6238:CBG_19039 ^@ http://purl.uniprot.org/uniprot/A8XUM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/6238:CBG_04431 ^@ http://purl.uniprot.org/uniprot/A8WXJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/6238:CBG_01816 ^@ http://purl.uniprot.org/uniprot/A8WQR3 ^@ Caution|||Similarity ^@ Belongs to the CRELD family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_03928 ^@ http://purl.uniprot.org/uniprot/A8WVS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM53 family.|||Membrane|||Nucleus outer membrane http://togogenome.org/gene/6238:CBG_07625 ^@ http://purl.uniprot.org/uniprot/A8X4F1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Structural component of the gap junctions.|||gap junction http://togogenome.org/gene/6238:CBG_03429 ^@ http://purl.uniprot.org/uniprot/A8WV16 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/6238:CBG_07736 ^@ http://purl.uniprot.org/uniprot/A8X470 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum-Golgi intermediate compartment membrane http://togogenome.org/gene/6238:CBG_02283 ^@ http://purl.uniprot.org/uniprot/G2J6N5 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_20025 ^@ http://purl.uniprot.org/uniprot/A8XWY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/6238:CBG_07047 ^@ http://purl.uniprot.org/uniprot/A8X3U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty-acid and retinol-binding protein (FARBP) family.|||Secreted http://togogenome.org/gene/6238:CBG_12445 ^@ http://purl.uniprot.org/uniprot/A8XFG2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 20 kDa subunit family.|||Binds 1 [4Fe-4S] cluster.|||Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).|||Mitochondrion http://togogenome.org/gene/6238:CBG_07380 ^@ http://purl.uniprot.org/uniprot/A8X4W5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_04218 ^@ http://purl.uniprot.org/uniprot/A8WWF9 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/6238:CBG_15022 ^@ http://purl.uniprot.org/uniprot/A8XL80 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_18097 ^@ http://purl.uniprot.org/uniprot/A8XT10 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_13375 ^@ http://purl.uniprot.org/uniprot/A8XHX1 ^@ Similarity ^@ Belongs to the TTC36 family. http://togogenome.org/gene/6238:CBG_08489 ^@ http://purl.uniprot.org/uniprot/A8X6P3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_13527 ^@ http://purl.uniprot.org/uniprot/A8XI37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.|||Membrane http://togogenome.org/gene/6238:CBG_00465 ^@ http://purl.uniprot.org/uniprot/A8WMQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL40 family.|||Mitochondrion http://togogenome.org/gene/6238:CBG_03050 ^@ http://purl.uniprot.org/uniprot/A8WSW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDCD10 family.|||Cytoplasm http://togogenome.org/gene/6238:CBG_23621 ^@ http://purl.uniprot.org/uniprot/A8WIY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLM family.|||Membrane http://togogenome.org/gene/6238:CBG_13188 ^@ http://purl.uniprot.org/uniprot/Q17308 ^@ Disruption Phenotype|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GLI C2H2-type zinc-finger protein family.|||Cytoplasm|||Interacts with the MX regulatory domain of tra-2.|||Nucleus|||Null mutants exhibit strong masculinization and male mating behavior. XX male mutants are infertile, produce sperm from day one of adulthood, but by day three of adulthood, switch from spermatogenesis to oogenesis and produce irregular oocytes. Mutants display early somatic gonad precursor lineage defects, whereby Z1 precursors divide with reverse polarity and Z4 precursors migrate prematurely. Most animals rectify these defects to produce normal male somatic gonad. RNAi-mediated knock-down in XO male animals yields a partially feminized germ line that contains both sperm and oocytes in males, but not hermaphrodites.|||Only isoform a is thought to bind DNA. Zinc fingers 3, 4 and 5 are the most important for DNA binding; removal of finger 5 almost abolishes DNA binding and prevents the selection of binding sites.|||Plays a major role in controlling sexual phenotype (PubMed:18245372). Terminal global regulator in a well-characterized cascade of sex-determining genes (By similarity). Promotes female development (By similarity). Interacts with tra-2 to promote spermatogenesis (PubMed:11250902). Promotes spermatogenesis through the Tip60 HAT complex and by regulating the expression of genes, such as fog-3, required for male development (PubMed:24098152). Association with chromatin and at the fog-3 promoter requires wdr-5.1, and may also require wdr-5.2 (By similarity). With trr-1, activates the fog-3 gene to determine sperm/oocyte cell fate (PubMed:24098152). In hermaphrodites, binds to an intronic regulatory site in the ceh-30 gene, preventing ceh-30 transcription and thereby preventing survival of the CEM (cephalic male) sensory neurons (By similarity). Represses the expression of the transcription factor dmd-3 in hermaphrodites to govern the timing and extent of male tail tip morphogenesis (By similarity). Plays a role in controlling the sex-specific differentiation of PHC sensory neurons and represses the development of male-specific morphological features (By similarity). http://togogenome.org/gene/6238:CBG_20576 ^@ http://purl.uniprot.org/uniprot/A8XY44 ^@ Similarity ^@ Belongs to the exportin family. http://togogenome.org/gene/6238:CBG_04756 ^@ http://purl.uniprot.org/uniprot/A8WYE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis. Phosphorylates and restricts the asymmetry effector mex-5 (and possibly also mex-6) to the anterior cytoplasm of the zygote. Regulates mes-1 expression during early embryogenesis. Critical role in postembryonic vulval morphogenesis.|||cell cortex http://togogenome.org/gene/6238:CBG_00747 ^@ http://purl.uniprot.org/uniprot/A8WN56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cystinosin family.|||Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes (By similarity). May play a role in the degradation of engulfed apoptotic cells (By similarity).|||Lysosome membrane|||phagosome http://togogenome.org/gene/6238:CBG_12500 ^@ http://purl.uniprot.org/uniprot/A8XFW9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family. CPSF5 subfamily.|||Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.|||Cytoplasm|||Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.|||Nucleus http://togogenome.org/gene/6238:CBG_17948 ^@ http://purl.uniprot.org/uniprot/A8XSM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARPC4 family.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.|||cytoskeleton http://togogenome.org/gene/6238:CBG_20793 ^@ http://purl.uniprot.org/uniprot/A8XYM7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_17384 ^@ http://purl.uniprot.org/uniprot/A8XQY3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/6238:CBG_04591 ^@ http://purl.uniprot.org/uniprot/A8WY04 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/6238:CBG_05589 ^@ http://purl.uniprot.org/uniprot/A8X080 ^@ Similarity ^@ Belongs to the ERG4/ERG24 family. http://togogenome.org/gene/6238:CBG_07632 ^@ http://purl.uniprot.org/uniprot/A8X4E6 ^@ Function|||Similarity ^@ Belongs to the phospholipase B-like family.|||Putative phospholipase. http://togogenome.org/gene/6238:CBG_10155 ^@ http://purl.uniprot.org/uniprot/A8XAI2 ^@ Function|||Similarity ^@ Belongs to the RNase H family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. http://togogenome.org/gene/6238:CBG_12825 ^@ http://purl.uniprot.org/uniprot/A8XFP9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_23146 ^@ http://purl.uniprot.org/uniprot/A8Y4L4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI inositol-deacylase family.|||Endoplasmic reticulum membrane|||Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.|||Membrane http://togogenome.org/gene/6238:CBG_16619 ^@ http://purl.uniprot.org/uniprot/A8XPL6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/6238:CBG_21106 ^@ http://purl.uniprot.org/uniprot/A8XZG7 ^@ Function|||Similarity ^@ Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.|||Belongs to the NMT family. http://togogenome.org/gene/6238:CBG_06810 ^@ http://purl.uniprot.org/uniprot/A8X346 ^@ Similarity ^@ Belongs to the AccD/PCCB family. http://togogenome.org/gene/6238:CBG_19011 ^@ http://purl.uniprot.org/uniprot/A8XUK2 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/6238:CBG_07091 ^@ http://purl.uniprot.org/uniprot/A8X3Q4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/6238:CBG_20692 ^@ http://purl.uniprot.org/uniprot/A8XYE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the wntless family.|||Endosome membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/6238:CBG_10083 ^@ http://purl.uniprot.org/uniprot/A8XAC5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_02198 ^@ http://purl.uniprot.org/uniprot/A8WSB0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.|||Membrane http://togogenome.org/gene/6238:CBG_22774 ^@ http://purl.uniprot.org/uniprot/A8Y2V4 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/6238:CBG_15025 ^@ http://purl.uniprot.org/uniprot/A8XL82 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_00768 ^@ http://purl.uniprot.org/uniprot/A8WNS4 ^@ Similarity ^@ Belongs to the BROX family. http://togogenome.org/gene/6238:CBG_22969 ^@ http://purl.uniprot.org/uniprot/A8Y3J7 ^@ Function|||Similarity ^@ Belongs to the IPP isomerase type 1 family.|||Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/6238:CBG_01022 ^@ http://purl.uniprot.org/uniprot/A8WP33 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/6238:CBG_17593 ^@ http://purl.uniprot.org/uniprot/A8XRB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_18786 ^@ http://purl.uniprot.org/uniprot/A8XU42 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/6238:CBG_10410 ^@ http://purl.uniprot.org/uniprot/A8XB52 ^@ Similarity ^@ Belongs to the GST superfamily. Kappa family. http://togogenome.org/gene/6238:CBG_11706 ^@ http://purl.uniprot.org/uniprot/A8XDX2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase C chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c (By similarity).|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element (By similarity).|||Mitochondrion membrane|||Trimethylated by ATPSCKMT at Lys-84. Methylation may be required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration. http://togogenome.org/gene/6238:CBG_09991 ^@ http://purl.uniprot.org/uniprot/A8XA44 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/6238:CBG_00433 ^@ http://purl.uniprot.org/uniprot/A8WN29 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/6238:CBG_15765 ^@ http://purl.uniprot.org/uniprot/A8XMR1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 5A family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_21260 ^@ http://purl.uniprot.org/uniprot/A8XZQ0 ^@ Similarity ^@ Belongs to the CWC16 family. http://togogenome.org/gene/6238:CBG_20094 ^@ http://purl.uniprot.org/uniprot/A8XX28 ^@ Similarity ^@ Belongs to the GOLGA6 family. http://togogenome.org/gene/6238:CBG_15755 ^@ http://purl.uniprot.org/uniprot/A8XMQ1 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/6238:CBG_16451 ^@ http://purl.uniprot.org/uniprot/A8XP38 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. http://togogenome.org/gene/6238:CBG_09504 ^@ http://purl.uniprot.org/uniprot/A8X8Y6 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/6238:CBG_22269 ^@ http://purl.uniprot.org/uniprot/A8Y1Y0 ^@ Function|||Similarity ^@ Belongs to the EAF family.|||Promotes transcriptional elongation by Su(Tpl)/ELL. Essential for development. http://togogenome.org/gene/6238:CBG_20711 ^@ http://purl.uniprot.org/uniprot/A8XYF8 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/6238:CBG_08301 ^@ http://purl.uniprot.org/uniprot/A8X691 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/6238:CBG_19635 ^@ http://purl.uniprot.org/uniprot/A8XW26 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/6238:CBG_17856 ^@ http://purl.uniprot.org/uniprot/A8XRX5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_01234 ^@ http://purl.uniprot.org/uniprot/A8WPW9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_23397 ^@ http://purl.uniprot.org/uniprot/A8Y406 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_12038 ^@ http://purl.uniprot.org/uniprot/A8XEE8 ^@ Function|||Similarity ^@ Belongs to the RRF family.|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/6238:CBG_13246 ^@ http://purl.uniprot.org/uniprot/A8XHE2 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/6238:CBG_00344 ^@ http://purl.uniprot.org/uniprot/A8WMV6 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family. http://togogenome.org/gene/6238:CBG_06288 ^@ http://purl.uniprot.org/uniprot/A8X1V8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_11728 ^@ http://purl.uniprot.org/uniprot/A8XDV4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.|||Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS).|||Monomer. http://togogenome.org/gene/6238:CBG_08282 ^@ http://purl.uniprot.org/uniprot/Q4VYB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/6238:CBG_10568 ^@ http://purl.uniprot.org/uniprot/A8XBC4 ^@ Similarity ^@ Belongs to the ATG101 family. http://togogenome.org/gene/6238:CBG_23058 ^@ http://purl.uniprot.org/uniprot/A8Y4T3 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_22279 ^@ http://purl.uniprot.org/uniprot/A8Y1Z0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_07708 ^@ http://purl.uniprot.org/uniprot/A8X488 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. http://togogenome.org/gene/6238:CBG_13634 ^@ http://purl.uniprot.org/uniprot/A8XIC9 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/6238:CBG_15152 ^@ http://purl.uniprot.org/uniprot/P90727 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the splicing factor SR family.|||Forms a heterodimer with the U2AF small subunit.|||Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly (By similarity).|||Nucleus http://togogenome.org/gene/6238:CBG_16268 ^@ http://purl.uniprot.org/uniprot/A8XNS2 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/6238:CBG_16622 ^@ http://purl.uniprot.org/uniprot/A8XP60 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/6238:CBG_23625 ^@ http://purl.uniprot.org/uniprot/A8WIY8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer. http://togogenome.org/gene/6238:CBG_01806 ^@ http://purl.uniprot.org/uniprot/P61865 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL11 family.|||Binds directly to 26S ribosomal RNA. http://togogenome.org/gene/6238:CBG_00458 ^@ http://purl.uniprot.org/uniprot/A8WN51 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.|||Binds 1 Mg(2+) ion per subunit.|||GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.|||Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.|||Mitochondrion http://togogenome.org/gene/6238:CBG_04191 ^@ http://purl.uniprot.org/uniprot/A8WWD8 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_18240 ^@ http://purl.uniprot.org/uniprot/G2J6X7 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/6238:CBG_09994 ^@ http://purl.uniprot.org/uniprot/Q61J08 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the mcm2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order mcm2-mcm6-mcm4-mcm7-mcm3-mcm5 (By simililarity).|||Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.|||Nucleus http://togogenome.org/gene/6238:CBG_00616 ^@ http://purl.uniprot.org/uniprot/A8WNG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0389 family.|||Membrane http://togogenome.org/gene/6238:CBG_10813 ^@ http://purl.uniprot.org/uniprot/A8XBV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.|||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. http://togogenome.org/gene/6238:CBG_22542 ^@ http://purl.uniprot.org/uniprot/A8Y2I5 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_10165 ^@ http://purl.uniprot.org/uniprot/A8XAI9 ^@ Subcellular Location Annotation ^@ centromere http://togogenome.org/gene/6238:CBG_20773 ^@ http://purl.uniprot.org/uniprot/A8XYK8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRQ/QCR8 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_14137 ^@ http://purl.uniprot.org/uniprot/P32809 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/6238:CBG_03148 ^@ http://purl.uniprot.org/uniprot/A8WSP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/6238:CBG_01023 ^@ http://purl.uniprot.org/uniprot/A8WP32 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/6238:CBG_12670 ^@ http://purl.uniprot.org/uniprot/A8XGA9 ^@ Similarity ^@ Belongs to the complex I 30 kDa subunit family. http://togogenome.org/gene/6238:CBG_11232 ^@ http://purl.uniprot.org/uniprot/A8XCI0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_19070 ^@ http://purl.uniprot.org/uniprot/Q60WM1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 6 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex. Interacts with let-19/mdt-13. Interacts with RNA polymerase II. Interacts with mdt-28.|||Nucleus http://togogenome.org/gene/6238:CBG_08856 ^@ http://purl.uniprot.org/uniprot/A8X7J9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_23428 ^@ http://purl.uniprot.org/uniprot/A8Y3X9 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Mitochondrion|||This protein may be expected to contain an N-terminal transit peptide but none has been predicted. http://togogenome.org/gene/6238:CBG_07858 ^@ http://purl.uniprot.org/uniprot/A8X5A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/6238:CBG_20771 ^@ http://purl.uniprot.org/uniprot/A8XYK6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_08425 ^@ http://purl.uniprot.org/uniprot/A8X6I9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm|||Heterooligomeric complex.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. Required for correct subcellular localization of pgl-1 (By similarity). http://togogenome.org/gene/6238:CBG_11296 ^@ http://purl.uniprot.org/uniprot/A8XDC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/6238:CBG_10427 ^@ http://purl.uniprot.org/uniprot/A8XB68 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_20791 ^@ http://purl.uniprot.org/uniprot/G2J716 ^@ Similarity ^@ Belongs to the pseudouridine synthase Pus10 family. http://togogenome.org/gene/6238:CBG_13174 ^@ http://purl.uniprot.org/uniprot/A8XH82 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAPC3/SRD2 family.|||Nucleus|||Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.|||Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. http://togogenome.org/gene/6238:CBG_05841 ^@ http://purl.uniprot.org/uniprot/A8X1I1 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/6238:CBG_23256 ^@ http://purl.uniprot.org/uniprot/A8Y4C5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/6238:CBG_02936 ^@ http://purl.uniprot.org/uniprot/A8WT63 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_19777 ^@ http://purl.uniprot.org/uniprot/A8XWC2 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/6238:CBG_01785 ^@ http://purl.uniprot.org/uniprot/A8WQU3 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/6238:CBG_09310 ^@ http://purl.uniprot.org/uniprot/A8X9E4 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_19742 ^@ http://purl.uniprot.org/uniprot/P0C655 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the jagunal family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/6238:CBG_09125 ^@ http://purl.uniprot.org/uniprot/A8X854 ^@ Function|||Similarity ^@ Belongs to the SKP1 family.|||Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. http://togogenome.org/gene/6238:CBG_01243 ^@ http://purl.uniprot.org/uniprot/A8WPX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_08749 ^@ http://purl.uniprot.org/uniprot/A8X7A9 ^@ Function|||Similarity ^@ Belongs to the non-lysosomal glucosylceramidase family.|||Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. http://togogenome.org/gene/6238:CBG_17899 ^@ http://purl.uniprot.org/uniprot/A8XS22 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_09953 ^@ http://purl.uniprot.org/uniprot/G2J6N5 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_22293 ^@ http://purl.uniprot.org/uniprot/A8Y201 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/6238:CBG_20788 ^@ http://purl.uniprot.org/uniprot/G2J716 ^@ Similarity ^@ Belongs to the pseudouridine synthase Pus10 family. http://togogenome.org/gene/6238:CBG_23457 ^@ http://purl.uniprot.org/uniprot/A8Y3V5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tom20 family.|||Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore (By similarity).|||Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex).|||Mitochondrion outer membrane http://togogenome.org/gene/6238:CBG_08819 ^@ http://purl.uniprot.org/uniprot/A8X7G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/6238:CBG_07592 ^@ http://purl.uniprot.org/uniprot/A8X4H5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_20329 ^@ http://purl.uniprot.org/uniprot/A8XXJ9 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/6238:CBG_04517 ^@ http://purl.uniprot.org/uniprot/A8WXP7 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/6238:CBG_12642 ^@ http://purl.uniprot.org/uniprot/Q61D43 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 18 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/6238:CBG_19886 ^@ http://purl.uniprot.org/uniprot/A8XWN4 ^@ Similarity ^@ Belongs to the beclin family. http://togogenome.org/gene/6238:CBG_20704 ^@ http://purl.uniprot.org/uniprot/A8XYF2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/6238:CBG_16672 ^@ http://purl.uniprot.org/uniprot/A8XPA3 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family. http://togogenome.org/gene/6238:CBG_00820 ^@ http://purl.uniprot.org/uniprot/A8WNX0 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/6238:CBG_18020 ^@ http://purl.uniprot.org/uniprot/A8XSU5 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srg family. http://togogenome.org/gene/6238:CBG_18134 ^@ http://purl.uniprot.org/uniprot/A8XT34 ^@ Similarity ^@ Belongs to the DDRGK1 family. http://togogenome.org/gene/6238:CBG_05278 ^@ http://purl.uniprot.org/uniprot/A8WZI8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_16827 ^@ http://purl.uniprot.org/uniprot/A8XPW5 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/6238:CBG_12520 ^@ http://purl.uniprot.org/uniprot/Q61DE0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the G-alpha family.|||G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.|||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. http://togogenome.org/gene/6238:CBG_01586 ^@ http://purl.uniprot.org/uniprot/A8WRB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/6238:CBG_01116 ^@ http://purl.uniprot.org/uniprot/A8WPL3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_13210 ^@ http://purl.uniprot.org/uniprot/A8XHB0 ^@ Similarity ^@ Belongs to the DENR family. http://togogenome.org/gene/6238:CBG_16136 ^@ http://purl.uniprot.org/uniprot/A8XP14 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GOSR2 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.|||Part of a unique SNARE complex.|||cis-Golgi network membrane http://togogenome.org/gene/6238:CBG_09409 ^@ http://purl.uniprot.org/uniprot/Q86FX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-alpha family.|||G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site (By similarity).