http://togogenome.org/gene/8083:LOC102228390 ^@ http://purl.uniprot.org/uniprot/M4AXG7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:ypel1 ^@ http://purl.uniprot.org/uniprot/A0A3B5RCH8 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/8083:LOC102233992 ^@ http://purl.uniprot.org/uniprot/M3ZYE8 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/8083:pde9a ^@ http://purl.uniprot.org/uniprot/M4A375 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/8083:LOC102230865 ^@ http://purl.uniprot.org/uniprot/M4ATP1 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/8083:LOC102237353 ^@ http://purl.uniprot.org/uniprot/M4AFN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||Nucleus http://togogenome.org/gene/8083:nsf ^@ http://purl.uniprot.org/uniprot/M4A8Q5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. http://togogenome.org/gene/8083:LOC102230431 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1P1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:rfx1 ^@ http://purl.uniprot.org/uniprot/M4AEI9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:polg2 ^@ http://purl.uniprot.org/uniprot/M3ZVA0 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/8083:npm3 ^@ http://purl.uniprot.org/uniprot/M4AGB0 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/8083:sgms1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/8083:c6 ^@ http://purl.uniprot.org/uniprot/M4APU9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:LOC102222003 ^@ http://purl.uniprot.org/uniprot/M3ZE80 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/8083:ndufa11 ^@ http://purl.uniprot.org/uniprot/M4A0G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I NDUFA11 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102219983 ^@ http://purl.uniprot.org/uniprot/A0A3B5QF99 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. http://togogenome.org/gene/8083:lgsn ^@ http://purl.uniprot.org/uniprot/M4AIY8 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/8083:LOC102236014 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q5B9 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/8083:LOC102218909 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8K2|||http://purl.uniprot.org/uniprot/A0A3B5RF39 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Homodimer. Heterodimer; with a rar molecule.|||Nucleus|||Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. http://togogenome.org/gene/8083:c4h19orf12 ^@ http://purl.uniprot.org/uniprot/M3ZFN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the C19orf12 family.|||Mitochondrion membrane http://togogenome.org/gene/8083:LOC102219091 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHD5 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:fam96a ^@ http://purl.uniprot.org/uniprot/M3ZSC2 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/8083:LOC102225972 ^@ http://purl.uniprot.org/uniprot/M4A9U8 ^@ Similarity ^@ Belongs to the peptidase M24 family. http://togogenome.org/gene/8083:manea ^@ http://purl.uniprot.org/uniprot/M4A5I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:LOC102225572 ^@ http://purl.uniprot.org/uniprot/M4AL67 ^@ Subcellular Location Annotation ^@ Lysosome membrane|||Membrane http://togogenome.org/gene/8083:LOC102219314 ^@ http://purl.uniprot.org/uniprot/M4ACF6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102235492 ^@ http://purl.uniprot.org/uniprot/M4A8F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/8083:LOC102227981 ^@ http://purl.uniprot.org/uniprot/M3ZPL5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/8083:furin ^@ http://purl.uniprot.org/uniprot/M3ZF49 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/8083:cbr1 ^@ http://purl.uniprot.org/uniprot/M4AGN1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:dlx6 ^@ http://purl.uniprot.org/uniprot/A0A3B5QKM0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102230180 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZJ2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS19 family. http://togogenome.org/gene/8083:borcs5 ^@ http://purl.uniprot.org/uniprot/A0A3B5QSW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS5 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/8083:fgb ^@ http://purl.uniprot.org/uniprot/M4A1D1 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/8083:LOC102226677 ^@ http://purl.uniprot.org/uniprot/A0A3B5PS40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:pitx1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVR1|||http://purl.uniprot.org/uniprot/M4A1K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/8083:mrpl52 ^@ http://purl.uniprot.org/uniprot/M3ZH76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL52 family.|||Mitochondrion http://togogenome.org/gene/8083:clp1 ^@ http://purl.uniprot.org/uniprot/M4A5R1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Clp1 family. Clp1 subfamily.|||Component of the tRNA splicing endonuclease complex. Component of pre-mRNA cleavage complex II (CF-II).|||Nucleus|||Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing. http://togogenome.org/gene/8083:pten ^@ http://purl.uniprot.org/uniprot/M4AEU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4.|||Belongs to the PTEN phosphatase protein family.|||Cytoplasm|||Nucleus|||PML body|||Postsynaptic density|||dendritic spine http://togogenome.org/gene/8083:birc2 ^@ http://purl.uniprot.org/uniprot/M4A8R3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102223981 ^@ http://purl.uniprot.org/uniprot/M3ZQT0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:echs1 ^@ http://purl.uniprot.org/uniprot/M4AH17 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/8083:plpp3 ^@ http://purl.uniprot.org/uniprot/M4A9Q0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/8083:rtn4ip1 ^@ http://purl.uniprot.org/uniprot/M4AW74 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/8083:cops5 ^@ http://purl.uniprot.org/uniprot/M4A5C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN5 subfamily.|||synaptic vesicle http://togogenome.org/gene/8083:LOC102221859 ^@ http://purl.uniprot.org/uniprot/A0A3B5R0H8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:rhcg ^@ http://purl.uniprot.org/uniprot/M3ZFB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Cell membrane|||Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.|||Membrane http://togogenome.org/gene/8083:LOC102221963 ^@ http://purl.uniprot.org/uniprot/A0A3B5QL16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/8083:usp3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QX86 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/8083:LOC102229920 ^@ http://purl.uniprot.org/uniprot/M4A433 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/8083:gabrb1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q7B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:LOC102232929 ^@ http://purl.uniprot.org/uniprot/M4AJC8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme c group covalently per subunit.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102219044 ^@ http://purl.uniprot.org/uniprot/M3ZJG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/8083:LOC102223313 ^@ http://purl.uniprot.org/uniprot/M4AUU6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Nucleus|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/8083:naa35 ^@ http://purl.uniprot.org/uniprot/M4AQY5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MAK10 family.|||Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.|||Cytoplasm http://togogenome.org/gene/8083:LOC102233682 ^@ http://purl.uniprot.org/uniprot/M4A500 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/8083:cdk8 ^@ http://purl.uniprot.org/uniprot/M4A667 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:LOC102217279 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0J6 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/8083:LOC102235425 ^@ http://purl.uniprot.org/uniprot/A0A3B5QLZ5 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/8083:LOC102226920 ^@ http://purl.uniprot.org/uniprot/M3ZJ71 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/8083:LOC102222617 ^@ http://purl.uniprot.org/uniprot/M3ZEC3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:st6galnac6 ^@ http://purl.uniprot.org/uniprot/A0A3B5QV99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8083:ipmk ^@ http://purl.uniprot.org/uniprot/M4AJC7 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/8083:LOC102216546 ^@ http://purl.uniprot.org/uniprot/A0A3B5PRN4|||http://purl.uniprot.org/uniprot/A0A3B5QHK9 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/8083:LOC102228623 ^@ http://purl.uniprot.org/uniprot/M3ZK38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:LOC102232825 ^@ http://purl.uniprot.org/uniprot/M3ZT02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAM50/omp85 family.|||Mitochondrion outer membrane http://togogenome.org/gene/8083:umps ^@ http://purl.uniprot.org/uniprot/M3ZHX3 ^@ Similarity ^@ In the C-terminal section; belongs to the OMP decarboxylase family.|||In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/8083:LOC102237528 ^@ http://purl.uniprot.org/uniprot/M3ZP26 ^@ Similarity ^@ Belongs to the UQCRH/QCR6 family. http://togogenome.org/gene/8083:xk ^@ http://purl.uniprot.org/uniprot/A0A3B5PS91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/8083:kcnj8 ^@ http://purl.uniprot.org/uniprot/M4ASW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/8083:LOC102217529 ^@ http://purl.uniprot.org/uniprot/M3ZVB9 ^@ Similarity ^@ Belongs to the SHMT family. http://togogenome.org/gene/8083:nbn ^@ http://purl.uniprot.org/uniprot/M3ZXQ0 ^@ Subcellular Location Annotation ^@ Nucleus|||telomere http://togogenome.org/gene/8083:LOC102220005 ^@ http://purl.uniprot.org/uniprot/A0A3B5R9U7 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/8083:LOC102222546 ^@ http://purl.uniprot.org/uniprot/A0A3B5PP98 ^@ Similarity ^@ Belongs to the PPP1R15 family. http://togogenome.org/gene/8083:mblac1 ^@ http://purl.uniprot.org/uniprot/M4A192 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/8083:cs ^@ http://purl.uniprot.org/uniprot/A0A3B5R0K6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the citrate synthase family.|||Homodimer.|||Mitochondrion matrix http://togogenome.org/gene/8083:mlst8 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGB1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LST8 family.|||Cytoplasm|||Part of TORC1 complex. Part of the TORC2 complex.|||Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. http://togogenome.org/gene/8083:dgke ^@ http://purl.uniprot.org/uniprot/M4AU17 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/8083:stk35 ^@ http://purl.uniprot.org/uniprot/M4AEH0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:LOC102221857 ^@ http://purl.uniprot.org/uniprot/M4A186 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C48 family.|||nucleolus http://togogenome.org/gene/8083:LOC102228512 ^@ http://purl.uniprot.org/uniprot/M4AEN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM59 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:LOC102232333 ^@ http://purl.uniprot.org/uniprot/A0A3B5QE22 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102232851 ^@ http://purl.uniprot.org/uniprot/M4ALH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/8083:unc119b ^@ http://purl.uniprot.org/uniprot/A0A3B5QZE9 ^@ Similarity ^@ Belongs to the PDE6D/unc-119 family. http://togogenome.org/gene/8083:galk2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QVT1 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/8083:selenos ^@ http://purl.uniprot.org/uniprot/M3ZGU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the selenoprotein S family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102220181 ^@ http://purl.uniprot.org/uniprot/M4B0I1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102228553 ^@ http://purl.uniprot.org/uniprot/M4AHT4 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/8083:sdhc ^@ http://purl.uniprot.org/uniprot/M3ZU15 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). http://togogenome.org/gene/8083:LOC102219668 ^@ http://purl.uniprot.org/uniprot/A0A3B5QEQ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:gpd2 ^@ http://purl.uniprot.org/uniprot/M4A174 ^@ Function|||Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.|||Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device. http://togogenome.org/gene/8083:prkaca ^@ http://purl.uniprot.org/uniprot/M4AD39 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/8083:zwilch ^@ http://purl.uniprot.org/uniprot/M3ZMV1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZWILCH family.|||Component of the RZZ complex.|||Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.|||kinetochore http://togogenome.org/gene/8083:LOC102232475 ^@ http://purl.uniprot.org/uniprot/Q91988 ^@ Similarity ^@ Belongs to the NGF-beta family. http://togogenome.org/gene/8083:psap ^@ http://purl.uniprot.org/uniprot/A0A3B5RBT2 ^@ Function|||Subcellular Location Annotation ^@ Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.|||Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.|||Secreted http://togogenome.org/gene/8083:plbd2 ^@ http://purl.uniprot.org/uniprot/M3ZZL5 ^@ Function|||Similarity ^@ Belongs to the phospholipase B-like family.|||Putative phospholipase. http://togogenome.org/gene/8083:tmem201 ^@ http://purl.uniprot.org/uniprot/M4AAZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM201 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/8083:bop1 ^@ http://purl.uniprot.org/uniprot/M4ATB0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat BOP1/ERB1 family.|||Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.|||Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/8083:ncbp1 ^@ http://purl.uniprot.org/uniprot/M4AV18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NCBP1 family.|||Nucleus http://togogenome.org/gene/8083:LOC102219417 ^@ http://purl.uniprot.org/uniprot/M3ZG61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:LOC102234517 ^@ http://purl.uniprot.org/uniprot/A0A3B5PT17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:gnb1 ^@ http://purl.uniprot.org/uniprot/M4AY93 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/8083:LOC102233769 ^@ http://purl.uniprot.org/uniprot/A0A3B5QA27 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/8083:scfd1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QG03 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/8083:LOC102225407 ^@ http://purl.uniprot.org/uniprot/M4AMM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8083:LOC102221351 ^@ http://purl.uniprot.org/uniprot/M3ZMS1 ^@ Subcellular Location Annotation ^@ Cleavage furrow|||Endosome membrane|||Membrane|||Midbody|||Recycling endosome membrane http://togogenome.org/gene/8083:LOC102232016 ^@ http://purl.uniprot.org/uniprot/M4AW02 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/8083:LOC102230841 ^@ http://purl.uniprot.org/uniprot/M4AE81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.|||Membrane http://togogenome.org/gene/8083:LOC102232942 ^@ http://purl.uniprot.org/uniprot/M4A250 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/8083:LOC102231810 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q7C0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit beta family.|||Heterodimer of an alpha and a beta chain.|||Involved in gametogenesis and steroidogenesis.|||Secreted http://togogenome.org/gene/8083:tlcd1 ^@ http://purl.uniprot.org/uniprot/A0A3B5RC07 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102236028 ^@ http://purl.uniprot.org/uniprot/M4A5E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/8083:LOC102220715 ^@ http://purl.uniprot.org/uniprot/A0A3B5R8I1 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/8083:LOC102217519 ^@ http://purl.uniprot.org/uniprot/A0A3B5PYR1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102221013 ^@ http://purl.uniprot.org/uniprot/M3ZZ26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/8083:vamp7 ^@ http://purl.uniprot.org/uniprot/M4ASX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/8083:psma1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PZP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/8083:mrps10 ^@ http://purl.uniprot.org/uniprot/M3ZM00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS10 family.|||Mitochondrion http://togogenome.org/gene/8083:aldh5a1 ^@ http://purl.uniprot.org/uniprot/M4AJB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aldehyde dehydrogenase family.|||Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).|||Homotetramer.|||Mitochondrion http://togogenome.org/gene/8083:LOC102237506 ^@ http://purl.uniprot.org/uniprot/M4AHV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/8083:LOC102229206 ^@ http://purl.uniprot.org/uniprot/M4ACV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:LOC102216857 ^@ http://purl.uniprot.org/uniprot/M3ZHP9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer or homodimer. http://togogenome.org/gene/8083:LOC102221892 ^@ http://purl.uniprot.org/uniprot/M4AG08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/8083:LOC102229098 ^@ http://purl.uniprot.org/uniprot/M4ASC8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/8083:LOC102235085 ^@ http://purl.uniprot.org/uniprot/M3ZQM7 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/8083:LOC102230973 ^@ http://purl.uniprot.org/uniprot/M3ZGX9 ^@ Similarity|||Subcellular Location Annotation ^@ In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/8083:LOC102238024 ^@ http://purl.uniprot.org/uniprot/M4AX19 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat COPB2 family.|||COPI-coated vesicle membrane|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.|||This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner. http://togogenome.org/gene/8083:dpys ^@ http://purl.uniprot.org/uniprot/A0A3B5QZU1 ^@ PTM|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Carbamylation allows a single lysine to coordinate two divalent metal cations. http://togogenome.org/gene/8083:clstn1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QP21|||http://purl.uniprot.org/uniprot/M4AAU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calsyntenin family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Postsynaptic cell membrane http://togogenome.org/gene/8083:unc50 ^@ http://purl.uniprot.org/uniprot/A0A3B5QLH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-50 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/8083:LOC102227256 ^@ http://purl.uniprot.org/uniprot/M3ZKI2 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/8083:guk1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZJ4 ^@ Similarity ^@ Belongs to the guanylate kinase family. http://togogenome.org/gene/8083:kif2a ^@ http://purl.uniprot.org/uniprot/A0A3B5PPT7|||http://purl.uniprot.org/uniprot/M3ZY50 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/8083:LOC102219537 ^@ http://purl.uniprot.org/uniprot/A0A3B5PRD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Engrailed homeobox family.|||Nucleus http://togogenome.org/gene/8083:ndufb2 ^@ http://purl.uniprot.org/uniprot/M3ZR07 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102223832 ^@ http://purl.uniprot.org/uniprot/M3ZWF7 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/8083:u2af2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAJ8|||http://purl.uniprot.org/uniprot/M4AC09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the splicing factor SR family.|||Necessary for the splicing of pre-mRNA.|||Nucleus http://togogenome.org/gene/8083:LOC102229207 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q783 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase CarF family.|||Membrane http://togogenome.org/gene/8083:LOC102234216 ^@ http://purl.uniprot.org/uniprot/M4AVG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NASP family.|||Nucleus http://togogenome.org/gene/8083:nup62 ^@ http://purl.uniprot.org/uniprot/M3ZSH7 ^@ Similarity ^@ Belongs to the nucleoporin NSP1/NUP62 family. http://togogenome.org/gene/8083:LOC102221344 ^@ http://purl.uniprot.org/uniprot/A0A3B5QK94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:emc7 ^@ http://purl.uniprot.org/uniprot/M3ZZZ3 ^@ Similarity|||Subunit ^@ Belongs to the EMC7 family.|||Component of the ER membrane protein complex (EMC). http://togogenome.org/gene/8083:LOC102234361 ^@ http://purl.uniprot.org/uniprot/M3ZNL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:LOC102236691 ^@ http://purl.uniprot.org/uniprot/M4AYU7 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/8083:slc12a4 ^@ http://purl.uniprot.org/uniprot/M4A0B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/8083:aarsd1 ^@ http://purl.uniprot.org/uniprot/M4APA5 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily. http://togogenome.org/gene/8083:LOC102216635 ^@ http://purl.uniprot.org/uniprot/M4ARX6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102217699 ^@ http://purl.uniprot.org/uniprot/A0A3B5RC54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/8083:LOC102221934 ^@ http://purl.uniprot.org/uniprot/M4AHT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Cell membrane|||Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.|||Membrane http://togogenome.org/gene/8083:dhx29 ^@ http://purl.uniprot.org/uniprot/M3ZRN4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.|||Belongs to the DEAD box helicase family. DEAH subfamily.|||Cytoplasm|||Part of the 43S pre-initiation complex (PIC). http://togogenome.org/gene/8083:ehd2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QKD1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/8083:LOC102229085 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9Z1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102229735 ^@ http://purl.uniprot.org/uniprot/M4AB42 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/8083:LOC102218737 ^@ http://purl.uniprot.org/uniprot/A0A3B5R6Q4 ^@ Similarity ^@ Belongs to the peptidase S51 family. http://togogenome.org/gene/8083:ifih1 ^@ http://purl.uniprot.org/uniprot/M4AAT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/8083:LOC102236455 ^@ http://purl.uniprot.org/uniprot/M4AGF2 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/8083:agxt ^@ http://purl.uniprot.org/uniprot/M3ZNH0 ^@ Similarity|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer. http://togogenome.org/gene/8083:atg16l1 ^@ http://purl.uniprot.org/uniprot/M3ZF47 ^@ Similarity ^@ Belongs to the WD repeat ATG16 family. http://togogenome.org/gene/8083:nrm ^@ http://purl.uniprot.org/uniprot/A0A3B5QW77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nurim family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/8083:ism2 ^@ http://purl.uniprot.org/uniprot/M4A8Y6 ^@ Similarity ^@ Belongs to the isthmin family. http://togogenome.org/gene/8083:pitpnm3 ^@ http://purl.uniprot.org/uniprot/M3ZP69 ^@ Similarity ^@ Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. http://togogenome.org/gene/8083:msl3 ^@ http://purl.uniprot.org/uniprot/M4A3P2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:pea15 ^@ http://purl.uniprot.org/uniprot/M4AQ31 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:arpc2 ^@ http://purl.uniprot.org/uniprot/A0A3B5R2K2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC2 family.|||Cell projection|||Component of the Arp2/3 complex.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/8083:glyctk ^@ http://purl.uniprot.org/uniprot/A0A3B5RDF8 ^@ Similarity ^@ Belongs to the glycerate kinase type-2 family. http://togogenome.org/gene/8083:kdsr ^@ http://purl.uniprot.org/uniprot/M4APX0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:LOC102221366 ^@ http://purl.uniprot.org/uniprot/M4AV08 ^@ Similarity ^@ Belongs to the PDE6D/unc-119 family. http://togogenome.org/gene/8083:fam166b ^@ http://purl.uniprot.org/uniprot/M3ZNA9 ^@ Similarity ^@ Belongs to the CIMIP2 family. http://togogenome.org/gene/8083:LOC102233666 ^@ http://purl.uniprot.org/uniprot/M4AT54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/8083:LOC102235006 ^@ http://purl.uniprot.org/uniprot/A0A3B5QV33|||http://purl.uniprot.org/uniprot/M4ANB7 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/8083:arhgef6 ^@ http://purl.uniprot.org/uniprot/M4AG52 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/8083:LOC102229680 ^@ http://purl.uniprot.org/uniprot/M4A9M3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:ssr4 ^@ http://purl.uniprot.org/uniprot/M4A8K7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-delta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/8083:lmod1 ^@ http://purl.uniprot.org/uniprot/M3ZUY0 ^@ Subcellular Location Annotation ^@ cytoskeleton|||sarcomere http://togogenome.org/gene/8083:LOC102238377 ^@ http://purl.uniprot.org/uniprot/M4A6U1 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/8083:selenoo ^@ http://purl.uniprot.org/uniprot/M4AXP2 ^@ Similarity ^@ Belongs to the SELO family. http://togogenome.org/gene/8083:LOC102224404 ^@ http://purl.uniprot.org/uniprot/M3ZP37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Golgi pH regulator (TC 1.A.38) family.|||Membrane http://togogenome.org/gene/8083:LOC102216706 ^@ http://purl.uniprot.org/uniprot/M4AQG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the argonaute family. Ago subfamily.|||P-body|||Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. http://togogenome.org/gene/8083:dyrk1a ^@ http://purl.uniprot.org/uniprot/M3ZHM0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/8083:ntn4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QES4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:tex261 ^@ http://purl.uniprot.org/uniprot/M3ZI12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVP26 family.|||Membrane http://togogenome.org/gene/8083:poll ^@ http://purl.uniprot.org/uniprot/M3ZCZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Nucleus http://togogenome.org/gene/8083:gatm ^@ http://purl.uniprot.org/uniprot/M3ZIR6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the amidinotransferase family.|||Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development.|||Homodimer.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102237865 ^@ http://purl.uniprot.org/uniprot/M4AFP1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102228038 ^@ http://purl.uniprot.org/uniprot/M3ZQP6 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/8083:LOC102235623 ^@ http://purl.uniprot.org/uniprot/M4AAH6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hcp beta-lactamase family.|||Mitochondrion intermembrane space|||Required for assembly of mitochondrial respiratory chain complexes. http://togogenome.org/gene/8083:LOC102224028 ^@ http://purl.uniprot.org/uniprot/M3ZML5 ^@ Similarity ^@ Belongs to the PROTOR family. http://togogenome.org/gene/8083:LOC102217366 ^@ http://purl.uniprot.org/uniprot/M4AS12 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).|||Membrane|||Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. http://togogenome.org/gene/8083:LOC102236517 ^@ http://purl.uniprot.org/uniprot/M4B030 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Binds with high affinity to CRF receptors 2-alpha and 2-beta.|||Secreted|||Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. http://togogenome.org/gene/8083:LOC102226141 ^@ http://purl.uniprot.org/uniprot/M3ZF69 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/8083:aldh8a1 ^@ http://purl.uniprot.org/uniprot/M3ZQ70 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/8083:tma16 ^@ http://purl.uniprot.org/uniprot/M4A0S5 ^@ Function|||Similarity|||Subunit ^@ Associates with pre-60S ribosomal particles.|||Belongs to the TMA16 family.|||Involved in the biogenesis of the 60S ribosomal subunit in the nucleus. http://togogenome.org/gene/8083:vps29 ^@ http://purl.uniprot.org/uniprot/A0A3B5RA41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.|||Belongs to the VPS29 family.|||Endosome membrane http://togogenome.org/gene/8083:LOC102217437 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calreticulin family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/8083:LOC102238072 ^@ http://purl.uniprot.org/uniprot/A0A3B5QH47 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/8083:LOC102236151 ^@ http://purl.uniprot.org/uniprot/M3ZLL7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:c7h2orf40 ^@ http://purl.uniprot.org/uniprot/M4AAY7 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the augurin family.|||Cytoplasm|||Membrane|||Secreted http://togogenome.org/gene/8083:mrpl24 ^@ http://purl.uniprot.org/uniprot/M4AKY6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/8083:LOC102218804 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3V6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102217449 ^@ http://purl.uniprot.org/uniprot/M4B0R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/8083:nagpa ^@ http://purl.uniprot.org/uniprot/M4AGK7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:stx10 ^@ http://purl.uniprot.org/uniprot/M4AH99 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane http://togogenome.org/gene/8083:ppp1r2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QT39 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 2 family. http://togogenome.org/gene/8083:LOC102226217 ^@ http://purl.uniprot.org/uniprot/M3ZMN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRB/QCR7 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:tbrg1 ^@ http://purl.uniprot.org/uniprot/M3ZH57 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102234910 ^@ http://purl.uniprot.org/uniprot/A0A3B5RFI8 ^@ Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family. http://togogenome.org/gene/8083:pole2 ^@ http://purl.uniprot.org/uniprot/M4A173 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase epsilon subunit B family.|||Nucleus|||Participates in DNA repair and in chromosomal DNA replication. http://togogenome.org/gene/8083:cnr1 ^@ http://purl.uniprot.org/uniprot/M4AYY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for cannabinoids. Mediates many cannabinoid-induced effects in the central nervous system (CNS), as well as in peripheral tissues. Signaling typically involves reduction in cyclic AMP.|||Membrane|||Mitochondrion outer membrane|||Presynapse|||Synapse|||axon http://togogenome.org/gene/8083:LOC102217378 ^@ http://purl.uniprot.org/uniprot/M4ACJ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ATPase alpha/beta chains family.|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits. http://togogenome.org/gene/8083:LOC102236994 ^@ http://purl.uniprot.org/uniprot/A0A3B5QE50|||http://purl.uniprot.org/uniprot/A0A3B5R784 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102237105 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q4M9 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||RNA-binding protein that regulates alternative splicing events. http://togogenome.org/gene/8083:march4 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q5R9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:gjd2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZX4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8083:pdss1 ^@ http://purl.uniprot.org/uniprot/M4A1K2 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/8083:ebf3 ^@ http://purl.uniprot.org/uniprot/M4AE70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/8083:ndfip1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q2T7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:marveld3 ^@ http://purl.uniprot.org/uniprot/M4A0H5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:rpn2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWG6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SWP1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/8083:tspan33 ^@ http://purl.uniprot.org/uniprot/A0A3B5PR14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:LOC102220007 ^@ http://purl.uniprot.org/uniprot/M3ZKZ1 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/8083:LOC102223288 ^@ http://purl.uniprot.org/uniprot/M3ZP36 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.|||extracellular matrix http://togogenome.org/gene/8083:LOC102226174 ^@ http://purl.uniprot.org/uniprot/M4ASF1 ^@ Similarity ^@ Belongs to the FAM122 family. http://togogenome.org/gene/8083:bcl2l1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PQJ0 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/8083:tspan8 ^@ http://purl.uniprot.org/uniprot/M3ZWJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:LOC102230208 ^@ http://purl.uniprot.org/uniprot/M4A9F5 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/8083:rad51d ^@ http://purl.uniprot.org/uniprot/M4AAL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Nucleus http://togogenome.org/gene/8083:foxo4 ^@ http://purl.uniprot.org/uniprot/M4AFA7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:nlgn4x ^@ http://purl.uniprot.org/uniprot/M4AWY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:nos1 ^@ http://purl.uniprot.org/uniprot/M3ZK07 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOS family.|||Binds 1 FAD.|||Binds 1 FMN.|||Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.|||dendritic spine|||sarcolemma http://togogenome.org/gene/8083:LOC102229995 ^@ http://purl.uniprot.org/uniprot/M4AWY9 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:LOC102222359 ^@ http://purl.uniprot.org/uniprot/M4A381 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC3 family.|||Component of the ER membrane protein complex (EMC).|||Membrane http://togogenome.org/gene/8083:trove2 ^@ http://purl.uniprot.org/uniprot/M3ZRK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ro 60 kDa family.|||Cytoplasm http://togogenome.org/gene/8083:gins3 ^@ http://purl.uniprot.org/uniprot/M4AN20 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS3/PSF3 family.|||Chromosome|||Component of the GINS complex.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication. http://togogenome.org/gene/8083:LOC102220933 ^@ http://purl.uniprot.org/uniprot/M4AV01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Musashi family.|||Cytoplasm http://togogenome.org/gene/8083:p4ha1 ^@ http://purl.uniprot.org/uniprot/M3ZNX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/8083:LOC102226614 ^@ http://purl.uniprot.org/uniprot/A0A3B5PNC5 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:LOC102223454 ^@ http://purl.uniprot.org/uniprot/M4AD72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/8083:LOC102227490 ^@ http://purl.uniprot.org/uniprot/M3ZTV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:LOC102222293 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1G3 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:LOC102216645 ^@ http://purl.uniprot.org/uniprot/M4A566 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102224910 ^@ http://purl.uniprot.org/uniprot/M4ARD1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102234776 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102235369 ^@ http://purl.uniprot.org/uniprot/M3ZY47 ^@ Similarity ^@ In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.|||In the N-terminal section; belongs to the glutamate 5-kinase family. http://togogenome.org/gene/8083:llph ^@ http://purl.uniprot.org/uniprot/M3ZQP4 ^@ Similarity ^@ Belongs to the learning-associated protein family. http://togogenome.org/gene/8083:LOC102233598 ^@ http://purl.uniprot.org/uniprot/A0A3B5QDY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/8083:ints3 ^@ http://purl.uniprot.org/uniprot/M4ASS8 ^@ Similarity ^@ Belongs to the Integrator subunit 3 family. http://togogenome.org/gene/8083:ppm1a ^@ http://purl.uniprot.org/uniprot/M4AGC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/8083:LOC102224326 ^@ http://purl.uniprot.org/uniprot/M4AIM9 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/8083:LOC102231308 ^@ http://purl.uniprot.org/uniprot/A0A3B5RE59 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102231102 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8K5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.|||Membrane http://togogenome.org/gene/8083:hpse2 ^@ http://purl.uniprot.org/uniprot/M3ZK22 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/8083:LOC102225057 ^@ http://purl.uniprot.org/uniprot/M3ZFG9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8083:med29 ^@ http://purl.uniprot.org/uniprot/M3ZNU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 29 family.|||Nucleus http://togogenome.org/gene/8083:prpf38b ^@ http://purl.uniprot.org/uniprot/A0A3B5QVR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||May be required for pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/8083:LOC102219474 ^@ http://purl.uniprot.org/uniprot/M4AJK7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102222388 ^@ http://purl.uniprot.org/uniprot/M4AIH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/8083:LOC102232744 ^@ http://purl.uniprot.org/uniprot/M4AJP9 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/8083:LOC102237570 ^@ http://purl.uniprot.org/uniprot/M4ATJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Membrane|||Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity. http://togogenome.org/gene/8083:mpeg1 ^@ http://purl.uniprot.org/uniprot/M4ALS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MPEG1 family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/8083:LOC102227185 ^@ http://purl.uniprot.org/uniprot/M4AQA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNTX/VTX toxin family.|||Secreted http://togogenome.org/gene/8083:LOC102233911 ^@ http://purl.uniprot.org/uniprot/A0A3B5REK3 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:LOC102227184 ^@ http://purl.uniprot.org/uniprot/M4A1X9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/8083:inpp5a ^@ http://purl.uniprot.org/uniprot/A0A3B5PTE1 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family. http://togogenome.org/gene/8083:prkce ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/8083:LOC102229902 ^@ http://purl.uniprot.org/uniprot/A0A3B5QS36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/8083:LOC102232671 ^@ http://purl.uniprot.org/uniprot/M4AIW6 ^@ Similarity ^@ Belongs to the G-alpha family. G(s) subfamily. http://togogenome.org/gene/8083:LOC102228102 ^@ http://purl.uniprot.org/uniprot/M4AMD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/8083:LOC102234795 ^@ http://purl.uniprot.org/uniprot/M3ZDX6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102227844 ^@ http://purl.uniprot.org/uniprot/M4A436 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:LOC102225971 ^@ http://purl.uniprot.org/uniprot/M3ZK79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 26 family.|||Nucleus http://togogenome.org/gene/8083:tsg101 ^@ http://purl.uniprot.org/uniprot/M4AL45 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily. http://togogenome.org/gene/8083:mrpl43 ^@ http://purl.uniprot.org/uniprot/M4AT86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL43 family.|||Mitochondrion http://togogenome.org/gene/8083:LOC102220864 ^@ http://purl.uniprot.org/uniprot/M4A423 ^@ Function|||Similarity ^@ Belongs to the E(R) family.|||May have a role in the cell cycle. http://togogenome.org/gene/8083:LOC102229030 ^@ http://purl.uniprot.org/uniprot/M3ZNU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Cell membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102221627 ^@ http://purl.uniprot.org/uniprot/M4A451 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRQ/QCR8 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:mrap2 ^@ http://purl.uniprot.org/uniprot/A0A3B5R8G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:lrrn3 ^@ http://purl.uniprot.org/uniprot/M4AYN9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:ints11 ^@ http://purl.uniprot.org/uniprot/M4ADE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.|||Nucleus http://togogenome.org/gene/8083:ngrn ^@ http://purl.uniprot.org/uniprot/A0A3B5RDR0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neugrin family.|||Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.|||Mitochondrion membrane|||Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system. http://togogenome.org/gene/8083:LOC102226547 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7P3|||http://purl.uniprot.org/uniprot/A0A3B5R8H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/8083:epha5 ^@ http://purl.uniprot.org/uniprot/A0A3B5R9W6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:tmem258 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDJ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST5 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/8083:LOC102229947 ^@ http://purl.uniprot.org/uniprot/M3ZTS6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:isca2 ^@ http://purl.uniprot.org/uniprot/M4AKI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/8083:eif5a ^@ http://purl.uniprot.org/uniprot/M4AMV6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||Membrane|||Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group. http://togogenome.org/gene/8083:plxna2 ^@ http://purl.uniprot.org/uniprot/M4ACX6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102234606 ^@ http://purl.uniprot.org/uniprot/A0A3B5PYW8 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/8083:LOC106699834 ^@ http://purl.uniprot.org/uniprot/M4AD90 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:LOC102233275 ^@ http://purl.uniprot.org/uniprot/M4AH50 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/8083:LOC102226042 ^@ http://purl.uniprot.org/uniprot/A0A3B5QCL7|||http://purl.uniprot.org/uniprot/M4AQS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/8083:LOC102235277 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1G4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||dendrite http://togogenome.org/gene/8083:LOC102216735 ^@ http://purl.uniprot.org/uniprot/A0A3B5PNH2|||http://purl.uniprot.org/uniprot/A0A3B5RCW9|||http://purl.uniprot.org/uniprot/M3ZWA5 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homo- and heterotetramers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102238379 ^@ http://purl.uniprot.org/uniprot/A0A3B5QRP5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:chsy1 ^@ http://purl.uniprot.org/uniprot/M3ZGT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/8083:jpt2 ^@ http://purl.uniprot.org/uniprot/M4ABR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:fgf10 ^@ http://purl.uniprot.org/uniprot/M4A6R2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:prkca ^@ http://purl.uniprot.org/uniprot/M3ZWP5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.|||Cytoplasm|||Membrane http://togogenome.org/gene/8083:tmem41b ^@ http://purl.uniprot.org/uniprot/M4A4S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/8083:bglap ^@ http://purl.uniprot.org/uniprot/A0A3B5QQD9 ^@ Function|||Similarity ^@ Belongs to the osteocalcin/matrix Gla protein family.|||The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein (By similarity). The carboxylated form binds strongly to apatite and calcium. http://togogenome.org/gene/8083:znf326 ^@ http://purl.uniprot.org/uniprot/A0A3B5QCG6 ^@ Similarity ^@ Belongs to the AKAP95 family. http://togogenome.org/gene/8083:tomm5 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom5 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/8083:kcne4 ^@ http://purl.uniprot.org/uniprot/M4A1E1 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/8083:mgst1 ^@ http://purl.uniprot.org/uniprot/M4AMQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/8083:grm5 ^@ http://purl.uniprot.org/uniprot/A0A3B5QD15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102233053 ^@ http://purl.uniprot.org/uniprot/M3ZUD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102225200 ^@ http://purl.uniprot.org/uniprot/M4AKR3 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/8083:cul2 ^@ http://purl.uniprot.org/uniprot/M4A159 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/8083:cog6 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3E7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COG6 family.|||Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.|||Golgi apparatus membrane|||Membrane|||Required for normal Golgi function. http://togogenome.org/gene/8083:jpt1 ^@ http://purl.uniprot.org/uniprot/M4AJC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102222360 ^@ http://purl.uniprot.org/uniprot/M3ZNP5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||synaptic vesicle membrane http://togogenome.org/gene/8083:mgst2 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1J5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102230709 ^@ http://purl.uniprot.org/uniprot/A0A3B5REJ0 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/8083:tcp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDY0 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/8083:LOC102216956 ^@ http://purl.uniprot.org/uniprot/M3ZZC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/8083:LOC102236126 ^@ http://purl.uniprot.org/uniprot/A0A3B5R9A0 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/8083:LOC102226505 ^@ http://purl.uniprot.org/uniprot/M3ZE28 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-12B family.|||Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.|||Secreted http://togogenome.org/gene/8083:lhcgr ^@ http://purl.uniprot.org/uniprot/M4A910 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||Membrane|||Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. http://togogenome.org/gene/8083:dgat1 ^@ http://purl.uniprot.org/uniprot/M4ALS7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Homodimer or homotetramer; both forms have similar enzymatic activities.|||Membrane http://togogenome.org/gene/8083:man1b1 ^@ http://purl.uniprot.org/uniprot/M3ZPT7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/8083:nop2 ^@ http://purl.uniprot.org/uniprot/M4AAN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||nucleolus http://togogenome.org/gene/8083:LOC102229853 ^@ http://purl.uniprot.org/uniprot/M4A7M7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. http://togogenome.org/gene/8083:LOC102221180 ^@ http://purl.uniprot.org/uniprot/A0A3B5QE33 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:sgf29 ^@ http://purl.uniprot.org/uniprot/M4A915 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:map4k3 ^@ http://purl.uniprot.org/uniprot/A0A3B5PT99 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. http://togogenome.org/gene/8083:ube2b ^@ http://purl.uniprot.org/uniprot/A0A3B5Q2L3 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:sprn ^@ http://purl.uniprot.org/uniprot/M4AZC5 ^@ Similarity ^@ Belongs to the SPRN family. http://togogenome.org/gene/8083:LOC102230337 ^@ http://purl.uniprot.org/uniprot/A0A3B5R6M3 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/8083:LOC102228332 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||cytoskeleton http://togogenome.org/gene/8083:LOC102237188 ^@ http://purl.uniprot.org/uniprot/M4ADS9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102220931 ^@ http://purl.uniprot.org/uniprot/A0A3B5QCG2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMDT1/EMRE family.|||Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.|||Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102218096 ^@ http://purl.uniprot.org/uniprot/M4ALV2 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/8083:armc1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAX7 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/8083:camk2n2 ^@ http://purl.uniprot.org/uniprot/M4AKS4 ^@ Similarity ^@ Belongs to the CAMK2N family. http://togogenome.org/gene/8083:LOC102236183 ^@ http://purl.uniprot.org/uniprot/M4AJ22 ^@ Similarity ^@ Belongs to the histidine acid phosphatase family. MINPP1 subfamily. http://togogenome.org/gene/8083:LOC102223570 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/8083:igf2bp2 ^@ http://purl.uniprot.org/uniprot/M4AM60 ^@ Similarity ^@ Belongs to the RRM IMP/VICKZ family. http://togogenome.org/gene/8083:asic2 ^@ http://purl.uniprot.org/uniprot/M4A1F9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102231261 ^@ http://purl.uniprot.org/uniprot/M4AM39 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8083:rab3a ^@ http://purl.uniprot.org/uniprot/A0A3B5QEA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/8083:LOC102233119 ^@ http://purl.uniprot.org/uniprot/M4ADK9 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:krtcap2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KRTCAP2 family.|||Membrane http://togogenome.org/gene/8083:LOC102222534 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q165 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/8083:mapk1 ^@ http://purl.uniprot.org/uniprot/M3ZW74 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/8083:tcf25 ^@ http://purl.uniprot.org/uniprot/M3ZLD8 ^@ Similarity ^@ Belongs to the TCF25 family. http://togogenome.org/gene/8083:LOC102236919 ^@ http://purl.uniprot.org/uniprot/M3ZIJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Early endosome|||Endosome|||Involved in trafficking and recycling of synaptic vesicles.|||Late endosome|||Membrane|||Recycling endosome|||autophagosome|||synaptic vesicle|||trans-Golgi network http://togogenome.org/gene/8083:LOC102218628 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8083:ccdc90b ^@ http://purl.uniprot.org/uniprot/M3ZXH1 ^@ Similarity ^@ Belongs to the CCDC90 family. http://togogenome.org/gene/8083:rnf121 ^@ http://purl.uniprot.org/uniprot/M4A7J1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102223706 ^@ http://purl.uniprot.org/uniprot/A0A3B5QJF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/8083:adgra3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QTB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/8083:ift57 ^@ http://purl.uniprot.org/uniprot/M3ZD63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT57 family.|||cilium basal body http://togogenome.org/gene/8083:hspb7 ^@ http://purl.uniprot.org/uniprot/M4AD54 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/8083:LOC102230261 ^@ http://purl.uniprot.org/uniprot/M3ZWI6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:cept1 ^@ http://purl.uniprot.org/uniprot/M3ZUX6 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/8083:LOC102220535 ^@ http://purl.uniprot.org/uniprot/M4AJ92 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 6 family.|||Binds 1 Mn(2+) ion per subunit.|||Membrane http://togogenome.org/gene/8083:fopnl ^@ http://purl.uniprot.org/uniprot/M3ZRU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP43 family.|||cilium basal body http://togogenome.org/gene/8083:mtrf1l ^@ http://purl.uniprot.org/uniprot/M4ARV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/8083:cdc37 ^@ http://purl.uniprot.org/uniprot/M3ZDF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102219986 ^@ http://purl.uniprot.org/uniprot/M4B052 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:rpl37 ^@ http://purl.uniprot.org/uniprot/M3ZSF7 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/8083:LOC102218266 ^@ http://purl.uniprot.org/uniprot/M4A855 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/8083:barhl2 ^@ http://purl.uniprot.org/uniprot/A0A3B5R453 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102228878 ^@ http://purl.uniprot.org/uniprot/M3ZGC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Membrane http://togogenome.org/gene/8083:alad ^@ http://purl.uniprot.org/uniprot/M4A2I7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ALAD family.|||Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.|||Homooctamer; active form. Homohexamer; low activity form. http://togogenome.org/gene/8083:LOC102230139 ^@ http://purl.uniprot.org/uniprot/A0A3B5QSP4 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/8083:LOC102217700 ^@ http://purl.uniprot.org/uniprot/M4AQC9 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:LOC102237500 ^@ http://purl.uniprot.org/uniprot/M4AEY0 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/8083:anapc11 ^@ http://purl.uniprot.org/uniprot/M4AUA5 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/8083:LOC102226178 ^@ http://purl.uniprot.org/uniprot/A0A3B5R9J1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:lcor ^@ http://purl.uniprot.org/uniprot/A0A3B5R864 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:cldn20 ^@ http://purl.uniprot.org/uniprot/M4AZZ3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/8083:snrnp27 ^@ http://purl.uniprot.org/uniprot/A0A3B5REG4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNUT3 family.|||May play a role in mRNA splicing.|||Nucleus|||Part of a tri-snRNP complex. http://togogenome.org/gene/8083:LOC102219427 ^@ http://purl.uniprot.org/uniprot/M4AMX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/8083:mau2 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q221 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCC4/mau-2 family.|||nucleoplasm http://togogenome.org/gene/8083:LOC102220224 ^@ http://purl.uniprot.org/uniprot/A0A3B5QUC4 ^@ Similarity ^@ Belongs to the FAM131 family. http://togogenome.org/gene/8083:LOC102228233 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1H4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8083:prodh2 ^@ http://purl.uniprot.org/uniprot/M4AH87 ^@ Function|||Similarity ^@ Belongs to the proline oxidase family.|||Converts proline to delta-1-pyrroline-5-carboxylate. http://togogenome.org/gene/8083:tarbp2 ^@ http://purl.uniprot.org/uniprot/M4ATS5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TARBP2 family.|||Cytoplasm|||Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.|||Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. http://togogenome.org/gene/8083:LOC102236494 ^@ http://purl.uniprot.org/uniprot/M4ACR8 ^@ Similarity ^@ Belongs to the CBP3 family. http://togogenome.org/gene/8083:LOC102224937 ^@ http://purl.uniprot.org/uniprot/M4AXW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane http://togogenome.org/gene/8083:slc25a10 ^@ http://purl.uniprot.org/uniprot/M4ADR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:LOC102223278 ^@ http://purl.uniprot.org/uniprot/A0A3B5PNN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spire family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/8083:nprl2 ^@ http://purl.uniprot.org/uniprot/M4AR75 ^@ Similarity ^@ Belongs to the NPR2 family. http://togogenome.org/gene/8083:LOC102232594 ^@ http://purl.uniprot.org/uniprot/M4ADF5 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:LOC102226246 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/8083:emc3 ^@ http://purl.uniprot.org/uniprot/M3ZHH1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC3 family.|||Component of the ER membrane protein complex (EMC).|||Membrane http://togogenome.org/gene/8083:fermt2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PSQ8 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/8083:yars2 ^@ http://purl.uniprot.org/uniprot/M4A5C8 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/8083:LOC102227196 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQW3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:midn ^@ http://purl.uniprot.org/uniprot/M4AD96 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:melk ^@ http://purl.uniprot.org/uniprot/M4AE03 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/8083:cacnb1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QXF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||Membrane|||sarcolemma http://togogenome.org/gene/8083:cops9 ^@ http://purl.uniprot.org/uniprot/M4A1Y2 ^@ Similarity ^@ Belongs to the CSN9 family. http://togogenome.org/gene/8083:rbm42 ^@ http://purl.uniprot.org/uniprot/M4AEF3 ^@ Similarity ^@ Belongs to the RRM RBM42 family. http://togogenome.org/gene/8083:c5h19orf53 ^@ http://purl.uniprot.org/uniprot/A0A3B5R5V1 ^@ Similarity ^@ Belongs to the UPF0390 family. http://togogenome.org/gene/8083:tacr3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QR64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102228111 ^@ http://purl.uniprot.org/uniprot/M4A380 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:tmem151b ^@ http://purl.uniprot.org/uniprot/A0A3B5QCD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM151 family.|||Membrane http://togogenome.org/gene/8083:thnsl1 ^@ http://purl.uniprot.org/uniprot/M4A1V2 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/8083:LOC102226462 ^@ http://purl.uniprot.org/uniprot/M4AN79 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102231567 ^@ http://purl.uniprot.org/uniprot/A0A3B5PS98 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/8083:ppm1l ^@ http://purl.uniprot.org/uniprot/A0A3B5PWY1|||http://purl.uniprot.org/uniprot/A0A3B5PZL8 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/8083:LOC102225977 ^@ http://purl.uniprot.org/uniprot/M3ZQW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Membrane http://togogenome.org/gene/8083:LOC102218305 ^@ http://purl.uniprot.org/uniprot/M4ASU7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:plin2 ^@ http://purl.uniprot.org/uniprot/M4A219 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/8083:pex5 ^@ http://purl.uniprot.org/uniprot/A0A3B5QM52|||http://purl.uniprot.org/uniprot/M4A9N2 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/8083:mmab ^@ http://purl.uniprot.org/uniprot/M4A0M7 ^@ Similarity ^@ Belongs to the Cob(I)alamin adenosyltransferase family. http://togogenome.org/gene/8083:marveld2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PPL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/8083:LOC102230969 ^@ http://purl.uniprot.org/uniprot/M3ZX97 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP2 family.|||Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.|||Membrane http://togogenome.org/gene/8083:LOC102226955 ^@ http://purl.uniprot.org/uniprot/M3ZPR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:LOC102231225 ^@ http://purl.uniprot.org/uniprot/M4AJM3 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/8083:LOC102237373 ^@ http://purl.uniprot.org/uniprot/A0A3B5RD61 ^@ Similarity ^@ Belongs to the CAS family. http://togogenome.org/gene/8083:LOC102220687 ^@ http://purl.uniprot.org/uniprot/M4AWZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/8083:LOC102228823 ^@ http://purl.uniprot.org/uniprot/A0A3B5R243 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:tyrp1 ^@ http://purl.uniprot.org/uniprot/M3ZRT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/8083:brinp1 ^@ http://purl.uniprot.org/uniprot/M4AA13 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/8083:LOC102226186 ^@ http://purl.uniprot.org/uniprot/A0A3B5R1C6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/8083:LOC102233648 ^@ http://purl.uniprot.org/uniprot/A0A3B5RF50 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:alpl ^@ http://purl.uniprot.org/uniprot/M4ATC3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alkaline phosphatase family.|||Binds 1 Mg(2+) ion.|||Binds 2 Zn(2+) ions.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/8083:LOC102236137 ^@ http://purl.uniprot.org/uniprot/M4B0Y7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:e2f8 ^@ http://purl.uniprot.org/uniprot/M4A714 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/8083:cplx2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/8083:rpl22l1 ^@ http://purl.uniprot.org/uniprot/M4AC77 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/8083:pard6g ^@ http://purl.uniprot.org/uniprot/M3ZN64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/8083:LOC102223244 ^@ http://purl.uniprot.org/uniprot/M4ARI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:mapk6 ^@ http://purl.uniprot.org/uniprot/M3ZIW5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/8083:zdhhc17 ^@ http://purl.uniprot.org/uniprot/M3ZVR6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Cytoplasmic vesicle membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/8083:LOC102225513 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1N5 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/8083:ildr2 ^@ http://purl.uniprot.org/uniprot/M4ABE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. LISCH7 family.|||Membrane|||tight junction http://togogenome.org/gene/8083:LOC102225656 ^@ http://purl.uniprot.org/uniprot/M4APU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:stmn4 ^@ http://purl.uniprot.org/uniprot/M3ZZY5 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/8083:LOC102236647 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q5E9 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/8083:stk3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QE87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Nucleus http://togogenome.org/gene/8083:LOC102227949 ^@ http://purl.uniprot.org/uniprot/M4AW23 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/8083:LOC102234185 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZZ7 ^@ Similarity ^@ Belongs to the villin/gelsolin family. http://togogenome.org/gene/8083:sod2 ^@ http://purl.uniprot.org/uniprot/M3ZM95 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems.|||Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.|||Homotetramer.|||Mitochondrion matrix http://togogenome.org/gene/8083:ssh2 ^@ http://purl.uniprot.org/uniprot/M4ACC8 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/8083:dusp6 ^@ http://purl.uniprot.org/uniprot/M3ZS09 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/8083:kif26b ^@ http://purl.uniprot.org/uniprot/M4ATE7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/8083:lrwd1 ^@ http://purl.uniprot.org/uniprot/M4A2W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRWD1 family.|||centrosome|||kinetochore|||telomere http://togogenome.org/gene/8083:sigmar1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QJ61 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ERG2 family.|||Cytoplasmic vesicle|||Endoplasmic reticulum membrane|||Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.|||Homotrimer.|||Membrane|||Nucleus envelope|||Nucleus inner membrane|||Nucleus outer membrane|||The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.|||Vesicle http://togogenome.org/gene/8083:plrg1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QCV9 ^@ Similarity ^@ Belongs to the WD repeat PRL1/PRL2 family. http://togogenome.org/gene/8083:LOC102230211 ^@ http://purl.uniprot.org/uniprot/M3ZQ89 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/8083:LOC102227900 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102220913 ^@ http://purl.uniprot.org/uniprot/M4AFK5 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.|||Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. http://togogenome.org/gene/8083:pigl ^@ http://purl.uniprot.org/uniprot/M3ZT83 ^@ Function|||Similarity ^@ Belongs to the PIGL family.|||Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol. http://togogenome.org/gene/8083:LOC102235960 ^@ http://purl.uniprot.org/uniprot/M4AFI5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:pdcd10 ^@ http://purl.uniprot.org/uniprot/M4A6Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDCD10 family.|||Cell membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:LOC102219328 ^@ http://purl.uniprot.org/uniprot/M3ZRR1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:fgf4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QUT7 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:dact3 ^@ http://purl.uniprot.org/uniprot/M3ZFK2 ^@ Similarity ^@ Belongs to the dapper family. http://togogenome.org/gene/8083:LOC102236720 ^@ http://purl.uniprot.org/uniprot/M4AFK8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:tbx4 ^@ http://purl.uniprot.org/uniprot/A0A3B5R1U4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/8083:LOC102220589 ^@ http://purl.uniprot.org/uniprot/A0A3B5R5V9 ^@ Similarity ^@ Belongs to the ependymin family. http://togogenome.org/gene/8083:kcnc1 ^@ http://purl.uniprot.org/uniprot/M3ZY10 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:zdhhc24 ^@ http://purl.uniprot.org/uniprot/A0A3B5REN3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/8083:LOC102227108 ^@ http://purl.uniprot.org/uniprot/A0A3B5QYT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LEAP2 family.|||Has an antimicrobial activity.|||Secreted http://togogenome.org/gene/8083:penk ^@ http://purl.uniprot.org/uniprot/M3ZFM3 ^@ Similarity ^@ Belongs to the opioid neuropeptide precursor family. http://togogenome.org/gene/8083:mvd ^@ http://purl.uniprot.org/uniprot/M3ZLC5 ^@ Function|||Similarity ^@ Belongs to the diphosphomevalonate decarboxylase family.|||Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. http://togogenome.org/gene/8083:eri1 ^@ http://purl.uniprot.org/uniprot/M4A3B6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:LOC102219669 ^@ http://purl.uniprot.org/uniprot/M4A5G3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:ppm1k ^@ http://purl.uniprot.org/uniprot/M4A660 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/8083:gpr135 ^@ http://purl.uniprot.org/uniprot/M4AH29 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:LOC102225363 ^@ http://purl.uniprot.org/uniprot/A0A3B5QB65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/8083:ufm1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQ31 ^@ Function|||Similarity ^@ Belongs to the UFM1 family.|||Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. http://togogenome.org/gene/8083:lamp2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PTR6|||http://purl.uniprot.org/uniprot/A0A3B5PVU2|||http://purl.uniprot.org/uniprot/A0A3B5QXW6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/8083:ube2d2 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q729 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:LOC102225583 ^@ http://purl.uniprot.org/uniprot/A0A3B5PRI9 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:LOC102227080 ^@ http://purl.uniprot.org/uniprot/M4A2P7 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/8083:dtx1 ^@ http://purl.uniprot.org/uniprot/M4AL01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/8083:aig1 ^@ http://purl.uniprot.org/uniprot/M4ATQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane http://togogenome.org/gene/8083:LOC102235587 ^@ http://purl.uniprot.org/uniprot/M4AHJ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102226157 ^@ http://purl.uniprot.org/uniprot/M3ZEF9 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/8083:LOC102225521 ^@ http://purl.uniprot.org/uniprot/M4AW08 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/8083:cct5 ^@ http://purl.uniprot.org/uniprot/M4AXN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/8083:hmgcl ^@ http://purl.uniprot.org/uniprot/M4AX94 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HMG-CoA lyase family.|||Homodimer; disulfide-linked. Can also form homotetramers.|||Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. http://togogenome.org/gene/8083:alg6 ^@ http://purl.uniprot.org/uniprot/M3ZIX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:mrps17 ^@ http://purl.uniprot.org/uniprot/M3ZYU2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/8083:LOC102227342 ^@ http://purl.uniprot.org/uniprot/M4A969 ^@ Similarity ^@ Belongs to the FAM124 family. http://togogenome.org/gene/8083:pbx3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QXC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/8083:pigv ^@ http://purl.uniprot.org/uniprot/M4A8D6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGV family.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.|||Membrane http://togogenome.org/gene/8083:camsap2 ^@ http://purl.uniprot.org/uniprot/M3ZV26 ^@ Domain|||Similarity ^@ Belongs to the CAMSAP1 family.|||The CKK domain binds microtubules. http://togogenome.org/gene/8083:abi1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1K6|||http://purl.uniprot.org/uniprot/A0A3B5QP37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/8083:appl2 ^@ http://purl.uniprot.org/uniprot/M4ASS4 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Membrane|||Nucleus|||phagosome|||ruffle http://togogenome.org/gene/8083:crabp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q4T8 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8083:LOC102236291 ^@ http://purl.uniprot.org/uniprot/M3ZFC1 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/8083:LOC102216589 ^@ http://purl.uniprot.org/uniprot/M3ZIS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/8083:dnajc24 ^@ http://purl.uniprot.org/uniprot/A0A3B5QEV9 ^@ Similarity ^@ Belongs to the DPH4 family. http://togogenome.org/gene/8083:nle1 ^@ http://purl.uniprot.org/uniprot/M4A8B1 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/8083:hbp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PS42 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. http://togogenome.org/gene/8083:LOC102237237 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q2V8|||http://purl.uniprot.org/uniprot/M4A305 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/8083:LOC102229810 ^@ http://purl.uniprot.org/uniprot/M3ZHZ6 ^@ Function ^@ Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. http://togogenome.org/gene/8083:LOC102229300 ^@ http://purl.uniprot.org/uniprot/M4AR59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/8083:nox1 ^@ http://purl.uniprot.org/uniprot/M4AGE9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102229638 ^@ http://purl.uniprot.org/uniprot/M4A6J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/8083:LOC102235727 ^@ http://purl.uniprot.org/uniprot/M3ZMK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:nkain1 ^@ http://purl.uniprot.org/uniprot/M3ZL80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102223352 ^@ http://purl.uniprot.org/uniprot/M3ZT91 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/8083:LOC102233768 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q452 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/8083:nae1 ^@ http://purl.uniprot.org/uniprot/M4AX66 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.|||Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. http://togogenome.org/gene/8083:LOC102237263 ^@ http://purl.uniprot.org/uniprot/M3ZP20 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the helicase family. PIF1 subfamily.|||DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.|||Mitochondrion|||Monomer.|||Nucleus http://togogenome.org/gene/8083:LOC102231253 ^@ http://purl.uniprot.org/uniprot/A0A3B5QJJ1 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/8083:LOC102238383 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9Z4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:LOC102232622 ^@ http://purl.uniprot.org/uniprot/A0A3B5QE21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/8083:LOC102238098 ^@ http://purl.uniprot.org/uniprot/A0A3B5PRT4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:sf3b3 ^@ http://purl.uniprot.org/uniprot/A0A3B5R2S6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:pdp1 ^@ http://purl.uniprot.org/uniprot/M4AFE3 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/8083:LOC102233495 ^@ http://purl.uniprot.org/uniprot/M3ZM26 ^@ Caution|||Similarity ^@ Belongs to the prostaglandin G/H synthase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102221212 ^@ http://purl.uniprot.org/uniprot/A0A3B5R4Q0|||http://purl.uniprot.org/uniprot/M4AX44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MOZART2 family.|||centrosome|||spindle http://togogenome.org/gene/8083:LOC102217148 ^@ http://purl.uniprot.org/uniprot/A0A3B5QT13 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/8083:wasf2 ^@ http://purl.uniprot.org/uniprot/M3ZL01 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/8083:habp2 ^@ http://purl.uniprot.org/uniprot/M3ZY18 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular space http://togogenome.org/gene/8083:bet1 ^@ http://purl.uniprot.org/uniprot/M3ZEQ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102230640 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAM9|||http://purl.uniprot.org/uniprot/A0A3B5RDB5 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/8083:galr1 ^@ http://purl.uniprot.org/uniprot/M4A3N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/8083:LOC102230296 ^@ http://purl.uniprot.org/uniprot/M4A9I8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||Lateral cell membrane|||Membrane|||Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. http://togogenome.org/gene/8083:LOC102219645 ^@ http://purl.uniprot.org/uniprot/A0A3B5R433 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/8083:gk5 ^@ http://purl.uniprot.org/uniprot/A0A3B5QSC8 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/8083:LOC102220688 ^@ http://purl.uniprot.org/uniprot/M4AEP5 ^@ Similarity ^@ Belongs to the GDNFR family. http://togogenome.org/gene/8083:rfc2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QEI6 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/8083:mtx3 ^@ http://purl.uniprot.org/uniprot/M3ZYH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/8083:LOC102230816 ^@ http://purl.uniprot.org/uniprot/M3ZZD2 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8083:LOC102218575 ^@ http://purl.uniprot.org/uniprot/M3ZQU5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:adgrl2 ^@ http://purl.uniprot.org/uniprot/A0A3B5R6U4|||http://purl.uniprot.org/uniprot/A0A3B5RE22 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:ddx10 ^@ http://purl.uniprot.org/uniprot/M4APZ6 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/8083:znrd1 ^@ http://purl.uniprot.org/uniprot/M4AGE5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.|||nucleolus http://togogenome.org/gene/8083:cct2 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q6E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102224973 ^@ http://purl.uniprot.org/uniprot/M4AI23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM120 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/8083:pycr3 ^@ http://purl.uniprot.org/uniprot/M3ZUY9 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/8083:sfmbt1 ^@ http://purl.uniprot.org/uniprot/M4A7K0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:rbm15 ^@ http://purl.uniprot.org/uniprot/M4B0J4 ^@ Similarity ^@ Belongs to the RRM Spen family. http://togogenome.org/gene/8083:upf3b ^@ http://purl.uniprot.org/uniprot/M4AGW7 ^@ Similarity ^@ Belongs to the RENT3 family. http://togogenome.org/gene/8083:arg2 ^@ http://purl.uniprot.org/uniprot/M4AK46 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/8083:LOC102232413 ^@ http://purl.uniprot.org/uniprot/M4AQN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/8083:LOC102218762 ^@ http://purl.uniprot.org/uniprot/M4ATL8 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/8083:tmem206 ^@ http://purl.uniprot.org/uniprot/M4A4U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the proton-activated chloride channel family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:cldn1 ^@ http://purl.uniprot.org/uniprot/M4AJW3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/8083:LOC102234291 ^@ http://purl.uniprot.org/uniprot/M3ZUE3 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/8083:sema6d ^@ http://purl.uniprot.org/uniprot/A0A3B5R7I8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102234441 ^@ http://purl.uniprot.org/uniprot/M4A3R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the interleukin-1 receptor family.|||Membrane|||axon|||dendrite http://togogenome.org/gene/8083:nlk ^@ http://purl.uniprot.org/uniprot/M4ACN3 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/8083:glo1 ^@ http://purl.uniprot.org/uniprot/M4ABD4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the glyoxalase I family.|||Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.|||Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. http://togogenome.org/gene/8083:asic1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QCF1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102225638 ^@ http://purl.uniprot.org/uniprot/A0A3B5QNF0|||http://purl.uniprot.org/uniprot/M3ZCU7 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/8083:jph3 ^@ http://purl.uniprot.org/uniprot/M3ZUF1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/8083:egfl6 ^@ http://purl.uniprot.org/uniprot/M3ZQE0 ^@ Caution|||Similarity ^@ Belongs to the nephronectin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102233493 ^@ http://purl.uniprot.org/uniprot/M3ZR74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/8083:pofut2 ^@ http://purl.uniprot.org/uniprot/M4ANF2 ^@ Similarity ^@ Belongs to the glycosyltransferase 68 family. http://togogenome.org/gene/8083:trappc5 ^@ http://purl.uniprot.org/uniprot/A0A3B5QL81 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||Part of the multisubunit TRAPP (transport protein particle) complex.|||cis-Golgi network http://togogenome.org/gene/8083:dusp5 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/8083:urad ^@ http://purl.uniprot.org/uniprot/M4AEL3 ^@ Function|||Similarity ^@ Belongs to the OHCU decarboxylase family.|||Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin. http://togogenome.org/gene/8083:zar1 ^@ http://purl.uniprot.org/uniprot/M4ABI2 ^@ Similarity ^@ Belongs to the ZAR1 family. http://togogenome.org/gene/8083:LOC102227775 ^@ http://purl.uniprot.org/uniprot/M3ZKW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/8083:LOC102223898 ^@ http://purl.uniprot.org/uniprot/A0A3B5R6R6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102225469 ^@ http://purl.uniprot.org/uniprot/M4ABL9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/8083:LOC102236135 ^@ http://purl.uniprot.org/uniprot/A0A3B5QRL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nectin family.|||Membrane http://togogenome.org/gene/8083:tmem183a ^@ http://purl.uniprot.org/uniprot/A0A3B5Q125 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM183 family.|||Membrane http://togogenome.org/gene/8083:pan2 ^@ http://purl.uniprot.org/uniprot/M4AB51 ^@ Activity Regulation|||Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C19 family. PAN2 subfamily.|||Binds 2 metal cations per subunit in the catalytic exonuclease domain.|||Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.|||Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.|||Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||P-body|||Positively regulated by the regulatory subunit PAN3.|||The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3. http://togogenome.org/gene/8083:LOC102221839 ^@ http://purl.uniprot.org/uniprot/M4ANB8 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/8083:atp10a ^@ http://purl.uniprot.org/uniprot/M4APB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/8083:dner ^@ http://purl.uniprot.org/uniprot/M4A8Q6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:mogs ^@ http://purl.uniprot.org/uniprot/A0A3B5PY85 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 63 family.|||Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.|||Endoplasmic reticulum membrane http://togogenome.org/gene/8083:LOC102221213 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q501 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin Y subfamily. http://togogenome.org/gene/8083:LOC102222972 ^@ http://purl.uniprot.org/uniprot/A0A3B5QIJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/8083:cd164 ^@ http://purl.uniprot.org/uniprot/A0A3B5PZ98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD164 family.|||Membrane http://togogenome.org/gene/8083:lsm1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Cytoplasm|||LSm subunits form a heteromer with a donut shape.|||P-body|||Probably involved with other LSm subunits in the general process of degradation of mRNAs. http://togogenome.org/gene/8083:pdyn ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3G3 ^@ Similarity ^@ Belongs to the opioid neuropeptide precursor family. http://togogenome.org/gene/8083:timp4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QBX9 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/8083:LOC102217371 ^@ http://purl.uniprot.org/uniprot/M4AD01 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/8083:ccnb1 ^@ http://purl.uniprot.org/uniprot/M4A2B1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. http://togogenome.org/gene/8083:rnmt ^@ http://purl.uniprot.org/uniprot/A0A3B5Q7K2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.|||In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.|||Nucleus http://togogenome.org/gene/8083:LOC102223984 ^@ http://purl.uniprot.org/uniprot/M4A3R1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.|||Membrane|||Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102234545 ^@ http://purl.uniprot.org/uniprot/M3ZFG8 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:brox ^@ http://purl.uniprot.org/uniprot/M3ZHT9 ^@ Similarity ^@ Belongs to the BROX family. http://togogenome.org/gene/8083:LOC102223539 ^@ http://purl.uniprot.org/uniprot/M3ZMC3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/8083:dram2 ^@ http://purl.uniprot.org/uniprot/M3ZUY3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102237462 ^@ http://purl.uniprot.org/uniprot/A0A3B5RCX9 ^@ Similarity ^@ Belongs to the TMEM178 family. http://togogenome.org/gene/8083:LOC102232544 ^@ http://purl.uniprot.org/uniprot/M3ZQS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Elbow/Noc family.|||Nucleus http://togogenome.org/gene/8083:ppp1r21 ^@ http://purl.uniprot.org/uniprot/M4A945 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/8083:LOC102229022 ^@ http://purl.uniprot.org/uniprot/M4AP86 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/8083:spr ^@ http://purl.uniprot.org/uniprot/M4A8F0 ^@ Similarity ^@ Belongs to the sepiapterin reductase family. http://togogenome.org/gene/8083:med25 ^@ http://purl.uniprot.org/uniprot/A0A3B5QF12 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 25 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/8083:vrk1 ^@ http://purl.uniprot.org/uniprot/M4AMM4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:LOC102229129 ^@ http://purl.uniprot.org/uniprot/M3ZVL3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S33 family.|||Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/8083:cd74 ^@ http://purl.uniprot.org/uniprot/M4A2I1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102220046 ^@ http://purl.uniprot.org/uniprot/A0A3B5QFZ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COA3 family.|||Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.|||Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.|||Membrane|||Required for assembly of cytochrome c oxidase (complex IV). http://togogenome.org/gene/8083:tekt1 ^@ http://purl.uniprot.org/uniprot/M3ZJD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||flagellum http://togogenome.org/gene/8083:pth2r ^@ http://purl.uniprot.org/uniprot/M3ZIE1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:pcnx4 ^@ http://purl.uniprot.org/uniprot/M4AGE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/8083:bud31 ^@ http://purl.uniprot.org/uniprot/M3ZN81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/8083:foxm1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVG9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:robo3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QP02 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102235773 ^@ http://purl.uniprot.org/uniprot/M4A5C1 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/8083:maco1 ^@ http://purl.uniprot.org/uniprot/M4AWJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the macoilin family.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/8083:LOC102221767 ^@ http://purl.uniprot.org/uniprot/M3ZEI8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:kiaa1024 ^@ http://purl.uniprot.org/uniprot/M4AVK8 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/8083:kcnk10 ^@ http://purl.uniprot.org/uniprot/M4ACQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/8083:LOC102220341 ^@ http://purl.uniprot.org/uniprot/M3ZKG4 ^@ Subcellular Location Annotation ^@ COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:arpc5 ^@ http://purl.uniprot.org/uniprot/A0A3B5R354 ^@ Function|||Similarity ^@ Belongs to the ARPC5 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. http://togogenome.org/gene/8083:memo1 ^@ http://purl.uniprot.org/uniprot/M3ZW33 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/8083:LOC102233620 ^@ http://purl.uniprot.org/uniprot/M4AF69 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/8083:LOC102217081 ^@ http://purl.uniprot.org/uniprot/M4A9P9 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/8083:slc12a3 ^@ http://purl.uniprot.org/uniprot/M4AMQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/8083:xpnpep1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R0T9 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/8083:fam151b ^@ http://purl.uniprot.org/uniprot/M3ZRY0 ^@ Similarity ^@ Belongs to the FAM151 family. http://togogenome.org/gene/8083:gmds ^@ http://purl.uniprot.org/uniprot/A0A3B5R3I6 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. http://togogenome.org/gene/8083:edem1 ^@ http://purl.uniprot.org/uniprot/M4AQF0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/8083:LOC102235273 ^@ http://purl.uniprot.org/uniprot/M4A2N6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/8083:LOC102236755 ^@ http://purl.uniprot.org/uniprot/M4AYC0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIIc family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102237555 ^@ http://purl.uniprot.org/uniprot/M4AT71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FIP1 family.|||Nucleus http://togogenome.org/gene/8083:LOC102224112 ^@ http://purl.uniprot.org/uniprot/M3ZH87 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/8083:eno1 ^@ http://purl.uniprot.org/uniprot/M3ZNX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102232684 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWK0 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/8083:LOC102226877 ^@ http://purl.uniprot.org/uniprot/M4AJX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cleavage furrow|||Midbody|||cilium membrane|||spindle http://togogenome.org/gene/8083:ppp2r2d ^@ http://purl.uniprot.org/uniprot/M4AE80 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/8083:LOC102218986 ^@ http://purl.uniprot.org/uniprot/M4AJM9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus|||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. http://togogenome.org/gene/8083:LOC102222479 ^@ http://purl.uniprot.org/uniprot/A0A3B5PYD8 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. http://togogenome.org/gene/8083:LOC102229229 ^@ http://purl.uniprot.org/uniprot/M3ZL17 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/8083:LOC102234082 ^@ http://purl.uniprot.org/uniprot/A0A3B5QEU8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102237092 ^@ http://purl.uniprot.org/uniprot/M4AL34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-O/MCM21 family.|||Nucleus http://togogenome.org/gene/8083:cab39 ^@ http://purl.uniprot.org/uniprot/M3ZJX9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/8083:vgll3 ^@ http://purl.uniprot.org/uniprot/M4APE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||Nucleus http://togogenome.org/gene/8083:LOC102217701 ^@ http://purl.uniprot.org/uniprot/A0A3B5PXK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Spindly family.|||Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex.|||kinetochore http://togogenome.org/gene/8083:LOC102219389 ^@ http://purl.uniprot.org/uniprot/M4AM08 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:pmpcb ^@ http://purl.uniprot.org/uniprot/A0A3B5QC99 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/8083:LOC102227399 ^@ http://purl.uniprot.org/uniprot/M4AJA4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:vps28 ^@ http://purl.uniprot.org/uniprot/M4AMV1 ^@ Function|||Similarity ^@ Belongs to the VPS28 family.|||Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. http://togogenome.org/gene/8083:LOC102237851 ^@ http://purl.uniprot.org/uniprot/M4A550 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0389 family.|||Membrane http://togogenome.org/gene/8083:LOC102228753 ^@ http://purl.uniprot.org/uniprot/M4AK54 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Mitochondrion http://togogenome.org/gene/8083:serinc5 ^@ http://purl.uniprot.org/uniprot/M3ZYN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/8083:chaf1b ^@ http://purl.uniprot.org/uniprot/M3ZPH1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102225104 ^@ http://purl.uniprot.org/uniprot/M3ZMY7 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/8083:LOC102231996 ^@ http://purl.uniprot.org/uniprot/A0A3B5PV60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity.|||Membrane http://togogenome.org/gene/8083:gpsm2 ^@ http://purl.uniprot.org/uniprot/M4A2G5 ^@ Similarity ^@ Belongs to the GPSM family. http://togogenome.org/gene/8083:LOC102216390 ^@ http://purl.uniprot.org/uniprot/M4AJ26 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/8083:LOC102223718 ^@ http://purl.uniprot.org/uniprot/M3ZQP5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:mep1b ^@ http://purl.uniprot.org/uniprot/M4ARC8 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102226437 ^@ http://purl.uniprot.org/uniprot/M4A033 ^@ Similarity ^@ Belongs to the opioid neuropeptide precursor family. http://togogenome.org/gene/8083:LOC102235446 ^@ http://purl.uniprot.org/uniprot/A0A3B5QTK0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.|||Mitochondrion http://togogenome.org/gene/8083:rap2c ^@ http://purl.uniprot.org/uniprot/A0A3B5QMA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/8083:slc37a4 ^@ http://purl.uniprot.org/uniprot/M3ZFW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/8083:LOC102218016 ^@ http://purl.uniprot.org/uniprot/M3ZPG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/8083:rbp1 ^@ http://purl.uniprot.org/uniprot/M4AWX1 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8083:olfm1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHN2|||http://purl.uniprot.org/uniprot/A0A3B5QHS7 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/8083:LOC102229303 ^@ http://purl.uniprot.org/uniprot/A0A3B5R293 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:rheb ^@ http://purl.uniprot.org/uniprot/M3ZEU8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/8083:trappc3 ^@ http://purl.uniprot.org/uniprot/M4A864 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/8083:LOC102223649 ^@ http://purl.uniprot.org/uniprot/M4A047 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/8083:cdca7 ^@ http://purl.uniprot.org/uniprot/M3ZSY5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102235830 ^@ http://purl.uniprot.org/uniprot/A0A3B5R2H1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/8083:LOC102224840 ^@ http://purl.uniprot.org/uniprot/A0A3B5R058 ^@ Similarity ^@ Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily. http://togogenome.org/gene/8083:zic1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q2A0 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/8083:cat ^@ http://purl.uniprot.org/uniprot/A0A3B5R4V4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the catalase family.|||Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.|||Peroxisome http://togogenome.org/gene/8083:LOC102225710 ^@ http://purl.uniprot.org/uniprot/M4APM2 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/8083:LOC102238251 ^@ http://purl.uniprot.org/uniprot/M4AV31 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/8083:rrn3 ^@ http://purl.uniprot.org/uniprot/M4A6Q4 ^@ Similarity ^@ Belongs to the RRN3 family. http://togogenome.org/gene/8083:xrcc3 ^@ http://purl.uniprot.org/uniprot/M3ZZC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Cytoplasm|||Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.|||Nucleus http://togogenome.org/gene/8083:LOC102221459 ^@ http://purl.uniprot.org/uniprot/M4AB16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/8083:fgf2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QTF9 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:st8sia2 ^@ http://purl.uniprot.org/uniprot/M3ZKP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8083:polr1b ^@ http://purl.uniprot.org/uniprot/M3ZZW5 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft. http://togogenome.org/gene/8083:mrpl40 ^@ http://purl.uniprot.org/uniprot/M4AJH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL40 family.|||Mitochondrion http://togogenome.org/gene/8083:glra2 ^@ http://purl.uniprot.org/uniprot/M3ZQ92 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/8083:cdk2ap1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QD72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDK2AP family.|||Nucleus http://togogenome.org/gene/8083:npc2 ^@ http://purl.uniprot.org/uniprot/M4AKJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPC2 family.|||Secreted http://togogenome.org/gene/8083:lonp2 ^@ http://purl.uniprot.org/uniprot/M3ZW32 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.|||Belongs to the peptidase S16 family.|||Peroxisome matrix http://togogenome.org/gene/8083:ndor1 ^@ http://purl.uniprot.org/uniprot/M3ZNT0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||Interacts with CIAPIN1; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair.|||perinuclear region http://togogenome.org/gene/8083:LOC102232027 ^@ http://purl.uniprot.org/uniprot/M3ZLW5 ^@ Function|||Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition. http://togogenome.org/gene/8083:map2k2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QDC0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:nup50 ^@ http://purl.uniprot.org/uniprot/M4A786 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/8083:ddx49 ^@ http://purl.uniprot.org/uniprot/M3ZK23 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/8083:LOC102217388 ^@ http://purl.uniprot.org/uniprot/M4ANW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/8083:znf330 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOA36 family.|||nucleolus http://togogenome.org/gene/8083:LOC102219219 ^@ http://purl.uniprot.org/uniprot/M3ZIF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/8083:LOC102217245 ^@ http://purl.uniprot.org/uniprot/M4A6V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CART family.|||Secreted http://togogenome.org/gene/8083:LOC102231761 ^@ http://purl.uniprot.org/uniprot/M4AYL9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:tcp11 ^@ http://purl.uniprot.org/uniprot/M4AU15 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/8083:LOC102227585 ^@ http://purl.uniprot.org/uniprot/M4AR82 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sirtuin family. Class III subfamily.|||Binds 1 zinc ion per subunit.|||In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-97 and Arg-100) that bind to malonylated and succinylated substrates and define the specificity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion|||NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.|||Nucleus|||cytosol http://togogenome.org/gene/8083:hs3st5 ^@ http://purl.uniprot.org/uniprot/M3ZSP8 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/8083:LOC102226306 ^@ http://purl.uniprot.org/uniprot/M3ZG10 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/8083:mrpl27 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWQ4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/8083:axin2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QRG9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:rybp ^@ http://purl.uniprot.org/uniprot/A0A3B5RBD8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:smad2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PN50|||http://purl.uniprot.org/uniprot/A0A3B5Q889 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:atp9b ^@ http://purl.uniprot.org/uniprot/A0A3B5QYA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/8083:LOC102221633 ^@ http://purl.uniprot.org/uniprot/M4AV17 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:etfb ^@ http://purl.uniprot.org/uniprot/A0A3B5QDD1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF beta-subunit/FixA family.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/8083:LOC102229068 ^@ http://purl.uniprot.org/uniprot/M3ZHK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INKA family.|||Nucleus http://togogenome.org/gene/8083:txnip ^@ http://purl.uniprot.org/uniprot/M3ZM32 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/8083:LOC102232033 ^@ http://purl.uniprot.org/uniprot/M3ZQJ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/8083:gprc5b ^@ http://purl.uniprot.org/uniprot/M3ZFB8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:pola2 ^@ http://purl.uniprot.org/uniprot/M4A5Q8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.|||Belongs to the DNA polymerase alpha subunit B family.|||Nucleus http://togogenome.org/gene/8083:LOC102227457 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/8083:uroc1 ^@ http://purl.uniprot.org/uniprot/M3ZHT4 ^@ Similarity ^@ Belongs to the urocanase family. http://togogenome.org/gene/8083:psma3 ^@ http://purl.uniprot.org/uniprot/M3ZRS2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/8083:LOC102236767 ^@ http://purl.uniprot.org/uniprot/M3ZXG8 ^@ Similarity ^@ Belongs to the ependymin family. http://togogenome.org/gene/8083:kpna4 ^@ http://purl.uniprot.org/uniprot/M4AVD6 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/8083:LOC106700021 ^@ http://purl.uniprot.org/uniprot/A0A3B5PSX7 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:ttc39a ^@ http://purl.uniprot.org/uniprot/A0A3B5Q962 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/8083:hebp1 ^@ http://purl.uniprot.org/uniprot/M3ZVH8 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/8083:spi1 ^@ http://purl.uniprot.org/uniprot/M3ZXH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/8083:naxe ^@ http://purl.uniprot.org/uniprot/A0A3B5REA2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NnrE/AIBP family.|||Binds 1 potassium ion per subunit.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion|||Secreted http://togogenome.org/gene/8083:p4ha3 ^@ http://purl.uniprot.org/uniprot/M4AC69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/8083:acox1 ^@ http://purl.uniprot.org/uniprot/A0A3B5RCK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/8083:fam69b ^@ http://purl.uniprot.org/uniprot/M3ZDQ2 ^@ Similarity ^@ Belongs to the DIPK family. http://togogenome.org/gene/8083:nmnat1 ^@ http://purl.uniprot.org/uniprot/M4AAQ6 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/8083:hsc70 ^@ http://purl.uniprot.org/uniprot/Q8UWM8 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/8083:LOC102220842 ^@ http://purl.uniprot.org/uniprot/A0A3B5PSA2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ELO family. ELOVL4 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Oligomer. http://togogenome.org/gene/8083:tyk2 ^@ http://purl.uniprot.org/uniprot/M3ZDE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.|||Endomembrane system http://togogenome.org/gene/8083:plau ^@ http://purl.uniprot.org/uniprot/M4A7Q1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular space http://togogenome.org/gene/8083:oxct1 ^@ http://purl.uniprot.org/uniprot/M4AN89 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 3-oxoacid CoA-transferase family.|||Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.|||Mitochondrion http://togogenome.org/gene/8083:LOC102216861 ^@ http://purl.uniprot.org/uniprot/A0A3B5R0P4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMN family.|||Cajal body|||Perikaryon|||Z line|||gem|||neuron projection http://togogenome.org/gene/8083:trmt11 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAE3 ^@ Function ^@ Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs. http://togogenome.org/gene/8083:mcoln3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQ14 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/8083:acss2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PRV4 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/8083:LOC102224254 ^@ http://purl.uniprot.org/uniprot/M4AF84 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/8083:sirt5 ^@ http://purl.uniprot.org/uniprot/A0A3B5RA54 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sirtuin family. Class III subfamily.|||Binds 1 zinc ion per subunit.|||In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-97 and Arg-100) that bind to malonylated and succinylated substrates and define the specificity.|||Mitochondrion|||NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.|||Nucleus|||cytosol http://togogenome.org/gene/8083:LOC102223212 ^@ http://purl.uniprot.org/uniprot/M4AE24 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:acap2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PRT3|||http://purl.uniprot.org/uniprot/A0A3B5PZQ1|||http://purl.uniprot.org/uniprot/A0A3B5QV64|||http://purl.uniprot.org/uniprot/M3ZU35 ^@ Activity Regulation|||Domain|||Function|||Subcellular Location Annotation ^@ Endosome membrane|||GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.|||GTPase-activating protein for the ADP ribosylation factor family.|||PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.|||The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions. http://togogenome.org/gene/8083:odr4 ^@ http://purl.uniprot.org/uniprot/M4AW75 ^@ Function|||Similarity ^@ Belongs to the ODR-4 family.|||May play a role in the trafficking of a subset of G-protein coupled receptors. http://togogenome.org/gene/8083:cdc42se2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/8083:hoxd10 ^@ http://purl.uniprot.org/uniprot/M3ZDY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/8083:sfrp2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVU6 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:eef1g ^@ http://purl.uniprot.org/uniprot/M4A6L2 ^@ Function|||Subunit ^@ EF-1 is composed of four subunits: alpha, beta, delta, and gamma.|||Probably plays a role in anchoring the complex to other cellular components. http://togogenome.org/gene/8083:serp1 ^@ http://purl.uniprot.org/uniprot/M4AHV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAMP4 family.|||Endoplasmic reticulum membrane|||May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.|||Membrane http://togogenome.org/gene/8083:LOC102225136 ^@ http://purl.uniprot.org/uniprot/M3ZG36 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/8083:LOC102218807 ^@ http://purl.uniprot.org/uniprot/M4ATZ4 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/8083:dlx5 ^@ http://purl.uniprot.org/uniprot/A0A3B5R6D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/8083:LOC102237455 ^@ http://purl.uniprot.org/uniprot/M4AHV9 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:nck1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QBG3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/8083:LOC102229117 ^@ http://purl.uniprot.org/uniprot/M4AIP9 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/8083:tbl1xr1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QNT0 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/8083:taf6 ^@ http://purl.uniprot.org/uniprot/M4ACH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF6 family.|||Nucleus http://togogenome.org/gene/8083:LOC102231791 ^@ http://purl.uniprot.org/uniprot/A0A3B5PWQ1 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/8083:LOC102227886 ^@ http://purl.uniprot.org/uniprot/A0A3B5QXT7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:c1galt1 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAG2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102231496 ^@ http://purl.uniprot.org/uniprot/M4A4K2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102235192 ^@ http://purl.uniprot.org/uniprot/M4ATM3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/8083:lztfl1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R4W9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LZTFL1 family.|||Cytoplasm|||Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.|||Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking. http://togogenome.org/gene/8083:utp23 ^@ http://purl.uniprot.org/uniprot/M4AHY8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/8083:LOC102217236 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q2S1 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/8083:cep19 ^@ http://purl.uniprot.org/uniprot/M4AA03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP19 family.|||centriole|||cilium basal body|||spindle pole http://togogenome.org/gene/8083:fam120b ^@ http://purl.uniprot.org/uniprot/M4AKA5 ^@ Similarity ^@ Belongs to the constitutive coactivator of PPAR-gamma family. http://togogenome.org/gene/8083:npr2 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q5G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane http://togogenome.org/gene/8083:LOC102236272 ^@ http://purl.uniprot.org/uniprot/M4AL62 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/8083:nr1h4 ^@ http://purl.uniprot.org/uniprot/M3ZGV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/8083:rgmb ^@ http://purl.uniprot.org/uniprot/A0A3B5Q5V1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:ndst1 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/8083:ptges3 ^@ http://purl.uniprot.org/uniprot/M4ASL1 ^@ Similarity ^@ Belongs to the p23/wos2 family. http://togogenome.org/gene/8083:LOC102235761 ^@ http://purl.uniprot.org/uniprot/M4A7B0 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/8083:gadd45a ^@ http://purl.uniprot.org/uniprot/A0A3B5R678 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/8083:LOC102221217 ^@ http://purl.uniprot.org/uniprot/M4A082 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:chga ^@ http://purl.uniprot.org/uniprot/M3ZXG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/8083:foxo1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QUH9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:lrfn1 ^@ http://purl.uniprot.org/uniprot/M4A4X4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102228635 ^@ http://purl.uniprot.org/uniprot/M4AEH1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:timp3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QR13 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/8083:orc2 ^@ http://purl.uniprot.org/uniprot/M4ABF4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC2 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Component of the origin recognition complex (ORC).|||Nucleus http://togogenome.org/gene/8083:ccdc167 ^@ http://purl.uniprot.org/uniprot/A0A3B5QXC3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102222103 ^@ http://purl.uniprot.org/uniprot/M3ZWL5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/8083:LOC102219614 ^@ http://purl.uniprot.org/uniprot/A0A3B5QY48 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/8083:LOC102227613 ^@ http://purl.uniprot.org/uniprot/A0A3B5PX86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/8083:LOC102217687 ^@ http://purl.uniprot.org/uniprot/M3ZLJ8 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/8083:rbm22 ^@ http://purl.uniprot.org/uniprot/M4A2L6 ^@ Similarity ^@ Belongs to the SLT11 family. http://togogenome.org/gene/8083:ptpra ^@ http://purl.uniprot.org/uniprot/M3ZIT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:aspn ^@ http://purl.uniprot.org/uniprot/M4A7R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||extracellular matrix http://togogenome.org/gene/8083:LOC102229795 ^@ http://purl.uniprot.org/uniprot/A0A3B5R2Z5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102237580 ^@ http://purl.uniprot.org/uniprot/M4AU20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/8083:LOC102235136 ^@ http://purl.uniprot.org/uniprot/M4A716 ^@ Subcellular Location Annotation ^@ Mitochondrion intermembrane space http://togogenome.org/gene/8083:znf830 ^@ http://purl.uniprot.org/uniprot/M4B104 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102223547 ^@ http://purl.uniprot.org/uniprot/M3ZP46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/8083:fggy ^@ http://purl.uniprot.org/uniprot/A0A3B5PVP6 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/8083:ctsl ^@ http://purl.uniprot.org/uniprot/M4AM95 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/8083:LOC102236683 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQD2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/8083:meox1 ^@ http://purl.uniprot.org/uniprot/M4ATZ2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:rplp1 ^@ http://purl.uniprot.org/uniprot/M4AM80 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/8083:ncbp3 ^@ http://purl.uniprot.org/uniprot/M3ZXD3 ^@ Similarity ^@ Belongs to the NCBP3 family. http://togogenome.org/gene/8083:tmem45a ^@ http://purl.uniprot.org/uniprot/M4ANB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/8083:aldh3b1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PXN6 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/8083:acvr2a ^@ http://purl.uniprot.org/uniprot/A0A3B5QKS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/8083:sdhaf2 ^@ http://purl.uniprot.org/uniprot/M3ZYJ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SDHAF2 family.|||Interacts with SDHA within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. http://togogenome.org/gene/8083:lcmt1 ^@ http://purl.uniprot.org/uniprot/M4ASP5 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. LCMT family.|||Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. http://togogenome.org/gene/8083:LOC102227836 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGF2 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/8083:LOC102226510 ^@ http://purl.uniprot.org/uniprot/A0A3B5QMR0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8083:LOC102229734 ^@ http://purl.uniprot.org/uniprot/M4AWR5 ^@ Similarity ^@ Belongs to the CAMK2N family. http://togogenome.org/gene/8083:LOC102219245 ^@ http://purl.uniprot.org/uniprot/A0A3B5R189 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/8083:fam168b ^@ http://purl.uniprot.org/uniprot/A0A3B5R0Z6 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/8083:LOC102217976 ^@ http://purl.uniprot.org/uniprot/A0A3B5QSJ9 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MoaE family. MOCS2B subfamily.|||Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.|||Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.|||This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2A).|||cytosol http://togogenome.org/gene/8083:hlf ^@ http://purl.uniprot.org/uniprot/M4AEN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/8083:elp6 ^@ http://purl.uniprot.org/uniprot/M4AXF3 ^@ Similarity ^@ Belongs to the ELP6 family. http://togogenome.org/gene/8083:KEG86_p11 ^@ http://purl.uniprot.org/uniprot/B5WZ53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102222655 ^@ http://purl.uniprot.org/uniprot/M4A8N8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cyclin-dependent kinase 5 activator family.|||Cell membrane|||Heterodimer of a catalytic subunit and a regulatory subunit.|||Membrane http://togogenome.org/gene/8083:LOC102218429 ^@ http://purl.uniprot.org/uniprot/M4AP45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/8083:LOC102226276 ^@ http://purl.uniprot.org/uniprot/A0A3B5QBE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:p2ry8 ^@ http://purl.uniprot.org/uniprot/A0A3B5QF73 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:pgm5 ^@ http://purl.uniprot.org/uniprot/M4AMF8 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/8083:usp49 ^@ http://purl.uniprot.org/uniprot/M3ZFT1 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/8083:c21h3orf58 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/8083:sufu ^@ http://purl.uniprot.org/uniprot/M4AGC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SUFU family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC106699989 ^@ http://purl.uniprot.org/uniprot/A0A3B5QKN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/8083:psmd5 ^@ http://purl.uniprot.org/uniprot/M3ZT50 ^@ Similarity ^@ Belongs to the proteasome subunit S5B/HSM3 family. http://togogenome.org/gene/8083:LOC102235441 ^@ http://purl.uniprot.org/uniprot/M4AD73 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/8083:slc23a1 ^@ http://purl.uniprot.org/uniprot/M3ZVM1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102222015 ^@ http://purl.uniprot.org/uniprot/A0A3B5PT76 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/8083:LOC102223135 ^@ http://purl.uniprot.org/uniprot/M4AC12 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:scg3 ^@ http://purl.uniprot.org/uniprot/M3ZIZ2 ^@ Subcellular Location Annotation ^@ Membrane|||Secreted|||secretory vesicle membrane http://togogenome.org/gene/8083:LOC102219247 ^@ http://purl.uniprot.org/uniprot/M3ZTE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/8083:nono ^@ http://purl.uniprot.org/uniprot/M4AZN6 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/8083:ctsz ^@ http://purl.uniprot.org/uniprot/M3ZMH6 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/8083:rassf5 ^@ http://purl.uniprot.org/uniprot/A0A3B5RF71 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/8083:enkd1 ^@ http://purl.uniprot.org/uniprot/M4AJB4 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/8083:LOC102230700 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q255 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:LOC102236196 ^@ http://purl.uniprot.org/uniprot/M4ADC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ISY1 family.|||Nucleus http://togogenome.org/gene/8083:LOC102232887 ^@ http://purl.uniprot.org/uniprot/M4A1Y4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:LOC102229337 ^@ http://purl.uniprot.org/uniprot/M4A025 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:ctsc ^@ http://purl.uniprot.org/uniprot/A0A3B5Q6M4 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C1 family.|||Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains. http://togogenome.org/gene/8083:LOC102227897 ^@ http://purl.uniprot.org/uniprot/M4AIC7 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/8083:urm1 ^@ http://purl.uniprot.org/uniprot/M3ZHH8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.|||Belongs to the URM1 family.|||C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.|||Cytoplasm http://togogenome.org/gene/8083:tpm1 ^@ http://purl.uniprot.org/uniprot/M3ZLR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/8083:LOC102233499 ^@ http://purl.uniprot.org/uniprot/M4ABK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:atp5md ^@ http://purl.uniprot.org/uniprot/M3ZQZ7 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion membrane http://togogenome.org/gene/8083:pax3 ^@ http://purl.uniprot.org/uniprot/M4A1H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/8083:eif3f ^@ http://purl.uniprot.org/uniprot/A0A3B5R2C1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit F family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm http://togogenome.org/gene/8083:LOC102236235 ^@ http://purl.uniprot.org/uniprot/M3ZIM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:rad1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QD76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad1 family.|||Nucleus http://togogenome.org/gene/8083:kcmf1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QR25 ^@ Function|||Similarity ^@ Belongs to the KCMF1 family.|||Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination. http://togogenome.org/gene/8083:nans ^@ http://purl.uniprot.org/uniprot/M3ZWR8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type-III AFP family.|||Contributes to protect fish blood from freezing at subzero sea water temperatures. Lowers the blood freezing point. Binds to nascent ice crystals and prevents further growth.|||Secreted http://togogenome.org/gene/8083:acvr1c ^@ http://purl.uniprot.org/uniprot/M4AA39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/8083:LOC102225458 ^@ http://purl.uniprot.org/uniprot/M3ZUK6 ^@ Similarity ^@ Belongs to the GroES chaperonin family. http://togogenome.org/gene/8083:LOC102220944 ^@ http://purl.uniprot.org/uniprot/M3ZVF9 ^@ Similarity ^@ Belongs to the SELO family. http://togogenome.org/gene/8083:ndufaf3 ^@ http://purl.uniprot.org/uniprot/A0A3B5RFN5 ^@ Function|||Subcellular Location Annotation ^@ Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Membrane|||Mitochondrion inner membrane|||Nucleus http://togogenome.org/gene/8083:rad18 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q061 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD18 family.|||Nucleus http://togogenome.org/gene/8083:LOC102233201 ^@ http://purl.uniprot.org/uniprot/A0A3B5QKU9 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/8083:fam206a ^@ http://purl.uniprot.org/uniprot/A0A3B5QV17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABITRAM family.|||growth cone|||lamellipodium http://togogenome.org/gene/8083:rida ^@ http://purl.uniprot.org/uniprot/A0A3B5QXT5 ^@ Function|||Similarity ^@ Belongs to the RutC family.|||Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. http://togogenome.org/gene/8083:LOC102221683 ^@ http://purl.uniprot.org/uniprot/M4A7G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/8083:fus ^@ http://purl.uniprot.org/uniprot/M4A964 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TET family.|||Nucleus http://togogenome.org/gene/8083:LOC102220661 ^@ http://purl.uniprot.org/uniprot/A0A3B5QC30 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102232044 ^@ http://purl.uniprot.org/uniprot/M4ASX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/8083:LOC102217337 ^@ http://purl.uniprot.org/uniprot/M4AAH7 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/8083:afmid ^@ http://purl.uniprot.org/uniprot/A0A3B5QN79 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kynurenine formamidase family.|||Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.|||Homodimer.|||Nucleus|||The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.|||cytosol http://togogenome.org/gene/8083:dapk3 ^@ http://purl.uniprot.org/uniprot/M3ZE71 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:LOC102226311 ^@ http://purl.uniprot.org/uniprot/M4AE73 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/8083:LOC102219286 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBE7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 5A family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102234430 ^@ http://purl.uniprot.org/uniprot/M3ZLD1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:pip4p2 ^@ http://purl.uniprot.org/uniprot/A0A3B5R9F1 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/8083:LOC102224930 ^@ http://purl.uniprot.org/uniprot/A0A3B5QI55 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:atpaf1 ^@ http://purl.uniprot.org/uniprot/M3ZW54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP11 family.|||Mitochondrion http://togogenome.org/gene/8083:LOC102222533 ^@ http://purl.uniprot.org/uniprot/M4A1W3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:notum ^@ http://purl.uniprot.org/uniprot/M4AD11 ^@ Similarity ^@ Belongs to the pectinacetylesterase family. Notum subfamily. http://togogenome.org/gene/8083:LOC102224266 ^@ http://purl.uniprot.org/uniprot/M4ADD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAM50/omp85 family.|||Mitochondrion outer membrane http://togogenome.org/gene/8083:b4galnt4 ^@ http://purl.uniprot.org/uniprot/A0A3B5PYB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane|||Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. http://togogenome.org/gene/8083:c12h2orf68 ^@ http://purl.uniprot.org/uniprot/M4ATM7 ^@ Similarity ^@ Belongs to the UPF0561 family. http://togogenome.org/gene/8083:alox5ap ^@ http://purl.uniprot.org/uniprot/M4A1U3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102218109 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q115 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/8083:pde3a ^@ http://purl.uniprot.org/uniprot/M4APQ6 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/8083:auh ^@ http://purl.uniprot.org/uniprot/M4ANX5 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/8083:csk ^@ http://purl.uniprot.org/uniprot/M4AQP4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/8083:triap1 ^@ http://purl.uniprot.org/uniprot/M4AYT7 ^@ Similarity ^@ Belongs to the TRIAP1/MDM35 family. http://togogenome.org/gene/8083:LOC102237495 ^@ http://purl.uniprot.org/uniprot/M4ATY6 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/8083:LOC102234041 ^@ http://purl.uniprot.org/uniprot/M4AKS9 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/8083:nip7 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q778 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NIP7 family.|||Interacts with pre-ribosome complex.|||Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.|||nucleolus http://togogenome.org/gene/8083:pomt1 ^@ http://purl.uniprot.org/uniprot/M3ZX05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/8083:LOC102233386 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZ22 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/8083:myog ^@ http://purl.uniprot.org/uniprot/M3ZNZ7 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/8083:LOC102227602 ^@ http://purl.uniprot.org/uniprot/M3ZFJ4 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/8083:LOC102221752 ^@ http://purl.uniprot.org/uniprot/M4AQE6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:smim18 ^@ http://purl.uniprot.org/uniprot/M4AZ45 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:vhl ^@ http://purl.uniprot.org/uniprot/A0A3B5QND7 ^@ Similarity ^@ Belongs to the VHL family. http://togogenome.org/gene/8083:fam167a ^@ http://purl.uniprot.org/uniprot/M3ZPZ0 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/8083:LOC102237762 ^@ http://purl.uniprot.org/uniprot/M4ALY3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:KEG86_p01 ^@ http://purl.uniprot.org/uniprot/A1YIP5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome b family.|||Binds 2 heme groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:erlec1 ^@ http://purl.uniprot.org/uniprot/M4A8Q8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OS-9 family.|||Endoplasmic reticulum lumen|||Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation. http://togogenome.org/gene/8083:p2ry6 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9J5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:cntn1 ^@ http://purl.uniprot.org/uniprot/M4A4G1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102228891 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAH2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:tmem35a ^@ http://purl.uniprot.org/uniprot/M4AGB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/8083:LOC102235059 ^@ http://purl.uniprot.org/uniprot/M4ATI0 ^@ Similarity ^@ Belongs to the synapsin family. http://togogenome.org/gene/8083:igbp1 ^@ http://purl.uniprot.org/uniprot/M4AK36 ^@ Similarity ^@ Belongs to the IGBP1/TAP42 family. http://togogenome.org/gene/8083:tmc3 ^@ http://purl.uniprot.org/uniprot/M3ZVR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/8083:LOC102228116 ^@ http://purl.uniprot.org/uniprot/A0A3B5R2Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/8083:LOC102235987 ^@ http://purl.uniprot.org/uniprot/M4AQ44 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102227777 ^@ http://purl.uniprot.org/uniprot/M3ZLD3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:hmgcll1 ^@ http://purl.uniprot.org/uniprot/M4A6W2 ^@ Similarity ^@ Belongs to the HMG-CoA lyase family. http://togogenome.org/gene/8083:LOC102219978 ^@ http://purl.uniprot.org/uniprot/M4AQI8 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8083:LOC102221408 ^@ http://purl.uniprot.org/uniprot/M3ZE96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM168 family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/8083:LOC102237875 ^@ http://purl.uniprot.org/uniprot/M3ZL10 ^@ Similarity ^@ Belongs to the EEIG family. http://togogenome.org/gene/8083:LOC102228128 ^@ http://purl.uniprot.org/uniprot/M3ZTR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:ndufaf2 ^@ http://purl.uniprot.org/uniprot/M4AMD5 ^@ Similarity ^@ Belongs to the complex I NDUFA12 subunit family. http://togogenome.org/gene/8083:LOC102224080 ^@ http://purl.uniprot.org/uniprot/M4AWE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Secreted http://togogenome.org/gene/8083:plcg1 ^@ http://purl.uniprot.org/uniprot/M4ALX9 ^@ Function ^@ Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. http://togogenome.org/gene/8083:atp6v0a2 ^@ http://purl.uniprot.org/uniprot/M4AUE3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/8083:etfa ^@ http://purl.uniprot.org/uniprot/M3ZLP3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/8083:LOC102231762 ^@ http://purl.uniprot.org/uniprot/A0A3B5QJ90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/8083:znf622 ^@ http://purl.uniprot.org/uniprot/M3ZXA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the REI1 family.|||Cytoplasm http://togogenome.org/gene/8083:nup85 ^@ http://purl.uniprot.org/uniprot/M4AJF2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup85 family.|||Component of the nuclear pore complex (NPC).|||Functions as a component of the nuclear pore complex (NPC).|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/8083:LOC102221691 ^@ http://purl.uniprot.org/uniprot/A0A3B5QFI9 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/8083:dnase2 ^@ http://purl.uniprot.org/uniprot/M4AGJ6 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/8083:LOC102219221 ^@ http://purl.uniprot.org/uniprot/A0A3B5QV19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SYG1 (TC 2.A.94) family.|||Membrane http://togogenome.org/gene/8083:LOC102228035 ^@ http://purl.uniprot.org/uniprot/M4AEP6 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/8083:alx4 ^@ http://purl.uniprot.org/uniprot/M3ZYK6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102235734 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q667 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Nematocyst|||Target cell membrane http://togogenome.org/gene/8083:grk4 ^@ http://purl.uniprot.org/uniprot/M3ZT36 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/8083:gng2 ^@ http://purl.uniprot.org/uniprot/M4AKM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/8083:tssc4 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TSSC4 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:sarm1 ^@ http://purl.uniprot.org/uniprot/M4A221 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SARM1 family.|||axon http://togogenome.org/gene/8083:LOC102225623 ^@ http://purl.uniprot.org/uniprot/A0A3B5PWL0 ^@ Caution|||Cofactor ^@ Binds 1 Fe cation per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:ptk2b ^@ http://purl.uniprot.org/uniprot/A0A3B5QKJ7 ^@ Subcellular Location Annotation ^@ Cell membrane|||focal adhesion http://togogenome.org/gene/8083:rps9 ^@ http://purl.uniprot.org/uniprot/M4ACK2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/8083:csnk2a2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QML5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:hoxc9 ^@ http://purl.uniprot.org/uniprot/M3ZHF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/8083:LOC102229203 ^@ http://purl.uniprot.org/uniprot/M4AKL9 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/8083:LOC102238351 ^@ http://purl.uniprot.org/uniprot/M3ZJG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/8083:LOC102221485 ^@ http://purl.uniprot.org/uniprot/M4ATT9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:dcn ^@ http://purl.uniprot.org/uniprot/A0A3B5R127 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.|||May affect the rate of fibrils formation.|||extracellular matrix http://togogenome.org/gene/8083:zc3h12b ^@ http://purl.uniprot.org/uniprot/M4AVT9 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/8083:iscu ^@ http://purl.uniprot.org/uniprot/M4AUT6 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/8083:tnpo1 ^@ http://purl.uniprot.org/uniprot/M3ZTE5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:eif4enif1 ^@ http://purl.uniprot.org/uniprot/M4AM96 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:rpl9 ^@ http://purl.uniprot.org/uniprot/M4A568 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/8083:rpl3 ^@ http://purl.uniprot.org/uniprot/M4AHU5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/8083:adra1d ^@ http://purl.uniprot.org/uniprot/M3ZRF7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.|||Membrane|||This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. http://togogenome.org/gene/8083:pqlc3 ^@ http://purl.uniprot.org/uniprot/M4A407 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:dpy30 ^@ http://purl.uniprot.org/uniprot/A0A3B5QV60 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/8083:LOC102226424 ^@ http://purl.uniprot.org/uniprot/M3ZN65 ^@ Similarity ^@ In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/8083:dpm3 ^@ http://purl.uniprot.org/uniprot/M4B0T8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM3 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. http://togogenome.org/gene/8083:LOC102227118 ^@ http://purl.uniprot.org/uniprot/M3ZXK7 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/8083:pcyox1 ^@ http://purl.uniprot.org/uniprot/M3ZPY4 ^@ Similarity ^@ Belongs to the prenylcysteine oxidase family. http://togogenome.org/gene/8083:LOC102219078 ^@ http://purl.uniprot.org/uniprot/M4AM16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/8083:crh ^@ http://purl.uniprot.org/uniprot/M4B0G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/8083:LOC102226842 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:dgkq ^@ http://purl.uniprot.org/uniprot/M4AM13 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/8083:lmnb2 ^@ http://purl.uniprot.org/uniprot/M4A0J6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8083:LOC102230502 ^@ http://purl.uniprot.org/uniprot/M3ZMZ1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:atp8a1 ^@ http://purl.uniprot.org/uniprot/M4AP26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/8083:kcnj13 ^@ http://purl.uniprot.org/uniprot/M4ACG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/8083:LOC102231505 ^@ http://purl.uniprot.org/uniprot/M3ZHM3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102231122 ^@ http://purl.uniprot.org/uniprot/M4A612 ^@ Function|||Similarity ^@ Belongs to the SPSB family.|||May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/8083:LOC102233800 ^@ http://purl.uniprot.org/uniprot/M3ZU47 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:tpmt ^@ http://purl.uniprot.org/uniprot/M3ZXW2 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. http://togogenome.org/gene/8083:tie1 ^@ http://purl.uniprot.org/uniprot/M4AA29 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:babam2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QFR1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BABAM2 family.|||Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.|||Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.|||Cytoplasm|||May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.|||Nucleus http://togogenome.org/gene/8083:LOC102236636 ^@ http://purl.uniprot.org/uniprot/M3ZKA5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.|||Belongs to the dynein light intermediate chain family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).|||cytoskeleton http://togogenome.org/gene/8083:ca5a ^@ http://purl.uniprot.org/uniprot/M4ANP7 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/8083:LOC102229091 ^@ http://purl.uniprot.org/uniprot/M4AJU6 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/8083:LOC102235437 ^@ http://purl.uniprot.org/uniprot/M4APR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/8083:LOC102234120 ^@ http://purl.uniprot.org/uniprot/M4A043 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/8083:wdr12 ^@ http://purl.uniprot.org/uniprot/M4AGY3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat WDR12/YTM1 family.|||Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.|||Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/8083:dhps ^@ http://purl.uniprot.org/uniprot/M4AIC8 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/8083:chmp2b ^@ http://purl.uniprot.org/uniprot/M4A2W0 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/8083:LOC102219632 ^@ http://purl.uniprot.org/uniprot/M4AB09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/8083:stx7 ^@ http://purl.uniprot.org/uniprot/M3ZXF3 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/8083:LOC102228957 ^@ http://purl.uniprot.org/uniprot/M3ZN00 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:myoz1 ^@ http://purl.uniprot.org/uniprot/M4ARI5 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/8083:LOC102223112 ^@ http://purl.uniprot.org/uniprot/M4A345 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urea transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102225239 ^@ http://purl.uniprot.org/uniprot/M4A794 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:LOC102230223 ^@ http://purl.uniprot.org/uniprot/M3ZNF5 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.|||Homotetramer. http://togogenome.org/gene/8083:LOC102216529 ^@ http://purl.uniprot.org/uniprot/A0A3B5R6A3 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with PTBP2; the interaction is direct.|||Nucleus http://togogenome.org/gene/8083:mfsd4b ^@ http://purl.uniprot.org/uniprot/M3ZE12 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102223400 ^@ http://purl.uniprot.org/uniprot/M3ZW48 ^@ Similarity ^@ Belongs to the KHDRBS family. http://togogenome.org/gene/8083:eef1akmt2 ^@ http://purl.uniprot.org/uniprot/M4ADL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.|||Cytoplasm|||Nucleus|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'. http://togogenome.org/gene/8083:rnft1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPB6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:ift43 ^@ http://purl.uniprot.org/uniprot/A0A3B5QRV5 ^@ Similarity ^@ Belongs to the IFT43 family. http://togogenome.org/gene/8083:LOC102218397 ^@ http://purl.uniprot.org/uniprot/M4AKN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/8083:atg9a ^@ http://purl.uniprot.org/uniprot/M4A5U7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG9 family.|||Membrane|||Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.|||Preautophagosomal structure membrane http://togogenome.org/gene/8083:LOC102228915 ^@ http://purl.uniprot.org/uniprot/M4A5N3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:atl1 ^@ http://purl.uniprot.org/uniprot/M4AK11 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/8083:LOC102225499 ^@ http://purl.uniprot.org/uniprot/M4AG29 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/8083:tecr ^@ http://purl.uniprot.org/uniprot/A0A3B5QBA5|||http://purl.uniprot.org/uniprot/A0A3B5RB14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102234061 ^@ http://purl.uniprot.org/uniprot/M4AJF4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8083:kxd1 ^@ http://purl.uniprot.org/uniprot/M4A3N3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KXD1 family.|||Lysosome membrane http://togogenome.org/gene/8083:gdf9 ^@ http://purl.uniprot.org/uniprot/M4A452 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/8083:nop53 ^@ http://purl.uniprot.org/uniprot/A0A3B5QRB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP53 family.|||May play a role in ribosome biogenesis.|||nucleolus|||nucleoplasm http://togogenome.org/gene/8083:coq2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QRU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102237693 ^@ http://purl.uniprot.org/uniprot/M3ZDT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:exoc1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QJ78 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/8083:rpn1 ^@ http://purl.uniprot.org/uniprot/M4AWZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/8083:rps10 ^@ http://purl.uniprot.org/uniprot/A0A3B5PY55 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS10 family. http://togogenome.org/gene/8083:slc9a3r2 ^@ http://purl.uniprot.org/uniprot/M4AEB3 ^@ Subcellular Location Annotation ^@ Endomembrane system http://togogenome.org/gene/8083:rpia ^@ http://purl.uniprot.org/uniprot/M3ZJK5 ^@ Similarity ^@ Belongs to the ribose 5-phosphate isomerase family. http://togogenome.org/gene/8083:LOC102223878 ^@ http://purl.uniprot.org/uniprot/M4A428 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/8083:LOC102231344 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q2Q3 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:slc45a4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QEQ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102216976 ^@ http://purl.uniprot.org/uniprot/M4ATM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/8083:LOC102234860 ^@ http://purl.uniprot.org/uniprot/A0A3B5PSL0 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/8083:me2 ^@ http://purl.uniprot.org/uniprot/M4ALX4 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/8083:dhh ^@ http://purl.uniprot.org/uniprot/M4A9L1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hedgehog family.|||Cell membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Multimer.|||The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.|||The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. http://togogenome.org/gene/8083:ybey ^@ http://purl.uniprot.org/uniprot/M4AKQ0 ^@ Similarity ^@ Belongs to the endoribonuclease YbeY family. http://togogenome.org/gene/8083:mcm10 ^@ http://purl.uniprot.org/uniprot/M4A2E2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM10 family.|||Nucleus http://togogenome.org/gene/8083:LOC102221862 ^@ http://purl.uniprot.org/uniprot/M4AM18 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/8083:LOC102235540 ^@ http://purl.uniprot.org/uniprot/M4ASG0 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/8083:slc2a2 ^@ http://purl.uniprot.org/uniprot/M4A3P4 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/8083:LOC102227173 ^@ http://purl.uniprot.org/uniprot/M3ZUZ0 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/8083:LOC102219757 ^@ http://purl.uniprot.org/uniprot/M3ZTE8 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/8083:LOC102236881 ^@ http://purl.uniprot.org/uniprot/M4AMR8 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:gabarap ^@ http://purl.uniprot.org/uniprot/A0A3B5R0I5 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/8083:gcat ^@ http://purl.uniprot.org/uniprot/M3ZQW3 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/8083:LOC106700472 ^@ http://purl.uniprot.org/uniprot/M4AY35 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:sap18 ^@ http://purl.uniprot.org/uniprot/A0A3B5R382 ^@ Function|||Similarity ^@ Belongs to the SAP18 family.|||Involved in the tethering of the SIN3 complex to core histone proteins. http://togogenome.org/gene/8083:LOC102219317 ^@ http://purl.uniprot.org/uniprot/M4ASC2 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/8083:cdk5r1 ^@ http://purl.uniprot.org/uniprot/M4AU52 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cyclin-dependent kinase 5 activator family.|||Cell membrane|||Heterodimer of a catalytic subunit and a regulatory subunit.|||Membrane http://togogenome.org/gene/8083:prok1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PSL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/8083:uckl1 ^@ http://purl.uniprot.org/uniprot/M4AMG2 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/8083:LOC102235774 ^@ http://purl.uniprot.org/uniprot/M4B034 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:shh ^@ http://purl.uniprot.org/uniprot/A0A3B5QCS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hedgehog family.|||Cell membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Multimer.|||The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.|||The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. http://togogenome.org/gene/8083:gba2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QDF5 ^@ Function|||Similarity ^@ Belongs to the non-lysosomal glucosylceramidase family.|||Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. http://togogenome.org/gene/8083:LOC102216532 ^@ http://purl.uniprot.org/uniprot/A0A3B5RA25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/8083:ntrk3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZY9|||http://purl.uniprot.org/uniprot/M4AUH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:abat ^@ http://purl.uniprot.org/uniprot/M3ZK35 ^@ Similarity|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/8083:rpl18a ^@ http://purl.uniprot.org/uniprot/M3ZKT6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL20 family. http://togogenome.org/gene/8083:rpap1 ^@ http://purl.uniprot.org/uniprot/M4AFT6 ^@ Similarity ^@ Belongs to the RPAP1 family. http://togogenome.org/gene/8083:LOC102227261 ^@ http://purl.uniprot.org/uniprot/A0A3B5QVK0 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.|||Nucleus http://togogenome.org/gene/8083:LOC102225979 ^@ http://purl.uniprot.org/uniprot/M4AW71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Elbow/Noc family.|||Nucleus http://togogenome.org/gene/8083:pik3r3 ^@ http://purl.uniprot.org/uniprot/M3ZT57 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/8083:LOC102229931 ^@ http://purl.uniprot.org/uniprot/A0A3B5R026 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102227123 ^@ http://purl.uniprot.org/uniprot/M4AHU7 ^@ Similarity ^@ Belongs to the cholesterol 7-desaturase family. http://togogenome.org/gene/8083:p3h1 ^@ http://purl.uniprot.org/uniprot/M3ZK80 ^@ Similarity ^@ Belongs to the leprecan family. http://togogenome.org/gene/8083:LOC102235545 ^@ http://purl.uniprot.org/uniprot/M3ZSE7 ^@ Similarity ^@ Belongs to the bZIP family. NFIL3 subfamily. http://togogenome.org/gene/8083:LOC102225103 ^@ http://purl.uniprot.org/uniprot/M3ZJE2 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/8083:LOC102226766 ^@ http://purl.uniprot.org/uniprot/A0A3B5R244 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/8083:rexo4 ^@ http://purl.uniprot.org/uniprot/A0A3B5PZH9 ^@ Similarity ^@ Belongs to the REXO4 family. http://togogenome.org/gene/8083:LOC102220419 ^@ http://purl.uniprot.org/uniprot/M4A842 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/8083:sod1 ^@ http://purl.uniprot.org/uniprot/M4AT47 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/8083:ncl ^@ http://purl.uniprot.org/uniprot/M3ZUP6 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/8083:LOC102224699 ^@ http://purl.uniprot.org/uniprot/A0A3B5QIB7 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:LOC102224871 ^@ http://purl.uniprot.org/uniprot/A0A3B5PST1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Endosome membrane|||Golgi apparatus membrane|||Late endosome membrane|||Membrane|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/8083:snrpd1 ^@ http://purl.uniprot.org/uniprot/M3ZMD6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. http://togogenome.org/gene/8083:LOC102234981 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q529 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102233284 ^@ http://purl.uniprot.org/uniprot/A0A3B5PXW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/8083:utp11 ^@ http://purl.uniprot.org/uniprot/M4AFK6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP11 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/8083:foxh1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q4X8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:npepps ^@ http://purl.uniprot.org/uniprot/M4AIM1 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/8083:parp16 ^@ http://purl.uniprot.org/uniprot/M3ZZ38 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/8083:setd3 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102229583 ^@ http://purl.uniprot.org/uniprot/M4AN31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/8083:LOC102223216 ^@ http://purl.uniprot.org/uniprot/M3ZLV9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.|||extracellular matrix http://togogenome.org/gene/8083:hapln2 ^@ http://purl.uniprot.org/uniprot/M4AFP0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:ptprg ^@ http://purl.uniprot.org/uniprot/A0A3B5Q968 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.|||Membrane http://togogenome.org/gene/8083:aqp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/8083:lipc ^@ http://purl.uniprot.org/uniprot/M4A796 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:LOC102226206 ^@ http://purl.uniprot.org/uniprot/M3ZTP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/8083:LOC102226904 ^@ http://purl.uniprot.org/uniprot/M3ZPX3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102227097 ^@ http://purl.uniprot.org/uniprot/A0A3B5R8S0 ^@ Similarity ^@ Belongs to the ric-3 family. http://togogenome.org/gene/8083:gpm6a ^@ http://purl.uniprot.org/uniprot/M3ZJ93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/8083:sema7a ^@ http://purl.uniprot.org/uniprot/A0A3B5QEW8 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:smo ^@ http://purl.uniprot.org/uniprot/M4A996 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||cilium http://togogenome.org/gene/8083:dkk3 ^@ http://purl.uniprot.org/uniprot/M3ZLQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/8083:LOC102216646 ^@ http://purl.uniprot.org/uniprot/M4AJ40 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/8083:erh ^@ http://purl.uniprot.org/uniprot/M4A423 ^@ Function|||Similarity ^@ Belongs to the E(R) family.|||May have a role in the cell cycle. http://togogenome.org/gene/8083:hgf ^@ http://purl.uniprot.org/uniprot/M3ZQC7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.|||extracellular space http://togogenome.org/gene/8083:LOC102223890 ^@ http://purl.uniprot.org/uniprot/A0A3B5QLV7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:LOC102229467 ^@ http://purl.uniprot.org/uniprot/M4AYV6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:LOC102229125 ^@ http://purl.uniprot.org/uniprot/M3ZSY7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/8083:hspa4l ^@ http://purl.uniprot.org/uniprot/M4AGJ7 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/8083:LOC102219606 ^@ http://purl.uniprot.org/uniprot/M3ZQ43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/8083:itga1 ^@ http://purl.uniprot.org/uniprot/M3ZRT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/8083:arpin ^@ http://purl.uniprot.org/uniprot/M4AN00 ^@ Similarity ^@ Belongs to the Arpin family. http://togogenome.org/gene/8083:gadd45b ^@ http://purl.uniprot.org/uniprot/M4AF13 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/8083:zfpl1 ^@ http://purl.uniprot.org/uniprot/M4AIQ3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZFPL1 family.|||Membrane|||Required for cis-Golgi integrity and efficient ER to Golgi transport.|||The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.|||cis-Golgi network membrane http://togogenome.org/gene/8083:rpf1 ^@ http://purl.uniprot.org/uniprot/M4AU68 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/8083:LOC102233075 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q988 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AMY1 family.|||Nucleus http://togogenome.org/gene/8083:LOC102234536 ^@ http://purl.uniprot.org/uniprot/M3ZDX2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lunapark family.|||Endoplasmic reticulum membrane|||Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.|||Plays a role in determining ER morphology.|||The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation. http://togogenome.org/gene/8083:prickle1 ^@ http://purl.uniprot.org/uniprot/M4ASA5 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/8083:LOC102221355 ^@ http://purl.uniprot.org/uniprot/M4A6C1 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/8083:LOC102230262 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/8083:rsg1 ^@ http://purl.uniprot.org/uniprot/M4AQH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.|||cilium basal body http://togogenome.org/gene/8083:was ^@ http://purl.uniprot.org/uniprot/M4AVG0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:lrrc4b ^@ http://purl.uniprot.org/uniprot/M4AU91 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:vipas39 ^@ http://purl.uniprot.org/uniprot/M4AGG5 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Endosome|||Late endosome http://togogenome.org/gene/8083:cul5 ^@ http://purl.uniprot.org/uniprot/M4ACW6 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/8083:LOC102230232 ^@ http://purl.uniprot.org/uniprot/A0A3B5QXC4 ^@ Similarity ^@ Belongs to the replication factor A protein 2 family. http://togogenome.org/gene/8083:LOC102232733 ^@ http://purl.uniprot.org/uniprot/M4AB67 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102226598 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQJ1 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/8083:LOC102219194 ^@ http://purl.uniprot.org/uniprot/A0A3B5PRE5 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/8083:barx2 ^@ http://purl.uniprot.org/uniprot/A0A3B5R1T9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102224275 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDG1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102237385 ^@ http://purl.uniprot.org/uniprot/M4ANI1 ^@ Similarity ^@ Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. http://togogenome.org/gene/8083:LOC102225128 ^@ http://purl.uniprot.org/uniprot/M4APL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/8083:hsd17b7 ^@ http://purl.uniprot.org/uniprot/M4ADP2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. http://togogenome.org/gene/8083:LOC102230006 ^@ http://purl.uniprot.org/uniprot/M3ZHX4 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/8083:chpf ^@ http://purl.uniprot.org/uniprot/M3ZN39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/8083:aldh1l2 ^@ http://purl.uniprot.org/uniprot/M3ZSX5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.|||In the N-terminal section; belongs to the GART family. http://togogenome.org/gene/8083:snx5 ^@ http://purl.uniprot.org/uniprot/M3ZVH0 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/8083:LOC102219607 ^@ http://purl.uniprot.org/uniprot/M4AEK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tweety family.|||Cell membrane|||Membrane|||Probable chloride channel. http://togogenome.org/gene/8083:LOC102223705 ^@ http://purl.uniprot.org/uniprot/A0A3B5PRS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane http://togogenome.org/gene/8083:LOC102232131 ^@ http://purl.uniprot.org/uniprot/M4B0R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/8083:mak16 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3V4 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/8083:hpse ^@ http://purl.uniprot.org/uniprot/M3ZDV4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/8083:LOC102225730 ^@ http://purl.uniprot.org/uniprot/M3ZLK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/8083:LOC102226292 ^@ http://purl.uniprot.org/uniprot/M4AQ60 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:msrb2 ^@ http://purl.uniprot.org/uniprot/M3ZEB2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit.|||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. http://togogenome.org/gene/8083:LOC102224968 ^@ http://purl.uniprot.org/uniprot/A0A3B5QKW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VKOR family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102231788 ^@ http://purl.uniprot.org/uniprot/M4ATR1 ^@ Similarity ^@ Belongs to the PTEN phosphatase protein family. http://togogenome.org/gene/8083:eif2a ^@ http://purl.uniprot.org/uniprot/M4AHV3 ^@ Function|||Similarity ^@ Belongs to the WD repeat EIF2A family.|||Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. http://togogenome.org/gene/8083:LOC102238257 ^@ http://purl.uniprot.org/uniprot/A0A3B5PWQ7 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/8083:LOC102234286 ^@ http://purl.uniprot.org/uniprot/M3ZDW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/8083:LOC102226826 ^@ http://purl.uniprot.org/uniprot/A0A3B5RA73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/8083:osbpl11 ^@ http://purl.uniprot.org/uniprot/M4A0H0 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/8083:LOC102231758 ^@ http://purl.uniprot.org/uniprot/M3ZJC7 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/8083:LOC102218191 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWM0 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 zinc ion per subunit.|||Homotetramer.|||Involved in the regulation of homocysteine metabolism. http://togogenome.org/gene/8083:sept6 ^@ http://purl.uniprot.org/uniprot/M4AGZ6 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/8083:creld2 ^@ http://purl.uniprot.org/uniprot/M3ZQW6 ^@ Caution|||Similarity ^@ Belongs to the CRELD family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:emx2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QUY7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:hepacam2 ^@ http://purl.uniprot.org/uniprot/M3ZEM1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102221595 ^@ http://purl.uniprot.org/uniprot/M4AIH0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:oxsr1 ^@ http://purl.uniprot.org/uniprot/A0A3B5RC05 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/8083:tbx21 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q900 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/8083:zer1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R531 ^@ Similarity ^@ Belongs to the zyg-11 family. http://togogenome.org/gene/8083:med18 ^@ http://purl.uniprot.org/uniprot/M4AJ61 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 18 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/8083:c2hxorf56 ^@ http://purl.uniprot.org/uniprot/M4AYH9 ^@ Similarity ^@ Belongs to the STEEP1 family. http://togogenome.org/gene/8083:hprt1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QD34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102218244 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0U4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8083:ccdc86 ^@ http://purl.uniprot.org/uniprot/M3ZTJ3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102234349 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1E2 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/8083:LOC102234804 ^@ http://purl.uniprot.org/uniprot/M3ZFK9 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/8083:LOC102217901 ^@ http://purl.uniprot.org/uniprot/A0A3B5PPK2 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8083:snrpd3 ^@ http://purl.uniprot.org/uniprot/M3ZFY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/8083:gpd1 ^@ http://purl.uniprot.org/uniprot/M4A7F7 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/8083:slc48a1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HRG family.|||Endosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/8083:LOC102235078 ^@ http://purl.uniprot.org/uniprot/M4ASR4 ^@ Function|||Similarity ^@ Belongs to the osteocalcin/matrix Gla protein family.|||The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein (By similarity). The carboxylated form binds strongly to apatite and calcium. http://togogenome.org/gene/8083:vps41 ^@ http://purl.uniprot.org/uniprot/M3ZIN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS41 family.|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.|||Vesicle|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/8083:LOC102217599 ^@ http://purl.uniprot.org/uniprot/M3ZWM7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102229051 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDZ0 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/8083:LOC102227530 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3S4 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/8083:LOC102234936 ^@ http://purl.uniprot.org/uniprot/A0A3B5PPJ2 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/8083:pck1 ^@ http://purl.uniprot.org/uniprot/M4A7M9 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. http://togogenome.org/gene/8083:tsr3 ^@ http://purl.uniprot.org/uniprot/M4AWW1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.|||Belongs to the TDD superfamily. TSR3 family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102231748 ^@ http://purl.uniprot.org/uniprot/M4ARB4 ^@ Similarity ^@ Belongs to the LEM family. http://togogenome.org/gene/8083:chst1 ^@ http://purl.uniprot.org/uniprot/M4B0W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/8083:ror1 ^@ http://purl.uniprot.org/uniprot/M3ZJ00 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102230860 ^@ http://purl.uniprot.org/uniprot/M3ZI04 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:gba ^@ http://purl.uniprot.org/uniprot/M4AP41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 30 family.|||Lysosome membrane http://togogenome.org/gene/8083:hspa5 ^@ http://purl.uniprot.org/uniprot/M3ZU05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/8083:abcg5 ^@ http://purl.uniprot.org/uniprot/M4AUP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/8083:LOC102228004 ^@ http://purl.uniprot.org/uniprot/M4A7N6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:phf10 ^@ http://purl.uniprot.org/uniprot/M4AKM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAYP family.|||Nucleus http://togogenome.org/gene/8083:fuz ^@ http://purl.uniprot.org/uniprot/A0A3B5QMR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fuzzy family.|||cytoskeleton http://togogenome.org/gene/8083:rpl37a ^@ http://purl.uniprot.org/uniprot/A0A3B5PVD1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/8083:LOC102225111 ^@ http://purl.uniprot.org/uniprot/M4A1Q2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:itgb5 ^@ http://purl.uniprot.org/uniprot/M3ZT61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102225810 ^@ http://purl.uniprot.org/uniprot/M3ZTF9 ^@ Similarity ^@ Belongs to the PDCD4 family. http://togogenome.org/gene/8083:gmppa ^@ http://purl.uniprot.org/uniprot/M3ZN50 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/8083:hs6st1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/8083:stk11 ^@ http://purl.uniprot.org/uniprot/M4AY33 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily. http://togogenome.org/gene/8083:tada2a ^@ http://purl.uniprot.org/uniprot/A0A3B5QWM7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:xkr6 ^@ http://purl.uniprot.org/uniprot/M3ZPX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/8083:LOC102236399 ^@ http://purl.uniprot.org/uniprot/M3ZN60 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/8083:thbs1 ^@ http://purl.uniprot.org/uniprot/M4AIQ8 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102237609 ^@ http://purl.uniprot.org/uniprot/M4AFN5 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/8083:LOC102234982 ^@ http://purl.uniprot.org/uniprot/A0A3B5PWI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/8083:ndst2 ^@ http://purl.uniprot.org/uniprot/M4AL05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/8083:LOC102232072 ^@ http://purl.uniprot.org/uniprot/A0A3B5QU97 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/8083:polr2f ^@ http://purl.uniprot.org/uniprot/M3ZH89 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.|||Nucleus http://togogenome.org/gene/8083:LOC102224485 ^@ http://purl.uniprot.org/uniprot/M3ZVD5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8083:LOC102238231 ^@ http://purl.uniprot.org/uniprot/M3ZH14 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/8083:mbd4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QSM0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:atp5po ^@ http://purl.uniprot.org/uniprot/A0A3B5Q333 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:tyms ^@ http://purl.uniprot.org/uniprot/M3ZJ50 ^@ Similarity ^@ Belongs to the thymidylate synthase family. http://togogenome.org/gene/8083:LOC102229029 ^@ http://purl.uniprot.org/uniprot/A0A3B5QXI3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.|||Cytoplasm|||Membrane http://togogenome.org/gene/8083:LOC102217224 ^@ http://purl.uniprot.org/uniprot/A0A3B5R9K2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/8083:LOC102232490 ^@ http://purl.uniprot.org/uniprot/M4AQV7 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/8083:ogn ^@ http://purl.uniprot.org/uniprot/M4A7Q8 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/8083:LOC102221911 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q7R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/8083:snap25 ^@ http://purl.uniprot.org/uniprot/A0A3B5QK98 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion.|||synaptosome http://togogenome.org/gene/8083:LOC102222176 ^@ http://purl.uniprot.org/uniprot/M4A8L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102216809 ^@ http://purl.uniprot.org/uniprot/A0A3B5QF08 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102218539 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZ74 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/8083:LOC102216664 ^@ http://purl.uniprot.org/uniprot/A0A3B5PX58 ^@ Similarity ^@ Belongs to the YOS1 family. http://togogenome.org/gene/8083:LOC102217385 ^@ http://purl.uniprot.org/uniprot/M4B0J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/8083:cdca5 ^@ http://purl.uniprot.org/uniprot/A0A3B5RB72 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/8083:yipf6 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q338 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:LOC102237234 ^@ http://purl.uniprot.org/uniprot/M4ATY2 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/8083:LOC102217770 ^@ http://purl.uniprot.org/uniprot/A0A3B5PSW9 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/8083:slc29a3 ^@ http://purl.uniprot.org/uniprot/M3ZTT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/8083:LOC102227065 ^@ http://purl.uniprot.org/uniprot/A0A3B5QFX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Secreted http://togogenome.org/gene/8083:tmem205 ^@ http://purl.uniprot.org/uniprot/A0A3B5R400 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM205 family.|||Membrane http://togogenome.org/gene/8083:ankrd34c ^@ http://purl.uniprot.org/uniprot/M4B0W9 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/8083:tagln3 ^@ http://purl.uniprot.org/uniprot/M4A5J6 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/8083:suds3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QBG9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102223630 ^@ http://purl.uniprot.org/uniprot/M3ZJH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102237988 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDD2 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/8083:LOC102237962 ^@ http://purl.uniprot.org/uniprot/M3ZXY2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:stam2 ^@ http://purl.uniprot.org/uniprot/M4ACW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane http://togogenome.org/gene/8083:psme1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R826 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/8083:adam23 ^@ http://purl.uniprot.org/uniprot/A0A3B5PTP1|||http://purl.uniprot.org/uniprot/A0A3B5QQ88 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:mindy4 ^@ http://purl.uniprot.org/uniprot/M4AVG5 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/8083:LOC102236858 ^@ http://purl.uniprot.org/uniprot/A0A3B5QY02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102220809 ^@ http://purl.uniprot.org/uniprot/M3ZM31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calreticulin family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/8083:LOC102230526 ^@ http://purl.uniprot.org/uniprot/M4AB73 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/8083:prdm12 ^@ http://purl.uniprot.org/uniprot/M3ZTK4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Involved in the positive regulation of histone H3-K9 dimethylation.|||Nucleus http://togogenome.org/gene/8083:syndig1l ^@ http://purl.uniprot.org/uniprot/M4AJ68 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/8083:e2f1 ^@ http://purl.uniprot.org/uniprot/M3ZR37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/8083:tmem86a ^@ http://purl.uniprot.org/uniprot/M4ALL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM86 family.|||Membrane http://togogenome.org/gene/8083:rpl6 ^@ http://purl.uniprot.org/uniprot/A0A3B5QLB4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/8083:sesn1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QP65|||http://purl.uniprot.org/uniprot/A0A3B5R5S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/8083:cog4 ^@ http://purl.uniprot.org/uniprot/M4AI32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG4 family.|||Golgi apparatus membrane http://togogenome.org/gene/8083:mal2 ^@ http://purl.uniprot.org/uniprot/M4A5K9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:twsg1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QRJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the twisted gastrulation protein family.|||Secreted http://togogenome.org/gene/8083:LOC102231258 ^@ http://purl.uniprot.org/uniprot/M4ATK0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity.|||Membrane http://togogenome.org/gene/8083:slc35b2 ^@ http://purl.uniprot.org/uniprot/A0A3B5R5M8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/8083:LOC102224328 ^@ http://purl.uniprot.org/uniprot/M3ZJ95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATR family.|||Membrane http://togogenome.org/gene/8083:LOC102223223 ^@ http://purl.uniprot.org/uniprot/M4AEU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/8083:LOC102235957 ^@ http://purl.uniprot.org/uniprot/A0A3B5RB88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCR4/nocturin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102217011 ^@ http://purl.uniprot.org/uniprot/M3ZSM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/8083:xpc ^@ http://purl.uniprot.org/uniprot/M4AY62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPC family.|||Nucleus http://togogenome.org/gene/8083:LOC102236680 ^@ http://purl.uniprot.org/uniprot/M4AJ39 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4.|||Belongs to the PTEN phosphatase protein family.|||Cytoplasm|||Nucleus|||PML body|||Postsynaptic density|||dendritic spine http://togogenome.org/gene/8083:ddx6 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWT4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/8083:LOC102232634 ^@ http://purl.uniprot.org/uniprot/M4ABZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:LOC102226902 ^@ http://purl.uniprot.org/uniprot/A0A3B5R5E6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:gsx1 ^@ http://purl.uniprot.org/uniprot/M4AEW0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:slc35a3 ^@ http://purl.uniprot.org/uniprot/M4AEQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:LOC102224656 ^@ http://purl.uniprot.org/uniprot/M4A3E4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:LOC102219103 ^@ http://purl.uniprot.org/uniprot/M4AK73 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102226037 ^@ http://purl.uniprot.org/uniprot/M3ZZ72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/8083:tmem145 ^@ http://purl.uniprot.org/uniprot/M3ZX19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:wnt9a ^@ http://purl.uniprot.org/uniprot/M3ZUB8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/8083:LOC102229327 ^@ http://purl.uniprot.org/uniprot/M3ZHQ7 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/8083:LOC102218615 ^@ http://purl.uniprot.org/uniprot/M4AYN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102229528 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q6S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102233404 ^@ http://purl.uniprot.org/uniprot/M3ZW37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102237952 ^@ http://purl.uniprot.org/uniprot/M3ZDU0 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:LOC102234208 ^@ http://purl.uniprot.org/uniprot/M3ZY97 ^@ Function|||Subcellular Location Annotation ^@ General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.|||Golgi apparatus|||Membrane|||Mitochondrion http://togogenome.org/gene/8083:LOC102227245 ^@ http://purl.uniprot.org/uniprot/M4AW99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/8083:LOC102228108 ^@ http://purl.uniprot.org/uniprot/M4A748 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex.|||Endoplasmic reticulum membrane|||Membrane|||The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (By similarity). The SEC61 channel associates with the multi-pass translocon (MPT) complex. http://togogenome.org/gene/8083:LOC102219004 ^@ http://purl.uniprot.org/uniprot/M4A269 ^@ Function|||Similarity ^@ Belongs to the PNP/MTAP phosphorylase family.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/8083:LOC102218327 ^@ http://purl.uniprot.org/uniprot/M4A9D9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:med22 ^@ http://purl.uniprot.org/uniprot/A0A3B5R9N6 ^@ Function|||Subcellular Location Annotation ^@ Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/8083:dhdds ^@ http://purl.uniprot.org/uniprot/M4AFS0 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/8083:lpin1 ^@ http://purl.uniprot.org/uniprot/M3ZR38 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/8083:LOC102232092 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/8083:pnoc ^@ http://purl.uniprot.org/uniprot/M4AB15 ^@ Similarity ^@ Belongs to the opioid neuropeptide precursor family. http://togogenome.org/gene/8083:hcn2 ^@ http://purl.uniprot.org/uniprot/M3ZYZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel HCN family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:itgb1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QBR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102228620 ^@ http://purl.uniprot.org/uniprot/M3ZGV0 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/8083:spdef ^@ http://purl.uniprot.org/uniprot/M4AU35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/8083:LOC102223993 ^@ http://purl.uniprot.org/uniprot/M4AE98 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/8083:kat6b ^@ http://purl.uniprot.org/uniprot/M4AM68 ^@ Similarity ^@ Belongs to the MYST (SAS/MOZ) family. http://togogenome.org/gene/8083:cdh22 ^@ http://purl.uniprot.org/uniprot/M3ZUH6 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/8083:wdr83os ^@ http://purl.uniprot.org/uniprot/M4AH54 ^@ Similarity ^@ Belongs to the Asterix family. http://togogenome.org/gene/8083:LOC102237381 ^@ http://purl.uniprot.org/uniprot/M4AA40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/8083:spsb3 ^@ http://purl.uniprot.org/uniprot/A0A3B5REL6 ^@ Function|||Similarity ^@ Belongs to the SPSB family.