|||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. This specific G-alpha subunit plays an important role in olfaction and in cilia morphogenesis. Involved in chemotactic responses to attractants diacetyl, pyrazine, 2,4,5-trimethylthiazole, benzaldehyde, isoamyl alcohol, butanone and 2,3-pentanedione. Displays a redundant function with gpa-3 in chemotactic responses. Involved in avoidance responses to copper, sodium dodecyl sulfate and linoleic acid. Involved in osmotic avoidance and mechanosensory responses. Involved in specifying fan-like morphology of cilia of head sensory neurons AWC (By similarity).|||cilium|||dendrite http://togogenome.org/gene/6238:CBG_17892 ^@ http://purl.uniprot.org/uniprot/A8XS15 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. http://togogenome.org/gene/6238:CBG_09643 ^@ http://purl.uniprot.org/uniprot/Q61JT8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (By similarity).|||Belongs to the VPS54 family.|||Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54.|||trans-Golgi network http://togogenome.org/gene/6238:CBG_15188 ^@ http://purl.uniprot.org/uniprot/A8XLQ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gemin-2 family.|||Cytoplasm|||Part of the core SMN complex.|||The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. http://togogenome.org/gene/6238:CBG_18062 ^@ http://purl.uniprot.org/uniprot/A8XSY1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_08803 ^@ http://purl.uniprot.org/uniprot/A8X7F4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_05961 ^@ http://purl.uniprot.org/uniprot/A8X183 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/6238:CBG_05588 ^@ http://purl.uniprot.org/uniprot/A8X079 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/6238:CBG_10544 ^@ http://purl.uniprot.org/uniprot/A8XBE1 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/6238:CBG_16729 ^@ http://purl.uniprot.org/uniprot/A8XPP9 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/6238:CBG_07448 ^@ http://purl.uniprot.org/uniprot/A8X4R0 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_22982 ^@ http://purl.uniprot.org/uniprot/A8Y3I5 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/6238:CBG_18693 ^@ http://purl.uniprot.org/uniprot/A8XTW3 ^@ Cofactor|||Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/6238:CBG_08278 ^@ http://purl.uniprot.org/uniprot/A8X672 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_03771 ^@ http://purl.uniprot.org/uniprot/A8WWP3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/6238:CBG_05815 ^@ http://purl.uniprot.org/uniprot/A8X1K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/6238:CBG_15006 ^@ http://purl.uniprot.org/uniprot/A8XL71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_19152 ^@ http://purl.uniprot.org/uniprot/A8XUY2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/6238:CBG_02609 ^@ http://purl.uniprot.org/uniprot/A8WTX6 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_10454 ^@ http://purl.uniprot.org/uniprot/A8XB93 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/6238:CBG_12785 ^@ http://purl.uniprot.org/uniprot/A8XGK1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/6238:CBG_19906 ^@ http://purl.uniprot.org/uniprot/A8XWQ0 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srd family. http://togogenome.org/gene/6238:CBG_13226 ^@ http://purl.uniprot.org/uniprot/A8XHC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad1 family.|||Nucleus http://togogenome.org/gene/6238:CBG_08080 ^@ http://purl.uniprot.org/uniprot/A8X5R5 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/6238:CBG_20070 ^@ http://purl.uniprot.org/uniprot/A8XX09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/6238:CBG_04135 ^@ http://purl.uniprot.org/uniprot/A8WVM9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/6238:CBG_16408 ^@ http://purl.uniprot.org/uniprot/A8XNI2 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/6238:CBG_10720 ^@ http://purl.uniprot.org/uniprot/A8XBM5 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_09248 ^@ http://purl.uniprot.org/uniprot/A8X9J1 ^@ Similarity ^@ Belongs to the CWF19 family. http://togogenome.org/gene/6238:CBG_19062 ^@ http://purl.uniprot.org/uniprot/A8XUP5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_17483 ^@ http://purl.uniprot.org/uniprot/A8XR34 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srg family. http://togogenome.org/gene/6238:CBG_21809 ^@ http://purl.uniprot.org/uniprot/A8Y0V2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_05833 ^@ http://purl.uniprot.org/uniprot/A8X1I9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS8 family. http://togogenome.org/gene/6238:CBG_10214 ^@ http://purl.uniprot.org/uniprot/A8XAU4 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.|||Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.|||In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.|||Nucleus http://togogenome.org/gene/6238:CBG_09151 ^@ http://purl.uniprot.org/uniprot/A8X870 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. MFSD6 family.|||Membrane http://togogenome.org/gene/6238:CBG_09516 ^@ http://purl.uniprot.org/uniprot/A8X8X5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/6238:CBG_02659 ^@ http://purl.uniprot.org/uniprot/A8WTT4 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/6238:CBG_13569 ^@ http://purl.uniprot.org/uniprot/A8XI75 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.|||Chromosome|||In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.|||Nucleus|||Probable histone methyltransferase required for embryonic development. http://togogenome.org/gene/6238:CBG_02501 ^@ http://purl.uniprot.org/uniprot/A8WU63 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/6238:CBG_14574 ^@ http://purl.uniprot.org/uniprot/A8Y4R0 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/6238:CBG_03935 ^@ http://purl.uniprot.org/uniprot/A8WVT0 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/6238:CBG_01745 ^@ http://purl.uniprot.org/uniprot/A8WQY2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL20 family. http://togogenome.org/gene/6238:CBG_10912 ^@ http://purl.uniprot.org/uniprot/A8XC92 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway (By similarity).|||Belongs to the nematode receptor-like protein str family.|||Interacts with odr-4.|||cilium membrane http://togogenome.org/gene/6238:CBG_00649 ^@ http://purl.uniprot.org/uniprot/A8WND4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_13185 ^@ http://purl.uniprot.org/uniprot/A8XH91 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_20548 ^@ http://purl.uniprot.org/uniprot/A8XY21 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_00970 ^@ http://purl.uniprot.org/uniprot/A8WP76 ^@ Function|||Similarity ^@ Belongs to the 3-oxoacid CoA-transferase family.|||Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. http://togogenome.org/gene/6238:CBG_07853 ^@ http://purl.uniprot.org/uniprot/A8X5A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/6238:CBG_02768 ^@ http://purl.uniprot.org/uniprot/Q8MUK1 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/6238:CBG_20205 ^@ http://purl.uniprot.org/uniprot/A8XX72 ^@ Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family. http://togogenome.org/gene/6238:CBG_01242 ^@ http://purl.uniprot.org/uniprot/A8WPX6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_20206 ^@ http://purl.uniprot.org/uniprot/A8XX71 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6238:CBG_18029 ^@ http://purl.uniprot.org/uniprot/A8XSV3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat neurobeachin family.|||Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. Regulates endosomal traffic in polarized epithelial cells such as the vulval precursor cells and intestinal cells. Thought to act as a negative regulator of lin-12 activity in vulval precursor cells. May have a role in the internalization process from basolateral surface of polarized epithelial cells (By similarity).|||Cytoplasm|||Interacts with RII subunit of PKA.|||Membrane|||Nucleus http://togogenome.org/gene/6238:CBG_16850 ^@ http://purl.uniprot.org/uniprot/A8XPY1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/6238:CBG_13531 ^@ http://purl.uniprot.org/uniprot/A8XI41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/6238:CBG_17740 ^@ http://purl.uniprot.org/uniprot/Q60ZM2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ELP4 family.|||Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.|||Component of the elongator complex.|||Cytoplasm|||Nucleus|||The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification. http://togogenome.org/gene/6238:CBG_05840 ^@ http://purl.uniprot.org/uniprot/G2J6I6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_05468 ^@ http://purl.uniprot.org/uniprot/A8WZY3 ^@ Similarity ^@ Belongs to the BLOC1S2 family. http://togogenome.org/gene/6238:CBG_01308 ^@ http://purl.uniprot.org/uniprot/A8WQ38 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/6238:CBG_13026 ^@ http://purl.uniprot.org/uniprot/O97472 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.|||Belongs to the replication factor A protein 1 family.|||Component of the heterotrimeric canonical replication protein A complex (RPA).|||Nucleus http://togogenome.org/gene/6238:CBG_01822 ^@ http://purl.uniprot.org/uniprot/A8WQQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms chloride channels.|||Membrane http://togogenome.org/gene/6238:CBG_20397 ^@ http://purl.uniprot.org/uniprot/A8XXP4 ^@ Similarity ^@ Belongs to the rtf2 family. http://togogenome.org/gene/6238:CBG_14607 ^@ http://purl.uniprot.org/uniprot/A8XKA2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M2 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/6238:CBG_15296 ^@ http://purl.uniprot.org/uniprot/A8XLV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMG-CoA reductase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/6238:CBG_13259 ^@ http://purl.uniprot.org/uniprot/A8XHF1 ^@ Similarity ^@ Belongs to the STEEP1 family. http://togogenome.org/gene/6238:CBG_08575 ^@ http://purl.uniprot.org/uniprot/A8X733 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/6238:CBG_12264 ^@ http://purl.uniprot.org/uniprot/A8XF45 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/6238:CBG_03807 ^@ http://purl.uniprot.org/uniprot/A8WWS6 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/6238:CBG_19656 ^@ http://purl.uniprot.org/uniprot/A8XW44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U1 small nuclear ribonucleoprotein C family.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Nucleus|||U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. http://togogenome.org/gene/6238:CBG_02460 ^@ http://purl.uniprot.org/uniprot/A8WU98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS5 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/6238:CBG_15632 ^@ http://purl.uniprot.org/uniprot/A8XMF2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. Has a role in the exit from M phase during early mitotic cell division. More specifically, thought to act by the degrading B-type cyclins that causes breakdown of nuclear envelope and exit mitosis (By similarity).|||Forms a homohexamer that can probably bind six kinase subunits. Interacts with cdk-1 (By similarity).|||Nucleus http://togogenome.org/gene/6238:CBG_20417 ^@ http://purl.uniprot.org/uniprot/A8XXR1 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/6238:CBG_22764 ^@ http://purl.uniprot.org/uniprot/A8Y2U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/6238:CBG_14945 ^@ http://purl.uniprot.org/uniprot/A8XL25 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. Three molecules of crn-1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Mitochondrion|||Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.|||nucleolus|||nucleoplasm http://togogenome.org/gene/6238:CBG_14224 ^@ http://purl.uniprot.org/uniprot/A8XJJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/6238:CBG_03312 ^@ http://purl.uniprot.org/uniprot/A8WSB5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/6238:CBG_13093 ^@ http://purl.uniprot.org/uniprot/A8XH26 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srd family. http://togogenome.org/gene/6238:CBG_03818 ^@ http://purl.uniprot.org/uniprot/A8WWT8 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_05038 ^@ http://purl.uniprot.org/uniprot/A8WZ14 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_19056 ^@ http://purl.uniprot.org/uniprot/A8XUN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sre family.|||Membrane http://togogenome.org/gene/6238:CBG_04607 ^@ http://purl.uniprot.org/uniprot/A8WY17 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/6238:CBG_13750 ^@ http://purl.uniprot.org/uniprot/A8XIL6 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srd family. http://togogenome.org/gene/6238:CBG_23370 ^@ http://purl.uniprot.org/uniprot/A8Y430 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/6238:CBG_20832 ^@ http://purl.uniprot.org/uniprot/A8XYQ9 ^@ Similarity ^@ Belongs to the SKI family. http://togogenome.org/gene/6238:CBG_14798 ^@ http://purl.uniprot.org/uniprot/G2J6V0 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/6238:CBG_01356 ^@ http://purl.uniprot.org/uniprot/A8WQ81 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/6238:CBG_21202 ^@ http://purl.uniprot.org/uniprot/A8XZM0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6238:CBG_13514 ^@ http://purl.uniprot.org/uniprot/A8XI28 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_14267 ^@ http://purl.uniprot.org/uniprot/A8XJM7 ^@ Function|||Similarity ^@ Belongs to the pyridoxamine 5'-phosphate oxidase family.|||Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). http://togogenome.org/gene/6238:CBG_05292 ^@ http://purl.uniprot.org/uniprot/A8WZJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/6238:CBG_04748 ^@ http://purl.uniprot.org/uniprot/A8WYD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3A3 family.|||Nucleus http://togogenome.org/gene/6238:CBG_14606 ^@ http://purl.uniprot.org/uniprot/A8XKA1 ^@ Similarity|||Subunit ^@ Belongs to the type II pantothenate kinase family.|||Homodimer. Interacts with PKM.|||In the N-terminal section; belongs to the type II pantothenate kinase family. http://togogenome.org/gene/6238:CBG_11542 ^@ http://purl.uniprot.org/uniprot/A8XDG1 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/6238:CBG_20785 ^@ http://purl.uniprot.org/uniprot/A8XYL9 ^@ Similarity ^@ Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily. http://togogenome.org/gene/6238:CBG_08181 ^@ http://purl.uniprot.org/uniprot/A8X604 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/6238:CBG_00928 ^@ http://purl.uniprot.org/uniprot/A8WPA7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SEC5 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||Component of the exocyst complex. http://togogenome.org/gene/6238:CBG_06263 ^@ http://purl.uniprot.org/uniprot/A8X0I2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/6238:CBG_05572 ^@ http://purl.uniprot.org/uniprot/A8X064 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/6238:CBG_04391 ^@ http://purl.uniprot.org/uniprot/A8WXF6 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.|||Ca(2+)/calmodulin binding removes an autoinhibitory regulatory segment located C-terminal to the kinase domain. This releases the catalytic activity of the enzyme and makes accessible a regulatory residue Thr-284. Phosphorylation of Thr-284 by another kinase domain within the oligomeric holoenzyme keeps CaMKII active in the absence of Ca(2+)/calmodulin by preventing the rebinding of the regulatory segment to the kinase domain and by increasing the affinity of calmodulin for the enzyme. Can respond to high-frequency Ca(2+) pulses to become Ca(2+) independent (By similarity).|||Cytoplasm|||Dodecamer. Subunits are tightly packed around a central ring-shaped scaffold with extensive contacts between the regulatory segment of one kinase and the catalytic domain of another enabling cooperative activation of a subunit by the adjacent molecule. Interacts with and phosphorylates daf-16; the interaction promotes daf-16 nuclear localization. Interacts with egl-2 and tir-1. Interacts with nsy-1.|||Perikaryon|||Role in locomotion and neuronal cell fate specification. Required for the regulation of synaptic density, egg laying, defecation, and meiotic maturation. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Regulates the synaptic trafficking of glr-1. Bidirectional modulator of neurotransmitter release with negative modulatory effects mainly mediated via slo-1 activation. May suppress the functional response to an internal pacemaker, perhaps by modulating the activity of the IP3 receptor (By similarity).|||axon http://togogenome.org/gene/6238:CBG_04029 ^@ http://purl.uniprot.org/uniprot/A8WW14 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/6238:CBG_18980 ^@ http://purl.uniprot.org/uniprot/A8XUH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_19506 ^@ http://purl.uniprot.org/uniprot/A8XVS0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_07468 ^@ http://purl.uniprot.org/uniprot/G2J6L3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_21465 ^@ http://purl.uniprot.org/uniprot/A8Y039 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/6238:CBG_09818 ^@ http://purl.uniprot.org/uniprot/A8X9Q3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTPA-type PPIase family.|||Cytoplasm|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/6238:CBG_05999 ^@ http://purl.uniprot.org/uniprot/A8X153 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_18418 ^@ http://purl.uniprot.org/uniprot/A8XTA0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_19889 ^@ http://purl.uniprot.org/uniprot/A8XWN7 ^@ Similarity ^@ Belongs to the peptidase M67A family. CSN5 subfamily. http://togogenome.org/gene/6238:CBG_06744 ^@ http://purl.uniprot.org/uniprot/A8X2Z9 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_10351 ^@ http://purl.uniprot.org/uniprot/A8XB06 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_06027 ^@ http://purl.uniprot.org/uniprot/A8X126 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/6238:CBG_03614 ^@ http://purl.uniprot.org/uniprot/A8WVG4 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/6238:CBG_03324 ^@ http://purl.uniprot.org/uniprot/A8WUS4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/6238:CBG_11518 ^@ http://purl.uniprot.org/uniprot/A8XCT2 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/6238:CBG_15207 ^@ http://purl.uniprot.org/uniprot/A8XLN9 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/6238:CBG_21241 ^@ http://purl.uniprot.org/uniprot/A8XZI9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC25 family.|||Endomembrane system|||Interacts (via cytoplasmic region) with ILK. http://togogenome.org/gene/6238:CBG_18316 ^@ http://purl.uniprot.org/uniprot/Q60YA8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pseudouridine synthase TruB family.|||Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs).|||Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).|||nucleolus http://togogenome.org/gene/6238:CBG_03134 ^@ http://purl.uniprot.org/uniprot/A8WSQ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the aldehyde dehydrogenase family.|||Homotetramer.|||Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. http://togogenome.org/gene/6238:CBG_14296 ^@ http://purl.uniprot.org/uniprot/A8XJP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_09649 ^@ http://purl.uniprot.org/uniprot/A8X8K1 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srg family. http://togogenome.org/gene/6238:CBG_12876 ^@ http://purl.uniprot.org/uniprot/A8XFS9 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/6238:CBG_01103 ^@ http://purl.uniprot.org/uniprot/A8WPK2 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6238:CBG_12920 ^@ http://purl.uniprot.org/uniprot/A8XGP0 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/6238:CBG_09654 ^@ http://purl.uniprot.org/uniprot/Q61JS7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM50 family.|||Component of the TIM23 complex at least composed of tim-23, tim-17 and tim-50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_23733 ^@ http://purl.uniprot.org/uniprot/A8WJ61 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/6238:CBG_05261 ^@ http://purl.uniprot.org/uniprot/A8WZH6 ^@ Function|||Similarity ^@ Belongs to the SKP1 family.|||Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. http://togogenome.org/gene/6238:CBG_04296 ^@ http://purl.uniprot.org/uniprot/A8WX66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/6238:CBG_24150 ^@ http://purl.uniprot.org/uniprot/A8WK31 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/6238:CBG_01052 ^@ http://purl.uniprot.org/uniprot/A8WP05 ^@ Similarity ^@ Belongs to the Mo25 family. http://togogenome.org/gene/6238:CBG_21702 ^@ http://purl.uniprot.org/uniprot/A8Y0P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase K family.|||Membrane http://togogenome.org/gene/6238:CBG_08480 ^@ http://purl.uniprot.org/uniprot/A8X6N5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/6238:CBG_04946 ^@ http://purl.uniprot.org/uniprot/A8WYV4 ^@ Similarity ^@ Belongs to the glycosyltransferase 92 family. http://togogenome.org/gene/6238:CBG_03988 ^@ http://purl.uniprot.org/uniprot/A8WVX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/6238:CBG_14485 ^@ http://purl.uniprot.org/uniprot/A8XK15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_02943 ^@ http://purl.uniprot.org/uniprot/A8WT57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/6238:CBG_00836 ^@ http://purl.uniprot.org/uniprot/A8WNY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/6238:CBG_20807 ^@ http://purl.uniprot.org/uniprot/A8XYN7 ^@ Function|||Similarity ^@ Belongs to the catalase family.|||Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. http://togogenome.org/gene/6238:CBG_02108 ^@ http://purl.uniprot.org/uniprot/A8WS01 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_22149 ^@ http://purl.uniprot.org/uniprot/A8Y1N2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/6238:CBG_16825 ^@ http://purl.uniprot.org/uniprot/C0HLB5|||http://purl.uniprot.org/uniprot/C0HLB6 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Involved in necrotic cell death. Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad. This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization. The introduction of sperm triggers V-ATPase accumulation in proximal oocytes and induces lysosomal acidification which leads to engulfing of protein aggregates by lysosomes and subsequent clearance of the aggregates. Lysosomal acidification also leads to changes in mitochondrial morphology and function. Mitochondria in distal immature oocytes are fragmented, produce high levels of reactive oxygen species (ROS) and have high membrane potential, indicative of metabolic inactivity. In contrast, mitochondria in proximal mature oocytes are tubular with lower ROS levels and membrane potential, indicative of an active metabolic state required for aggregate mobilization before clearance (By similarity).|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity).|||Vha-11 and vha-3 are transcribed on a dicistronic transcript where vha-3 is the upstream transcript and vha-11 the downstream. http://togogenome.org/gene/6238:CBG_12204 ^@ http://purl.uniprot.org/uniprot/Q61E63 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although related to the peptidase M24 family, this protein lacks conserved active site residues suggesting that it may lack peptidase activity.