|||May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/8083:LOC102234345 ^@ http://purl.uniprot.org/uniprot/A0A3B5RE48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/8083:LOC102228717 ^@ http://purl.uniprot.org/uniprot/M3ZEC4 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/8083:LOC102231227 ^@ http://purl.uniprot.org/uniprot/M4ARA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/8083:gpr6 ^@ http://purl.uniprot.org/uniprot/M4AZ59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102220611 ^@ http://purl.uniprot.org/uniprot/M4A1Q6 ^@ Similarity ^@ Belongs to the pellino family. http://togogenome.org/gene/8083:acer1 ^@ http://purl.uniprot.org/uniprot/M3ZK33 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Membrane http://togogenome.org/gene/8083:LOC102219512 ^@ http://purl.uniprot.org/uniprot/M4AUU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/8083:cep57l1 ^@ http://purl.uniprot.org/uniprot/M3ZM23 ^@ Similarity ^@ Belongs to the translokin family. http://togogenome.org/gene/8083:chpf2 ^@ http://purl.uniprot.org/uniprot/M3ZIA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/8083:rad51 ^@ http://purl.uniprot.org/uniprot/M3ZEF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Nucleus|||Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair. http://togogenome.org/gene/8083:LOC102234030 ^@ http://purl.uniprot.org/uniprot/M3ZI63 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102216953 ^@ http://purl.uniprot.org/uniprot/A0A3B5QE46 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:jag2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGC1 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/8083:LOC102235336 ^@ http://purl.uniprot.org/uniprot/M4AKQ1 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/8083:fnta ^@ http://purl.uniprot.org/uniprot/M4AX18 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family. http://togogenome.org/gene/8083:lamtor3 ^@ http://purl.uniprot.org/uniprot/M4AMD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR3 family.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/8083:gad2 ^@ http://purl.uniprot.org/uniprot/M4A1I7 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/8083:pcbd2 ^@ http://purl.uniprot.org/uniprot/A0A3B5R2H3 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/8083:sbds ^@ http://purl.uniprot.org/uniprot/M3ZV42 ^@ Function|||Similarity ^@ Belongs to the SDO1/SBDS family.|||Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. http://togogenome.org/gene/8083:ndufaf1 ^@ http://purl.uniprot.org/uniprot/M3ZWX7 ^@ Function|||Similarity ^@ As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the CIA30 family. http://togogenome.org/gene/8083:traf6 ^@ http://purl.uniprot.org/uniprot/M4ABK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family. A subfamily.|||Lipid droplet|||Nucleus|||cell cortex http://togogenome.org/gene/8083:LOC102236369 ^@ http://purl.uniprot.org/uniprot/A0A3B5R693 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102223869 ^@ http://purl.uniprot.org/uniprot/A0A3B5QNF7 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:lage3 ^@ http://purl.uniprot.org/uniprot/M4APL8 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/8083:scamp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QYL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/8083:cdk5rap3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QH86 ^@ Similarity ^@ Belongs to the CDK5RAP3 family. http://togogenome.org/gene/8083:eomes ^@ http://purl.uniprot.org/uniprot/M4AIM8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/8083:grina ^@ http://purl.uniprot.org/uniprot/M3ZMF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/8083:LOC102221805 ^@ http://purl.uniprot.org/uniprot/A0A3B5QW39 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102217728 ^@ http://purl.uniprot.org/uniprot/M3ZLR3 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/8083:ythdf3 ^@ http://purl.uniprot.org/uniprot/M4A5H4 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/8083:slc45a1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QJ14 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102233713 ^@ http://purl.uniprot.org/uniprot/M3ZVR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/8083:LOC102236170 ^@ http://purl.uniprot.org/uniprot/M4AC56 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/8083:vbp1 ^@ http://purl.uniprot.org/uniprot/M3ZGX3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/8083:LOC102222797 ^@ http://purl.uniprot.org/uniprot/M4AQJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:elp5 ^@ http://purl.uniprot.org/uniprot/M4AMY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP5 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:adamts5 ^@ http://purl.uniprot.org/uniprot/A0A3B5R6E4 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/8083:tctex1d2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QRA9 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/8083:LOC102217221 ^@ http://purl.uniprot.org/uniprot/M4ATN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/8083:LOC102227235 ^@ http://purl.uniprot.org/uniprot/A0A3B5QUK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/8083:abcb9 ^@ http://purl.uniprot.org/uniprot/M4A798 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:ftsj1 ^@ http://purl.uniprot.org/uniprot/M4A4L3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.|||Cytoplasm|||Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. http://togogenome.org/gene/8083:LOC102231266 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/8083:LOC102228386 ^@ http://purl.uniprot.org/uniprot/A0A3B5PYJ1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:hamp ^@ http://purl.uniprot.org/uniprot/A0A3B5QV34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hepcidin family.|||Secreted http://togogenome.org/gene/8083:pcsk1 ^@ http://purl.uniprot.org/uniprot/M3ZTQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S8 family.|||Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.|||Vesicle|||secretory vesicle http://togogenome.org/gene/8083:LOC102232233 ^@ http://purl.uniprot.org/uniprot/M4A9W2 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/8083:LOC102220291 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1A4|||http://purl.uniprot.org/uniprot/M3ZVM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:tet2 ^@ http://purl.uniprot.org/uniprot/M3ZTA4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TET family.|||Binds 1 Fe(2+) ion per subunit.|||Chromosome|||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.|||The zinc ions have a structural role. http://togogenome.org/gene/8083:c1qbp ^@ http://purl.uniprot.org/uniprot/M3ZTZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAM33 family.|||Cell membrane http://togogenome.org/gene/8083:LOC102217251 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q322 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/8083:LOC102232076 ^@ http://purl.uniprot.org/uniprot/M4ADE8 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:adipor1 ^@ http://purl.uniprot.org/uniprot/M3ZME1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/8083:LOC102232437 ^@ http://purl.uniprot.org/uniprot/M4ANC6 ^@ Similarity ^@ Belongs to the paralemmin family. http://togogenome.org/gene/8083:lhfpl2 ^@ http://purl.uniprot.org/uniprot/M4AWE8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:igsf8 ^@ http://purl.uniprot.org/uniprot/M4ATT6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102238057 ^@ http://purl.uniprot.org/uniprot/M3ZUH1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:LOC102227657 ^@ http://purl.uniprot.org/uniprot/A0A3B5RB35 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/8083:LOC102219848 ^@ http://purl.uniprot.org/uniprot/M3ZGQ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCR10/QCR9 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102219145 ^@ http://purl.uniprot.org/uniprot/M3ZLC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the p22phox family.|||Cell membrane|||Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).|||Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.|||Membrane http://togogenome.org/gene/8083:LOC102234007 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7S3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:pop5 ^@ http://purl.uniprot.org/uniprot/M3ZMR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||nucleolus http://togogenome.org/gene/8083:lsm4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QNL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/8083:rrm2 ^@ http://purl.uniprot.org/uniprot/M4A645 ^@ Cofactor|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family.|||Binds 2 iron ions per subunit. http://togogenome.org/gene/8083:xpot ^@ http://purl.uniprot.org/uniprot/M3ZKW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus|||tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. http://togogenome.org/gene/8083:LOC102217166 ^@ http://purl.uniprot.org/uniprot/A0A3B5R4L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the P33MONOX family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102224007 ^@ http://purl.uniprot.org/uniprot/M4AGR1 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/8083:LOC102219718 ^@ http://purl.uniprot.org/uniprot/A0A3B5R3G5 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/8083:cetp ^@ http://purl.uniprot.org/uniprot/M4AMS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL.|||Secreted http://togogenome.org/gene/8083:LOC102236043 ^@ http://purl.uniprot.org/uniprot/M4ARB5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/8083:LOC102218985 ^@ http://purl.uniprot.org/uniprot/M3ZZV1 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/8083:mgrn1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PXX2|||http://purl.uniprot.org/uniprot/M3ZD32 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin ligase. http://togogenome.org/gene/8083:LOC102228380 ^@ http://purl.uniprot.org/uniprot/M4AYN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-3 subfamily.|||Nucleus http://togogenome.org/gene/8083:LOC102223671 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HARBI1 family.|||Cytoplasm|||Nucleus|||Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity. http://togogenome.org/gene/8083:LOC102236946 ^@ http://purl.uniprot.org/uniprot/M3ZX71 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/8083:mrpl15 ^@ http://purl.uniprot.org/uniprot/M3ZIP7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/8083:LOC102223132 ^@ http://purl.uniprot.org/uniprot/A0A3B5PP77 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Membrane|||Midbody|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. http://togogenome.org/gene/8083:LOC102228719 ^@ http://purl.uniprot.org/uniprot/M3ZS81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:cnot11 ^@ http://purl.uniprot.org/uniprot/M4A2J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT11 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:tomm22 ^@ http://purl.uniprot.org/uniprot/A0A3B5QME9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom22 family.|||Mitochondrion outer membrane http://togogenome.org/gene/8083:LOC102225023 ^@ http://purl.uniprot.org/uniprot/M4AEB5 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/8083:kcnj10 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q5Q7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/8083:LOC102220455 ^@ http://purl.uniprot.org/uniprot/M4A788 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/8083:olah ^@ http://purl.uniprot.org/uniprot/A0A3B5QZE0 ^@ Similarity ^@ Belongs to the thioesterase family. http://togogenome.org/gene/8083:slc6a4 ^@ http://purl.uniprot.org/uniprot/M4ACQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/8083:LOC102237991 ^@ http://purl.uniprot.org/uniprot/M4A004 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GOSR1 family.|||Component of several multiprotein Golgi SNARE complexes.|||Golgi apparatus membrane|||Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.|||Membrane http://togogenome.org/gene/8083:LOC102236757 ^@ http://purl.uniprot.org/uniprot/M3ZS83 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/8083:LOC102231175 ^@ http://purl.uniprot.org/uniprot/A0A3B5QDU4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102232405 ^@ http://purl.uniprot.org/uniprot/A0A3B5RCU1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:lpcat3 ^@ http://purl.uniprot.org/uniprot/M4A9S3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102225295 ^@ http://purl.uniprot.org/uniprot/A0A3B5PT88|||http://purl.uniprot.org/uniprot/M4A326 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.|||Membrane http://togogenome.org/gene/8083:agpat3 ^@ http://purl.uniprot.org/uniprot/M3ZN24 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/8083:LOC102219602 ^@ http://purl.uniprot.org/uniprot/A0A3B5QKK1 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/8083:c13h18orf21 ^@ http://purl.uniprot.org/uniprot/M3ZKQ6 ^@ Similarity ^@ Belongs to the UPF0711 family. http://togogenome.org/gene/8083:hoga1 ^@ http://purl.uniprot.org/uniprot/M3ZTX5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the final step in the metabolic pathway of hydroxyproline.|||Homotetramer. http://togogenome.org/gene/8083:sf3b4 ^@ http://purl.uniprot.org/uniprot/M3ZNJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B4 family.|||Nucleus http://togogenome.org/gene/8083:LOC102233408 ^@ http://purl.uniprot.org/uniprot/A0A3B5QP88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/8083:podxl2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPL3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102237444 ^@ http://purl.uniprot.org/uniprot/A0A3B5QMR6 ^@ Similarity ^@ Belongs to the HPF1 family. http://togogenome.org/gene/8083:arrb2 ^@ http://purl.uniprot.org/uniprot/M3ZWZ4 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/8083:LOC102221737 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0H5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:prep ^@ http://purl.uniprot.org/uniprot/M3ZMK7 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/8083:LOC102216818 ^@ http://purl.uniprot.org/uniprot/A0A3B5R669 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/8083:ngb ^@ http://purl.uniprot.org/uniprot/A0A3B5R106 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/8083:LOC102233419 ^@ http://purl.uniprot.org/uniprot/A0A3B5PXF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||cilium membrane http://togogenome.org/gene/8083:LOC102220384 ^@ http://purl.uniprot.org/uniprot/A0A3B5RFI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/8083:LOC102230235 ^@ http://purl.uniprot.org/uniprot/M3ZRY3 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/8083:qpctl ^@ http://purl.uniprot.org/uniprot/M3ZQ46 ^@ Similarity ^@ Belongs to the glutaminyl-peptide cyclotransferase family. http://togogenome.org/gene/8083:LOC102216396 ^@ http://purl.uniprot.org/uniprot/M3ZJ29 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102237248 ^@ http://purl.uniprot.org/uniprot/M4AWS2 ^@ Similarity ^@ Belongs to the SPSB family. http://togogenome.org/gene/8083:mpp5 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q927 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane|||tight junction http://togogenome.org/gene/8083:atp7a ^@ http://purl.uniprot.org/uniprot/M4A4J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/8083:LOC102219383 ^@ http://purl.uniprot.org/uniprot/M4AF66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/8083:rpl10a ^@ http://purl.uniprot.org/uniprot/A0A3B5Q4U9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL1 family. http://togogenome.org/gene/8083:LOC102223822 ^@ http://purl.uniprot.org/uniprot/M4AWA3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/8083:LOC102220769 ^@ http://purl.uniprot.org/uniprot/M4APY1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102222902 ^@ http://purl.uniprot.org/uniprot/M3ZZL2 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/8083:aldh1a2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PZV2 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/8083:LOC102227681 ^@ http://purl.uniprot.org/uniprot/M4AFN4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:tnfaip1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R4H5 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/8083:orai1 ^@ http://purl.uniprot.org/uniprot/M4AI04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Orai family.|||Membrane http://togogenome.org/gene/8083:pik3ip1 ^@ http://purl.uniprot.org/uniprot/M4AUF6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:gem ^@ http://purl.uniprot.org/uniprot/M4AFD3 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/8083:eral1 ^@ http://purl.uniprot.org/uniprot/M3ZTC8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Membrane|||Mitochondrion inner membrane|||Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly. http://togogenome.org/gene/8083:LOC102232035 ^@ http://purl.uniprot.org/uniprot/A0A3B5QSW5 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/8083:LOC102224294 ^@ http://purl.uniprot.org/uniprot/A0A3B5RCK0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:LOC102237928 ^@ http://purl.uniprot.org/uniprot/M4A1M6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:LOC102216449 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAH9 ^@ Similarity ^@ Belongs to the PDE6D/unc-119 family. http://togogenome.org/gene/8083:wtap ^@ http://purl.uniprot.org/uniprot/M3ZM98 ^@ Similarity ^@ Belongs to the fl(2)d family. http://togogenome.org/gene/8083:tubgcp4 ^@ http://purl.uniprot.org/uniprot/M4AUZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/8083:rab14 ^@ http://purl.uniprot.org/uniprot/M3ZSX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Recycling endosome|||phagosome|||trans-Golgi network membrane http://togogenome.org/gene/8083:LOC102224651 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYRI family.|||Membrane http://togogenome.org/gene/8083:c3h8orf37 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAN0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in photoreceptor outer segment disk morphogenesis.|||Photoreceptor inner segment http://togogenome.org/gene/8083:picalm ^@ http://purl.uniprot.org/uniprot/A0A3B5QL33 ^@ Similarity ^@ Belongs to the PICALM/SNAP91 family. http://togogenome.org/gene/8083:ankrd13a ^@ http://purl.uniprot.org/uniprot/M4AHT6 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/8083:LOC102233220 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:ppm1d ^@ http://purl.uniprot.org/uniprot/M3ZU64 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/8083:egr2 ^@ http://purl.uniprot.org/uniprot/M4AIF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/8083:aasdhppt ^@ http://purl.uniprot.org/uniprot/A0A3B5QZQ7 ^@ Similarity ^@ Belongs to the P-Pant transferase superfamily. AcpS family. http://togogenome.org/gene/8083:gtf2h5 ^@ http://purl.uniprot.org/uniprot/M3ZLW7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex.|||In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.|||Nucleus http://togogenome.org/gene/8083:kit ^@ http://purl.uniprot.org/uniprot/M4AGG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102235931 ^@ http://purl.uniprot.org/uniprot/M3ZPS1 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/8083:LOC102219344 ^@ http://purl.uniprot.org/uniprot/M3ZWX6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:aldh6a1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R685 ^@ Function|||Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. http://togogenome.org/gene/8083:LOC102237409 ^@ http://purl.uniprot.org/uniprot/M4AMN1 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/8083:ampd1 ^@ http://purl.uniprot.org/uniprot/M4A3P5 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/8083:LOC102236015 ^@ http://purl.uniprot.org/uniprot/M3ZWZ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. http://togogenome.org/gene/8083:LOC102217777 ^@ http://purl.uniprot.org/uniprot/M3ZK60 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:ache ^@ http://purl.uniprot.org/uniprot/M4ABU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Secreted http://togogenome.org/gene/8083:LOC102237728 ^@ http://purl.uniprot.org/uniprot/M3ZQJ6 ^@ Subcellular Location Annotation ^@ Cell membrane|||focal adhesion http://togogenome.org/gene/8083:LOC102233955 ^@ http://purl.uniprot.org/uniprot/A0A3B5QUV9 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/8083:pdhx ^@ http://purl.uniprot.org/uniprot/M3ZF07 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/8083:echdc2 ^@ http://purl.uniprot.org/uniprot/A0A3B5R5X7 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/8083:LOC102225599 ^@ http://purl.uniprot.org/uniprot/M4AJY7 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/8083:LOC102229399 ^@ http://purl.uniprot.org/uniprot/A0A3B5PQD1 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/8083:chek1 ^@ http://purl.uniprot.org/uniprot/M4A906 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. http://togogenome.org/gene/8083:traf4 ^@ http://purl.uniprot.org/uniprot/M4ABQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/8083:nr1h3 ^@ http://purl.uniprot.org/uniprot/M3ZCS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/8083:lrp5 ^@ http://purl.uniprot.org/uniprot/A0A3B5R4B4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102216691 ^@ http://purl.uniprot.org/uniprot/M4AHI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TORC family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102234059 ^@ http://purl.uniprot.org/uniprot/M4B0C1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:pus1 ^@ http://purl.uniprot.org/uniprot/M3ZFI9 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/8083:tspan7 ^@ http://purl.uniprot.org/uniprot/M4A9R6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:pgp ^@ http://purl.uniprot.org/uniprot/A0A3B5R505 ^@ Cofactor|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||Divalent metal ions. Mg(2+) is the most effective. http://togogenome.org/gene/8083:ak3 ^@ http://purl.uniprot.org/uniprot/M3ZGV2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK3 subfamily.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.|||Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.|||Mitochondrion matrix|||Monomer. http://togogenome.org/gene/8083:ephx1 ^@ http://purl.uniprot.org/uniprot/M4A350 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S33 family.|||Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/8083:LOC102237871 ^@ http://purl.uniprot.org/uniprot/M4ACM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/8083:LOC102236310 ^@ http://purl.uniprot.org/uniprot/M3ZY99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102223542 ^@ http://purl.uniprot.org/uniprot/M4A972 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/8083:eif2s2 ^@ http://purl.uniprot.org/uniprot/M4AXM3 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/8083:smpd1 ^@ http://purl.uniprot.org/uniprot/M4ATM0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) ions per subunit.|||Converts sphingomyelin to ceramide.|||Secreted http://togogenome.org/gene/8083:LOC102220856 ^@ http://purl.uniprot.org/uniprot/M4AAR1 ^@ Similarity ^@ Belongs to the ependymin family. http://togogenome.org/gene/8083:LOC102218392 ^@ http://purl.uniprot.org/uniprot/A0A3B5R9X3 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/8083:LOC102220709 ^@ http://purl.uniprot.org/uniprot/M4A6G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:LOC102226493 ^@ http://purl.uniprot.org/uniprot/M4ACD9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/8083:thyn1 ^@ http://purl.uniprot.org/uniprot/M4AUC5 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. http://togogenome.org/gene/8083:LOC102236782 ^@ http://purl.uniprot.org/uniprot/A0A3B5QLG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/8083:LOC102223578 ^@ http://purl.uniprot.org/uniprot/M3ZVL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:kat2b ^@ http://purl.uniprot.org/uniprot/M3ZM27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. GCN5 subfamily.|||Nucleus|||centrosome http://togogenome.org/gene/8083:slc30a1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QP58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/8083:LOC102232530 ^@ http://purl.uniprot.org/uniprot/M4A4Z7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:vps26a ^@ http://purl.uniprot.org/uniprot/M4AJC0 ^@ Similarity ^@ Belongs to the VPS26 family. http://togogenome.org/gene/8083:LOC102218554 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/8083:LOC102218491 ^@ http://purl.uniprot.org/uniprot/A0A3B5PYI3 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/8083:LOC102225036 ^@ http://purl.uniprot.org/uniprot/M4AXU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity.|||Membrane http://togogenome.org/gene/8083:pus10 ^@ http://purl.uniprot.org/uniprot/M3ZU61 ^@ Similarity ^@ Belongs to the pseudouridine synthase Pus10 family. http://togogenome.org/gene/8083:psmc3ip ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HOP2 family.|||Nucleus http://togogenome.org/gene/8083:akt2 ^@ http://purl.uniprot.org/uniprot/M4ADD6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. http://togogenome.org/gene/8083:dusp26 ^@ http://purl.uniprot.org/uniprot/M4AWG1 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of AMPK and MAPK1/2 signaling pathways.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/8083:LOC102216696 ^@ http://purl.uniprot.org/uniprot/M4AE21 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/8083:LOC102229571 ^@ http://purl.uniprot.org/uniprot/M4AKM4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 51 kDa subunit family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102235467 ^@ http://purl.uniprot.org/uniprot/A0A3B5PWD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/8083:abca3 ^@ http://purl.uniprot.org/uniprot/M3ZRH7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:fbxo9 ^@ http://purl.uniprot.org/uniprot/M4A757 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9).|||Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and acts as a regulator of mTOR signaling. http://togogenome.org/gene/8083:LOC102235902 ^@ http://purl.uniprot.org/uniprot/M4ANY3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102233959 ^@ http://purl.uniprot.org/uniprot/M3ZDZ6 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/8083:tmem256 ^@ http://purl.uniprot.org/uniprot/M4AL82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM256 family.|||Membrane http://togogenome.org/gene/8083:timp2 ^@ http://purl.uniprot.org/uniprot/M4AMQ0 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/8083:LOC102232156 ^@ http://purl.uniprot.org/uniprot/M3ZH78 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/8083:LOC102229480 ^@ http://purl.uniprot.org/uniprot/M4A8J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/8083:LOC102233797 ^@ http://purl.uniprot.org/uniprot/M4AGD8 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/8083:nop58 ^@ http://purl.uniprot.org/uniprot/M4AGW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus http://togogenome.org/gene/8083:map1lc3a ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8W3 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/8083:gap43 ^@ http://purl.uniprot.org/uniprot/M3ZL51 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neuromodulin family.|||Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.|||Cell membrane|||Membrane|||Palmitoylated. Palmitoylation is essential for plasma membrane association.|||Synapse|||This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.|||filopodium membrane|||growth cone membrane http://togogenome.org/gene/8083:dpm2 ^@ http://purl.uniprot.org/uniprot/M3ZNN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Membrane|||Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. http://togogenome.org/gene/8083:LOC102216401 ^@ http://purl.uniprot.org/uniprot/Q8UWN0 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/8083:LOC102232098 ^@ http://purl.uniprot.org/uniprot/M4AS60 ^@ Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. http://togogenome.org/gene/8083:hao1 ^@ http://purl.uniprot.org/uniprot/M4A6R4 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/8083:rpl34 ^@ http://purl.uniprot.org/uniprot/A0A3B5QVA6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/8083:LOC102223354 ^@ http://purl.uniprot.org/uniprot/A0A3B5QM10 ^@ Similarity ^@ Belongs to the RIB43A family. http://togogenome.org/gene/8083:tom1l2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PX41 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/8083:nfasc ^@ http://purl.uniprot.org/uniprot/A0A3B5QXW7|||http://purl.uniprot.org/uniprot/A0A3B5R568|||http://purl.uniprot.org/uniprot/M3ZKF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.|||Membrane http://togogenome.org/gene/8083:cmtr1 ^@ http://purl.uniprot.org/uniprot/M3ZZ78 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).|||S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. http://togogenome.org/gene/8083:LOC102233486 ^@ http://purl.uniprot.org/uniprot/M3ZSY0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOTCH family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Nucleus http://togogenome.org/gene/8083:rab29 ^@ http://purl.uniprot.org/uniprot/M4A4C7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/8083:mrpl20 ^@ http://purl.uniprot.org/uniprot/M4AQE0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family. http://togogenome.org/gene/8083:LOC102234714 ^@ http://purl.uniprot.org/uniprot/M4ARL4 ^@ Similarity ^@ Belongs to the BicD family. http://togogenome.org/gene/8083:pkd2 ^@ http://purl.uniprot.org/uniprot/M4A6D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polycystin family.|||Cell membrane|||Membrane|||cilium membrane http://togogenome.org/gene/8083:LOC102224118 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0E3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Nucleus|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/8083:LOC102228028 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUG3 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/8083:farsa ^@ http://purl.uniprot.org/uniprot/M4A322 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. http://togogenome.org/gene/8083:LOC102216737 ^@ http://purl.uniprot.org/uniprot/A0A3B5QLY3 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8083:tnfaip2 ^@ http://purl.uniprot.org/uniprot/M4AKF1 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/8083:LOC102237170 ^@ http://purl.uniprot.org/uniprot/A0A3B5R3J7 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/8083:cacng5 ^@ http://purl.uniprot.org/uniprot/A0A3B5PXH7 ^@ Similarity ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. http://togogenome.org/gene/8083:LOC102219047 ^@ http://purl.uniprot.org/uniprot/M3ZLN0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102228074 ^@ http://purl.uniprot.org/uniprot/M4AV96 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/8083:LOC102223038 ^@ http://purl.uniprot.org/uniprot/M3ZQN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Melanosome|||Membrane|||SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/8083:LOC102216463 ^@ http://purl.uniprot.org/uniprot/M3ZYR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/8083:LOC102222527 ^@ http://purl.uniprot.org/uniprot/M4AEX8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:st8sia5 ^@ http://purl.uniprot.org/uniprot/A0A3B5PTN4|||http://purl.uniprot.org/uniprot/A0A3B5RE00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8083:LOC102217219 ^@ http://purl.uniprot.org/uniprot/A0A3B5QG20|||http://purl.uniprot.org/uniprot/A0A3B5QVQ2 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/8083:atrnl1 ^@ http://purl.uniprot.org/uniprot/M4A0U5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:otx2 ^@ http://purl.uniprot.org/uniprot/M4ALI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/8083:LOC102234672 ^@ http://purl.uniprot.org/uniprot/M4ARP5 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/8083:ivd ^@ http://purl.uniprot.org/uniprot/M4AFV5 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/8083:pet117 ^@ http://purl.uniprot.org/uniprot/M4A5P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PET117 family.|||Mitochondrion http://togogenome.org/gene/8083:bcl7b ^@ http://purl.uniprot.org/uniprot/M4A8Z8 ^@ Similarity ^@ Belongs to the BCL7 family. http://togogenome.org/gene/8083:LOC102223545 ^@ http://purl.uniprot.org/uniprot/A0A3B5RCR5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/8083:LOC102237162 ^@ http://purl.uniprot.org/uniprot/M4A7Z5 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:tmem87a ^@ http://purl.uniprot.org/uniprot/A0A3B5R4T3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:mtnr1a ^@ http://purl.uniprot.org/uniprot/A0A3B5QXU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity.|||Membrane http://togogenome.org/gene/8083:LOC102233390 ^@ http://purl.uniprot.org/uniprot/M4A5K5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/8083:stam ^@ http://purl.uniprot.org/uniprot/M4AQD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane http://togogenome.org/gene/8083:LOC102223743 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7H2|||http://purl.uniprot.org/uniprot/M4AXF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SMU1 family.|||Nucleus speckle http://togogenome.org/gene/8083:LOC102238040 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9Q6 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/8083:tor4a ^@ http://purl.uniprot.org/uniprot/M3ZQJ9 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. Torsin subfamily. http://togogenome.org/gene/8083:folh1b ^@ http://purl.uniprot.org/uniprot/M4A9R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC106699830 ^@ http://purl.uniprot.org/uniprot/A0A3B5RB17 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:LOC102227590 ^@ http://purl.uniprot.org/uniprot/M4A434 ^@ Similarity ^@ Belongs to the GORASP family. http://togogenome.org/gene/8083:sap30l ^@ http://purl.uniprot.org/uniprot/A0A3B5QK99 ^@ Similarity ^@ Belongs to the SAP30 family. http://togogenome.org/gene/8083:LOC102227954 ^@ http://purl.uniprot.org/uniprot/M4AJ06 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102229905 ^@ http://purl.uniprot.org/uniprot/A0A3B5QF44 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/8083:rfng ^@ http://purl.uniprot.org/uniprot/A0A3B5R9S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:LOC102225139 ^@ http://purl.uniprot.org/uniprot/M3ZZI9 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/8083:LOC102225371 ^@ http://purl.uniprot.org/uniprot/A0A3B5QXV3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102234155 ^@ http://purl.uniprot.org/uniprot/M4ADV1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102217831 ^@ http://purl.uniprot.org/uniprot/M4AY17 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:arv1 ^@ http://purl.uniprot.org/uniprot/M3ZW17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARV1 family.|||Endoplasmic reticulum membrane|||Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.|||Membrane http://togogenome.org/gene/8083:LOC102227270 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGC2 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Plays a role in the process of neurogenesis. http://togogenome.org/gene/8083:plpp5 ^@ http://purl.uniprot.org/uniprot/M4AK18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/8083:slc25a29 ^@ http://purl.uniprot.org/uniprot/A0A3B5PXE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:LOC102234685 ^@ http://purl.uniprot.org/uniprot/M4AZF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:ewsr1 ^@ http://purl.uniprot.org/uniprot/M4AU33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TET family.|||Nucleus http://togogenome.org/gene/8083:agbl5 ^@ http://purl.uniprot.org/uniprot/M4A8W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Midbody|||Nucleus|||cytosol|||spindle http://togogenome.org/gene/8083:unc93b1 ^@ http://purl.uniprot.org/uniprot/M4ATH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/8083:LOC102219339 ^@ http://purl.uniprot.org/uniprot/M4AM28 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/8083:LOC102224848 ^@ http://purl.uniprot.org/uniprot/A0A3B5QID5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:mmgt1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R3T1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane magnesium transporter (TC 1.A.67) family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport. http://togogenome.org/gene/8083:fut8 ^@ http://purl.uniprot.org/uniprot/M4ARW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 23 family.|||Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/8083:tbxt ^@ http://purl.uniprot.org/uniprot/M4A9K3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/8083:smad1 ^@ http://purl.uniprot.org/uniprot/M4A5A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:cntd2 ^@ http://purl.uniprot.org/uniprot/M4ADC3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. http://togogenome.org/gene/8083:slc1a5 ^@ http://purl.uniprot.org/uniprot/A0A3B5R3K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/8083:LOC102227019 ^@ http://purl.uniprot.org/uniprot/M4ADK0 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/8083:LOC102230334 ^@ http://purl.uniprot.org/uniprot/M4A7H5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:setd2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QVH5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:glod4 ^@ http://purl.uniprot.org/uniprot/M4AXF9 ^@ Similarity ^@ Belongs to the glyoxalase I family. http://togogenome.org/gene/8083:suv39h1 ^@ http://purl.uniprot.org/uniprot/M4AEK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.|||Nucleus|||centromere http://togogenome.org/gene/8083:LOC102219902 ^@ http://purl.uniprot.org/uniprot/A0A3B5R3S7 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/8083:LOC102238033 ^@ http://purl.uniprot.org/uniprot/M4AQX1 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/8083:LOC102216377 ^@ http://purl.uniprot.org/uniprot/M4AFV1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/8083:LOC102231897 ^@ http://purl.uniprot.org/uniprot/M4AJ90 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/8083:tmem182 ^@ http://purl.uniprot.org/uniprot/M4AAV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM182 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102230795 ^@ http://purl.uniprot.org/uniprot/A0A3B5QEQ4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Nematocyst|||Target cell membrane http://togogenome.org/gene/8083:LOC102222361 ^@ http://purl.uniprot.org/uniprot/A0A3B5PXY9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/8083:LOC102237841 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHZ4 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/8083:LOC102217930 ^@ http://purl.uniprot.org/uniprot/A0A3B5R2S4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:pkp3 ^@ http://purl.uniprot.org/uniprot/A0A3B5RD27 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/8083:LOC102236876 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q5M1 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/8083:itih2 ^@ http://purl.uniprot.org/uniprot/M3ZLE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/8083:nkiras1 ^@ http://purl.uniprot.org/uniprot/M4ARS7 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/8083:LOC102222186 ^@ http://purl.uniprot.org/uniprot/M3ZHD0 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/8083:LOC102232916 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q354 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:eif2b2 ^@ http://purl.uniprot.org/uniprot/M3ZPA2 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/8083:sppl3 ^@ http://purl.uniprot.org/uniprot/M3ZND2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Membrane http://togogenome.org/gene/8083:dgat2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QE75 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:slc30a9 ^@ http://purl.uniprot.org/uniprot/M4AP49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Endoplasmic reticulum|||Membrane|||Mitochondrion membrane|||Nucleus http://togogenome.org/gene/8083:LOC102238060 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPP2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/8083:veph1 ^@ http://purl.uniprot.org/uniprot/M4ARW8 ^@ Similarity ^@ Belongs to the MELT/VEPH family. http://togogenome.org/gene/8083:LOC102218757 ^@ http://purl.uniprot.org/uniprot/A0A3B5R8A3 ^@ Similarity ^@ Belongs to the CRK family. http://togogenome.org/gene/8083:gpatch11 ^@ http://purl.uniprot.org/uniprot/M3ZWD6 ^@ Similarity ^@ Belongs to the GPATCH11 family. http://togogenome.org/gene/8083:gal3st1 ^@ http://purl.uniprot.org/uniprot/M3ZZT5 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/8083:LOC106699726 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBF7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:vps72 ^@ http://purl.uniprot.org/uniprot/M3ZNM0 ^@ Function|||Similarity ^@ Belongs to the VPS72/YL1 family.|||Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. http://togogenome.org/gene/8083:LOC102218543 ^@ http://purl.uniprot.org/uniprot/A0A3B5RA67 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/8083:dcp1a ^@ http://purl.uniprot.org/uniprot/A0A3B5PSG5 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/8083:cstf1 ^@ http://purl.uniprot.org/uniprot/M4AHT2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102234818 ^@ http://purl.uniprot.org/uniprot/A0A3B5RCS5 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/8083:LOC102221171 ^@ http://purl.uniprot.org/uniprot/A0A3B5PW99 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102217753 ^@ http://purl.uniprot.org/uniprot/M4A6Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/8083:azin1 ^@ http://purl.uniprot.org/uniprot/M3ZJM3 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/8083:LOC102217849 ^@ http://purl.uniprot.org/uniprot/M3ZWU0 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/8083:LOC102235073 ^@ http://purl.uniprot.org/uniprot/M3ZFM0 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/8083:sumo1 ^@ http://purl.uniprot.org/uniprot/M3ZVS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/8083:LOC102223710 ^@ http://purl.uniprot.org/uniprot/A0A3B5R200 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:lhx3 ^@ http://purl.uniprot.org/uniprot/A0A3B5PRM1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102230641 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q6D5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/8083:ppie ^@ http://purl.uniprot.org/uniprot/M4AX89 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.|||Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. http://togogenome.org/gene/8083:LOC102226850 ^@ http://purl.uniprot.org/uniprot/M3ZNA4 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/8083:serinc4 ^@ http://purl.uniprot.org/uniprot/M4AUP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/8083:LOC102221709 ^@ http://purl.uniprot.org/uniprot/M4APA4 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/8083:mrps5 ^@ http://purl.uniprot.org/uniprot/A0A3B5QRD5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/8083:tbk1 ^@ http://purl.uniprot.org/uniprot/M3ZKN7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:LOC102230982 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q084 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/8083:prps1 ^@ http://purl.uniprot.org/uniprot/M4A4Q3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/8083:LOC102232696 ^@ http://purl.uniprot.org/uniprot/M3ZTQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:mrpl12 ^@ http://purl.uniprot.org/uniprot/A0A3B5PQG9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL12 family. http://togogenome.org/gene/8083:LOC102224681 ^@ http://purl.uniprot.org/uniprot/M3ZFY7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:per1 ^@ http://purl.uniprot.org/uniprot/M4ALL0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/8083:timm50 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q818 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM50 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:prkar2b ^@ http://purl.uniprot.org/uniprot/A0A3B5QKZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102236313 ^@ http://purl.uniprot.org/uniprot/A0A3B5PP95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACC family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102224223 ^@ http://purl.uniprot.org/uniprot/M4AC72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/8083:LOC102234948 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQ95|||http://purl.uniprot.org/uniprot/A0A3B5R054 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/8083:nab1 ^@ http://purl.uniprot.org/uniprot/M4A7I2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAB family.|||Homomultimers may associate with EGR1 bound to DNA.|||Nucleus http://togogenome.org/gene/8083:bckdk ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/8083:LOC102218432 ^@ http://purl.uniprot.org/uniprot/M3ZL38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/8083:svbp ^@ http://purl.uniprot.org/uniprot/M4A5B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVBP family.|||Secreted|||cytoskeleton http://togogenome.org/gene/8083:LOC102229618 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q6Q0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:LOC102225496 ^@ http://purl.uniprot.org/uniprot/A0A3B5QP92 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8083:chrd ^@ http://purl.uniprot.org/uniprot/M4A0X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chordin family.|||Secreted http://togogenome.org/gene/8083:ero1b ^@ http://purl.uniprot.org/uniprot/M3ZKX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EROs family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/8083:gpsm1 ^@ http://purl.uniprot.org/uniprot/M4AA28 ^@ Similarity ^@ Belongs to the GPSM family. http://togogenome.org/gene/8083:LOC102219732 ^@ http://purl.uniprot.org/uniprot/M4A2M7 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/8083:rce1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase U48 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102231596 ^@ http://purl.uniprot.org/uniprot/M4ARY9 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/8083:mcub ^@ http://purl.uniprot.org/uniprot/M4A6X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCU (TC 1.A.77) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:galnt7 ^@ http://purl.uniprot.org/uniprot/M4ANF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:LOC102236096 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q4C3 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/8083:LOC102223384 ^@ http://purl.uniprot.org/uniprot/M4A0J3 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/8083:LOC102221337 ^@ http://purl.uniprot.org/uniprot/M3ZFT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:drd3 ^@ http://purl.uniprot.org/uniprot/M4A6N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:tlr5 ^@ http://purl.uniprot.org/uniprot/M3ZHU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/8083:ndufs7 ^@ http://purl.uniprot.org/uniprot/M3ZK69 ^@ Similarity ^@ Belongs to the complex I 20 kDa subunit family. http://togogenome.org/gene/8083:slc27a1 ^@ http://purl.uniprot.org/uniprot/M4AFP4 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/8083:LOC102218310 ^@ http://purl.uniprot.org/uniprot/M3ZZE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/8083:tm2d2 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q364 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102230755 ^@ http://purl.uniprot.org/uniprot/A0A3B5QRW0 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:LOC102221907 ^@ http://purl.uniprot.org/uniprot/M4AXN9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102236607 ^@ http://purl.uniprot.org/uniprot/M4ABD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/8083:fam126b ^@ http://purl.uniprot.org/uniprot/A0A3B5RF48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/8083:rgs7bp ^@ http://purl.uniprot.org/uniprot/M4AN33 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/8083:ppara ^@ http://purl.uniprot.org/uniprot/M3ZQ58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/8083:LOC102221562 ^@ http://purl.uniprot.org/uniprot/M4ACZ5 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/8083:hvcn1 ^@ http://purl.uniprot.org/uniprot/M4A941 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hydrogen channel family.|||Homodimer.|||Membrane http://togogenome.org/gene/8083:rbx1 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBZ6 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/8083:KEG86_p05 ^@ http://purl.uniprot.org/uniprot/B5WZ59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4L family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102232950 ^@ http://purl.uniprot.org/uniprot/M4ALI8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/8083:LOC102219966 ^@ http://purl.uniprot.org/uniprot/M4ANS3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transferrin family.|||Monomer.|||Secreted|||Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate. http://togogenome.org/gene/8083:LOC102237160 ^@ http://purl.uniprot.org/uniprot/M4AIS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/8083:LOC102237662 ^@ http://purl.uniprot.org/uniprot/M4A3I0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. http://togogenome.org/gene/8083:LOC102236537 ^@ http://purl.uniprot.org/uniprot/M3ZHE8 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/8083:jak1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R571 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.|||Endomembrane system http://togogenome.org/gene/8083:LOC102232758 ^@ http://purl.uniprot.org/uniprot/M4AQW6 ^@ Similarity ^@ Belongs to the GST superfamily. Theta family. http://togogenome.org/gene/8083:slc4a2 ^@ http://purl.uniprot.org/uniprot/M3ZI78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:mef2a ^@ http://purl.uniprot.org/uniprot/A0A3B5QMT1|||http://purl.uniprot.org/uniprot/A0A3B5RBH9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:msn ^@ http://purl.uniprot.org/uniprot/M4AVT6 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/8083:sgcb ^@ http://purl.uniprot.org/uniprot/A0A3B5R9S7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.|||Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/8083:gipc2 ^@ http://purl.uniprot.org/uniprot/M3ZFU3 ^@ Similarity ^@ Belongs to the GIPC family. http://togogenome.org/gene/8083:LOC102235321 ^@ http://purl.uniprot.org/uniprot/A0A3B5R0J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/8083:LOC102234752 ^@ http://purl.uniprot.org/uniprot/M3ZW35 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/8083:hoxb2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PPZ6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102224562 ^@ http://purl.uniprot.org/uniprot/A0A3B5R5Z0 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/8083:pou3f2 ^@ http://purl.uniprot.org/uniprot/A0A3B5R893 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-3 subfamily.|||Nucleus http://togogenome.org/gene/8083:LOC102231950 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q2E1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102226575 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZA4 ^@ Similarity ^@ Belongs to the LIX1 family. http://togogenome.org/gene/8083:sdad1 ^@ http://purl.uniprot.org/uniprot/M3ZQV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDA1 family.|||Required for 60S pre-ribosomal subunits export to the cytoplasm.|||nucleolus http://togogenome.org/gene/8083:LOC102219350 ^@ http://purl.uniprot.org/uniprot/M3ZWR5 ^@ Similarity|||Subunit ^@ Belongs to the CutA family.|||Homotrimer. http://togogenome.org/gene/8083:LOC102223119 ^@ http://purl.uniprot.org/uniprot/A0A3B5R991 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/8083:LOC102229019 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q322 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/8083:flt4 ^@ http://purl.uniprot.org/uniprot/M4A5J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:smc2 ^@ http://purl.uniprot.org/uniprot/M3ZQU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC2 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/8083:LOC102218880 ^@ http://purl.uniprot.org/uniprot/M3ZNI1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/8083:LOC102234753 ^@ http://purl.uniprot.org/uniprot/M4ALG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/8083:dlx2 ^@ http://purl.uniprot.org/uniprot/M3ZSD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/8083:LOC102235040 ^@ http://purl.uniprot.org/uniprot/M4A8E1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/8083:gpm6b ^@ http://purl.uniprot.org/uniprot/M3ZQA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/8083:LOC102232541 ^@ http://purl.uniprot.org/uniprot/M3ZKW1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/8083:ghitm ^@ http://purl.uniprot.org/uniprot/A0A3B5Q4C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/8083:nudt3 ^@ http://purl.uniprot.org/uniprot/M4AU62 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/8083:LOC102230345 ^@ http://purl.uniprot.org/uniprot/M4AN61 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:LOC102233270 ^@ http://purl.uniprot.org/uniprot/M3ZDH1 ^@ Cofactor ^@ Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain. http://togogenome.org/gene/8083:stk38l ^@ http://purl.uniprot.org/uniprot/A0A3B5R5U1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:LOC102235596 ^@ http://purl.uniprot.org/uniprot/A0A3B5QFL7 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/8083:med9 ^@ http://purl.uniprot.org/uniprot/A0A3B5QRE9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 9 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/8083:LOC102222236 ^@ http://purl.uniprot.org/uniprot/M4APF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/8083:trdmt1 ^@ http://purl.uniprot.org/uniprot/M3ZKS8 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/8083:LOC102237380 ^@ http://purl.uniprot.org/uniprot/M4AJL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.|||Membrane|||Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.|||sarcolemma http://togogenome.org/gene/8083:pigc ^@ http://purl.uniprot.org/uniprot/M4A9V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGC family.|||Membrane http://togogenome.org/gene/8083:otp ^@ http://purl.uniprot.org/uniprot/A0A3B5QWJ2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:nxpe3 ^@ http://purl.uniprot.org/uniprot/M4ABK1 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/8083:LOC102222706 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7H0 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/8083:dnal4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/8083:LOC102232343 ^@ http://purl.uniprot.org/uniprot/D1MGM1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:snrpa ^@ http://purl.uniprot.org/uniprot/M4AVY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM U1 A/B'' family.|||Nucleus http://togogenome.org/gene/8083:LOC102223818 ^@ http://purl.uniprot.org/uniprot/M4A9F9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/8083:rps14 ^@ http://purl.uniprot.org/uniprot/M3ZWG9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/8083:hdx ^@ http://purl.uniprot.org/uniprot/M4ABS6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:bmp4 ^@ http://purl.uniprot.org/uniprot/M3ZEW6 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/8083:LOC102231834 ^@ http://purl.uniprot.org/uniprot/M4A834 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:slc30a4 ^@ http://purl.uniprot.org/uniprot/M3ZJB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/8083:LOC102218819 ^@ http://purl.uniprot.org/uniprot/M3ZGL1 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/8083:LOC102226950 ^@ http://purl.uniprot.org/uniprot/A0A3B5RF38 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/8083:LOC106699884 ^@ http://purl.uniprot.org/uniprot/M4A5Z2 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:gtf2h1 ^@ http://purl.uniprot.org/uniprot/M3ZP65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB1 family.|||Nucleus http://togogenome.org/gene/8083:miox ^@ http://purl.uniprot.org/uniprot/M3ZPD5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the myo-inositol oxygenase family.|||Binds 2 iron ions per subunit.|||Cytoplasm http://togogenome.org/gene/8083:ppp2ca ^@ http://purl.uniprot.org/uniprot/M4A1F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102218472 ^@ http://purl.uniprot.org/uniprot/M4AJI5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102224441 ^@ http://purl.uniprot.org/uniprot/A0A3B5R698 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/8083:LOC102232917 ^@ http://purl.uniprot.org/uniprot/M3ZNH7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102236394 ^@ http://purl.uniprot.org/uniprot/A0A3B5QCY9 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/8083:gnpat ^@ http://purl.uniprot.org/uniprot/M3ZVZ4 ^@ Similarity ^@ Belongs to the GPAT/DAPAT family. http://togogenome.org/gene/8083:LOC102233635 ^@ http://purl.uniprot.org/uniprot/A0A3B5R237 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:yipf4 ^@ http://purl.uniprot.org/uniprot/M4A7U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:LOC102222884 ^@ http://purl.uniprot.org/uniprot/A0A3B5RFB2 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:cuedc2 ^@ http://purl.uniprot.org/uniprot/M3ZLH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUEDC2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:map1lc3c ^@ http://purl.uniprot.org/uniprot/M3ZEX9 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/8083:ccdc25 ^@ http://purl.uniprot.org/uniprot/M4A8R4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC25 family.|||Cell membrane|||Endomembrane system|||Interacts (via cytoplasmic region) with ILK. http://togogenome.org/gene/8083:hapln4 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8C4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102226467 ^@ http://purl.uniprot.org/uniprot/M3ZY60 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/8083:LOC102216686 ^@ http://purl.uniprot.org/uniprot/M4AI78 ^@ Similarity ^@ Belongs to the nucleobindin family. http://togogenome.org/gene/8083:cd151 ^@ http://purl.uniprot.org/uniprot/M3ZCS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:LOC102238393 ^@ http://purl.uniprot.org/uniprot/A0A3B5RC80 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/8083:LOC102227207 ^@ http://purl.uniprot.org/uniprot/A0A3B5PZ31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:LOC102225011 ^@ http://purl.uniprot.org/uniprot/M4AFG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/8083:efemp1 ^@ http://purl.uniprot.org/uniprot/M3ZL06 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102235196 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVX6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102231118 ^@ http://purl.uniprot.org/uniprot/M3ZF20 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:wdr55 ^@ http://purl.uniprot.org/uniprot/M3ZEC1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR55 family.|||Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.|||nucleolus http://togogenome.org/gene/8083:ulk3 ^@ http://purl.uniprot.org/uniprot/M4AQL0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:hoxa1 ^@ http://purl.uniprot.org/uniprot/M3ZFN3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:slc4a10 ^@ http://purl.uniprot.org/uniprot/M4AAK7 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102234132 ^@ http://purl.uniprot.org/uniprot/M3ZQ96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 75 kDa subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102218264 ^@ http://purl.uniprot.org/uniprot/M3ZKY2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102217141 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQ53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Cytoplasm|||Nucleus|||Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.|||Secreted|||cell cortex|||cytosol http://togogenome.org/gene/8083:LOC102229304 ^@ http://purl.uniprot.org/uniprot/A0A3B5PT33 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Heterodimer of a B chain and an A chain linked by two disulfide bonds.|||Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.|||Secreted http://togogenome.org/gene/8083:LOC102237998 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDY5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102224819 ^@ http://purl.uniprot.org/uniprot/M3ZSJ4 ^@ Caution|||Similarity ^@ Belongs to the prostaglandin G/H synthase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:sh3bp5l ^@ http://purl.uniprot.org/uniprot/M4AFU8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SH3BP5 family.|||Cytoplasm|||Functions as guanine nucleotide exchange factor (GEF) for RAB11A.|||Interacts with GDP-bound and nucleotide-free forms of RAB11A.|||The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape. http://togogenome.org/gene/8083:thumpd2 ^@ http://purl.uniprot.org/uniprot/M4AS35 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/8083:mtmr9 ^@ http://purl.uniprot.org/uniprot/M3ZPW1 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/8083:LOC102226854 ^@ http://purl.uniprot.org/uniprot/A0A3B5R3Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.|||Cytoplasm http://togogenome.org/gene/8083:dtnbp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVZ2 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/8083:gpn3 ^@ http://purl.uniprot.org/uniprot/M4A3T7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.|||Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/8083:LOC102224587 ^@ http://purl.uniprot.org/uniprot/M4AQI3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. http://togogenome.org/gene/8083:malrd1 ^@ http://purl.uniprot.org/uniprot/M3ZJE5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:ipo4 ^@ http://purl.uniprot.org/uniprot/M3ZV52 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:klhl21 ^@ http://purl.uniprot.org/uniprot/M4ADT6 ^@ Subcellular Location Annotation ^@ spindle http://togogenome.org/gene/8083:cnot9 ^@ http://purl.uniprot.org/uniprot/M3ZWA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT9 family.|||P-body http://togogenome.org/gene/8083:LOC102222317 ^@ http://purl.uniprot.org/uniprot/M4A673 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/8083:LOC102228916 ^@ http://purl.uniprot.org/uniprot/M4ALC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/8083:rag2 ^@ http://purl.uniprot.org/uniprot/M4B0Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAG2 family.|||Nucleus http://togogenome.org/gene/8083:paip2b ^@ http://purl.uniprot.org/uniprot/A0A3B5QB40 ^@ Similarity ^@ Belongs to the PAIP2 family. http://togogenome.org/gene/8083:usp10 ^@ http://purl.uniprot.org/uniprot/A0A3B5R0Y8 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/8083:LOC102230545 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQB0 ^@ Subcellular Location Annotation ^@ PML body|||autophagosome|||cytosol http://togogenome.org/gene/8083:ino80c ^@ http://purl.uniprot.org/uniprot/M4AJ87 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102234676 ^@ http://purl.uniprot.org/uniprot/M3ZK85 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/8083:LOC102233560 ^@ http://purl.uniprot.org/uniprot/A0A3B5R1N9 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/8083:esd ^@ http://purl.uniprot.org/uniprot/M4A4A8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the esterase D family.|||Cytoplasmic vesicle|||Serine hydrolase involved in the detoxification of formaldehyde. http://togogenome.org/gene/8083:tbc1d24 ^@ http://purl.uniprot.org/uniprot/M3ZD35 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasmic vesicle membrane|||Interacts with ARF6.|||Membrane|||Presynapse http://togogenome.org/gene/8083:LOC102217167 ^@ http://purl.uniprot.org/uniprot/A0A3B5QW41 ^@ Similarity ^@ Belongs to the YY transcription factor family. http://togogenome.org/gene/8083:sema3a ^@ http://purl.uniprot.org/uniprot/M3ZQ29 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:ddx41 ^@ http://purl.uniprot.org/uniprot/M4A5Q5 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX41 subfamily. http://togogenome.org/gene/8083:LOC102233649 ^@ http://purl.uniprot.org/uniprot/M4AWB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/8083:LOC102232185 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q6X8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Membrane|||basement membrane http://togogenome.org/gene/8083:gorasp2 ^@ http://purl.uniprot.org/uniprot/M3ZRW0 ^@ Similarity ^@ Belongs to the GORASP family. http://togogenome.org/gene/8083:ipo11 ^@ http://purl.uniprot.org/uniprot/A0A3B5R4V8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:LOC102233746 ^@ http://purl.uniprot.org/uniprot/M3ZSY9 ^@ Domain|||Similarity ^@ Belongs to the CAMSAP1 family.|||The CKK domain binds microtubules. http://togogenome.org/gene/8083:LOC102233570 ^@ http://purl.uniprot.org/uniprot/M4AZG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:vps51 ^@ http://purl.uniprot.org/uniprot/M3ZSK1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS51 family.|||Component of the Golgi-associated retrograde protein (GARP) complex. Component of the endosome-associated retrograde protein (EARP) complex.|||Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling.|||Recycling endosome|||trans-Golgi network http://togogenome.org/gene/8083:gtf2e2 ^@ http://purl.uniprot.org/uniprot/M4ACI7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFIIE beta subunit family.|||Nucleus|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.|||Tetramer of two alpha and two beta chains. http://togogenome.org/gene/8083:aspa ^@ http://purl.uniprot.org/uniprot/A0A3B5Q036 ^@ Cofactor|||Similarity ^@ Belongs to the AspA/AstE family. Aspartoacylase subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/8083:nudt21 ^@ http://purl.uniprot.org/uniprot/M4AIA5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family. CPSF5 subfamily.|||Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.|||Cytoplasm|||Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.|||Nucleus http://togogenome.org/gene/8083:LOC102219099 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1S7 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/8083:LOC102233759 ^@ http://purl.uniprot.org/uniprot/M4AEW9 ^@ Similarity ^@ Belongs to the ATPase alpha/beta chains family. http://togogenome.org/gene/8083:myrfl ^@ http://purl.uniprot.org/uniprot/A0A3B5QIY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRF family.|||Membrane http://togogenome.org/gene/8083:LOC102235575 ^@ http://purl.uniprot.org/uniprot/M3ZQV2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/8083:LOC102216590 ^@ http://purl.uniprot.org/uniprot/M3ZK44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8083:LOC102225882 ^@ http://purl.uniprot.org/uniprot/M3ZR32 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/8083:LOC102237093 ^@ http://purl.uniprot.org/uniprot/A0A3B5QG25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/8083:LOC102218728 ^@ http://purl.uniprot.org/uniprot/M4AHQ3 ^@ Similarity ^@ Belongs to the IL-6 superfamily. http://togogenome.org/gene/8083:LOC102222492 ^@ http://purl.uniprot.org/uniprot/A0A3B5QJD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/8083:ctu2 ^@ http://purl.uniprot.org/uniprot/M4AJW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTU2/NCS2 family.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. http://togogenome.org/gene/8083:LOC102231530 ^@ http://purl.uniprot.org/uniprot/M4AME4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/8083:ifrd1 ^@ http://purl.uniprot.org/uniprot/M4A3P9 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/8083:LOC102224120 ^@ http://purl.uniprot.org/uniprot/M4AKI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/8083:yipf1 ^@ http://purl.uniprot.org/uniprot/M3ZE26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Endosome membrane|||Golgi apparatus membrane|||Late endosome membrane|||Membrane|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/8083:adamts1 ^@ http://purl.uniprot.org/uniprot/M4A3X5 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/8083:LOC102225777 ^@ http://purl.uniprot.org/uniprot/A0A3B5QIB3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS19 family. http://togogenome.org/gene/8083:galnt17 ^@ http://purl.uniprot.org/uniprot/M4AFN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:srxn1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q155 ^@ Similarity ^@ Belongs to the sulfiredoxin family. http://togogenome.org/gene/8083:LOC102236785 ^@ http://purl.uniprot.org/uniprot/A0A3B5PZN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. http://togogenome.org/gene/8083:LOC102235462 ^@ http://purl.uniprot.org/uniprot/M4AEF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/8083:csrnp2 ^@ http://purl.uniprot.org/uniprot/M4AC33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/8083:LOC102218466 ^@ http://purl.uniprot.org/uniprot/M4ACU0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102220749 ^@ http://purl.uniprot.org/uniprot/M4A7N9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102223678 ^@ http://purl.uniprot.org/uniprot/M3ZIA7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:fnip1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QE12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNIP family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/8083:oca2 ^@ http://purl.uniprot.org/uniprot/M4AP15 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102230228 ^@ http://purl.uniprot.org/uniprot/M4A4G3 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/8083:LOC102227873 ^@ http://purl.uniprot.org/uniprot/M3ZTQ0 ^@ Cofactor|||Similarity ^@ Belongs to the AspA/AstE family. Aspartoacylase subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/8083:rev1 ^@ http://purl.uniprot.org/uniprot/M4AAI6 ^@ Similarity ^@ Belongs to the DNA polymerase type-Y family. http://togogenome.org/gene/8083:LOC102230798 ^@ http://purl.uniprot.org/uniprot/M4A7V6 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/8083:mrpl30 ^@ http://purl.uniprot.org/uniprot/A0A3B5PXT7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/8083:ublcp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QDI7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102237752 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q7J6 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/8083:LOC102230480 ^@ http://purl.uniprot.org/uniprot/M4A7X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Elbow/Noc family.|||Nucleus http://togogenome.org/gene/8083:sult1a4 ^@ http://purl.uniprot.org/uniprot/M4AVU7 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/8083:dtymk ^@ http://purl.uniprot.org/uniprot/M3ZNH6 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/8083:cryba2 ^@ http://purl.uniprot.org/uniprot/M3ZHW7 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:LOC102226133 ^@ http://purl.uniprot.org/uniprot/M4AF83 ^@ Similarity ^@ Belongs to the glycosyltransferase 28 family. http://togogenome.org/gene/8083:LOC102231924 ^@ http://purl.uniprot.org/uniprot/M3ZWI0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:vps33a ^@ http://purl.uniprot.org/uniprot/M3ZIG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/8083:LOC102220713 ^@ http://purl.uniprot.org/uniprot/M3ZVN4 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/8083:LOC102236051 ^@ http://purl.uniprot.org/uniprot/M3ZY65 ^@ Caution|||Similarity ^@ Belongs to the LDLR family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:tyrobp ^@ http://purl.uniprot.org/uniprot/A0A3B5PXT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TYROBP family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102222760 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPX4 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/8083:donson ^@ http://purl.uniprot.org/uniprot/M3ZQC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DONSON family.|||Nucleus http://togogenome.org/gene/8083:tmx2 ^@ http://purl.uniprot.org/uniprot/M4A5T2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/8083:LOC102218712 ^@ http://purl.uniprot.org/uniprot/A0A3B5QIG1 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8083:ppp5c ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8M6 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. http://togogenome.org/gene/8083:LOC102235205 ^@ http://purl.uniprot.org/uniprot/A0A3B5QA25 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/8083:LOC102234906 ^@ http://purl.uniprot.org/uniprot/M3ZQX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:sephs1 ^@ http://purl.uniprot.org/uniprot/M3ZR49 ^@ Function ^@ Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/8083:LOC102232835 ^@ http://purl.uniprot.org/uniprot/M3ZW19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:mrpl19 ^@ http://purl.uniprot.org/uniprot/M3ZMF9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family. http://togogenome.org/gene/8083:LOC102238386 ^@ http://purl.uniprot.org/uniprot/A0A3B5PRV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/8083:lsm5 ^@ http://purl.uniprot.org/uniprot/A0A3B5QY60 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. http://togogenome.org/gene/8083:rtca ^@ http://purl.uniprot.org/uniprot/M3ZTG1 ^@ Function|||Similarity ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. http://togogenome.org/gene/8083:il1r2 ^@ http://purl.uniprot.org/uniprot/M4AXC1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102219127 ^@ http://purl.uniprot.org/uniprot/M4AG75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX15/CtaA family.|||Membrane http://togogenome.org/gene/8083:rpl7l1 ^@ http://purl.uniprot.org/uniprot/M4A387 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/8083:LOC102231290 ^@ http://purl.uniprot.org/uniprot/M4AEE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TM6SF family.|||Membrane http://togogenome.org/gene/8083:LOC102229488 ^@ http://purl.uniprot.org/uniprot/M4AZ72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Mitochondrion outer membrane|||Presynapse|||Synapse|||axon http://togogenome.org/gene/8083:gng3 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDC0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/8083:tubg1 ^@ http://purl.uniprot.org/uniprot/M4AHD6 ^@ Function|||Similarity ^@ Belongs to the tubulin family.|||Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. http://togogenome.org/gene/8083:skp1 ^@ http://purl.uniprot.org/uniprot/M4A1F1 ^@ Function|||Similarity ^@ Belongs to the SKP1 family.|||Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. http://togogenome.org/gene/8083:vps36 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGA1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS36 family.|||Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II).|||Cytoplasm|||Endosome http://togogenome.org/gene/8083:mfsd4a ^@ http://purl.uniprot.org/uniprot/M4AP94 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:dpt ^@ http://purl.uniprot.org/uniprot/M4APP5 ^@ Similarity ^@ Belongs to the dermatopontin family. http://togogenome.org/gene/8083:chmp2a ^@ http://purl.uniprot.org/uniprot/M4AKC8 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/8083:LOC102235644 ^@ http://purl.uniprot.org/uniprot/A0A3B5R2K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-3 subfamily.|||Nucleus http://togogenome.org/gene/8083:lias ^@ http://purl.uniprot.org/uniprot/M4A576 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Mitochondrion http://togogenome.org/gene/8083:LOC102236054 ^@ http://purl.uniprot.org/uniprot/M4AVE6 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/8083:crhbp ^@ http://purl.uniprot.org/uniprot/M4AWU9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CRF-binding protein family.|||Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.|||Secreted http://togogenome.org/gene/8083:zhx1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QSZ3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:mtmr4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/8083:LOC102220256 ^@ http://purl.uniprot.org/uniprot/A0A3B5RFH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane|||Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. http://togogenome.org/gene/8083:tph1 ^@ http://purl.uniprot.org/uniprot/M3ZY44 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/8083:LOC102232380 ^@ http://purl.uniprot.org/uniprot/M3ZZN6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/8083:LOC102226951 ^@ http://purl.uniprot.org/uniprot/M3ZPA3 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/8083:LOC102229808 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q533 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/8083:LOC102226172 ^@ http://purl.uniprot.org/uniprot/M4A424 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/8083:hsd17b3 ^@ http://purl.uniprot.org/uniprot/M4AMY3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:uchl3 ^@ http://purl.uniprot.org/uniprot/M4A9C7 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/8083:tmem18 ^@ http://purl.uniprot.org/uniprot/M3ZZ80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM18 family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/8083:abcb10 ^@ http://purl.uniprot.org/uniprot/M4AKT5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102219420 ^@ http://purl.uniprot.org/uniprot/M4AC90 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. http://togogenome.org/gene/8083:LOC102236415 ^@ http://purl.uniprot.org/uniprot/M3ZIH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIP3 family.|||Membrane http://togogenome.org/gene/8083:efna5 ^@ http://purl.uniprot.org/uniprot/M4ANE5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:gosr1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQN6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GOSR1 family.|||Component of several multiprotein Golgi SNARE complexes.|||Golgi apparatus membrane|||Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.|||Membrane http://togogenome.org/gene/8083:crbn ^@ http://purl.uniprot.org/uniprot/A0A3B5QUV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRBN family.|||Nucleus http://togogenome.org/gene/8083:LOC102222432 ^@ http://purl.uniprot.org/uniprot/A0A3B5PQB1 ^@ Similarity ^@ Belongs to the MARCKS family. http://togogenome.org/gene/8083:mrpl22 ^@ http://purl.uniprot.org/uniprot/M4AMA0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/8083:LOC102234677 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAL7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Homooctamer.|||UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. http://togogenome.org/gene/8083:slc16a4 ^@ http://purl.uniprot.org/uniprot/M4A6P9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102229663 ^@ http://purl.uniprot.org/uniprot/M3ZGP3 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/8083:LOC102231419 ^@ http://purl.uniprot.org/uniprot/M4AS24 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102228480 ^@ http://purl.uniprot.org/uniprot/M4AUQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/8083:LOC102232674 ^@ http://purl.uniprot.org/uniprot/M4ALJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/8083:LOC102232902 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FGGY kinase family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102234575 ^@ http://purl.uniprot.org/uniprot/M4AB59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.|||cytoskeleton http://togogenome.org/gene/8083:slc35c2 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q4M5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102220786 ^@ http://purl.uniprot.org/uniprot/M4B016 ^@ Similarity ^@ Belongs to the NUPR family. http://togogenome.org/gene/8083:LOC102226410 ^@ http://purl.uniprot.org/uniprot/A0A3B5PT07 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/8083:nsun2 ^@ http://purl.uniprot.org/uniprot/M4AGP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||extracellular exosome http://togogenome.org/gene/8083:LOC102226075 ^@ http://purl.uniprot.org/uniprot/M4AUX8 ^@ Similarity ^@ Belongs to the CARF family. http://togogenome.org/gene/8083:LOC102220329 ^@ http://purl.uniprot.org/uniprot/M4ACW7 ^@ Similarity ^@ Belongs to the cytidylyltransferase family. http://togogenome.org/gene/8083:LOC102225454 ^@ http://purl.uniprot.org/uniprot/M4AW41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family.|||extracellular matrix http://togogenome.org/gene/8083:stk40 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q891 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.|||Nucleus http://togogenome.org/gene/8083:LOC102223376 ^@ http://purl.uniprot.org/uniprot/M3ZR22 ^@ Similarity ^@ Belongs to the GPAT/DAPAT family. http://togogenome.org/gene/8083:osbpl7 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q2K4 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/8083:kdm5c ^@ http://purl.uniprot.org/uniprot/A0A3B5QWV4 ^@ Similarity ^@ Belongs to the JARID1 histone demethylase family. http://togogenome.org/gene/8083:ubac2 ^@ http://purl.uniprot.org/uniprot/M4AUU1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:gpi ^@ http://purl.uniprot.org/uniprot/A0A3B5PSI1 ^@ Similarity ^@ Belongs to the GPI family. http://togogenome.org/gene/8083:cnp ^@ http://purl.uniprot.org/uniprot/M4A320 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 2H phosphoesterase superfamily. CNPase family.|||Exists as monomers and homodimers.|||Melanosome|||Membrane http://togogenome.org/gene/8083:LOC102229067 ^@ http://purl.uniprot.org/uniprot/M3ZIT2 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/8083:LOC102224555 ^@ http://purl.uniprot.org/uniprot/M4ARK3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102233091 ^@ http://purl.uniprot.org/uniprot/A0A3B5PW34 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:LOC102235338 ^@ http://purl.uniprot.org/uniprot/A0A3B5QMZ4|||http://purl.uniprot.org/uniprot/A0A3B5QRP8|||http://purl.uniprot.org/uniprot/M3ZH29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:slain1 ^@ http://purl.uniprot.org/uniprot/M4A9P7 ^@ Similarity ^@ Belongs to the SLAIN motif-containing family. http://togogenome.org/gene/8083:LOC102228859 ^@ http://purl.uniprot.org/uniprot/M3ZRK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/8083:kpna6 ^@ http://purl.uniprot.org/uniprot/M3ZDS0 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/8083:LOC102227009 ^@ http://purl.uniprot.org/uniprot/M3ZRL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus http://togogenome.org/gene/8083:wrnip1 ^@ http://purl.uniprot.org/uniprot/M4APJ7 ^@ Similarity ^@ Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. http://togogenome.org/gene/8083:terf2ip ^@ http://purl.uniprot.org/uniprot/M4ASB2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.|||Belongs to the RAP1 family.|||Homodimer.|||Nucleus|||telomere http://togogenome.org/gene/8083:LOC102223792 ^@ http://purl.uniprot.org/uniprot/M3ZMD0 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/8083:LOC102223665 ^@ http://purl.uniprot.org/uniprot/M3ZNW1 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/8083:pcyox1l ^@ http://purl.uniprot.org/uniprot/A0A3B5QX92 ^@ Similarity ^@ Belongs to the prenylcysteine oxidase family. http://togogenome.org/gene/8083:acly ^@ http://purl.uniprot.org/uniprot/M4A312 ^@ Function|||Similarity|||Subunit ^@ Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.|||Homotetramer.|||In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.|||In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. http://togogenome.org/gene/8083:mmd ^@ http://purl.uniprot.org/uniprot/A0A3B5QAW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/8083:LOC102225024 ^@ http://purl.uniprot.org/uniprot/M4A2G3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/8083:LOC102229933 ^@ http://purl.uniprot.org/uniprot/M3ZE63 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102225716 ^@ http://purl.uniprot.org/uniprot/M4AC83 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/8083:LOC102233463 ^@ http://purl.uniprot.org/uniprot/A0A3B5R3D2 ^@ Similarity ^@ Belongs to the PACS family. http://togogenome.org/gene/8083:hsdl2 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q561 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/8083:LOC102237375 ^@ http://purl.uniprot.org/uniprot/M4A113 ^@ Similarity ^@ Belongs to the pellino family. http://togogenome.org/gene/8083:ddr2 ^@ http://purl.uniprot.org/uniprot/M4AB99 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102235711 ^@ http://purl.uniprot.org/uniprot/M4AJR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/8083:LOC102234690 ^@ http://purl.uniprot.org/uniprot/M4APV6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:rpl32 ^@ http://purl.uniprot.org/uniprot/A0A3B5R009 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/8083:LOC102234316 ^@ http://purl.uniprot.org/uniprot/M3ZHB7 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/8083:LOC102232703 ^@ http://purl.uniprot.org/uniprot/M4ANF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/8083:naga ^@ http://purl.uniprot.org/uniprot/A0A3B5PN84 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/8083:sidt2 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q587 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SID1 family.