|||Belongs to the peptidase M24 family. SPT16 subfamily.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).|||Component of the FACT complex, a stable heterodimer of spt-16 and hmg-3 or hmg-4.|||Nucleus http://togogenome.org/gene/6238:CBG_12778 ^@ http://purl.uniprot.org/uniprot/A8XGJ6 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/6238:CBG_10832 ^@ http://purl.uniprot.org/uniprot/A8XBW6 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/6238:CBG_08781 ^@ http://purl.uniprot.org/uniprot/A8X7D7 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_12504 ^@ http://purl.uniprot.org/uniprot/A8XFX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Mitochondrion http://togogenome.org/gene/6238:CBG_01388 ^@ http://purl.uniprot.org/uniprot/A8WQA7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_03716 ^@ http://purl.uniprot.org/uniprot/A8WWJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/6238:CBG_17053 ^@ http://purl.uniprot.org/uniprot/A8XQC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic10 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_23511 ^@ http://purl.uniprot.org/uniprot/A8Y3R2 ^@ Similarity ^@ Belongs to the P-Pant transferase superfamily. AcpS family. http://togogenome.org/gene/6238:CBG_18573 ^@ http://purl.uniprot.org/uniprot/A8XTM0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_01269 ^@ http://purl.uniprot.org/uniprot/A8WQ01 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_21902 ^@ http://purl.uniprot.org/uniprot/A8Y197 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Required for positioning of the mitotic spindle (By similarity).|||Cytoplasm|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/6238:CBG_03768 ^@ http://purl.uniprot.org/uniprot/A8WWP0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/6238:CBG_09044 ^@ http://purl.uniprot.org/uniprot/A8X7Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_14230 ^@ http://purl.uniprot.org/uniprot/A8XJK0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6238:CBG_02538 ^@ http://purl.uniprot.org/uniprot/A8WU33 ^@ Similarity ^@ Belongs to the frataxin family. http://togogenome.org/gene/6238:CBG_08882 ^@ http://purl.uniprot.org/uniprot/A8X7L9 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/6238:CBG_03401 ^@ http://purl.uniprot.org/uniprot/A8WUZ0 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/6238:CBG_08353 ^@ http://purl.uniprot.org/uniprot/A8X6D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein srb family.|||Membrane http://togogenome.org/gene/6238:CBG_17617 ^@ http://purl.uniprot.org/uniprot/A8XRP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/6238:CBG_14708 ^@ http://purl.uniprot.org/uniprot/A8XKI1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6238:CBG_16653 ^@ http://purl.uniprot.org/uniprot/A8XP85 ^@ Similarity ^@ Belongs to the patched family. http://togogenome.org/gene/6238:CBG_15187 ^@ http://purl.uniprot.org/uniprot/A8XLQ9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/6238:CBG_03860 ^@ http://purl.uniprot.org/uniprot/A8WWX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_22042 ^@ http://purl.uniprot.org/uniprot/A8Y1E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_11100 ^@ http://purl.uniprot.org/uniprot/A8XCE6 ^@ Similarity ^@ Belongs to the TTC19 family. http://togogenome.org/gene/6238:CBG_19292 ^@ http://purl.uniprot.org/uniprot/A8XVA0 ^@ Similarity ^@ Belongs to the acetyltransferase family. GNA1 subfamily. http://togogenome.org/gene/6238:CBG_06368 ^@ http://purl.uniprot.org/uniprot/A8X229 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/6238:CBG_06644 ^@ http://purl.uniprot.org/uniprot/A8X2R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZFPL1 family.|||Membrane http://togogenome.org/gene/6238:CBG_09278 ^@ http://purl.uniprot.org/uniprot/A8X9G8 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/6238:CBG_22549 ^@ http://purl.uniprot.org/uniprot/A8Y2J2 ^@ Similarity ^@ Belongs to the parvin family. http://togogenome.org/gene/6238:CBG_18057 ^@ http://purl.uniprot.org/uniprot/A8XSX9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/6238:CBG_04618 ^@ http://purl.uniprot.org/uniprot/A8WY27 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.|||nucleolus http://togogenome.org/gene/6238:CBG_06566 ^@ http://purl.uniprot.org/uniprot/A8X2J7 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/6238:CBG_05328 ^@ http://purl.uniprot.org/uniprot/A8WZL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTX family.|||Nucleus http://togogenome.org/gene/6238:CBG_12873 ^@ http://purl.uniprot.org/uniprot/A8XFS6 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/6238:CBG_21759 ^@ http://purl.uniprot.org/uniprot/A8Y0J9 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/6238:CBG_22273 ^@ http://purl.uniprot.org/uniprot/A8Y1Y4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/6238:CBG_04528 ^@ http://purl.uniprot.org/uniprot/A8WXN8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_09160 ^@ http://purl.uniprot.org/uniprot/A8X878 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_19129 ^@ http://purl.uniprot.org/uniprot/A8XUW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/6238:CBG_23417 ^@ http://purl.uniprot.org/uniprot/A8Y3Z0 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_13964 ^@ http://purl.uniprot.org/uniprot/A8XIY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG3 family.|||Cytoplasm http://togogenome.org/gene/6238:CBG_12253 ^@ http://purl.uniprot.org/uniprot/Q61E22 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UFM1 family.|||Interacts with odr-8; leading to deufmylation.|||Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer (By similarity). The so-called ufmylation requires the ufm-1-activating E1 enzyme uba-5, the ufm-1-conjugating E2 enzyme ufc-1, and probably the ufm-1-ligase E3 enzyme ufl-1 (By similarity). http://togogenome.org/gene/6238:CBG_02932 ^@ http://purl.uniprot.org/uniprot/A8WT67 ^@ Similarity ^@ Belongs to the GTR/RAG GTP-binding protein family. http://togogenome.org/gene/6238:CBG_12708 ^@ http://purl.uniprot.org/uniprot/A8XGD9 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/6238:CBG_03823 ^@ http://purl.uniprot.org/uniprot/A8WWU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/6238:CBG_12969 ^@ http://purl.uniprot.org/uniprot/A8XGS7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_09664 ^@ http://purl.uniprot.org/uniprot/A8X8I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/6238:CBG_12292 ^@ http://purl.uniprot.org/uniprot/G2J6R2 ^@ Similarity ^@ Belongs to the GST superfamily. Omega family. http://togogenome.org/gene/6238:CBG_04606 ^@ http://purl.uniprot.org/uniprot/A8WY16 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/6238:CBG_08840 ^@ http://purl.uniprot.org/uniprot/A8X7I3 ^@ Similarity ^@ Belongs to the annexin family. http://togogenome.org/gene/6238:CBG_23282 ^@ http://purl.uniprot.org/uniprot/A8Y4A1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_23799 ^@ http://purl.uniprot.org/uniprot/A8WJB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BBS5 family.|||Membrane|||centriolar satellite|||cilium membrane http://togogenome.org/gene/6238:CBG_22507 ^@ http://purl.uniprot.org/uniprot/A8Y2F4 ^@ Similarity ^@ Belongs to the selenoprotein M/F family. http://togogenome.org/gene/6238:CBG_23475 ^@ http://purl.uniprot.org/uniprot/A8Y3U1 ^@ Similarity ^@ Belongs to the mitoguardin family. http://togogenome.org/gene/6238:CBG_19334 ^@ http://purl.uniprot.org/uniprot/A8XVD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-54 family.|||Nucleus http://togogenome.org/gene/6238:CBG_20661 ^@ http://purl.uniprot.org/uniprot/A8XYB1 ^@ Function|||Similarity ^@ Belongs to the diphosphomevalonate decarboxylase family.|||Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. http://togogenome.org/gene/6238:CBG_14670 ^@ http://purl.uniprot.org/uniprot/A8XKF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Membrane http://togogenome.org/gene/6238:CBG_12149 ^@ http://purl.uniprot.org/uniprot/A8XEV3 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/6238:CBG_11896 ^@ http://purl.uniprot.org/uniprot/A8XE93 ^@ Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/6238:CBG_23184 ^@ http://purl.uniprot.org/uniprot/A8Y4I0 ^@ Similarity ^@ Belongs to the PP1 inhibitor family. http://togogenome.org/gene/6238:CBG_08364 ^@ http://purl.uniprot.org/uniprot/A8X6E0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_16150 ^@ http://purl.uniprot.org/uniprot/A8XP04 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. http://togogenome.org/gene/6238:CBG_22497 ^@ http://purl.uniprot.org/uniprot/A8Y2E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Nucleus http://togogenome.org/gene/6238:CBG_22911 ^@ http://purl.uniprot.org/uniprot/A8Y3C5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_13600 ^@ http://purl.uniprot.org/uniprot/A8XIA0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/6238:CBG_04461 ^@ http://purl.uniprot.org/uniprot/A8WXM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/6238:CBG_19169 ^@ http://purl.uniprot.org/uniprot/A8XUZ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_16080 ^@ http://purl.uniprot.org/uniprot/A8XN54 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/6238:CBG_11475 ^@ http://purl.uniprot.org/uniprot/Q61FW2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Probable component of the SCF(sel-10) E3 ubiquitin-protein ligase complex which includes skr-1 and F-box domain-containing protein sel-10 as a substrate recognition component. Interacts with fem-1, fem-2, and fem-3. Interacts with the intracellular domain of glp-1 and sel-12. Interacts with lin-12. Interacts with skr-1. Interacts with zyg-1.|||Probable substrate recognition component of SCF (SKP1-CUL-F-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates synapse elimination in early development in the motor neuron HSNL. Cell autonomous negative regulator of lin-12/Notch-mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis. May target the intracellular domains of lin-12/Notch proteins for ubiquitin-dependent degradation. Involved in sex determination by promoting female development. Potential regulator of presenilin. May have a role in egg laying. Regulates zyg-1 levels (possibly redundantly with lin-23) to control centrosome duplication during mitosis. Negatively regulates lin-45 activity and protein stability, probably by targeting it for ubiquitination and proteasomal degradation.|||axon http://togogenome.org/gene/6238:CBG_20259 ^@ http://purl.uniprot.org/uniprot/A8XXE0 ^@ Similarity|||Subunit ^@ Belongs to the ODC antizyme family.|||Interacts with ODC1 and thereby sterically blocks ODC homodimerization. http://togogenome.org/gene/6238:CBG_20477 ^@ http://purl.uniprot.org/uniprot/A8XXW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS6 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_10567 ^@ http://purl.uniprot.org/uniprot/A8XBC5 ^@ Similarity ^@ Belongs to the ATG101 family. http://togogenome.org/gene/6238:CBG_15881 ^@ http://purl.uniprot.org/uniprot/A8XMZ8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_03308 ^@ http://purl.uniprot.org/uniprot/Q61Z20 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 10 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/6238:CBG_17727 ^@ http://purl.uniprot.org/uniprot/A8XRF4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/6238:CBG_01548 ^@ http://purl.uniprot.org/uniprot/A8WRE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I NDUFB11 subunit family.|||Membrane http://togogenome.org/gene/6238:CBG_19767 ^@ http://purl.uniprot.org/uniprot/A8XWD1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex (also known as MINOS or MitOS complex).|||Belongs to the metaxin family.|||Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity).|||Mitochondrion outer membrane http://togogenome.org/gene/6238:CBG_06762 ^@ http://purl.uniprot.org/uniprot/A8X309 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srg family. http://togogenome.org/gene/6238:CBG_10000 ^@ http://purl.uniprot.org/uniprot/C0HLB5|||http://purl.uniprot.org/uniprot/C0HLB6 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Involved in necrotic cell death. Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad. This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization. The introduction of sperm triggers V-ATPase accumulation in proximal oocytes and induces lysosomal acidification which leads to engulfing of protein aggregates by lysosomes and subsequent clearance of the aggregates. Lysosomal acidification also leads to changes in mitochondrial morphology and function. Mitochondria in distal immature oocytes are fragmented, produce high levels of reactive oxygen species (ROS) and have high membrane potential, indicative of metabolic inactivity. In contrast, mitochondria in proximal mature oocytes are tubular with lower ROS levels and membrane potential, indicative of an active metabolic state required for aggregate mobilization before clearance (By similarity).|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity).|||Vha-11 and vha-3 are transcribed on a dicistronic transcript where vha-3 is the upstream transcript and vha-11 the downstream. http://togogenome.org/gene/6238:CBG_08570 ^@ http://purl.uniprot.org/uniprot/A8X738 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL49 family.|||Mitochondrion http://togogenome.org/gene/6238:CBG_06259 ^@ http://purl.uniprot.org/uniprot/A8X0I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sre family.|||Membrane http://togogenome.org/gene/6238:CBG_13233 ^@ http://purl.uniprot.org/uniprot/G2J6X7 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/6238:CBG_11183 ^@ http://purl.uniprot.org/uniprot/A8XCM9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) ions per subunit.|||Converts sphingomyelin to ceramide.|||Secreted http://togogenome.org/gene/6238:CBG_13509 ^@ http://purl.uniprot.org/uniprot/A8XI23 ^@ Similarity ^@ Belongs to the HSBP1 family. http://togogenome.org/gene/6238:CBG_17041 ^@ http://purl.uniprot.org/uniprot/A8XQB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unkempt family.|||Cytoplasm http://togogenome.org/gene/6238:CBG_21054 ^@ http://purl.uniprot.org/uniprot/A8XZA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM144 family.|||Membrane http://togogenome.org/gene/6238:CBG_10109 ^@ http://purl.uniprot.org/uniprot/A8XAE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FARP (FMRFamide related peptide) family.|||Secreted http://togogenome.org/gene/6238:CBG_11742 ^@ http://purl.uniprot.org/uniprot/A8XDU2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/6238:CBG_05575 ^@ http://purl.uniprot.org/uniprot/A8X067 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_05212 ^@ http://purl.uniprot.org/uniprot/A8WZE4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/6238:CBG_03777 ^@ http://purl.uniprot.org/uniprot/A8WWP9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_10413 ^@ http://purl.uniprot.org/uniprot/A8XB54 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/6238:CBG_06021 ^@ http://purl.uniprot.org/uniprot/Q61SU8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Has a role in gonadogenesis (By similarity).|||Cytoplasm|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/6238:CBG_11388 ^@ http://purl.uniprot.org/uniprot/A8XD48 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/6238:CBG_15298 ^@ http://purl.uniprot.org/uniprot/A8XLW0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GOSR1 family.|||Component of several multiprotein Golgi SNARE complexes.|||Golgi apparatus membrane|||Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. Cooperates with ykt-6 for proper expression of Golgi-resident proteins. Required along with ykt-6 for normal embryonic development, seam cell division or differentiation, and ray formation (By similarity). http://togogenome.org/gene/6238:CBG_08086 ^@ http://purl.uniprot.org/uniprot/A8X5S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/6238:CBG_10082 ^@ http://purl.uniprot.org/uniprot/A8XAC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family.|||Cytoplasm|||Glycosyltransferase with a proposed role in glycosphingolipid biosynthesis. Involved in susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-2 and bre-4. Involved in resistance to the nematotoxic C.cinerea galectin Cgl2. Has a role in determining brood size (By similarity). http://togogenome.org/gene/6238:CBG_03216 ^@ http://purl.uniprot.org/uniprot/A8WSJ2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_21868 ^@ http://purl.uniprot.org/uniprot/A8Y108 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/6238:CBG_05414 ^@ http://purl.uniprot.org/uniprot/A8WZT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms chloride channels.|||Membrane http://togogenome.org/gene/6238:CBG_12037 ^@ http://purl.uniprot.org/uniprot/A8XEE7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. http://togogenome.org/gene/6238:CBG_13574 ^@ http://purl.uniprot.org/uniprot/A8XI78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_03179 ^@ http://purl.uniprot.org/uniprot/A8WSL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DXO/Dom3Z family.|||Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.|||Nucleus http://togogenome.org/gene/6238:CBG_18191 ^@ http://purl.uniprot.org/uniprot/A8XT83 ^@ Similarity ^@ Belongs to the Cob(I)alamin adenosyltransferase family. http://togogenome.org/gene/6238:CBG_23842 ^@ http://purl.uniprot.org/uniprot/A8WJF2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Component of nuclear RNase P and RNase MRP.|||Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||nucleolus http://togogenome.org/gene/6238:CBG_07415 ^@ http://purl.uniprot.org/uniprot/A8X4T8 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_08333 ^@ http://purl.uniprot.org/uniprot/A8X6B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_23911 ^@ http://purl.uniprot.org/uniprot/A8WJK2 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/6238:CBG_21867 ^@ http://purl.uniprot.org/uniprot/A8Y107 ^@ Similarity ^@ Belongs to the eukaryotic ATPase epsilon family. http://togogenome.org/gene/6238:CBG_16594 ^@ http://purl.uniprot.org/uniprot/A8XPJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_09846 ^@ http://purl.uniprot.org/uniprot/A8X9S8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_00031 ^@ http://purl.uniprot.org/uniprot/A8WM62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_01029 ^@ http://purl.uniprot.org/uniprot/A8WP26 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_23747 ^@ http://purl.uniprot.org/uniprot/A8WJ72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/6238:CBG_08367 ^@ http://purl.uniprot.org/uniprot/A8X6E3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_20620 ^@ http://purl.uniprot.org/uniprot/A8XY80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_20703 ^@ http://purl.uniprot.org/uniprot/A8XYF1 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/6238:CBG_08408 ^@ http://purl.uniprot.org/uniprot/A8X6H5 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_18074 ^@ http://purl.uniprot.org/uniprot/A8XSZ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBM8A family.|||Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.|||Cytoplasm|||Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.|||Nucleus|||Nucleus speckle http://togogenome.org/gene/6238:CBG_01387 ^@ http://purl.uniprot.org/uniprot/A8WQA6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_20993 ^@ http://purl.uniprot.org/uniprot/A8XZ46 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_05724 ^@ http://purl.uniprot.org/uniprot/A8X1S9 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/6238:CBG_15267 ^@ http://purl.uniprot.org/uniprot/O61644 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/6238:CBG_05939 ^@ http://purl.uniprot.org/uniprot/A8X1A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FARP (FMRFamide related peptide) family.|||Secreted http://togogenome.org/gene/6238:CBG_09576 ^@ http://purl.uniprot.org/uniprot/A8X8S1 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_17637 ^@ http://purl.uniprot.org/uniprot/A8XRM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Membrane http://togogenome.org/gene/6238:CBG_18187 ^@ http://purl.uniprot.org/uniprot/A8XT79 ^@ Similarity ^@ Belongs to the GET4 family. http://togogenome.org/gene/6238:CBG_20483 ^@ http://purl.uniprot.org/uniprot/A8XXW7 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/6238:CBG_01585 ^@ http://purl.uniprot.org/uniprot/A8WRB3 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/6238:CBG_20655 ^@ http://purl.uniprot.org/uniprot/A8XYA9 ^@ Similarity ^@ Belongs to the RRP12 family. http://togogenome.org/gene/6238:CBG_02375 ^@ http://purl.uniprot.org/uniprot/A8WUH0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MESD family.|||Belongs to the nematode receptor-like protein srg family.|||Endoplasmic reticulum|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_17632 ^@ http://purl.uniprot.org/uniprot/A8XRN3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 6-phosphogluconate dehydrogenase family.|||Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.|||Homodimer. http://togogenome.org/gene/6238:CBG_04223 ^@ http://purl.uniprot.org/uniprot/A8WWG3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. http://togogenome.org/gene/6238:CBG_19793 ^@ http://purl.uniprot.org/uniprot/H8WHA8|||http://purl.uniprot.org/uniprot/Q60UW4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||Cytoplasm|||The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.|||Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. Involved in muscle actin filament organization and muscle arm extension and morphology. Also has a role in male mating behavior by regulating the copulatory spicules. Binds to F-actin (By similarity). http://togogenome.org/gene/6238:CBG_06130 ^@ http://purl.uniprot.org/uniprot/A8X0U4 ^@ Similarity ^@ Belongs to the DNA polymerase delta/II small subunit family. http://togogenome.org/gene/6238:CBG_21209 ^@ http://purl.uniprot.org/uniprot/A8XZL4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/6238:CBG_02222 ^@ http://purl.uniprot.org/uniprot/A8WS88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INCENP family.