|||Membrane http://togogenome.org/gene/8083:LOC102227614 ^@ http://purl.uniprot.org/uniprot/M3ZZR9 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/8083:LOC102224067 ^@ http://purl.uniprot.org/uniprot/M3ZQK9 ^@ Similarity ^@ Belongs to the YOS1 family. http://togogenome.org/gene/8083:LOC102236441 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVW0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102230114 ^@ http://purl.uniprot.org/uniprot/M4A6X6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/8083:ada ^@ http://purl.uniprot.org/uniprot/M3ZGB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Cell junction|||Cell membrane|||Cytoplasmic vesicle lumen http://togogenome.org/gene/8083:LOC102231918 ^@ http://purl.uniprot.org/uniprot/M4AQH6 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/8083:inpp4a ^@ http://purl.uniprot.org/uniprot/A0A3B5R791 ^@ Similarity ^@ Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. http://togogenome.org/gene/8083:LOC102237445 ^@ http://purl.uniprot.org/uniprot/M4AZ40 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/8083:rps19bp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QEE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AROS family.|||nucleolus http://togogenome.org/gene/8083:creb1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZI0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:rpl30 ^@ http://purl.uniprot.org/uniprot/M3ZNA7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/8083:ada2 ^@ http://purl.uniprot.org/uniprot/M3ZT62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.|||Secreted http://togogenome.org/gene/8083:LOC102235779 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/8083:LOC102218036 ^@ http://purl.uniprot.org/uniprot/M3ZU56 ^@ Similarity ^@ Belongs to the CCDC149 family. http://togogenome.org/gene/8083:LOC102219491 ^@ http://purl.uniprot.org/uniprot/M4AUF9 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits. http://togogenome.org/gene/8083:prkcd ^@ http://purl.uniprot.org/uniprot/A0A3B5RFP1 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.|||Cytoplasm|||Interacts with PDPK1 (via N-terminal region), RAD9A, CDCP1, MUC1 and VASP.|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.|||Nucleus|||perinuclear region http://togogenome.org/gene/8083:btf3 ^@ http://purl.uniprot.org/uniprot/M4A3R9 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/8083:LOC102225395 ^@ http://purl.uniprot.org/uniprot/M3ZD50 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/8083:LOC102237251 ^@ http://purl.uniprot.org/uniprot/A0A3B5R8K7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/8083:agt ^@ http://purl.uniprot.org/uniprot/A0A3B5PSG8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family.|||Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.|||Secreted|||Stimulates aldosterone release. http://togogenome.org/gene/8083:guf1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QLY9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. LepA subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Mitochondrion inner membrane|||Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. http://togogenome.org/gene/8083:sema6b ^@ http://purl.uniprot.org/uniprot/M4AEZ3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102224372 ^@ http://purl.uniprot.org/uniprot/A0A3B5QNX2 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/8083:LOC102234594 ^@ http://purl.uniprot.org/uniprot/V5W8E9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins. http://togogenome.org/gene/8083:gnb3 ^@ http://purl.uniprot.org/uniprot/M4A9K6 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/8083:slc17a9 ^@ http://purl.uniprot.org/uniprot/M4AMJ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102222872 ^@ http://purl.uniprot.org/uniprot/M3ZMI3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.|||Nucleus|||Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. http://togogenome.org/gene/8083:rem1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R8W8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/8083:msx1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3L0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:gabrg1 ^@ http://purl.uniprot.org/uniprot/M4AM25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:pgr ^@ http://purl.uniprot.org/uniprot/M3ZZD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/8083:dedd2 ^@ http://purl.uniprot.org/uniprot/A0A3B5R8S6 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/8083:LOC102228095 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9G5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:gbx1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QG65 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:gng5 ^@ http://purl.uniprot.org/uniprot/M4AU70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/8083:tmlhe ^@ http://purl.uniprot.org/uniprot/M3ZRV1 ^@ Similarity ^@ Belongs to the gamma-BBH/TMLD family. http://togogenome.org/gene/8083:popdc3 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAG4 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/8083:LOC102230164 ^@ http://purl.uniprot.org/uniprot/M4A5Y8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||Vacuole membrane|||clathrin-coated vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/8083:LOC102219885 ^@ http://purl.uniprot.org/uniprot/A0A3B5R030 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX16 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102216615 ^@ http://purl.uniprot.org/uniprot/M4AWJ2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:LOC102235695 ^@ http://purl.uniprot.org/uniprot/A0A3B5QXA5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102224189 ^@ http://purl.uniprot.org/uniprot/M3ZMT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.|||Endomembrane system http://togogenome.org/gene/8083:ormdl2 ^@ http://purl.uniprot.org/uniprot/M4AB54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/8083:c9 ^@ http://purl.uniprot.org/uniprot/M3ZSX4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:LOC102219803 ^@ http://purl.uniprot.org/uniprot/M3ZLB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/8083:cck ^@ http://purl.uniprot.org/uniprot/M3ZDU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Secreted http://togogenome.org/gene/8083:LOC102221468 ^@ http://purl.uniprot.org/uniprot/M4AN22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102230635 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q4U4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C2 family.|||Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.|||Secreted http://togogenome.org/gene/8083:LOC102229065 ^@ http://purl.uniprot.org/uniprot/M3ZQE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/8083:eny2 ^@ http://purl.uniprot.org/uniprot/M3ZY04 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2). Component of the SAGA transcription coactivator-HAT complex. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.|||nucleoplasm http://togogenome.org/gene/8083:LOC102222671 ^@ http://purl.uniprot.org/uniprot/M4AS46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCC3 family.|||Membrane|||Mitochondrion inner membrane|||Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology. http://togogenome.org/gene/8083:LOC102219152 ^@ http://purl.uniprot.org/uniprot/M3ZN35 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102218195 ^@ http://purl.uniprot.org/uniprot/M4AV92 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/8083:LOC102237347 ^@ http://purl.uniprot.org/uniprot/M4AL74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/8083:LOC102226062 ^@ http://purl.uniprot.org/uniprot/A0A3B5QSD7 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/8083:LOC102223297 ^@ http://purl.uniprot.org/uniprot/M4AF41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/8083:LOC102237980 ^@ http://purl.uniprot.org/uniprot/A0A3B5QSR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/8083:LOC102229821 ^@ http://purl.uniprot.org/uniprot/M4AKE8 ^@ Similarity ^@ Belongs to the peptidase M17 family. http://togogenome.org/gene/8083:rab4a ^@ http://purl.uniprot.org/uniprot/A0A3B5QSS9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. http://togogenome.org/gene/8083:lamtor4 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q5G9 ^@ Similarity ^@ Belongs to the LAMTOR4 family. http://togogenome.org/gene/8083:ppp4c ^@ http://purl.uniprot.org/uniprot/M3ZJX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102236796 ^@ http://purl.uniprot.org/uniprot/M4AFL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/8083:trpt1 ^@ http://purl.uniprot.org/uniprot/M3ZLQ3 ^@ Function|||Similarity ^@ Belongs to the KptA/TPT1 family.|||Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate. http://togogenome.org/gene/8083:LOC106699827 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q883 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:LOC102232030 ^@ http://purl.uniprot.org/uniprot/M3ZKT3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/8083:e2f2 ^@ http://purl.uniprot.org/uniprot/M4ADP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/8083:kras ^@ http://purl.uniprot.org/uniprot/A0A3B5R4F4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/8083:nsrp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QFH6 ^@ Similarity ^@ Belongs to the NSRP1 family. http://togogenome.org/gene/8083:mpped2 ^@ http://purl.uniprot.org/uniprot/M4A764 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/8083:LOC102234682 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQW8 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/8083:hgh1 ^@ http://purl.uniprot.org/uniprot/M3ZDM3 ^@ Similarity ^@ Belongs to the HGH1 family. http://togogenome.org/gene/8083:cgas ^@ http://purl.uniprot.org/uniprot/A0A3B5QFW1 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/8083:LOC102230099 ^@ http://purl.uniprot.org/uniprot/M3ZSS2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102229529 ^@ http://purl.uniprot.org/uniprot/M4AV19 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/8083:LOC102233756 ^@ http://purl.uniprot.org/uniprot/M4AC17 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:kcnb1 ^@ http://purl.uniprot.org/uniprot/M3ZGL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.|||Lateral cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synaptic cell membrane|||axon|||dendrite|||sarcolemma|||synaptosome http://togogenome.org/gene/8083:pcna ^@ http://purl.uniprot.org/uniprot/M4AKD0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PCNA family.|||Nucleus|||This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. http://togogenome.org/gene/8083:ing1 ^@ http://purl.uniprot.org/uniprot/M4ACG4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/8083:LOC102230689 ^@ http://purl.uniprot.org/uniprot/A0A3B5R827 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/8083:LOC102233218 ^@ http://purl.uniprot.org/uniprot/A0A3B5QV20 ^@ Similarity ^@ Belongs to the RRM TRSPAP family. http://togogenome.org/gene/8083:LOC102224204 ^@ http://purl.uniprot.org/uniprot/M4A723 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/8083:LOC102238342 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPF1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102231647 ^@ http://purl.uniprot.org/uniprot/M4ADF6 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/8083:coro2a ^@ http://purl.uniprot.org/uniprot/M4A6J6 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/8083:LOC102218729 ^@ http://purl.uniprot.org/uniprot/M4AGZ2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/8083:LOC102232995 ^@ http://purl.uniprot.org/uniprot/M4AB77 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/8083:ren ^@ http://purl.uniprot.org/uniprot/M4ARK5 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/8083:atxn7l3 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0G0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SGF11 family.|||Component of some SAGA transcription coactivator-HAT complexes. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).|||Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.|||Nucleus|||The C-terminal SGF11-type zinc-finger domain forms part of the 'catalytic lobe' of the SAGA deubiquitination module.|||The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module. http://togogenome.org/gene/8083:b4gat1 ^@ http://purl.uniprot.org/uniprot/M4AJS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 49 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:tm4sf4 ^@ http://purl.uniprot.org/uniprot/M3ZE98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/8083:isoc2 ^@ http://purl.uniprot.org/uniprot/M4ABV9 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/8083:LOC102236432 ^@ http://purl.uniprot.org/uniprot/A0A3B5R2T7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane http://togogenome.org/gene/8083:nr0b2 ^@ http://purl.uniprot.org/uniprot/M4A7X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102237280 ^@ http://purl.uniprot.org/uniprot/M4AHP8 ^@ Similarity ^@ Belongs to the IER family. http://togogenome.org/gene/8083:dnajb12 ^@ http://purl.uniprot.org/uniprot/M4AKK5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:itpka ^@ http://purl.uniprot.org/uniprot/A0A3B5PXV7 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/8083:sumf2 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8S4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase-modifying factor family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/8083:LOC102236061 ^@ http://purl.uniprot.org/uniprot/A0A3B5R5H7 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/8083:LOC102217358 ^@ http://purl.uniprot.org/uniprot/A0A3B5QIH7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:cc2d1a ^@ http://purl.uniprot.org/uniprot/M4AEP7 ^@ Similarity ^@ Belongs to the CC2D1 family. http://togogenome.org/gene/8083:LOC102227159 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/8083:map3k15 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7Z0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/8083:erg28 ^@ http://purl.uniprot.org/uniprot/M4AK02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG28 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:sike1 ^@ http://purl.uniprot.org/uniprot/M3ZFB0 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/8083:atp6v1d ^@ http://purl.uniprot.org/uniprot/A0A3B5RAF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase D subunit family.|||clathrin-coated vesicle membrane http://togogenome.org/gene/8083:fam114a2 ^@ http://purl.uniprot.org/uniprot/M4AM43 ^@ Similarity ^@ Belongs to the FAM114 family. http://togogenome.org/gene/8083:LOC102223585 ^@ http://purl.uniprot.org/uniprot/A0A3B5R688 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 31 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102232628 ^@ http://purl.uniprot.org/uniprot/A0A3B5R297 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/8083:LOC102233854 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPX7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:cenpm ^@ http://purl.uniprot.org/uniprot/M3ZXG4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:rock2 ^@ http://purl.uniprot.org/uniprot/M4A449 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by RHOA binding. Inhibited by Y-27632.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cytoplasm|||Homodimer.|||Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. http://togogenome.org/gene/8083:tet1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWJ1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TET family.|||Binds 1 Fe(2+) ion per subunit.|||Chromosome|||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.|||The zinc ions have a structural role. http://togogenome.org/gene/8083:LOC102230901 ^@ http://purl.uniprot.org/uniprot/M3ZIG6 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/8083:usp13 ^@ http://purl.uniprot.org/uniprot/M4AV40 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/8083:LOC102226286 ^@ http://purl.uniprot.org/uniprot/M3ZL64 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/8083:tbx3 ^@ http://purl.uniprot.org/uniprot/M3ZT55 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/8083:ctnnb1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R3Z5 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/8083:LOC102218227 ^@ http://purl.uniprot.org/uniprot/M3ZZI1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/8083:LOC102235410 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q277 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/8083:c12h12orf43 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q552 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUSTOS family.|||Nucleus envelope http://togogenome.org/gene/8083:dck ^@ http://purl.uniprot.org/uniprot/M3ZT88 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/8083:LOC102220874 ^@ http://purl.uniprot.org/uniprot/M4A1R2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102220115 ^@ http://purl.uniprot.org/uniprot/A0A3B5PSS4 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/8083:LOC102227785 ^@ http://purl.uniprot.org/uniprot/M3ZP96 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:LOC102217936 ^@ http://purl.uniprot.org/uniprot/M4ADL4 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/8083:gpr137b ^@ http://purl.uniprot.org/uniprot/M3ZWZ1 ^@ Subcellular Location Annotation ^@ Lysosome membrane|||Membrane http://togogenome.org/gene/8083:acad9 ^@ http://purl.uniprot.org/uniprot/M3ZZ62 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/8083:pym1 ^@ http://purl.uniprot.org/uniprot/M4AB25 ^@ Similarity|||Subunit ^@ Belongs to the pym family.|||Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex. http://togogenome.org/gene/8083:fam8a1 ^@ http://purl.uniprot.org/uniprot/M3ZN30 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:meaf6 ^@ http://purl.uniprot.org/uniprot/M3ZMU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EAF6 family.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.|||Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.|||kinetochore|||nucleolus http://togogenome.org/gene/8083:map3k13 ^@ http://purl.uniprot.org/uniprot/M4AMN8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/8083:mrpl47 ^@ http://purl.uniprot.org/uniprot/M4AUZ4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/8083:l3hypdh ^@ http://purl.uniprot.org/uniprot/M3ZNS5 ^@ Similarity ^@ Belongs to the proline racemase family. http://togogenome.org/gene/8083:serpinf1 ^@ http://purl.uniprot.org/uniprot/M3ZXG0 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8083:LOC102224775 ^@ http://purl.uniprot.org/uniprot/M4A2G6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM237 family.|||Component of the transition zone in primary cilia. Required for ciliogenesis.|||Membrane|||cilium http://togogenome.org/gene/8083:LOC102231912 ^@ http://purl.uniprot.org/uniprot/M4AST5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:LOC102232348 ^@ http://purl.uniprot.org/uniprot/A0A3B5PV22 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/8083:LOC102229187 ^@ http://purl.uniprot.org/uniprot/M3ZZ87 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fibulin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/8083:fermt3 ^@ http://purl.uniprot.org/uniprot/M3ZLQ0 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/8083:LOC102233918 ^@ http://purl.uniprot.org/uniprot/M4AXN2 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/8083:sar1b ^@ http://purl.uniprot.org/uniprot/M4A1H1 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/8083:capn7 ^@ http://purl.uniprot.org/uniprot/M4AS68 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/8083:pik3cg ^@ http://purl.uniprot.org/uniprot/M4A2Z1 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/8083:zdhhc15 ^@ http://purl.uniprot.org/uniprot/M4A3S5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/8083:LOC102227162 ^@ http://purl.uniprot.org/uniprot/M3ZFP2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/8083:LOC102236374 ^@ http://purl.uniprot.org/uniprot/M4B0X7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:jag1 ^@ http://purl.uniprot.org/uniprot/M3ZVZ9 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/8083:LOC102218062 ^@ http://purl.uniprot.org/uniprot/M3ZIT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/8083:LOC102232638 ^@ http://purl.uniprot.org/uniprot/M3ZUI5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102219251 ^@ http://purl.uniprot.org/uniprot/M4AJL1 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. http://togogenome.org/gene/8083:best2 ^@ http://purl.uniprot.org/uniprot/M3ZSU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms chloride channels.|||Membrane http://togogenome.org/gene/8083:LOC102227857 ^@ http://purl.uniprot.org/uniprot/M3ZVZ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102235431 ^@ http://purl.uniprot.org/uniprot/M4AWK9 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/8083:LOC102223640 ^@ http://purl.uniprot.org/uniprot/A0A3B5QBQ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/8083:tsen54 ^@ http://purl.uniprot.org/uniprot/M4AWL0 ^@ Similarity ^@ Belongs to the SEN54 family. http://togogenome.org/gene/8083:ccnb3 ^@ http://purl.uniprot.org/uniprot/M4AKU5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. http://togogenome.org/gene/8083:inpp1 ^@ http://purl.uniprot.org/uniprot/M3ZN14 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/8083:pgls ^@ http://purl.uniprot.org/uniprot/M4AFR6 ^@ Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.|||Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. http://togogenome.org/gene/8083:polr2c ^@ http://purl.uniprot.org/uniprot/M4ANH7 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/8083:abcd1 ^@ http://purl.uniprot.org/uniprot/M3ZMP3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:fam49a ^@ http://purl.uniprot.org/uniprot/M4A8J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYRI family.|||Membrane http://togogenome.org/gene/8083:st3gal4 ^@ http://purl.uniprot.org/uniprot/A0A3B5REZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8083:LOC102238422 ^@ http://purl.uniprot.org/uniprot/A0A3B5QTT7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/8083:clptm1l ^@ http://purl.uniprot.org/uniprot/M4AM86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLPTM1 family.|||Membrane http://togogenome.org/gene/8083:LOC102229498 ^@ http://purl.uniprot.org/uniprot/M3ZP70 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:xylt2 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1Y6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 14 family. XylT subfamily.|||Golgi apparatus membrane|||Membrane|||Monomer. http://togogenome.org/gene/8083:emc8 ^@ http://purl.uniprot.org/uniprot/M3ZLM8 ^@ Similarity ^@ Belongs to the EMC8/EMC9 family. http://togogenome.org/gene/8083:LOC102231304 ^@ http://purl.uniprot.org/uniprot/A0A3B5QU88 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102218672 ^@ http://purl.uniprot.org/uniprot/M4ANG1 ^@ Similarity|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer. http://togogenome.org/gene/8083:mterf3 ^@ http://purl.uniprot.org/uniprot/M3ZMM4 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/8083:LOC102234613 ^@ http://purl.uniprot.org/uniprot/A0A3B5R621 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.|||Membrane http://togogenome.org/gene/8083:mfsd14a ^@ http://purl.uniprot.org/uniprot/M3ZEE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/8083:lypla2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPC6 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/8083:LOC102236420 ^@ http://purl.uniprot.org/uniprot/M4ADN5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102222790 ^@ http://purl.uniprot.org/uniprot/M4A1W9 ^@ Similarity ^@ Belongs to the YY transcription factor family. http://togogenome.org/gene/8083:cnksr2 ^@ http://purl.uniprot.org/uniprot/M3ZN83 ^@ Similarity ^@ Belongs to the CNKSR family. http://togogenome.org/gene/8083:lgr6 ^@ http://purl.uniprot.org/uniprot/A0A3B5PQZ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102235443 ^@ http://purl.uniprot.org/uniprot/M3ZXI3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.|||Mitochondrion http://togogenome.org/gene/8083:LOC102235150 ^@ http://purl.uniprot.org/uniprot/M4AVB9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/8083:lsm12 ^@ http://purl.uniprot.org/uniprot/A0A3B5QM91 ^@ Similarity ^@ Belongs to the LSM12 family. http://togogenome.org/gene/8083:mrpl16 ^@ http://purl.uniprot.org/uniprot/M4AXN5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/8083:LOC102222054 ^@ http://purl.uniprot.org/uniprot/M4AIG5 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/8083:ankrd13b ^@ http://purl.uniprot.org/uniprot/A0A3B5Q174 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/8083:LOC102236735 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/8083:kat8 ^@ http://purl.uniprot.org/uniprot/M3ZHU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/8083:fabp1 ^@ http://purl.uniprot.org/uniprot/M4ANR5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.|||Cytoplasm|||Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. http://togogenome.org/gene/8083:LOC102228636 ^@ http://purl.uniprot.org/uniprot/A0A3B5PZH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/8083:LOC102233603 ^@ http://purl.uniprot.org/uniprot/M3ZYA3 ^@ Similarity ^@ Belongs to the caprin family. http://togogenome.org/gene/8083:LOC102228520 ^@ http://purl.uniprot.org/uniprot/M4A420 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/8083:ddx56 ^@ http://purl.uniprot.org/uniprot/M4AWF4 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/8083:enkur ^@ http://purl.uniprot.org/uniprot/A0A3B5QK07 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/8083:mysm1 ^@ http://purl.uniprot.org/uniprot/M4A9T8 ^@ Similarity ^@ Belongs to the peptidase M67A family. MYSM1 subfamily. http://togogenome.org/gene/8083:b3gat3 ^@ http://purl.uniprot.org/uniprot/M4ARJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:LOC102236423 ^@ http://purl.uniprot.org/uniprot/M4AR58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Endosome|||Membrane|||Membrane raft|||Recycling endosome|||trans-Golgi network http://togogenome.org/gene/8083:prpf4b ^@ http://purl.uniprot.org/uniprot/M3ZHT1 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.|||Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF. http://togogenome.org/gene/8083:LOC102224538 ^@ http://purl.uniprot.org/uniprot/M4AJE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/8083:lamtor5 ^@ http://purl.uniprot.org/uniprot/A0A3B5QX46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR5 family.|||Lysosome http://togogenome.org/gene/8083:LOC102223670 ^@ http://purl.uniprot.org/uniprot/M4A3M3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/8083:rpl13 ^@ http://purl.uniprot.org/uniprot/M3ZLY7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/8083:alg8 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:lgi1 ^@ http://purl.uniprot.org/uniprot/M4A0H6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/8083:fam45a ^@ http://purl.uniprot.org/uniprot/M4A0J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND10 family.|||Endosome|||Late endosome http://togogenome.org/gene/8083:LOC102237032 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9V9 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/8083:mdm4 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Nucleus http://togogenome.org/gene/8083:LOC102219400 ^@ http://purl.uniprot.org/uniprot/A0A3B5PXK4 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/8083:LOC102216917 ^@ http://purl.uniprot.org/uniprot/M4ALN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/8083:hsd17b4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QBU2 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/8083:hdac2 ^@ http://purl.uniprot.org/uniprot/M4AX43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/8083:snw1 ^@ http://purl.uniprot.org/uniprot/M4A921 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNW family.|||Identified in the spliceosome C complex.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/8083:LOC102222315 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZS9 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/8083:dpp7 ^@ http://purl.uniprot.org/uniprot/M3ZPV5 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/8083:kif5a ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0C7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/8083:tbcb ^@ http://purl.uniprot.org/uniprot/M3ZQ26 ^@ Similarity ^@ Belongs to the TBCB family. http://togogenome.org/gene/8083:LOC102234220 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZY2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SH3BP5 family.|||Cytoplasm|||Functions as guanine nucleotide exchange factor (GEF) for RAB11A.|||Interacts with GDP-bound and nucleotide-free forms of RAB11A.|||The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape. http://togogenome.org/gene/8083:c1h20orf24 ^@ http://purl.uniprot.org/uniprot/A0A3B5QYZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102231702 ^@ http://purl.uniprot.org/uniprot/M3ZUD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:LOC102223762 ^@ http://purl.uniprot.org/uniprot/M3ZQ01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/8083:hdac8 ^@ http://purl.uniprot.org/uniprot/M4AK88 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones.|||Nucleus http://togogenome.org/gene/8083:acot8 ^@ http://purl.uniprot.org/uniprot/M4A4Y1 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/8083:LOC102237787 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q5T5 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/8083:cnot8 ^@ http://purl.uniprot.org/uniprot/M4AM64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/8083:LOC102237636 ^@ http://purl.uniprot.org/uniprot/M4A1B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/8083:per3 ^@ http://purl.uniprot.org/uniprot/M3ZP67 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/8083:ccno ^@ http://purl.uniprot.org/uniprot/M3ZKM5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. http://togogenome.org/gene/8083:LOC102231744 ^@ http://purl.uniprot.org/uniprot/M4AV22 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102223915 ^@ http://purl.uniprot.org/uniprot/M3ZMC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/8083:LOC102230695 ^@ http://purl.uniprot.org/uniprot/A0A3B5QYV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/8083:LOC102230784 ^@ http://purl.uniprot.org/uniprot/M4AM52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:LOC102221735 ^@ http://purl.uniprot.org/uniprot/M4AU94 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||synaptic vesicle membrane http://togogenome.org/gene/8083:cdc123 ^@ http://purl.uniprot.org/uniprot/M4A2I9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC123 family.|||Cytoplasm|||Required for S phase entry of the cell cycle. http://togogenome.org/gene/8083:LOC102222773 ^@ http://purl.uniprot.org/uniprot/M4A571 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/8083:cap2 ^@ http://purl.uniprot.org/uniprot/M3ZMI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAP family.|||Cell membrane http://togogenome.org/gene/8083:LOC102219780 ^@ http://purl.uniprot.org/uniprot/A0A3B5R9J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/8083:upp2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QEW6 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. http://togogenome.org/gene/8083:cluh ^@ http://purl.uniprot.org/uniprot/A0A3B5QPD3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CLU family.|||Cytoplasm|||Cytoplasmic granule|||mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis. http://togogenome.org/gene/8083:LOC102236473 ^@ http://purl.uniprot.org/uniprot/M3ZXG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/8083:lyrm7 ^@ http://purl.uniprot.org/uniprot/M4AUR0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.|||Belongs to the complex I LYR family.|||Interacts with UQCRFS1.|||Mitochondrion matrix http://togogenome.org/gene/8083:pold1 ^@ http://purl.uniprot.org/uniprot/M4ABE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||Nucleus http://togogenome.org/gene/8083:LOC102236545 ^@ http://purl.uniprot.org/uniprot/A0A3B5RFF2 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:wisp1 ^@ http://purl.uniprot.org/uniprot/M3ZKF6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:snx17 ^@ http://purl.uniprot.org/uniprot/M3ZPR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/8083:LOC102217443 ^@ http://purl.uniprot.org/uniprot/A0A3B5R114 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/8083:wnt10b ^@ http://purl.uniprot.org/uniprot/M4A9Q4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/8083:dtwd2 ^@ http://purl.uniprot.org/uniprot/M4AW94 ^@ Similarity ^@ Belongs to the TDD superfamily. DTWD2 family. http://togogenome.org/gene/8083:acsl5 ^@ http://purl.uniprot.org/uniprot/M4ATM1 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. http://togogenome.org/gene/8083:LOC102237426 ^@ http://purl.uniprot.org/uniprot/M4AXK5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102227505 ^@ http://purl.uniprot.org/uniprot/M4AWB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102220406 ^@ http://purl.uniprot.org/uniprot/A0A3B5PTT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/8083:LOC102223974 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZ78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/8083:LOC102224841 ^@ http://purl.uniprot.org/uniprot/M3ZL98 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:aacs ^@ http://purl.uniprot.org/uniprot/M3ZLB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Converts acetoacetate to acetoacetyl-CoA in the cytosol.|||cytosol http://togogenome.org/gene/8083:LOC102236581 ^@ http://purl.uniprot.org/uniprot/M3ZFN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/8083:LOC102221347 ^@ http://purl.uniprot.org/uniprot/M4ASJ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102234173 ^@ http://purl.uniprot.org/uniprot/M3ZM84 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOTCH family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Nucleus http://togogenome.org/gene/8083:nup93 ^@ http://purl.uniprot.org/uniprot/A0A3B5PYA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin interacting component (NIC) family.|||Nucleus membrane|||Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.|||nuclear pore complex http://togogenome.org/gene/8083:LOC102222878 ^@ http://purl.uniprot.org/uniprot/M3ZJH8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:alg2 ^@ http://purl.uniprot.org/uniprot/M4AFI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.|||Membrane http://togogenome.org/gene/8083:LOC102230699 ^@ http://purl.uniprot.org/uniprot/M4A1W8 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/8083:LOC102216404 ^@ http://purl.uniprot.org/uniprot/M4AG42 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8083:slc26a11 ^@ http://purl.uniprot.org/uniprot/M4AEQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/8083:LOC102218710 ^@ http://purl.uniprot.org/uniprot/M3ZLM4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Membrane|||Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity. http://togogenome.org/gene/8083:slc25a44 ^@ http://purl.uniprot.org/uniprot/M3ZCT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:slu7 ^@ http://purl.uniprot.org/uniprot/M4A3L8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SLU7 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/8083:LOC102222819 ^@ http://purl.uniprot.org/uniprot/M3ZZ30 ^@ Function|||Similarity ^@ Belongs to the troponin T family.|||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/8083:LOC102220683 ^@ http://purl.uniprot.org/uniprot/M4A857 ^@ Similarity ^@ Belongs to the p23/wos2 family. http://togogenome.org/gene/8083:LOC102227535 ^@ http://purl.uniprot.org/uniprot/A0A3B5QBU0 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:mrpl10 ^@ http://purl.uniprot.org/uniprot/M4AGY1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL10 family. http://togogenome.org/gene/8083:nmd3 ^@ http://purl.uniprot.org/uniprot/M4AVI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.|||Belongs to the NMD3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102233739 ^@ http://purl.uniprot.org/uniprot/M4AX69 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/8083:vegfa ^@ http://purl.uniprot.org/uniprot/A0A3B5QPP3 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/8083:psmc2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QH03 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/8083:bbs5 ^@ http://purl.uniprot.org/uniprot/A0A3B5PTF1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BBS5 family.|||Membrane|||Required for ciliogenesis.|||centriolar satellite|||cilium membrane http://togogenome.org/gene/8083:atxn1l ^@ http://purl.uniprot.org/uniprot/A0A3B5RES1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATXN1 family.|||Nucleus http://togogenome.org/gene/8083:LOC102217608 ^@ http://purl.uniprot.org/uniprot/A0A3B5R2P5 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/8083:mrps30 ^@ http://purl.uniprot.org/uniprot/M3ZLP1 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/8083:chst2 ^@ http://purl.uniprot.org/uniprot/M4B058 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/8083:ddx55 ^@ http://purl.uniprot.org/uniprot/M4ABE5 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/8083:med30 ^@ http://purl.uniprot.org/uniprot/M4AHW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 30 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/8083:carnmt1 ^@ http://purl.uniprot.org/uniprot/M4AM51 ^@ Similarity ^@ Belongs to the carnosine N-methyltransferase family. http://togogenome.org/gene/8083:apex1 ^@ http://purl.uniprot.org/uniprot/M3ZVG8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/8083:LOC102222801 ^@ http://purl.uniprot.org/uniprot/M4ABK3 ^@ Similarity ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. http://togogenome.org/gene/8083:LOC102224238 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q2D3 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/8083:LOC102220041 ^@ http://purl.uniprot.org/uniprot/M4A9K1 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||desmosome http://togogenome.org/gene/8083:LOC102229002 ^@ http://purl.uniprot.org/uniprot/M3ZU54 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.|||Preautophagosomal structure membrane http://togogenome.org/gene/8083:c12h12orf49 ^@ http://purl.uniprot.org/uniprot/A0A3B5PSK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPRING family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:washc3 ^@ http://purl.uniprot.org/uniprot/M3ZGV9 ^@ Similarity ^@ Belongs to the CCDC53 family. http://togogenome.org/gene/8083:mrpl18 ^@ http://purl.uniprot.org/uniprot/A0A3B5R636 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL18 family. http://togogenome.org/gene/8083:LOC102217982 ^@ http://purl.uniprot.org/uniprot/M4AS63 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family. http://togogenome.org/gene/8083:chst12 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q366 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:mpv17 ^@ http://purl.uniprot.org/uniprot/M3ZT28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/8083:LOC102217255 ^@ http://purl.uniprot.org/uniprot/M3ZLE3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102231377 ^@ http://purl.uniprot.org/uniprot/M4AUM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/8083:LOC102217018 ^@ http://purl.uniprot.org/uniprot/A0A3B5PSF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/8083:dusp3 ^@ http://purl.uniprot.org/uniprot/M4ATY5 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of AMPK and MAPK1/2 signaling pathways.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/8083:nsmce2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PTN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NSE2 family.|||Nucleus http://togogenome.org/gene/8083:LOC102232063 ^@ http://purl.uniprot.org/uniprot/M3ZKS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:smpdl3a ^@ http://purl.uniprot.org/uniprot/M3ZSW9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) per subunit.|||Secreted http://togogenome.org/gene/8083:LOC102224154 ^@ http://purl.uniprot.org/uniprot/M3ZRR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/8083:nudt6 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7K2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family.|||Cytoplasm|||May contribute to the regulation of cell proliferation.|||Mitochondrion|||Monomer and homodimer.|||Nucleus http://togogenome.org/gene/8083:LOC102219175 ^@ http://purl.uniprot.org/uniprot/M4AEI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/8083:phc1 ^@ http://purl.uniprot.org/uniprot/M4AB12 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102233813 ^@ http://purl.uniprot.org/uniprot/M4AZU1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the noggin family.|||Homodimer.|||Secreted http://togogenome.org/gene/8083:LOC102229930 ^@ http://purl.uniprot.org/uniprot/M4A957 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/8083:LOC102228766 ^@ http://purl.uniprot.org/uniprot/A0A3B5PS35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/8083:polr2i ^@ http://purl.uniprot.org/uniprot/A0A3B5R6F0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/8083:LOC102229835 ^@ http://purl.uniprot.org/uniprot/M4A462 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/8083:ttc39b ^@ http://purl.uniprot.org/uniprot/M3ZED9 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/8083:pptc7 ^@ http://purl.uniprot.org/uniprot/A0A3B5R8J0 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/8083:LOC102235400 ^@ http://purl.uniprot.org/uniprot/M4A675 ^@ Similarity ^@ Belongs to the GST superfamily. Mu family. http://togogenome.org/gene/8083:eif3k ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0H0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit K family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:dpcd ^@ http://purl.uniprot.org/uniprot/M3ZD05 ^@ Similarity ^@ Belongs to the DPCD family. http://togogenome.org/gene/8083:oat ^@ http://purl.uniprot.org/uniprot/M4AQ51 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/8083:tmco1 ^@ http://purl.uniprot.org/uniprot/M3ZVS9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMCO1 family.|||Calcium-selective channel required to prevent calcium stores from overfilling.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102236733 ^@ http://purl.uniprot.org/uniprot/M3ZVC8 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/8083:LOC102219972 ^@ http://purl.uniprot.org/uniprot/A0A3B5QIR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/8083:LOC102228142 ^@ http://purl.uniprot.org/uniprot/M3ZM46 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:LOC102219775 ^@ http://purl.uniprot.org/uniprot/M4AMP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102227734 ^@ http://purl.uniprot.org/uniprot/A0A3B5QY42 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/8083:ccne1 ^@ http://purl.uniprot.org/uniprot/M3ZFL7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. http://togogenome.org/gene/8083:LOC102220456 ^@ http://purl.uniprot.org/uniprot/M4AM56 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/8083:foxf1 ^@ http://purl.uniprot.org/uniprot/M3ZLJ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102238329 ^@ http://purl.uniprot.org/uniprot/M3ZN56 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/8083:mfn1 ^@ http://purl.uniprot.org/uniprot/M4AUU3 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/8083:cmc4 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDS8 ^@ Similarity ^@ Belongs to the CMC4 family. http://togogenome.org/gene/8083:ap4s1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R638 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/8083:hrh3 ^@ http://purl.uniprot.org/uniprot/A0A3B5PSS6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:c10h16orf91 ^@ http://purl.uniprot.org/uniprot/A0A3B5PU07 ^@ Similarity ^@ Belongs to the UQCC4 family. http://togogenome.org/gene/8083:dnm3 ^@ http://purl.uniprot.org/uniprot/M4AA09 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/8083:chac1 ^@ http://purl.uniprot.org/uniprot/M3ZPX5 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/8083:fermt1 ^@ http://purl.uniprot.org/uniprot/M4A2A8 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/8083:bola3 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q491 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/8083:LOC102232375 ^@ http://purl.uniprot.org/uniprot/M3ZUH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SMU1 family.|||Nucleus speckle http://togogenome.org/gene/8083:LOC102222046 ^@ http://purl.uniprot.org/uniprot/A0A3B5R2F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the extended synaptotagmin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102217555 ^@ http://purl.uniprot.org/uniprot/M3ZJL7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:stard3nl ^@ http://purl.uniprot.org/uniprot/M3ZN61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Membrane http://togogenome.org/gene/8083:rad21 ^@ http://purl.uniprot.org/uniprot/M4A2B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/8083:LOC102236527 ^@ http://purl.uniprot.org/uniprot/M3ZXA2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:pabpc1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QS12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/8083:slc49a3 ^@ http://purl.uniprot.org/uniprot/M4AUZ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:trmu ^@ http://purl.uniprot.org/uniprot/M3ZWY2 ^@ Function|||Similarity ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. http://togogenome.org/gene/8083:LOC102228409 ^@ http://purl.uniprot.org/uniprot/A0A3B5PSS2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.|||Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/8083:zw10 ^@ http://purl.uniprot.org/uniprot/M4AG76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZW10 family.|||kinetochore http://togogenome.org/gene/8083:LOC102229423 ^@ http://purl.uniprot.org/uniprot/M4A922 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/8083:gtpbp8 ^@ http://purl.uniprot.org/uniprot/M3ZQF0 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. http://togogenome.org/gene/8083:rars2 ^@ http://purl.uniprot.org/uniprot/M4AR88 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/8083:pfdn4 ^@ http://purl.uniprot.org/uniprot/M4AE06 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/8083:stxbp5l ^@ http://purl.uniprot.org/uniprot/A0A3B5PU63|||http://purl.uniprot.org/uniprot/A0A3B5RD46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/8083:LOC102229151 ^@ http://purl.uniprot.org/uniprot/M4AG81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/8083:LOC102223173 ^@ http://purl.uniprot.org/uniprot/M4AKP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/8083:kdelc1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QMG0 ^@ Similarity ^@ Belongs to the KDELC family. http://togogenome.org/gene/8083:fgfr1op2 ^@ http://purl.uniprot.org/uniprot/M4A3C5 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/8083:capza2 ^@ http://purl.uniprot.org/uniprot/M4AJ63 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/8083:LOC102227849 ^@ http://purl.uniprot.org/uniprot/M3ZHV6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:LOC102236460 ^@ http://purl.uniprot.org/uniprot/A0A3B5R2N3 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/8083:LOC102230390 ^@ http://purl.uniprot.org/uniprot/M4AN74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102234554 ^@ http://purl.uniprot.org/uniprot/A0A3B5PXB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the milton family.|||Early endosome|||Mitochondrion http://togogenome.org/gene/8083:LOC102223598 ^@ http://purl.uniprot.org/uniprot/M3ZL13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/8083:ncapd3 ^@ http://purl.uniprot.org/uniprot/M3ZU37 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the condensin-2 complex.|||Nucleus|||Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. http://togogenome.org/gene/8083:tacr2 ^@ http://purl.uniprot.org/uniprot/M4AJT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102233249 ^@ http://purl.uniprot.org/uniprot/M4AAG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:ern1 ^@ http://purl.uniprot.org/uniprot/M3ZGJ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:nmbr ^@ http://purl.uniprot.org/uniprot/A0A3B5R9I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:leprot ^@ http://purl.uniprot.org/uniprot/A0A3B5RBL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/8083:LOC102217076 ^@ http://purl.uniprot.org/uniprot/M4AXB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:pola1 ^@ http://purl.uniprot.org/uniprot/M4AXC6 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/8083:lbx1 ^@ http://purl.uniprot.org/uniprot/M4ADF8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:rftn2 ^@ http://purl.uniprot.org/uniprot/M3ZYY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102235393 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:draxin ^@ http://purl.uniprot.org/uniprot/M3ZVK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the draxin family.|||Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord.|||Secreted http://togogenome.org/gene/8083:slc16a9 ^@ http://purl.uniprot.org/uniprot/M3ZYT3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:csnk1e ^@ http://purl.uniprot.org/uniprot/A0A3B5R3N8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:LOC102229166 ^@ http://purl.uniprot.org/uniprot/M4A913 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/8083:marco ^@ http://purl.uniprot.org/uniprot/A0A3B5QPD7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:naa10 ^@ http://purl.uniprot.org/uniprot/M4AQT0 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/8083:c20h6orf89 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1K7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:fgfbp3 ^@ http://purl.uniprot.org/uniprot/M3ZRQ5 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/8083:rps18 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q716 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/8083:ippk ^@ http://purl.uniprot.org/uniprot/M3ZRG8 ^@ Domain|||Function|||Similarity ^@ Belongs to the IPK1 type 2 family.|||Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).|||The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2. http://togogenome.org/gene/8083:LOC102226068 ^@ http://purl.uniprot.org/uniprot/M4AIC3 ^@ Similarity ^@ Belongs to the WAPL family. http://togogenome.org/gene/8083:pik3c3 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9A0 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/8083:tshr ^@ http://purl.uniprot.org/uniprot/M3ZHD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||Lateral cell membrane|||Membrane|||Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. http://togogenome.org/gene/8083:cldn11 ^@ http://purl.uniprot.org/uniprot/A0A3B5PYT6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/8083:LOC102217447 ^@ http://purl.uniprot.org/uniprot/M4AQ99 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:LOC102238026 ^@ http://purl.uniprot.org/uniprot/M3ZYI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/8083:ing2 ^@ http://purl.uniprot.org/uniprot/M3ZZT7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/8083:LOC102233045 ^@ http://purl.uniprot.org/uniprot/M4AKR9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:tspan18 ^@ http://purl.uniprot.org/uniprot/A0A3B5QTD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:LOC102219637 ^@ http://purl.uniprot.org/uniprot/M4AGA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/8083:LOC102226609 ^@ http://purl.uniprot.org/uniprot/A0A3B5PRC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/8083:cwc25 ^@ http://purl.uniprot.org/uniprot/M4AUK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CWC25 family.|||Nucleus http://togogenome.org/gene/8083:ugt8 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHT3 ^@ Similarity ^@ Belongs to the UDP-glycosyltransferase family. http://togogenome.org/gene/8083:LOC102234678 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q6V2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:LOC102230010 ^@ http://purl.uniprot.org/uniprot/M3ZLD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.|||Endomembrane system|||Nucleus http://togogenome.org/gene/8083:LOC102231519 ^@ http://purl.uniprot.org/uniprot/M3ZES4 ^@ Similarity ^@ Belongs to the AccD/PCCB family. http://togogenome.org/gene/8083:skil ^@ http://purl.uniprot.org/uniprot/M3ZE34 ^@ Similarity ^@ Belongs to the SKI family. http://togogenome.org/gene/8083:LOC102233830 ^@ http://purl.uniprot.org/uniprot/M4A7J7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:LOC102218868 ^@ http://purl.uniprot.org/uniprot/M4ALY7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/8083:LOC102230910 ^@ http://purl.uniprot.org/uniprot/M3ZFD5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:LOC102227277 ^@ http://purl.uniprot.org/uniprot/A0A3B5R8P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:LOC102237320 ^@ http://purl.uniprot.org/uniprot/A0A3B5QJA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/8083:atg12 ^@ http://purl.uniprot.org/uniprot/M4ABW9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATG12 family.|||Forms a conjugate with ATG5.|||Ubiquitin-like protein involved in autophagic vesicle formation. http://togogenome.org/gene/8083:med20 ^@ http://purl.uniprot.org/uniprot/M3ZFS5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 20 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/8083:LOC102229500 ^@ http://purl.uniprot.org/uniprot/A0A3B5QMC5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POMC family.|||Endogenous opiate.|||Secreted|||Stimulates the adrenal glands to release cortisol. http://togogenome.org/gene/8083:LOC102234003 ^@ http://purl.uniprot.org/uniprot/M3ZS61 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:fam171a1 ^@ http://purl.uniprot.org/uniprot/M4AF26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM171 family.|||Membrane http://togogenome.org/gene/8083:gpr155 ^@ http://purl.uniprot.org/uniprot/M3ZT90 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102216436 ^@ http://purl.uniprot.org/uniprot/M4AHI1 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/8083:riok3 ^@ http://purl.uniprot.org/uniprot/M4AEP4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/8083:LOC102237619 ^@ http://purl.uniprot.org/uniprot/M3ZL03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:grm8 ^@ http://purl.uniprot.org/uniprot/M4A4Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102236181 ^@ http://purl.uniprot.org/uniprot/M3ZIS3 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family.|||Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. http://togogenome.org/gene/8083:lsm8 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q4D9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. http://togogenome.org/gene/8083:tcp11l2 ^@ http://purl.uniprot.org/uniprot/M4AVU8 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/8083:LOC102228733 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZA0 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/8083:LOC102238121 ^@ http://purl.uniprot.org/uniprot/M4B071 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/8083:tas1r2 ^@ http://purl.uniprot.org/uniprot/M4AWX9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102225994 ^@ http://purl.uniprot.org/uniprot/M4AQ47 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/8083:ino80d ^@ http://purl.uniprot.org/uniprot/A0A3B5R8D4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:gal ^@ http://purl.uniprot.org/uniprot/M4ANV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the galanin family.|||Secreted http://togogenome.org/gene/8083:LOC102220042 ^@ http://purl.uniprot.org/uniprot/M4A4W1 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/8083:kcnq4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QY99 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:ube4b ^@ http://purl.uniprot.org/uniprot/A0A3B5R0B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm http://togogenome.org/gene/8083:slc25a4 ^@ http://purl.uniprot.org/uniprot/M3ZTW2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/8083:uchl5 ^@ http://purl.uniprot.org/uniprot/M3ZKG2 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/8083:LOC102228446 ^@ http://purl.uniprot.org/uniprot/A0A3B5PQ75 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:usp5 ^@ http://purl.uniprot.org/uniprot/M4A9G3 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/8083:LOC102227132 ^@ http://purl.uniprot.org/uniprot/M4AQ97 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:rb1 ^@ http://purl.uniprot.org/uniprot/A3DUJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the retinoblastoma protein (RB) family.|||Nucleus http://togogenome.org/gene/8083:kcnh6 ^@ http://purl.uniprot.org/uniprot/M4A0V6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:lhx9 ^@ http://purl.uniprot.org/uniprot/A0A3B5PWN6|||http://purl.uniprot.org/uniprot/A0A3B5R0P2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102224048 ^@ http://purl.uniprot.org/uniprot/M3ZV14 ^@ Caution|||Similarity ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:hcfc1 ^@ http://purl.uniprot.org/uniprot/M4A542 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:snrpc ^@ http://purl.uniprot.org/uniprot/M4AU30 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U1 small nuclear ribonucleoprotein C family.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Nucleus|||U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. http://togogenome.org/gene/8083:rprd1a ^@ http://purl.uniprot.org/uniprot/M3ZLT8 ^@ Similarity ^@ Belongs to the UPF0400 (RTT103) family. http://togogenome.org/gene/8083:blcap ^@ http://purl.uniprot.org/uniprot/M4AYG5 ^@ Similarity ^@ Belongs to the BLCAP family. http://togogenome.org/gene/8083:tspan17 ^@ http://purl.uniprot.org/uniprot/M4A6R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:LOC102218202 ^@ http://purl.uniprot.org/uniprot/A0A3B5QYA5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/8083:imp4 ^@ http://purl.uniprot.org/uniprot/M3ZRU0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/8083:LOC102234009 ^@ http://purl.uniprot.org/uniprot/M3ZL62 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/8083:LOC102221860 ^@ http://purl.uniprot.org/uniprot/M4AUK1 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/8083:LOC102228440 ^@ http://purl.uniprot.org/uniprot/M3ZUU1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||basement membrane http://togogenome.org/gene/8083:kcnk6 ^@ http://purl.uniprot.org/uniprot/A0A3B5QK63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/8083:LOC102225027 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q224 ^@ Similarity ^@ Belongs to the PP1 inhibitor family. http://togogenome.org/gene/8083:LOC102229100 ^@ http://purl.uniprot.org/uniprot/A0A3B5R5R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WRB/GET1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102220667 ^@ http://purl.uniprot.org/uniprot/M4AJ20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:pcyt1b ^@ http://purl.uniprot.org/uniprot/A0A3B5PUN4 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/8083:LOC102233610 ^@ http://purl.uniprot.org/uniprot/M4A9N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM120 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/8083:dmrta2 ^@ http://purl.uniprot.org/uniprot/Q2I327 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the DMRT family.|||Expressed in brain and eye.|||From 3 dpc, expressed in the olfactory placode, forebrain, midbrain, and lenses. At later stages, expression in the lenses is no longer detectable but is found in the fore- and ventral mid-brain and in the mid-hind-brain boundary. At 5 dpc, expressed in olfactory epithelium and brain.|||May be involved in sexual development.|||Nucleus http://togogenome.org/gene/8083:tmem50b ^@ http://purl.uniprot.org/uniprot/M3ZYX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/8083:nfe2l1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QIC0 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/8083:LOC102223459 ^@ http://purl.uniprot.org/uniprot/M4AY22 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/8083:cnnm2 ^@ http://purl.uniprot.org/uniprot/M3ZCW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ACDP family.|||Cell membrane|||Membrane|||Metal transporter. http://togogenome.org/gene/8083:LOC102232522 ^@ http://purl.uniprot.org/uniprot/A0A3B5QDY5|||http://purl.uniprot.org/uniprot/M3ZXV5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:LOC102225475 ^@ http://purl.uniprot.org/uniprot/M4A4P6 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/8083:sf3b6 ^@ http://purl.uniprot.org/uniprot/M4A8H5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:mknk2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QRN0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:LOC102238311 ^@ http://purl.uniprot.org/uniprot/M3ZN02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/8083:phkg2 ^@ http://purl.uniprot.org/uniprot/M4AWL3 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily.|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/8083:ca8 ^@ http://purl.uniprot.org/uniprot/M4AVW5 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/8083:LOC102217425 ^@ http://purl.uniprot.org/uniprot/M3ZPF2 ^@ Similarity ^@ Belongs to the DIPK family. http://togogenome.org/gene/8083:fam114a1 ^@ http://purl.uniprot.org/uniprot/M4A4W6 ^@ Similarity ^@ Belongs to the FAM114 family. http://togogenome.org/gene/8083:LOC102225236 ^@ http://purl.uniprot.org/uniprot/M4AM10 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/8083:LOC102236366 ^@ http://purl.uniprot.org/uniprot/M4AUB5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/8083:suox ^@ http://purl.uniprot.org/uniprot/A0A3B5QN22 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.|||Mitochondrion intermembrane space http://togogenome.org/gene/8083:mybl1 ^@ http://purl.uniprot.org/uniprot/M3ZHI8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102238097 ^@ http://purl.uniprot.org/uniprot/M4ARZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/8083:ccz1 ^@ http://purl.uniprot.org/uniprot/M4AK97 ^@ Similarity ^@ Belongs to the CCZ1 family. http://togogenome.org/gene/8083:galc ^@ http://purl.uniprot.org/uniprot/M4AMQ3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 59 family. http://togogenome.org/gene/8083:LOC102217174 ^@ http://purl.uniprot.org/uniprot/A0A3B5PYS0 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Homodimer.|||Homodimerization via the leucine zipper domains is required for autophosphorylation. http://togogenome.org/gene/8083:LOC102223577 ^@ http://purl.uniprot.org/uniprot/M4AF37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102224970 ^@ http://purl.uniprot.org/uniprot/M3ZHY2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102221631 ^@ http://purl.uniprot.org/uniprot/M4ATC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM54 family.|||Membrane http://togogenome.org/gene/8083:ikbkb ^@ http://purl.uniprot.org/uniprot/A0A3B5Q4K8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/8083:bola1 ^@ http://purl.uniprot.org/uniprot/M4AYP0 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/8083:cntn2 ^@ http://purl.uniprot.org/uniprot/M3ZKB7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:hibch ^@ http://purl.uniprot.org/uniprot/M3ZW62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.|||Mitochondrion http://togogenome.org/gene/8083:LOC102219544 ^@ http://purl.uniprot.org/uniprot/M4A883 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/8083:LOC106700023 ^@ http://purl.uniprot.org/uniprot/M4AIZ0 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/8083:LOC102231977 ^@ http://purl.uniprot.org/uniprot/M4AYX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PUR DNA-binding protein family.|||Nucleus http://togogenome.org/gene/8083:elovl5 ^@ http://purl.uniprot.org/uniprot/M4A734 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL5 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||dendrite http://togogenome.org/gene/8083:lamp5 ^@ http://purl.uniprot.org/uniprot/A0A3B5R324 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/8083:limk2 ^@ http://purl.uniprot.org/uniprot/M4AUJ7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/8083:LOC102217650 ^@ http://purl.uniprot.org/uniprot/A0A3B5QE35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:ucp1 ^@ http://purl.uniprot.org/uniprot/M4A5W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:LOC102236300 ^@ http://purl.uniprot.org/uniprot/M4ARC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/8083:mrpl41 ^@ http://purl.uniprot.org/uniprot/M4AYS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL41 family.|||Mitochondrion http://togogenome.org/gene/8083:agmat ^@ http://purl.uniprot.org/uniprot/M4AD33 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/8083:LOC102233467 ^@ http://purl.uniprot.org/uniprot/M3ZVN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/8083:LOC102229982 ^@ http://purl.uniprot.org/uniprot/M4AD35 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:slc17a5 ^@ http://purl.uniprot.org/uniprot/M4ARV0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102228107 ^@ http://purl.uniprot.org/uniprot/M4AX34 ^@ Function|||Similarity ^@ Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.|||Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. http://togogenome.org/gene/8083:sh3rf1 ^@ http://purl.uniprot.org/uniprot/M4AI75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SH3RF family.|||lamellipodium|||perinuclear region|||trans-Golgi network http://togogenome.org/gene/8083:LOC102219886 ^@ http://purl.uniprot.org/uniprot/A0A3B5QH09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.|||Nucleus http://togogenome.org/gene/8083:LOC102219136 ^@ http://purl.uniprot.org/uniprot/M4AE45 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102227504 ^@ http://purl.uniprot.org/uniprot/M4AMQ5 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/8083:adam17 ^@ http://purl.uniprot.org/uniprot/M4A5X7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102216803 ^@ http://purl.uniprot.org/uniprot/A0A3B5PV92 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/8083:LOC102237388 ^@ http://purl.uniprot.org/uniprot/M3ZD55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/8083:dmgdh ^@ http://purl.uniprot.org/uniprot/M4AWD7 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/8083:cacng3 ^@ http://purl.uniprot.org/uniprot/M3ZDA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane http://togogenome.org/gene/8083:LOC102229288 ^@ http://purl.uniprot.org/uniprot/M3ZY63 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:LOC102221058 ^@ http://purl.uniprot.org/uniprot/A0A3B5PR27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:gnb4 ^@ http://purl.uniprot.org/uniprot/M4AUW2 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/8083:dxo ^@ http://purl.uniprot.org/uniprot/A0A3B5PX66 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DXO/Dom3Z family.|||Binds 2 magnesium ions.|||Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.|||Nucleus http://togogenome.org/gene/8083:LOC106699846 ^@ http://purl.uniprot.org/uniprot/M3ZEN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/8083:ddo ^@ http://purl.uniprot.org/uniprot/M4ALG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/8083:dpep1 ^@ http://purl.uniprot.org/uniprot/M4AVA6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/8083:ssbp2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QC28 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:coq6 ^@ http://purl.uniprot.org/uniprot/M4AL43 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UbiH/COQ6 family.|||Cell projection|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.|||FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.|||Golgi apparatus|||Mitochondrion inner membrane http://togogenome.org/gene/8083:pik3c2b ^@ http://purl.uniprot.org/uniprot/M4ADQ2 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/8083:nr4a2 ^@ http://purl.uniprot.org/uniprot/M4AA14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102222297 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q075 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/8083:mospd1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUH6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC106699914 ^@ http://purl.uniprot.org/uniprot/A0A3B5R117 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/8083:ano3 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102236049 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0S3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tim44 family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102218026 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q433 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/8083:fam183a ^@ http://purl.uniprot.org/uniprot/A0A3B5PTS9 ^@ Similarity ^@ Belongs to the CFAP144 family. http://togogenome.org/gene/8083:LOC102235802 ^@ http://purl.uniprot.org/uniprot/A0A3B5QVP9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102227425 ^@ http://purl.uniprot.org/uniprot/M4AQ05 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||synaptic vesicle membrane http://togogenome.org/gene/8083:LOC102224904 ^@ http://purl.uniprot.org/uniprot/M3ZJW8 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/8083:LOC102227083 ^@ http://purl.uniprot.org/uniprot/M3ZFQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/8083:icmt ^@ http://purl.uniprot.org/uniprot/A0A3B5R7L3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.|||Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:atp5f1b ^@ http://purl.uniprot.org/uniprot/M4AHL5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/8083:LOC102227435 ^@ http://purl.uniprot.org/uniprot/M3ZJR5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/8083:LOC102229361 ^@ http://purl.uniprot.org/uniprot/A0A3B5PQ28 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/8083:scrn3 ^@ http://purl.uniprot.org/uniprot/M3ZT71 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/8083:gpr157 ^@ http://purl.uniprot.org/uniprot/M4A5U3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 5 family.|||Membrane http://togogenome.org/gene/8083:prkab1 ^@ http://purl.uniprot.org/uniprot/M3ZHN7 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/8083:LOC102236092 ^@ http://purl.uniprot.org/uniprot/M3ZG40 ^@ Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family. http://togogenome.org/gene/8083:smc6 ^@ http://purl.uniprot.org/uniprot/M3ZZ94 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/8083:LOC102224351 ^@ http://purl.uniprot.org/uniprot/A0A3B5QUW1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:taf7l ^@ http://purl.uniprot.org/uniprot/M4AG96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF7 family.|||Nucleus http://togogenome.org/gene/8083:timm8a ^@ http://purl.uniprot.org/uniprot/A0A3B5QK75 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/8083:c2h11orf58 ^@ http://purl.uniprot.org/uniprot/M4ACL0 ^@ Similarity ^@ Belongs to the SMAP family. http://togogenome.org/gene/8083:psmb2 ^@ http://purl.uniprot.org/uniprot/M4AQB2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102238154 ^@ http://purl.uniprot.org/uniprot/M3ZGY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/8083:casp9 ^@ http://purl.uniprot.org/uniprot/M4AY86 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/8083:LOC102236922 ^@ http://purl.uniprot.org/uniprot/M4AZ39 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/8083:LOC102220954 ^@ http://purl.uniprot.org/uniprot/A0A3B5PSI9 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/8083:nek3 ^@ http://purl.uniprot.org/uniprot/M3ZYY9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:LOC102222748 ^@ http://purl.uniprot.org/uniprot/M4A483 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/8083:gsk3a ^@ http://purl.uniprot.org/uniprot/M4A8P0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/8083:LOC102219509 ^@ http://purl.uniprot.org/uniprot/A0A3B5QF26 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Nucleus|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/8083:LOC102237476 ^@ http://purl.uniprot.org/uniprot/A0A3B5R4H9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||Membrane|||Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group. http://togogenome.org/gene/8083:rp2 ^@ http://purl.uniprot.org/uniprot/M4ANI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.|||Belongs to the TBCC family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:b4galt4 ^@ http://purl.uniprot.org/uniprot/M4AEV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/8083:LOC102233238 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/8083:LOC102229665 ^@ http://purl.uniprot.org/uniprot/M3ZIE6 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:LOC102236843 ^@ http://purl.uniprot.org/uniprot/M3ZV57 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102233437 ^@ http://purl.uniprot.org/uniprot/M4AYD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PUR DNA-binding protein family.|||Nucleus http://togogenome.org/gene/8083:LOC102218527 ^@ http://purl.uniprot.org/uniprot/A0A3B5RFH6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:LOC102218017 ^@ http://purl.uniprot.org/uniprot/M4ABW7 ^@ Subunit ^@ Interacts with ATP6V0C. http://togogenome.org/gene/8083:LOC102231280 ^@ http://purl.uniprot.org/uniprot/M3ZKJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/8083:ap1m2 ^@ http://purl.uniprot.org/uniprot/M3ZY91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Golgi apparatus|||Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.|||clathrin-coated vesicle membrane http://togogenome.org/gene/8083:utp3 ^@ http://purl.uniprot.org/uniprot/M4ARN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAS10 family.|||nucleolus http://togogenome.org/gene/8083:LOC102222835 ^@ http://purl.uniprot.org/uniprot/M4A5K2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:rnf13 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBK3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102216843 ^@ http://purl.uniprot.org/uniprot/A0A3B5R853 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudE family.|||centrosome|||spindle http://togogenome.org/gene/8083:srp68 ^@ http://purl.uniprot.org/uniprot/M3ZV90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP68 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.|||Cytoplasm|||nucleolus http://togogenome.org/gene/8083:prrx1 ^@ http://purl.uniprot.org/uniprot/M3ZTA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/8083:ptn ^@ http://purl.uniprot.org/uniprot/M4ATD0 ^@ Similarity ^@ Belongs to the pleiotrophin family. http://togogenome.org/gene/8083:LOC102233898 ^@ http://purl.uniprot.org/uniprot/M4ATI1 ^@ Similarity ^@ Belongs to the GCF family. http://togogenome.org/gene/8083:uhrf2 ^@ http://purl.uniprot.org/uniprot/M3ZSL9 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.|||Nucleus|||The YDG domain mediates the interaction with histone H3.|||The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3). http://togogenome.org/gene/8083:parva ^@ http://purl.uniprot.org/uniprot/A0A3B5R5G6 ^@ Similarity ^@ Belongs to the parvin family. http://togogenome.org/gene/8083:atad2b ^@ http://purl.uniprot.org/uniprot/M3ZMQ1 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/8083:me1 ^@ http://purl.uniprot.org/uniprot/M3ZXG5 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/8083:tmbim6 ^@ http://purl.uniprot.org/uniprot/M4A4L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/8083:grem2 ^@ http://purl.uniprot.org/uniprot/M3ZNN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/8083:lactb2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PPQ3 ^@ Function|||Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.|||Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability. http://togogenome.org/gene/8083:LOC102232127 ^@ http://purl.uniprot.org/uniprot/M3ZP84 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/8083:LOC102232077 ^@ http://purl.uniprot.org/uniprot/M3ZI99 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/8083:rfc5 ^@ http://purl.uniprot.org/uniprot/M3ZK31 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/8083:hbegf ^@ http://purl.uniprot.org/uniprot/D1MGM3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:tmem39a ^@ http://purl.uniprot.org/uniprot/M3ZI64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/8083:meis2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHD4|||http://purl.uniprot.org/uniprot/M4A553 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/8083:LOC111605753 ^@ http://purl.uniprot.org/uniprot/M3ZGH5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102236651 ^@ http://purl.uniprot.org/uniprot/M3ZLP4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/8083:LOC102219542 ^@ http://purl.uniprot.org/uniprot/M4AFL5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102228435 ^@ http://purl.uniprot.org/uniprot/M4A7S3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space http://togogenome.org/gene/8083:scg5 ^@ http://purl.uniprot.org/uniprot/M3ZZS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 7B2 family.|||Secreted http://togogenome.org/gene/8083:LOC102224572 ^@ http://purl.uniprot.org/uniprot/M4A118 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PWP2 family.|||nucleolus http://togogenome.org/gene/8083:htra2 ^@ http://purl.uniprot.org/uniprot/M4AG77 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/8083:sdhaf4 ^@ http://purl.uniprot.org/uniprot/A0A3B5PT73 ^@ Similarity ^@ Belongs to the SDHAF4 family. http://togogenome.org/gene/8083:cdv3 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVS6 ^@ Similarity ^@ Belongs to the CDV3 family. http://togogenome.org/gene/8083:cpa6 ^@ http://purl.uniprot.org/uniprot/M4A6P6 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/8083:LOC102237839 ^@ http://purl.uniprot.org/uniprot/A0A3B5RC79 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:LOC102221398 ^@ http://purl.uniprot.org/uniprot/M3ZNE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:LOC102231820 ^@ http://purl.uniprot.org/uniprot/M4AF54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/8083:LOC102236570 ^@ http://purl.uniprot.org/uniprot/A0A3B5PQ80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/8083:farsb ^@ http://purl.uniprot.org/uniprot/M4AYF6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the EF-1-beta/EF-1-delta family.|||Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.|||EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.|||EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. http://togogenome.org/gene/8083:LOC102226209 ^@ http://purl.uniprot.org/uniprot/M4AN78 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:kctd3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPI4 ^@ Similarity ^@ Belongs to the KCTD3 family. http://togogenome.org/gene/8083:ribc1 ^@ http://purl.uniprot.org/uniprot/M4A939 ^@ Similarity ^@ Belongs to the RIB43A family. http://togogenome.org/gene/8083:slc39a12 ^@ http://purl.uniprot.org/uniprot/M3ZJ83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Membrane http://togogenome.org/gene/8083:LOC102238406 ^@ http://purl.uniprot.org/uniprot/M3ZHN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102219080 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAF7 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/8083:phkg1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QSV8 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily.|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/8083:LOC102237399 ^@ http://purl.uniprot.org/uniprot/A0A3B5R1J3 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:elavl4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QIN0|||http://purl.uniprot.org/uniprot/A0A3B5QJD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm|||Perikaryon|||axon|||dendrite|||growth cone http://togogenome.org/gene/8083:lsm7 ^@ http://purl.uniprot.org/uniprot/M4AW21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/8083:LOC102218888 ^@ http://purl.uniprot.org/uniprot/A0A3B5QKU4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8083:trub2 ^@ http://purl.uniprot.org/uniprot/M4AM15 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/8083:cers2 ^@ http://purl.uniprot.org/uniprot/M4AQ27 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/8083:LOC102232814 ^@ http://purl.uniprot.org/uniprot/M3ZGF6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:rabep1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q6W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rabaptin family.|||Cytoplasm|||Early endosome|||Endosome http://togogenome.org/gene/8083:lig3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QD23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/8083:LOC102235276 ^@ http://purl.uniprot.org/uniprot/A0A3B5QVD3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:sft2d1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/8083:LOC102237313 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPW6 ^@ Function|||Similarity ^@ Belongs to the PNP/MTAP phosphorylase family.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/8083:LOC102216936 ^@ http://purl.uniprot.org/uniprot/A0A3B5QRU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus|||Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. http://togogenome.org/gene/8083:LOC102228839 ^@ http://purl.uniprot.org/uniprot/M4ACH9 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:vps26b ^@ http://purl.uniprot.org/uniprot/M4AUC2 ^@ Similarity ^@ Belongs to the VPS26 family. http://togogenome.org/gene/8083:LOC102219615 ^@ http://purl.uniprot.org/uniprot/M3ZHR7 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/8083:nsun5 ^@ http://purl.uniprot.org/uniprot/M4AXR7 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/8083:LOC102217146 ^@ http://purl.uniprot.org/uniprot/A0A3B5RF74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/8083:uba5 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.|||Golgi apparatus http://togogenome.org/gene/8083:bcl9 ^@ http://purl.uniprot.org/uniprot/M3ZPG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BCL9 family.|||Nucleus http://togogenome.org/gene/8083:chrm4 ^@ http://purl.uniprot.org/uniprot/A0A3B5R3V1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102228588 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZQ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:taf5 ^@ http://purl.uniprot.org/uniprot/M3ZGL3 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/8083:nudt19 ^@ http://purl.uniprot.org/uniprot/A0A3B5QLX3 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/8083:tp53inp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8X3 ^@ Subcellular Location Annotation ^@ PML body|||autophagosome|||cytosol http://togogenome.org/gene/8083:slc35e1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWR8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:ran ^@ http://purl.uniprot.org/uniprot/M4A655 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ran family.|||GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.|||Nucleus http://togogenome.org/gene/8083:LOC102233023 ^@ http://purl.uniprot.org/uniprot/M4ALR5 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/8083:LOC102233332 ^@ http://purl.uniprot.org/uniprot/M4APE2 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/8083:kcnb2 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDD8 ^@ Subcellular Location Annotation ^@ Membrane|||Perikaryon|||dendrite http://togogenome.org/gene/8083:upf2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUU1|||http://purl.uniprot.org/uniprot/M4AS28 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:ubr3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZH1 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/8083:LOC102218379 ^@ http://purl.uniprot.org/uniprot/A0A3B5R724 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8083:LOC102231119 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/8083:tmem255a ^@ http://purl.uniprot.org/uniprot/A0A3B5R9X1|||http://purl.uniprot.org/uniprot/A0A3B5RB00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM255 family.|||Membrane http://togogenome.org/gene/8083:ndnf ^@ http://purl.uniprot.org/uniprot/M4AHA8 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/8083:rab9a ^@ http://purl.uniprot.org/uniprot/M4AYS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||phagosome membrane http://togogenome.org/gene/8083:cript ^@ http://purl.uniprot.org/uniprot/A0A3B5PRK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRIPT family.|||Cytoplasm http://togogenome.org/gene/8083:ist1 ^@ http://purl.uniprot.org/uniprot/M4AV58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IST1 family.|||Cytoplasmic vesicle|||Nucleus envelope http://togogenome.org/gene/8083:phyhipl ^@ http://purl.uniprot.org/uniprot/A0A3B5R3Y3 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/8083:LOC102237372 ^@ http://purl.uniprot.org/uniprot/M4AVS4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8083:LOC102218673 ^@ http://purl.uniprot.org/uniprot/M4AN82 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/8083:LOC102237223 ^@ http://purl.uniprot.org/uniprot/M3ZDI3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:rpgrip1l ^@ http://purl.uniprot.org/uniprot/M3ZX20 ^@ Similarity ^@ Belongs to the RPGRIP1 family. http://togogenome.org/gene/8083:fgf17 ^@ http://purl.uniprot.org/uniprot/M3ZP39 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:prepl ^@ http://purl.uniprot.org/uniprot/M4AUH1 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/8083:LOC106699670 ^@ http://purl.uniprot.org/uniprot/A0A3B5QM86 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:LOC102237080 ^@ http://purl.uniprot.org/uniprot/M3ZL25 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/8083:LOC102227141 ^@ http://purl.uniprot.org/uniprot/M4AR68 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/8083:LOC102226897 ^@ http://purl.uniprot.org/uniprot/M4A756 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:epcam ^@ http://purl.uniprot.org/uniprot/M3ZZ46 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPCAM family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:ube2c ^@ http://purl.uniprot.org/uniprot/A0A3B5QL66 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:LOC102226559 ^@ http://purl.uniprot.org/uniprot/M4AFA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102217909 ^@ http://purl.uniprot.org/uniprot/A0A3B5QVG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8083:LOC102228756 ^@ http://purl.uniprot.org/uniprot/M3ZDR8 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/8083:LOC102219960 ^@ http://purl.uniprot.org/uniprot/A0A3B5PXF2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/8083:LOC102233553 ^@ http://purl.uniprot.org/uniprot/M3ZHT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/8083:LOC102218999 ^@ http://purl.uniprot.org/uniprot/A0A3B5QEW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 26 family.|||Nucleus http://togogenome.org/gene/8083:gfm1 ^@ http://purl.uniprot.org/uniprot/M3ZDH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.|||Mitochondrion http://togogenome.org/gene/8083:LOC102221726 ^@ http://purl.uniprot.org/uniprot/M4AFJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:tp53bp2 ^@ http://purl.uniprot.org/uniprot/M3ZKY1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:tcp11l1 ^@ http://purl.uniprot.org/uniprot/M4ALP9 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/8083:rbp2 ^@ http://purl.uniprot.org/uniprot/M3ZWG7 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8083:sparc ^@ http://purl.uniprot.org/uniprot/M4AXV2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.|||Belongs to the SPARC family.|||Membrane|||basement membrane http://togogenome.org/gene/8083:LOC102237659 ^@ http://purl.uniprot.org/uniprot/M3ZYR9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8083:strn4 ^@ http://purl.uniprot.org/uniprot/A0A3B5REW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat striatin family.|||Membrane http://togogenome.org/gene/8083:ddx54 ^@ http://purl.uniprot.org/uniprot/M3ZT06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.|||nucleolus http://togogenome.org/gene/8083:LOC102229768 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q879 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102233127 ^@ http://purl.uniprot.org/uniprot/A0A3B5QEH7 ^@ Similarity ^@ Belongs to the MARCKS family. http://togogenome.org/gene/8083:apom ^@ http://purl.uniprot.org/uniprot/M4AG02 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family. Highly divergent.|||Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.|||Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.|||Secreted http://togogenome.org/gene/8083:sept10 ^@ http://purl.uniprot.org/uniprot/M4APB0 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/8083:LOC102226240 ^@ http://purl.uniprot.org/uniprot/M4ACD5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/8083:mboat7 ^@ http://purl.uniprot.org/uniprot/A0A3B5R2C4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102219478 ^@ http://purl.uniprot.org/uniprot/M4AWC3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Heterodimer; with an rxr molecule. Binds DNA preferentially as a rar/rxr heterodimer.|||Nucleus http://togogenome.org/gene/8083:alox5 ^@ http://purl.uniprot.org/uniprot/A0A3B5PTG7 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the lipoxygenase family.|||Binds 1 Fe cation per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:c16h16orf58 ^@ http://purl.uniprot.org/uniprot/M4AUL9 ^@ Similarity ^@ Belongs to the RUS1 family. http://togogenome.org/gene/8083:LOC102216524 ^@ http://purl.uniprot.org/uniprot/M3ZDM1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:atp5f1d ^@ http://purl.uniprot.org/uniprot/A0A3B5QK56 ^@ Similarity ^@ Belongs to the ATPase epsilon chain family. http://togogenome.org/gene/8083:LOC102230898 ^@ http://purl.uniprot.org/uniprot/M4ARC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:taf6l ^@ http://purl.uniprot.org/uniprot/M4A066 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF6 family.|||Nucleus http://togogenome.org/gene/8083:panx1 ^@ http://purl.uniprot.org/uniprot/M3ZS53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/8083:LOC102237180 ^@ http://purl.uniprot.org/uniprot/M3ZZQ5 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/8083:LOC102224346 ^@ http://purl.uniprot.org/uniprot/M4A905 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/8083:fen1 ^@ http://purl.uniprot.org/uniprot/Q5I4H3 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. Three molecules of fen1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Mitochondrion|||Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.|||nucleolus|||nucleoplasm http://togogenome.org/gene/8083:polr3f ^@ http://purl.uniprot.org/uniprot/M3ZQY4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/8083:zic3 ^@ http://purl.uniprot.org/uniprot/M4AG35 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/8083:LOC102233261 ^@ http://purl.uniprot.org/uniprot/A0A3B5QP01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Membrane http://togogenome.org/gene/8083:dhtkd1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PTK2 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/8083:rps21 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPQ5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS21 family.|||Component of the 40S small ribosomal subunit.|||Endoplasmic reticulum|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/8083:LOC102233781 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102222601 ^@ http://purl.uniprot.org/uniprot/M3ZJA4 ^@ Similarity ^@ In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/8083:btg1 ^@ http://purl.uniprot.org/uniprot/M4AW14 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/8083:LOC102233532 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWL9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/8083:grm1 ^@ http://purl.uniprot.org/uniprot/M3ZLA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:sqle ^@ http://purl.uniprot.org/uniprot/M3ZMI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the squalene monooxygenase family.|||Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.|||Endoplasmic reticulum membrane http://togogenome.org/gene/8083:ppp1r1b ^@ http://purl.uniprot.org/uniprot/A0A3B5QV14 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/8083:sox1 ^@ http://purl.uniprot.org/uniprot/M4AYE9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102224008 ^@ http://purl.uniprot.org/uniprot/A0A3B5QY45 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/8083:LOC102222936 ^@ http://purl.uniprot.org/uniprot/M4ACY4 ^@ Function|||Subcellular Location Annotation ^@ Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.|||Membrane|||cytoskeleton|||filopodium|||ruffle http://togogenome.org/gene/8083:lsm3 ^@ http://purl.uniprot.org/uniprot/M4A3X3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/8083:LOC102226607 ^@ http://purl.uniprot.org/uniprot/M3ZS40 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/8083:htra3 ^@ http://purl.uniprot.org/uniprot/A0A3B5R3I0 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/8083:LOC102234393 ^@ http://purl.uniprot.org/uniprot/M4AWH8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102236105 ^@ http://purl.uniprot.org/uniprot/M4ABC7 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/8083:dnaaf4 ^@ http://purl.uniprot.org/uniprot/M3ZW97 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Dynein axonemal particle|||neuron projection http://togogenome.org/gene/8083:LOC102228925 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7T3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:uxs1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QU13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/8083:LOC102233807 ^@ http://purl.uniprot.org/uniprot/M4AF11 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/8083:stx5 ^@ http://purl.uniprot.org/uniprot/M3ZLX4 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/8083:snapin ^@ http://purl.uniprot.org/uniprot/A0A3B5PZI1 ^@ Similarity ^@ Belongs to the SNAPIN family. http://togogenome.org/gene/8083:LOC102236055 ^@ http://purl.uniprot.org/uniprot/M4A979 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102238325 ^@ http://purl.uniprot.org/uniprot/A0A3B5R422 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/8083:rps29 ^@ http://purl.uniprot.org/uniprot/M4A1J9 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/8083:adck1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q4R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family.|||Secreted http://togogenome.org/gene/8083:LOC102218271 ^@ http://purl.uniprot.org/uniprot/M4B0S4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:llgl1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVP2 ^@ Similarity ^@ Belongs to the WD repeat L(2)GL family. http://togogenome.org/gene/8083:LOC102235581 ^@ http://purl.uniprot.org/uniprot/A0A3B5QSU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/8083:LOC102220447 ^@ http://purl.uniprot.org/uniprot/M4A6G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:sox21 ^@ http://purl.uniprot.org/uniprot/M4AYS5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102232462 ^@ http://purl.uniprot.org/uniprot/M3ZWS9 ^@ Similarity ^@ Belongs to the CEP170 family. http://togogenome.org/gene/8083:top3b ^@ http://purl.uniprot.org/uniprot/M3ZQ84 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/8083:qrsl1 ^@ http://purl.uniprot.org/uniprot/M4AW57 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/8083:hspd1 ^@ http://purl.uniprot.org/uniprot/M3ZUM7 ^@ Similarity ^@ Belongs to the chaperonin (HSP60) family. http://togogenome.org/gene/8083:sdf4 ^@ http://purl.uniprot.org/uniprot/M4ADQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CREC family.|||Golgi apparatus lumen http://togogenome.org/gene/8083:galnt2 ^@ http://purl.uniprot.org/uniprot/M4AKZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:LOC102227853 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0J3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102227961 ^@ http://purl.uniprot.org/uniprot/M3ZHI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shroom family.|||cytoskeleton http://togogenome.org/gene/8083:LOC102225771 ^@ http://purl.uniprot.org/uniprot/M4AQ50 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 zinc ion per subunit.|||Homotetramer.|||Involved in the regulation of homocysteine metabolism. http://togogenome.org/gene/8083:LOC102218394 ^@ http://purl.uniprot.org/uniprot/M4AM81 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/8083:rpl4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQA6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/8083:ndufaf7 ^@ http://purl.uniprot.org/uniprot/M3ZZA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Belongs to the NDUFAF7 family.|||Mitochondrion http://togogenome.org/gene/8083:LOC102219849 ^@ http://purl.uniprot.org/uniprot/M4AGU5 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/8083:LOC102235379 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAA7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8083:skiv2l ^@ http://purl.uniprot.org/uniprot/M4AI56 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:ldlrad4 ^@ http://purl.uniprot.org/uniprot/M3ZK98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMEPA1 family.|||Early endosome membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/8083:aass ^@ http://purl.uniprot.org/uniprot/M3ZJQ6 ^@ Similarity ^@ In the C-terminal section; belongs to the saccharopine dehydrogenase family.|||In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/8083:pik3r1 ^@ http://purl.uniprot.org/uniprot/M4AW07 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/8083:LOC102224964 ^@ http://purl.uniprot.org/uniprot/M3ZHH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/8083:LOC102235839 ^@ http://purl.uniprot.org/uniprot/M4A122 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:cxcr4 ^@ http://purl.uniprot.org/uniprot/M3ZN98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/8083:tmem218 ^@ http://purl.uniprot.org/uniprot/A0A3B5RE32 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM218 family.|||May be involved in ciliary biogenesis or function.|||Membrane|||cilium http://togogenome.org/gene/8083:prpf19 ^@ http://purl.uniprot.org/uniprot/M4A220 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat PRP19 family.|||Homotetramer.|||Lipid droplet|||Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.|||nucleoplasm http://togogenome.org/gene/8083:LOC102230367 ^@ http://purl.uniprot.org/uniprot/A0A3B5QIJ4 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/8083:slc35b1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQ74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/8083:LOC102224774 ^@ http://purl.uniprot.org/uniprot/M4A1G0 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/8083:ifi30 ^@ http://purl.uniprot.org/uniprot/M3ZJV9 ^@ Similarity|||Subunit ^@ Belongs to the GILT family.|||Dimer; disulfide-linked. http://togogenome.org/gene/8083:LOC102234300 ^@ http://purl.uniprot.org/uniprot/M4AAZ6 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/8083:pappa2 ^@ http://purl.uniprot.org/uniprot/M4AVE2 ^@ Caution|||Similarity ^@ Belongs to the peptidase M43B family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:c10h8orf33 ^@ http://purl.uniprot.org/uniprot/A0A3B5PX13 ^@ Similarity ^@ Belongs to the UPF0488 family. http://togogenome.org/gene/8083:LOC102217479 ^@ http://purl.uniprot.org/uniprot/M4ATP2 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/8083:btbd10 ^@ http://purl.uniprot.org/uniprot/M3ZLJ7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:LOC102228800 ^@ http://purl.uniprot.org/uniprot/M3ZLD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:LOC102217813 ^@ http://purl.uniprot.org/uniprot/M3ZRH5 ^@ Similarity ^@ Belongs to the asteroid family. http://togogenome.org/gene/8083:LOC102237689 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.|||Membrane http://togogenome.org/gene/8083:myo1c ^@ http://purl.uniprot.org/uniprot/A0A3B5R444 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/8083:LOC102232342 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAQ2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:ruvbl2 ^@ http://purl.uniprot.org/uniprot/M3ZUP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||Dynein axonemal particle|||Nucleus|||Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. http://togogenome.org/gene/8083:cct3 ^@ http://purl.uniprot.org/uniprot/M4AT35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102226182 ^@ http://purl.uniprot.org/uniprot/M4A3S7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:pigs ^@ http://purl.uniprot.org/uniprot/M4A8M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGS family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:rab3gap1 ^@ http://purl.uniprot.org/uniprot/M4AJH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab3-GAP catalytic subunit family.|||Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/8083:LOC102226557 ^@ http://purl.uniprot.org/uniprot/M4AW64 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8083:mtmr7 ^@ http://purl.uniprot.org/uniprot/M4ASR5 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/8083:LOC102228517 ^@ http://purl.uniprot.org/uniprot/M4ANQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/8083:gpam ^@ http://purl.uniprot.org/uniprot/M4ATT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.|||Mitochondrion outer membrane http://togogenome.org/gene/8083:mrps25 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS25 family.|||Mitochondrion http://togogenome.org/gene/8083:evx1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7Q5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102228305 ^@ http://purl.uniprot.org/uniprot/M4AC35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/8083:LOC102229336 ^@ http://purl.uniprot.org/uniprot/M4AX39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMG-CoA reductase family.|||Endoplasmic reticulum membrane|||Membrane|||Peroxisome membrane http://togogenome.org/gene/8083:rarb ^@ http://purl.uniprot.org/uniprot/M4AJM4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Heterodimer; with an rxr molecule. Binds DNA preferentially as a rar/rxr heterodimer.|||Nucleus http://togogenome.org/gene/8083:LOC102221560 ^@ http://purl.uniprot.org/uniprot/M4A558 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/8083:ccnl1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QE60 ^@ Similarity|||Subunit ^@ Belongs to the cyclin family.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. http://togogenome.org/gene/8083:LOC102236323 ^@ http://purl.uniprot.org/uniprot/M3ZJC3 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/8083:pdhb ^@ http://purl.uniprot.org/uniprot/M4A300 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. http://togogenome.org/gene/8083:LOC102223230 ^@ http://purl.uniprot.org/uniprot/M4A4P4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/8083:LOC102216654 ^@ http://purl.uniprot.org/uniprot/M3ZNM6 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/8083:gchfr ^@ http://purl.uniprot.org/uniprot/M3ZX81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GFRP family.|||Membrane|||Nucleus membrane|||cytosol http://togogenome.org/gene/8083:galnt10 ^@ http://purl.uniprot.org/uniprot/M4ALX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:LOC102219816 ^@ http://purl.uniprot.org/uniprot/M3ZQ51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tango11 family.|||Membrane|||Mitochondrion outer membrane|||Peroxisome|||Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. http://togogenome.org/gene/8083:triqk ^@ http://purl.uniprot.org/uniprot/A0A3B5QCZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIQK family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:cdc42ep5 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/8083:LOC102233212 ^@ http://purl.uniprot.org/uniprot/M4ARB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parathyroid hormone family.|||Secreted http://togogenome.org/gene/8083:LOC102227856 ^@ http://purl.uniprot.org/uniprot/M3ZFL4 ^@ Similarity|||Subunit ^@ Belongs to the ENDOU family.|||Monomer. http://togogenome.org/gene/8083:wdr35 ^@ http://purl.uniprot.org/uniprot/A0A3B5PPB9 ^@ Subcellular Location Annotation ^@ centrosome|||cilium basal body http://togogenome.org/gene/8083:LOC102232352 ^@ http://purl.uniprot.org/uniprot/M4AGJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/8083:hook1 ^@ http://purl.uniprot.org/uniprot/M4AB19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hook family.|||cytoskeleton http://togogenome.org/gene/8083:LOC102227933 ^@ http://purl.uniprot.org/uniprot/M4ADY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/8083:gipc3 ^@ http://purl.uniprot.org/uniprot/M3ZV63 ^@ Similarity ^@ Belongs to the GIPC family. http://togogenome.org/gene/8083:LOC102237692 ^@ http://purl.uniprot.org/uniprot/A0A3B5QF22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/8083:sfr1 ^@ http://purl.uniprot.org/uniprot/M4AER0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SFR1/MEI5 family.|||Nucleus http://togogenome.org/gene/8083:gstz1 ^@ http://purl.uniprot.org/uniprot/M4AKX4 ^@ Similarity ^@ Belongs to the GST superfamily. Zeta family. http://togogenome.org/gene/8083:paip2 ^@ http://purl.uniprot.org/uniprot/M4AI33 ^@ Similarity ^@ Belongs to the PAIP2 family. http://togogenome.org/gene/8083:sec13 ^@ http://purl.uniprot.org/uniprot/M4AY57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Lysosome membrane http://togogenome.org/gene/8083:smim7 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHU6 ^@ Similarity ^@ Belongs to the SMIM7 family. http://togogenome.org/gene/8083:dolpp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGD5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dolichyldiphosphatase family.|||Endoplasmic reticulum membrane|||Membrane|||Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. http://togogenome.org/gene/8083:fam103a1 ^@ http://purl.uniprot.org/uniprot/M4AL81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAM family.|||Nucleus http://togogenome.org/gene/8083:amfr ^@ http://purl.uniprot.org/uniprot/M4ASK3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102220119 ^@ http://purl.uniprot.org/uniprot/M3ZZE6 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:cdk9 ^@ http://purl.uniprot.org/uniprot/M3ZNQ8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:LOC102218003 ^@ http://purl.uniprot.org/uniprot/M4A873 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/8083:copz1 ^@ http://purl.uniprot.org/uniprot/M4A0W6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes small subunit family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. http://togogenome.org/gene/8083:LOC102237443 ^@ http://purl.uniprot.org/uniprot/M4AAF8 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/8083:mrpl3 ^@ http://purl.uniprot.org/uniprot/M3ZK62 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/8083:LOC102220955 ^@ http://purl.uniprot.org/uniprot/A0A3B5QK28 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. http://togogenome.org/gene/8083:pi4k2a ^@ http://purl.uniprot.org/uniprot/A0A3B5R6B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.|||Membrane http://togogenome.org/gene/8083:piwil2 ^@ http://purl.uniprot.org/uniprot/M3ZS69 ^@ Similarity ^@ Belongs to the argonaute family. http://togogenome.org/gene/8083:LOC102233725 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CART family.|||Secreted http://togogenome.org/gene/8083:b3galnt2 ^@ http://purl.uniprot.org/uniprot/M3ZWI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:emc4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QXC0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC4 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:prkar1a ^@ http://purl.uniprot.org/uniprot/M4API9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:lancl1 ^@ http://purl.uniprot.org/uniprot/M4A0C4 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/8083:LOC102223293 ^@ http://purl.uniprot.org/uniprot/M3ZVW2 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/8083:rft1 ^@ http://purl.uniprot.org/uniprot/M3ZI14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RFT1 family.|||May be involved in N-linked oligosaccharide assembly.|||Membrane http://togogenome.org/gene/8083:LOC102226312 ^@ http://purl.uniprot.org/uniprot/M4AFU1 ^@ Similarity ^@ Belongs to the glycosyltransferase 25 family. http://togogenome.org/gene/8083:LOC102218425 ^@ http://purl.uniprot.org/uniprot/M4AIC1 ^@ Function|||Similarity ^@ Belongs to the DDAH family.|||Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. http://togogenome.org/gene/8083:psenen ^@ http://purl.uniprot.org/uniprot/A0A3B5QD52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PEN-2 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/8083:LOC102220404 ^@ http://purl.uniprot.org/uniprot/A0A3B5QT52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cleavage furrow|||Midbody|||cilium axoneme|||kinetochore|||spindle http://togogenome.org/gene/8083:dcaf11 ^@ http://purl.uniprot.org/uniprot/M3ZVF6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the WD repeat LEC14B family.|||Interacts with DDB1 and CUL4A.|||May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. http://togogenome.org/gene/8083:timm17a ^@ http://purl.uniprot.org/uniprot/A0A3B5QRE5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102234260 ^@ http://purl.uniprot.org/uniprot/A0A3B5QE77 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/8083:LOC102219560 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:fdps ^@ http://purl.uniprot.org/uniprot/M4ANZ4 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/8083:glrx ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8I9 ^@ Function|||Similarity ^@ Belongs to the glutaredoxin family.|||Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. http://togogenome.org/gene/8083:ebag9 ^@ http://purl.uniprot.org/uniprot/M3ZY03 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. http://togogenome.org/gene/8083:LOC102220574 ^@ http://purl.uniprot.org/uniprot/M4AFQ7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TIKI family.|||Cell membrane|||Divalent metal cations. Mn(2+) or Co(2+).|||Membrane|||Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. http://togogenome.org/gene/8083:bfsp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R159 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||cell cortex|||cytoskeleton http://togogenome.org/gene/8083:eif3a ^@ http://purl.uniprot.org/uniprot/M4A0J0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit A family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Cytoplasm|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. http://togogenome.org/gene/8083:mrps9 ^@ http://purl.uniprot.org/uniprot/A0A3B5QXV7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/8083:fam207a ^@ http://purl.uniprot.org/uniprot/A0A3B5R9B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLX9 family.|||nucleolus http://togogenome.org/gene/8083:LOC102226907 ^@ http://purl.uniprot.org/uniprot/A0A3B5QXV0 ^@ Domain|||Similarity ^@ Belongs to the CAMSAP1 family.|||The CKK domain binds microtubules. http://togogenome.org/gene/8083:mrs2 ^@ http://purl.uniprot.org/uniprot/M4A8V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102222702 ^@ http://purl.uniprot.org/uniprot/A0A3B5R5A4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM138 family.|||Membrane|||Required for ciliogenesis.|||Vacuole membrane|||cilium http://togogenome.org/gene/8083:mcu ^@ http://purl.uniprot.org/uniprot/A0A3B5PYD3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCU (TC 1.A.77) family.|||Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).|||Membrane|||Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:dbr1 ^@ http://purl.uniprot.org/uniprot/M3ZYP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lariat debranching enzyme family.|||Nucleus http://togogenome.org/gene/8083:LOC102220201 ^@ http://purl.uniprot.org/uniprot/M3ZDG0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/8083:sgcz ^@ http://purl.uniprot.org/uniprot/M3ZWA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/8083:LOC102237562 ^@ http://purl.uniprot.org/uniprot/A0A3B5PY10 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102234512 ^@ http://purl.uniprot.org/uniprot/M3ZIG5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/8083:LOC102234506 ^@ http://purl.uniprot.org/uniprot/M4A4A5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.|||Binds 1 FAD per subunit.|||May have a photoreceptor function. http://togogenome.org/gene/8083:LOC102236818 ^@ http://purl.uniprot.org/uniprot/A0A3B5PY29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:nme9 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q7I7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||Cytoplasm|||Major role in the synthesis of nucleoside triphosphates other than ATP.|||Nucleus|||lamellipodium|||ruffle http://togogenome.org/gene/8083:reep2 ^@ http://purl.uniprot.org/uniprot/A0A3B5R0J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/8083:rpl23a ^@ http://purl.uniprot.org/uniprot/M4A8R6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/8083:LOC102226511 ^@ http://purl.uniprot.org/uniprot/M4A5S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/8083:vps37a ^@ http://purl.uniprot.org/uniprot/M3ZX33 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/8083:fgf7 ^@ http://purl.uniprot.org/uniprot/M3ZJ89 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:LOC102227330 ^@ http://purl.uniprot.org/uniprot/M4AFD1 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/8083:LOC102224638 ^@ http://purl.uniprot.org/uniprot/M4AQR9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||desmosome http://togogenome.org/gene/8083:lin7c ^@ http://purl.uniprot.org/uniprot/M4AV25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-7 family.|||Cell junction|||Cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. http://togogenome.org/gene/8083:LOC102218120 ^@ http://purl.uniprot.org/uniprot/M3ZFX4 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. http://togogenome.org/gene/8083:hoxa5 ^@ http://purl.uniprot.org/uniprot/M3ZFP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/8083:LOC102222266 ^@ http://purl.uniprot.org/uniprot/M3ZF38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/8083:LOC102236741 ^@ http://purl.uniprot.org/uniprot/M3ZV46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/8083:mcee ^@ http://purl.uniprot.org/uniprot/M4AV33 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/8083:hs6st3 ^@ http://purl.uniprot.org/uniprot/M3ZR60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/8083:ap4m1 ^@ http://purl.uniprot.org/uniprot/M3ZX47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal.|||Early endosome|||trans-Golgi network membrane http://togogenome.org/gene/8083:LOC102229060 ^@ http://purl.uniprot.org/uniprot/M4ALK6 ^@ Similarity ^@ Belongs to the pellino family. http://togogenome.org/gene/8083:LOC102232864 ^@ http://purl.uniprot.org/uniprot/M4A783 ^@ Function|||Similarity|||Subunit ^@ Belongs to the casein kinase 2 subunit beta family.|||Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/8083:LOC102224001 ^@ http://purl.uniprot.org/uniprot/A0A3B5QLN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/8083:sulf1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQ51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Cell surface|||Endoplasmic reticulum|||Golgi stack http://togogenome.org/gene/8083:LOC102217618 ^@ http://purl.uniprot.org/uniprot/M4AHV1 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8083:LOC102228542 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q5V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/8083:surf4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QST1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:aph1a ^@ http://purl.uniprot.org/uniprot/M4A5T6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. http://togogenome.org/gene/8083:babam1 ^@ http://purl.uniprot.org/uniprot/M3ZJJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BABAM1 family.|||Nucleus http://togogenome.org/gene/8083:LOC102235995 ^@ http://purl.uniprot.org/uniprot/M3ZUW3 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/8083:LOC102225964 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGQ4 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||RNA-binding protein that regulates alternative splicing events. http://togogenome.org/gene/8083:LOC102232444 ^@ http://purl.uniprot.org/uniprot/M3ZLW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8083:LOC102231613 ^@ http://purl.uniprot.org/uniprot/A0A3B5RCR2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/8083:LOC102236832 ^@ http://purl.uniprot.org/uniprot/M3ZJE0 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. http://togogenome.org/gene/8083:sfxn4 ^@ http://purl.uniprot.org/uniprot/M4A0K2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane http://togogenome.org/gene/8083:paqr5 ^@ http://purl.uniprot.org/uniprot/A0A3B5R046 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/8083:LOC102227924 ^@ http://purl.uniprot.org/uniprot/M4AK49 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/8083:tnfrsf21 ^@ http://purl.uniprot.org/uniprot/M4A3B1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:tspan31 ^@ http://purl.uniprot.org/uniprot/M4A4T7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:LOC102221567 ^@ http://purl.uniprot.org/uniprot/M3ZQF8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/8083:pld1 ^@ http://purl.uniprot.org/uniprot/M4A3X6 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/8083:cmpk2 ^@ http://purl.uniprot.org/uniprot/M4A0N6 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/8083:LOC102225893 ^@ http://purl.uniprot.org/uniprot/M4AHI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/8083:LOC102236605 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHM3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/8083:map3k8 ^@ http://purl.uniprot.org/uniprot/A0A3B5QJG1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/8083:LOC102232223 ^@ http://purl.uniprot.org/uniprot/M4AJN6 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/8083:LOC102217605 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/8083:col4a3bp ^@ http://purl.uniprot.org/uniprot/M3ZXX3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Golgi apparatus http://togogenome.org/gene/8083:LOC102218889 ^@ http://purl.uniprot.org/uniprot/M3ZN16 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/8083:ell2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PPG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Nucleus http://togogenome.org/gene/8083:LOC102236163 ^@ http://purl.uniprot.org/uniprot/A0A3B5R998 ^@ Similarity|||Subunit ^@ Belongs to the 14-3-3 family.|||Homodimer, and heterodimer with other family members. http://togogenome.org/gene/8083:ndufs4 ^@ http://purl.uniprot.org/uniprot/M4A6W9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS4 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:ddb2 ^@ http://purl.uniprot.org/uniprot/M3ZNB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DDB2/WDR76 family.|||Nucleus http://togogenome.org/gene/8083:galt ^@ http://purl.uniprot.org/uniprot/M3ZJ02 ^@ Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. http://togogenome.org/gene/8083:trip13 ^@ http://purl.uniprot.org/uniprot/M4AHZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. PCH2 subfamily.|||Nucleus|||Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. http://togogenome.org/gene/8083:cand1 ^@ http://purl.uniprot.org/uniprot/M3ZWF4 ^@ Similarity ^@ Belongs to the CAND family. http://togogenome.org/gene/8083:LOC102230318 ^@ http://purl.uniprot.org/uniprot/A0A3B5RFI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/8083:eif6 ^@ http://purl.uniprot.org/uniprot/M3ZRD1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-6 family.|||Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.|||Cytoplasm|||Monomer. Associates with the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/8083:eif3l ^@ http://purl.uniprot.org/uniprot/M3ZQW5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit L family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm http://togogenome.org/gene/8083:LOC106699629 ^@ http://purl.uniprot.org/uniprot/M4AWW9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:rhpn2 ^@ http://purl.uniprot.org/uniprot/M4ABX6 ^@ Similarity ^@ Belongs to the RHPN family. http://togogenome.org/gene/8083:LOC102233483 ^@ http://purl.uniprot.org/uniprot/M4A443 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/8083:cavin1 ^@ http://purl.uniprot.org/uniprot/M4A3I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/8083:htra1 ^@ http://purl.uniprot.org/uniprot/M4AIK9 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/8083:LOC102227358 ^@ http://purl.uniprot.org/uniprot/M4AVC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:fmnl2 ^@ http://purl.uniprot.org/uniprot/A0A3B5R4P6 ^@ Similarity ^@ Belongs to the formin homology family. http://togogenome.org/gene/8083:LOC102233352 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q6J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:eif3h ^@ http://purl.uniprot.org/uniprot/M4A2A3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit H family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm http://togogenome.org/gene/8083:LOC102229570 ^@ http://purl.uniprot.org/uniprot/M4AP81 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/8083:pex19 ^@ http://purl.uniprot.org/uniprot/M3ZTB4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxin-19 family.|||Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.|||Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.|||Peroxisome membrane http://togogenome.org/gene/8083:thumpd3 ^@ http://purl.uniprot.org/uniprot/M3ZGS7 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/8083:pfas ^@ http://purl.uniprot.org/uniprot/A0A3B5R4I6 ^@ Similarity ^@ In the N-terminal section; belongs to the FGAMS family. http://togogenome.org/gene/8083:anapc16 ^@ http://purl.uniprot.org/uniprot/M4AKL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC16 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||Cytoplasm|||Nucleus|||kinetochore http://togogenome.org/gene/8083:mcrip2 ^@ http://purl.uniprot.org/uniprot/M3ZYA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCRIP family.|||Nucleus|||Stress granule http://togogenome.org/gene/8083:LOC102228798 ^@ http://purl.uniprot.org/uniprot/M4AMV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/8083:LOC102230447 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWL6 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8083:pigp ^@ http://purl.uniprot.org/uniprot/A0A3B5PRB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGP family.|||Membrane|||Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. http://togogenome.org/gene/8083:LOC102223385 ^@ http://purl.uniprot.org/uniprot/M3ZMK9 ^@ Similarity ^@ Belongs to the lin-28 family. http://togogenome.org/gene/8083:slc25a47 ^@ http://purl.uniprot.org/uniprot/M4AGF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:LOC102219360 ^@ http://purl.uniprot.org/uniprot/M3ZMN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/8083:slain2 ^@ http://purl.uniprot.org/uniprot/A0A3B5R0H6 ^@ Similarity ^@ Belongs to the SLAIN motif-containing family. http://togogenome.org/gene/8083:LOC102233636 ^@ http://purl.uniprot.org/uniprot/M4ADQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:ddx1 ^@ http://purl.uniprot.org/uniprot/M3ZQW1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DDX1 subfamily.|||Cytoplasmic granule|||RNA helicase.|||The helicase domain is involved in the stimulation of RELA transcriptional activity. http://togogenome.org/gene/8083:pip4p1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QMP4 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/8083:LOC102237225 ^@ http://purl.uniprot.org/uniprot/M4AZB0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:agtrap ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9L4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102226716 ^@ http://purl.uniprot.org/uniprot/M3ZUQ8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:LOC102226660 ^@ http://purl.uniprot.org/uniprot/M3ZJM0 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8083:LOC102226016 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDL1 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/8083:svop ^@ http://purl.uniprot.org/uniprot/M4AUY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/8083:LOC102226857 ^@ http://purl.uniprot.org/uniprot/A0A3B5QYY5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/8083:cav3 ^@ http://purl.uniprot.org/uniprot/M3ZH35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/8083:ggt7 ^@ http://purl.uniprot.org/uniprot/M4ALJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyltransferase family.|||Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.|||Membrane http://togogenome.org/gene/8083:LOC102216384 ^@ http://purl.uniprot.org/uniprot/M4A1C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102237203 ^@ http://purl.uniprot.org/uniprot/M4AI76 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:myorg ^@ http://purl.uniprot.org/uniprot/M4AUT2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/8083:LOC102228547 ^@ http://purl.uniprot.org/uniprot/M4A1T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/8083:march11 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAB8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:atg13 ^@ http://purl.uniprot.org/uniprot/A0A3B5QY85|||http://purl.uniprot.org/uniprot/M3ZQ74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG13 family. Metazoan subfamily.|||Preautophagosomal structure http://togogenome.org/gene/8083:rrh ^@ http://purl.uniprot.org/uniprot/M4ALW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/8083:rragc ^@ http://purl.uniprot.org/uniprot/A0A3B5QHR8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/8083:maf1 ^@ http://purl.uniprot.org/uniprot/M3ZJB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAF1 family.|||Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.|||Nucleus http://togogenome.org/gene/8083:LOC102234352 ^@ http://purl.uniprot.org/uniprot/M3ZHC5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Heterodimer; with an rxr molecule. Binds DNA preferentially as a rar/rxr heterodimer.|||Nucleus http://togogenome.org/gene/8083:LOC102229141 ^@ http://purl.uniprot.org/uniprot/M3ZGE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/8083:rps27a ^@ http://purl.uniprot.org/uniprot/M3ZD74 ^@ Similarity ^@ In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family. http://togogenome.org/gene/8083:LOC102218115 ^@ http://purl.uniprot.org/uniprot/M4A1I8 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/8083:tfb1m ^@ http://purl.uniprot.org/uniprot/M4AXR9 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/8083:LOC102225382 ^@ http://purl.uniprot.org/uniprot/M3ZM53 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/8083:fzd6 ^@ http://purl.uniprot.org/uniprot/M3ZPA7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:prpf38a ^@ http://purl.uniprot.org/uniprot/A0A3B5PZC3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRP38 family.|||Component of the spliceosome B complex.|||Involved in pre-mRNA splicing as a component of the spliceosome.|||Nucleus http://togogenome.org/gene/8083:ddr1 ^@ http://purl.uniprot.org/uniprot/M4A992 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102218549 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1N3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neuregulin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/8083:LOC102234697 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZX8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:dpagt1 ^@ http://purl.uniprot.org/uniprot/M3ZUT6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family.|||Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:jam3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QBI0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:glce ^@ http://purl.uniprot.org/uniprot/A0A3B5RCD5 ^@ Similarity ^@ Belongs to the D-glucuronyl C5-epimerase family. http://togogenome.org/gene/8083:LOC102226711 ^@ http://purl.uniprot.org/uniprot/M4A4Q8 ^@ Similarity ^@ Belongs to the SLAIN motif-containing family. http://togogenome.org/gene/8083:ctnna1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QLL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||adherens junction http://togogenome.org/gene/8083:dll4 ^@ http://purl.uniprot.org/uniprot/M3ZPW8 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/8083:cln8 ^@ http://purl.uniprot.org/uniprot/A0A3B5QP03 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102227170 ^@ http://purl.uniprot.org/uniprot/M4A1I2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:ctnnbip1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHN9 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/8083:LOC102238301 ^@ http://purl.uniprot.org/uniprot/M4AYQ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102222149 ^@ http://purl.uniprot.org/uniprot/M4AZL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.|||Membrane http://togogenome.org/gene/8083:LOC102235522 ^@ http://purl.uniprot.org/uniprot/M3ZST7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102222210 ^@ http://purl.uniprot.org/uniprot/M4A7L3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. http://togogenome.org/gene/8083:bccip ^@ http://purl.uniprot.org/uniprot/A0A3B5R1D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BCP1 family.|||spindle pole http://togogenome.org/gene/8083:LOC106699616 ^@ http://purl.uniprot.org/uniprot/M4ABU5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102222833 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q6G7 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/8083:LOC102233460 ^@ http://purl.uniprot.org/uniprot/A0A3B5R0V3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Nematocyst|||Target cell membrane http://togogenome.org/gene/8083:LOC102229142 ^@ http://purl.uniprot.org/uniprot/M3ZI41 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/8083:phb ^@ http://purl.uniprot.org/uniprot/M4A261 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Cell membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102228356 ^@ http://purl.uniprot.org/uniprot/M3ZU94 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/8083:LOC102233741 ^@ http://purl.uniprot.org/uniprot/A0A3B5R0L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cytoplasm http://togogenome.org/gene/8083:spock2 ^@ http://purl.uniprot.org/uniprot/M4AKR5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:vti1a ^@ http://purl.uniprot.org/uniprot/A0A3B5PTX5|||http://purl.uniprot.org/uniprot/A0A3B5R294 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/8083:xpnpep2 ^@ http://purl.uniprot.org/uniprot/M4AGL3 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/8083:gcdh ^@ http://purl.uniprot.org/uniprot/M4AB06 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/8083:rbm5 ^@ http://purl.uniprot.org/uniprot/M4APP9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102219772 ^@ http://purl.uniprot.org/uniprot/M4AHR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/8083:hlcs ^@ http://purl.uniprot.org/uniprot/M4A4V2 ^@ Similarity ^@ Belongs to the biotin--protein ligase family. http://togogenome.org/gene/8083:akirin1 ^@ http://purl.uniprot.org/uniprot/M4AFL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/8083:cops6 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q6X3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN6 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102236718 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q6M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:cldn19 ^@ http://purl.uniprot.org/uniprot/M3ZK56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/8083:nr2f2 ^@ http://purl.uniprot.org/uniprot/M4AI36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/8083:LOC102238285 ^@ http://purl.uniprot.org/uniprot/A0A3B5QCW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Nucleus http://togogenome.org/gene/8083:LOC102230974 ^@ http://purl.uniprot.org/uniprot/M3ZHZ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:dap3 ^@ http://purl.uniprot.org/uniprot/M4AP12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS29 family.|||Mitochondrion http://togogenome.org/gene/8083:clmp ^@ http://purl.uniprot.org/uniprot/A0A3B5PQZ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102223460 ^@ http://purl.uniprot.org/uniprot/M4AVA0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/8083:LOC102234122 ^@ http://purl.uniprot.org/uniprot/M3ZX03 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:dus4l ^@ http://purl.uniprot.org/uniprot/M4A1Y1 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. http://togogenome.org/gene/8083:clrn3 ^@ http://purl.uniprot.org/uniprot/M4APG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/8083:LOC102226303 ^@ http://purl.uniprot.org/uniprot/A0A3B5QL00 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8083:hdhd3 ^@ http://purl.uniprot.org/uniprot/M4AM20 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/8083:LOC102235730 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q4W0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/8083:ccdc58 ^@ http://purl.uniprot.org/uniprot/A0A3B5R526 ^@ Similarity ^@ Belongs to the MIX23 family. http://togogenome.org/gene/8083:anapc4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQJ7 ^@ Function|||Similarity ^@ Belongs to the APC4 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/8083:cltrn ^@ http://purl.uniprot.org/uniprot/M4ASW9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:hoxa9 ^@ http://purl.uniprot.org/uniprot/M3ZFQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/8083:ccdc149 ^@ http://purl.uniprot.org/uniprot/M4A1W7 ^@ Similarity ^@ Belongs to the CCDC149 family. http://togogenome.org/gene/8083:kirrel1 ^@ http://purl.uniprot.org/uniprot/M4AAZ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:aga ^@ http://purl.uniprot.org/uniprot/A0A3B5PQC9 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/8083:mfap3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QYB9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102238135 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1T1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102228344 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7R4 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/8083:frg1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PX65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FRG1 family.|||Cajal body|||nucleolus http://togogenome.org/gene/8083:LOC102220928 ^@ http://purl.uniprot.org/uniprot/M4AY06 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:rtcb ^@ http://purl.uniprot.org/uniprot/M3ZKX4 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Catalytic component of the tRNA-splicing ligase complex.|||Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.|||Cytoplasm|||Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP. http://togogenome.org/gene/8083:ndfip2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PYN6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102233374 ^@ http://purl.uniprot.org/uniprot/A0A3B5R3A1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/8083:lclat1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q7H5 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/8083:gnrh2 ^@ http://purl.uniprot.org/uniprot/M3ZIT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GnRH family.|||Secreted|||Stimulates the secretion of gonadotropins. http://togogenome.org/gene/8083:LOC102230138 ^@ http://purl.uniprot.org/uniprot/M3ZU26 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102220374 ^@ http://purl.uniprot.org/uniprot/M4AN21 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/8083:LOC102229356 ^@ http://purl.uniprot.org/uniprot/M3ZHJ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer. http://togogenome.org/gene/8083:tbp ^@ http://purl.uniprot.org/uniprot/M4AKH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/8083:tlr3 ^@ http://purl.uniprot.org/uniprot/M4AWR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/8083:ace2 ^@ http://purl.uniprot.org/uniprot/M3ZIE3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M2 family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Cytoplasm|||Membrane|||Secreted|||cilium http://togogenome.org/gene/8083:nploc4 ^@ http://purl.uniprot.org/uniprot/M4AJF3 ^@ Similarity ^@ Belongs to the NPL4 family. http://togogenome.org/gene/8083:mturn ^@ http://purl.uniprot.org/uniprot/M3ZE04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MTURN family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102222798 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q412 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:tmed10 ^@ http://purl.uniprot.org/uniprot/A0A3B5QC36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102223982 ^@ http://purl.uniprot.org/uniprot/M4AXK9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/8083:dhrs3 ^@ http://purl.uniprot.org/uniprot/A0A3B5R9S2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:c8h18orf25 ^@ http://purl.uniprot.org/uniprot/M3ZSC3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:dyrk2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVF5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/8083:LOC102228515 ^@ http://purl.uniprot.org/uniprot/A0A3B5R617 ^@ Similarity ^@ Belongs to the neuritin family. http://togogenome.org/gene/8083:cilp2 ^@ http://purl.uniprot.org/uniprot/M4AD27 ^@ Subcellular Location Annotation ^@ Membrane|||extracellular matrix http://togogenome.org/gene/8083:gcg ^@ http://purl.uniprot.org/uniprot/A0A3B5R6F5 ^@ Similarity ^@ Belongs to the glucagon family. http://togogenome.org/gene/8083:c11h21orf59 ^@ http://purl.uniprot.org/uniprot/M4AT18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP298 family.|||cilium basal body http://togogenome.org/gene/8083:nifk ^@ http://purl.uniprot.org/uniprot/A0A3B5QW40 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/8083:psme3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QVU4 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/8083:LOC102226787 ^@ http://purl.uniprot.org/uniprot/M4A1D2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.|||Membrane http://togogenome.org/gene/8083:LOC102218352 ^@ http://purl.uniprot.org/uniprot/M4AAT7 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. http://togogenome.org/gene/8083:LOC102223055 ^@ http://purl.uniprot.org/uniprot/A0A3B5PX32 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Nucleus|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/8083:LOC102220632 ^@ http://purl.uniprot.org/uniprot/A0A3B5R1D8|||http://purl.uniprot.org/uniprot/M3ZGY7 ^@ Similarity ^@ Belongs to the RUTBC family. http://togogenome.org/gene/8083:ccna2 ^@ http://purl.uniprot.org/uniprot/M3ZIL8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. http://togogenome.org/gene/8083:LOC102236661 ^@ http://purl.uniprot.org/uniprot/A0A3B5PRA4 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/8083:castor2 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0J9 ^@ Similarity ^@ Belongs to the GATS family. http://togogenome.org/gene/8083:LOC102231032 ^@ http://purl.uniprot.org/uniprot/M3ZSM9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102228911 ^@ http://purl.uniprot.org/uniprot/A0A3B5PP42 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/8083:fam199x ^@ http://purl.uniprot.org/uniprot/M4AMV2 ^@ Similarity ^@ Belongs to the FAM199 family. http://togogenome.org/gene/8083:sec24c ^@ http://purl.uniprot.org/uniprot/A0A3B5QRQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/8083:ptgr1 ^@ http://purl.uniprot.org/uniprot/M3ZHQ4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer or homodimer. http://togogenome.org/gene/8083:wdfy1 ^@ http://purl.uniprot.org/uniprot/M4A1B8 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/8083:aox1 ^@ http://purl.uniprot.org/uniprot/M1ZMQ9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Peroxisome http://togogenome.org/gene/8083:hnrnpd ^@ http://purl.uniprot.org/uniprot/M4AXK2 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/8083:fyttd1 ^@ http://purl.uniprot.org/uniprot/M3ZRD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UIF family.|||Nucleus speckle|||nucleoplasm http://togogenome.org/gene/8083:sfrp1 ^@ http://purl.uniprot.org/uniprot/M4A7P1 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:kif1bp ^@ http://purl.uniprot.org/uniprot/M4AJA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KIF-binding protein family.|||cytoskeleton http://togogenome.org/gene/8083:ebp ^@ http://purl.uniprot.org/uniprot/M4A0Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102228244 ^@ http://purl.uniprot.org/uniprot/M3ZMI2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:march9 ^@ http://purl.uniprot.org/uniprot/M4A4R0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:ndufa2 ^@ http://purl.uniprot.org/uniprot/M3ZWB2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:tmem38b ^@ http://purl.uniprot.org/uniprot/M4AAB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/8083:gpx7 ^@ http://purl.uniprot.org/uniprot/M3ZEW9 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/8083:scrn2 ^@ http://purl.uniprot.org/uniprot/M4AUJ5 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/8083:LOC102226263 ^@ http://purl.uniprot.org/uniprot/M4AA07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted|||Somatostatin inhibits the release of somatotropin. http://togogenome.org/gene/8083:LOC102237316 ^@ http://purl.uniprot.org/uniprot/M4ANK9 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/8083:igfbp4 ^@ http://purl.uniprot.org/uniprot/M4AUR8 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds IGF2 more than IGF1.|||IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:neurod1 ^@ http://purl.uniprot.org/uniprot/M3ZH15 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102229180 ^@ http://purl.uniprot.org/uniprot/M4ALF1 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Contains one covalently linked retinal chromophore.|||Membrane http://togogenome.org/gene/8083:ppil1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q7H0 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/8083:actr5 ^@ http://purl.uniprot.org/uniprot/M4AXA1 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/8083:ptgr2 ^@ http://purl.uniprot.org/uniprot/M4AN41 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/8083:abhd3 ^@ http://purl.uniprot.org/uniprot/M3ZUP4 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/8083:uba2 ^@ http://purl.uniprot.org/uniprot/M4ANU4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ubiquitin-activating E1 family.|||Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.|||Nucleus|||The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. http://togogenome.org/gene/8083:mrpl54 ^@ http://purl.uniprot.org/uniprot/M3ZMQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL54 family.|||Mitochondrion http://togogenome.org/gene/8083:evc ^@ http://purl.uniprot.org/uniprot/A0A3B5R461 ^@ Subcellular Location Annotation ^@ Membrane|||cilium basal body|||cilium membrane http://togogenome.org/gene/8083:LOC102230627 ^@ http://purl.uniprot.org/uniprot/M3ZSX7 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/8083:LOC102230643 ^@ http://purl.uniprot.org/uniprot/M4A4Z9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:LOC102236786 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWU2|||http://purl.uniprot.org/uniprot/M4A3T9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102232394 ^@ http://purl.uniprot.org/uniprot/M4B144 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:eif3i ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0R7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit I family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm http://togogenome.org/gene/8083:foxa2 ^@ http://purl.uniprot.org/uniprot/M4AP91 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102229373 ^@ http://purl.uniprot.org/uniprot/A0A3B5QC47 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:LOC102238426 ^@ http://purl.uniprot.org/uniprot/M3ZE60 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8083:LOC102238331 ^@ http://purl.uniprot.org/uniprot/A0A3B5R0K9 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/8083:LOC102227793 ^@ http://purl.uniprot.org/uniprot/M4A8M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/8083:LOC102228006 ^@ http://purl.uniprot.org/uniprot/A0A3B5QE86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102222071 ^@ http://purl.uniprot.org/uniprot/M4AKI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel HCN family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102230189 ^@ http://purl.uniprot.org/uniprot/A0A3B5QBF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM198 family.|||Membrane http://togogenome.org/gene/8083:rundc3b ^@ http://purl.uniprot.org/uniprot/A0A3B5QYI7 ^@ Similarity ^@ Belongs to the RUNDC3 family. http://togogenome.org/gene/8083:LOC102221736 ^@ http://purl.uniprot.org/uniprot/M3ZHK7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:ebpl ^@ http://purl.uniprot.org/uniprot/A0A3B5R778 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:trap1 ^@ http://purl.uniprot.org/uniprot/M3ZQR2 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/8083:uba6 ^@ http://purl.uniprot.org/uniprot/M4ADR7 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/8083:LOC102233876 ^@ http://purl.uniprot.org/uniprot/M4A1L6 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/8083:l3mbtl3 ^@ http://purl.uniprot.org/uniprot/M4AF60 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:ssr3 ^@ http://purl.uniprot.org/uniprot/M4ART2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-gamma family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/8083:LOC102220649 ^@ http://purl.uniprot.org/uniprot/M4AYD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF2BP family.|||Nucleus http://togogenome.org/gene/8083:nsmce1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQD3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE1 family.|||Component of the Smc5-Smc6 complex.|||Nucleus|||RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.|||telomere http://togogenome.org/gene/8083:LOC102232604 ^@ http://purl.uniprot.org/uniprot/M4A781 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/8083:fbl ^@ http://purl.uniprot.org/uniprot/M4A254 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Fibrillarin family. http://togogenome.org/gene/8083:mrpl44 ^@ http://purl.uniprot.org/uniprot/M4A8L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.|||Mitochondrion http://togogenome.org/gene/8083:LOC102219006 ^@ http://purl.uniprot.org/uniprot/M4AZ88 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:LOC102227640 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3V1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/8083:mab21l2 ^@ http://purl.uniprot.org/uniprot/M4AZE6 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/8083:cd44 ^@ http://purl.uniprot.org/uniprot/A0A3B5QB56 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||microvillus http://togogenome.org/gene/8083:LOC102228996 ^@ http://purl.uniprot.org/uniprot/M3ZWQ6 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:smad3 ^@ http://purl.uniprot.org/uniprot/M3ZMX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102216651 ^@ http://purl.uniprot.org/uniprot/A0A3B5PR13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/8083:ptch2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QTI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/8083:LOC102233953 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q5L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF2BP family.|||Nucleus http://togogenome.org/gene/8083:skap2 ^@ http://purl.uniprot.org/uniprot/M4AHJ5 ^@ Similarity ^@ Belongs to the SKAP family. http://togogenome.org/gene/8083:timm23 ^@ http://purl.uniprot.org/uniprot/M4ARI0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102231259 ^@ http://purl.uniprot.org/uniprot/M3ZWD3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:adsl ^@ http://purl.uniprot.org/uniprot/M3ZKC4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/8083:slc43a1 ^@ http://purl.uniprot.org/uniprot/M4A5W8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102231585 ^@ http://purl.uniprot.org/uniprot/M3ZQ15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cleavage furrow|||Midbody|||cilium membrane|||spindle http://togogenome.org/gene/8083:mid2 ^@ http://purl.uniprot.org/uniprot/A0A3B5RC52 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/8083:hdgfl2 ^@ http://purl.uniprot.org/uniprot/M3ZMS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HDGF family.|||Nucleus http://togogenome.org/gene/8083:LOC102237653 ^@ http://purl.uniprot.org/uniprot/M3ZWX8 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/8083:hmgb2 ^@ http://purl.uniprot.org/uniprot/M4ACV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/8083:LOC102223075 ^@ http://purl.uniprot.org/uniprot/M3ZH61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/8083:LOC102224250 ^@ http://purl.uniprot.org/uniprot/M4A5T7 ^@ Similarity ^@ Belongs to the requiem/DPF family. http://togogenome.org/gene/8083:LOC102221853 ^@ http://purl.uniprot.org/uniprot/A0A3B5QLD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM138 family.|||Membrane|||Required for ciliogenesis.|||Vacuole membrane|||cilium http://togogenome.org/gene/8083:LOC102218848 ^@ http://purl.uniprot.org/uniprot/A0A3B5PTJ6 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/8083:LOC102235650 ^@ http://purl.uniprot.org/uniprot/M4A678 ^@ Similarity ^@ Belongs to the GST superfamily. Mu family. http://togogenome.org/gene/8083:cachd1 ^@ http://purl.uniprot.org/uniprot/A0A3B5RF01 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/8083:chst14 ^@ http://purl.uniprot.org/uniprot/A0A3B5PW15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:gch1 ^@ http://purl.uniprot.org/uniprot/M4A5Y3 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I family. http://togogenome.org/gene/8083:LOC102235837 ^@ http://purl.uniprot.org/uniprot/M4AHK2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:LOC102219492 ^@ http://purl.uniprot.org/uniprot/M4ADV8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:nt5dc2 ^@ http://purl.uniprot.org/uniprot/M4ANV0 ^@ Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family. http://togogenome.org/gene/8083:LOC102233227 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQ30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/8083:fam219b ^@ http://purl.uniprot.org/uniprot/M4AQU8 ^@ Similarity ^@ Belongs to the FAM219 family. http://togogenome.org/gene/8083:LOC102228562 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZZ5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:hcn1 ^@ http://purl.uniprot.org/uniprot/M3ZQD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel HCN family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102232433 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAJ5 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/8083:LOC102230800 ^@ http://purl.uniprot.org/uniprot/M4A092 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM163 family.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/8083:smg6 ^@ http://purl.uniprot.org/uniprot/M4A799 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini.|||Plays a role in nonsense-mediated mRNA decay.|||The PINc domain confers endonuclease activity and is expected to bind the catalytic metal ion.|||cytosol|||nucleolus|||telomere http://togogenome.org/gene/8083:LOC102219333 ^@ http://purl.uniprot.org/uniprot/M4AU03 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/8083:LOC102235235 ^@ http://purl.uniprot.org/uniprot/M3ZWT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/8083:LOC102224886 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0J1 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/8083:sdha ^@ http://purl.uniprot.org/uniprot/M4A3A0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.|||Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/8083:masp2 ^@ http://purl.uniprot.org/uniprot/M4AA08 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102224167 ^@ http://purl.uniprot.org/uniprot/M3ZQ49 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/8083:bloc1s6 ^@ http://purl.uniprot.org/uniprot/M3ZJC1 ^@ Function|||Similarity ^@ Belongs to the BLOC1S6 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. http://togogenome.org/gene/8083:psma4 ^@ http://purl.uniprot.org/uniprot/M4A9H3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Belongs to the peptidase T1B family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:oxtr ^@ http://purl.uniprot.org/uniprot/M3ZH30 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102230394 ^@ http://purl.uniprot.org/uniprot/M4ARV6 ^@ Similarity|||Subunit ^@ Belongs to the 14-3-3 family.|||Homodimer, and heterodimer with other family members. http://togogenome.org/gene/8083:phox2b ^@ http://purl.uniprot.org/uniprot/A0A3B5Q688 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:iapp ^@ http://purl.uniprot.org/uniprot/A0A3B5QTJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcitonin family.|||Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.|||Secreted http://togogenome.org/gene/8083:rhbdd1 ^@ http://purl.uniprot.org/uniprot/M4AFJ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102232953 ^@ http://purl.uniprot.org/uniprot/A0A3B5PRE8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102217502 ^@ http://purl.uniprot.org/uniprot/M3ZKU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Nucleus http://togogenome.org/gene/8083:a1cf ^@ http://purl.uniprot.org/uniprot/M4AQK5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:nipal2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/8083:eif4a3 ^@ http://purl.uniprot.org/uniprot/M4AI55 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/8083:pdgfrl ^@ http://purl.uniprot.org/uniprot/M4ASU6 ^@ Subunit ^@ Forms a complex composed of PDGFRL, TNK2 and GRB2. http://togogenome.org/gene/8083:nkiras2 ^@ http://purl.uniprot.org/uniprot/M4A356 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/8083:LOC102234974 ^@ http://purl.uniprot.org/uniprot/M3ZD64 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/8083:ube2k ^@ http://purl.uniprot.org/uniprot/A0A3B5QHR2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:ccnj ^@ http://purl.uniprot.org/uniprot/M3ZZK0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. http://togogenome.org/gene/8083:LOC102235665 ^@ http://purl.uniprot.org/uniprot/M4ATL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/8083:LOC102222613 ^@ http://purl.uniprot.org/uniprot/M3ZMH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/8083:nxph4 ^@ http://purl.uniprot.org/uniprot/M3ZVC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/8083:oprd1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R6W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102217026 ^@ http://purl.uniprot.org/uniprot/M3ZN28 ^@ Similarity ^@ Belongs to the neuritin family. http://togogenome.org/gene/8083:KEG86_p04 ^@ http://purl.uniprot.org/uniprot/B5WZ60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/8083:tp53 ^@ http://purl.uniprot.org/uniprot/Q92143 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity).|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102231053 ^@ http://purl.uniprot.org/uniprot/M4A8V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane http://togogenome.org/gene/8083:pigw ^@ http://purl.uniprot.org/uniprot/M4B015 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGW family.|||Endoplasmic reticulum membrane|||Membrane|||Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. http://togogenome.org/gene/8083:LOC102217268 ^@ http://purl.uniprot.org/uniprot/A0A3B5R9N1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:cdc42se1 ^@ http://purl.uniprot.org/uniprot/M4ASC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/8083:LOC102221121 ^@ http://purl.uniprot.org/uniprot/M4A988 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/8083:LOC102237202 ^@ http://purl.uniprot.org/uniprot/M4AWQ3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:LOC102225993 ^@ http://purl.uniprot.org/uniprot/M3ZGC2 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/8083:lypla1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QMY8 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/8083:tomm6 ^@ http://purl.uniprot.org/uniprot/M4AZQ9 ^@ Similarity ^@ Belongs to the UPF0739 family. http://togogenome.org/gene/8083:banf1 ^@ http://purl.uniprot.org/uniprot/M3ZSC6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102221109 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUA1 ^@ Similarity ^@ Belongs to the ependymin family. http://togogenome.org/gene/8083:LOC102219884 ^@ http://purl.uniprot.org/uniprot/M4AB11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM198 family.|||Membrane http://togogenome.org/gene/8083:pcsk2 ^@ http://purl.uniprot.org/uniprot/M4A863 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/8083:tlx3 ^@ http://purl.uniprot.org/uniprot/M4AAF1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102220680 ^@ http://purl.uniprot.org/uniprot/M4AMM8 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homo- and heterotetramers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:gtpbp10 ^@ http://purl.uniprot.org/uniprot/M3ZXI4 ^@ Similarity ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. http://togogenome.org/gene/8083:LOC102227910 ^@ http://purl.uniprot.org/uniprot/M3ZVI0 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/8083:LOC102221189 ^@ http://purl.uniprot.org/uniprot/M4AZV1 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/8083:LOC102230474 ^@ http://purl.uniprot.org/uniprot/M4ATB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/8083:LOC102220871 ^@ http://purl.uniprot.org/uniprot/M4AMZ6 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/8083:supt4h1 ^@ http://purl.uniprot.org/uniprot/M3ZTV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT4 family.|||Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.|||Nucleus http://togogenome.org/gene/8083:cep44 ^@ http://purl.uniprot.org/uniprot/M4ASX5 ^@ Subcellular Location Annotation ^@ Midbody|||centriole|||spindle pole http://togogenome.org/gene/8083:smim12 ^@ http://purl.uniprot.org/uniprot/M4AYG9 ^@ Similarity ^@ Belongs to the SMIM12 family. http://togogenome.org/gene/8083:cse1l ^@ http://purl.uniprot.org/uniprot/A0A3B5PVW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPO2/CSE1 family.|||Cytoplasm http://togogenome.org/gene/8083:ncapg ^@ http://purl.uniprot.org/uniprot/M4A5V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND3 (condensin subunit 3) family.|||Chromosome http://togogenome.org/gene/8083:LOC102225797 ^@ http://purl.uniprot.org/uniprot/M3ZVM8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102228370 ^@ http://purl.uniprot.org/uniprot/M4AW33 ^@ Function|||Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. http://togogenome.org/gene/8083:atp6v1f ^@ http://purl.uniprot.org/uniprot/M4ALJ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase F subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/8083:intu ^@ http://purl.uniprot.org/uniprot/M3ZI37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inturned family.|||Cell surface|||cilium basal body http://togogenome.org/gene/8083:sf3b5 ^@ http://purl.uniprot.org/uniprot/M4AZX3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SF3B5 family.|||Component of the spliceosome B complex.|||Nucleus http://togogenome.org/gene/8083:LOC102217053 ^@ http://purl.uniprot.org/uniprot/M3ZCV3 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/8083:LOC102231438 ^@ http://purl.uniprot.org/uniprot/A0A3B5PWC7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:rasgrp2 ^@ http://purl.uniprot.org/uniprot/M4AAQ4 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/8083:mrps18c ^@ http://purl.uniprot.org/uniprot/M4ADM9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS18 family. http://togogenome.org/gene/8083:vsig10 ^@ http://purl.uniprot.org/uniprot/M3ZK47 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:actn4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QDG3 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/8083:tubgcp2 ^@ http://purl.uniprot.org/uniprot/M4AJU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/8083:LOC102237945 ^@ http://purl.uniprot.org/uniprot/A0A3B5R151 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/8083:hs3st6 ^@ http://purl.uniprot.org/uniprot/M4AKL1 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/8083:ndufa8 ^@ http://purl.uniprot.org/uniprot/M3ZMX5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA8 subunit family.|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/8083:LOC102220543 ^@ http://purl.uniprot.org/uniprot/M3ZTN7 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/8083:casp7 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q5E6 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/8083:tbxa2r ^@ http://purl.uniprot.org/uniprot/A0A3B5QC85 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:tle1 ^@ http://purl.uniprot.org/uniprot/M4ALC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/8083:gpt ^@ http://purl.uniprot.org/uniprot/A0A3B5PXV9 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/8083:LOC102237334 ^@ http://purl.uniprot.org/uniprot/M4AY01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Membrane http://togogenome.org/gene/8083:tmem98 ^@ http://purl.uniprot.org/uniprot/M4A1K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM98 family.|||Endoplasmic reticulum membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/8083:LOC102238035 ^@ http://purl.uniprot.org/uniprot/M4ALG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/8083:mdfic ^@ http://purl.uniprot.org/uniprot/A0A3B5QCC2 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/8083:plk2 ^@ http://purl.uniprot.org/uniprot/M4AM63 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/8083:LOC102218734 ^@ http://purl.uniprot.org/uniprot/M4AHI2 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/8083:LOC102225403 ^@ http://purl.uniprot.org/uniprot/M3ZSI2 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:LOC102229411 ^@ http://purl.uniprot.org/uniprot/M3ZKA2 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/8083:LOC102229779 ^@ http://purl.uniprot.org/uniprot/A0A3B5QD06 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:hacd2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWV1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102224213 ^@ http://purl.uniprot.org/uniprot/A0A3B5PYQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:LOC102238355 ^@ http://purl.uniprot.org/uniprot/M3ZIC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Endosome membrane|||Membrane|||lamellipodium http://togogenome.org/gene/8083:ndufv2 ^@ http://purl.uniprot.org/uniprot/M3ZF50 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. http://togogenome.org/gene/8083:LOC102235991 ^@ http://purl.uniprot.org/uniprot/M3ZXQ2 ^@ Similarity ^@ Belongs to the FMO family. http://togogenome.org/gene/8083:LOC102218533 ^@ http://purl.uniprot.org/uniprot/A0A3B5PZG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/8083:LOC102235754 ^@ http://purl.uniprot.org/uniprot/M3ZMN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/8083:cers6 ^@ http://purl.uniprot.org/uniprot/M4ABJ1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/8083:eci1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QMC3 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/8083:comt ^@ http://purl.uniprot.org/uniprot/M3ZTR1 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/8083:LOC102237923 ^@ http://purl.uniprot.org/uniprot/M4AMK9 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/8083:LOC102218389 ^@ http://purl.uniprot.org/uniprot/M3ZG96 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/8083:LOC102234937 ^@ http://purl.uniprot.org/uniprot/M3ZUR8 ^@ Similarity ^@ Belongs to the pellino family. http://togogenome.org/gene/8083:LOC102236447 ^@ http://purl.uniprot.org/uniprot/M4AYW4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SOSS-C family.|||Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).|||Component of the SOSS complex.|||Nucleus http://togogenome.org/gene/8083:LOC102221461 ^@ http://purl.uniprot.org/uniprot/M4ABM1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/8083:pde8b ^@ http://purl.uniprot.org/uniprot/M4AWT9 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/8083:ptpn2 ^@ http://purl.uniprot.org/uniprot/M3ZK65 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. http://togogenome.org/gene/8083:LOC102223029 ^@ http://purl.uniprot.org/uniprot/A0A3B5R6D5 ^@ Similarity ^@ Belongs to the spectrin family. http://togogenome.org/gene/8083:nxt2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PV07 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/8083:lyz ^@ http://purl.uniprot.org/uniprot/M4AC10 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/8083:spcs2 ^@ http://purl.uniprot.org/uniprot/M4AIG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS2 family.|||Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102236643 ^@ http://purl.uniprot.org/uniprot/M4AX86 ^@ Function|||Similarity|||Subunit ^@ Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.|||Belongs to the fucolectin family.|||Homotrimer. http://togogenome.org/gene/8083:LOC102230230 ^@ http://purl.uniprot.org/uniprot/M4AGV2 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/8083:LOC102230528 ^@ http://purl.uniprot.org/uniprot/M4A7Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/8083:htr6 ^@ http://purl.uniprot.org/uniprot/M3ZXK3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:LOC102229533 ^@ http://purl.uniprot.org/uniprot/M3ZDL1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/8083:nt5dc3 ^@ http://purl.uniprot.org/uniprot/M4APY8 ^@ Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family. http://togogenome.org/gene/8083:tfpi2 ^@ http://purl.uniprot.org/uniprot/M3ZEN9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/8083:LOC102221441 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q5W7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102221357 ^@ http://purl.uniprot.org/uniprot/M4AQG6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:dkk2 ^@ http://purl.uniprot.org/uniprot/M4A726 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/8083:tbl3 ^@ http://purl.uniprot.org/uniprot/A0A3B5R0I1 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/8083:ttc36 ^@ http://purl.uniprot.org/uniprot/M3ZZI2 ^@ Similarity ^@ Belongs to the TTC36 family. http://togogenome.org/gene/8083:wee1 ^@ http://purl.uniprot.org/uniprot/M4AEC8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.|||Binds 2 magnesium ions per subunit.|||Nucleus http://togogenome.org/gene/8083:mut ^@ http://purl.uniprot.org/uniprot/M3ZMJ3 ^@ Function|||Similarity ^@ Belongs to the methylmalonyl-CoA mutase family.|||Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. http://togogenome.org/gene/8083:naaladl1 ^@ http://purl.uniprot.org/uniprot/M3ZL61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102223888 ^@ http://purl.uniprot.org/uniprot/M3ZQS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/8083:slc35d2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QY30 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:rps15 ^@ http://purl.uniprot.org/uniprot/P70066 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uS19 family.|||Component of the small ribosomal subunit.|||Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm http://togogenome.org/gene/8083:LOC102233346 ^@ http://purl.uniprot.org/uniprot/M3ZY62 ^@ Similarity ^@ Belongs to the nucleobindin family. http://togogenome.org/gene/8083:polr2h ^@ http://purl.uniprot.org/uniprot/M3ZUJ2 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RPB8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/8083:LOC102233024 ^@ http://purl.uniprot.org/uniprot/A0A3B5R5N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 3 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:cdk5 ^@ http://purl.uniprot.org/uniprot/M4AWM2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:LOC106700180 ^@ http://purl.uniprot.org/uniprot/M4B0T4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:mras ^@ http://purl.uniprot.org/uniprot/M3ZIC6 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/8083:LOC102223325 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q2I3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/8083:golm1 ^@ http://purl.uniprot.org/uniprot/M4AR08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLM family.|||Membrane http://togogenome.org/gene/8083:LOC102222505 ^@ http://purl.uniprot.org/uniprot/M3ZUB2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:mfap2 ^@ http://purl.uniprot.org/uniprot/M4AQG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MFAP family.|||extracellular matrix http://togogenome.org/gene/8083:LOC102237794 ^@ http://purl.uniprot.org/uniprot/M3ZSE5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/8083:nrp2 ^@ http://purl.uniprot.org/uniprot/M4ADS4 ^@ Caution|||Similarity ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102232731 ^@ http://purl.uniprot.org/uniprot/M3ZMG5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102236062 ^@ http://purl.uniprot.org/uniprot/M4AQ22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/8083:LOC102219238 ^@ http://purl.uniprot.org/uniprot/M4AC95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/8083:ddx3x ^@ http://purl.uniprot.org/uniprot/A0A3B5Q614 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/8083:marcks ^@ http://purl.uniprot.org/uniprot/M3ZSL1 ^@ Similarity ^@ Belongs to the MARCKS family. http://togogenome.org/gene/8083:fitm1 ^@ http://purl.uniprot.org/uniprot/M3ZVE3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIT family. FIT1 subfamily.