|||Nucleus|||spindle http://togogenome.org/gene/6238:CBG_12095 ^@ http://purl.uniprot.org/uniprot/A8XEJ6 ^@ Similarity ^@ Belongs to the CAP family. http://togogenome.org/gene/6238:CBG_21516 ^@ http://purl.uniprot.org/uniprot/A8Y0A6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/6238:CBG_05068 ^@ http://purl.uniprot.org/uniprot/A8WZ37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Membrane http://togogenome.org/gene/6238:CBG_00043 ^@ http://purl.uniprot.org/uniprot/A8WM72 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_04174 ^@ http://purl.uniprot.org/uniprot/A8WWC3 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/6238:CBG_18258 ^@ http://purl.uniprot.org/uniprot/A8XS97 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_17162 ^@ http://purl.uniprot.org/uniprot/Q611C8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||Endoplasmic reticulum membrane|||Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi (By similarity). http://togogenome.org/gene/6238:CBG_04204 ^@ http://purl.uniprot.org/uniprot/A8WWF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_13066 ^@ http://purl.uniprot.org/uniprot/A8XH01 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/6238:CBG_02877 ^@ http://purl.uniprot.org/uniprot/G2J6F0 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_10950 ^@ http://purl.uniprot.org/uniprot/A8XBX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/6238:CBG_18578 ^@ http://purl.uniprot.org/uniprot/A8XTM4 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/6238:CBG_09575 ^@ http://purl.uniprot.org/uniprot/A8X8S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/6238:CBG_16767 ^@ http://purl.uniprot.org/uniprot/A8XPS2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/6238:CBG_09167 ^@ http://purl.uniprot.org/uniprot/Q9GZ04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/6238:CBG_18572 ^@ http://purl.uniprot.org/uniprot/A8XTL9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_09577 ^@ http://purl.uniprot.org/uniprot/A8X8S0 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_04136 ^@ http://purl.uniprot.org/uniprot/A8WVN0 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/6238:CBG_12225 ^@ http://purl.uniprot.org/uniprot/A8XEY3 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/6238:CBG_20666 ^@ http://purl.uniprot.org/uniprot/A8XYB6 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/6238:CBG_12178 ^@ http://purl.uniprot.org/uniprot/A8XF23 ^@ Function|||Similarity ^@ Belongs to the COG3 family.|||Belongs to the EXO70 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||Involved in ER-Golgi transport. http://togogenome.org/gene/6238:CBG_22036 ^@ http://purl.uniprot.org/uniprot/A8Y1E0 ^@ Function|||Similarity ^@ Belongs to the glutaredoxin family.|||Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. http://togogenome.org/gene/6238:CBG_16005 ^@ http://purl.uniprot.org/uniprot/A8XNA7 ^@ Domain|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/6238:CBG_01362 ^@ http://purl.uniprot.org/uniprot/A8WQ87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/6238:CBG_10857 ^@ http://purl.uniprot.org/uniprot/A8XC56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_01337 ^@ http://purl.uniprot.org/uniprot/A8WQ62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/6238:CBG_12386 ^@ http://purl.uniprot.org/uniprot/A8XFB2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/6238:CBG_15797 ^@ http://purl.uniprot.org/uniprot/A8XMT8 ^@ Similarity ^@ Belongs to the GST superfamily. Omega family. http://togogenome.org/gene/6238:CBG_13324 ^@ http://purl.uniprot.org/uniprot/A8XHK9 ^@ Similarity ^@ Belongs to the polyprenol kinase family. http://togogenome.org/gene/6238:CBG_18982 ^@ http://purl.uniprot.org/uniprot/A8XUH7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_13312 ^@ http://purl.uniprot.org/uniprot/A8XHJ7 ^@ Function|||Similarity ^@ Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis. http://togogenome.org/gene/6238:CBG_03169 ^@ http://purl.uniprot.org/uniprot/A8WSM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/6238:CBG_17658 ^@ http://purl.uniprot.org/uniprot/A8XRL1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/6238:CBG_06794 ^@ http://purl.uniprot.org/uniprot/A8X333 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_02633 ^@ http://purl.uniprot.org/uniprot/A8WTV5 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/6238:CBG_10030 ^@ http://purl.uniprot.org/uniprot/A8XA78 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/6238:CBG_11996 ^@ http://purl.uniprot.org/uniprot/A8XEB0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Structural component of the gap junctions.|||gap junction http://togogenome.org/gene/6238:CBG_06071 ^@ http://purl.uniprot.org/uniprot/A8X0Z1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Appears to play a non-essential role (By similarity).|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/6238:CBG_12233 ^@ http://purl.uniprot.org/uniprot/A8XEX6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_22301 ^@ http://purl.uniprot.org/uniprot/G2J6V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/6238:CBG_09155 ^@ http://purl.uniprot.org/uniprot/A8X874 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_03443 ^@ http://purl.uniprot.org/uniprot/Q61YQ1 ^@ Cofactor|||PTM|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Binds 2 Zn(2+) ions per subunit.|||Carboxylation allows a single lysine to coordinate two zinc ions.|||Homotetramer. http://togogenome.org/gene/6238:CBG_12314 ^@ http://purl.uniprot.org/uniprot/A8XFJ3 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/6238:CBG_14988 ^@ http://purl.uniprot.org/uniprot/A8XL58 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_12733 ^@ http://purl.uniprot.org/uniprot/A8XGG3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/6238:CBG_17475 ^@ http://purl.uniprot.org/uniprot/A8XR41 ^@ Caution|||Similarity ^@ Belongs to the nematode receptor-like protein srg family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_18635 ^@ http://purl.uniprot.org/uniprot/A8XTS1 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6238:CBG_06696 ^@ http://purl.uniprot.org/uniprot/A8X2V9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I LYR family. SDHAF3 subfamily.|||Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. http://togogenome.org/gene/6238:CBG_24493 ^@ http://purl.uniprot.org/uniprot/A8WKU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMN family.|||Cytoplasm|||gem http://togogenome.org/gene/6238:CBG_02744 ^@ http://purl.uniprot.org/uniprot/A8WTL5 ^@ Similarity ^@ Belongs to the NUP186/NUP192/NUP205 family. http://togogenome.org/gene/6238:CBG_17638 ^@ http://purl.uniprot.org/uniprot/A8XRM8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_23335 ^@ http://purl.uniprot.org/uniprot/A0T399 ^@ Subcellular Location Annotation|||Subunit ^@ Heterodimer of burs and pburs.|||Secreted http://togogenome.org/gene/6238:CBG_09798 ^@ http://purl.uniprot.org/uniprot/A8X9N5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_03318 ^@ http://purl.uniprot.org/uniprot/A8WUR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCR4/nocturin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/6238:CBG_20102 ^@ http://purl.uniprot.org/uniprot/A8XX35 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_11921 ^@ http://purl.uniprot.org/uniprot/A8XEL5 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_09488 ^@ http://purl.uniprot.org/uniprot/A8X902 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_12412 ^@ http://purl.uniprot.org/uniprot/A8XFD4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/6238:CBG_20992 ^@ http://purl.uniprot.org/uniprot/A8XZ45 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_01248 ^@ http://purl.uniprot.org/uniprot/A8WPY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_03802 ^@ http://purl.uniprot.org/uniprot/A8WWS1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_19421 ^@ http://purl.uniprot.org/uniprot/A8XVK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Stoned B family.|||Cytoplasm http://togogenome.org/gene/6238:CBG_11066 ^@ http://purl.uniprot.org/uniprot/A8XCB8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_16759 ^@ http://purl.uniprot.org/uniprot/A8XPR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||cytoskeleton http://togogenome.org/gene/6238:CBG_03392 ^@ http://purl.uniprot.org/uniprot/A8WUY2 ^@ Similarity ^@ In the C-terminal section; belongs to the NAD synthetase family. http://togogenome.org/gene/6238:CBG_22835 ^@ http://purl.uniprot.org/uniprot/A8Y360 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_19807 ^@ http://purl.uniprot.org/uniprot/A8XW95 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/6238:CBG_12567 ^@ http://purl.uniprot.org/uniprot/A8XG23 ^@ Similarity ^@ Belongs to the cuticular collagen family. http://togogenome.org/gene/6238:CBG_02999 ^@ http://purl.uniprot.org/uniprot/A8WT12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.|||Nucleus http://togogenome.org/gene/6238:CBG_05942 ^@ http://purl.uniprot.org/uniprot/A8X1A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_02040 ^@ http://purl.uniprot.org/uniprot/A8WRV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/6238:CBG_13191 ^@ http://purl.uniprot.org/uniprot/A8XH94 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Nucleus http://togogenome.org/gene/6238:CBG_00462 ^@ http://purl.uniprot.org/uniprot/Q628A6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SPT4 family.|||Interacts with spt-5 to form DSIF. DSIF interacts with RNA polymerase II and with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of cdk-9 and cyclin-T (By similarity).|||May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF may enhance transcriptional pausing at sites proximal to the promoter, which may in turn facilitate the assembly of an elongation competent RNA polymerase II complex (By similarity).|||Nucleus http://togogenome.org/gene/6238:CBG_00854 ^@ http://purl.uniprot.org/uniprot/Q626S1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 22 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/6238:CBG_22058 ^@ http://purl.uniprot.org/uniprot/A8Y1F5 ^@ Similarity ^@ Belongs to the Toll-like receptor family. http://togogenome.org/gene/6238:CBG_23501 ^@ http://purl.uniprot.org/uniprot/A8Y3R9 ^@ Similarity ^@ Belongs to the PPP1R37 family. http://togogenome.org/gene/6238:CBG_06114 ^@ http://purl.uniprot.org/uniprot/A8X0V5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 25 family. http://togogenome.org/gene/6238:CBG_16815 ^@ http://purl.uniprot.org/uniprot/A8XPV3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-gamma family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/6238:CBG_23681 ^@ http://purl.uniprot.org/uniprot/A8WJ26 ^@ Caution|||Similarity ^@ Belongs to the nematode receptor-like protein srg family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_14863 ^@ http://purl.uniprot.org/uniprot/A8XKV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC3 family.|||Component of the Arp2/3 complex.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/6238:CBG_09840 ^@ http://purl.uniprot.org/uniprot/A8X9S2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/6238:CBG_09633 ^@ http://purl.uniprot.org/uniprot/A8X8L7 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/6238:CBG_00794 ^@ http://purl.uniprot.org/uniprot/A8WNU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/6238:CBG_13606 ^@ http://purl.uniprot.org/uniprot/A8XIA6 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/6238:CBG_12390 ^@ http://purl.uniprot.org/uniprot/A8XFB5 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family. http://togogenome.org/gene/6238:CBG_17341 ^@ http://purl.uniprot.org/uniprot/A8XQV0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_00075 ^@ http://purl.uniprot.org/uniprot/A8WM91 ^@ Similarity ^@ Belongs to the IL-17 family. http://togogenome.org/gene/6238:CBG_03475 ^@ http://purl.uniprot.org/uniprot/A8WV57 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_01723 ^@ http://purl.uniprot.org/uniprot/A8WR00 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_16826 ^@ http://purl.uniprot.org/uniprot/Q612A4 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Cytoplasm|||Membrane|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity). Has roles in embryogenesis and ovulation (By similarity).|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity). Interacts with V-type proton ATPase subunits a1 unc-32, a2 vha-5 and a3 vha-6 (By similarity).|||Vha-11 and vha-3 are transcribed on a dicistronic transcript where vha-3 is the upstream transcript and vha-11 the downstream. http://togogenome.org/gene/6238:CBG_08266 ^@ http://purl.uniprot.org/uniprot/A8X663 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/6238:CBG_13144 ^@ http://purl.uniprot.org/uniprot/A8XH59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/6238:CBG_23407 ^@ http://purl.uniprot.org/uniprot/A8Y3Z7 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_12291 ^@ http://purl.uniprot.org/uniprot/A8XF69 ^@ Similarity ^@ Belongs to the CND2 H2 (condensin-2 subunit 2) family. http://togogenome.org/gene/6238:CBG_09496 ^@ http://purl.uniprot.org/uniprot/A8X8Z4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DTD family.|||Cytoplasm http://togogenome.org/gene/6238:CBG_00547 ^@ http://purl.uniprot.org/uniprot/A8WNM3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/6238:CBG_18548 ^@ http://purl.uniprot.org/uniprot/Q60XS3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the G-alpha family.|||G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.|||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. In the 1-cell embryo, probably together with goa-1, controls nuclear rotation and spindle elongation during mitosis. During the first embryonic cell divisons, plays a role in gpr-1/2 cortical localization and in the proper orientation of EMS blastomere mitotic spindle. http://togogenome.org/gene/6238:CBG_00499 ^@ http://purl.uniprot.org/uniprot/A8WMT4 ^@ Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. http://togogenome.org/gene/6238:CBG_24582 ^@ http://purl.uniprot.org/uniprot/A8WL10 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/6238:CBG_15117 ^@ http://purl.uniprot.org/uniprot/A8XLF8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_03859 ^@ http://purl.uniprot.org/uniprot/A8WWX7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/6238:CBG_12060 ^@ http://purl.uniprot.org/uniprot/A8XEG5 ^@ Cofactor|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit. http://togogenome.org/gene/6238:CBG_10076 ^@ http://purl.uniprot.org/uniprot/A8XAB8 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. http://togogenome.org/gene/6238:CBG_17298 ^@ http://purl.uniprot.org/uniprot/A8XQS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/6238:CBG_21917 ^@ http://purl.uniprot.org/uniprot/Q60Q90 ^@ Function|||Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site (By similarity). http://togogenome.org/gene/6238:CBG_06058 ^@ http://purl.uniprot.org/uniprot/G2J6F9 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_17916 ^@ http://purl.uniprot.org/uniprot/A8XS37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/6238:CBG_23384 ^@ http://purl.uniprot.org/uniprot/A8Y418 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/6238:CBG_02769 ^@ http://purl.uniprot.org/uniprot/A8WTJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.|||Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG.|||Mitochondrion http://togogenome.org/gene/6238:CBG_10453 ^@ http://purl.uniprot.org/uniprot/A8XB92 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/6238:CBG_15936 ^@ http://purl.uniprot.org/uniprot/A8XNF8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_12459 ^@ http://purl.uniprot.org/uniprot/A8XFH5 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/6238:CBG_03789 ^@ http://purl.uniprot.org/uniprot/A8WWQ8 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/6238:CBG_03956 ^@ http://purl.uniprot.org/uniprot/A8WVU6 ^@ Similarity ^@ Belongs to the replication factor A protein 2 family. http://togogenome.org/gene/6238:CBG_07431 ^@ http://purl.uniprot.org/uniprot/A8X4S4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/6238:CBG_13491 ^@ http://purl.uniprot.org/uniprot/Q61B55 ^@ Function|||Similarity|||Subunit ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily.|||G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.|||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. http://togogenome.org/gene/6238:CBG_14925 ^@ http://purl.uniprot.org/uniprot/A8XL05 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/6238:CBG_23264 ^@ http://purl.uniprot.org/uniprot/A8Y4B7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome b5 family.|||Belongs to the nematode receptor-like protein sre family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/6238:CBG_19092 ^@ http://purl.uniprot.org/uniprot/A8XUR9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_04633 ^@ http://purl.uniprot.org/uniprot/A8WY41 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/6238:CBG_20095 ^@ http://purl.uniprot.org/uniprot/A8XX29 ^@ Similarity ^@ Belongs to the GOLGA6 family. http://togogenome.org/gene/6238:CBG_24755 ^@ http://purl.uniprot.org/uniprot/G2J682 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/6238:CBG_06187 ^@ http://purl.uniprot.org/uniprot/A8X0Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_14325 ^@ http://purl.uniprot.org/uniprot/A8XJR9 ^@ Similarity ^@ Belongs to the tektin family. http://togogenome.org/gene/6238:CBG_06080 ^@ http://purl.uniprot.org/uniprot/A8X0Y2 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/6238:CBG_13943 ^@ http://purl.uniprot.org/uniprot/A8XIZ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/6238:CBG_02196 ^@ http://purl.uniprot.org/uniprot/A8WSB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_23076 ^@ http://purl.uniprot.org/uniprot/A8Y4R8 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family. http://togogenome.org/gene/6238:CBG_16244 ^@ http://purl.uniprot.org/uniprot/A8XNU0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_03980 ^@ http://purl.uniprot.org/uniprot/A8WVW6 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.|||Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.|||In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.|||Nucleus http://togogenome.org/gene/6238:CBG_18040 ^@ http://purl.uniprot.org/uniprot/A8XSW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Mitochondrion http://togogenome.org/gene/6238:CBG_02944 ^@ http://purl.uniprot.org/uniprot/A8WT56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_12756 ^@ http://purl.uniprot.org/uniprot/A8XGI1 ^@ Cofactor|||Similarity ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit. http://togogenome.org/gene/6238:CBG_11014 ^@ http://purl.uniprot.org/uniprot/A8XC17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Converts acetoacetate to acetoacetyl-CoA in the cytosol.|||cytosol http://togogenome.org/gene/6238:CBG_08493 ^@ http://purl.uniprot.org/uniprot/A8X6P7 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/6238:CBG_18147 ^@ http://purl.uniprot.org/uniprot/A8XT45 ^@ Similarity ^@ Belongs to the peptidase M17 family. http://togogenome.org/gene/6238:CBG_02029 ^@ http://purl.uniprot.org/uniprot/A8WRU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_22500 ^@ http://purl.uniprot.org/uniprot/A8Y2E9 ^@ Similarity ^@ Belongs to the ATPase gamma chain family. http://togogenome.org/gene/6238:CBG_06761 ^@ http://purl.uniprot.org/uniprot/A8X308 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srg family. http://togogenome.org/gene/6238:CBG_23626 ^@ http://purl.uniprot.org/uniprot/A8WIY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FIP1 family.|||Nucleus http://togogenome.org/gene/6238:CBG_08270 ^@ http://purl.uniprot.org/uniprot/A8X667 ^@ Similarity ^@ Belongs to the helicase family. RLR subfamily. http://togogenome.org/gene/6238:CBG_05410 ^@ http://purl.uniprot.org/uniprot/Q61UA0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C78 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Interacts with odr-4.|||Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ufm-1, a ubiquitin-like modifier protein bound to a number of target proteins. Required, with oct-4, for the localization of a subset of 7 transmembrane domain odorant receptors, including odr-10, to the cilia of olfactory neurons AWA and AWC. Operates in aggregation behavior, and responses to oxygen levels.|||perinuclear region http://togogenome.org/gene/6238:CBG_15826 ^@ http://purl.uniprot.org/uniprot/A8XMY0 ^@ Similarity ^@ Belongs to the glycosyltransferase 92 family. http://togogenome.org/gene/6238:CBG_11456 ^@ http://purl.uniprot.org/uniprot/A8XCZ2 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/6238:CBG_17113 ^@ http://purl.uniprot.org/uniprot/A8XQQ3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_09574 ^@ http://purl.uniprot.org/uniprot/A8X8S3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 25 family. http://togogenome.org/gene/6238:CBG_24606 ^@ http://purl.uniprot.org/uniprot/P41957 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Bcl-2 family.|||Endomembrane system|||Interacts with asymmetric homodimer ced-4; the interaction sequesters ced-4. Interacts with egl-1; the interaction results in ced-4 release. Interacts with dre-1; the interaction inhibits ced-9 activity, either directly or indirectly. Interacts with dct-1. May form a complex composed of ced-9, ced-4 and mac-1.|||Mitochondrion membrane|||Perikaryon|||Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway.|||Synapse http://togogenome.org/gene/6238:CBG_06889 ^@ http://purl.uniprot.org/uniprot/Q61QT3 ^@ Function ^@ May have a role in mesendoderm development during embryogenesis. http://togogenome.org/gene/6238:CBG_02451 ^@ http://purl.uniprot.org/uniprot/A8WUA6 ^@ Similarity ^@ Belongs to the TTC4 family. http://togogenome.org/gene/6238:CBG_12230 ^@ http://purl.uniprot.org/uniprot/A8XEX9 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_07576 ^@ http://purl.uniprot.org/uniprot/A8X4I8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_19690 ^@ http://purl.uniprot.org/uniprot/A8XW75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_16184 ^@ http://purl.uniprot.org/uniprot/A8XNX7 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_00907 ^@ http://purl.uniprot.org/uniprot/Q626N3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM151 family.|||Membrane http://togogenome.org/gene/6238:CBG_20009 ^@ http://purl.uniprot.org/uniprot/A8XWX3 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/6238:CBG_03436 ^@ http://purl.uniprot.org/uniprot/A8WV23 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/6238:CBG_14125 ^@ http://purl.uniprot.org/uniprot/A8XJD0 ^@ Function|||Subcellular Location Annotation ^@ Cell-type specific anti-apoptotic transcription factor required for the sexually dimorphic survival of the male-specific CEM (cephalic male) sensory neurons during sex determination. In hermaphrodites, the homologous cells undergo programmed cell death due to transcriptional repression of ceh-30 by tra-1, the terminal regulator in the sex determination pathway (By similarity).|||Nucleus http://togogenome.org/gene/6238:CBG_19390 ^@ http://purl.uniprot.org/uniprot/A8XVI5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_20537 ^@ http://purl.uniprot.org/uniprot/A8XY10 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_18639 ^@ http://purl.uniprot.org/uniprot/A8XTS5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_12501 ^@ http://purl.uniprot.org/uniprot/A8XFX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/6238:CBG_23705 ^@ http://purl.uniprot.org/uniprot/A8WJ42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COA8 family.|||May be required for cytochrome c complex (COX) assembly and function, COX being the terminal component of the mitochondrial respiratory chain.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_00929 ^@ http://purl.uniprot.org/uniprot/A8WPB2 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srd family. http://togogenome.org/gene/6238:CBG_12059 ^@ http://purl.uniprot.org/uniprot/A8XEG4 ^@ Cofactor|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit. http://togogenome.org/gene/6238:CBG_23897 ^@ http://purl.uniprot.org/uniprot/A8WJJ2 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/6238:CBG_05362 ^@ http://purl.uniprot.org/uniprot/A8WZP3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/6238:CBG_06060 ^@ http://purl.uniprot.org/uniprot/G2J6I6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_14059 ^@ http://purl.uniprot.org/uniprot/A8XJ98 ^@ Developmental Stage|||Function|||Subcellular Location Annotation ^@ Expressed in 1.5-fold stage embryos, in developing pharynx and at lower levels in hypodermal cells and the hindgut (at protein level).|||Nucleus|||Putative transcription factor. Binds to specific sequence motif 5'-[TC][AGT]TGCC[GA][AT]-3' in regulatory elements of target genes such as myosin myo-2. May modulate gene expression, perhaps acting in opposition to transcription factor pha-4. Involved in morphogenesis, perhaps especially in formation of the pharynx. Plays roles in molting, feeding and morphology. http://togogenome.org/gene/6238:CBG_18599 ^@ http://purl.uniprot.org/uniprot/A8XTP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/6238:CBG_00325 ^@ http://purl.uniprot.org/uniprot/P0C660 ^@ Function|||Similarity ^@ Belongs to the PhyH family. PHYHD1 subfamily.|||Has alpha-ketoglutarate-dependent dioxygenase activity. Does not show detectable activity towards fatty acid CoA thioesters. Is not expected to be active with phytanoyl CoA (By similarity). http://togogenome.org/gene/6238:CBG_14529 ^@ http://purl.uniprot.org/uniprot/A8XK47 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/6238:CBG_04619 ^@ http://purl.uniprot.org/uniprot/A8WY28 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.|||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. http://togogenome.org/gene/6238:CBG_18063 ^@ http://purl.uniprot.org/uniprot/A8XSY2 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/6238:CBG_21322 ^@ http://purl.uniprot.org/uniprot/A8XZU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/6238:CBG_03983 ^@ http://purl.uniprot.org/uniprot/A8WVW9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF beta-subunit/FixA family.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/6238:CBG_18361 ^@ http://purl.uniprot.org/uniprot/Q60Y65 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the 4HPPD family.|||Binds 1 Fe cation per subunit.|||Key enzyme in the degradation of tyrosine. http://togogenome.org/gene/6238:CBG_09508 ^@ http://purl.uniprot.org/uniprot/A8X8Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_04746 ^@ http://purl.uniprot.org/uniprot/A8WYD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_04072 ^@ http://purl.uniprot.org/uniprot/A8WW52 ^@ Subunit ^@ Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/6238:CBG_02820 ^@ http://purl.uniprot.org/uniprot/A8WTF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FARP (FMRFamide related peptide) family.|||FMRFamides and FMRFamide-like peptides are neuropeptides. AQTFVRF-amide inhibits the activity of dissected pharyngeal myogenic muscle system (By similarity).|||Secreted http://togogenome.org/gene/6238:CBG_01744 ^@ http://purl.uniprot.org/uniprot/A8WQY3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme c group covalently per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).|||Mitochondrion intermembrane space http://togogenome.org/gene/6238:CBG_21548 ^@ http://purl.uniprot.org/uniprot/A8Y0C9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/6238:CBG_22511 ^@ http://purl.uniprot.org/uniprot/A8Y2F8 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/6238:CBG_12555 ^@ http://purl.uniprot.org/uniprot/A8XG12 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/6238:CBG_00844 ^@ http://purl.uniprot.org/uniprot/A8WPH3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_24633 ^@ http://purl.uniprot.org/uniprot/A8WL53 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/6238:CBG_13773 ^@ http://purl.uniprot.org/uniprot/A8XIN7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/6238:CBG_09597 ^@ http://purl.uniprot.org/uniprot/A8X8Q0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_04819 ^@ http://purl.uniprot.org/uniprot/A8WYJ6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_19367 ^@ http://purl.uniprot.org/uniprot/A8XVG4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.|||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. http://togogenome.org/gene/6238:CBG_11538 ^@ http://purl.uniprot.org/uniprot/Q61FQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CIA30 family.|||Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Required for normal growth and reproduction (By similarity).|||Mitochondrion http://togogenome.org/gene/6238:CBG_10070 ^@ http://purl.uniprot.org/uniprot/Q61IU3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase D subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, and The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR. http://togogenome.org/gene/6238:CBG_20497 ^@ http://purl.uniprot.org/uniprot/A8XXY0 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/6238:CBG_05782 ^@ http://purl.uniprot.org/uniprot/A8X1M9 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_01747 ^@ http://purl.uniprot.org/uniprot/A8WQY0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_14970 ^@ http://purl.uniprot.org/uniprot/A8XL45 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/6238:CBG_16360 ^@ http://purl.uniprot.org/uniprot/A8XNL8 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/6238:CBG_16606 ^@ http://purl.uniprot.org/uniprot/A8XPK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA10 subunit family.|||Mitochondrion matrix http://togogenome.org/gene/6238:CBG_03840 ^@ http://purl.uniprot.org/uniprot/A8WWW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. http://togogenome.org/gene/6238:CBG_15714 ^@ http://purl.uniprot.org/uniprot/A8XML4 ^@ Similarity ^@ Belongs to the TACO1 family. http://togogenome.org/gene/6238:CBG_05083 ^@ http://purl.uniprot.org/uniprot/A8WZ45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/6238:CBG_06056 ^@ http://purl.uniprot.org/uniprot/G2J6C3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_08385 ^@ http://purl.uniprot.org/uniprot/A8X6F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein srb family.|||Membrane http://togogenome.org/gene/6238:CBG_21182 ^@ http://purl.uniprot.org/uniprot/A8XZN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II.|||Cytoplasm|||Nucleus|||Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/6238:CBG_19955 ^@ http://purl.uniprot.org/uniprot/A8XWT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/6238:CBG_00892 ^@ http://purl.uniprot.org/uniprot/A8WPD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein srb family.|||Membrane http://togogenome.org/gene/6238:CBG_01815 ^@ http://purl.uniprot.org/uniprot/A8WQR4 ^@ Caution|||Cofactor|||Function ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Metalloprotease. http://togogenome.org/gene/6238:CBG_14907 ^@ http://purl.uniprot.org/uniprot/A8XKY8 ^@ Similarity ^@ Belongs to the PTEN phosphatase protein family. http://togogenome.org/gene/6238:CBG_23019 ^@ http://purl.uniprot.org/uniprot/A8Y3F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/6238:CBG_22802 ^@ http://purl.uniprot.org/uniprot/A8Y2X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTX family.|||Nucleus http://togogenome.org/gene/6238:CBG_01057 ^@ http://purl.uniprot.org/uniprot/A8WP00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF8 family.|||Nucleus http://togogenome.org/gene/6238:CBG_23070 ^@ http://purl.uniprot.org/uniprot/A8Y4S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ISY1 family.|||Nucleus http://togogenome.org/gene/6238:CBG_07861 ^@ http://purl.uniprot.org/uniprot/A8X5A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/6238:CBG_06076 ^@ http://purl.uniprot.org/uniprot/A8X0Y5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/6238:CBG_05570 ^@ http://purl.uniprot.org/uniprot/A8X062 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 7B2 family.|||Secreted http://togogenome.org/gene/6238:CBG_07054 ^@ http://purl.uniprot.org/uniprot/A8X3T4 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/6238:CBG_21178 ^@ http://purl.uniprot.org/uniprot/A8XZP2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Cytoplasm|||Homodimer.|||Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. http://togogenome.org/gene/6238:CBG_22015 ^@ http://purl.uniprot.org/uniprot/A8Y1C2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_01199 ^@ http://purl.uniprot.org/uniprot/A8WPT8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_15713 ^@ http://purl.uniprot.org/uniprot/A8XML3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RAD3/XPD subfamily.|||Nucleus http://togogenome.org/gene/6238:CBG_03402 ^@ http://purl.uniprot.org/uniprot/A8WUZ1 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. http://togogenome.org/gene/6238:CBG_02380 ^@ http://purl.uniprot.org/uniprot/A8WUG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.|||Membrane http://togogenome.org/gene/6238:CBG_09259 ^@ http://purl.uniprot.org/uniprot/A8X9I3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_01104 ^@ http://purl.uniprot.org/uniprot/A8WPK3 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6238:CBG_03813 ^@ http://purl.uniprot.org/uniprot/A8WWT2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_13148 ^@ http://purl.uniprot.org/uniprot/A8XH63 ^@ Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family. http://togogenome.org/gene/6238:CBG_07150 ^@ http://purl.uniprot.org/uniprot/A8X3L3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_22847 ^@ http://purl.uniprot.org/uniprot/A8Y371 ^@ Similarity ^@ Belongs to the FAX family. http://togogenome.org/gene/6238:CBG_20626 ^@ http://purl.uniprot.org/uniprot/A8XY86 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/6238:CBG_01253 ^@ http://purl.uniprot.org/uniprot/A8WPY7 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/6238:CBG_13471 ^@ http://purl.uniprot.org/uniprot/A8XHN9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_03915 ^@ http://purl.uniprot.org/uniprot/A8WVR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/6238:CBG_20006 ^@ http://purl.uniprot.org/uniprot/A8XWX1 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/6238:CBG_12356 ^@ http://purl.uniprot.org/uniprot/A8XF85 ^@ Similarity ^@ Belongs to the dihydrofolate reductase family. http://togogenome.org/gene/6238:CBG_23248 ^@ http://purl.uniprot.org/uniprot/A8Y4D2 ^@ Similarity ^@ Belongs to the vinculin/alpha-catenin family. http://togogenome.org/gene/6238:CBG_23930 ^@ http://purl.uniprot.org/uniprot/A8WJL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS4 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_12067 ^@ http://purl.uniprot.org/uniprot/A8XEH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/6238:CBG_04179 ^@ http://purl.uniprot.org/uniprot/A8WWC8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/6238:CBG_23127 ^@ http://purl.uniprot.org/uniprot/Q60MJ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the G-alpha family. G(q) subfamily.|||G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.|||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. http://togogenome.org/gene/6238:CBG_02802 ^@ http://purl.uniprot.org/uniprot/A8WTH2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6238:CBG_00335 ^@ http://purl.uniprot.org/uniprot/A8WMU9 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/6238:CBG_05717 ^@ http://purl.uniprot.org/uniprot/A8X1T5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/6238:CBG_04617 ^@ http://purl.uniprot.org/uniprot/A8WY26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRS1 family.|||Involved in ribosomal large subunit assembly.|||nucleolus http://togogenome.org/gene/6238:CBG_05898 ^@ http://purl.uniprot.org/uniprot/A8X1D8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_16441 ^@ http://purl.uniprot.org/uniprot/A8XP32 ^@ Similarity ^@ Belongs to the poly(ADP-ribose) glycohydrolase family. http://togogenome.org/gene/6238:CBG_02743 ^@ http://purl.uniprot.org/uniprot/A8WTL7 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/6238:CBG_01551 ^@ http://purl.uniprot.org/uniprot/A8WRE1 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rieske iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Membrane|||Mitochondrion inner membrane|||The Rieske protein is a high potential 2Fe-2S protein. http://togogenome.org/gene/6238:CBG_22739 ^@ http://purl.uniprot.org/uniprot/A8Y325 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Structural component of the gap junctions.|||gap junction http://togogenome.org/gene/6238:CBG_23145 ^@ http://purl.uniprot.org/uniprot/A8Y4L5 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/6238:CBG_19191 ^@ http://purl.uniprot.org/uniprot/A8XV16 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6238:CBG_18897 ^@ http://purl.uniprot.org/uniprot/A8XUB2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. http://togogenome.org/gene/6238:CBG_19741 ^@ http://purl.uniprot.org/uniprot/A8XWF3 ^@ Subcellular Location Annotation|||Subunit ^@ Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. http://togogenome.org/gene/6238:CBG_02962 ^@ http://purl.uniprot.org/uniprot/A8WT39 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/6238:CBG_03307 ^@ http://purl.uniprot.org/uniprot/A8WSC0 ^@ Similarity ^@ Belongs to the TRIAP1/MDM35 family. http://togogenome.org/gene/6238:CBG_22523 ^@ http://purl.uniprot.org/uniprot/A8Y2G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Secreted http://togogenome.org/gene/6238:CBG_22453 ^@ http://purl.uniprot.org/uniprot/A8Y2B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/6238:CBG_02945 ^@ http://purl.uniprot.org/uniprot/A8WT55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX15/CtaA family.|||Membrane http://togogenome.org/gene/6238:CBG_23504 ^@ http://purl.uniprot.org/uniprot/A8Y3R8 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/6238:CBG_00650 ^@ http://purl.uniprot.org/uniprot/A8WND3 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_00496 ^@ http://purl.uniprot.org/uniprot/A8WMT1 ^@ Function|||Similarity ^@ Belongs to the SKP1 family.|||Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. http://togogenome.org/gene/6238:CBG_12479 ^@ http://purl.uniprot.org/uniprot/A8XFV0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL19 family. http://togogenome.org/gene/6238:CBG_06111 ^@ http://purl.uniprot.org/uniprot/A8X0V7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 25 family. http://togogenome.org/gene/6238:CBG_09178 ^@ http://purl.uniprot.org/uniprot/A8X888 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_14166 ^@ http://purl.uniprot.org/uniprot/A8XJF7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/6238:CBG_01060 ^@ http://purl.uniprot.org/uniprot/A8WNZ7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_18195 ^@ http://purl.uniprot.org/uniprot/A8XT87 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/6238:CBG_15299 ^@ http://purl.uniprot.org/uniprot/A8XLW1 ^@ Cofactor|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/6238:CBG_01690 ^@ http://purl.uniprot.org/uniprot/A8WR28 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/6238:CBG_01364 ^@ http://purl.uniprot.org/uniprot/A8WQ88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/6238:CBG_09727 ^@ http://purl.uniprot.org/uniprot/A8X8E6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/6238:CBG_09795 ^@ http://purl.uniprot.org/uniprot/A8X9N2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/6238:CBG_17987 ^@ http://purl.uniprot.org/uniprot/A8XSR5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_06905 ^@ http://purl.uniprot.org/uniprot/A8X3B9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_06300 ^@ http://purl.uniprot.org/uniprot/A8X1W7 ^@ Similarity ^@ Belongs to the glycosyltransferase 92 family. http://togogenome.org/gene/6238:CBG_08279 ^@ http://purl.uniprot.org/uniprot/E3CU02 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. http://togogenome.org/gene/6238:CBG_15265 ^@ http://purl.uniprot.org/uniprot/A8XLI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/6238:CBG_16797 ^@ http://purl.uniprot.org/uniprot/A8XPU0 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/6238:CBG_13074 ^@ http://purl.uniprot.org/uniprot/A8XH09 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6238:CBG_09545 ^@ http://purl.uniprot.org/uniprot/P0C659 ^@ Similarity ^@ Belongs to the EIF1AD family. http://togogenome.org/gene/6238:CBG_23441 ^@ http://purl.uniprot.org/uniprot/G2J6I6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_07973 ^@ http://purl.uniprot.org/uniprot/A8X5H6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NnrE/AIBP family.|||Binds 1 potassium ion per subunit.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. http://togogenome.org/gene/6238:CBG_21774 ^@ http://purl.uniprot.org/uniprot/Q8I8U6 ^@ Function|||Subunit ^@ Component of a complex containing fem-1, fem-2 and fem-3 (By similarity). Interacts with fem-1 and fem-2 (via N-terminus) (By similarity). Part of a E3 ubiquitin-protein ligase complex, at least composed of cul-2, elc-1, tra-1, fem-1, fem-2 and fem-3; mediates the ubiquitination and subsequent proteasomal degradation of tra-1 (By similarity). Interacts with sel-10 (By similarity). Interacts with tra-2 (PubMed:12477393).|||Required for male development. In XO (male) animals, fem-3 directs male differentiation in all tissues. In XX (hermaphrodite animals), it specifies the first 80 or so germ cells to be sperm. Negatively regulates male development when bound to tra-2. http://togogenome.org/gene/6238:CBG_16730 ^@ http://purl.uniprot.org/uniprot/A8XPQ0 ^@ Similarity ^@ Belongs to the VPS52 family. http://togogenome.org/gene/6238:CBG_10007 ^@ http://purl.uniprot.org/uniprot/A8XA58 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cks-1 (By similarity).|||Nucleus|||Phosphorylation both activates and inactivates the enzyme depending on the site of phosphorylation.|||Plays a key role in the control of the eukaryotic cell cycle (By similarity). Required for entry into S-phase and mitosis (By similarity). Acts as a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). May function in concert with npp-16 to arrest prophase blastomeres in response to anoxia (By similarity).|||centrosome http://togogenome.org/gene/6238:CBG_16434 ^@ http://purl.uniprot.org/uniprot/A8XP27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS33 family.|||Mitochondrion http://togogenome.org/gene/6238:CBG_17759 ^@ http://purl.uniprot.org/uniprot/A8XRQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RED family.|||Nucleus http://togogenome.org/gene/6238:CBG_03667 ^@ http://purl.uniprot.org/uniprot/A8WVJ8 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/6238:CBG_13540 ^@ http://purl.uniprot.org/uniprot/A8XI50 ^@ Similarity ^@ Belongs to the PTEN phosphatase protein family. http://togogenome.org/gene/6238:CBG_11203 ^@ http://purl.uniprot.org/uniprot/A8XCP8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_10467 ^@ http://purl.uniprot.org/uniprot/A8XBA3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_20492 ^@ http://purl.uniprot.org/uniprot/A8XXX5 ^@ Cofactor ^@ Binds one Zn(2+) ion per subunit. http://togogenome.org/gene/6238:CBG_01526 ^@ http://purl.uniprot.org/uniprot/A8WQH2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxidase family. XPO subfamily.|||Binds 1 Ca(2+) ion per subunit.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per subunit.|||Catalyzes the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV NC1 hexamer (By similarity). Plays a role in the attachment of tissues and in axonal guidance during early developmental stages (By similarity). May functionally antagonize the peroxidasin pxn-2 to maintain neuronal development (By similarity).|||extracellular matrix http://togogenome.org/gene/6238:CBG_13316 ^@ http://purl.uniprot.org/uniprot/G2J6T4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-delta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/6238:CBG_03028 ^@ http://purl.uniprot.org/uniprot/A8WSY7 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_03758 ^@ http://purl.uniprot.org/uniprot/A8WWN0 ^@ Function|||Similarity ^@ Belongs to the SKP1 family.|||Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. http://togogenome.org/gene/6238:CBG_12397 ^@ http://purl.uniprot.org/uniprot/A8XFC1 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_00622 ^@ http://purl.uniprot.org/uniprot/A8WNF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMCO1 family.|||Calcium-selective channel required to prevent calcium stores from overfilling.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_05282 ^@ http://purl.uniprot.org/uniprot/A8WZJ1 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srd family. http://togogenome.org/gene/6238:CBG_01803 ^@ http://purl.uniprot.org/uniprot/A8WQS6 ^@ Similarity ^@ Belongs to the HPF1 family. http://togogenome.org/gene/6238:CBG_08963 ^@ http://purl.uniprot.org/uniprot/A8X847 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. http://togogenome.org/gene/6238:CBG_14297 ^@ http://purl.uniprot.org/uniprot/A8XJQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/6238:CBG_16528 ^@ http://purl.uniprot.org/uniprot/A8XPF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM144 family.|||Membrane http://togogenome.org/gene/6238:CBG_02987 ^@ http://purl.uniprot.org/uniprot/A8WT18 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_09874 ^@ http://purl.uniprot.org/uniprot/A8X9V4 ^@ Function|||Similarity ^@ Belongs to the tubulin--tyrosine ligase family.|||Monoglutamylase which modifies tubulin, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins. Involved in the side-chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin. Involved in side-chain glutamylation of tubulin in sensory cilia. Together with ttll-5 and ttll-11, required for male mating. http://togogenome.org/gene/6238:CBG_20294 ^@ http://purl.uniprot.org/uniprot/A8XXF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_06541 ^@ http://purl.uniprot.org/uniprot/A8X2H3 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6238:CBG_19177 ^@ http://purl.uniprot.org/uniprot/A8XV05 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/6238:CBG_02732 ^@ http://purl.uniprot.org/uniprot/A8WTM4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/6238:CBG_01313 ^@ http://purl.uniprot.org/uniprot/A8WQ42 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/6238:CBG_14833 ^@ http://purl.uniprot.org/uniprot/A8XKT0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/6238:CBG_20928 ^@ http://purl.uniprot.org/uniprot/A8XYZ2 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SDHAF2 family.|||Interacts with the flavoprotein subunit within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.|||This protein may be expected to contain an N-terminal transit peptide but none has been predicted. http://togogenome.org/gene/6238:CBG_09462 ^@ http://purl.uniprot.org/uniprot/A8X919 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCU (TC 1.A.77) family.|||Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).|||Membrane|||Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_13774 ^@ http://purl.uniprot.org/uniprot/A8XIN8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6238:CBG_06118 ^@ http://purl.uniprot.org/uniprot/A8X0V2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/6238:CBG_17484 ^@ http://purl.uniprot.org/uniprot/A8XR33 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srg family. http://togogenome.org/gene/6238:CBG_16808 ^@ http://purl.uniprot.org/uniprot/A8XPU7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CPSF1 family.