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May play a role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol.|||Membrane http://togogenome.org/gene/8083:LOC102234341 ^@ http://purl.uniprot.org/uniprot/A0A3B5R0D6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102221236 ^@ http://purl.uniprot.org/uniprot/A0A3B5PRZ7 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/8083:LOC102229209 ^@ http://purl.uniprot.org/uniprot/A0A3B5PSL8 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/8083:LOC102238259 ^@ http://purl.uniprot.org/uniprot/A0A3B5QP04 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102233773 ^@ http://purl.uniprot.org/uniprot/A0A3B5PYY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM86 family.|||Membrane http://togogenome.org/gene/8083:LOC102236841 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUM4 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:LOC102231680 ^@ http://purl.uniprot.org/uniprot/M4AYP3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:camk1d ^@ http://purl.uniprot.org/uniprot/M4A2H0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:ddx21 ^@ http://purl.uniprot.org/uniprot/A0A3B5QLD8 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily. http://togogenome.org/gene/8083:LOC102227291 ^@ http://purl.uniprot.org/uniprot/A0A3B5QBW9 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/8083:tmem59 ^@ http://purl.uniprot.org/uniprot/M3ZE17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM59 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:LOC102235557 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBY2 ^@ Similarity ^@ Belongs to the liprin family. Liprin-beta subfamily. http://togogenome.org/gene/8083:exoc8 ^@ http://purl.uniprot.org/uniprot/M3ZW09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EXO84 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||growth cone|||perinuclear region http://togogenome.org/gene/8083:myadml2 ^@ http://purl.uniprot.org/uniprot/M4AYF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/8083:LOC102220430 ^@ http://purl.uniprot.org/uniprot/A0A3B5QCA1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Homodimer or homotetramer; both forms have similar enzymatic activities.|||Membrane http://togogenome.org/gene/8083:LOC102216789 ^@ http://purl.uniprot.org/uniprot/M3ZQP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/8083:LOC102228097 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q7S6 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.|||Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).|||Cytoplasm|||Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. http://togogenome.org/gene/8083:ebna1bp2 ^@ http://purl.uniprot.org/uniprot/M4AA80 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP2 family.|||Required for the processing of the 27S pre-rRNA.|||nucleolus http://togogenome.org/gene/8083:gnal ^@ http://purl.uniprot.org/uniprot/M3ZFJ2 ^@ Similarity ^@ Belongs to the G-alpha family. G(s) subfamily. http://togogenome.org/gene/8083:ppib ^@ http://purl.uniprot.org/uniprot/A0A3B5QHF2 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/8083:trim45 ^@ http://purl.uniprot.org/uniprot/M4A5U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/8083:pgs1 ^@ http://purl.uniprot.org/uniprot/M4AMS1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-II family.|||Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.|||Mitochondrion http://togogenome.org/gene/8083:adgra2 ^@ http://purl.uniprot.org/uniprot/M3ZI17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/8083:LOC102227221 ^@ http://purl.uniprot.org/uniprot/M4ALR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Secreted http://togogenome.org/gene/8083:LOC102226035 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q713 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 zinc ion per subunit.|||Homotetramer.|||Involved in the regulation of homocysteine metabolism. http://togogenome.org/gene/8083:nsg2 ^@ http://purl.uniprot.org/uniprot/M3ZDJ7 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/8083:LOC102216676 ^@ http://purl.uniprot.org/uniprot/M4A188 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102233675 ^@ http://purl.uniprot.org/uniprot/M4AXI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/8083:sumf1 ^@ http://purl.uniprot.org/uniprot/M3ZJ98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase-modifying factor family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/8083:polr2j ^@ http://purl.uniprot.org/uniprot/M4AD97 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.|||Nucleus http://togogenome.org/gene/8083:srpx2 ^@ http://purl.uniprot.org/uniprot/M4AGH4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:ndufb6 ^@ http://purl.uniprot.org/uniprot/M3ZTC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB6 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102227725 ^@ http://purl.uniprot.org/uniprot/M4AZ74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/8083:vps18 ^@ http://purl.uniprot.org/uniprot/M3ZX52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS18 family.|||Membrane http://togogenome.org/gene/8083:LOC102225532 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDQ9 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/8083:def8 ^@ http://purl.uniprot.org/uniprot/M3ZLE8 ^@ Similarity ^@ Belongs to the DEF8 family. http://togogenome.org/gene/8083:LOC102221722 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0Y0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:mri1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R5R5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:rdh10 ^@ http://purl.uniprot.org/uniprot/A0A3B5PWR9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:LOC102231336 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAV8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102235401 ^@ http://purl.uniprot.org/uniprot/M4AG59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane http://togogenome.org/gene/8083:esyt2 ^@ http://purl.uniprot.org/uniprot/A0A3B5RFE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the extended synaptotagmin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:plcd1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q6G2 ^@ Cofactor ^@ Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain. http://togogenome.org/gene/8083:LOC102220971 ^@ http://purl.uniprot.org/uniprot/M4A6I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:LOC102222784 ^@ http://purl.uniprot.org/uniprot/M3ZWQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family.|||Nucleus http://togogenome.org/gene/8083:LOC102237643 ^@ http://purl.uniprot.org/uniprot/M4ANJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/8083:ap3b2 ^@ http://purl.uniprot.org/uniprot/M3ZIG8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes large subunit family.|||Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.|||clathrin-coated vesicle membrane http://togogenome.org/gene/8083:ccser1 ^@ http://purl.uniprot.org/uniprot/M4ALM1 ^@ Similarity ^@ Belongs to the CCSER family. http://togogenome.org/gene/8083:eftud2 ^@ http://purl.uniprot.org/uniprot/M4A236 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:chrna9 ^@ http://purl.uniprot.org/uniprot/M4A5F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:LOC102234103 ^@ http://purl.uniprot.org/uniprot/A0A3B5R9E6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/8083:ppp6r3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QC42|||http://purl.uniprot.org/uniprot/M4APB5 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/8083:LOC102220326 ^@ http://purl.uniprot.org/uniprot/M4AU54 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/8083:eipr1 ^@ http://purl.uniprot.org/uniprot/M4AWB0 ^@ Similarity ^@ Belongs to the WD repeat EIPR1 family. http://togogenome.org/gene/8083:yif1b ^@ http://purl.uniprot.org/uniprot/M4AUS1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Membrane http://togogenome.org/gene/8083:nubp2 ^@ http://purl.uniprot.org/uniprot/M4A608 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. http://togogenome.org/gene/8083:slc7a9 ^@ http://purl.uniprot.org/uniprot/A0A3B5RD74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:higd2a ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9C5 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/8083:ddx20 ^@ http://purl.uniprot.org/uniprot/M3ZZF4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/8083:spcs1 ^@ http://purl.uniprot.org/uniprot/M3ZP99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:lsm6 ^@ http://purl.uniprot.org/uniprot/M4A582 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/8083:znf532 ^@ http://purl.uniprot.org/uniprot/A0A3B5QA17 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/8083:LOC102227331 ^@ http://purl.uniprot.org/uniprot/M3ZHR4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex.|||Endoplasmic reticulum membrane|||Membrane|||The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (By similarity). The SEC61 channel associates with the multi-pass translocon (MPT) complex. http://togogenome.org/gene/8083:LOC102235788 ^@ http://purl.uniprot.org/uniprot/M4ARA6 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/8083:polr2e ^@ http://purl.uniprot.org/uniprot/A0A3B5R456 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.|||Nucleus http://togogenome.org/gene/8083:vwc2l ^@ http://purl.uniprot.org/uniprot/A0A3B5PT52 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/8083:LOC102217300 ^@ http://purl.uniprot.org/uniprot/A0A3B5QVP7 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/8083:naprt ^@ http://purl.uniprot.org/uniprot/M3ZI00 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/8083:sema3g ^@ http://purl.uniprot.org/uniprot/M4AY03 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102232928 ^@ http://purl.uniprot.org/uniprot/M4ABC6 ^@ Similarity ^@ Belongs to the DSD1 family. http://togogenome.org/gene/8083:LOC102224281 ^@ http://purl.uniprot.org/uniprot/A0A3B5R821 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space http://togogenome.org/gene/8083:dnaaf2 ^@ http://purl.uniprot.org/uniprot/M4A925 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIH1 family. Kintoun subfamily.|||Cytoplasm|||Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. http://togogenome.org/gene/8083:pard6b ^@ http://purl.uniprot.org/uniprot/M4AQA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/8083:LOC102235305 ^@ http://purl.uniprot.org/uniprot/M4AMP5 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.|||Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.|||cytoskeleton|||extracellular space|||nucleoplasm|||sarcolemma http://togogenome.org/gene/8083:LOC102234622 ^@ http://purl.uniprot.org/uniprot/A0A3B5QB90 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:LOC102224293 ^@ http://purl.uniprot.org/uniprot/A0A3B5QV54 ^@ Similarity ^@ Belongs to the UPF0461 family. http://togogenome.org/gene/8083:LOC102223801 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAK4 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/8083:comtd1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVW9 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/8083:LOC102232721 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8Q7 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Mitochondrion outer membrane http://togogenome.org/gene/8083:eif4ebp2 ^@ http://purl.uniprot.org/uniprot/M3ZLS2 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/8083:LOC102225238 ^@ http://purl.uniprot.org/uniprot/M4ADG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.|||Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.|||cytoskeleton http://togogenome.org/gene/8083:hpdl ^@ http://purl.uniprot.org/uniprot/M3ZDZ9 ^@ Cofactor|||Similarity ^@ Belongs to the 4HPPD family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/8083:LOC102234044 ^@ http://purl.uniprot.org/uniprot/M4AN83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/8083:pop7 ^@ http://purl.uniprot.org/uniprot/M4AZ98 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone-like Alba family.|||Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.|||nucleolus http://togogenome.org/gene/8083:foxe1 ^@ http://purl.uniprot.org/uniprot/M4B0I4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102236219 ^@ http://purl.uniprot.org/uniprot/M4AFJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRH/QCR6 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:prkg2 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q6Q7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. http://togogenome.org/gene/8083:med21 ^@ http://purl.uniprot.org/uniprot/A0A3B5RF61 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 21 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/8083:LOC102219946 ^@ http://purl.uniprot.org/uniprot/A0A3B5QH54 ^@ Similarity ^@ Belongs to the VPS26 family. http://togogenome.org/gene/8083:LOC102216705 ^@ http://purl.uniprot.org/uniprot/M4A080 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/8083:LOC102217246 ^@ http://purl.uniprot.org/uniprot/M4AZK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/8083:LOC102234856 ^@ http://purl.uniprot.org/uniprot/M3ZNI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/8083:LOC102227459 ^@ http://purl.uniprot.org/uniprot/M3ZG35 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/8083:LOC102219275 ^@ http://purl.uniprot.org/uniprot/M4AWK8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:tmem254 ^@ http://purl.uniprot.org/uniprot/M3ZZA0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:lsm14a ^@ http://purl.uniprot.org/uniprot/M4AQ13 ^@ Similarity ^@ Belongs to the LSM14 family. http://togogenome.org/gene/8083:LOC102237262 ^@ http://purl.uniprot.org/uniprot/M3ZPS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELAPOR family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:tob1 ^@ http://purl.uniprot.org/uniprot/M4AZE4 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/8083:mvp ^@ http://purl.uniprot.org/uniprot/M4A5E4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:LOC102237939 ^@ http://purl.uniprot.org/uniprot/M3ZFD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM132 family.|||Membrane http://togogenome.org/gene/8083:pdia4 ^@ http://purl.uniprot.org/uniprot/M4AWT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/8083:LOC102230279 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBS3 ^@ Similarity ^@ Belongs to the BtpA family. http://togogenome.org/gene/8083:myb ^@ http://purl.uniprot.org/uniprot/M3ZQD3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102233266 ^@ http://purl.uniprot.org/uniprot/M3ZJ33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/8083:LOC102218647 ^@ http://purl.uniprot.org/uniprot/M3ZEZ3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular space http://togogenome.org/gene/8083:rps6kb2 ^@ http://purl.uniprot.org/uniprot/M3ZRA4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/8083:psmb6 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q7A6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus|||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. http://togogenome.org/gene/8083:acadm ^@ http://purl.uniprot.org/uniprot/M4AKL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/8083:LOC102228551 ^@ http://purl.uniprot.org/uniprot/M3ZPF0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:clstn3 ^@ http://purl.uniprot.org/uniprot/M4A9R3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calsyntenin family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Postsynaptic cell membrane http://togogenome.org/gene/8083:rpl13a ^@ http://purl.uniprot.org/uniprot/A0A3B5QBD8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/8083:isyna1 ^@ http://purl.uniprot.org/uniprot/M4A6R8 ^@ Similarity ^@ Belongs to the myo-inositol 1-phosphate synthase family. http://togogenome.org/gene/8083:cops4 ^@ http://purl.uniprot.org/uniprot/A0A3B5R5R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN4 family.|||Nucleus|||Vesicle|||synaptic vesicle http://togogenome.org/gene/8083:tm2d3 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVN6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102223636 ^@ http://purl.uniprot.org/uniprot/M4ADJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/8083:nipal3 ^@ http://purl.uniprot.org/uniprot/M3ZZR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/8083:zar1l ^@ http://purl.uniprot.org/uniprot/M4A204 ^@ Similarity ^@ Belongs to the ZAR1 family. http://togogenome.org/gene/8083:LOC102232521 ^@ http://purl.uniprot.org/uniprot/M4A4M0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/8083:ahdc1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QXA3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:rsl24d1 ^@ http://purl.uniprot.org/uniprot/A0A3B5REP6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/8083:LOC102227203 ^@ http://purl.uniprot.org/uniprot/M4AYR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102217557 ^@ http://purl.uniprot.org/uniprot/M4AQN4 ^@ Similarity ^@ Belongs to the annexin family. http://togogenome.org/gene/8083:LOC102220081 ^@ http://purl.uniprot.org/uniprot/M3ZVU0 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/8083:ints14 ^@ http://purl.uniprot.org/uniprot/M4AMX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INTS14 family.|||Nucleus|||Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. http://togogenome.org/gene/8083:LOC102226374 ^@ http://purl.uniprot.org/uniprot/A0A3B5QUT5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:xirp2 ^@ http://purl.uniprot.org/uniprot/A0A3B5R197 ^@ Domain|||Similarity ^@ Belongs to the Xin family.|||Xin repeats bind F-actin. http://togogenome.org/gene/8083:cdc37l1 ^@ http://purl.uniprot.org/uniprot/M3ZGV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102220142 ^@ http://purl.uniprot.org/uniprot/M3ZTA1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:med10 ^@ http://purl.uniprot.org/uniprot/A0A3B5PT32 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 10 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/8083:LOC106700093 ^@ http://purl.uniprot.org/uniprot/M3ZG18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/8083:LOC102223036 ^@ http://purl.uniprot.org/uniprot/A0A3B5QL20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/8083:myc ^@ http://purl.uniprot.org/uniprot/M3ZII1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.|||Nucleus|||Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. http://togogenome.org/gene/8083:pou4f2 ^@ http://purl.uniprot.org/uniprot/M4AWH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/8083:LOC102234792 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/8083:LOC102237299 ^@ http://purl.uniprot.org/uniprot/M4AHV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:LOC102217007 ^@ http://purl.uniprot.org/uniprot/A0A3B5R5K9|||http://purl.uniprot.org/uniprot/M4AR77 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:tdo2 ^@ http://purl.uniprot.org/uniprot/M3ZJ80 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the tryptophan 2,3-dioxygenase family.|||Binds 1 heme group per subunit.|||Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.|||Homotetramer. Dimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102218649 ^@ http://purl.uniprot.org/uniprot/M4AEE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Membrane|||Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity. http://togogenome.org/gene/8083:tor3a ^@ http://purl.uniprot.org/uniprot/A0A3B5R8S9 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. Torsin subfamily. http://togogenome.org/gene/8083:mgat1 ^@ http://purl.uniprot.org/uniprot/M4AFU5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.|||Membrane|||The cofactor is mostly bound to the substrate. http://togogenome.org/gene/8083:fam136a ^@ http://purl.uniprot.org/uniprot/M3ZPW3 ^@ Similarity ^@ Belongs to the FAM136 family. http://togogenome.org/gene/8083:slc16a7 ^@ http://purl.uniprot.org/uniprot/M4A6U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/8083:LOC102238048 ^@ http://purl.uniprot.org/uniprot/M4AEV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/8083:gla ^@ http://purl.uniprot.org/uniprot/A0A3B5QM29 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/8083:slc35f6 ^@ http://purl.uniprot.org/uniprot/A0A3B5REV1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLC35F solute transporter family.|||Interacts with SLC25A5.|||May play a role as a nucleotide-sugar transporter.|||Membrane|||Mitochondrion http://togogenome.org/gene/8083:LOC102226098 ^@ http://purl.uniprot.org/uniprot/M4AHQ8 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/8083:lmln ^@ http://purl.uniprot.org/uniprot/M4A2E0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M8 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/8083:pin4 ^@ http://purl.uniprot.org/uniprot/M4A718 ^@ Similarity ^@ Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily. http://togogenome.org/gene/8083:orc5 ^@ http://purl.uniprot.org/uniprot/M3ZQX2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102218831 ^@ http://purl.uniprot.org/uniprot/M3ZQ39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/8083:p4hb ^@ http://purl.uniprot.org/uniprot/A0A3B5QL02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/8083:LOC102238300 ^@ http://purl.uniprot.org/uniprot/M4ANA9 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/8083:prkrip1 ^@ http://purl.uniprot.org/uniprot/M4AZP8 ^@ Similarity ^@ Belongs to the PRKRIP1 family. http://togogenome.org/gene/8083:pnrc2 ^@ http://purl.uniprot.org/uniprot/M4AYN4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:begain ^@ http://purl.uniprot.org/uniprot/A0A3B5QNE6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:avl9 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3H8 ^@ Subcellular Location Annotation ^@ Recycling endosome http://togogenome.org/gene/8083:acat1 ^@ http://purl.uniprot.org/uniprot/M4AHQ4 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/8083:glrb ^@ http://purl.uniprot.org/uniprot/M3ZJ40 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102236590 ^@ http://purl.uniprot.org/uniprot/M4AD17 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/8083:timm13 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWP8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/8083:LOC102227927 ^@ http://purl.uniprot.org/uniprot/M4A7G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SH3PXD2 family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102235603 ^@ http://purl.uniprot.org/uniprot/M4A869 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/8083:rpa2 ^@ http://purl.uniprot.org/uniprot/M4AJD7 ^@ Similarity ^@ Belongs to the replication factor A protein 2 family. http://togogenome.org/gene/8083:LOC102228805 ^@ http://purl.uniprot.org/uniprot/M3ZIS2 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/8083:irf7 ^@ http://purl.uniprot.org/uniprot/M4AKX2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102236552 ^@ http://purl.uniprot.org/uniprot/M4ARE3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:LOC102220089 ^@ http://purl.uniprot.org/uniprot/M3ZSI0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:gipc1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZF1 ^@ Similarity ^@ Belongs to the GIPC family. http://togogenome.org/gene/8083:chrnb2 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q5R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:LOC102222770 ^@ http://purl.uniprot.org/uniprot/M4AFT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.|||Membrane|||Nucleus speckle|||filopodium|||lamellipodium http://togogenome.org/gene/8083:LOC102224577 ^@ http://purl.uniprot.org/uniprot/M3ZJA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane|||Sodium-independent sulfate anion transporter. Can transport other anions including bicarbonate, thiosulfate and oxalate. http://togogenome.org/gene/8083:slc7a4 ^@ http://purl.uniprot.org/uniprot/M4ALE9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:psma5 ^@ http://purl.uniprot.org/uniprot/M3ZP86 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/8083:pold3 ^@ http://purl.uniprot.org/uniprot/M3ZV23 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102224221 ^@ http://purl.uniprot.org/uniprot/A0A3B5R4R0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:capn3 ^@ http://purl.uniprot.org/uniprot/M4A4P3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C2 family.|||Calcium-regulated non-lysosomal thiol-protease.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/8083:LOC102237799 ^@ http://purl.uniprot.org/uniprot/M4AWV7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:irf6 ^@ http://purl.uniprot.org/uniprot/M3ZY72 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:mars2 ^@ http://purl.uniprot.org/uniprot/M3ZDK1 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/8083:LOC102220373 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q159 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM53 family.|||Membrane|||Nucleus outer membrane http://togogenome.org/gene/8083:rnf7 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q158 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/8083:LOC102232476 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q7S0 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/8083:mon1a ^@ http://purl.uniprot.org/uniprot/M3ZIX0 ^@ Function|||Similarity ^@ Belongs to the MON1/SAND family.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/8083:LOC102224260 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAY4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:nr5a2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QU75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/8083:plk1 ^@ http://purl.uniprot.org/uniprot/M4AEH2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/8083:atp2b2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHX1|||http://purl.uniprot.org/uniprot/A0A3B5R706|||http://purl.uniprot.org/uniprot/M4ASZ5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:med13l ^@ http://purl.uniprot.org/uniprot/M3ZT85 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 13 family.|||Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/8083:rhbdd3 ^@ http://purl.uniprot.org/uniprot/M4AU37 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:rad50 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7A8 ^@ Similarity ^@ Belongs to the SMC family. RAD50 subfamily. http://togogenome.org/gene/8083:coq9 ^@ http://purl.uniprot.org/uniprot/M4ANG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COQ9 family.|||Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.|||Mitochondrion http://togogenome.org/gene/8083:fabp2 ^@ http://purl.uniprot.org/uniprot/M3ZU10 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8083:rrp12 ^@ http://purl.uniprot.org/uniprot/M4AGH0 ^@ Similarity ^@ Belongs to the RRP12 family. http://togogenome.org/gene/8083:LOC102227768 ^@ http://purl.uniprot.org/uniprot/M4AAU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase CarF family.|||Membrane http://togogenome.org/gene/8083:lrp10 ^@ http://purl.uniprot.org/uniprot/M3ZH43 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:pgm2 ^@ http://purl.uniprot.org/uniprot/M4AE43 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/8083:LOC102226296 ^@ http://purl.uniprot.org/uniprot/M4AE99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/8083:gnpda2 ^@ http://purl.uniprot.org/uniprot/M4ALY9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/8083:cpb2 ^@ http://purl.uniprot.org/uniprot/M4ADD5 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/8083:cpne2 ^@ http://purl.uniprot.org/uniprot/M3ZUM0 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/8083:tprkb ^@ http://purl.uniprot.org/uniprot/A0A3B5Q5G1 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/8083:mfsd8 ^@ http://purl.uniprot.org/uniprot/M4ADN6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:hint1 ^@ http://purl.uniprot.org/uniprot/A0A3B5REC8 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/8083:LOC102218372 ^@ http://purl.uniprot.org/uniprot/M3ZN74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:fam160a2 ^@ http://purl.uniprot.org/uniprot/M3ZG76 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/8083:cfap97 ^@ http://purl.uniprot.org/uniprot/M3ZTW3 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/8083:lmf1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUF1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lipase maturation factor family.|||Endoplasmic reticulum membrane|||Involved in the maturation of specific proteins in the endoplasmic reticulum.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102227741 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q044 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/8083:timm21 ^@ http://purl.uniprot.org/uniprot/M4AVS6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM21 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/8083:LOC102236058 ^@ http://purl.uniprot.org/uniprot/M4A9X2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Membrane|||Midbody|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. http://togogenome.org/gene/8083:rorb ^@ http://purl.uniprot.org/uniprot/M4AMC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/8083:cplx4 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q2E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/8083:mag ^@ http://purl.uniprot.org/uniprot/M3ZWM8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102231309 ^@ http://purl.uniprot.org/uniprot/A0A3B5QV76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIP3 family.|||Membrane http://togogenome.org/gene/8083:LOC102221918 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQZ5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/8083:ss18l2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZS7 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/8083:mrps14 ^@ http://purl.uniprot.org/uniprot/A0A3B5QDZ5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/8083:LOC102220440 ^@ http://purl.uniprot.org/uniprot/M3ZH06 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GDNFR family.|||Cell membrane|||Membrane|||Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. http://togogenome.org/gene/8083:LOC102225792 ^@ http://purl.uniprot.org/uniprot/M3ZS71 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/8083:LOC102217177 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/8083:LOC102235463 ^@ http://purl.uniprot.org/uniprot/A0A3B5R2K7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/8083:LOC102231627 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q2Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/8083:bgn ^@ http://purl.uniprot.org/uniprot/M4A1P4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||May be involved in collagen fiber assembly.|||extracellular matrix http://togogenome.org/gene/8083:rab39b ^@ http://purl.uniprot.org/uniprot/M3ZGX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102224442 ^@ http://purl.uniprot.org/uniprot/M3ZGL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNTF family.|||CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.|||Cytoplasm http://togogenome.org/gene/8083:rpl35 ^@ http://purl.uniprot.org/uniprot/M3ZL31 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/8083:LOC102227834 ^@ http://purl.uniprot.org/uniprot/M4AQG2 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/8083:ssh1 ^@ http://purl.uniprot.org/uniprot/M4AUV6 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/8083:LOC102222372 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHE9 ^@ Similarity ^@ Belongs to the peptidase C64 family. http://togogenome.org/gene/8083:ext2 ^@ http://purl.uniprot.org/uniprot/M3ZYF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/8083:adprhl2 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9Q0 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/8083:LOC102218632 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAM2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked.|||Its primary function is the prevention of hypercalcemia. Upon release into the circulation, it lowers calcium transport by the gills, thereby reducing its rate of influx from the environment into the extracellular compartment. STC also stimulates phosphate reabsorption by renal proximal tubules. The consequence of this action is increased levels of plasma phosphate, which combines with excess calcium and promotes its disposal into bone and scales. http://togogenome.org/gene/8083:kif20a ^@ http://purl.uniprot.org/uniprot/M4AET5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/8083:slc31a2 ^@ http://purl.uniprot.org/uniprot/M4A9D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/8083:LOC102230510 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUN6|||http://purl.uniprot.org/uniprot/A0A3B5PVP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/8083:ptges ^@ http://purl.uniprot.org/uniprot/A0A3B5QKA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/8083:tmem88 ^@ http://purl.uniprot.org/uniprot/M4A3F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM88 family.|||Membrane http://togogenome.org/gene/8083:e2f3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QFH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/8083:LOC102223312 ^@ http://purl.uniprot.org/uniprot/M4AQV6 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/8083:tk1 ^@ http://purl.uniprot.org/uniprot/M3ZDG1 ^@ Similarity ^@ Belongs to the thymidine kinase family. http://togogenome.org/gene/8083:LOC102238130 ^@ http://purl.uniprot.org/uniprot/M4ACY6 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/8083:thoc5 ^@ http://purl.uniprot.org/uniprot/M3ZZ99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC5 family.|||Nucleus http://togogenome.org/gene/8083:mrps11 ^@ http://purl.uniprot.org/uniprot/M4AAY5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/8083:LOC102221221 ^@ http://purl.uniprot.org/uniprot/A0A3B5R0M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102225814 ^@ http://purl.uniprot.org/uniprot/M4A702 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:exoc5 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q5K2 ^@ Similarity ^@ Belongs to the SEC10 family. http://togogenome.org/gene/8083:LOC102226315 ^@ http://purl.uniprot.org/uniprot/M4A2L1 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/8083:LOC102223744 ^@ http://purl.uniprot.org/uniprot/M3ZFC8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular space http://togogenome.org/gene/8083:cope ^@ http://purl.uniprot.org/uniprot/A0A3B5QY69 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPE family.|||Cytoplasm|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/8083:LOC102229138 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Golgi stack membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/8083:LOC102222387 ^@ http://purl.uniprot.org/uniprot/A0A3B5R442 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/8083:ckb ^@ http://purl.uniprot.org/uniprot/A0A3B5Q511 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/8083:fam3c ^@ http://purl.uniprot.org/uniprot/M4AW22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/8083:st6galnac3 ^@ http://purl.uniprot.org/uniprot/M4APN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8083:vps54 ^@ http://purl.uniprot.org/uniprot/A0A3B5R3N6 ^@ Similarity ^@ Belongs to the VPS54 family. http://togogenome.org/gene/8083:idnk ^@ http://purl.uniprot.org/uniprot/A0A3B5RAH5 ^@ Similarity ^@ Belongs to the gluconokinase GntK/GntV family. http://togogenome.org/gene/8083:slc39a9 ^@ http://purl.uniprot.org/uniprot/A0A3B5QL31 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Cell membrane|||Membrane|||Mitochondrion|||Nucleus|||Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.|||perinuclear region|||trans-Golgi network membrane http://togogenome.org/gene/8083:entpd5 ^@ http://purl.uniprot.org/uniprot/M4AL21 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/8083:LOC102230489 ^@ http://purl.uniprot.org/uniprot/M3ZVB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8083:scn3b ^@ http://purl.uniprot.org/uniprot/M4A3A5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.|||Membrane|||Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. http://togogenome.org/gene/8083:LOC102236248 ^@ http://purl.uniprot.org/uniprot/A0A3B5QA23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:nodal ^@ http://purl.uniprot.org/uniprot/M4AL00 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/8083:eif3m ^@ http://purl.uniprot.org/uniprot/M4AIE0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Belongs to the eIF-3 subunit M family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm http://togogenome.org/gene/8083:LOC102231029 ^@ http://purl.uniprot.org/uniprot/M4AI46 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit beta family.|||Heterodimer of an alpha and a beta chain.|||Involved in gametogenesis and steroidogenesis.|||Secreted http://togogenome.org/gene/8083:coro2b ^@ http://purl.uniprot.org/uniprot/A0A3B5QJH1 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/8083:tmem39b ^@ http://purl.uniprot.org/uniprot/M3ZW65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/8083:LOC102220940 ^@ http://purl.uniprot.org/uniprot/M4AXL2 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/8083:acmsd ^@ http://purl.uniprot.org/uniprot/M3ZII2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.|||Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.|||Monomer. http://togogenome.org/gene/8083:trmt6 ^@ http://purl.uniprot.org/uniprot/M4A2B7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM6/GCD10 family.|||Heterotetramer.|||Nucleus|||Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. http://togogenome.org/gene/8083:agpat4 ^@ http://purl.uniprot.org/uniprot/M4A5C5 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/8083:dnajb14 ^@ http://purl.uniprot.org/uniprot/M4A6U2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:pfdn6 ^@ http://purl.uniprot.org/uniprot/A0A3B5RC30 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/8083:htr2a ^@ http://purl.uniprot.org/uniprot/M4A4C4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin).|||Membrane|||Presynapse|||axon|||caveola|||dendrite http://togogenome.org/gene/8083:prmt3 ^@ http://purl.uniprot.org/uniprot/A0A3B5RE87 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:lrrc8a ^@ http://purl.uniprot.org/uniprot/M3ZU12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102218652 ^@ http://purl.uniprot.org/uniprot/A0A3B5R726 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8083:tpra1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PPG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0359 family.|||Membrane http://togogenome.org/gene/8083:uba1 ^@ http://purl.uniprot.org/uniprot/M4A1H0 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/8083:msra ^@ http://purl.uniprot.org/uniprot/A0A3B5QEJ4 ^@ Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family. http://togogenome.org/gene/8083:LOC102230321 ^@ http://purl.uniprot.org/uniprot/A0A3B5R852 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. http://togogenome.org/gene/8083:LOC102220343 ^@ http://purl.uniprot.org/uniprot/M4APK4 ^@ Similarity ^@ Belongs to the IUNH family. http://togogenome.org/gene/8083:kmo ^@ http://purl.uniprot.org/uniprot/M3ZZT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aromatic-ring hydroxylase family. KMO subfamily.|||Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.|||Mitochondrion outer membrane http://togogenome.org/gene/8083:LOC102223456 ^@ http://purl.uniprot.org/uniprot/M4AWL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Cell membrane|||Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.|||Membrane http://togogenome.org/gene/8083:rtn4 ^@ http://purl.uniprot.org/uniprot/M3ZD84 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:elac1 ^@ http://purl.uniprot.org/uniprot/M4ALY5 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/8083:LOC102226324 ^@ http://purl.uniprot.org/uniprot/M4AS04 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/8083:jph1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R5I8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/8083:lef1 ^@ http://purl.uniprot.org/uniprot/M4A6Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/8083:srp14 ^@ http://purl.uniprot.org/uniprot/M3ZWP3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP14 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm|||Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. http://togogenome.org/gene/8083:thg1l ^@ http://purl.uniprot.org/uniprot/M4A1B5 ^@ Cofactor|||Function|||Similarity ^@ Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.|||Belongs to the tRNA(His) guanylyltransferase family.|||Binds 2 magnesium ions per subunit. http://togogenome.org/gene/8083:LOC102237833 ^@ http://purl.uniprot.org/uniprot/A0A3B5R147 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:LOC102233533 ^@ http://purl.uniprot.org/uniprot/A0A3B5QDY7 ^@ Similarity ^@ Belongs to the TACO1 family. http://togogenome.org/gene/8083:klc1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q850 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/8083:gosr2 ^@ http://purl.uniprot.org/uniprot/M4A439 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOSR2 family.|||Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.|||Membrane http://togogenome.org/gene/8083:asphd2 ^@ http://purl.uniprot.org/uniprot/M3ZL93 ^@ Similarity ^@ Belongs to the aspartyl/asparaginyl beta-hydroxylase family. http://togogenome.org/gene/8083:LOC102219538 ^@ http://purl.uniprot.org/uniprot/A0A3B5PRG4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:nck2 ^@ http://purl.uniprot.org/uniprot/A0A3B5R728 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/8083:LOC102225211 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPR5 ^@ Similarity ^@ Belongs to the ependymin family. http://togogenome.org/gene/8083:LOC102236001 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q839 ^@ Similarity ^@ Belongs to the RIN (Ras interaction/interference) family. http://togogenome.org/gene/8083:LOC102230409 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPU6 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/8083:LOC102232228 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQX4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/8083:dnaja2 ^@ http://purl.uniprot.org/uniprot/M4AC68 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:mrpl11 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUE3 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL11 family.|||Binds directly to 26S ribosomal RNA. http://togogenome.org/gene/8083:zfp36l2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQ84 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Nucleus|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/8083:trappc11 ^@ http://purl.uniprot.org/uniprot/M4A989 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPPC11 family.|||Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.|||cis-Golgi network http://togogenome.org/gene/8083:per2 ^@ http://purl.uniprot.org/uniprot/M3ZWW5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/8083:cdc6 ^@ http://purl.uniprot.org/uniprot/M4AIA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC6/cdc18 family.|||Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.|||Nucleus http://togogenome.org/gene/8083:blm ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8Z5 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/8083:LOC102232616 ^@ http://purl.uniprot.org/uniprot/M3ZVT9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/8083:pelo ^@ http://purl.uniprot.org/uniprot/M4AVM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.|||Cytoplasm http://togogenome.org/gene/8083:smc1a ^@ http://purl.uniprot.org/uniprot/M4A967 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/8083:LOC102228624 ^@ http://purl.uniprot.org/uniprot/M4AG73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/8083:cdk2ap2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PWT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDK2AP family.|||Nucleus http://togogenome.org/gene/8083:LOC102219385 ^@ http://purl.uniprot.org/uniprot/M4AAG1 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-1 subfamily. http://togogenome.org/gene/8083:pdgfc ^@ http://purl.uniprot.org/uniprot/M3ZJ42 ^@ Caution|||Similarity ^@ Belongs to the PDGF/VEGF growth factor family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102218624 ^@ http://purl.uniprot.org/uniprot/A0A3B5QFX8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Secreted http://togogenome.org/gene/8083:slc25a17 ^@ http://purl.uniprot.org/uniprot/M3ZGX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:spns1 ^@ http://purl.uniprot.org/uniprot/M4A908 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.|||Membrane http://togogenome.org/gene/8083:pmm1 ^@ http://purl.uniprot.org/uniprot/M3ZXN6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/8083:LOC102227239 ^@ http://purl.uniprot.org/uniprot/M3ZRU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102237271 ^@ http://purl.uniprot.org/uniprot/A0A3B5R486 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/8083:LOC106699760 ^@ http://purl.uniprot.org/uniprot/A0A3B5PQG5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:LOC102225856 ^@ http://purl.uniprot.org/uniprot/M4AP78 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/8083:pdia6 ^@ http://purl.uniprot.org/uniprot/M4ATN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen|||Melanosome http://togogenome.org/gene/8083:bnip3 ^@ http://purl.uniprot.org/uniprot/M4AE82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIP3 family.|||Membrane http://togogenome.org/gene/8083:LOC102218196 ^@ http://purl.uniprot.org/uniprot/M3ZQ79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:ovca2 ^@ http://purl.uniprot.org/uniprot/M4A7A2 ^@ Similarity ^@ Belongs to the LovG family. http://togogenome.org/gene/8083:LOC102231524 ^@ http://purl.uniprot.org/uniprot/A0A3B5QIW7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. http://togogenome.org/gene/8083:spcs3 ^@ http://purl.uniprot.org/uniprot/M4ANI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS3 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102218382 ^@ http://purl.uniprot.org/uniprot/M3ZI20 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/8083:LOC102234866 ^@ http://purl.uniprot.org/uniprot/M3ZJG8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:stx6 ^@ http://purl.uniprot.org/uniprot/M4AP90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Golgi apparatus membrane http://togogenome.org/gene/8083:smad6 ^@ http://purl.uniprot.org/uniprot/M3ZMW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102237884 ^@ http://purl.uniprot.org/uniprot/M4AHK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:ndufb9 ^@ http://purl.uniprot.org/uniprot/M3ZG89 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102236828 ^@ http://purl.uniprot.org/uniprot/A0A3B5QCG9 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/8083:actr8 ^@ http://purl.uniprot.org/uniprot/M4AXZ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin family. ARP8 subfamily.|||Chromosome|||Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.|||Nucleus|||Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.|||Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. http://togogenome.org/gene/8083:prkar1b ^@ http://purl.uniprot.org/uniprot/A0A3B5QIH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102231495 ^@ http://purl.uniprot.org/uniprot/M3ZJC6 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/8083:lrit3 ^@ http://purl.uniprot.org/uniprot/M3ZJ94 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:uchl1 ^@ http://purl.uniprot.org/uniprot/M4A0Q6 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/8083:nme6 ^@ http://purl.uniprot.org/uniprot/M3ZPK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||Cytoplasm|||Major role in the synthesis of nucleoside triphosphates other than ATP.|||Nucleus|||lamellipodium|||ruffle http://togogenome.org/gene/8083:LOC102231477 ^@ http://purl.uniprot.org/uniprot/M4A5A6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8083:LOC102235084 ^@ http://purl.uniprot.org/uniprot/A0A3B5QBP8 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/8083:adcy9 ^@ http://purl.uniprot.org/uniprot/A0A3B5QG07 ^@ Similarity ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. http://togogenome.org/gene/8083:gdpd1 ^@ http://purl.uniprot.org/uniprot/M4A944 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/8083:LOC102224924 ^@ http://purl.uniprot.org/uniprot/M4ABS7 ^@ Caution|||Cofactor ^@ Binds 1 Fe cation per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102230406 ^@ http://purl.uniprot.org/uniprot/M4A9Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.|||Membrane http://togogenome.org/gene/8083:trmt2a ^@ http://purl.uniprot.org/uniprot/M3ZJP3 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102233525 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUN9 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/8083:LOC102220861 ^@ http://purl.uniprot.org/uniprot/M4AEA9 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/8083:ogdh ^@ http://purl.uniprot.org/uniprot/M4AWU1 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/8083:LOC102231350 ^@ http://purl.uniprot.org/uniprot/M4A5L8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.|||Nucleus http://togogenome.org/gene/8083:ctsh ^@ http://purl.uniprot.org/uniprot/M3ZL60 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/8083:agpat5 ^@ http://purl.uniprot.org/uniprot/M4A7A3 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/8083:LOC102233466 ^@ http://purl.uniprot.org/uniprot/M3ZWK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/8083:psmc4 ^@ http://purl.uniprot.org/uniprot/M4AFP3 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/8083:nipsnap1 ^@ http://purl.uniprot.org/uniprot/M3ZJV8 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/8083:fut11 ^@ http://purl.uniprot.org/uniprot/M4A528 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Probable fucosyltransferase. http://togogenome.org/gene/8083:cnot3 ^@ http://purl.uniprot.org/uniprot/M4ACV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT2/3/5 family.|||Nucleus http://togogenome.org/gene/8083:tmem173 ^@ http://purl.uniprot.org/uniprot/M4AWL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STING family.|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||autophagosome membrane|||perinuclear region http://togogenome.org/gene/8083:LOC102218172 ^@ http://purl.uniprot.org/uniprot/M3ZWX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/8083:LOC102216482 ^@ http://purl.uniprot.org/uniprot/M3ZK83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/8083:LOC102230576 ^@ http://purl.uniprot.org/uniprot/M3ZQW7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:laptm4a ^@ http://purl.uniprot.org/uniprot/A0A3B5PXA3 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/8083:txndc5 ^@ http://purl.uniprot.org/uniprot/M3ZUX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/8083:LOC102227514 ^@ http://purl.uniprot.org/uniprot/M4A6W1 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/8083:cd63 ^@ http://purl.uniprot.org/uniprot/M4AB61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:cpsf2 ^@ http://purl.uniprot.org/uniprot/M4ARN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/8083:ubxn1 ^@ http://purl.uniprot.org/uniprot/M3ZSW4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:polrmt ^@ http://purl.uniprot.org/uniprot/M4ADE6 ^@ Function|||Similarity ^@ Belongs to the phage and mitochondrial RNA polymerase family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/8083:slc20a2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QDM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/8083:LOC102223994 ^@ http://purl.uniprot.org/uniprot/A0A3B5RF35 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alkaline phosphatase family.|||Binds 1 Mg(2+) ion.|||Binds 2 Zn(2+) ions.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/8083:arpc3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QY33 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC3 family.|||Component of the Arp2/3 complex.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/8083:srrd ^@ http://purl.uniprot.org/uniprot/M3ZZA8 ^@ Similarity ^@ Belongs to the SRR1 family. http://togogenome.org/gene/8083:acap1 ^@ http://purl.uniprot.org/uniprot/M4AMC6 ^@ Activity Regulation|||Domain|||Function|||Subcellular Location Annotation ^@ Endosome membrane|||GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.|||GTPase-activating protein for the ADP ribosylation factor family.|||PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.|||The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions. http://togogenome.org/gene/8083:LOC102227536 ^@ http://purl.uniprot.org/uniprot/M3ZE53 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102236601 ^@ http://purl.uniprot.org/uniprot/M4A9Z1 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/8083:LOC102236845 ^@ http://purl.uniprot.org/uniprot/A0A3B5QU26 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. http://togogenome.org/gene/8083:LOC102220863 ^@ http://purl.uniprot.org/uniprot/M3ZQ94 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/8083:gpr158 ^@ http://purl.uniprot.org/uniprot/A0A3B5QB76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:LOC102221802 ^@ http://purl.uniprot.org/uniprot/M4A2K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:mif ^@ http://purl.uniprot.org/uniprot/A0A3B5QN81 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/8083:LOC102216440 ^@ http://purl.uniprot.org/uniprot/A0A3B5QB67 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/8083:tmem43 ^@ http://purl.uniprot.org/uniprot/M4AR25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM43 family.|||Membrane http://togogenome.org/gene/8083:LOC102226994 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8X6 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/8083:LOC102219963 ^@ http://purl.uniprot.org/uniprot/M4ACG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TM6SF family.|||Membrane http://togogenome.org/gene/8083:dohh ^@ http://purl.uniprot.org/uniprot/A0A3B5Q024 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the deoxyhypusine hydroxylase family.|||Binds 2 Fe(2+) ions per subunit.|||Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. http://togogenome.org/gene/8083:LOC102216967 ^@ http://purl.uniprot.org/uniprot/M4ADD3 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/8083:LOC106699660 ^@ http://purl.uniprot.org/uniprot/A0A3B5R2W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM229 family.|||Membrane http://togogenome.org/gene/8083:eps8l2 ^@ http://purl.uniprot.org/uniprot/M3ZNJ0 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/8083:uncx ^@ http://purl.uniprot.org/uniprot/A0A3B5R100 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:nkx1-1 ^@ http://purl.uniprot.org/uniprot/M4ASX3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102233721 ^@ http://purl.uniprot.org/uniprot/M4AP32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C26 family.|||extracellular space http://togogenome.org/gene/8083:slc26a2 ^@ http://purl.uniprot.org/uniprot/M4AXS0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane|||Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion. http://togogenome.org/gene/8083:LOC102229295 ^@ http://purl.uniprot.org/uniprot/A0A3B5QSY9 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/8083:LOC102237096 ^@ http://purl.uniprot.org/uniprot/A0A3B5R0L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/8083:LOC102217844 ^@ http://purl.uniprot.org/uniprot/M4ALT5 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/8083:slc35e2b ^@ http://purl.uniprot.org/uniprot/M4AY91 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102235657 ^@ http://purl.uniprot.org/uniprot/A0A3B5QEF8 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/8083:scnm1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QP95 ^@ Subcellular Location Annotation ^@ Nucleus speckle|||nucleoplasm http://togogenome.org/gene/8083:LOC102233143 ^@ http://purl.uniprot.org/uniprot/A0A3B5PSM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the C19orf12 family.|||Mitochondrion membrane http://togogenome.org/gene/8083:LOC102220621 ^@ http://purl.uniprot.org/uniprot/M4AZM0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:ap1m1 ^@ http://purl.uniprot.org/uniprot/M3ZEJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Golgi apparatus|||Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.|||clathrin-coated vesicle membrane http://togogenome.org/gene/8083:LOC102237504 ^@ http://purl.uniprot.org/uniprot/M4ALT7 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/8083:LOC102226859 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDD3 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/8083:esam ^@ http://purl.uniprot.org/uniprot/M3ZV71 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:nampt ^@ http://purl.uniprot.org/uniprot/A0A3B5R6J6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAPRTase family.|||Cytoplasm|||Homodimer.|||Nucleus|||Secreted http://togogenome.org/gene/8083:eda ^@ http://purl.uniprot.org/uniprot/M4A597 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/8083:LOC102233235 ^@ http://purl.uniprot.org/uniprot/M3ZLZ6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8083:wscd1 ^@ http://purl.uniprot.org/uniprot/M4AHZ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WSCD family.|||Golgi apparatus membrane|||Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. http://togogenome.org/gene/8083:LOC102227163 ^@ http://purl.uniprot.org/uniprot/A0A3B5QI03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cell surface|||Endosome|||Membrane http://togogenome.org/gene/8083:b3gat2 ^@ http://purl.uniprot.org/uniprot/M3ZYN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:grhl3 ^@ http://purl.uniprot.org/uniprot/M4AGR7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:mrps12 ^@ http://purl.uniprot.org/uniprot/A0A3B5PTV7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/8083:LOC102229925 ^@ http://purl.uniprot.org/uniprot/M4AN70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hedgehog family.|||Cell membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Multimer.|||The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.|||The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. http://togogenome.org/gene/8083:LOC102238058 ^@ http://purl.uniprot.org/uniprot/A0A3B5RCF9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102229527 ^@ http://purl.uniprot.org/uniprot/A0A3B5PRJ7 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-1 subfamily. http://togogenome.org/gene/8083:actr2 ^@ http://purl.uniprot.org/uniprot/M4ABL2 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/8083:LOC102226898 ^@ http://purl.uniprot.org/uniprot/M3ZU73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8083:ncbp2 ^@ http://purl.uniprot.org/uniprot/M4A6M5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRM NCBP2 family.|||Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.|||Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.|||Nucleus http://togogenome.org/gene/8083:gamt ^@ http://purl.uniprot.org/uniprot/M3ZK64 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.|||Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor.|||Monomer. http://togogenome.org/gene/8083:cog3 ^@ http://purl.uniprot.org/uniprot/M3ZQL2 ^@ Function|||Similarity ^@ Belongs to the COG3 family.|||Involved in ER-Golgi transport. http://togogenome.org/gene/8083:ccdc94 ^@ http://purl.uniprot.org/uniprot/M4A6V4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CWC16 family. YJU2 subfamily.|||Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.|||Nucleus|||Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex. http://togogenome.org/gene/8083:LOC102228034 ^@ http://purl.uniprot.org/uniprot/M4A638 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/8083:slc16a5 ^@ http://purl.uniprot.org/uniprot/M4AJW2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102231468 ^@ http://purl.uniprot.org/uniprot/A0A3B5QY51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/8083:dock2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QIG4 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/8083:LOC102231010 ^@ http://purl.uniprot.org/uniprot/M4B0D3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102234965 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:dctd ^@ http://purl.uniprot.org/uniprot/M4AN45 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/8083:polr3g ^@ http://purl.uniprot.org/uniprot/A0A3B5QW74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/8083:ventx ^@ http://purl.uniprot.org/uniprot/M3ZZH6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:flcn ^@ http://purl.uniprot.org/uniprot/M4ACC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the folliculin family.|||Lysosome membrane|||Membrane|||Nucleus|||centrosome|||cilium|||cytosol|||spindle http://togogenome.org/gene/8083:itpkb ^@ http://purl.uniprot.org/uniprot/M3ZXW6 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/8083:rax ^@ http://purl.uniprot.org/uniprot/M3ZQA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus|||Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. http://togogenome.org/gene/8083:LOC106699766 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAY7 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/8083:mrpl28 ^@ http://purl.uniprot.org/uniprot/M3ZQ08 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/8083:LOC102229874 ^@ http://purl.uniprot.org/uniprot/M3ZNY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms chloride channels.|||Membrane http://togogenome.org/gene/8083:LOC102227192 ^@ http://purl.uniprot.org/uniprot/M4A6G5 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/8083:c1d ^@ http://purl.uniprot.org/uniprot/M4AUT1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the C1D family.|||Cytoplasm|||Monomer and homodimer.|||Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.|||nucleolus http://togogenome.org/gene/8083:kremen1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q161 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102226032 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Elbow/Noc family.|||Nucleus http://togogenome.org/gene/8083:pias4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QDP9 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/8083:epdr1 ^@ http://purl.uniprot.org/uniprot/M3ZX45 ^@ Similarity ^@ Belongs to the ependymin family. http://togogenome.org/gene/8083:tpp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QCK0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102228052 ^@ http://purl.uniprot.org/uniprot/M4AKG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/8083:rack1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PSN1 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. http://togogenome.org/gene/8083:calcrl ^@ http://purl.uniprot.org/uniprot/A0A3B5Q066 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Membrane http://togogenome.org/gene/8083:LOC102219535 ^@ http://purl.uniprot.org/uniprot/A0A3B5QUI3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/8083:LOC102223213 ^@ http://purl.uniprot.org/uniprot/M4A0V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/8083:LOC102233289 ^@ http://purl.uniprot.org/uniprot/M3ZEV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCO1/2 family.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:snx3 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome|||Endosome|||phagosome http://togogenome.org/gene/8083:hoxb9 ^@ http://purl.uniprot.org/uniprot/M3ZKU9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/8083:vcp ^@ http://purl.uniprot.org/uniprot/M3ZZ75 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/8083:LOC102231182 ^@ http://purl.uniprot.org/uniprot/A0A3B5QUR4|||http://purl.uniprot.org/uniprot/A0A3B5QYY4 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/8083:LOC102218225 ^@ http://purl.uniprot.org/uniprot/A0A3B5R1J5 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/8083:gata3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QNP4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:fam72a ^@ http://purl.uniprot.org/uniprot/A0A3B5PXS3 ^@ Similarity ^@ Belongs to the FAM72 family. http://togogenome.org/gene/8083:LOC102218000 ^@ http://purl.uniprot.org/uniprot/A0A3B5R2Q5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:LOC102228710 ^@ http://purl.uniprot.org/uniprot/A0A3B5QK33 ^@ Similarity ^@ Belongs to the BZW family. http://togogenome.org/gene/8083:slc52a3 ^@ http://purl.uniprot.org/uniprot/M4AAW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/8083:LOC102224374 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3N3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Nematocyst|||Target cell membrane http://togogenome.org/gene/8083:ipo9 ^@ http://purl.uniprot.org/uniprot/M3ZV04 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:mapre1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/8083:LOC102236826 ^@ http://purl.uniprot.org/uniprot/M4AA92 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8083:LOC102227378 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q559 ^@ Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Lipid droplet http://togogenome.org/gene/8083:LOC102237013 ^@ http://purl.uniprot.org/uniprot/M4AQR8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Endosome|||Heterooligomeric complex.|||Membrane http://togogenome.org/gene/8083:LOC102231514 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane|||Membrane raft http://togogenome.org/gene/8083:arap1 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBW4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:LOC102221286 ^@ http://purl.uniprot.org/uniprot/A0A3B5QD20 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/8083:rhbdf2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QDW3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. http://togogenome.org/gene/8083:LOC102231855 ^@ http://purl.uniprot.org/uniprot/M3ZMX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/8083:LOC102237816 ^@ http://purl.uniprot.org/uniprot/M4A3W7 ^@ Similarity|||Subunit ^@ Belongs to the 14-3-3 family.|||Homodimer, and heterodimer with other family members. http://togogenome.org/gene/8083:tbxas1 ^@ http://purl.uniprot.org/uniprot/M3ZU43 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:dhrs7 ^@ http://purl.uniprot.org/uniprot/M4AGD1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:LOC102216690 ^@ http://purl.uniprot.org/uniprot/M4ABZ3 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/8083:LOC102227242 ^@ http://purl.uniprot.org/uniprot/M3ZUT8 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/8083:pter ^@ http://purl.uniprot.org/uniprot/M4AI51 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.|||Binds 2 divalent metal cations per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:ndufa7 ^@ http://purl.uniprot.org/uniprot/M3ZWB7 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA7 subunit family.|||Complex I is composed of 45 different subunits. http://togogenome.org/gene/8083:LOC102233866 ^@ http://purl.uniprot.org/uniprot/M4ASH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/8083:LOC102234370 ^@ http://purl.uniprot.org/uniprot/A0A3B5QYM0 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/8083:trmt2b ^@ http://purl.uniprot.org/uniprot/A0A3B5QMN8 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102218802 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUS9|||http://purl.uniprot.org/uniprot/M3ZEK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/8083:LOC102223129 ^@ http://purl.uniprot.org/uniprot/A0A3B5QV91 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||gap junction http://togogenome.org/gene/8083:LOC102230612 ^@ http://purl.uniprot.org/uniprot/M4AS58 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/8083:LOC102233864 ^@ http://purl.uniprot.org/uniprot/A0A3B5QTS1 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:tamm41 ^@ http://purl.uniprot.org/uniprot/M4ASK4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAM41 family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:nkx2-5 ^@ http://purl.uniprot.org/uniprot/M4A741 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102219299 ^@ http://purl.uniprot.org/uniprot/M4A469 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM151 family.|||Membrane http://togogenome.org/gene/8083:LOC102233234 ^@ http://purl.uniprot.org/uniprot/M3ZHN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/8083:LOC102227303 ^@ http://purl.uniprot.org/uniprot/M4AH30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/8083:rbp7 ^@ http://purl.uniprot.org/uniprot/M4AAQ1 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8083:hgfac ^@ http://purl.uniprot.org/uniprot/M4AN36 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular space http://togogenome.org/gene/8083:LOC102226984 ^@ http://purl.uniprot.org/uniprot/M3ZYC0 ^@ Similarity ^@ Belongs to the FRAS1 family. http://togogenome.org/gene/8083:ogfod1 ^@ http://purl.uniprot.org/uniprot/M4AI93 ^@ Similarity ^@ Belongs to the TPA1 family. http://togogenome.org/gene/8083:pparg ^@ http://purl.uniprot.org/uniprot/A0A3B5R7R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/8083:six4 ^@ http://purl.uniprot.org/uniprot/M4AGB4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102236833 ^@ http://purl.uniprot.org/uniprot/A0A3B5RE58 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. http://togogenome.org/gene/8083:pds5b ^@ http://purl.uniprot.org/uniprot/M4A227 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102221845 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1A9 ^@ Function|||Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. http://togogenome.org/gene/8083:LOC102233490 ^@ http://purl.uniprot.org/uniprot/A0A3B5PV18 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/8083:uck1 ^@ http://purl.uniprot.org/uniprot/M3ZU20 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/8083:LOC102219566 ^@ http://purl.uniprot.org/uniprot/M4ACI3 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. http://togogenome.org/gene/8083:LOC102235539 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9R7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Membrane|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. http://togogenome.org/gene/8083:chrna7 ^@ http://purl.uniprot.org/uniprot/M3ZE76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:lmod3 ^@ http://purl.uniprot.org/uniprot/M4APR1 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/8083:txnl4a ^@ http://purl.uniprot.org/uniprot/A0A3B5QY17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/8083:LOC102218968 ^@ http://purl.uniprot.org/uniprot/M4AFE9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102217403 ^@ http://purl.uniprot.org/uniprot/M4AI87 ^@ Function|||Similarity|||Subunit ^@ Belongs to the casein kinase 2 subunit beta family.|||Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/8083:LOC102227465 ^@ http://purl.uniprot.org/uniprot/M3ZPF5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/8083:LOC102229086 ^@ http://purl.uniprot.org/uniprot/M4ADZ5 ^@ Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family. http://togogenome.org/gene/8083:LOC102235364 ^@ http://purl.uniprot.org/uniprot/M4AEG9 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/8083:tbpl1 ^@ http://purl.uniprot.org/uniprot/M3ZQ48 ^@ Similarity ^@ Belongs to the TBP family. http://togogenome.org/gene/8083:LOC102233801 ^@ http://purl.uniprot.org/uniprot/M3ZGE1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102217940 ^@ http://purl.uniprot.org/uniprot/M4AEJ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102226544 ^@ http://purl.uniprot.org/uniprot/M4AM32 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/8083:LOC102234480 ^@ http://purl.uniprot.org/uniprot/A0A3B5REH8 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/8083:LOC102237635 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQ40 ^@ Similarity ^@ Belongs to the FAM219 family. http://togogenome.org/gene/8083:cav2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QT48 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/8083:timm10 ^@ http://purl.uniprot.org/uniprot/M4ATH8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/8083:LOC102228051 ^@ http://purl.uniprot.org/uniprot/M4A8M4 ^@ Similarity ^@ Belongs to the splicing factor SR family. http://togogenome.org/gene/8083:LOC102232964 ^@ http://purl.uniprot.org/uniprot/M4AVZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/8083:rbbp4 ^@ http://purl.uniprot.org/uniprot/M3ZW25 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:cdip1 ^@ http://purl.uniprot.org/uniprot/M3ZD17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/8083:LOC102231535 ^@ http://purl.uniprot.org/uniprot/M4AKR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8083:nrxn1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R9L7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:rps23 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS12 family.|||Rough endoplasmic reticulum http://togogenome.org/gene/8083:trim71 ^@ http://purl.uniprot.org/uniprot/M3ZDU6 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/8083:LOC102231783 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWC1 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/8083:galnt5 ^@ http://purl.uniprot.org/uniprot/M4AA18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:KEG86_p12 ^@ http://purl.uniprot.org/uniprot/B5WZ52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 2 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102228325 ^@ http://purl.uniprot.org/uniprot/M4AVF1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102223423 ^@ http://purl.uniprot.org/uniprot/M3ZK86 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/8083:LOC102217242 ^@ http://purl.uniprot.org/uniprot/M4APJ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.|||Interacts with TAMALIN.|||Membrane http://togogenome.org/gene/8083:LOC102226748 ^@ http://purl.uniprot.org/uniprot/M4A4F3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/8083:dao ^@ http://purl.uniprot.org/uniprot/M4AUW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/8083:LOC102233006 ^@ http://purl.uniprot.org/uniprot/A0A3B5QNM0 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/8083:cdh2 ^@ http://purl.uniprot.org/uniprot/M4AQJ3 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/8083:gna13 ^@ http://purl.uniprot.org/uniprot/A0A3B5QKU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-alpha family. G(12) subfamily.|||Membrane http://togogenome.org/gene/8083:LOC106699971 ^@ http://purl.uniprot.org/uniprot/A0A3B5QNA7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:acap3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QDI9 ^@ Activity Regulation|||Domain|||Function|||Subcellular Location Annotation ^@ Endosome membrane|||GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.|||GTPase-activating protein for the ADP ribosylation factor family.|||PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.|||The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions. http://togogenome.org/gene/8083:LOC102218189 ^@ http://purl.uniprot.org/uniprot/M3ZR09 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZP domain family. ZPC subfamily.|||Cell membrane|||Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.|||Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.|||The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.|||Zona pellucida http://togogenome.org/gene/8083:kcnk1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QV10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Cell membrane|||Cytoplasmic vesicle|||Endosome|||Membrane|||Perikaryon|||Recycling endosome|||Synaptic cell membrane|||Vesicle|||dendrite http://togogenome.org/gene/8083:asna1 ^@ http://purl.uniprot.org/uniprot/M3ZSV1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.|||Belongs to the arsA ATPase family.|||Cytoplasm|||Endoplasmic reticulum|||Homodimer. http://togogenome.org/gene/8083:LOC102221053 ^@ http://purl.uniprot.org/uniprot/A0A3B5R1U7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:prkacb ^@ http://purl.uniprot.org/uniprot/A0A3B5PY48|||http://purl.uniprot.org/uniprot/M4AU34 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/8083:mos ^@ http://purl.uniprot.org/uniprot/M3ZFH8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:LOC102221345 ^@ http://purl.uniprot.org/uniprot/M4AZ32 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:urod ^@ http://purl.uniprot.org/uniprot/M4A9Q3 ^@ Similarity|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Homodimer. http://togogenome.org/gene/8083:LOC102222158 ^@ http://purl.uniprot.org/uniprot/A0A3B5R1K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/8083:LOC102219711 ^@ http://purl.uniprot.org/uniprot/M4ANH6 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL1 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/8083:LOC102235003 ^@ http://purl.uniprot.org/uniprot/M3ZK13 ^@ Similarity ^@ Belongs to the TASOR family. http://togogenome.org/gene/8083:tpp2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QUG2 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/8083:nup58 ^@ http://purl.uniprot.org/uniprot/A0A3B5QP68 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/8083:irak1bp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QM01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRAK1BP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102232715 ^@ http://purl.uniprot.org/uniprot/M4A147 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/8083:klhl40 ^@ http://purl.uniprot.org/uniprot/M4A4S9 ^@ Similarity|||Subcellular Location Annotation ^@ A band|||Belongs to the KLHL40 family.|||I band http://togogenome.org/gene/8083:rnasek ^@ http://purl.uniprot.org/uniprot/M3ZIZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase K family.|||Membrane http://togogenome.org/gene/8083:LOC102221994 ^@ http://purl.uniprot.org/uniprot/A0A3B5QI79 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102231365 ^@ http://purl.uniprot.org/uniprot/M4AHE1 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/8083:snx21 ^@ http://purl.uniprot.org/uniprot/M3ZM81 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Membrane http://togogenome.org/gene/8083:LOC102227354 ^@ http://purl.uniprot.org/uniprot/A0A3B5R748|||http://purl.uniprot.org/uniprot/M4ASE1 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/8083:LOC102231522 ^@ http://purl.uniprot.org/uniprot/M4ATL3 ^@ Subcellular Location Annotation ^@ lamellipodium|||sarcomere http://togogenome.org/gene/8083:aifm1 ^@ http://purl.uniprot.org/uniprot/M4AD36 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase family. http://togogenome.org/gene/8083:LOC102221052 ^@ http://purl.uniprot.org/uniprot/M3ZW87 ^@ Similarity ^@ Belongs to the Rab GDI family. http://togogenome.org/gene/8083:slc9a3r1 ^@ http://purl.uniprot.org/uniprot/M4AAU1 ^@ Function|||Subcellular Location Annotation ^@ Endomembrane system|||Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. http://togogenome.org/gene/8083:LOC102219157 ^@ http://purl.uniprot.org/uniprot/M4B0R3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102236274 ^@ http://purl.uniprot.org/uniprot/M4AQI2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:ppm1g ^@ http://purl.uniprot.org/uniprot/M4AKE7 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/8083:LOC102225279 ^@ http://purl.uniprot.org/uniprot/A0A3B5QBK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Membrane http://togogenome.org/gene/8083:alkal2 ^@ http://purl.uniprot.org/uniprot/M3ZZ79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALKAL family.|||Secreted http://togogenome.org/gene/8083:ctsd ^@ http://purl.uniprot.org/uniprot/M4AVA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Lysosome http://togogenome.org/gene/8083:LOC102229941 ^@ http://purl.uniprot.org/uniprot/M4ARU8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:c23h4orf47 ^@ http://purl.uniprot.org/uniprot/M4A934 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP96 family.|||centrosome http://togogenome.org/gene/8083:acvr1 ^@ http://purl.uniprot.org/uniprot/M4AA68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/8083:pld3 ^@ http://purl.uniprot.org/uniprot/M4AF87 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/8083:abcb1 ^@ http://purl.uniprot.org/uniprot/M3ZX98 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102220519 ^@ http://purl.uniprot.org/uniprot/A0A3B5PSH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:ar ^@ http://purl.uniprot.org/uniprot/A0A3B5QWD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/8083:ficd ^@ http://purl.uniprot.org/uniprot/M4AUQ0 ^@ Similarity ^@ Belongs to the fic family. http://togogenome.org/gene/8083:LOC102217033 ^@ http://purl.uniprot.org/uniprot/M4AIA0 ^@ Function|||Subcellular Location Annotation ^@ Endomembrane system|||Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. http://togogenome.org/gene/8083:LOC102234832 ^@ http://purl.uniprot.org/uniprot/A0A3B5QE01 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:tnfsf12 ^@ http://purl.uniprot.org/uniprot/A0A3B5QA30 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/8083:mllt11 ^@ http://purl.uniprot.org/uniprot/A0A3B5PYZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLLT11 family.|||Nucleus|||centrosome http://togogenome.org/gene/8083:rnf157 ^@ http://purl.uniprot.org/uniprot/A0A3B5QSQ8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin ligase. http://togogenome.org/gene/8083:LOC102221224 ^@ http://purl.uniprot.org/uniprot/M4ATI3 ^@ Function|||Similarity ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs. http://togogenome.org/gene/8083:LOC102223910 ^@ http://purl.uniprot.org/uniprot/M4ACQ8 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/8083:slc24a4 ^@ http://purl.uniprot.org/uniprot/M4ARS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/8083:txnrd2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QNY0 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/8083:LOC102226973 ^@ http://purl.uniprot.org/uniprot/M4AYL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:scarf1 ^@ http://purl.uniprot.org/uniprot/M4A228 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102226183 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0N1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin heavy chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||Membrane|||coated pit http://togogenome.org/gene/8083:ankrd13c ^@ http://purl.uniprot.org/uniprot/A0A3B5QYE4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102228495 ^@ http://purl.uniprot.org/uniprot/M3ZMM7 ^@ Function|||Similarity ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. http://togogenome.org/gene/8083:mpi ^@ http://purl.uniprot.org/uniprot/M4AES9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/8083:fam83c ^@ http://purl.uniprot.org/uniprot/A0A3B5QZY0 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/8083:LOC102233395 ^@ http://purl.uniprot.org/uniprot/M4AW95 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:LOC102235867 ^@ http://purl.uniprot.org/uniprot/A0A3B5R4A0 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/8083:aar2 ^@ http://purl.uniprot.org/uniprot/M4AMA9 ^@ Function|||Similarity ^@ Belongs to the AAR2 family.|||Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. http://togogenome.org/gene/8083:tmem231 ^@ http://purl.uniprot.org/uniprot/M4ANQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM231 family.|||Membrane|||Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.|||cilium membrane http://togogenome.org/gene/8083:nkx6-1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPL8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102216548 ^@ http://purl.uniprot.org/uniprot/A0A3B5PY61 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:arx ^@ http://purl.uniprot.org/uniprot/A0A3B5QKP6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:map2k5 ^@ http://purl.uniprot.org/uniprot/M3ZJM6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:LOC102229253 ^@ http://purl.uniprot.org/uniprot/M4AR57 ^@ Function|||Subcellular Location Annotation ^@ Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:fam83h ^@ http://purl.uniprot.org/uniprot/M3ZME8 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/8083:LOC102219097 ^@ http://purl.uniprot.org/uniprot/M4A8H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/8083:lipg ^@ http://purl.uniprot.org/uniprot/M4A704 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:sntb2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QB98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||Cell junction|||cytoskeleton http://togogenome.org/gene/8083:tp53inp2 ^@ http://purl.uniprot.org/uniprot/A0A3B5R3G9 ^@ Subcellular Location Annotation ^@ PML body|||autophagosome|||cytosol http://togogenome.org/gene/8083:polg ^@ http://purl.uniprot.org/uniprot/M3ZFD0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-A family.