|||CPSF is a heterotetramer composed of four distinct subunits 160 (cpsf-1), 100 (cpsf-2), 70 (cpsf-3), and 30 kDa (cpsf-4).|||CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity).|||Nucleus http://togogenome.org/gene/6238:CBG_04825 ^@ http://purl.uniprot.org/uniprot/A8WYK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/6238:CBG_09730 ^@ http://purl.uniprot.org/uniprot/G2J6N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecE/SEC61-gamma family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_07948 ^@ http://purl.uniprot.org/uniprot/A8X5F7 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/6238:CBG_22089 ^@ http://purl.uniprot.org/uniprot/A8Y1I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin interacting component (NIC) family.|||nuclear pore complex http://togogenome.org/gene/6238:CBG_21168 ^@ http://purl.uniprot.org/uniprot/A8XZC3 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/6238:CBG_23231 ^@ http://purl.uniprot.org/uniprot/A8Y4E5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/6238:CBG_22942 ^@ http://purl.uniprot.org/uniprot/A8Y3L8 ^@ Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family. http://togogenome.org/gene/6238:CBG_00029 ^@ http://purl.uniprot.org/uniprot/Q9GZ03 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_18371 ^@ http://purl.uniprot.org/uniprot/A8XSJ6 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/6238:CBG_19218 ^@ http://purl.uniprot.org/uniprot/A8XV38 ^@ Similarity ^@ Belongs to the xanthine dehydrogenase family. http://togogenome.org/gene/6238:CBG_02394 ^@ http://purl.uniprot.org/uniprot/Q621Q3 ^@ Function ^@ Required maternally for early embryonic cell divisions. May have a role in DNA replication. http://togogenome.org/gene/6238:CBG_09959 ^@ http://purl.uniprot.org/uniprot/A8XA18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/6238:CBG_06530 ^@ http://purl.uniprot.org/uniprot/A8X2G2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_23739 ^@ http://purl.uniprot.org/uniprot/A8WJ65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF-beta family.|||Nucleus http://togogenome.org/gene/6238:CBG_13338 ^@ http://purl.uniprot.org/uniprot/A8XHL9 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/6238:CBG_18691 ^@ http://purl.uniprot.org/uniprot/A8XTW5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/6238:CBG_03118 ^@ http://purl.uniprot.org/uniprot/A8WSR2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_01272 ^@ http://purl.uniprot.org/uniprot/A8WQ04 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_21613 ^@ http://purl.uniprot.org/uniprot/A8Y075 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_21753 ^@ http://purl.uniprot.org/uniprot/Q60QM8 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/6238:CBG_17088 ^@ http://purl.uniprot.org/uniprot/A8XQE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_20470 ^@ http://purl.uniprot.org/uniprot/A8XXV5 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_07067 ^@ http://purl.uniprot.org/uniprot/A8X3S4 ^@ Similarity ^@ Belongs to the NFYB/HAP3 subunit family. http://togogenome.org/gene/6238:CBG_10288 ^@ http://purl.uniprot.org/uniprot/A8XAP1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_09153 ^@ http://purl.uniprot.org/uniprot/A8X872 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/6238:CBG_16596 ^@ http://purl.uniprot.org/uniprot/A8XPJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat UTP18 family.|||nucleolus http://togogenome.org/gene/6238:CBG_10846 ^@ http://purl.uniprot.org/uniprot/A8XC45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_05113 ^@ http://purl.uniprot.org/uniprot/A8WZ83 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS3/PSF3 family.|||Component of the GINS complex.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication. http://togogenome.org/gene/6238:CBG_20719 ^@ http://purl.uniprot.org/uniprot/E3CU80 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_21316 ^@ http://purl.uniprot.org/uniprot/A8XZT8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/6238:CBG_05844 ^@ http://purl.uniprot.org/uniprot/G2J745 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_03302 ^@ http://purl.uniprot.org/uniprot/A8WSC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DDOST 48 kDa subunit family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). http://togogenome.org/gene/6238:CBG_13381 ^@ http://purl.uniprot.org/uniprot/A8XHW5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polycystin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/6238:CBG_11736 ^@ http://purl.uniprot.org/uniprot/A8XDU8 ^@ Caution|||Similarity ^@ Belongs to the globin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_13345 ^@ http://purl.uniprot.org/uniprot/A8XHZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_02540 ^@ http://purl.uniprot.org/uniprot/A8WU31 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Autophosphorylates in vitro.|||Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.|||Nucleus|||Serine/threonine kinase that phosphorylates baf-1, thus regulating the association of baf-1 with chromatin and nuclear membrane proteins during nuclear envelope formation. May act through the egl-17 signaling pathway. Essential in hermaphrodites for formation of the vulva, uterus, and uterine seam cells and for development and maintenance of the somatic gonad and thus the germ line. Acts to prevent cep-1 from triggering an inappropriate cell cycle arrest, thereby promoting germ cell proliferation. Regulates anchor cell polarity and the timing of anchor cell invasion through the basement membranes separating vulval and somatic gonadal cells during the L3 larval stage (By similarity). http://togogenome.org/gene/6238:CBG_23048 ^@ http://purl.uniprot.org/uniprot/A8Y3D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Golgi pH regulator (TC 1.A.38) family.|||Membrane http://togogenome.org/gene/6238:CBG_18188 ^@ http://purl.uniprot.org/uniprot/A8XT80 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/6238:CBG_05149 ^@ http://purl.uniprot.org/uniprot/A8WZ58 ^@ Similarity ^@ Belongs to the cytidylyltransferase family. http://togogenome.org/gene/6238:CBG_19031 ^@ http://purl.uniprot.org/uniprot/A8XUL9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/6238:CBG_20923 ^@ http://purl.uniprot.org/uniprot/A8XYY8 ^@ Similarity ^@ Belongs to the SIN1 family. http://togogenome.org/gene/6238:CBG_13738 ^@ http://purl.uniprot.org/uniprot/A8XIK7 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6238:CBG_11004 ^@ http://purl.uniprot.org/uniprot/A8XC08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).|||Nucleus http://togogenome.org/gene/6238:CBG_23480 ^@ http://purl.uniprot.org/uniprot/A8Y3T7 ^@ Similarity ^@ Belongs to the FAX family. http://togogenome.org/gene/6238:CBG_14923 ^@ http://purl.uniprot.org/uniprot/A8XL03 ^@ Similarity ^@ Belongs to the WD repeat PWP2 family. http://togogenome.org/gene/6238:CBG_10777 ^@ http://purl.uniprot.org/uniprot/A8XBS2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_02656 ^@ http://purl.uniprot.org/uniprot/A8WTT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/6238:CBG_06010 ^@ http://purl.uniprot.org/uniprot/A8X142 ^@ Similarity ^@ Belongs to the peptidase C13 family. http://togogenome.org/gene/6238:CBG_21258 ^@ http://purl.uniprot.org/uniprot/A8XZP8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/6238:CBG_04751 ^@ http://purl.uniprot.org/uniprot/A8WYE0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RNase HII family. Eukaryotic subfamily.|||Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/6238:CBG_14447 ^@ http://purl.uniprot.org/uniprot/A8XJZ4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/6238:CBG_09087 ^@ http://purl.uniprot.org/uniprot/A8X7U1 ^@ Similarity ^@ Belongs to the NUF2 family. http://togogenome.org/gene/6238:CBG_13602 ^@ http://purl.uniprot.org/uniprot/A8XIA2 ^@ Similarity ^@ Belongs to the VPS25 family. http://togogenome.org/gene/6238:CBG_20617 ^@ http://purl.uniprot.org/uniprot/G2J6N5 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_06436 ^@ http://purl.uniprot.org/uniprot/A8X280 ^@ Similarity ^@ Belongs to the CFAP36 family. http://togogenome.org/gene/6238:CBG_20985 ^@ http://purl.uniprot.org/uniprot/A8XZ38 ^@ Caution|||Similarity ^@ Belongs to the nematode receptor-like protein srg family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_12425 ^@ http://purl.uniprot.org/uniprot/A8XFE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/6238:CBG_00979 ^@ http://purl.uniprot.org/uniprot/Q626H5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the plexin family.|||Cell membrane|||Interacts with mab-20.|||Involved as a receptor for mab-20/sema-2a in the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, involved in precursor cell sorting and in the formation of distinct sensory rays. Involved in axon guidance of SDQL neurons during neurogenesis. http://togogenome.org/gene/6238:CBG_12118 ^@ http://purl.uniprot.org/uniprot/A8XES8 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srg family. http://togogenome.org/gene/6238:CBG_19173 ^@ http://purl.uniprot.org/uniprot/A8XV01 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/6238:CBG_09460 ^@ http://purl.uniprot.org/uniprot/A8X921 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||Structural component of the gap junctions.|||gap junction http://togogenome.org/gene/6238:CBG_23416 ^@ http://purl.uniprot.org/uniprot/Q60LV4 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A band|||Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells.|||MHC A and MHC B are found exclusively in the body wall muscle. They co-assemble into body wall thick filament.|||Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).|||The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.|||myofibril http://togogenome.org/gene/6238:CBG_12949 ^@ http://purl.uniprot.org/uniprot/G2J6S2 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/6238:CBG_07938 ^@ http://purl.uniprot.org/uniprot/A8X5E7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. http://togogenome.org/gene/6238:CBG_08658 ^@ http://purl.uniprot.org/uniprot/A8X6V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 1 family.|||Nucleus http://togogenome.org/gene/6238:CBG_07733 ^@ http://purl.uniprot.org/uniprot/A8X473 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Early endosome membrane|||Endosome|||phagosome|||trans-Golgi network membrane http://togogenome.org/gene/6238:CBG_11998 ^@ http://purl.uniprot.org/uniprot/A8XEB2 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/6238:CBG_13217 ^@ http://purl.uniprot.org/uniprot/A8XHB4 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/6238:CBG_21683 ^@ http://purl.uniprot.org/uniprot/A8Y0R3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/6238:CBG_10154 ^@ http://purl.uniprot.org/uniprot/A8XAI1 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/6238:CBG_09606 ^@ http://purl.uniprot.org/uniprot/A8X8P2 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/6238:CBG_20174 ^@ http://purl.uniprot.org/uniprot/A8XX92 ^@ Function|||Similarity ^@ Belongs to the glyoxalase I family.|||Thought to act as a glyoxalase. May remove methylglyoxal from mitochondrial proteins. Has roles in reducing oxidative stress and increasing lifespan (By similarity). http://togogenome.org/gene/6238:CBG_17531 ^@ http://purl.uniprot.org/uniprot/A8XR65 ^@ Similarity ^@ Belongs to the cuticular collagen family. http://togogenome.org/gene/6238:CBG_18146 ^@ http://purl.uniprot.org/uniprot/A8XT44 ^@ Similarity ^@ Belongs to the CutC family. http://togogenome.org/gene/6238:CBG_19186 ^@ http://purl.uniprot.org/uniprot/A8XV11 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/6238:CBG_23351 ^@ http://purl.uniprot.org/uniprot/A8Y446 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6238:CBG_13328 ^@ http://purl.uniprot.org/uniprot/A8XHL3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.|||Mitochondrion|||Nucleus http://togogenome.org/gene/6238:CBG_19029 ^@ http://purl.uniprot.org/uniprot/A8XUL7 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_21612 ^@ http://purl.uniprot.org/uniprot/A8Y074 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Chromosome|||Nucleus http://togogenome.org/gene/6238:CBG_06011 ^@ http://purl.uniprot.org/uniprot/A8X141 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/6238:CBG_06072 ^@ http://purl.uniprot.org/uniprot/A8X0Z0 ^@ Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.|||Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes. http://togogenome.org/gene/6238:CBG_09058 ^@ http://purl.uniprot.org/uniprot/A8X7W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/6238:CBG_24603 ^@ http://purl.uniprot.org/uniprot/A8WL39 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/6238:CBG_05218 ^@ http://purl.uniprot.org/uniprot/A8WZE9 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.|||The WWE domain mediates non-covalent poly(ADP-ribose)-binding.|||Ubiquitinated; autoubiquitinated.|||cytosol http://togogenome.org/gene/6238:CBG_22709 ^@ http://purl.uniprot.org/uniprot/A8Y300 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/6238:CBG_01036 ^@ http://purl.uniprot.org/uniprot/A8WP19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/6238:CBG_02389 ^@ http://purl.uniprot.org/uniprot/A8WUF6 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_01067 ^@ http://purl.uniprot.org/uniprot/Q5CAS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/6238:CBG_17087 ^@ http://purl.uniprot.org/uniprot/A8XQE9 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/6238:CBG_12415 ^@ http://purl.uniprot.org/uniprot/A8XFD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Membrane http://togogenome.org/gene/6238:CBG_03154 ^@ http://purl.uniprot.org/uniprot/A8WSN5 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_11770 ^@ http://purl.uniprot.org/uniprot/A8XE06 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_19391 ^@ http://purl.uniprot.org/uniprot/A8XVI6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_06466 ^@ http://purl.uniprot.org/uniprot/A8X2A3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_18931 ^@ http://purl.uniprot.org/uniprot/A8XUD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ATPase subunit F6 family.|||Membrane|||Mitochondrion http://togogenome.org/gene/6238:CBG_12550 ^@ http://purl.uniprot.org/uniprot/A8XG07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tim44 family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_20733 ^@ http://purl.uniprot.org/uniprot/A8XYH2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_23177 ^@ http://purl.uniprot.org/uniprot/A8Y4I6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6238:CBG_22047 ^@ http://purl.uniprot.org/uniprot/A8Y1E9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft (By similarity).|||Nucleus http://togogenome.org/gene/6238:CBG_11181 ^@ http://purl.uniprot.org/uniprot/A8XCM7 ^@ Similarity ^@ Belongs to the proteasome subunit p27 family. http://togogenome.org/gene/6238:CBG_23418 ^@ http://purl.uniprot.org/uniprot/A8Y3Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_14070 ^@ http://purl.uniprot.org/uniprot/A8XJA4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_07113 ^@ http://purl.uniprot.org/uniprot/A8X3N6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/6238:CBG_21580 ^@ http://purl.uniprot.org/uniprot/A8Y0F3 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/6238:CBG_20784 ^@ http://purl.uniprot.org/uniprot/A8XYL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/6238:CBG_23102 ^@ http://purl.uniprot.org/uniprot/A8Y4P8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase F subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/6238:CBG_02309 ^@ http://purl.uniprot.org/uniprot/A8WUM4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/6238:CBG_23090 ^@ http://purl.uniprot.org/uniprot/A8Y4R0 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/6238:CBG_15204 ^@ http://purl.uniprot.org/uniprot/A8XLP2 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/6238:CBG_05355 ^@ http://purl.uniprot.org/uniprot/P35074 ^@ Domain|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Chromosome|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. Interacts with sig-7.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Involved in the transcription of several genes including those involved in embryogenesis.|||Following transcription stress, the elongating form of RNA polymerase II (RNA pol IIo) is polyubiquitinated via 'Lys-63'-linkages on Lys-1260 at DNA damage sites without leading to degradation: ubiquitination promotes RNA pol IIo backtracking to allow access by the transcription-coupled nucleotide excision repair (TC-NER) machinery. Subsequent DEF1-dependent polyubiquitination by the elongin complex via 'Lys-48'-linkages may lead to proteasome-mediated degradation; presumably at stalled RNA pol II where TC-NER has failed, to halt global transcription and enable 'last resort' DNA repair pathways.|||Nucleus|||The C-terminal domain (CTD) serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing.|||The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion temporarily coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits. The ribonucleoside triphosphate is transferred by a rotation to the nucleotide addition (A) site for pairing with the template DNA. The catalytic A site involves three conserved aspartate residues of the RNA Pol II largest subunit which permanently coordinate a second magnesium ion.|||The tandem 7 residues repeats in the C-terminal domain (CTD) can be highly phosphorylated. The phosphorylation activates Pol II. Phosphorylation occurs mainly at residues 'Ser-2' and 'Ser-5' of the heptapeptide repeat and starts at the 3- to 4-cell embryonic stage. This phosphorylation also occurs in the early stages of oocyte development and is not detected in oocytes arrested at the meiotic diakinesis stage. In the somatic lineage, phosphorylation at 'Ser-2' is mediated by cdk-12 downstream of cdk-9 whereas in the germline lineage cdk-12 phosphorylates 'Ser-2' independently of cdk-9. Phosphorylation is likely mediated by cdk-7. May be dephosphorylated by fcp-1 in diakinetic oocytes and in 1-cell and 2-cell embryos. Dephosphorylated at 'Ser-5' of the heptapeptide repeat by ssup-72. The phosphorylation state is believed to result from the balanced action of site-specific CTD kinases and phosphatase, and a 'CTD code' that specifies the position of Pol II within the transcription cycle has been proposed. http://togogenome.org/gene/6238:CBG_03799 ^@ http://purl.uniprot.org/uniprot/A8WWR8 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/6238:CBG_11909 ^@ http://purl.uniprot.org/uniprot/A8XEK6 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/6238:CBG_09750 ^@ http://purl.uniprot.org/uniprot/A8XAJ2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_03264 ^@ http://purl.uniprot.org/uniprot/A8WSF3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||cytoskeleton http://togogenome.org/gene/6238:CBG_09944 ^@ http://purl.uniprot.org/uniprot/A8XA05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_04291 ^@ http://purl.uniprot.org/uniprot/Q61WR2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.|||Required during maturation of the 40S ribosomal subunit in the nucleolus.|||nucleolus http://togogenome.org/gene/6238:CBG_06988 ^@ http://purl.uniprot.org/uniprot/A8X3Z3 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/6238:CBG_06902 ^@ http://purl.uniprot.org/uniprot/A8X3B6 ^@ Similarity ^@ Belongs to the ODR-4 family. http://togogenome.org/gene/6238:CBG_20050 ^@ http://purl.uniprot.org/uniprot/A8XX02 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_12968 ^@ http://purl.uniprot.org/uniprot/A8XGS6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Cytoplasm|||Homotrimer.|||Nucleus http://togogenome.org/gene/6238:CBG_03371 ^@ http://purl.uniprot.org/uniprot/A8WUW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Membrane http://togogenome.org/gene/6238:CBG_12097 ^@ http://purl.uniprot.org/uniprot/A8XEJ8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||The PAL motif is required for normal active site conformation. http://togogenome.org/gene/6238:CBG_09459 ^@ http://purl.uniprot.org/uniprot/A8X922 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/6238:CBG_18291 ^@ http://purl.uniprot.org/uniprot/Q17297 ^@ Domain|||Function|||Similarity ^@ Adopts an immunoglobulin-like beta-sandwich fold forming a hydrophobic cavity that capture N-terminally myristoylated target peptides. Phe residues within the hydrophobic beta sandwich are required for myristate binding (By similarity).|||Belongs to the PDE6D/unc-119 family.|||Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system (By similarity). http://togogenome.org/gene/6238:CBG_07447 ^@ http://purl.uniprot.org/uniprot/A8X4R1 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_01213 ^@ http://purl.uniprot.org/uniprot/A8WPU9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_22748 ^@ http://purl.uniprot.org/uniprot/A8Y331 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6238:CBG_10495 ^@ http://purl.uniprot.org/uniprot/A8XAX8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_00049 ^@ http://purl.uniprot.org/uniprot/Q4VT26 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units, alpha, beta and gamma. Interacts with gpb-1 and gpb-2.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/6238:CBG_18013 ^@ http://purl.uniprot.org/uniprot/A8XST9 ^@ Cofactor|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/6238:CBG_18203 ^@ http://purl.uniprot.org/uniprot/A8XS54 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SNF8 family.|||Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II). http://togogenome.org/gene/6238:CBG_19298 ^@ http://purl.uniprot.org/uniprot/A8XVA6 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/6238:CBG_10905 ^@ http://purl.uniprot.org/uniprot/A8XC86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_22943 ^@ http://purl.uniprot.org/uniprot/A8Y3L7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.|||Mitochondrion http://togogenome.org/gene/6238:CBG_10328 ^@ http://purl.uniprot.org/uniprot/A8XAK9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/6238:CBG_23318 ^@ http://purl.uniprot.org/uniprot/A8Y475 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_16956 ^@ http://purl.uniprot.org/uniprot/A8XQ51 ^@ Similarity ^@ Belongs to the glycosyltransferase 92 family. http://togogenome.org/gene/6238:CBG_07571 ^@ http://purl.uniprot.org/uniprot/A8X4J2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/6238:CBG_12014 ^@ http://purl.uniprot.org/uniprot/A8XEC6 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/6238:CBG_23445 ^@ http://purl.uniprot.org/uniprot/G2J745 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_13528 ^@ http://purl.uniprot.org/uniprot/A8XI38 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/6238:CBG_13975 ^@ http://purl.uniprot.org/uniprot/A8XIW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/6238:CBG_19263 ^@ http://purl.uniprot.org/uniprot/Q60W52 ^@ Function|||Similarity|||Subunit ^@ Belongs to the G-alpha family. G(q) subfamily.|||G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.|||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Promotes transcription of 3',5'-cyclic phosphodiesterases pde-1 and pde-5, leading to reduced cGMP levels in sensory neurons. This causes suppression of insulin production and signaling which leads to increased daf-16 activity and contributes to increased adult lifespan and resistance to oxidative stress. In addition, by reducing cGMP levels, inhibits TGF-beta signaling pathways. Involved in behavioral response to P.aeruginosa by controlling the expression of daf-7, a member of the TGF-beta family, in ASJ sensory neurons. http://togogenome.org/gene/6238:CBG_06913 ^@ http://purl.uniprot.org/uniprot/A8X3C6 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/6238:CBG_00560 ^@ http://purl.uniprot.org/uniprot/A8WNL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_01646 ^@ http://purl.uniprot.org/uniprot/A8WR63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. http://togogenome.org/gene/6238:CBG_17200 ^@ http://purl.uniprot.org/uniprot/A8XQK6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6238:CBG_17477 ^@ http://purl.uniprot.org/uniprot/A8XR39 ^@ Caution|||Similarity ^@ Belongs to the nematode receptor-like protein srg family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_03049 ^@ http://purl.uniprot.org/uniprot/A8WSX0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_19960 ^@ http://purl.uniprot.org/uniprot/A8XWT7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_18072 ^@ http://purl.uniprot.org/uniprot/A8XSZ0 ^@ Similarity ^@ Belongs to the GPATCH1 family. http://togogenome.org/gene/6238:CBG_03338 ^@ http://purl.uniprot.org/uniprot/Q61YZ4 ^@ Similarity ^@ Belongs to the LovG family. http://togogenome.org/gene/6238:CBG_22152 ^@ http://purl.uniprot.org/uniprot/A8Y1N5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG5 family.|||Conjugated with atg-12.|||Involved in autophagic vesicle formation.|||Preautophagosomal structure membrane http://togogenome.org/gene/6238:CBG_04048 ^@ http://purl.uniprot.org/uniprot/A8WW31 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/6238:CBG_02290 ^@ http://purl.uniprot.org/uniprot/A8WUN9 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/6238:CBG_20664 ^@ http://purl.uniprot.org/uniprot/A8XYB4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC25 family.|||Endomembrane system|||Interacts (via cytoplasmic region) with ILK. http://togogenome.org/gene/6238:CBG_23516 ^@ http://purl.uniprot.org/uniprot/A8Y3Q8 ^@ Similarity ^@ Belongs to the peptidase C13 family. http://togogenome.org/gene/6238:CBG_13539 ^@ http://purl.uniprot.org/uniprot/A8XI49 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/6238:CBG_04224 ^@ http://purl.uniprot.org/uniprot/Q61WW9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin family. ARP3 subfamily.|||Component of the Arp2/3 complex.|||Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).|||cytoskeleton http://togogenome.org/gene/6238:CBG_07007 ^@ http://purl.uniprot.org/uniprot/A8X3X7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_05577 ^@ http://purl.uniprot.org/uniprot/A8X068 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_08027 ^@ http://purl.uniprot.org/uniprot/A8X5M0 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_13105 ^@ http://purl.uniprot.org/uniprot/A8XH36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I33 family.|||Secreted http://togogenome.org/gene/6238:CBG_15955 ^@ http://purl.uniprot.org/uniprot/Q614K9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 1 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/6238:CBG_03161 ^@ http://purl.uniprot.org/uniprot/A8WSN1 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/6238:CBG_19878 ^@ http://purl.uniprot.org/uniprot/A8XWM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty-acid and retinol-binding protein (FARBP) family.|||Secreted http://togogenome.org/gene/6238:CBG_17074 ^@ http://purl.uniprot.org/uniprot/A8XQF8 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/6238:CBG_03776 ^@ http://purl.uniprot.org/uniprot/A8WWP8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_13377 ^@ http://purl.uniprot.org/uniprot/A8XHW9 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/6238:CBG_08012 ^@ http://purl.uniprot.org/uniprot/A8X5K8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_22375 ^@ http://purl.uniprot.org/uniprot/A8Y238 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/6238:CBG_18871 ^@ http://purl.uniprot.org/uniprot/A8XU89 ^@ Similarity|||Subunit ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.|||Homodimer. http://togogenome.org/gene/6238:CBG_13395 ^@ http://purl.uniprot.org/uniprot/A8XHV3 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic GSH synthase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/6238:CBG_04078 ^@ http://purl.uniprot.org/uniprot/A8WW58 ^@ Similarity ^@ Belongs to the MYST (SAS/MOZ) family. http://togogenome.org/gene/6238:CBG_14284 ^@ http://purl.uniprot.org/uniprot/A8XJP0 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/6238:CBG_23105 ^@ http://purl.uniprot.org/uniprot/Q60MK8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Hydrolase that deubiquitinates target proteins.|||Nucleus http://togogenome.org/gene/6238:CBG_16676 ^@ http://purl.uniprot.org/uniprot/A8XPA6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL18 family. http://togogenome.org/gene/6238:CBG_08167 ^@ http://purl.uniprot.org/uniprot/A8X5Z1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_21805 ^@ http://purl.uniprot.org/uniprot/A8Y0U8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_16718 ^@ http://purl.uniprot.org/uniprot/A8XPP0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_15185 ^@ http://purl.uniprot.org/uniprot/Q616Q2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer; composed of 3 copies of ddp-1/tim-8 and 3 copies of tin-13/tim-13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of tim-22 (By similarity).|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The ddp-1/tim-8-tim-13 complex mediates the import of some proteins while the predominant tim-9/tin-9.1-tim-10/tin-10 70 kDa complex mediates the import of much more proteins.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of ddp-1/tim-8 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane. http://togogenome.org/gene/6238:CBG_19422 ^@ http://purl.uniprot.org/uniprot/A8XVK7 ^@ Similarity ^@ Belongs to the RuvB family. http://togogenome.org/gene/6238:CBG_23137 ^@ http://purl.uniprot.org/uniprot/A8Y4M2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_19427 ^@ http://purl.uniprot.org/uniprot/A8XVL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||cis-Golgi network http://togogenome.org/gene/6238:CBG_10464 ^@ http://purl.uniprot.org/uniprot/A8XBA0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_12362 ^@ http://purl.uniprot.org/uniprot/A8XF90 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/6238:CBG_14399 ^@ http://purl.uniprot.org/uniprot/A8XJX2 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_12003 ^@ http://purl.uniprot.org/uniprot/A8XEB6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/6238:CBG_06579 ^@ http://purl.uniprot.org/uniprot/A8X2K8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_15261 ^@ http://purl.uniprot.org/uniprot/A8XLJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_11654 ^@ http://purl.uniprot.org/uniprot/A8XDQ7 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. http://togogenome.org/gene/6238:CBG_18597 ^@ http://purl.uniprot.org/uniprot/A8XTN8 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/6238:CBG_01651 ^@ http://purl.uniprot.org/uniprot/A8WR60 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. http://togogenome.org/gene/6238:CBG_06640 ^@ http://purl.uniprot.org/uniprot/A8X2Q8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_24278 ^@ http://purl.uniprot.org/uniprot/A8WKD1 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/6238:CBG_00740 ^@ http://purl.uniprot.org/uniprot/A8WN63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM138 family.|||Membrane|||Required for ciliogenesis.|||Vacuole membrane http://togogenome.org/gene/6238:CBG_10985 ^@ http://purl.uniprot.org/uniprot/A8XBZ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta-catenin family.|||Cell junction|||Cytoplasm|||Interacts with apr-1, axl-1, daf-16, lin-23, and pop-1 (via acidic region in N-terminus 1-44). Interacts (via ARM repeats) with pry-1 (By similarity).|||Membrane|||Nucleus|||Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectodermal cell P12 specification, movement, body length, male tail development and dauer induction. Functionally redundant to wrm-1 and hmp-2 (By similarity). http://togogenome.org/gene/6238:CBG_17261 ^@ http://purl.uniprot.org/uniprot/A8XQG8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/6238:CBG_16756 ^@ http://purl.uniprot.org/uniprot/A8XPR4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_13493 ^@ http://purl.uniprot.org/uniprot/A8XI08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/6238:CBG_12232 ^@ http://purl.uniprot.org/uniprot/A8XEX7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_21991 ^@ http://purl.uniprot.org/uniprot/A8Y1A5 ^@ Similarity ^@ Belongs to the glycosyltransferase 92 family. http://togogenome.org/gene/6238:CBG_14199 ^@ http://purl.uniprot.org/uniprot/Q619N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histidine acid phosphatase family.|||Membrane http://togogenome.org/gene/6238:CBG_10084 ^@ http://purl.uniprot.org/uniprot/A8XAC6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BAF family.|||DNA-binding protein which plays an essential role in nuclear envelope formation. Required for normal chromosome segregation during mitosis. Associates with the nuclear lamina via its interaction with LEM domain containing proteins emr-1 and lem-2 (By similarity).|||Interacts with emr-1 and lem-2. Interacts with lem-4l, leading to decreased phosphorylation by VRK1 and promoting dephosphorylation by protein phosphatase 2A (PP2A) (By similarity).|||Nucleus|||Phosphorylated by vrk-1. Phosphorylation by vrk-1 in mitosis is essential to achieve correct timing of recruitment of nuclear envelope components during nuclear envelope assembly. Dephosphorylated by protein phosphatase 2A (PP2A) following interaction with lem-4l during mitotic exit, leading to mitotic nuclear envelope reassembly (By similarity). http://togogenome.org/gene/6238:CBG_05342 ^@ http://purl.uniprot.org/uniprot/A8WZM5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_00364 ^@ http://purl.uniprot.org/uniprot/A8WMX1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_01465 ^@ http://purl.uniprot.org/uniprot/A8WQM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/6238:CBG_10069 ^@ http://purl.uniprot.org/uniprot/A8XAB1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_01004 ^@ http://purl.uniprot.org/uniprot/Q626F4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS1/PSF1 family.|||Component of the GINS complex which is a heterotetramer of gins1, gins2, gins3 and gins4.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication. http://togogenome.org/gene/6238:CBG_04265 ^@ http://purl.uniprot.org/uniprot/A8WX33 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/6238:CBG_13858 ^@ http://purl.uniprot.org/uniprot/A8XIV5 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/6238:CBG_04201 ^@ http://purl.uniprot.org/uniprot/A8WWE8 ^@ Function|||Similarity ^@ Belongs to the ARPC5 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. http://togogenome.org/gene/6238:CBG_22669 ^@ http://purl.uniprot.org/uniprot/A8Y2T9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic13 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_20410 ^@ http://purl.uniprot.org/uniprot/A8XXQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL52 family.|||Mitochondrion http://togogenome.org/gene/6238:CBG_16654 ^@ http://purl.uniprot.org/uniprot/A8XP86 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_23796 ^@ http://purl.uniprot.org/uniprot/A8WJB2 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/6238:CBG_07923 ^@ http://purl.uniprot.org/uniprot/A8X5D5 ^@ Similarity ^@ Belongs to the WD repeat SMU1 family. http://togogenome.org/gene/6238:CBG_20119 ^@ http://purl.uniprot.org/uniprot/A8XX47 ^@ Similarity ^@ Belongs to the cytochrome c oxidase subunit 6c family. http://togogenome.org/gene/6238:CBG_20879 ^@ http://purl.uniprot.org/uniprot/A8XYV2 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/6238:CBG_00899 ^@ http://purl.uniprot.org/uniprot/A8WPD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARV1 family.|||Endoplasmic reticulum membrane|||Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.|||Membrane http://togogenome.org/gene/6238:CBG_04018 ^@ http://purl.uniprot.org/uniprot/A8WW00 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/6238:CBG_21347 ^@ http://purl.uniprot.org/uniprot/A8XZV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nicastrin family.|||Membrane http://togogenome.org/gene/6238:CBG_19562 ^@ http://purl.uniprot.org/uniprot/A8XVW7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_23180 ^@ http://purl.uniprot.org/uniprot/A8Y4I4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6238:CBG_22088 ^@ http://purl.uniprot.org/uniprot/A8Y1H9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6238:CBG_06232 ^@ http://purl.uniprot.org/uniprot/A8X0K9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DDB1 family.|||Cytoplasm|||Nucleus|||Plays a role in DNA repair. May be a component of an E3 ubiquitin-protein ligase which promotes histone ubiquitination in response to UV irradiation. Histone ubiquitination may be important for subsequent DNA repair. http://togogenome.org/gene/6238:CBG_23438 ^@ http://purl.uniprot.org/uniprot/G2J6C3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_06503 ^@ http://purl.uniprot.org/uniprot/A8X2D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_04173 ^@ http://purl.uniprot.org/uniprot/A8WWC2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL17 family. http://togogenome.org/gene/6238:CBG_08593 ^@ http://purl.uniprot.org/uniprot/A8X716 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_03659 ^@ http://purl.uniprot.org/uniprot/A8WVJ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_24141 ^@ http://purl.uniprot.org/uniprot/A8WK25 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_21019 ^@ http://purl.uniprot.org/uniprot/A8XZ66 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAD kinase family.|||Homodimer.|||Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.|||Mitochondrion http://togogenome.org/gene/6238:CBG_01947 ^@ http://purl.uniprot.org/uniprot/Q622Z7 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.|||Specifically phosphorylates the activated forms of G protein-coupled receptors. http://togogenome.org/gene/6238:CBG_19242 ^@ http://purl.uniprot.org/uniprot/A8XV60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_08257 ^@ http://purl.uniprot.org/uniprot/A8X656 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/6238:CBG_16161 ^@ http://purl.uniprot.org/uniprot/A8XNZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_07651 ^@ http://purl.uniprot.org/uniprot/A8X4D2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMDT1/EMRE family.|||Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.|||Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_16983 ^@ http://purl.uniprot.org/uniprot/G2J6A4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_23108 ^@ http://purl.uniprot.org/uniprot/A8Y4P2 ^@ Function|||Similarity ^@ Belongs to the ATPase d subunit family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. http://togogenome.org/gene/6238:CBG_09671 ^@ http://purl.uniprot.org/uniprot/A8X8I3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_03880 ^@ http://purl.uniprot.org/uniprot/A8WWZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INCENP family.|||Nucleus|||spindle http://togogenome.org/gene/6238:CBG_03435 ^@ http://purl.uniprot.org/uniprot/A8WV22 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. http://togogenome.org/gene/6238:CBG_08757 ^@ http://purl.uniprot.org/uniprot/A8X7B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Membrane http://togogenome.org/gene/6238:CBG_00257 ^@ http://purl.uniprot.org/uniprot/A8WMK4 ^@ Similarity ^@ Belongs to the GST superfamily. Zeta family. http://togogenome.org/gene/6238:CBG_17190 ^@ http://purl.uniprot.org/uniprot/A8XQL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/6238:CBG_18338 ^@ http://purl.uniprot.org/uniprot/A8XSG9 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. http://togogenome.org/gene/6238:CBG_12064 ^@ http://purl.uniprot.org/uniprot/A8XEG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs (By similarity).|||Belongs to the ARS2 family.|||Nucleus http://togogenome.org/gene/6238:CBG_03552 ^@ http://purl.uniprot.org/uniprot/A8WVB5 ^@ Function ^@ Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. http://togogenome.org/gene/6238:CBG_09943 ^@ http://purl.uniprot.org/uniprot/A8XA04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_00686 ^@ http://purl.uniprot.org/uniprot/A8WNA6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_23345 ^@ http://purl.uniprot.org/uniprot/A8Y452 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/6238:CBG_19995 ^@ http://purl.uniprot.org/uniprot/A8XWW4 ^@ Function|||Similarity|||Subunit ^@ Acts as a Ras effector and participates in MAPK pathway activation. Probably acts as a regulatory subunit of protein phosphatase that specifically dephosphorylates Raf kinase and stimulates Raf activity at specialized signaling complexes upon Ras activation. Required for vulval development. Involved in fluid homeostasis. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine.|||Belongs to the SHOC2 family.|||Interacts with let-60. http://togogenome.org/gene/6238:CBG_07946 ^@ http://purl.uniprot.org/uniprot/A8X5F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/6238:CBG_13078 ^@ http://purl.uniprot.org/uniprot/A8XH13 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_00233 ^@ http://purl.uniprot.org/uniprot/A8WMI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/6238:CBG_11281 ^@ http://purl.uniprot.org/uniprot/A8XDD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MPDU1 (TC 2.A.43.3) family.|||Membrane http://togogenome.org/gene/6238:CBG_19289 ^@ http://purl.uniprot.org/uniprot/A8XV98 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/6238:CBG_05118 ^@ http://purl.uniprot.org/uniprot/A8WZ78 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_14465 ^@ http://purl.uniprot.org/uniprot/A8XK02 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/6238:CBG_24315 ^@ http://purl.uniprot.org/uniprot/A8WKF8 ^@ Similarity ^@ Belongs to the ANP32 family. http://togogenome.org/gene/6238:CBG_11178 ^@ http://purl.uniprot.org/uniprot/A8XCM4 ^@ Similarity ^@ Belongs to the acetyl-CoA hydrolase/transferase family. http://togogenome.org/gene/6238:CBG_16310 ^@ http://purl.uniprot.org/uniprot/A8XNQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane http://togogenome.org/gene/6238:CBG_10001 ^@ http://purl.uniprot.org/uniprot/A8XA52 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||Vacuole membrane http://togogenome.org/gene/6238:CBG_12819 ^@ http://purl.uniprot.org/uniprot/A8XFP4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family. http://togogenome.org/gene/6238:CBG_09828 ^@ http://purl.uniprot.org/uniprot/A8X9R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PHAX family.|||Cytoplasm http://togogenome.org/gene/6238:CBG_01005 ^@ http://purl.uniprot.org/uniprot/A8WP46 ^@ Function|||Similarity ^@ Belongs to the ATPase F chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. http://togogenome.org/gene/6238:CBG_01236 ^@ http://purl.uniprot.org/uniprot/A8WPX1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_19778 ^@ http://purl.uniprot.org/uniprot/A8XWC1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.|||nucleolus http://togogenome.org/gene/6238:CBG_05356 ^@ http://purl.uniprot.org/uniprot/A8WZN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_23201 ^@ http://purl.uniprot.org/uniprot/A8Y4G9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_06446 ^@ http://purl.uniprot.org/uniprot/A8X285 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family. http://togogenome.org/gene/6238:CBG_19766 ^@ http://purl.uniprot.org/uniprot/A8XWD2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_21262 ^@ http://purl.uniprot.org/uniprot/A8XZQ2 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_20995 ^@ http://purl.uniprot.org/uniprot/G2J697 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_05932 ^@ http://purl.uniprot.org/uniprot/A8X1A9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_04324 ^@ http://purl.uniprot.org/uniprot/A8WX92 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_04567 ^@ http://purl.uniprot.org/uniprot/A8WXY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/6238:CBG_12089 ^@ http://purl.uniprot.org/uniprot/A8XEJ0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family. http://togogenome.org/gene/6238:CBG_06089 ^@ http://purl.uniprot.org/uniprot/P51558 ^@ Function ^@ Involved in cuticle function and is essential for normal morphological development. http://togogenome.org/gene/6238:CBG_19185 ^@ http://purl.uniprot.org/uniprot/A8XV10 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/6238:CBG_02887 ^@ http://purl.uniprot.org/uniprot/A8WTA4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/6238:CBG_13522 ^@ http://purl.uniprot.org/uniprot/A8XI34 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/6238:CBG_17574 ^@ http://purl.uniprot.org/uniprot/A8XR99 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_13136 ^@ http://purl.uniprot.org/uniprot/Q61C05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dullard family.|||Membrane|||Serine/threonine protein phosphatase that may dephosphorylate and activate lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol (By similarity). http://togogenome.org/gene/6238:CBG_03774 ^@ http://purl.uniprot.org/uniprot/G2J6C3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/6238:CBG_11321 ^@ http://purl.uniprot.org/uniprot/G2J687 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. http://togogenome.org/gene/6238:CBG_16621 ^@ http://purl.uniprot.org/uniprot/A8XPL8 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/6238:CBG_23103 ^@ http://purl.uniprot.org/uniprot/A8Y4P7 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/6238:CBG_02500 ^@ http://purl.uniprot.org/uniprot/A8WU64 ^@ Similarity ^@ Belongs to the LECT2/MIM-1 family. http://togogenome.org/gene/6238:CBG_24614 ^@ http://purl.uniprot.org/uniprot/A8WL29 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_24373 ^@ http://purl.uniprot.org/uniprot/A8WKK1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_17857 ^@ http://purl.uniprot.org/uniprot/A8XRX6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_11594 ^@ http://purl.uniprot.org/uniprot/A8XDK9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2). Component of the SAGA transcription coactivator-HAT complex. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.