|||Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.|||mitochondrion nucleoid http://togogenome.org/gene/8083:LOC102229454 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3D2 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/8083:star ^@ http://purl.uniprot.org/uniprot/M4ALS9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ May interact with TSPO.|||Mitochondrion|||Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. http://togogenome.org/gene/8083:LOC102221741 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDY6 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/8083:LOC102231174 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUS1|||http://purl.uniprot.org/uniprot/A0A3B5RAI8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/8083:dusp1 ^@ http://purl.uniprot.org/uniprot/M4A5D5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/8083:LOC102229608 ^@ http://purl.uniprot.org/uniprot/A0A3B5PSY5 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:LOC102233900 ^@ http://purl.uniprot.org/uniprot/M4ACF7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:LOC102227592 ^@ http://purl.uniprot.org/uniprot/M4AXI7 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by DAG and phorbol esters.|||Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/8083:cga ^@ http://purl.uniprot.org/uniprot/M4A0A3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Heterodimer of an alpha and a beta chain.|||Secreted http://togogenome.org/gene/8083:irf5 ^@ http://purl.uniprot.org/uniprot/M4AF39 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:efna1 ^@ http://purl.uniprot.org/uniprot/M3ZYJ7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:idh1 ^@ http://purl.uniprot.org/uniprot/M3ZYJ4 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/8083:ghsr ^@ http://purl.uniprot.org/uniprot/M4A3X7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102232022 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0U2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:dcaf13 ^@ http://purl.uniprot.org/uniprot/A0A3B5QDQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DCAF13/WDSOF1 family.|||nucleolus http://togogenome.org/gene/8083:LOC102219925 ^@ http://purl.uniprot.org/uniprot/M4AQP6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:vars ^@ http://purl.uniprot.org/uniprot/M4A940 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/8083:LOC102230741 ^@ http://purl.uniprot.org/uniprot/A0A3B5QFI4 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/8083:LOC102227260 ^@ http://purl.uniprot.org/uniprot/M4A4G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/8083:lgmn ^@ http://purl.uniprot.org/uniprot/A0A3B5RDC3 ^@ Similarity ^@ Belongs to the peptidase C13 family. http://togogenome.org/gene/8083:trappc4 ^@ http://purl.uniprot.org/uniprot/M3ZFY0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/8083:zc3h12d ^@ http://purl.uniprot.org/uniprot/M3ZS32 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/8083:yes1 ^@ http://purl.uniprot.org/uniprot/M3ZJ39 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/8083:bloc1s3 ^@ http://purl.uniprot.org/uniprot/A0A3B5R4D9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BLOC1S3 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).|||Cytoplasm http://togogenome.org/gene/8083:LOC102228068 ^@ http://purl.uniprot.org/uniprot/M3ZD81 ^@ Caution|||Similarity ^@ Belongs to the globin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:aars ^@ http://purl.uniprot.org/uniprot/M3ZVT8 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Monomer. Interacts with ANKRD16; the interaction is direct. http://togogenome.org/gene/8083:LOC102228369 ^@ http://purl.uniprot.org/uniprot/M4ATV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/8083:LOC102224746 ^@ http://purl.uniprot.org/uniprot/M4ABL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/8083:LOC102221922 ^@ http://purl.uniprot.org/uniprot/M3ZFE8 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/8083:LOC102224820 ^@ http://purl.uniprot.org/uniprot/M4AD91 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:hs2st1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R0Q7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 3 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:LOC102232877 ^@ http://purl.uniprot.org/uniprot/A0A3B5PR01 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rieske iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Membrane|||Mitochondrion inner membrane|||The Rieske protein is a high potential 2Fe-2S protein. http://togogenome.org/gene/8083:edc3 ^@ http://purl.uniprot.org/uniprot/M3ZYW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EDC3 family.|||P-body http://togogenome.org/gene/8083:stra6 ^@ http://purl.uniprot.org/uniprot/M4AN84 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:tpst1 ^@ http://purl.uniprot.org/uniprot/M4A0B3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein sulfotransferase family.|||Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.|||Golgi apparatus membrane http://togogenome.org/gene/8083:lss ^@ http://purl.uniprot.org/uniprot/M3ZW92 ^@ Similarity ^@ Belongs to the terpene cyclase/mutase family. http://togogenome.org/gene/8083:LOC102224253 ^@ http://purl.uniprot.org/uniprot/M4AR78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/8083:LOC102228901 ^@ http://purl.uniprot.org/uniprot/M3ZE78 ^@ Similarity ^@ Belongs to the gamma-glutamyltransferase family. http://togogenome.org/gene/8083:ngdn ^@ http://purl.uniprot.org/uniprot/M3ZVJ0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/8083:LOC102231191 ^@ http://purl.uniprot.org/uniprot/M4AA43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/8083:spdya ^@ http://purl.uniprot.org/uniprot/M4AVE3 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/8083:qars ^@ http://purl.uniprot.org/uniprot/M4AND0 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/8083:ttc4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAL4 ^@ Similarity ^@ Belongs to the TTC4 family. http://togogenome.org/gene/8083:LOC102217440 ^@ http://purl.uniprot.org/uniprot/A0A3B5R961 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ninjurin family.|||Membrane http://togogenome.org/gene/8083:LOC102225342 ^@ http://purl.uniprot.org/uniprot/M4ARP1 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/8083:fam171a2 ^@ http://purl.uniprot.org/uniprot/M4ARA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM171 family.|||Membrane http://togogenome.org/gene/8083:LOC102234616 ^@ http://purl.uniprot.org/uniprot/M4ASQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/8083:LOC102238313 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBX6 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/8083:eif2b5 ^@ http://purl.uniprot.org/uniprot/M3ZDM6 ^@ Similarity ^@ Belongs to the eIF-2B gamma/epsilon subunits family. http://togogenome.org/gene/8083:nid1 ^@ http://purl.uniprot.org/uniprot/M3ZWW7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/8083:LOC102236830 ^@ http://purl.uniprot.org/uniprot/M4AQJ0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/8083:serpind1 ^@ http://purl.uniprot.org/uniprot/M4AIW0 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8083:LOC102234317 ^@ http://purl.uniprot.org/uniprot/M4B0C3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:serpinh1 ^@ http://purl.uniprot.org/uniprot/M3ZGM2 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8083:nacc1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q342 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:ralyl ^@ http://purl.uniprot.org/uniprot/A0A3B5PX44 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/8083:LOC102226689 ^@ http://purl.uniprot.org/uniprot/M4AP31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XRCC4 subfamily.|||Nucleus http://togogenome.org/gene/8083:LOC102227458 ^@ http://purl.uniprot.org/uniprot/A0A3B5QP19 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:cdc25b ^@ http://purl.uniprot.org/uniprot/M3ZU80 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/8083:pex14 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q7Q7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-14 family.|||Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.|||Peroxisome membrane http://togogenome.org/gene/8083:tmed2 ^@ http://purl.uniprot.org/uniprot/M3ZQG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/8083:nubpl ^@ http://purl.uniprot.org/uniprot/M4A4U7 ^@ Similarity ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. http://togogenome.org/gene/8083:pygl ^@ http://purl.uniprot.org/uniprot/M4AKE4 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/8083:LOC102221855 ^@ http://purl.uniprot.org/uniprot/A0A3B5QG41 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102230957 ^@ http://purl.uniprot.org/uniprot/A0A3B5QD30 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/8083:edc4 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat EDC4 family.|||P-body http://togogenome.org/gene/8083:LOC102232739 ^@ http://purl.uniprot.org/uniprot/A0A3B5QJ08 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Cell membrane|||Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:ism1 ^@ http://purl.uniprot.org/uniprot/M3ZVP9 ^@ Similarity ^@ Belongs to the isthmin family. http://togogenome.org/gene/8083:LOC106699661 ^@ http://purl.uniprot.org/uniprot/M3ZUH8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:hadh ^@ http://purl.uniprot.org/uniprot/A0A3B5R5E4 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/8083:LOC102223362 ^@ http://purl.uniprot.org/uniprot/M4AQQ5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular space http://togogenome.org/gene/8083:LOC102229193 ^@ http://purl.uniprot.org/uniprot/M4A7H6 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/8083:mfsd3 ^@ http://purl.uniprot.org/uniprot/M3ZIV1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102228114 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1U1 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/8083:slc46a1 ^@ http://purl.uniprot.org/uniprot/M4A217 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102224700 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUE4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. http://togogenome.org/gene/8083:LOC102226621 ^@ http://purl.uniprot.org/uniprot/M4ABS4 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:pcmt1 ^@ http://purl.uniprot.org/uniprot/M3ZVN2 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/8083:LOC102225343 ^@ http://purl.uniprot.org/uniprot/A0A3B5QP50 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/8083:inha ^@ http://purl.uniprot.org/uniprot/M3ZE64 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.|||Secreted http://togogenome.org/gene/8083:LOC102221872 ^@ http://purl.uniprot.org/uniprot/M4A8C6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8083:LOC102221844 ^@ http://purl.uniprot.org/uniprot/A0A3B5R6X5 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:atg101 ^@ http://purl.uniprot.org/uniprot/M4AHF4 ^@ Similarity ^@ Belongs to the ATG101 family. http://togogenome.org/gene/8083:gnptab ^@ http://purl.uniprot.org/uniprot/M3ZGX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the stealth family.|||Membrane http://togogenome.org/gene/8083:LOC102232225 ^@ http://purl.uniprot.org/uniprot/A0A3B5QVJ9 ^@ Subcellular Location Annotation ^@ Membrane|||Perikaryon|||dendrite http://togogenome.org/gene/8083:LOC102232792 ^@ http://purl.uniprot.org/uniprot/M3ZRG3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/8083:tbr1 ^@ http://purl.uniprot.org/uniprot/M4AAG0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/8083:dhrs7b ^@ http://purl.uniprot.org/uniprot/M4ABP4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:atp5f1c ^@ http://purl.uniprot.org/uniprot/M3ZLG0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/8083:LOC102229242 ^@ http://purl.uniprot.org/uniprot/A0A3B5R4N8 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/8083:fam20b ^@ http://purl.uniprot.org/uniprot/M4AAE0 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/8083:nt5c3a ^@ http://purl.uniprot.org/uniprot/A0A3B5QA71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102219800 ^@ http://purl.uniprot.org/uniprot/A0A3B5QBP1 ^@ Similarity ^@ Belongs to the FAM219 family. http://togogenome.org/gene/8083:bmp3 ^@ http://purl.uniprot.org/uniprot/M4A6B6 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/8083:ppme1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QSS5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the AB hydrolase superfamily.|||Binds PPP2CA and PPP2CB.|||Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. http://togogenome.org/gene/8083:LOC102235314 ^@ http://purl.uniprot.org/uniprot/M3ZPA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/8083:tmem144 ^@ http://purl.uniprot.org/uniprot/M3ZJ04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM144 family.|||Membrane http://togogenome.org/gene/8083:LOC102227238 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWK3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:tomm40 ^@ http://purl.uniprot.org/uniprot/M3ZWS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/8083:ppat ^@ http://purl.uniprot.org/uniprot/A0A3B5R8H6 ^@ Cofactor|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/8083:narfl ^@ http://purl.uniprot.org/uniprot/M4AKV8 ^@ Similarity ^@ Belongs to the NARF family. http://togogenome.org/gene/8083:LOC102222000 ^@ http://purl.uniprot.org/uniprot/A0A3B5R633 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/8083:sh2b2 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q7B7 ^@ Similarity ^@ Belongs to the SH2B adapter family. http://togogenome.org/gene/8083:metap1 ^@ http://purl.uniprot.org/uniprot/M4ALK7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/8083:LOC102221080 ^@ http://purl.uniprot.org/uniprot/M4ABT5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:efhc1 ^@ http://purl.uniprot.org/uniprot/M3ZMG3 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/8083:nme5 ^@ http://purl.uniprot.org/uniprot/M4A3C9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||Cytoplasm|||Major role in the synthesis of nucleoside triphosphates other than ATP.|||Nucleus|||lamellipodium|||ruffle http://togogenome.org/gene/8083:LOC102221877 ^@ http://purl.uniprot.org/uniprot/M3ZMV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes small subunit family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. http://togogenome.org/gene/8083:arcn1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PPB5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/8083:LOC102235038 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVC1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102232321 ^@ http://purl.uniprot.org/uniprot/M3ZKT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:timm9 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGH6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/8083:LOC102225619 ^@ http://purl.uniprot.org/uniprot/A0A3B5QP08 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LIS1/nudF family.|||Can self-associate. Component of the cytosolic PAF-AH (I) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity (By similarity). Interacts with dynein, dynactin, nde1 and ndel1.|||Can self-associate. Interacts with dynein, dynactin, NDE1 and NDEL1.|||Dimerization mediated by the LisH domain may be required to activate dynein.|||Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.|||centrosome|||cytoskeleton http://togogenome.org/gene/8083:LOC102223430 ^@ http://purl.uniprot.org/uniprot/M4A727 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/8083:LOC102228498 ^@ http://purl.uniprot.org/uniprot/M4A257 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/8083:mdk ^@ http://purl.uniprot.org/uniprot/M3ZX66 ^@ Similarity ^@ Belongs to the pleiotrophin family. http://togogenome.org/gene/8083:tmem11 ^@ http://purl.uniprot.org/uniprot/M4ABN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM11 family.|||Membrane|||Plays a role in mitochondrial morphogenesis. http://togogenome.org/gene/8083:bsg ^@ http://purl.uniprot.org/uniprot/A0A3B5PQC6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:anxa1 ^@ http://purl.uniprot.org/uniprot/M3ZIU9 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/8083:LOC102232520 ^@ http://purl.uniprot.org/uniprot/M3ZTW6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family.|||Homotrimer.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/8083:LOC102233260 ^@ http://purl.uniprot.org/uniprot/A0A3B5R763 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:cpvl ^@ http://purl.uniprot.org/uniprot/A0A3B5QSL8 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/8083:LOC102233397 ^@ http://purl.uniprot.org/uniprot/M3ZID7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/8083:eif1ad ^@ http://purl.uniprot.org/uniprot/A0A3B5Q6P6 ^@ Similarity ^@ Belongs to the EIF1AD family. http://togogenome.org/gene/8083:hal ^@ http://purl.uniprot.org/uniprot/M4AQQ0 ^@ Similarity ^@ Belongs to the PAL/histidase family. http://togogenome.org/gene/8083:LOC102216456 ^@ http://purl.uniprot.org/uniprot/M4A5N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSG1 family.|||Membrane http://togogenome.org/gene/8083:LOC102223226 ^@ http://purl.uniprot.org/uniprot/A0A3B5R971 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/8083:itpa ^@ http://purl.uniprot.org/uniprot/M4AA32 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Cytoplasm|||Homodimer.|||Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. http://togogenome.org/gene/8083:imp3 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q5J0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/8083:coq7 ^@ http://purl.uniprot.org/uniprot/M3ZRS4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ7 family.|||Binds 2 iron ions per subunit.|||Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:crcp ^@ http://purl.uniprot.org/uniprot/A0A3B5QS18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC9 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/8083:tmed6 ^@ http://purl.uniprot.org/uniprot/M4A547 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:camsap3 ^@ http://purl.uniprot.org/uniprot/M3ZJP2 ^@ Domain|||Similarity ^@ Belongs to the CAMSAP1 family.|||The CKK domain binds microtubules. http://togogenome.org/gene/8083:cenph ^@ http://purl.uniprot.org/uniprot/M3ZY84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-H/MCM16 family.|||Nucleus|||kinetochore http://togogenome.org/gene/8083:ndufs5 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAS5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS5 subunit family.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102234700 ^@ http://purl.uniprot.org/uniprot/M4A3V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/8083:acaa2 ^@ http://purl.uniprot.org/uniprot/M4AJH0 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/8083:ak5 ^@ http://purl.uniprot.org/uniprot/M4APK0 ^@ Similarity ^@ Belongs to the adenylate kinase family. http://togogenome.org/gene/8083:LOC102232222 ^@ http://purl.uniprot.org/uniprot/M4AYG6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:engase ^@ http://purl.uniprot.org/uniprot/M3ZMM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 85 family.|||cytosol http://togogenome.org/gene/8083:LOC102231237 ^@ http://purl.uniprot.org/uniprot/M4AG05 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:stk17b ^@ http://purl.uniprot.org/uniprot/A0A3B5R9K8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:LOC102226132 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q2W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:fbxo46 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7J6 ^@ Function ^@ Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. http://togogenome.org/gene/8083:yae1d1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QJ88 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102223988 ^@ http://purl.uniprot.org/uniprot/A0A3B5PWD1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/8083:rab38 ^@ http://purl.uniprot.org/uniprot/M4A9Y1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/8083:nexmif ^@ http://purl.uniprot.org/uniprot/A0A3B5R084 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102229234 ^@ http://purl.uniprot.org/uniprot/M3ZP41 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:mettl11b ^@ http://purl.uniprot.org/uniprot/A0A3B5R224 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/8083:LOC102236902 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQN7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102225453 ^@ http://purl.uniprot.org/uniprot/M3ZQZ8 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/8083:zdhhc21 ^@ http://purl.uniprot.org/uniprot/M4A252 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/8083:LOC102226643 ^@ http://purl.uniprot.org/uniprot/M4B118 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/8083:tm7sf2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QI22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/8083:smug1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PT21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.|||Nucleus http://togogenome.org/gene/8083:asl ^@ http://purl.uniprot.org/uniprot/A0A3B5R9H8 ^@ Similarity ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. http://togogenome.org/gene/8083:LOC102226874 ^@ http://purl.uniprot.org/uniprot/M4AZW4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:primpol ^@ http://purl.uniprot.org/uniprot/M3ZTS9 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/8083:LOC102217049 ^@ http://purl.uniprot.org/uniprot/M4A3Y6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:tmem33 ^@ http://purl.uniprot.org/uniprot/M3ZIK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/8083:LOC102228100 ^@ http://purl.uniprot.org/uniprot/M4A6X0 ^@ Similarity ^@ Belongs to the IFI44 family. http://togogenome.org/gene/8083:taf2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF2 family.|||Nucleus http://togogenome.org/gene/8083:mrpl34 ^@ http://purl.uniprot.org/uniprot/A0A3B5QKH1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/8083:LOC106699824 ^@ http://purl.uniprot.org/uniprot/M4A9K5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:LOC102234367 ^@ http://purl.uniprot.org/uniprot/M4AV26 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/8083:lamtor2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QSY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAMAD family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/8083:bckdha ^@ http://purl.uniprot.org/uniprot/M3ZZN7 ^@ Function|||Similarity ^@ Belongs to the BCKDHA family.|||The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/8083:timm44 ^@ http://purl.uniprot.org/uniprot/M4AVT3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tim44 family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102234024 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUE9 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/8083:LOC102231441 ^@ http://purl.uniprot.org/uniprot/A0A3B5PRG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102225655 ^@ http://purl.uniprot.org/uniprot/M3ZGM8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/8083:abcc5 ^@ http://purl.uniprot.org/uniprot/M4AI50 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102220498 ^@ http://purl.uniprot.org/uniprot/M4ALG6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:pacsin1 ^@ http://purl.uniprot.org/uniprot/M4AQ78 ^@ Subcellular Location Annotation ^@ Cell membrane|||Cell projection|||Cytoplasm|||Membrane http://togogenome.org/gene/8083:LOC102233562 ^@ http://purl.uniprot.org/uniprot/A0A3B5QEJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STOP family.|||cytoskeleton http://togogenome.org/gene/8083:stx4 ^@ http://purl.uniprot.org/uniprot/M4AKA9 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/8083:LOC102230496 ^@ http://purl.uniprot.org/uniprot/M4AI61 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/8083:LOC102219543 ^@ http://purl.uniprot.org/uniprot/M3ZYY8 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/8083:LOC102227328 ^@ http://purl.uniprot.org/uniprot/M4AXF2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102234399 ^@ http://purl.uniprot.org/uniprot/A0A3B5QJS6 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/8083:LOC102231340 ^@ http://purl.uniprot.org/uniprot/M3ZTZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/8083:LOC102232085 ^@ http://purl.uniprot.org/uniprot/M3ZN70 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/8083:itfg1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVY0 ^@ Similarity ^@ Belongs to the TIP family. http://togogenome.org/gene/8083:lipt1 ^@ http://purl.uniprot.org/uniprot/M3ZFM2 ^@ Similarity ^@ Belongs to the LplA family. http://togogenome.org/gene/8083:atpaf2 ^@ http://purl.uniprot.org/uniprot/M3ZD69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP12 family.|||Mitochondrion http://togogenome.org/gene/8083:degs2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QNA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:pgm2l1 ^@ http://purl.uniprot.org/uniprot/M4AF42 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/8083:LOC102220264 ^@ http://purl.uniprot.org/uniprot/A0A3B5PRL7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Nematocyst|||Target cell membrane http://togogenome.org/gene/8083:drd2 ^@ http://purl.uniprot.org/uniprot/M4A3B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102233354 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q712 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:LOC102234306 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q7N7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC106699822 ^@ http://purl.uniprot.org/uniprot/M4A1U5 ^@ Similarity ^@ Belongs to the ADP-ribosyl cyclase family. http://togogenome.org/gene/8083:f3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QW52 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tissue factor family.|||Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.|||Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. http://togogenome.org/gene/8083:cyfip1 ^@ http://purl.uniprot.org/uniprot/M4ANU6 ^@ Similarity ^@ Belongs to the CYFIP family. http://togogenome.org/gene/8083:nim1k ^@ http://purl.uniprot.org/uniprot/M4AND2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:LOC102233826 ^@ http://purl.uniprot.org/uniprot/A0A3B5R376 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:tmem2 ^@ http://purl.uniprot.org/uniprot/M3ZGH4 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/8083:LOC102217050 ^@ http://purl.uniprot.org/uniprot/M4A2R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102236835 ^@ http://purl.uniprot.org/uniprot/M3ZGS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:mipep ^@ http://purl.uniprot.org/uniprot/M3ZG53 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/8083:mvb12a ^@ http://purl.uniprot.org/uniprot/M4AC07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MVB12 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/8083:LOC102224107 ^@ http://purl.uniprot.org/uniprot/M4AGE8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.|||Membrane|||The cofactor is mostly bound to the substrate. http://togogenome.org/gene/8083:LOC102225749 ^@ http://purl.uniprot.org/uniprot/M3ZMY5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8083:LOC102219294 ^@ http://purl.uniprot.org/uniprot/A0A3B5RFI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial Rho GTPase family.|||Membrane|||Mitochondrial GTPase involved in mitochondrial trafficking.|||Mitochondrion outer membrane http://togogenome.org/gene/8083:sez6 ^@ http://purl.uniprot.org/uniprot/M3ZED0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102237480 ^@ http://purl.uniprot.org/uniprot/M3ZLM3 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/8083:psmg1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWL3 ^@ Similarity ^@ Belongs to the PSMG1 family. http://togogenome.org/gene/8083:spc24 ^@ http://purl.uniprot.org/uniprot/M3ZQJ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC24 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/8083:LOC102228125 ^@ http://purl.uniprot.org/uniprot/M4AII2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:LOC102234039 ^@ http://purl.uniprot.org/uniprot/A0A3B5QUC7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:polr3k ^@ http://purl.uniprot.org/uniprot/A0A3B5R9M4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/8083:LOC102226341 ^@ http://purl.uniprot.org/uniprot/M4A2K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:lix1l ^@ http://purl.uniprot.org/uniprot/M3ZNI7 ^@ Similarity ^@ Belongs to the LIX1 family. http://togogenome.org/gene/8083:LOC102226936 ^@ http://purl.uniprot.org/uniprot/M3ZWC7 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/8083:zhx2 ^@ http://purl.uniprot.org/uniprot/M4A3I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/8083:LOC102227478 ^@ http://purl.uniprot.org/uniprot/M3ZDP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Rieske iron-sulfur protein family.|||Membrane http://togogenome.org/gene/8083:cdpf1 ^@ http://purl.uniprot.org/uniprot/M3ZQ47 ^@ Similarity ^@ Belongs to the CDPF1 family. http://togogenome.org/gene/8083:fdxr ^@ http://purl.uniprot.org/uniprot/M4AE54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferredoxin--NADP reductase type 1 family.|||Mitochondrion|||Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. http://togogenome.org/gene/8083:bace1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Endosome|||Membrane|||Membrane raft|||Recycling endosome|||trans-Golgi network http://togogenome.org/gene/8083:LOC102236436 ^@ http://purl.uniprot.org/uniprot/M4A7H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/8083:LOC102224822 ^@ http://purl.uniprot.org/uniprot/A0A3B5REF6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:sdhaf1 ^@ http://purl.uniprot.org/uniprot/M4AZN8 ^@ Similarity ^@ Belongs to the complex I LYR family. SDHAF1 subfamily. http://togogenome.org/gene/8083:LOC102229689 ^@ http://purl.uniprot.org/uniprot/A0A3B5QX32 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8083:LOC102230326 ^@ http://purl.uniprot.org/uniprot/M3ZUZ9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:LOC102237740 ^@ http://purl.uniprot.org/uniprot/M4AFZ6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:vps37b ^@ http://purl.uniprot.org/uniprot/A0A3B5Q4I5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/8083:LOC102221575 ^@ http://purl.uniprot.org/uniprot/M3ZPV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. http://togogenome.org/gene/8083:crk ^@ http://purl.uniprot.org/uniprot/M3ZJQ4 ^@ Similarity ^@ Belongs to the CRK family. http://togogenome.org/gene/8083:LOC102222010 ^@ http://purl.uniprot.org/uniprot/M4AJD4 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/8083:fez1 ^@ http://purl.uniprot.org/uniprot/M3ZV65 ^@ Similarity ^@ Belongs to the zygin family. http://togogenome.org/gene/8083:nppc ^@ http://purl.uniprot.org/uniprot/M3ZUQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Secreted http://togogenome.org/gene/8083:LOC102236819 ^@ http://purl.uniprot.org/uniprot/M4AZG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:immp1l ^@ http://purl.uniprot.org/uniprot/M4AIN4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102220339 ^@ http://purl.uniprot.org/uniprot/M4A028 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAPRTase family.|||Cytoplasm|||Homodimer.|||Nucleus|||Secreted http://togogenome.org/gene/8083:LOC102216469 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGS7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102229161 ^@ http://purl.uniprot.org/uniprot/M3ZJP6 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/8083:mb21d2 ^@ http://purl.uniprot.org/uniprot/M4AJX7 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/8083:LOC102224335 ^@ http://purl.uniprot.org/uniprot/M3ZDM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102230501 ^@ http://purl.uniprot.org/uniprot/M4AFA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/8083:LOC102226599 ^@ http://purl.uniprot.org/uniprot/M4AXN4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the importin beta family.|||Cytoplasm|||Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.|||Nucleus http://togogenome.org/gene/8083:fscn2 ^@ http://purl.uniprot.org/uniprot/A0A3B5RCB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/8083:neurl2 ^@ http://purl.uniprot.org/uniprot/M3ZD49 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:jagn1 ^@ http://purl.uniprot.org/uniprot/M4A671 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the jagunal family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102227985 ^@ http://purl.uniprot.org/uniprot/A0A3B5R204 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/8083:LOC102219657 ^@ http://purl.uniprot.org/uniprot/A0A3B5QML4 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.|||Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. http://togogenome.org/gene/8083:cadm4 ^@ http://purl.uniprot.org/uniprot/A0A3B5PZ13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nectin family.|||Membrane http://togogenome.org/gene/8083:smarcd1 ^@ http://purl.uniprot.org/uniprot/M4A7I4 ^@ Similarity ^@ Belongs to the SMARCD family. http://togogenome.org/gene/8083:slc25a22 ^@ http://purl.uniprot.org/uniprot/M3ZNQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:cdc73 ^@ http://purl.uniprot.org/uniprot/M3ZRI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC73 family.|||Nucleus http://togogenome.org/gene/8083:lin52 ^@ http://purl.uniprot.org/uniprot/A0A3B5QA29 ^@ Similarity ^@ Belongs to the lin-52 family. http://togogenome.org/gene/8083:LOC102224349 ^@ http://purl.uniprot.org/uniprot/M4ABU6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:cenpn ^@ http://purl.uniprot.org/uniprot/M3ZLP5 ^@ Similarity ^@ Belongs to the CENP-N/CHL4 family. http://togogenome.org/gene/8083:LOC102233543 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q943 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102224648 ^@ http://purl.uniprot.org/uniprot/M3ZU04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:LOC102234446 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHD8 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family. http://togogenome.org/gene/8083:syn2 ^@ http://purl.uniprot.org/uniprot/M4ASH5 ^@ Similarity ^@ Belongs to the synapsin family. http://togogenome.org/gene/8083:LOC102231568 ^@ http://purl.uniprot.org/uniprot/A0A3B5QB42|||http://purl.uniprot.org/uniprot/M4A3Y5 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/8083:crot ^@ http://purl.uniprot.org/uniprot/M3ZX04 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/8083:LOC102225276 ^@ http://purl.uniprot.org/uniprot/A0A3B5QDK3 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/8083:sec61b ^@ http://purl.uniprot.org/uniprot/A0A3B5QME6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Endoplasmic reticulum membrane|||Membrane|||Necessary for protein translocation in the endoplasmic reticulum. http://togogenome.org/gene/8083:ntmt1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQE4 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/8083:LOC102224095 ^@ http://purl.uniprot.org/uniprot/A0A3B5R787 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/8083:LOC102234935 ^@ http://purl.uniprot.org/uniprot/A0A3B5QT32 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||May be an activator of the JNK/SAPK pathway. http://togogenome.org/gene/8083:LOC102233658 ^@ http://purl.uniprot.org/uniprot/M3ZW39 ^@ Subcellular Location Annotation ^@ centrosome|||perinuclear region http://togogenome.org/gene/8083:tsnax ^@ http://purl.uniprot.org/uniprot/M3ZX09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the translin family.|||Nucleus http://togogenome.org/gene/8083:LOC102220506 ^@ http://purl.uniprot.org/uniprot/M4APV8 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/8083:sord ^@ http://purl.uniprot.org/uniprot/M3ZYM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the zinc-containing alcohol dehydrogenase family.|||Mitochondrion membrane|||flagellum http://togogenome.org/gene/8083:rag1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QA24 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RAG1 family.|||Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).|||Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.|||Homodimer.|||Nucleus|||The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp. http://togogenome.org/gene/8083:LOC102217478 ^@ http://purl.uniprot.org/uniprot/M4AWF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCF family.|||Cytoplasm|||Secreted|||filopodium|||lamellipodium http://togogenome.org/gene/8083:ccbe1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R3T4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102217201 ^@ http://purl.uniprot.org/uniprot/M3ZL73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 6A family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:taz ^@ http://purl.uniprot.org/uniprot/M3ZDH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the taffazin family.|||Mitochondrion inner membrane|||Mitochondrion outer membrane http://togogenome.org/gene/8083:ppp2r3c ^@ http://purl.uniprot.org/uniprot/M4A4K4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:snupn ^@ http://purl.uniprot.org/uniprot/M3ZWS2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snurportin family.|||Cytoplasm|||Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.|||Nucleus http://togogenome.org/gene/8083:oxsm ^@ http://purl.uniprot.org/uniprot/M4AR48 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/8083:LOC102235929 ^@ http://purl.uniprot.org/uniprot/A0A3B5QBY7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CNRIP family.|||Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.|||Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. http://togogenome.org/gene/8083:nup210 ^@ http://purl.uniprot.org/uniprot/A0A3B5QXP1 ^@ Similarity ^@ Belongs to the NUP210 family. http://togogenome.org/gene/8083:vps33b ^@ http://purl.uniprot.org/uniprot/M4AUK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/8083:rtraf ^@ http://purl.uniprot.org/uniprot/A0A3B5QVY1 ^@ Similarity ^@ Belongs to the RTRAF family. http://togogenome.org/gene/8083:pigh ^@ http://purl.uniprot.org/uniprot/M3ZX75 ^@ Similarity ^@ Belongs to the PIGH family. http://togogenome.org/gene/8083:eno3 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q293 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/8083:ddost ^@ http://purl.uniprot.org/uniprot/M4AD99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DDOST 48 kDa subunit family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). http://togogenome.org/gene/8083:fgf5 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPL4 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:LOC102225439 ^@ http://purl.uniprot.org/uniprot/A0A3B5REP5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102232743 ^@ http://purl.uniprot.org/uniprot/A0A3B5QTH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:asic4 ^@ http://purl.uniprot.org/uniprot/M3ZN40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:fgf19 ^@ http://purl.uniprot.org/uniprot/M3ZH24 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:LOC102237613 ^@ http://purl.uniprot.org/uniprot/A0A3B5QIE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM263 family.|||Membrane http://togogenome.org/gene/8083:ctps1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QL72 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/8083:lonp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PPN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.|||Belongs to the peptidase S16 family.|||Homohexamer or homoheptamer. Organized in a ring with a central cavity.|||Mitochondrion matrix http://togogenome.org/gene/8083:wdpcp ^@ http://purl.uniprot.org/uniprot/M3ZTR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat fritz family.|||Cell membrane|||Membrane|||cilium axoneme http://togogenome.org/gene/8083:fgf18 ^@ http://purl.uniprot.org/uniprot/A0A3B5QYT7 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:pfdn2 ^@ http://purl.uniprot.org/uniprot/M4AJS5 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/8083:gorab ^@ http://purl.uniprot.org/uniprot/M3ZTB2 ^@ Similarity ^@ Belongs to the GORAB family. http://togogenome.org/gene/8083:LOC102227809 ^@ http://purl.uniprot.org/uniprot/A0A3B5QX97 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/8083:LOC102225297 ^@ http://purl.uniprot.org/uniprot/M4AUY1 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/8083:egr3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QJ98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/8083:hoxa3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QU00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/8083:LOC102229915 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWM9 ^@ Similarity ^@ Belongs to the CELF/BRUNOL family. http://togogenome.org/gene/8083:LOC102226584 ^@ http://purl.uniprot.org/uniprot/M4AKW7 ^@ Function|||Similarity ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs. http://togogenome.org/gene/8083:cckar ^@ http://purl.uniprot.org/uniprot/A0A3B5RC77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:trappc2l ^@ http://purl.uniprot.org/uniprot/M4AWR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/8083:ncan ^@ http://purl.uniprot.org/uniprot/M4ACN5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:pdgfrb ^@ http://purl.uniprot.org/uniprot/M4A2A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102226401 ^@ http://purl.uniprot.org/uniprot/M4AL48 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/8083:LOC102226720 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q547 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102226466 ^@ http://purl.uniprot.org/uniprot/M4A4K1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/8083:LOC102227869 ^@ http://purl.uniprot.org/uniprot/M4B0L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/8083:kcnab1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PST8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/8083:rps3 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q286 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Membrane|||Mitochondrion inner membrane|||spindle http://togogenome.org/gene/8083:xkr9 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/8083:kif22 ^@ http://purl.uniprot.org/uniprot/M4AVX2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/8083:LOC102235332 ^@ http://purl.uniprot.org/uniprot/M4AZC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:tac1 ^@ http://purl.uniprot.org/uniprot/M4AR01 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted|||Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. http://togogenome.org/gene/8083:LOC102220505 ^@ http://purl.uniprot.org/uniprot/M4AQK6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102237020 ^@ http://purl.uniprot.org/uniprot/M4AD67 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/8083:abracl ^@ http://purl.uniprot.org/uniprot/A0A3B5R7Q8 ^@ Similarity ^@ Belongs to the costars family. http://togogenome.org/gene/8083:cdc45 ^@ http://purl.uniprot.org/uniprot/M4AK14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC45 family.|||Nucleus http://togogenome.org/gene/8083:stxbp3 ^@ http://purl.uniprot.org/uniprot/M3ZED1 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/8083:LOC102234450 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0X4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LEAP2 family.|||Has an antimicrobial activity.|||Secreted http://togogenome.org/gene/8083:LOC102233669 ^@ http://purl.uniprot.org/uniprot/A0A3B5R3F0 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/8083:LOC102229755 ^@ http://purl.uniprot.org/uniprot/M3ZW53 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:mrps26 ^@ http://purl.uniprot.org/uniprot/A0A3B5QEH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS26 family.|||Mitochondrion http://togogenome.org/gene/8083:LOC102238293 ^@ http://purl.uniprot.org/uniprot/A0A3B5QMS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:prlr ^@ http://purl.uniprot.org/uniprot/M3ZQ18 ^@ Similarity ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily. http://togogenome.org/gene/8083:LOC102235930 ^@ http://purl.uniprot.org/uniprot/M4AIY6 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/8083:LOC102216911 ^@ http://purl.uniprot.org/uniprot/M4AVZ5 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/8083:sec63 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q6N5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:wnt11 ^@ http://purl.uniprot.org/uniprot/M4AHH6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/8083:ptprn2 ^@ http://purl.uniprot.org/uniprot/M3ZJM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.|||Membrane|||secretory vesicle membrane http://togogenome.org/gene/8083:LOC102219366 ^@ http://purl.uniprot.org/uniprot/M4ATE5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102229837 ^@ http://purl.uniprot.org/uniprot/A0A3B5R8Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:hip1r ^@ http://purl.uniprot.org/uniprot/M4ATC9 ^@ Similarity ^@ Belongs to the SLA2 family. http://togogenome.org/gene/8083:LOC102238262 ^@ http://purl.uniprot.org/uniprot/M4A5N6 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/8083:armc9 ^@ http://purl.uniprot.org/uniprot/M3ZUM9 ^@ Subcellular Location Annotation ^@ centriole|||cilium|||cilium basal body http://togogenome.org/gene/8083:pax1 ^@ http://purl.uniprot.org/uniprot/M4AXF5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102227651 ^@ http://purl.uniprot.org/uniprot/A0A3B5RA64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:aqp8 ^@ http://purl.uniprot.org/uniprot/A0A3B5R5B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/8083:snap23 ^@ http://purl.uniprot.org/uniprot/A0A3B5R613 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||synaptosome http://togogenome.org/gene/8083:c2h11orf49 ^@ http://purl.uniprot.org/uniprot/M3ZW45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSTPP1 family.|||cytoskeleton http://togogenome.org/gene/8083:LOC102233363 ^@ http://purl.uniprot.org/uniprot/M4AF47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/8083:map2k1 ^@ http://purl.uniprot.org/uniprot/M3ZMS8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:mpv17l2 ^@ http://purl.uniprot.org/uniprot/M3ZJY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/8083:LOC102226468 ^@ http://purl.uniprot.org/uniprot/M4ART1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102227430 ^@ http://purl.uniprot.org/uniprot/M3ZGK3 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin Y subfamily. http://togogenome.org/gene/8083:ccnh ^@ http://purl.uniprot.org/uniprot/A0A3B5PQY8 ^@ Function|||Similarity|||Subunit ^@ Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.|||Belongs to the cyclin family. Cyclin C subfamily.|||Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. http://togogenome.org/gene/8083:rho ^@ http://purl.uniprot.org/uniprot/M4ASD9 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Contains one covalently linked retinal chromophore.|||Membrane http://togogenome.org/gene/8083:fscn1 ^@ http://purl.uniprot.org/uniprot/M3ZFJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/8083:pdlim3 ^@ http://purl.uniprot.org/uniprot/M4AWX5 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/8083:sdhaf3 ^@ http://purl.uniprot.org/uniprot/M4AR00 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I LYR family. SDHAF3 subfamily.|||Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. http://togogenome.org/gene/8083:rbbp5 ^@ http://purl.uniprot.org/uniprot/M3ZPK7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102231141 ^@ http://purl.uniprot.org/uniprot/M4APT3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.|||Membrane http://togogenome.org/gene/8083:agxt2 ^@ http://purl.uniprot.org/uniprot/A0A3B5R1Y9 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/8083:clptm1 ^@ http://purl.uniprot.org/uniprot/M3ZQ21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLPTM1 family.|||Membrane http://togogenome.org/gene/8083:prickle2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QET9 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/8083:stmn2 ^@ http://purl.uniprot.org/uniprot/M3ZN05 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/8083:ppt1 ^@ http://purl.uniprot.org/uniprot/M3ZMR6 ^@ Similarity ^@ Belongs to the palmitoyl-protein thioesterase family. http://togogenome.org/gene/8083:pik3c2a ^@ http://purl.uniprot.org/uniprot/A0A3B5RDS5 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/8083:LOC102217676 ^@ http://purl.uniprot.org/uniprot/M4AGH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/8083:srp9 ^@ http://purl.uniprot.org/uniprot/A0A3B5PV75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP9 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm http://togogenome.org/gene/8083:fam57a ^@ http://purl.uniprot.org/uniprot/A0A3B5RD63 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102234401 ^@ http://purl.uniprot.org/uniprot/M4A4W0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/8083:LOC102218197 ^@ http://purl.uniprot.org/uniprot/A0A3B5QUW6 ^@ Similarity|||Subunit ^@ Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.|||Homotetramer. http://togogenome.org/gene/8083:tnpo3 ^@ http://purl.uniprot.org/uniprot/M4AF64 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:psat1 ^@ http://purl.uniprot.org/uniprot/M3ZKR0 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.|||Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. http://togogenome.org/gene/8083:rpl31 ^@ http://purl.uniprot.org/uniprot/M4AD93 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL31 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/8083:LOC102218847 ^@ http://purl.uniprot.org/uniprot/M4A984 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:ccdc126 ^@ http://purl.uniprot.org/uniprot/A0A3B5QG90 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/8083:LOC102234756 ^@ http://purl.uniprot.org/uniprot/A0A3B5RD31 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 5A family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102225189 ^@ http://purl.uniprot.org/uniprot/A0A3B5QJI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Membrane|||Midbody|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. http://togogenome.org/gene/8083:acer3 ^@ http://purl.uniprot.org/uniprot/A0A3B5PSQ0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102230632 ^@ http://purl.uniprot.org/uniprot/A0A3B5QFJ0 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/8083:rps4x ^@ http://purl.uniprot.org/uniprot/M4AK76 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/8083:LOC102238326 ^@ http://purl.uniprot.org/uniprot/M3ZTN4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/8083:LOC102230229 ^@ http://purl.uniprot.org/uniprot/M4AK84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/8083:ndufb5 ^@ http://purl.uniprot.org/uniprot/M4AUZ8 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB5 subunit family.|||Complex I is composed of 45 different subunits. http://togogenome.org/gene/8083:trnt1 ^@ http://purl.uniprot.org/uniprot/M3ZJ36 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/8083:copa ^@ http://purl.uniprot.org/uniprot/M3ZTH7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. http://togogenome.org/gene/8083:zdhhc16 ^@ http://purl.uniprot.org/uniprot/A0A3B5QUY2 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/8083:LOC102216437 ^@ http://purl.uniprot.org/uniprot/M3ZL49 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:chst3 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q2W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/8083:aldh1a3 ^@ http://purl.uniprot.org/uniprot/M3ZGN9 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/8083:mknk1 ^@ http://purl.uniprot.org/uniprot/M4AFI1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:lpar3 ^@ http://purl.uniprot.org/uniprot/M4AUI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:rnps1 ^@ http://purl.uniprot.org/uniprot/M3ZRJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the splicing factor SR family.|||Nucleus speckle http://togogenome.org/gene/8083:bmt2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QMP5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the BMT2 family.|||Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.|||S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/8083:LOC102226845 ^@ http://purl.uniprot.org/uniprot/M4AKY1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/8083:sh3pxd2b ^@ http://purl.uniprot.org/uniprot/A0A3B5Q106 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SH3PXD2 family.|||Cytoplasm http://togogenome.org/gene/8083:vezt ^@ http://purl.uniprot.org/uniprot/M4A378 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vezatin family.|||Cell membrane|||Membrane|||Nucleus|||adherens junction http://togogenome.org/gene/8083:gsn ^@ http://purl.uniprot.org/uniprot/A0A3B5QS65 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the villin/gelsolin family.|||Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.|||cytoskeleton http://togogenome.org/gene/8083:LOC102220900 ^@ http://purl.uniprot.org/uniprot/M4ANS5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102233599 ^@ http://purl.uniprot.org/uniprot/M3ZZR9 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/8083:LOC102231982 ^@ http://purl.uniprot.org/uniprot/M4A8M3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/8083:LOC102237230 ^@ http://purl.uniprot.org/uniprot/M3ZR78 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tissue factor family.|||Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.|||Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. http://togogenome.org/gene/8083:LOC102222779 ^@ http://purl.uniprot.org/uniprot/M4A0H7 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/8083:pa2g4 ^@ http://purl.uniprot.org/uniprot/M3ZI85 ^@ Similarity ^@ Belongs to the peptidase M24 family. http://togogenome.org/gene/8083:LOC102228652 ^@ http://purl.uniprot.org/uniprot/M4APF2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. http://togogenome.org/gene/8083:LOC102235034 ^@ http://purl.uniprot.org/uniprot/M3ZIJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:dlat ^@ http://purl.uniprot.org/uniprot/M4A959 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 2 lipoyl cofactors covalently.|||Mitochondrion|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/8083:pxmp2 ^@ http://purl.uniprot.org/uniprot/M4AV05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/8083:LOC102227870 ^@ http://purl.uniprot.org/uniprot/A0A3B5QS95 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/8083:ppp6c ^@ http://purl.uniprot.org/uniprot/M3ZL59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102216641 ^@ http://purl.uniprot.org/uniprot/A0A3B5QW88 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/8083:phykpl ^@ http://purl.uniprot.org/uniprot/M4A3E9 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/8083:LOC102217544 ^@ http://purl.uniprot.org/uniprot/M4ASR2 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102226477 ^@ http://purl.uniprot.org/uniprot/A0A3B5QBR7 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/8083:LOC102226063 ^@ http://purl.uniprot.org/uniprot/A0A3B5R381 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102217772 ^@ http://purl.uniprot.org/uniprot/M4AU46 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:lta4h ^@ http://purl.uniprot.org/uniprot/M3ZL12 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/8083:LOC102235101 ^@ http://purl.uniprot.org/uniprot/A0A3B5PQE1 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/8083:parp6 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHY2 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/8083:lrig3 ^@ http://purl.uniprot.org/uniprot/M4A6W5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:slc6a17 ^@ http://purl.uniprot.org/uniprot/M4A6N8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/8083:LOC102228737 ^@ http://purl.uniprot.org/uniprot/M3ZWP6 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:cog7 ^@ http://purl.uniprot.org/uniprot/M4AX82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG7 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:chpt1 ^@ http://purl.uniprot.org/uniprot/M3ZGZ2 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/8083:cmtm7 ^@ http://purl.uniprot.org/uniprot/A0A3B5R759 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102237697 ^@ http://purl.uniprot.org/uniprot/M3ZJZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/8083:slc26a3 ^@ http://purl.uniprot.org/uniprot/M3ZU81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.|||Membrane http://togogenome.org/gene/8083:pnpla6 ^@ http://purl.uniprot.org/uniprot/A0A3B5QVG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NTE family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102228317 ^@ http://purl.uniprot.org/uniprot/M4AL64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Orai family.|||Membrane http://togogenome.org/gene/8083:LOC102233997 ^@ http://purl.uniprot.org/uniprot/M4A6S6 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/8083:ano10 ^@ http://purl.uniprot.org/uniprot/A0A3B5QH96 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102228622 ^@ http://purl.uniprot.org/uniprot/M4AGG8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:foxb1 ^@ http://purl.uniprot.org/uniprot/M3ZM37 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102230729 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q335 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/8083:LOC102220009 ^@ http://purl.uniprot.org/uniprot/M4ACR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Su(H) family.|||Nucleus http://togogenome.org/gene/8083:laptm4b ^@ http://purl.uniprot.org/uniprot/M3ZM16 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/8083:sec16a ^@ http://purl.uniprot.org/uniprot/A0A3B5REA8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC16 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.|||SEC16A and SEC16B are each present in multiple copies in a heteromeric complex. http://togogenome.org/gene/8083:LOC102220526 ^@ http://purl.uniprot.org/uniprot/M4AQP5 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/8083:strip1 ^@ http://purl.uniprot.org/uniprot/M3ZG69 ^@ Similarity ^@ Belongs to the STRIP family. http://togogenome.org/gene/8083:atp6v0b ^@ http://purl.uniprot.org/uniprot/M4ARH8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||clathrin-coated vesicle membrane http://togogenome.org/gene/8083:calhm1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QFH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/8083:ears2 ^@ http://purl.uniprot.org/uniprot/M4AK90 ^@ Function|||Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). http://togogenome.org/gene/8083:LOC102236041 ^@ http://purl.uniprot.org/uniprot/M4AMI7 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:adamts14 ^@ http://purl.uniprot.org/uniprot/M4AL57 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/8083:lamp1 ^@ http://purl.uniprot.org/uniprot/M4AXY6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/8083:htr2b ^@ http://purl.uniprot.org/uniprot/M3ZTZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||synaptosome http://togogenome.org/gene/8083:LOC102230823 ^@ http://purl.uniprot.org/uniprot/A0A3B5R5E8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the argonaute family.|||P-body http://togogenome.org/gene/8083:LOC102231943 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cytoplasm http://togogenome.org/gene/8083:chmp1b ^@ http://purl.uniprot.org/uniprot/M4ACE1 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/8083:ptger3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QFI5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102218276 ^@ http://purl.uniprot.org/uniprot/M4AM74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102225446 ^@ http://purl.uniprot.org/uniprot/M3ZID7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/8083:LOC102226754 ^@ http://purl.uniprot.org/uniprot/M4ARI1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ROX family.|||Binds 1 Fe(2+) ion per subunit.|||Nucleus|||Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. http://togogenome.org/gene/8083:tmem70 ^@ http://purl.uniprot.org/uniprot/M4AWJ5 ^@ Similarity ^@ Belongs to the TMEM70 family. http://togogenome.org/gene/8083:LOC102224645 ^@ http://purl.uniprot.org/uniprot/M4ARB2 ^@ Function|||Similarity ^@ Belongs to the MON1/SAND family.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/8083:tspan6 ^@ http://purl.uniprot.org/uniprot/M4AGG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:spon1 ^@ http://purl.uniprot.org/uniprot/M3ZXT5 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/8083:ctsa ^@ http://purl.uniprot.org/uniprot/A0A3B5Q6C6 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/8083:LOC102226946 ^@ http://purl.uniprot.org/uniprot/M3ZNF4 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/8083:taf11 ^@ http://purl.uniprot.org/uniprot/M4AQD4 ^@ Similarity ^@ Belongs to the TAF11 family. http://togogenome.org/gene/8083:LOC102219212 ^@ http://purl.uniprot.org/uniprot/M4AJJ6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102228607 ^@ http://purl.uniprot.org/uniprot/A0A3B5PX91 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102218412 ^@ http://purl.uniprot.org/uniprot/M4AUV1 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/8083:LOC102237981 ^@ http://purl.uniprot.org/uniprot/M3ZL45 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:tsfm ^@ http://purl.uniprot.org/uniprot/M4AVL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Mitochondrion http://togogenome.org/gene/8083:LOC102222780 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q069|||http://purl.uniprot.org/uniprot/A0A3B5QED0 ^@ Similarity ^@ Belongs to the RRM IMP/VICKZ family. http://togogenome.org/gene/8083:vgll4 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3A7 ^@ Function|||Similarity ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs. http://togogenome.org/gene/8083:pgm1 ^@ http://purl.uniprot.org/uniprot/M3ZIY8 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/8083:acad8 ^@ http://purl.uniprot.org/uniprot/A0A3B5PP04 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/8083:atp5pf ^@ http://purl.uniprot.org/uniprot/M4ADZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ATPase subunit F6 family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102226081 ^@ http://purl.uniprot.org/uniprot/M4A4M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/8083:LOC102237634 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q7M6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/8083:wars2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZT7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/8083:suclg1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QSJ4|||http://purl.uniprot.org/uniprot/M3ZUU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).|||Mitochondrion|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. http://togogenome.org/gene/8083:chdh ^@ http://purl.uniprot.org/uniprot/M4AXY1 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/8083:arl5b ^@ http://purl.uniprot.org/uniprot/M3ZJA5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/8083:pde1a ^@ http://purl.uniprot.org/uniprot/A0A3B5QH69 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/8083:derl1 ^@ http://purl.uniprot.org/uniprot/M4A3H3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/8083:LOC102224724 ^@ http://purl.uniprot.org/uniprot/M4AY43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:LOC102228171 ^@ http://purl.uniprot.org/uniprot/M4A503 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/8083:tbc1d23 ^@ http://purl.uniprot.org/uniprot/A0A3B5R4V3 ^@ Subcellular Location Annotation ^@ trans-Golgi network http://togogenome.org/gene/8083:LOC102237544 ^@ http://purl.uniprot.org/uniprot/A0A3B5PYL8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:snf8 ^@ http://purl.uniprot.org/uniprot/A0A3B5PWE3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SNF8 family.|||Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II). http://togogenome.org/gene/8083:foxo3 ^@ http://purl.uniprot.org/uniprot/Q90YK2 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/8083:ube2a ^@ http://purl.uniprot.org/uniprot/M4AH01 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:LOC102218540 ^@ http://purl.uniprot.org/uniprot/M4AP75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8083:LOC102235901 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHC9 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/8083:pex6 ^@ http://purl.uniprot.org/uniprot/M3ZUW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||cytosol http://togogenome.org/gene/8083:lpcat2 ^@ http://purl.uniprot.org/uniprot/M4A055 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/8083:lyrm9 ^@ http://purl.uniprot.org/uniprot/A0A3B5R645 ^@ Similarity ^@ Belongs to the complex I LYR family. LYRM9 subfamily. http://togogenome.org/gene/8083:LOC102228771 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q266 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Cell membrane|||Cytoplasmic vesicle|||Endosome|||Membrane|||Perikaryon|||Recycling endosome|||Synaptic cell membrane|||Vesicle|||dendrite http://togogenome.org/gene/8083:LOC102227552 ^@ http://purl.uniprot.org/uniprot/A0A3B5R135 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/8083:rln3 ^@ http://purl.uniprot.org/uniprot/M4AEH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/8083:LOC102237620 ^@ http://purl.uniprot.org/uniprot/M3ZKI1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.|||Membrane|||tight junction http://togogenome.org/gene/8083:fgf3 ^@ http://purl.uniprot.org/uniprot/M3ZH09 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:gpat3 ^@ http://purl.uniprot.org/uniprot/M4ADJ8 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/8083:paqr3 ^@ http://purl.uniprot.org/uniprot/M4A654 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/8083:LOC102224125 ^@ http://purl.uniprot.org/uniprot/M4A6E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the N4BP3 family.|||Vesicle|||dendrite http://togogenome.org/gene/8083:acp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGM8|||http://purl.uniprot.org/uniprot/M3ZZW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.|||Belongs to the low molecular weight phosphotyrosine protein phosphatase family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102217686 ^@ http://purl.uniprot.org/uniprot/M3ZGF0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDH/MDH superfamily. LDH family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/8083:polr3h ^@ http://purl.uniprot.org/uniprot/M3ZXJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/8083:LOC102235607 ^@ http://purl.uniprot.org/uniprot/M3ZHG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ena/VASP family.|||cytoskeleton http://togogenome.org/gene/8083:KEG86_p13 ^@ http://purl.uniprot.org/uniprot/B5WZ51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 1 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:ppp4r2 ^@ http://purl.uniprot.org/uniprot/M3ZRB1 ^@ Similarity ^@ Belongs to the PPP4R2 family. http://togogenome.org/gene/8083:plac8 ^@ http://purl.uniprot.org/uniprot/A0A3B5QH91 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/8083:rab21 ^@ http://purl.uniprot.org/uniprot/M4A7J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cleavage furrow|||Early endosome membrane|||Endoplasmic reticulum membrane|||trans-Golgi network http://togogenome.org/gene/8083:LOC102230146 ^@ http://purl.uniprot.org/uniprot/M3ZFH1 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/8083:mlec ^@ http://purl.uniprot.org/uniprot/M3ZL84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the malectin family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102235344 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8C3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/8083:slc30a8 ^@ http://purl.uniprot.org/uniprot/M4AHX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/8083:c12h9orf78 ^@ http://purl.uniprot.org/uniprot/A0A3B5PQJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TLS1 family.|||Nucleus http://togogenome.org/gene/8083:LOC106700200 ^@ http://purl.uniprot.org/uniprot/M4AGW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/8083:LOC102217754 ^@ http://purl.uniprot.org/uniprot/M4A844 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:chat ^@ http://purl.uniprot.org/uniprot/M3ZLC7 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/8083:ythdf2 ^@ http://purl.uniprot.org/uniprot/M4AWF9 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/8083:cdk7 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQX8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/8083:bri3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QFM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BRI3 family.|||Membrane|||perinuclear region http://togogenome.org/gene/8083:chd2 ^@ http://purl.uniprot.org/uniprot/M3ZKN4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102236740 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7U8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/8083:elavl1 ^@ http://purl.uniprot.org/uniprot/M4A4J0 ^@ Similarity ^@ Belongs to the RRM elav family. http://togogenome.org/gene/8083:LOC102237208 ^@ http://purl.uniprot.org/uniprot/A0A3B5QRI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:amd1 ^@ http://purl.uniprot.org/uniprot/M3ZS91 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic AdoMetDC family.|||Binds 1 pyruvoyl group covalently per subunit.|||Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. http://togogenome.org/gene/8083:LOC102233950 ^@ http://purl.uniprot.org/uniprot/M4A2V2 ^@ Domain|||Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.|||The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. http://togogenome.org/gene/8083:polb ^@ http://purl.uniprot.org/uniprot/Q66TP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Cytoplasm|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/8083:spast ^@ http://purl.uniprot.org/uniprot/M3ZW57 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/8083:lhx1 ^@ http://purl.uniprot.org/uniprot/M3ZT13 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:sh3gl1 ^@ http://purl.uniprot.org/uniprot/M4AF38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Membrane http://togogenome.org/gene/8083:c10h16orf62 ^@ http://purl.uniprot.org/uniprot/M4A5C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS35L family.|||Endosome http://togogenome.org/gene/8083:eif4a2 ^@ http://purl.uniprot.org/uniprot/M3ZQX1 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/8083:dpm1 ^@ http://purl.uniprot.org/uniprot/M3ZW98 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum|||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. http://togogenome.org/gene/8083:slc13a4 ^@ http://purl.uniprot.org/uniprot/M4A358 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/8083:snrpe ^@ http://purl.uniprot.org/uniprot/M4A324 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. http://togogenome.org/gene/8083:aoc1 ^@ http://purl.uniprot.org/uniprot/M3ZT00 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/8083:LOC102227723 ^@ http://purl.uniprot.org/uniprot/A0A3B5R679 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Membrane http://togogenome.org/gene/8083:LOC102233783 ^@ http://purl.uniprot.org/uniprot/M3ZNI5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ATPase alpha/beta chains family.|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits. http://togogenome.org/gene/8083:arl2 ^@ http://purl.uniprot.org/uniprot/M4ARK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/8083:LOC102224503 ^@ http://purl.uniprot.org/uniprot/M4ARD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/8083:LOC102234094 ^@ http://purl.uniprot.org/uniprot/M4AGJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/8083:LOC102226142 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0Z6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102233674 ^@ http://purl.uniprot.org/uniprot/M4AC80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus|||telomere http://togogenome.org/gene/8083:LOC102231435 ^@ http://purl.uniprot.org/uniprot/M3ZCU6 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/8083:LOC102226026 ^@ http://purl.uniprot.org/uniprot/M4AJU7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/8083:gmnn ^@ http://purl.uniprot.org/uniprot/M3ZMV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the geminin family.|||Nucleus http://togogenome.org/gene/8083:LOC102235455 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q352 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:lamb3 ^@ http://purl.uniprot.org/uniprot/M4AWJ7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102224806 ^@ http://purl.uniprot.org/uniprot/M4AQI6 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/8083:dis3 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBZ5 ^@ Similarity ^@ Belongs to the RNR ribonuclease family. http://togogenome.org/gene/8083:LOC102236793 ^@ http://purl.uniprot.org/uniprot/A0A3B5QDG7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lunapark family.|||Endoplasmic reticulum membrane|||Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.|||Plays a role in determining ER morphology.|||The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation. http://togogenome.org/gene/8083:mast3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGQ2|||http://purl.uniprot.org/uniprot/M3ZWB4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/8083:ets1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QEZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/8083:nectin1 ^@ http://purl.uniprot.org/uniprot/M3ZZI5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102232639 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/8083:LOC102227817 ^@ http://purl.uniprot.org/uniprot/M3ZKT8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:tm9sf4 ^@ http://purl.uniprot.org/uniprot/M3ZPW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/8083:rnf114 ^@ http://purl.uniprot.org/uniprot/M4AM54 ^@ Subunit ^@ Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling. http://togogenome.org/gene/8083:armc8 ^@ http://purl.uniprot.org/uniprot/M3ZYN2 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/8083:dctn4 ^@ http://purl.uniprot.org/uniprot/A0A3B5R280|||http://purl.uniprot.org/uniprot/M4A6P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunit 4 family.|||cell cortex|||centrosome|||sarcomere|||stress fiber http://togogenome.org/gene/8083:dsel ^@ http://purl.uniprot.org/uniprot/M4B0Q7 ^@ Similarity ^@ Belongs to the dermatan-sulfate isomerase family. http://togogenome.org/gene/8083:nf2 ^@ http://purl.uniprot.org/uniprot/M3ZJN5 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/8083:b4galt7 ^@ http://purl.uniprot.org/uniprot/M4APX3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/8083:ppp1r10 ^@ http://purl.uniprot.org/uniprot/M4AQL3 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers. http://togogenome.org/gene/8083:hdac3 ^@ http://purl.uniprot.org/uniprot/M3ZF71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Nucleus http://togogenome.org/gene/8083:LOC102228224 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q4U0 ^@ Similarity ^@ Belongs to the TIM16/PAM16 family. http://togogenome.org/gene/8083:LOC102235384 ^@ http://purl.uniprot.org/uniprot/M4AN64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).|||Belongs to the cytochrome P450 family.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:myo16 ^@ http://purl.uniprot.org/uniprot/M4ADQ0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/8083:LOC102233844 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q459 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102233014 ^@ http://purl.uniprot.org/uniprot/M4AH14 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/8083:ezh1 ^@ http://purl.uniprot.org/uniprot/M4A3W8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102228189 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAV6 ^@ Cofactor|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit. http://togogenome.org/gene/8083:LOC102238295 ^@ http://purl.uniprot.org/uniprot/M4AY64 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/8083:LOC102237490 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1D2 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/8083:fbxo32 ^@ http://purl.uniprot.org/uniprot/M4A2J0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:mtch1 ^@ http://purl.uniprot.org/uniprot/M4AEG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:LOC102224400 ^@ http://purl.uniprot.org/uniprot/M4ALT2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/8083:exoc3l4 ^@ http://purl.uniprot.org/uniprot/M4AKF5 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/8083:gys1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QEY8 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 3 family.|||Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. http://togogenome.org/gene/8083:LOC102236904 ^@ http://purl.uniprot.org/uniprot/M3ZI46 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/8083:spc25 ^@ http://purl.uniprot.org/uniprot/M4ABM5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC25 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/8083:LOC102233151 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8V0 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:tmem65 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPB4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:nkd2 ^@ http://purl.uniprot.org/uniprot/M4AHZ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NKD family.|||Cell autonomous antagonist of the canonical Wnt signaling pathway.|||Cell membrane|||Cytoplasm http://togogenome.org/gene/8083:LOC102237909 ^@ http://purl.uniprot.org/uniprot/M3ZWY3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:ctso ^@ http://purl.uniprot.org/uniprot/A0A3B5QN48 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/8083:srd5a1 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.|||Membrane|||Microsome membrane http://togogenome.org/gene/8083:trnau1ap ^@ http://purl.uniprot.org/uniprot/M4ASF6 ^@ Similarity ^@ Belongs to the RRM TRSPAP family. http://togogenome.org/gene/8083:pdha1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1M9 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. http://togogenome.org/gene/8083:LOC102236871 ^@ http://purl.uniprot.org/uniprot/M3ZDZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the macoilin family.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/8083:LOC102226393 ^@ http://purl.uniprot.org/uniprot/M3ZRB6 ^@ Similarity ^@ Belongs to the DNA photolyase class-2 family. http://togogenome.org/gene/8083:LOC102218230 ^@ http://purl.uniprot.org/uniprot/M4A2D1 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/8083:gpbp1l1 ^@ http://purl.uniprot.org/uniprot/M4AVF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/8083:fam221a ^@ http://purl.uniprot.org/uniprot/M3ZF39 ^@ Similarity ^@ Belongs to the FAM221 family. http://togogenome.org/gene/8083:adora2a ^@ http://purl.uniprot.org/uniprot/M3ZQC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/8083:LOC102235889 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102225965 ^@ http://purl.uniprot.org/uniprot/M4AAA7 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/8083:tars2 ^@ http://purl.uniprot.org/uniprot/M4APT2 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/8083:hoxc13 ^@ http://purl.uniprot.org/uniprot/M3ZHD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/8083:sumo2 ^@ http://purl.uniprot.org/uniprot/M4AJC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/8083:pth2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parathyroid hormone family.|||Secreted http://togogenome.org/gene/8083:mxra5 ^@ http://purl.uniprot.org/uniprot/M3ZF48 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102218965 ^@ http://purl.uniprot.org/uniprot/A0A3B5QXE8 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/8083:dgkh ^@ http://purl.uniprot.org/uniprot/A0A3B5Q2Z0 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/8083:LOC102229432 ^@ http://purl.uniprot.org/uniprot/A0A3B5PTH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:med24 ^@ http://purl.uniprot.org/uniprot/M4AAC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 24 family.|||Nucleus http://togogenome.org/gene/8083:LOC102220679 ^@ http://purl.uniprot.org/uniprot/M4AGC5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/8083:LOC102238006 ^@ http://purl.uniprot.org/uniprot/M4A3L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/8083:LOC102233341 ^@ http://purl.uniprot.org/uniprot/A0A3B5QN14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/8083:LOC102236188 ^@ http://purl.uniprot.org/uniprot/A0A3B5R8Z5 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/8083:LOC102221555 ^@ http://purl.uniprot.org/uniprot/M3ZHW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:cct6a ^@ http://purl.uniprot.org/uniprot/M3ZYS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102235265 ^@ http://purl.uniprot.org/uniprot/M3ZVS6 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/8083:LOC102218840 ^@ http://purl.uniprot.org/uniprot/M4AK64 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/8083:hras ^@ http://purl.uniprot.org/uniprot/M4AL20 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/8083:grin2b ^@ http://purl.uniprot.org/uniprot/M3ZVJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/8083:sf3a3 ^@ http://purl.uniprot.org/uniprot/M4ARX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3A3 family.|||Nucleus http://togogenome.org/gene/8083:armt1 ^@ http://purl.uniprot.org/uniprot/M3ZLJ4 ^@ Domain|||Function|||Similarity ^@ Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.|||Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.|||Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine. http://togogenome.org/gene/8083:LOC102217601 ^@ http://purl.uniprot.org/uniprot/A0A3B5QNU1 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/8083:mtmr6 ^@ http://purl.uniprot.org/uniprot/M3ZES2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/8083:prdm8 ^@ http://purl.uniprot.org/uniprot/A0A3B5QL89 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102229392 ^@ http://purl.uniprot.org/uniprot/M4AJ60 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:gclc ^@ http://purl.uniprot.org/uniprot/M4A732 ^@ Similarity ^@ Belongs to the glutamate--cysteine ligase type 3 family. http://togogenome.org/gene/8083:LOC102218214 ^@ http://purl.uniprot.org/uniprot/M3ZXC2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:fam83b ^@ http://purl.uniprot.org/uniprot/M4A6Y4 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/8083:pdxp ^@ http://purl.uniprot.org/uniprot/M4AQ29 ^@ Cofactor|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||Divalent metal ions. Mg(2+) is the most effective. http://togogenome.org/gene/8083:LOC102233778 ^@ http://purl.uniprot.org/uniprot/A0A3B5R3X2 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/8083:LOC102222626 ^@ http://purl.uniprot.org/uniprot/M4AZ63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. http://togogenome.org/gene/8083:eya1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QE02|||http://purl.uniprot.org/uniprot/M4A7A5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/8083:LOC102224270 ^@ http://purl.uniprot.org/uniprot/M4B0P5 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/8083:LOC106699628 ^@ http://purl.uniprot.org/uniprot/M3ZP43 ^@ Similarity ^@ Belongs to the CD200R family. http://togogenome.org/gene/8083:hs3st4 ^@ http://purl.uniprot.org/uniprot/M4A4T6 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/8083:fev ^@ http://purl.uniprot.org/uniprot/M3ZHW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/8083:wscd2 ^@ http://purl.uniprot.org/uniprot/M4AUP8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WSCD family.|||Golgi apparatus membrane|||Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. http://togogenome.org/gene/8083:LOC102230049 ^@ http://purl.uniprot.org/uniprot/M4AT05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:flt1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QU59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102223874 ^@ http://purl.uniprot.org/uniprot/M4A802 ^@ Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Interacts with NCDN.|||Membrane http://togogenome.org/gene/8083:KEG86_p06 ^@ http://purl.uniprot.org/uniprot/B5WZ58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 3 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.|||Mitochondrion membrane http://togogenome.org/gene/8083:nme3 ^@ http://purl.uniprot.org/uniprot/M4ABW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||Cytoplasm|||Major role in the synthesis of nucleoside triphosphates other than ATP.