|||nucleoplasm http://togogenome.org/gene/6238:CBG_06959 ^@ http://purl.uniprot.org/uniprot/A8X419 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit L family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/6238:CBG_04602 ^@ http://purl.uniprot.org/uniprot/A8WY12 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_19782 ^@ http://purl.uniprot.org/uniprot/A8XWB7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS28 family.|||Component of the ESCRT-I complex (endosomal sorting complex required for transport I).|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process.|||Endosome http://togogenome.org/gene/6238:CBG_21313 ^@ http://purl.uniprot.org/uniprot/A8XZT5 ^@ Similarity ^@ Belongs to the RRM RBM42 family. http://togogenome.org/gene/6238:CBG_18037 ^@ http://purl.uniprot.org/uniprot/A8XSW1 ^@ Similarity ^@ Belongs to the proteasome subunit S5B/HSM3 family. http://togogenome.org/gene/6238:CBG_04016 ^@ http://purl.uniprot.org/uniprot/A8WVZ8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6238:CBG_05232 ^@ http://purl.uniprot.org/uniprot/A8WZF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI inositol-deacylase family.|||Endoplasmic reticulum membrane|||Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins. http://togogenome.org/gene/6238:CBG_09395 ^@ http://purl.uniprot.org/uniprot/A8X970 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_01255 ^@ http://purl.uniprot.org/uniprot/A8WPY9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_20564 ^@ http://purl.uniprot.org/uniprot/A8XY34 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/6238:CBG_18435 ^@ http://purl.uniprot.org/uniprot/A8XTB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/6238:CBG_06101 ^@ http://purl.uniprot.org/uniprot/A8X0W6 ^@ Similarity ^@ Belongs to the complex I NDUFB6 subunit family. http://togogenome.org/gene/6238:CBG_08036 ^@ http://purl.uniprot.org/uniprot/A8X5M6 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/6238:CBG_00262 ^@ http://purl.uniprot.org/uniprot/A8WMK7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_11103 ^@ http://purl.uniprot.org/uniprot/A8XCE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELOF1 family.|||Nucleus|||Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. http://togogenome.org/gene/6238:CBG_02104 ^@ http://purl.uniprot.org/uniprot/A8WRZ9 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/6238:CBG_08648 ^@ http://purl.uniprot.org/uniprot/A8X6W7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SWEET sugar transporter family.|||Cell membrane|||Golgi apparatus membrane|||Mediates sugar transport across membranes.|||Membrane http://togogenome.org/gene/6238:CBG_12062 ^@ http://purl.uniprot.org/uniprot/A8XEG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/6238:CBG_12945 ^@ http://purl.uniprot.org/uniprot/G2J6S2 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/6238:CBG_23144 ^@ http://purl.uniprot.org/uniprot/E3CU94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Spartan family.|||Chromosome|||Nucleus http://togogenome.org/gene/6238:CBG_03731 ^@ http://purl.uniprot.org/uniprot/A8WWK7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_22842 ^@ http://purl.uniprot.org/uniprot/A8Y366 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_11892 ^@ http://purl.uniprot.org/uniprot/A8XE89 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.|||Belongs to the NMD3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/6238:CBG_09422 ^@ http://purl.uniprot.org/uniprot/A8X952 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_20958 ^@ http://purl.uniprot.org/uniprot/A8XZ17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sre family.|||Membrane http://togogenome.org/gene/6238:CBG_08414 ^@ http://purl.uniprot.org/uniprot/A8X6I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS25 family.|||Mitochondrion http://togogenome.org/gene/6238:CBG_10499 ^@ http://purl.uniprot.org/uniprot/A8XAY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/6238:CBG_14136 ^@ http://purl.uniprot.org/uniprot/P32810 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/6238:CBG_06866 ^@ http://purl.uniprot.org/uniprot/A8X389 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/6238:CBG_04354 ^@ http://purl.uniprot.org/uniprot/A8WXC2 ^@ Similarity ^@ Belongs to the peptidase M13 family. http://togogenome.org/gene/6238:CBG_19685 ^@ http://purl.uniprot.org/uniprot/A8XW70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/6238:CBG_21068 ^@ http://purl.uniprot.org/uniprot/A8XZ98 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/6238:CBG_12546 ^@ http://purl.uniprot.org/uniprot/A8XG05 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/6238:CBG_12012 ^@ http://purl.uniprot.org/uniprot/A8XEC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_01490 ^@ http://purl.uniprot.org/uniprot/A8WQK4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP14 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm|||Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. http://togogenome.org/gene/6238:CBG_09048 ^@ http://purl.uniprot.org/uniprot/A8X7X7 ^@ Similarity ^@ Belongs to the dynactin subunit 2 family. http://togogenome.org/gene/6238:CBG_15782 ^@ http://purl.uniprot.org/uniprot/A8XMS8 ^@ Subunit ^@ Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_21369 ^@ http://purl.uniprot.org/uniprot/A8XZY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EAF7 family.|||Nucleus http://togogenome.org/gene/6238:CBG_01820 ^@ http://purl.uniprot.org/uniprot/A8WQQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/6238:CBG_09411 ^@ http://purl.uniprot.org/uniprot/A8X959 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_07689 ^@ http://purl.uniprot.org/uniprot/A8X4A4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_06568 ^@ http://purl.uniprot.org/uniprot/A8X2J9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May be involved in iron transport and iron homeostasis.|||Membrane http://togogenome.org/gene/6238:CBG_05683 ^@ http://purl.uniprot.org/uniprot/A8X0F7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_20346 ^@ http://purl.uniprot.org/uniprot/A8XXL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/6238:CBG_17397 ^@ http://purl.uniprot.org/uniprot/A8XQZ0 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/6238:CBG_00263 ^@ http://purl.uniprot.org/uniprot/A8WMK8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_19226 ^@ http://purl.uniprot.org/uniprot/A8XV46 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/6238:CBG_07646 ^@ http://purl.uniprot.org/uniprot/A8X4D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum-Golgi intermediate compartment membrane http://togogenome.org/gene/6238:CBG_14711 ^@ http://purl.uniprot.org/uniprot/A8XKI2 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/6238:CBG_07608 ^@ http://purl.uniprot.org/uniprot/A8X4G3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/6238:CBG_20988 ^@ http://purl.uniprot.org/uniprot/A8XZ41 ^@ Similarity ^@ Belongs to the nematode receptor-like protein srg family. http://togogenome.org/gene/6238:CBG_07987 ^@ http://purl.uniprot.org/uniprot/A8X5I4 ^@ Similarity ^@ Belongs to the LSM14 family. http://togogenome.org/gene/6238:CBG_03817 ^@ http://purl.uniprot.org/uniprot/A8WWT7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48A family.|||Binds 1 zinc ion per subunit.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Proteolytically removes the C-terminal three residues of farnesylated proteins. http://togogenome.org/gene/6238:CBG_19676 ^@ http://purl.uniprot.org/uniprot/A8XW61 ^@ Cofactor|||Function ^@ Accepts electrons from ETF and reduces ubiquinone.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/6238:CBG_19223 ^@ http://purl.uniprot.org/uniprot/A8XV43 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.|||Monomer.|||Nucleus http://togogenome.org/gene/6238:CBG_02224 ^@ http://purl.uniprot.org/uniprot/A8WS86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP40 family.|||Cytoplasm|||nucleolus http://togogenome.org/gene/6238:CBG_03002 ^@ http://purl.uniprot.org/uniprot/A8WT09 ^@ Similarity ^@ Belongs to the NADP-dependent oxidoreductase L4BD family. http://togogenome.org/gene/6238:CBG_14799 ^@ http://purl.uniprot.org/uniprot/A8XKP9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_01802 ^@ http://purl.uniprot.org/uniprot/A8WQS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_08996 ^@ http://purl.uniprot.org/uniprot/A8X820 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus http://togogenome.org/gene/6238:CBG_08511 ^@ http://purl.uniprot.org/uniprot/A8X6R0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Membrane|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. http://togogenome.org/gene/6238:CBG_03721 ^@ http://purl.uniprot.org/uniprot/A8WWJ6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/6238:CBG_15257 ^@ http://purl.uniprot.org/uniprot/A8XLJ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex.|||In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.|||Nucleus http://togogenome.org/gene/6238:CBG_10085 ^@ http://purl.uniprot.org/uniprot/A8XAC7 ^@ Function|||Similarity ^@ Belongs to the AB hydrolase superfamily.|||Demethylates proteins that have been reversibly carboxymethylated. http://togogenome.org/gene/6238:CBG_12956 ^@ http://purl.uniprot.org/uniprot/A8XGR5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/6238:CBG_13533 ^@ http://purl.uniprot.org/uniprot/A8XI43 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/6238:CBG_04460 ^@ http://purl.uniprot.org/uniprot/A8WXM1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Cytoplasm|||Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate. Highest catalytic efficiency for D-Glu followed by D-Asp and NMDA. May play a role in the egg-laying events and early development of the worm, in addition to quality control of the germ cells.|||The conserved active site Tyr residue in position 221 is replaced by a Phe. http://togogenome.org/gene/6238:CBG_21997 ^@ http://purl.uniprot.org/uniprot/G2J721 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_11771 ^@ http://purl.uniprot.org/uniprot/A8XE05 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/6238:CBG_09364 ^@ http://purl.uniprot.org/uniprot/A8X996 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Late endosome membrane http://togogenome.org/gene/6238:CBG_09821 ^@ http://purl.uniprot.org/uniprot/A8X9Q6 ^@ Similarity ^@ Belongs to the TBCC family. http://togogenome.org/gene/6238:CBG_09373 ^@ http://purl.uniprot.org/uniprot/A8X989 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_07785 ^@ http://purl.uniprot.org/uniprot/A8X433 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_04239 ^@ http://purl.uniprot.org/uniprot/A8WX09 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/6238:CBG_10906 ^@ http://purl.uniprot.org/uniprot/A8XC87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase g subunit family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. http://togogenome.org/gene/6238:CBG_15739 ^@ http://purl.uniprot.org/uniprot/A8XMN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/6238:CBG_11957 ^@ http://purl.uniprot.org/uniprot/A8XEN9 ^@ Similarity ^@ Belongs to the argonaute family. http://togogenome.org/gene/6238:CBG_17822 ^@ http://purl.uniprot.org/uniprot/A8XRU8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_17741 ^@ http://purl.uniprot.org/uniprot/A8XRE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunit 4 family.|||cell cortex|||centrosome|||sarcomere|||stress fiber http://togogenome.org/gene/6238:CBG_07668 ^@ http://purl.uniprot.org/uniprot/A8X4B8 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/6238:CBG_02167 ^@ http://purl.uniprot.org/uniprot/A8WS37 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/6238:CBG_16650 ^@ http://purl.uniprot.org/uniprot/A8XP82 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/6238:CBG_01117 ^@ http://purl.uniprot.org/uniprot/A8WPL4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_05988 ^@ http://purl.uniprot.org/uniprot/A8X163 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HRG family.|||Membrane http://togogenome.org/gene/6238:CBG_16733 ^@ http://purl.uniprot.org/uniprot/A8XPQ3 ^@ Similarity ^@ Belongs to the cytidylyltransferase family. http://togogenome.org/gene/6238:CBG_01390 ^@ http://purl.uniprot.org/uniprot/A8WQA9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_25151 ^@ http://purl.uniprot.org/uniprot/B0K086 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRIPT family.|||Cytoplasm http://togogenome.org/gene/6238:CBG_12250 ^@ http://purl.uniprot.org/uniprot/A8XF34 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. http://togogenome.org/gene/6238:CBG_01493 ^@ http://purl.uniprot.org/uniprot/A8WQK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/6238:CBG_23568 ^@ http://purl.uniprot.org/uniprot/A8WIU9 ^@ Similarity ^@ Belongs to the UQCRB/QCR7 family. http://togogenome.org/gene/6238:CBG_23152 ^@ http://purl.uniprot.org/uniprot/A8Y4K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/6238:CBG_02140 ^@ http://purl.uniprot.org/uniprot/Q622K8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||Cytoplasm|||Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). http://togogenome.org/gene/6238:CBG_07587 ^@ http://purl.uniprot.org/uniprot/A8X4H9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TIKI family.|||Cell membrane|||Divalent metal cations. Mn(2+) or Co(2+).|||Membrane|||Metalloprotease that acts as a negative regulator of the Wnt signaling pathway. http://togogenome.org/gene/6238:CBG_15273 ^@ http://purl.uniprot.org/uniprot/A8XLI3 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_00562 ^@ http://purl.uniprot.org/uniprot/A8WNK9 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_20281 ^@ http://purl.uniprot.org/uniprot/A8XXG7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MoaE family. MOCS2B subfamily.|||Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.|||Cytoplasm|||Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits. http://togogenome.org/gene/6238:CBG_23171 ^@ http://purl.uniprot.org/uniprot/A8Y4J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/6238:CBG_03711 ^@ http://purl.uniprot.org/uniprot/A8WWI7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_14479 ^@ http://purl.uniprot.org/uniprot/A8XK11 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/6238:CBG_03930 ^@ http://purl.uniprot.org/uniprot/A8WVS5 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/6238:CBG_13827 ^@ http://purl.uniprot.org/uniprot/A8XIS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/6238:CBG_05238 ^@ http://purl.uniprot.org/uniprot/A8WZG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.|||Membrane http://togogenome.org/gene/6238:CBG_07897 ^@ http://purl.uniprot.org/uniprot/A8X5D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/6238:CBG_22101 ^@ http://purl.uniprot.org/uniprot/A8Y1J0 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. http://togogenome.org/gene/6238:CBG_03233 ^@ http://purl.uniprot.org/uniprot/Q61Z75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).|||Belongs to the complex I NDUFB2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_05114 ^@ http://purl.uniprot.org/uniprot/Q61UX1 ^@ Function|||Similarity ^@ Belongs to the NAC-alpha family.|||May promote appropriate targeting of ribosome-nascent polypeptide complexes. http://togogenome.org/gene/6238:CBG_17678 ^@ http://purl.uniprot.org/uniprot/Q60ZS1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the shugoshin family.|||Nucleus|||Plays a central role in chromosome cohesion during cell division by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms.|||centromere http://togogenome.org/gene/6238:CBG_16981 ^@ http://purl.uniprot.org/uniprot/A8XQ69 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_12193 ^@ http://purl.uniprot.org/uniprot/A8XF10 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/6238:CBG_06069 ^@ http://purl.uniprot.org/uniprot/A8X0Z3 ^@ Similarity ^@ Belongs to the DNAJC25 family. http://togogenome.org/gene/6238:CBG_17279 ^@ http://purl.uniprot.org/uniprot/A8XQR4 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/6238:CBG_02871 ^@ http://purl.uniprot.org/uniprot/A8WTB8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/6238:CBG_03259 ^@ http://purl.uniprot.org/uniprot/A8WSF9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_07603 ^@ http://purl.uniprot.org/uniprot/A8X4G6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_13043 ^@ http://purl.uniprot.org/uniprot/A8XGY2 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_12085 ^@ http://purl.uniprot.org/uniprot/A8XEI6 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Monomer. http://togogenome.org/gene/6238:CBG_02839 ^@ http://purl.uniprot.org/uniprot/A8WTE5 ^@ Similarity ^@ Belongs to the proteasome subunit S14 family. http://togogenome.org/gene/6238:CBG_13401 ^@ http://purl.uniprot.org/uniprot/A8XHU7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.|||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. http://togogenome.org/gene/6238:CBG_03570 ^@ http://purl.uniprot.org/uniprot/A8WVD0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the syntaxin family.|||Cell membrane|||Interacts (via N-terminus, in open or in closed conformation) with unc-18; the interaction is direct (By similarity). Interaction in open conformation with unc-18 promotes synaptic vesicle docking and tethering (By similarity). Interaction via N-terminus with unc-18 mediates the secretion of the neurotransmitter acetylcholine from cholinergic motor neurons (By similarity). Interaction with unc-18 is reduced in the presence of unc-13 (By similarity).|||Perikaryon|||Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation (By similarity). Plays a role in synaptic vesicle docking and tethering through its association with unc-18 (By similarity). Through binding to unc-18 mediates the release of the neurotransmitter acetylcholine from cholinergic motor neurons, and thereby promotes locomotory behaviors (By similarity). Essential for embryonic viability and development (By similarity). Has a role in dauer formation and adult life span. Required for locomotion (By similarity). Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt (By similarity).|||axon|||dendrite http://togogenome.org/gene/6238:CBG_06423 ^@ http://purl.uniprot.org/uniprot/A8X271 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/6238:CBG_04076 ^@ http://purl.uniprot.org/uniprot/A8WW56 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/6238:CBG_22936 ^@ http://purl.uniprot.org/uniprot/A8Y3M2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins such as unc-5 and mig-21. Mediates the attachment of alpha-mannose in C-C linkage to the C2 of the indole ring of tryptophan. C-mannosylation takes place in the endoplasmic reticulum and frequently found in thrombospondin (TSP) type-1 repeats and in the WSXWS motif of type I cytokine receptors. Required to orient neuroblasts QL and QR correctly on the anterior/posterior (A/P) axis: QL and QR are born in the same A/P position, but polarize and migrate left/right asymmetrically, QL migrates toward the posterior and QR migrates toward the anterior. Required with unc-40 to express mab-5 correctly in the Q cell descendants (By similarity).|||Endoplasmic reticulum membrane http://togogenome.org/gene/6238:CBG_23008 ^@ http://purl.uniprot.org/uniprot/A8Y3G4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/6238:CBG_06812 ^@ http://purl.uniprot.org/uniprot/A8X348 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty-acid and retinol-binding protein (FARBP) family.|||Secreted http://togogenome.org/gene/6238:CBG_15145 ^@ http://purl.uniprot.org/uniprot/A8XLU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DSS1/SEM1 family.|||Cytoplasm|||Nucleus|||Part of the 26S proteasome.|||Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis. Has an essential role in oogenesis and larval growth. Required for intestinal function and default lifespan (By similarity). http://togogenome.org/gene/6238:CBG_22844 ^@ http://purl.uniprot.org/uniprot/A8Y368 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/6238:CBG_07654 ^@ http://purl.uniprot.org/uniprot/A8X4C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel flower family.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/6238:CBG_15381 ^@ http://purl.uniprot.org/uniprot/A8XM25 ^@ Similarity ^@ Belongs to the acid ceramidase family. http://togogenome.org/gene/6238:CBG_06683 ^@ http://purl.uniprot.org/uniprot/A8X2U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode transthyretin-like family.|||Secreted http://togogenome.org/gene/6238:CBG_09085 ^@ http://purl.uniprot.org/uniprot/A8X7U3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/6238:CBG_13457 ^@ http://purl.uniprot.org/uniprot/A8XHQ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/6238:CBG_17688 ^@ http://purl.uniprot.org/uniprot/A8XRI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MVB12 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/6238:CBG_00356 ^@ http://purl.uniprot.org/uniprot/A8WMW5 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_10116 ^@ http://purl.uniprot.org/uniprot/A8XAF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cuticular collagen family.|||Membrane|||basement membrane http://togogenome.org/gene/6238:CBG_03481 ^@ http://purl.uniprot.org/uniprot/A8WV62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcriptional coactivator PC4 family.|||Nucleus http://togogenome.org/gene/6238:CBG_06974 ^@ http://purl.uniprot.org/uniprot/A8X406 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/6238:CBG_22199 ^@ http://purl.uniprot.org/uniprot/A8Y1S2 ^@ Cofactor ^@ Binds 2 Cu(2+) ions per subunit. http://togogenome.org/gene/6238:CBG_02935 ^@ http://purl.uniprot.org/uniprot/A8WT64 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM22 complex.|||Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/6238:CBG_19683 ^@ http://purl.uniprot.org/uniprot/A8XW68 ^@ Similarity ^@ Belongs to the complex I 49 kDa subunit family. http://togogenome.org/gene/6238:CBG_22800 ^@ http://purl.uniprot.org/uniprot/A8Y2W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTX family.|||Nucleus http://togogenome.org/gene/6238:CBG_15760 ^@ http://purl.uniprot.org/uniprot/A8XMQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/6238:CBG_13240 ^@ http://purl.uniprot.org/uniprot/A8XHD7 ^@ Similarity|||Subunit ^@ Belongs to the cuticular collagen family.|||Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links. http://togogenome.org/gene/6238:CBG_02552 ^@ http://purl.uniprot.org/uniprot/A8WU22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/6238:CBG_00848 ^@ http://purl.uniprot.org/uniprot/A8WPG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/6238:CBG_14378 ^@ http://purl.uniprot.org/uniprot/A8XJV4 ^@ Similarity ^@ Belongs to the TAF11 family. http://togogenome.org/gene/6238:CBG_20962 ^@ http://purl.uniprot.org/uniprot/A8XZ20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nematode receptor-like protein sre family.|||Membrane http://togogenome.org/gene/6238:CBG_20706 ^@ http://purl.uniprot.org/uniprot/A8XYF4 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/6238:CBG_21817 ^@ http://purl.uniprot.org/uniprot/A8Y0W0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm|||Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. http://togogenome.org/gene/6238:CBG_10878 ^@ http://purl.uniprot.org/uniprot/A8XC71 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 63 family.