|||Nucleus|||lamellipodium|||ruffle http://togogenome.org/gene/8083:LOC102218609 ^@ http://purl.uniprot.org/uniprot/M4B091 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:mapkapk2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZ49 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:anapc13 ^@ http://purl.uniprot.org/uniprot/A0A3B5QVW0 ^@ Function|||Similarity ^@ Belongs to the APC13 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. http://togogenome.org/gene/8083:ndrg4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAE5|||http://purl.uniprot.org/uniprot/A0A3B5QQC2|||http://purl.uniprot.org/uniprot/A0A3B5R5Y0 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/8083:KEG86_p08 ^@ http://purl.uniprot.org/uniprot/B5WZ56 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase A chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102231949 ^@ http://purl.uniprot.org/uniprot/A0A3B5PTX9 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8083:LOC106700490 ^@ http://purl.uniprot.org/uniprot/M4ALW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIII family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:slc6a11 ^@ http://purl.uniprot.org/uniprot/M4AST6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/8083:LOC102231969 ^@ http://purl.uniprot.org/uniprot/M4A053 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/8083:LOC102220772 ^@ http://purl.uniprot.org/uniprot/A0A3B5QB33 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:mef2c ^@ http://purl.uniprot.org/uniprot/A0A3B5QCA4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:slc1a2 ^@ http://purl.uniprot.org/uniprot/M3ZEZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/8083:ube2l3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QR27 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:mtap ^@ http://purl.uniprot.org/uniprot/M3ZTB6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Cytoplasm|||Homotrimer.|||Nucleus http://togogenome.org/gene/8083:zdhhc3 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q098 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/8083:LOC102237082 ^@ http://purl.uniprot.org/uniprot/M4A7N3 ^@ Similarity ^@ Belongs to the VPS10-related sortilin family. SORCS subfamily. http://togogenome.org/gene/8083:LOC102230452 ^@ http://purl.uniprot.org/uniprot/M4AFP5 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/8083:LOC102225385 ^@ http://purl.uniprot.org/uniprot/A0A3B5QXJ7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/8083:psmb4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Non-catalytic component of the proteasome.|||Nucleus http://togogenome.org/gene/8083:nsa2 ^@ http://purl.uniprot.org/uniprot/M3ZEW7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.|||nucleolus http://togogenome.org/gene/8083:LOC102238267 ^@ http://purl.uniprot.org/uniprot/M4A3K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/8083:fzd4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QT40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Membrane http://togogenome.org/gene/8083:LOC102234547 ^@ http://purl.uniprot.org/uniprot/M3ZNU8 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/8083:LOC102226395 ^@ http://purl.uniprot.org/uniprot/M4B119 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/8083:snx2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PY54 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/8083:tbca ^@ http://purl.uniprot.org/uniprot/A0A3B5QDQ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCA family.|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.|||Tubulin-folding protein; involved in the early step of the tubulin folding pathway.|||cytoskeleton http://togogenome.org/gene/8083:mul1 ^@ http://purl.uniprot.org/uniprot/M4AD98 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:usp14 ^@ http://purl.uniprot.org/uniprot/A0A3B5QND8 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C19 family. USP14/UBP6 subfamily.|||Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS. http://togogenome.org/gene/8083:LOC102227494 ^@ http://purl.uniprot.org/uniprot/A0A3B5QFD2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Nematocyst|||Target cell membrane http://togogenome.org/gene/8083:LOC102217702 ^@ http://purl.uniprot.org/uniprot/M3ZG12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102224438 ^@ http://purl.uniprot.org/uniprot/M4AD75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/8083:tnfsf11 ^@ http://purl.uniprot.org/uniprot/M3ZDN5 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/8083:nfe2 ^@ http://purl.uniprot.org/uniprot/M4A0V2 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/8083:eif5 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7N9 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/8083:LOC102227224 ^@ http://purl.uniprot.org/uniprot/M3ZG26 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/8083:gatb ^@ http://purl.uniprot.org/uniprot/M4A0V4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/8083:phax ^@ http://purl.uniprot.org/uniprot/M4B0K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PHAX family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102232037 ^@ http://purl.uniprot.org/uniprot/M3ZVB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/8083:eif2s1 ^@ http://purl.uniprot.org/uniprot/M4AS76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2-alpha family.|||Stress granule http://togogenome.org/gene/8083:tasp1 ^@ http://purl.uniprot.org/uniprot/M3ZVP3 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/8083:opn3 ^@ http://purl.uniprot.org/uniprot/M3ZZT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/8083:LOC102237985 ^@ http://purl.uniprot.org/uniprot/A0A3B5RF44 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/8083:rpl15 ^@ http://purl.uniprot.org/uniprot/M4ARS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL15 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm http://togogenome.org/gene/8083:tube1 ^@ http://purl.uniprot.org/uniprot/M3ZSK5 ^@ Similarity ^@ Belongs to the tubulin family. http://togogenome.org/gene/8083:clcn1 ^@ http://purl.uniprot.org/uniprot/M4AAW0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102223033 ^@ http://purl.uniprot.org/uniprot/A0A3B5PWQ6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8083:LOC102232209 ^@ http://purl.uniprot.org/uniprot/A0A3B5PYL1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102227711 ^@ http://purl.uniprot.org/uniprot/M4AYG8 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/8083:LOC102227593 ^@ http://purl.uniprot.org/uniprot/M3ZQ45 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/8083:yif1a ^@ http://purl.uniprot.org/uniprot/M4AFD5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Membrane http://togogenome.org/gene/8083:med27 ^@ http://purl.uniprot.org/uniprot/M3ZMZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 27 family.|||Nucleus http://togogenome.org/gene/8083:kars ^@ http://purl.uniprot.org/uniprot/A0A3B5QD89|||http://purl.uniprot.org/uniprot/M3ZLX5 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/8083:LOC102229431 ^@ http://purl.uniprot.org/uniprot/M3ZN41 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/8083:fez2 ^@ http://purl.uniprot.org/uniprot/A0A3B5RD22|||http://purl.uniprot.org/uniprot/M3ZRD2 ^@ Similarity ^@ Belongs to the zygin family. http://togogenome.org/gene/8083:smarcad1 ^@ http://purl.uniprot.org/uniprot/M4ALQ8 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/8083:ints9 ^@ http://purl.uniprot.org/uniprot/M4A8F4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.|||Nucleus http://togogenome.org/gene/8083:LOC102231214 ^@ http://purl.uniprot.org/uniprot/M4A9A3 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/8083:LOC102217951 ^@ http://purl.uniprot.org/uniprot/A0A3B5PU73 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Homodimer. Heterodimer; with a rar molecule.|||Nucleus|||Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. http://togogenome.org/gene/8083:nme7 ^@ http://purl.uniprot.org/uniprot/M4APN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||Major role in the synthesis of nucleoside triphosphates other than ATP.|||Nucleus|||cilium axoneme|||lamellipodium|||ruffle http://togogenome.org/gene/8083:zdhhc7 ^@ http://purl.uniprot.org/uniprot/M4AST1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/8083:mrps16 ^@ http://purl.uniprot.org/uniprot/M3ZCW0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/8083:LOC102237888 ^@ http://purl.uniprot.org/uniprot/M4AVP2 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/8083:LOC102216371 ^@ http://purl.uniprot.org/uniprot/A0A3B5R8G8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/8083:dr1 ^@ http://purl.uniprot.org/uniprot/M3ZLL6 ^@ Similarity ^@ Belongs to the NC2 beta/DR1 family. http://togogenome.org/gene/8083:plod2 ^@ http://purl.uniprot.org/uniprot/M4A3X9 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/8083:LOC102233799 ^@ http://purl.uniprot.org/uniprot/M3ZKR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/8083:nhp2 ^@ http://purl.uniprot.org/uniprot/M3ZXV2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/8083:LOC102221223 ^@ http://purl.uniprot.org/uniprot/M3ZLL9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102219488 ^@ http://purl.uniprot.org/uniprot/M4AU05 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/8083:LOC102219252 ^@ http://purl.uniprot.org/uniprot/M4B0S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:hoxd4 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1A8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/8083:ccnd1 ^@ http://purl.uniprot.org/uniprot/M3ZGZ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. http://togogenome.org/gene/8083:LOC102216962 ^@ http://purl.uniprot.org/uniprot/M3ZDA8 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/8083:amotl2 ^@ http://purl.uniprot.org/uniprot/M4AQ96 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/8083:LOC102218234 ^@ http://purl.uniprot.org/uniprot/A0A3B5R305 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:zadh2 ^@ http://purl.uniprot.org/uniprot/M4A3J4 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/8083:LOC102230382 ^@ http://purl.uniprot.org/uniprot/A0A3B5QYG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/8083:stat3 ^@ http://purl.uniprot.org/uniprot/M4A3I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102228058 ^@ http://purl.uniprot.org/uniprot/M4AZM5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:rpl12 ^@ http://purl.uniprot.org/uniprot/A0A3B5QLX0 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL11 family.|||Binds directly to 26S ribosomal RNA. http://togogenome.org/gene/8083:ints10 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 10 family.|||Nucleus http://togogenome.org/gene/8083:LOC102223286 ^@ http://purl.uniprot.org/uniprot/M4ANE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/8083:slco5a1 ^@ http://purl.uniprot.org/uniprot/M4A720 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102224065 ^@ http://purl.uniprot.org/uniprot/M4A3M6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Exhibits natriuretic and vasodepressant activity. Has cGMP-stimulating activity. May help to regulate body fluid homeostasis in a variety of aquatic environments.|||Secreted http://togogenome.org/gene/8083:LOC102225467 ^@ http://purl.uniprot.org/uniprot/M3ZTH8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:hdc ^@ http://purl.uniprot.org/uniprot/A0A3B5RDJ3 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/8083:cep63 ^@ http://purl.uniprot.org/uniprot/M4AQB6 ^@ Similarity ^@ Belongs to the CEP63 family. http://togogenome.org/gene/8083:ddx51 ^@ http://purl.uniprot.org/uniprot/M4A6E1 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/8083:LOC102234812 ^@ http://purl.uniprot.org/uniprot/M4AUN2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sesquipedalian family.|||Early endosome|||Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.|||Recycling endosome|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/8083:LOC102231684 ^@ http://purl.uniprot.org/uniprot/M4AS41 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/8083:LOC102230567 ^@ http://purl.uniprot.org/uniprot/M3ZQC0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102231610 ^@ http://purl.uniprot.org/uniprot/M3ZP56 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/8083:pou1f1 ^@ http://purl.uniprot.org/uniprot/M4A2U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/8083:LOC102232175 ^@ http://purl.uniprot.org/uniprot/M4AQL6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102227947 ^@ http://purl.uniprot.org/uniprot/M4ACX1 ^@ Cofactor|||Similarity ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/8083:diexf ^@ http://purl.uniprot.org/uniprot/M4A485 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP25 family.|||nucleolus http://togogenome.org/gene/8083:hmga1 ^@ http://purl.uniprot.org/uniprot/M4AQ55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGA family.|||Nucleus http://togogenome.org/gene/8083:mrps24 ^@ http://purl.uniprot.org/uniprot/M4AX14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Mitochondrion http://togogenome.org/gene/8083:gsr ^@ http://purl.uniprot.org/uniprot/M4AP93 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Cytoplasm|||Maintains high levels of reduced glutathione in the cytosol. http://togogenome.org/gene/8083:ccng1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q2Q1 ^@ Function|||Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition. http://togogenome.org/gene/8083:pipox ^@ http://purl.uniprot.org/uniprot/M4AC66 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/8083:LOC106699738 ^@ http://purl.uniprot.org/uniprot/M4APE8 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/8083:LOC102234589 ^@ http://purl.uniprot.org/uniprot/M4AFE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8083:LOC102235509 ^@ http://purl.uniprot.org/uniprot/M3ZWN2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:carm1 ^@ http://purl.uniprot.org/uniprot/M3ZK15 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102218053 ^@ http://purl.uniprot.org/uniprot/A0A3B5R1V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/8083:LOC102217829 ^@ http://purl.uniprot.org/uniprot/A0A3B5R3J4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.|||Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.|||Membrane|||This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. http://togogenome.org/gene/8083:cdk2 ^@ http://purl.uniprot.org/uniprot/M3ZM97 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:LOC102218318 ^@ http://purl.uniprot.org/uniprot/M4AEF0 ^@ Cofactor|||Similarity ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/8083:LOC102220704 ^@ http://purl.uniprot.org/uniprot/M4A5T0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102220725 ^@ http://purl.uniprot.org/uniprot/A0A3B5PQX7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:serpini1 ^@ http://purl.uniprot.org/uniprot/M4AS07 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8083:LOC102225046 ^@ http://purl.uniprot.org/uniprot/M4A8Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/8083:LOC102236844 ^@ http://purl.uniprot.org/uniprot/M3ZKL4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNF5 family.|||Component of the multiprotein chromatin-remodeling complexes SWI/SNF.|||Nucleus http://togogenome.org/gene/8083:tmem9 ^@ http://purl.uniprot.org/uniprot/M4A9D7 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/8083:lpgat1 ^@ http://purl.uniprot.org/uniprot/M4ASZ4 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/8083:slc16a13 ^@ http://purl.uniprot.org/uniprot/M4AME3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:naa38 ^@ http://purl.uniprot.org/uniprot/A0A3B5QR74 ^@ Function|||Similarity|||Subunit ^@ Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.|||Belongs to the snRNP Sm proteins family.|||Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30. http://togogenome.org/gene/8083:vps45 ^@ http://purl.uniprot.org/uniprot/M4ASJ9 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/8083:rnaseh2a ^@ http://purl.uniprot.org/uniprot/M3ZXN2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RNase HII family. Eukaryotic subfamily.|||Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/8083:osbpl9 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q908 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/8083:chaf1a ^@ http://purl.uniprot.org/uniprot/M4ABP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CHAF1A family.|||Nucleus http://togogenome.org/gene/8083:LOC102221756 ^@ http://purl.uniprot.org/uniprot/A0A3B5QCZ5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:tp53i11 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0S8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102222123 ^@ http://purl.uniprot.org/uniprot/A0A3B5PRD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/8083:inppl1 ^@ http://purl.uniprot.org/uniprot/M4A9K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.|||Membrane|||Nucleus speckle|||filopodium|||lamellipodium http://togogenome.org/gene/8083:ing4 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8K0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/8083:tekt2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QJU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||flagellum http://togogenome.org/gene/8083:steap4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QTY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/8083:slc25a1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:nelfe ^@ http://purl.uniprot.org/uniprot/M4AI08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM NELF-E family.|||Chromosome|||Nucleus http://togogenome.org/gene/8083:lhpp ^@ http://purl.uniprot.org/uniprot/M4AQ36 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/8083:LOC102235892 ^@ http://purl.uniprot.org/uniprot/A0A3B5PXZ5 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/8083:rab27a ^@ http://purl.uniprot.org/uniprot/A0A3B5RA98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/8083:LOC102224087 ^@ http://purl.uniprot.org/uniprot/A0A3B5QTU8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:LOC102224522 ^@ http://purl.uniprot.org/uniprot/M4A7H0 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of AMPK and MAPK1/2 signaling pathways.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/8083:cpb1 ^@ http://purl.uniprot.org/uniprot/M4A410 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/8083:mfsd6 ^@ http://purl.uniprot.org/uniprot/M4A7I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. MFSD6 family.|||Membrane http://togogenome.org/gene/8083:hdac5 ^@ http://purl.uniprot.org/uniprot/A0A3B5RCG1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. http://togogenome.org/gene/8083:dhcr7 ^@ http://purl.uniprot.org/uniprot/A0A3B5PYT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/8083:c6h7orf25 ^@ http://purl.uniprot.org/uniprot/M4B115 ^@ Similarity ^@ Belongs to the UPF0415 family. http://togogenome.org/gene/8083:LOC102220923 ^@ http://purl.uniprot.org/uniprot/M4A9V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/8083:treh ^@ http://purl.uniprot.org/uniprot/M3ZZJ3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 37 family. http://togogenome.org/gene/8083:LOC102222439 ^@ http://purl.uniprot.org/uniprot/M4A0B7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:dcps ^@ http://purl.uniprot.org/uniprot/A0A3B5PUS5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HIT family.|||Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.|||Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.|||Nucleus http://togogenome.org/gene/8083:LOC102230342 ^@ http://purl.uniprot.org/uniprot/M4B0W8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:LOC102235994 ^@ http://purl.uniprot.org/uniprot/M4A068 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/8083:LOC102236194 ^@ http://purl.uniprot.org/uniprot/M3ZPL0 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/8083:nedd9 ^@ http://purl.uniprot.org/uniprot/M4ANW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/8083:LOC102225350 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q984 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.|||Nucleus http://togogenome.org/gene/8083:LOC102224817 ^@ http://purl.uniprot.org/uniprot/M4ABZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:pdcd5 ^@ http://purl.uniprot.org/uniprot/M3ZLB6 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/8083:LOC102221824 ^@ http://purl.uniprot.org/uniprot/M4ARY8 ^@ Similarity ^@ Belongs to the glutaminase family. http://togogenome.org/gene/8083:LOC102224234 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q5H0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:strn3 ^@ http://purl.uniprot.org/uniprot/M4A4G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat striatin family.|||Membrane http://togogenome.org/gene/8083:cpsf4 ^@ http://purl.uniprot.org/uniprot/A0A3B5R4T8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CPSF4/YTH1 family.|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex.|||Nucleus http://togogenome.org/gene/8083:impdh2 ^@ http://purl.uniprot.org/uniprot/M4AY55 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.|||Nucleus http://togogenome.org/gene/8083:impact ^@ http://purl.uniprot.org/uniprot/M4A993 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IMPACT family.|||Cytoplasm http://togogenome.org/gene/8083:gadd45g ^@ http://purl.uniprot.org/uniprot/M4ANE1 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/8083:LOC102234151 ^@ http://purl.uniprot.org/uniprot/M3ZT11 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/8083:stt3a ^@ http://purl.uniprot.org/uniprot/M4AHI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/8083:washc1 ^@ http://purl.uniprot.org/uniprot/M3ZNY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WASH1 family.|||Early endosome membrane|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/8083:gpha2 ^@ http://purl.uniprot.org/uniprot/M4A2N3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Heterodimer of an alpha and a beta chain.|||Secreted http://togogenome.org/gene/8083:LOC102226237 ^@ http://purl.uniprot.org/uniprot/M3ZR10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the band 7/mec-2 family.|||Membrane http://togogenome.org/gene/8083:LOC102216602 ^@ http://purl.uniprot.org/uniprot/M3ZH00 ^@ Cofactor|||Similarity ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/8083:ddrgk1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QIR0 ^@ Similarity ^@ Belongs to the DDRGK1 family. http://togogenome.org/gene/8083:hmmr ^@ http://purl.uniprot.org/uniprot/M4A7U9 ^@ Subcellular Location Annotation ^@ spindle http://togogenome.org/gene/8083:gapdh ^@ http://purl.uniprot.org/uniprot/M4AAH8 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/8083:gucy1a1 ^@ http://purl.uniprot.org/uniprot/M3ZTY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/8083:etnppl ^@ http://purl.uniprot.org/uniprot/A0A3B5Q740 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/8083:LOC102230038 ^@ http://purl.uniprot.org/uniprot/M4A537 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/8083:LOC102220631 ^@ http://purl.uniprot.org/uniprot/M3ZXG1 ^@ Similarity ^@ Belongs to the MAP65/ASE1 family. http://togogenome.org/gene/8083:acy1 ^@ http://purl.uniprot.org/uniprot/M4AS52 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Binds 2 Zn(2+) ions per subunit.|||Cytoplasm http://togogenome.org/gene/8083:echdc1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QDP0 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/8083:scap ^@ http://purl.uniprot.org/uniprot/A0A3B5R5E2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SCAP family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/8083:cant1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QW38|||http://purl.uniprot.org/uniprot/M4AD49 ^@ Similarity ^@ Belongs to the apyrase family. http://togogenome.org/gene/8083:fuca2 ^@ http://purl.uniprot.org/uniprot/A0A3B5R1H0 ^@ Function|||Similarity|||Subunit ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family.|||Homotetramer. http://togogenome.org/gene/8083:LOC102232328 ^@ http://purl.uniprot.org/uniprot/M3ZN18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELAPOR family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:snapc3 ^@ http://purl.uniprot.org/uniprot/M4A6Q7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAPC3/SRD2 family.|||Nucleus|||Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.|||Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. http://togogenome.org/gene/8083:LOC102219178 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q906 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/8083:LOC102229074 ^@ http://purl.uniprot.org/uniprot/M3ZLL8 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/8083:LOC102233485 ^@ http://purl.uniprot.org/uniprot/M3ZM94 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102227112 ^@ http://purl.uniprot.org/uniprot/M3ZT86 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/8083:fam214b ^@ http://purl.uniprot.org/uniprot/A0A3B5PW97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATOS family.|||Nucleus http://togogenome.org/gene/8083:nop16 ^@ http://purl.uniprot.org/uniprot/A0A3B5QT82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP16 family.|||nucleolus http://togogenome.org/gene/8083:LOC102233259 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQQ0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Homodimer.|||Secreted http://togogenome.org/gene/8083:haao ^@ http://purl.uniprot.org/uniprot/A0A3B5PRK0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 3-HAO family.|||Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/8083:LOC102217427 ^@ http://purl.uniprot.org/uniprot/M4AWB7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC106699945 ^@ http://purl.uniprot.org/uniprot/M3ZE68 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:med14 ^@ http://purl.uniprot.org/uniprot/M4AUB1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 14 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/8083:exoc4 ^@ http://purl.uniprot.org/uniprot/A0A3B5PZH2 ^@ Function|||Similarity ^@ Belongs to the SEC8 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/8083:atoh7 ^@ http://purl.uniprot.org/uniprot/M4AZI1 ^@ Subcellular Location Annotation ^@ Nucleus|||Perikaryon|||axon http://togogenome.org/gene/8083:tmem14a ^@ http://purl.uniprot.org/uniprot/A0A3B5RF17 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/8083:zdhhc22 ^@ http://purl.uniprot.org/uniprot/M4ALB1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/8083:rpl18 ^@ http://purl.uniprot.org/uniprot/A0A3B5RC78 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL18 family. http://togogenome.org/gene/8083:LOC102220834 ^@ http://purl.uniprot.org/uniprot/M3ZF03 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/8083:LOC102226978 ^@ http://purl.uniprot.org/uniprot/M4ARG7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:nox4 ^@ http://purl.uniprot.org/uniprot/M4A9T6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102231316 ^@ http://purl.uniprot.org/uniprot/M3ZLV3 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/8083:LOC102235300 ^@ http://purl.uniprot.org/uniprot/M4AGR3 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/8083:bdh1 ^@ http://purl.uniprot.org/uniprot/M4A427 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:LOC102236424 ^@ http://purl.uniprot.org/uniprot/M4AC79 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:mtmr2 ^@ http://purl.uniprot.org/uniprot/M4AAJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/8083:onecut1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PZ88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/8083:LOC102216903 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q6T7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFC2 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102216983 ^@ http://purl.uniprot.org/uniprot/A0A3B5R0S0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:tmtc4 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/8083:LOC102218975 ^@ http://purl.uniprot.org/uniprot/M4AE63 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:ttyh3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPK5|||http://purl.uniprot.org/uniprot/A0A3B5R489 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tweety family.|||Cell membrane|||Membrane|||Probable chloride channel. http://togogenome.org/gene/8083:cenpj ^@ http://purl.uniprot.org/uniprot/M4AJZ3 ^@ Similarity ^@ Belongs to the TCP10 family. http://togogenome.org/gene/8083:LOC102230282 ^@ http://purl.uniprot.org/uniprot/A0A3B5R6V7 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/8083:LOC102228484 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3R3 ^@ Function|||Similarity|||Subunit ^@ Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.|||Homotetramer.|||In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.|||In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. http://togogenome.org/gene/8083:dmrt2 ^@ http://purl.uniprot.org/uniprot/Q8QGP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/8083:LOC102236256 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAL9 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/8083:cisd2 ^@ http://purl.uniprot.org/uniprot/M3ZUT2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CISD protein family. CISD2 subfamily.|||Binds 1 [2Fe-2S] cluster.|||Endoplasmic reticulum membrane|||Homodimer.|||Mitochondrion outer membrane|||Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. http://togogenome.org/gene/8083:smpd2 ^@ http://purl.uniprot.org/uniprot/M4AUI3 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/8083:cdk14 ^@ http://purl.uniprot.org/uniprot/A0A3B5QUQ6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:fgf13 ^@ http://purl.uniprot.org/uniprot/A0A3B5PV14 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:LOC102219277 ^@ http://purl.uniprot.org/uniprot/A0A3B5QKD9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:ess2 ^@ http://purl.uniprot.org/uniprot/M4AI94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESS2 family.|||Nucleus http://togogenome.org/gene/8083:LOC102223464 ^@ http://purl.uniprot.org/uniprot/M4AEX6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:dtd2 ^@ http://purl.uniprot.org/uniprot/M4AXG8 ^@ Similarity ^@ Belongs to the DTD family. http://togogenome.org/gene/8083:ift20 ^@ http://purl.uniprot.org/uniprot/M3ZUI2 ^@ Subcellular Location Annotation ^@ centriole|||cilium|||cis-Golgi network http://togogenome.org/gene/8083:LOC102228827 ^@ http://purl.uniprot.org/uniprot/M4A2C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/8083:rrad ^@ http://purl.uniprot.org/uniprot/M4AXA4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/8083:LOC102229255 ^@ http://purl.uniprot.org/uniprot/M4ASP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102238213 ^@ http://purl.uniprot.org/uniprot/M3ZDU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/8083:apip ^@ http://purl.uniprot.org/uniprot/M3ZGZ5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aldolase class II family. Adducin subfamily.|||Belongs to the aldolase class II family. MtnB subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis.|||Cytoplasm http://togogenome.org/gene/8083:LOC102232752 ^@ http://purl.uniprot.org/uniprot/A0A3B5R0F9 ^@ Similarity ^@ Belongs to the ADISSP family. http://togogenome.org/gene/8083:gpc2 ^@ http://purl.uniprot.org/uniprot/M4APS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/8083:tusc5 ^@ http://purl.uniprot.org/uniprot/M4A210 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/8083:dazap2 ^@ http://purl.uniprot.org/uniprot/M3ZSK6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus speckle|||nuclear body http://togogenome.org/gene/8083:psmb3 ^@ http://purl.uniprot.org/uniprot/M4AUK8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:ins ^@ http://purl.uniprot.org/uniprot/A0A3B5QHU8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Heterodimer of a B chain and an A chain linked by two disulfide bonds.|||Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.|||Secreted http://togogenome.org/gene/8083:LOC102218775 ^@ http://purl.uniprot.org/uniprot/M4A885 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin.|||Cytoplasm|||Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.|||lamellipodium http://togogenome.org/gene/8083:opa3 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q546 ^@ Function|||Similarity ^@ Belongs to the OPA3 family.|||May play some role in mitochondrial processes. http://togogenome.org/gene/8083:LOC102236488 ^@ http://purl.uniprot.org/uniprot/M3ZIH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 18 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:sbno2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QG64 ^@ Similarity ^@ Belongs to the SBNO family. http://togogenome.org/gene/8083:dpf1 ^@ http://purl.uniprot.org/uniprot/M3ZKK0 ^@ Similarity ^@ Belongs to the requiem/DPF family. http://togogenome.org/gene/8083:dkc1 ^@ http://purl.uniprot.org/uniprot/M3ZRU7 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/8083:polr3d ^@ http://purl.uniprot.org/uniprot/M3ZI27 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:hpn ^@ http://purl.uniprot.org/uniprot/M4A361 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular space http://togogenome.org/gene/8083:wapl ^@ http://purl.uniprot.org/uniprot/M4AVA1 ^@ Similarity ^@ Belongs to the WAPL family. http://togogenome.org/gene/8083:bmp7 ^@ http://purl.uniprot.org/uniprot/M4ATT5 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/8083:hapln3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QE42 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102234150 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:prune1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PWI0 ^@ Similarity ^@ Belongs to the PPase class C family. Prune subfamily. http://togogenome.org/gene/8083:LOC102218594 ^@ http://purl.uniprot.org/uniprot/M4A1U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HEXIM family.|||Nucleus http://togogenome.org/gene/8083:rpe65 ^@ http://purl.uniprot.org/uniprot/A0A3B5QS32 ^@ Cofactor|||Similarity ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/8083:KEG86_p09 ^@ http://purl.uniprot.org/uniprot/B5WZ55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase protein 8 family.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/8083:LOC102235526 ^@ http://purl.uniprot.org/uniprot/M4A9H7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/8083:LOC102220588 ^@ http://purl.uniprot.org/uniprot/M4ARW1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/8083:LOC106699967 ^@ http://purl.uniprot.org/uniprot/A0A3B5PTX1 ^@ Similarity ^@ Belongs to the HARBI1 family. http://togogenome.org/gene/8083:LOC102229228 ^@ http://purl.uniprot.org/uniprot/A0A3B5QIH2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:tmem167b ^@ http://purl.uniprot.org/uniprot/M4AX28 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:foxi2 ^@ http://purl.uniprot.org/uniprot/M4APG8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102237956 ^@ http://purl.uniprot.org/uniprot/M4AAP2 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:dda1 ^@ http://purl.uniprot.org/uniprot/M3ZJL3 ^@ Similarity ^@ Belongs to the DDA1 family. http://togogenome.org/gene/8083:LOC102235469 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHV5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:pde6g ^@ http://purl.uniprot.org/uniprot/M4AQH9 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/8083:usp16 ^@ http://purl.uniprot.org/uniprot/M3ZYP3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C19 family. USP16 subfamily.|||Homotetramer.|||Nucleus|||Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.|||The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin. http://togogenome.org/gene/8083:LOC102221818 ^@ http://purl.uniprot.org/uniprot/M3ZNJ4 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/8083:LOC102237095 ^@ http://purl.uniprot.org/uniprot/M3ZJE1 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/8083:serpinc1 ^@ http://purl.uniprot.org/uniprot/M3ZTP7 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8083:pdcd4 ^@ http://purl.uniprot.org/uniprot/M3ZXN0 ^@ Similarity ^@ Belongs to the PDCD4 family. http://togogenome.org/gene/8083:tpt1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QMX6 ^@ Similarity ^@ Belongs to the TCTP family. http://togogenome.org/gene/8083:pex16 ^@ http://purl.uniprot.org/uniprot/M4AI17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-16 family.|||Peroxisome membrane http://togogenome.org/gene/8083:slc7a6 ^@ http://purl.uniprot.org/uniprot/A0A3B5R0J5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102230979 ^@ http://purl.uniprot.org/uniprot/M3ZHK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STOP family.|||cytoskeleton http://togogenome.org/gene/8083:dhodh ^@ http://purl.uniprot.org/uniprot/M4AV79 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:glyr1 ^@ http://purl.uniprot.org/uniprot/M4AKR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HIBADH-related family. NP60 subfamily.|||Chromosome http://togogenome.org/gene/8083:clpp ^@ http://purl.uniprot.org/uniprot/M3ZJZ7 ^@ Similarity ^@ Belongs to the peptidase S14 family. http://togogenome.org/gene/8083:mrpl37 ^@ http://purl.uniprot.org/uniprot/M4AWM0 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/8083:prdx5 ^@ http://purl.uniprot.org/uniprot/M3ZSC5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxiredoxin family. Prx5 subfamily.|||Peroxisome matrix|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. http://togogenome.org/gene/8083:gabra4 ^@ http://purl.uniprot.org/uniprot/M3ZPL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:LOC102224598 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQ15 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/8083:c10h17orf62 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYBC1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102236634 ^@ http://purl.uniprot.org/uniprot/M3ZYV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:LOC102234402 ^@ http://purl.uniprot.org/uniprot/M4AN42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||clathrin-coated pit http://togogenome.org/gene/8083:LOC102238122 ^@ http://purl.uniprot.org/uniprot/A0A3B5RCY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:taf10 ^@ http://purl.uniprot.org/uniprot/M4AWA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF10 family.|||Nucleus http://togogenome.org/gene/8083:LOC102220056 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q388 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102235062 ^@ http://purl.uniprot.org/uniprot/M3ZDX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/8083:LOC102229027 ^@ http://purl.uniprot.org/uniprot/A0A3B5R769 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CARMIL family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102227217 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZ05 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/8083:kcng3 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7U7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:orc3 ^@ http://purl.uniprot.org/uniprot/M4A098 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC3 family.|||Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.|||Nucleus http://togogenome.org/gene/8083:pik3cd ^@ http://purl.uniprot.org/uniprot/A0A3B5QGP0 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/8083:ddit3 ^@ http://purl.uniprot.org/uniprot/M4AU10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family.|||Cytoplasm http://togogenome.org/gene/8083:gucy1b1 ^@ http://purl.uniprot.org/uniprot/M3ZU00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102223324 ^@ http://purl.uniprot.org/uniprot/A0A3B5R913 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of AMPK and MAPK1/2 signaling pathways.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/8083:LOC102225624 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZ17 ^@ Similarity ^@ Belongs to the EAF family. http://togogenome.org/gene/8083:LOC102228257 ^@ http://purl.uniprot.org/uniprot/M4A9H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Nucleus http://togogenome.org/gene/8083:ssu72 ^@ http://purl.uniprot.org/uniprot/M4AQ82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSU72 phosphatase family.|||Nucleus|||Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. http://togogenome.org/gene/8083:rbm47 ^@ http://purl.uniprot.org/uniprot/M4A601 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM RBM47 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:ppp2r5a ^@ http://purl.uniprot.org/uniprot/M4ASS6 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family. http://togogenome.org/gene/8083:arpc4 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1S9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARPC4 family.|||Cell projection|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.|||cytoskeleton http://togogenome.org/gene/8083:LOC102227357 ^@ http://purl.uniprot.org/uniprot/M3ZWD1 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/8083:sgsm3 ^@ http://purl.uniprot.org/uniprot/M4AHZ9 ^@ Similarity ^@ Belongs to the small G protein signaling modulator family. http://togogenome.org/gene/8083:pih1d1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QEW0 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/8083:LOC102228160 ^@ http://purl.uniprot.org/uniprot/A0A3B5PRK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/8083:ighmbp2 ^@ http://purl.uniprot.org/uniprot/M3ZNC7 ^@ Similarity ^@ Belongs to the DNA2/NAM7 helicase family. http://togogenome.org/gene/8083:LOC102231753 ^@ http://purl.uniprot.org/uniprot/M3ZXB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/8083:gria2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PY58|||http://purl.uniprot.org/uniprot/M3ZJ35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/8083:LOC102236373 ^@ http://purl.uniprot.org/uniprot/M4B0V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/8083:atp5pb ^@ http://purl.uniprot.org/uniprot/A0A3B5PUQ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ATPase B chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/8083:cdh20 ^@ http://purl.uniprot.org/uniprot/A0A3B5QNE8 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/8083:rps11 ^@ http://purl.uniprot.org/uniprot/M4A471 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/8083:zisupton ^@ http://purl.uniprot.org/uniprot/G3KL21 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/8083:saraf ^@ http://purl.uniprot.org/uniprot/M4ANE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SARAF family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102234294 ^@ http://purl.uniprot.org/uniprot/M4AIM7 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/8083:LOC102218783 ^@ http://purl.uniprot.org/uniprot/M3ZZU1 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/8083:LOC102235537 ^@ http://purl.uniprot.org/uniprot/M4ALU9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/8083:LOC102216783 ^@ http://purl.uniprot.org/uniprot/M4AIG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/8083:LOC102223480 ^@ http://purl.uniprot.org/uniprot/A0A3B5R801|||http://purl.uniprot.org/uniprot/M4AAL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/8083:LOC102223777 ^@ http://purl.uniprot.org/uniprot/M4A4L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102220559 ^@ http://purl.uniprot.org/uniprot/M4ABA1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:kdelr3 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q4K0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102221334 ^@ http://purl.uniprot.org/uniprot/A0A3B5QW97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSG1 family.|||Membrane http://togogenome.org/gene/8083:LOC102220143 ^@ http://purl.uniprot.org/uniprot/M4AXZ5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102221048 ^@ http://purl.uniprot.org/uniprot/M4AYN0 ^@ Similarity ^@ Belongs to the bZIP family. NFIL3 subfamily. http://togogenome.org/gene/8083:ucn ^@ http://purl.uniprot.org/uniprot/M4B032 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/8083:rsad2 ^@ http://purl.uniprot.org/uniprot/M4A0P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RSAD2 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:ski ^@ http://purl.uniprot.org/uniprot/A0A3B5Q250 ^@ Similarity ^@ Belongs to the SKI family. http://togogenome.org/gene/8083:LOC102223041 ^@ http://purl.uniprot.org/uniprot/M3ZNF3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102232293 ^@ http://purl.uniprot.org/uniprot/M4ANU3 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/8083:nkx6-2 ^@ http://purl.uniprot.org/uniprot/M3ZZD3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:ndufa10 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1M4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA10 subunit family.|||Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.|||Mitochondrion matrix http://togogenome.org/gene/8083:oprk1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QNH7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.|||Interacts with NHERF1. Interacts with GABARAPL1.|||Membrane http://togogenome.org/gene/8083:LOC102232180 ^@ http://purl.uniprot.org/uniprot/M4AWC7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:naf1 ^@ http://purl.uniprot.org/uniprot/M4AAM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAF1 family.|||Nucleus http://togogenome.org/gene/8083:LOC102234945 ^@ http://purl.uniprot.org/uniprot/M3ZUS1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alkaline phosphatase family.|||Binds 1 Mg(2+) ion.|||Binds 2 Zn(2+) ions.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/8083:LOC102217453 ^@ http://purl.uniprot.org/uniprot/M4AWX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:cnep1r1 ^@ http://purl.uniprot.org/uniprot/M4APW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNEP1R1 family.|||Cytoplasm|||Membrane|||Nucleus membrane http://togogenome.org/gene/8083:LOC102217758 ^@ http://purl.uniprot.org/uniprot/A0A3B5QVX9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit E family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:mzt1 ^@ http://purl.uniprot.org/uniprot/M4AUU9 ^@ Function|||Similarity ^@ Belongs to the MOZART1 family.|||Required for gamma-tubulin complex recruitment to the centrosome. http://togogenome.org/gene/8083:LOC102227515 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQY9 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/8083:LOC102230074 ^@ http://purl.uniprot.org/uniprot/M4ASG7 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/8083:paqr6 ^@ http://purl.uniprot.org/uniprot/M4AGD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/8083:LOC102226786 ^@ http://purl.uniprot.org/uniprot/M3ZDE7 ^@ Similarity ^@ Belongs to the apyrase family. http://togogenome.org/gene/8083:LOC102222987 ^@ http://purl.uniprot.org/uniprot/A0A3B5PZ62 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102231064 ^@ http://purl.uniprot.org/uniprot/M4ANY0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/8083:popdc2 ^@ http://purl.uniprot.org/uniprot/M4AKG9 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/8083:LOC102217508 ^@ http://purl.uniprot.org/uniprot/M4A3Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hepcidin family.|||Secreted http://togogenome.org/gene/8083:eif2b4 ^@ http://purl.uniprot.org/uniprot/M3ZPN5 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/8083:slc30a7 ^@ http://purl.uniprot.org/uniprot/A0A3B5QY72 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Functions as a zinc transporter.|||Homooligomer.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/8083:kat2a ^@ http://purl.uniprot.org/uniprot/M4A3C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. GCN5 subfamily.|||Nucleus|||centrosome http://togogenome.org/gene/8083:LOC102223294 ^@ http://purl.uniprot.org/uniprot/M3ZET9 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:nol12 ^@ http://purl.uniprot.org/uniprot/M3ZVA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP17 family.|||nucleolus http://togogenome.org/gene/8083:LOC102228860 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAJ9 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/8083:axin1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PSA6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:LOC102225713 ^@ http://purl.uniprot.org/uniprot/A0A3B5R910 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8083:ss18 ^@ http://purl.uniprot.org/uniprot/A0A3B5PZ42|||http://purl.uniprot.org/uniprot/A0A3B5R9K7|||http://purl.uniprot.org/uniprot/M4AQA2 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/8083:rrp7a ^@ http://purl.uniprot.org/uniprot/M3ZVE9 ^@ Similarity ^@ Belongs to the RRP7 family. http://togogenome.org/gene/8083:mettl1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PSU7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Forms a complex with WDR4.|||Nucleus http://togogenome.org/gene/8083:taf8 ^@ http://purl.uniprot.org/uniprot/M3ZGP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF8 family.|||Nucleus http://togogenome.org/gene/8083:LOC102238282 ^@ http://purl.uniprot.org/uniprot/M4AHY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/8083:mtf2 ^@ http://purl.uniprot.org/uniprot/M3ZPE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/8083:LOC102218600 ^@ http://purl.uniprot.org/uniprot/M4AB36 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/8083:trhr ^@ http://purl.uniprot.org/uniprot/M3ZY08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/8083:LOC102230088 ^@ http://purl.uniprot.org/uniprot/M3ZL19 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/8083:LOC106699927 ^@ http://purl.uniprot.org/uniprot/A0A3B5PP39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/8083:hddc2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QTM7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HDDC2 family.|||Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).|||Homodimer. http://togogenome.org/gene/8083:LOC102219494 ^@ http://purl.uniprot.org/uniprot/M4A932 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/8083:dph2 ^@ http://purl.uniprot.org/uniprot/M3ZIC7 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family. DPH2 subfamily.|||Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit. http://togogenome.org/gene/8083:kcng4 ^@ http://purl.uniprot.org/uniprot/M3ZT34 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:supv3l1 ^@ http://purl.uniprot.org/uniprot/M4AJD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family.|||mitochondrion nucleoid http://togogenome.org/gene/8083:LOC102231305 ^@ http://purl.uniprot.org/uniprot/M4A3Y3 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/8083:lmbr1l ^@ http://purl.uniprot.org/uniprot/A0A3B5QJ46 ^@ Similarity ^@ Belongs to the LIMR family. http://togogenome.org/gene/8083:aatf ^@ http://purl.uniprot.org/uniprot/M4B0K7 ^@ Similarity ^@ Belongs to the AATF family. http://togogenome.org/gene/8083:LOC102218182 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAA4 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/8083:LOC102222618 ^@ http://purl.uniprot.org/uniprot/M4AYQ9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/8083:alg5 ^@ http://purl.uniprot.org/uniprot/M4A2D9 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/8083:tdp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQ19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosyl-DNA phosphodiesterase family.|||Nucleus http://togogenome.org/gene/8083:anp32e ^@ http://purl.uniprot.org/uniprot/A0A3B5R4R9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/8083:LOC102226745 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q7E0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tweety family.|||Cell membrane|||Membrane|||Probable chloride channel. http://togogenome.org/gene/8083:adgrb3 ^@ http://purl.uniprot.org/uniprot/M4A4W8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:chst10 ^@ http://purl.uniprot.org/uniprot/A0A3B5QJ31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:hhip ^@ http://purl.uniprot.org/uniprot/M4A5D1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:pmvk ^@ http://purl.uniprot.org/uniprot/A0A3B5QMN6 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/8083:psmd9 ^@ http://purl.uniprot.org/uniprot/M4ASX6 ^@ Similarity ^@ Belongs to the proteasome subunit p27 family. http://togogenome.org/gene/8083:LOC102216505 ^@ http://purl.uniprot.org/uniprot/A0A3B5R0M7 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/8083:LOC102218167 ^@ http://purl.uniprot.org/uniprot/M4AP23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.|||Lateral cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synaptic cell membrane|||axon|||dendrite|||sarcolemma|||synaptosome http://togogenome.org/gene/8083:fam234a ^@ http://purl.uniprot.org/uniprot/M4AW34 ^@ Similarity ^@ Belongs to the FAM234 family. http://togogenome.org/gene/8083:lamtor1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QP98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/8083:mtfp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R6G9 ^@ Similarity ^@ Belongs to the MTFP1 family. http://togogenome.org/gene/8083:etf1 ^@ http://purl.uniprot.org/uniprot/M3ZRZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102235740 ^@ http://purl.uniprot.org/uniprot/M3ZUT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/8083:mrps18b ^@ http://purl.uniprot.org/uniprot/M4AQJ2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily. http://togogenome.org/gene/8083:lzts2 ^@ http://purl.uniprot.org/uniprot/M4AT98 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LZTS2 family.|||Cytoplasm|||Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.|||centrosome http://togogenome.org/gene/8083:LOC102216521 ^@ http://purl.uniprot.org/uniprot/A0A3B5R424 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/8083:riok2 ^@ http://purl.uniprot.org/uniprot/M3ZZ13 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/8083:rpl28 ^@ http://purl.uniprot.org/uniprot/M3ZSL0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL28 family. http://togogenome.org/gene/8083:psmb1 ^@ http://purl.uniprot.org/uniprot/M4AKJ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102220925 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q1L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF4 family.|||Nucleus http://togogenome.org/gene/8083:grb14 ^@ http://purl.uniprot.org/uniprot/M4AAY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/8083:tap1 ^@ http://purl.uniprot.org/uniprot/M4AW18 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102217450 ^@ http://purl.uniprot.org/uniprot/A0A3B5QG82 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/8083:LOC102226580 ^@ http://purl.uniprot.org/uniprot/M4AE72 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/8083:sdr16c5 ^@ http://purl.uniprot.org/uniprot/M3ZFN9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:myo3a ^@ http://purl.uniprot.org/uniprot/M4A1G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||cytoskeleton http://togogenome.org/gene/8083:LOC102225292 ^@ http://purl.uniprot.org/uniprot/M4ARM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ninjurin family.|||Membrane http://togogenome.org/gene/8083:cacybp ^@ http://purl.uniprot.org/uniprot/M4AN10 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).|||Nucleus http://togogenome.org/gene/8083:aimp2 ^@ http://purl.uniprot.org/uniprot/M4AJN5 ^@ Subcellular Location Annotation ^@ Nucleus|||cytosol http://togogenome.org/gene/8083:enpep ^@ http://purl.uniprot.org/uniprot/M4AH24 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/8083:rpa3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QM39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 3 family.|||Nucleus http://togogenome.org/gene/8083:LOC102238066 ^@ http://purl.uniprot.org/uniprot/M4AHQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/8083:LOC102221502 ^@ http://purl.uniprot.org/uniprot/M3ZJZ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/8083:LOC102228631 ^@ http://purl.uniprot.org/uniprot/M4A9K7 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/8083:plac8l1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8G5 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/8083:ube2r2 ^@ http://purl.uniprot.org/uniprot/M3ZMH5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:entpd3 ^@ http://purl.uniprot.org/uniprot/M3ZEV6 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/8083:LOC102233241 ^@ http://purl.uniprot.org/uniprot/M4A182 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/8083:LOC102226180 ^@ http://purl.uniprot.org/uniprot/M3ZK72 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/8083:rbm17 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZQ8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the spliceosome.|||Nucleus|||Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. http://togogenome.org/gene/8083:plpbp ^@ http://purl.uniprot.org/uniprot/M3ZQ71 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. http://togogenome.org/gene/8083:ost4 ^@ http://purl.uniprot.org/uniprot/M4AZR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:rab32 ^@ http://purl.uniprot.org/uniprot/M3ZL89 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/8083:mrps7 ^@ http://purl.uniprot.org/uniprot/A0A3B5R9E1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/8083:LOC102217296 ^@ http://purl.uniprot.org/uniprot/M3ZY58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/8083:LOC102221646 ^@ http://purl.uniprot.org/uniprot/M4A8F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:LOC102221501 ^@ http://purl.uniprot.org/uniprot/M4AJH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/8083:LOC102238367 ^@ http://purl.uniprot.org/uniprot/M4AB46 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:LOC102229577 ^@ http://purl.uniprot.org/uniprot/M3ZQ63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/8083:tmem208 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM208 family.|||Endoplasmic reticulum membrane|||May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.|||Membrane http://togogenome.org/gene/8083:LOC102224119 ^@ http://purl.uniprot.org/uniprot/A0A3B5QJD4 ^@ Similarity ^@ Belongs to the TMEM178 family. http://togogenome.org/gene/8083:LOC102230481 ^@ http://purl.uniprot.org/uniprot/A0A3B5QXY6 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:LOC102226672 ^@ http://purl.uniprot.org/uniprot/A0A3B5QV00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/8083:LOC102217542 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q616 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ELO family. ELOVL4 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Oligomer. http://togogenome.org/gene/8083:LOC102233360 ^@ http://purl.uniprot.org/uniprot/M3ZSV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/8083:cda ^@ http://purl.uniprot.org/uniprot/A0A3B5QYD0 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/8083:mief1 ^@ http://purl.uniprot.org/uniprot/M3ZG01 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/8083:hnf4a ^@ http://purl.uniprot.org/uniprot/A0A3B5QGK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/8083:KEG86_p10 ^@ http://purl.uniprot.org/uniprot/B5WZ54 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102225761 ^@ http://purl.uniprot.org/uniprot/M4AYM6 ^@ Function ^@ Plays a role in skin pigmentation by antagonizing the action of melanotropin alpha. Induces melanin concentration within the melanophores. May participate in the control of the hypothalamo-pituitary adrenal gland axis by inhibiting the release of ACTH. http://togogenome.org/gene/8083:haus3 ^@ http://purl.uniprot.org/uniprot/M3ZHQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS3 family.|||spindle http://togogenome.org/gene/8083:abcc10 ^@ http://purl.uniprot.org/uniprot/M4A4W2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102235380 ^@ http://purl.uniprot.org/uniprot/M4A179 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/8083:gpc5 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/8083:LOC102230375 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/8083:ccser2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PXE8 ^@ Similarity ^@ Belongs to the CCSER family. http://togogenome.org/gene/8083:LOC102220948 ^@ http://purl.uniprot.org/uniprot/A0A3B5PZI7 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/8083:lin9 ^@ http://purl.uniprot.org/uniprot/M3ZZ48 ^@ Similarity ^@ Belongs to the lin-9 family. http://togogenome.org/gene/8083:mfsd10 ^@ http://purl.uniprot.org/uniprot/M3ZLJ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:ppp4r3a ^@ http://purl.uniprot.org/uniprot/M3ZMF0 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/8083:wdr82 ^@ http://purl.uniprot.org/uniprot/M4ARA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SWD2 family.|||Nucleus http://togogenome.org/gene/8083:LOC102224668 ^@ http://purl.uniprot.org/uniprot/M4ATA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/8083:rgma ^@ http://purl.uniprot.org/uniprot/M3ZKG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:gga3 ^@ http://purl.uniprot.org/uniprot/M3ZWW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/8083:LOC102227978 ^@ http://purl.uniprot.org/uniprot/M4APM8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked.|||Its primary function is the prevention of hypercalcemia. Upon release into the circulation, it lowers calcium transport by the gills, thereby reducing its rate of influx from the environment into the extracellular compartment. STC also stimulates phosphate reabsorption by renal proximal tubules. The consequence of this action is increased levels of plasma phosphate, which combines with excess calcium and promotes its disposal into bone and scales. http://togogenome.org/gene/8083:b9d1 ^@ http://purl.uniprot.org/uniprot/M3ZDJ0 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/8083:exosc9 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUZ8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:napg ^@ http://purl.uniprot.org/uniprot/M3ZF89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane http://togogenome.org/gene/8083:mmp9 ^@ http://purl.uniprot.org/uniprot/M4A6X2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||extracellular matrix http://togogenome.org/gene/8083:emc6 ^@ http://purl.uniprot.org/uniprot/M4B014 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC6 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:bud13 ^@ http://purl.uniprot.org/uniprot/M4A8Y8 ^@ Similarity ^@ Belongs to the CWC26 family. http://togogenome.org/gene/8083:actl6a ^@ http://purl.uniprot.org/uniprot/M4AUY7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/8083:LOC102230669 ^@ http://purl.uniprot.org/uniprot/A0A3B5PW23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/8083:clrn1 ^@ http://purl.uniprot.org/uniprot/M4AHT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/8083:rps5 ^@ http://purl.uniprot.org/uniprot/M4AIE2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/8083:slco4a1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QC07 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102235517 ^@ http://purl.uniprot.org/uniprot/M4A135 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8083:ilf3 ^@ http://purl.uniprot.org/uniprot/M4A335 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102227930 ^@ http://purl.uniprot.org/uniprot/M4A7D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/8083:med28 ^@ http://purl.uniprot.org/uniprot/A0A3B5PXS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 28 family.|||Nucleus http://togogenome.org/gene/8083:dgkb ^@ http://purl.uniprot.org/uniprot/A0A3B5RE70 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/8083:snrpd2 ^@ http://purl.uniprot.org/uniprot/M3ZFL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/8083:LOC102222205 ^@ http://purl.uniprot.org/uniprot/M3ZXX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:cnih1 ^@ http://purl.uniprot.org/uniprot/M3ZZM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/8083:LOC102237140 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8M8 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:LOC102226421 ^@ http://purl.uniprot.org/uniprot/M4AIM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.|||Nucleus http://togogenome.org/gene/8083:LOC102220727 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3C1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102234551 ^@ http://purl.uniprot.org/uniprot/M4AKW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Recycling endosome|||phagosome|||trans-Golgi network membrane http://togogenome.org/gene/8083:dlgap1 ^@ http://purl.uniprot.org/uniprot/M3ZJY7 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/8083:LOC102224584 ^@ http://purl.uniprot.org/uniprot/M3ZDN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:churc1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QW59 ^@ Similarity ^@ Belongs to the Churchill family. http://togogenome.org/gene/8083:rabac1 ^@ http://purl.uniprot.org/uniprot/M4A8R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/8083:LOC102229508 ^@ http://purl.uniprot.org/uniprot/A0A3B5PTK9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Homooctamer.|||UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. http://togogenome.org/gene/8083:tmem267 ^@ http://purl.uniprot.org/uniprot/M3ZPK0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102237753 ^@ http://purl.uniprot.org/uniprot/A0A3B5R3E3 ^@ Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. http://togogenome.org/gene/8083:ppic ^@ http://purl.uniprot.org/uniprot/A0A3B5QNZ6 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/8083:LOC102217424 ^@ http://purl.uniprot.org/uniprot/M3ZQR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/8083:dcp1b ^@ http://purl.uniprot.org/uniprot/M4A9N9 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/8083:LOC102226394 ^@ http://purl.uniprot.org/uniprot/A0A3B5R2L1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/8083:psma6 ^@ http://purl.uniprot.org/uniprot/A0A3B5R3E6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/8083:LOC102221045 ^@ http://purl.uniprot.org/uniprot/A0A3B5QRZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/8083:LOC102222607 ^@ http://purl.uniprot.org/uniprot/A0A3B5QMU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/8083:exosc2 ^@ http://purl.uniprot.org/uniprot/M3ZSU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP4 family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102219664 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CART family.|||Secreted http://togogenome.org/gene/8083:cacng1 ^@ http://purl.uniprot.org/uniprot/M3ZWH4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.|||Membrane|||Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.|||sarcolemma http://togogenome.org/gene/8083:LOC102231245 ^@ http://purl.uniprot.org/uniprot/M3ZKL6 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/8083:LOC102217573 ^@ http://purl.uniprot.org/uniprot/M4ABQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/8083:LOC102225387 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q790 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/8083:LOC102229458 ^@ http://purl.uniprot.org/uniprot/A0A3B5QCD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:vangl1 ^@ http://purl.uniprot.org/uniprot/M3ZKQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:vsx2 ^@ http://purl.uniprot.org/uniprot/M4AJ86 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:hm13 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3H3|||http://purl.uniprot.org/uniprot/A0A3B5R3W7|||http://purl.uniprot.org/uniprot/M3ZM67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Membrane http://togogenome.org/gene/8083:atp23 ^@ http://purl.uniprot.org/uniprot/M4A6X7 ^@ Similarity ^@ Belongs to the peptidase M76 family. http://togogenome.org/gene/8083:LOC102220768 ^@ http://purl.uniprot.org/uniprot/A0A3B5R5M2 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/8083:LOC102219994 ^@ http://purl.uniprot.org/uniprot/A0A3B5R2J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:LOC102233192 ^@ http://purl.uniprot.org/uniprot/A0A3B5R521 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/8083:slc39a8 ^@ http://purl.uniprot.org/uniprot/M4AJB6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102219415 ^@ http://purl.uniprot.org/uniprot/M3ZYM2 ^@ Similarity ^@ Belongs to the FAX family. http://togogenome.org/gene/8083:LOC102234311 ^@ http://purl.uniprot.org/uniprot/M4AQ18 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:sf1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q7D1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BBP/SF1 family.|||Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.|||Nucleus http://togogenome.org/gene/8083:slc25a16 ^@ http://purl.uniprot.org/uniprot/M3ZKH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:LOC102237260 ^@ http://purl.uniprot.org/uniprot/A0A3B5QDS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/8083:psma8 ^@ http://purl.uniprot.org/uniprot/M4AQD3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/8083:krr1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QL09 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KRR1 family.|||Component of the ribosomal small subunit (SSU) processome.|||Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.|||nucleolus http://togogenome.org/gene/8083:LOC102220880 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q367 ^@ Similarity ^@ Belongs to the CKAP2 family. http://togogenome.org/gene/8083:abcb7 ^@ http://purl.uniprot.org/uniprot/M4A3Q0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:grk7 ^@ http://purl.uniprot.org/uniprot/A0A3B5PU67 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/8083:rcan3 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAB3|||http://purl.uniprot.org/uniprot/M3ZZS0 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/8083:rpl7 ^@ http://purl.uniprot.org/uniprot/M4A7I8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/8083:LOC102223183 ^@ http://purl.uniprot.org/uniprot/M4AYZ2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/8083:hexdc ^@ http://purl.uniprot.org/uniprot/M4AE77 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 20 family. http://togogenome.org/gene/8083:npepl1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8H3 ^@ Similarity ^@ Belongs to the peptidase M17 family. http://togogenome.org/gene/8083:LOC102225495 ^@ http://purl.uniprot.org/uniprot/A0A3B5QNE4 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/8083:LOC102220371 ^@ http://purl.uniprot.org/uniprot/M4AGW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:LOC102223026 ^@ http://purl.uniprot.org/uniprot/M3ZRW1 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/8083:LOC102233178 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||Cytoplasm|||Major role in the synthesis of nucleoside triphosphates other than ATP.|||Nucleus|||lamellipodium|||ruffle http://togogenome.org/gene/8083:slc35a1 ^@ http://purl.uniprot.org/uniprot/M4AR54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:prr5 ^@ http://purl.uniprot.org/uniprot/M4A3V4 ^@ Similarity ^@ Belongs to the PROTOR family. http://togogenome.org/gene/8083:LOC102231176 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q517 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102225077 ^@ http://purl.uniprot.org/uniprot/M4AJR6 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/8083:LOC102233672 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBV6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:dusp7 ^@ http://purl.uniprot.org/uniprot/A0A3B5QW95 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/8083:otc ^@ http://purl.uniprot.org/uniprot/M4ABS1 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily.|||Homotrimer. http://togogenome.org/gene/8083:LOC102228614 ^@ http://purl.uniprot.org/uniprot/M3ZHZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:hspa9 ^@ http://purl.uniprot.org/uniprot/M3ZPK6 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/8083:LOC102229101 ^@ http://purl.uniprot.org/uniprot/M4B068 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102234790 ^@ http://purl.uniprot.org/uniprot/M3ZSQ5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:purb ^@ http://purl.uniprot.org/uniprot/M4B0T7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PUR DNA-binding protein family.|||Nucleus http://togogenome.org/gene/8083:vipr1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R8L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:abl1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q636 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/8083:htr1f ^@ http://purl.uniprot.org/uniprot/M4A2T8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:med8 ^@ http://purl.uniprot.org/uniprot/M3ZVV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 8 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/8083:LOC102222512 ^@ http://purl.uniprot.org/uniprot/M4A6N6 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/8083:LOC102216695 ^@ http://purl.uniprot.org/uniprot/Q8AYC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/8083:LOC102236639 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDH8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102224401 ^@ http://purl.uniprot.org/uniprot/M3ZIG4 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/8083:zic5 ^@ http://purl.uniprot.org/uniprot/M4A976 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/8083:LOC102224364 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHF7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:lrp12 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q081 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:rad23a ^@ http://purl.uniprot.org/uniprot/M4A2S2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/8083:LOC102235230 ^@ http://purl.uniprot.org/uniprot/M3ZYJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM CPSF6/7 family.|||Nucleus http://togogenome.org/gene/8083:LOC102237666 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVI8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102230598 ^@ http://purl.uniprot.org/uniprot/M4A3H7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. http://togogenome.org/gene/8083:srp19 ^@ http://purl.uniprot.org/uniprot/A0A3B5RF90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP19 family.|||Cytoplasm http://togogenome.org/gene/8083:fam118b ^@ http://purl.uniprot.org/uniprot/M3ZGJ7 ^@ Similarity ^@ Belongs to the FAM118 family. http://togogenome.org/gene/8083:LOC102233057 ^@ http://purl.uniprot.org/uniprot/M4A973 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Endosome|||Heterooligomeric complex.|||Membrane http://togogenome.org/gene/8083:vwa2 ^@ http://purl.uniprot.org/uniprot/M4A0X1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:hacd1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R8R1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102233407 ^@ http://purl.uniprot.org/uniprot/M4B0J9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102226323 ^@ http://purl.uniprot.org/uniprot/M3ZX23 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.|||Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. http://togogenome.org/gene/8083:alg9 ^@ http://purl.uniprot.org/uniprot/M4A8C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:rps13 ^@ http://purl.uniprot.org/uniprot/M4AD41 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/8083:LOC102231571 ^@ http://purl.uniprot.org/uniprot/M4A830 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/8083:LOC102233247 ^@ http://purl.uniprot.org/uniprot/M3ZYT5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/8083:lbh ^@ http://purl.uniprot.org/uniprot/M4A5G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LBH family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:c8b ^@ http://purl.uniprot.org/uniprot/M4AUW4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:pex3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QXG4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with PEX19.|||Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.|||Peroxisome membrane http://togogenome.org/gene/8083:LOC102224425 ^@ http://purl.uniprot.org/uniprot/M3ZE74 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/8083:orc4 ^@ http://purl.uniprot.org/uniprot/M4A861 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC4 family.|||Component of the origin recognition complex (ORC) that binds origins of replication.|||Nucleus http://togogenome.org/gene/8083:LOC102233833 ^@ http://purl.uniprot.org/uniprot/M4A392 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/8083:cdca7l ^@ http://purl.uniprot.org/uniprot/M3ZED7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/8083:szrd1 ^@ http://purl.uniprot.org/uniprot/M4AQK4 ^@ Similarity ^@ Belongs to the SZRD1 family. http://togogenome.org/gene/8083:LOC102236747 ^@ http://purl.uniprot.org/uniprot/A0A3B5PV05 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/8083:aurka ^@ http://purl.uniprot.org/uniprot/M3ZV48 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. http://togogenome.org/gene/8083:LOC102216516 ^@ http://purl.uniprot.org/uniprot/A0A3B5R908 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/8083:LOC102238396 ^@ http://purl.uniprot.org/uniprot/M4ATQ9 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/8083:LOC102226407 ^@ http://purl.uniprot.org/uniprot/M4A9R0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:ppih ^@ http://purl.uniprot.org/uniprot/A0A3B5PUT6 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/8083:LOC102227648 ^@ http://purl.uniprot.org/uniprot/M3ZSQ0 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasmic vesicle membrane|||Interacts with ARF6.|||Membrane|||Presynapse http://togogenome.org/gene/8083:LOC102236328 ^@ http://purl.uniprot.org/uniprot/A0A3B5R650 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/8083:LOC102233077 ^@ http://purl.uniprot.org/uniprot/M3ZGY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/8083:csgalnact1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/8083:dcp2 ^@ http://purl.uniprot.org/uniprot/M3ZZL0 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DCP2 subfamily. http://togogenome.org/gene/8083:sub1 ^@ http://purl.uniprot.org/uniprot/M4AFX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transcriptional coactivator PC4 family.|||General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).|||Nucleus http://togogenome.org/gene/8083:LOC102219138 ^@ http://purl.uniprot.org/uniprot/A0A3B5QEU2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:rad9a ^@ http://purl.uniprot.org/uniprot/M4A625 ^@ Similarity ^@ Belongs to the rad9 family. http://togogenome.org/gene/8083:ssbp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PYJ8 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/8083:ndufb4 ^@ http://purl.uniprot.org/uniprot/M4AX58 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB4 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102216981 ^@ http://purl.uniprot.org/uniprot/A0A3B5R002 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm http://togogenome.org/gene/8083:ampd3 ^@ http://purl.uniprot.org/uniprot/M4A4F7 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/8083:wdyhv1 ^@ http://purl.uniprot.org/uniprot/M4AT84 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NTAQ1 family.|||Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.|||Monomer. http://togogenome.org/gene/8083:nmt1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QUK5 ^@ Function|||Similarity ^@ Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.|||Belongs to the NMT family. http://togogenome.org/gene/8083:mthfr ^@ http://purl.uniprot.org/uniprot/M4AE75 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/8083:LOC102226624 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q5Y6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:mus81 ^@ http://purl.uniprot.org/uniprot/M4A614 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPF family.|||Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).|||Interacts with EME1.|||Nucleus http://togogenome.org/gene/8083:ube2g1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q282 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:LOC102230594 ^@ http://purl.uniprot.org/uniprot/M3ZV01 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:panx2 ^@ http://purl.uniprot.org/uniprot/M4AXQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/8083:LOC102224818 ^@ http://purl.uniprot.org/uniprot/M4A6Q8 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/8083:rps3a ^@ http://purl.uniprot.org/uniprot/M4A0X4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).|||Cytoplasm|||nucleolus http://togogenome.org/gene/8083:map2k4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QYL4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:entpd1 ^@ http://purl.uniprot.org/uniprot/M4APA6 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/8083:cmc2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QS44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/8083:nap1l1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QD38|||http://purl.uniprot.org/uniprot/A0A3B5QHU7 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/8083:arf1 ^@ http://purl.uniprot.org/uniprot/M3ZUA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/8083:LOC102217732 ^@ http://purl.uniprot.org/uniprot/M4APG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:ech1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAP7 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/8083:flot2 ^@ http://purl.uniprot.org/uniprot/A0A3B5R4Z4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Endosome|||Heterooligomeric complex.|||Membrane http://togogenome.org/gene/8083:hnrnpk ^@ http://purl.uniprot.org/uniprot/M4AKT1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||nucleoplasm http://togogenome.org/gene/8083:LOC102231621 ^@ http://purl.uniprot.org/uniprot/M4ACX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WFIKKN family.|||Membrane|||Secreted http://togogenome.org/gene/8083:becn1 ^@ http://purl.uniprot.org/uniprot/M4A689 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beclin family.|||Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Mitochondrion membrane|||autophagosome|||trans-Golgi network membrane http://togogenome.org/gene/8083:gng10 ^@ http://purl.uniprot.org/uniprot/M4AGS3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/8083:LOC102223392 ^@ http://purl.uniprot.org/uniprot/M3ZG04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102225603 ^@ http://purl.uniprot.org/uniprot/M4AY51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 6c family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102233316 ^@ http://purl.uniprot.org/uniprot/M4A2Z7 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/8083:isca1 ^@ http://purl.uniprot.org/uniprot/M3ZKP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/8083:tubd1 ^@ http://purl.uniprot.org/uniprot/M4ARB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Nucleus|||centriole|||cilium http://togogenome.org/gene/8083:plpp2 ^@ http://purl.uniprot.org/uniprot/M4A4N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/8083:kynu ^@ http://purl.uniprot.org/uniprot/M4A805 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102236299 ^@ http://purl.uniprot.org/uniprot/M4ANE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/8083:acsl3 ^@ http://purl.uniprot.org/uniprot/M4A1F3 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/8083:LOC102224245 ^@ http://purl.uniprot.org/uniprot/M3ZG63 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/8083:LOC102226168 ^@ http://purl.uniprot.org/uniprot/M4AIM0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. http://togogenome.org/gene/8083:gss ^@ http://purl.uniprot.org/uniprot/M4APL4 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic GSH synthase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/8083:hint3 ^@ http://purl.uniprot.org/uniprot/M4A2M6 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/8083:dgcr2 ^@ http://purl.uniprot.org/uniprot/A0A3B5R2U7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:zmpste24 ^@ http://purl.uniprot.org/uniprot/M4A000 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48A family.|||Binds 1 zinc ion per subunit.|||Endoplasmic reticulum membrane|||Proteolytically removes the C-terminal three residues of farnesylated proteins. http://togogenome.org/gene/8083:LOC102235796 ^@ http://purl.uniprot.org/uniprot/M3ZXU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/8083:dbh ^@ http://purl.uniprot.org/uniprot/M3ZH72 ^@ Similarity ^@ Belongs to the copper type II ascorbate-dependent monooxygenase family. http://togogenome.org/gene/8083:LOC102229617 ^@ http://purl.uniprot.org/uniprot/A0A3B5PN27 ^@ Similarity ^@ Belongs to the ubiquitin family. http://togogenome.org/gene/8083:polr3c ^@ http://purl.uniprot.org/uniprot/M4AP79 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/8083:LOC102234738 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q6S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/8083:clcn5 ^@ http://purl.uniprot.org/uniprot/M4AKQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/8083:gmppb ^@ http://purl.uniprot.org/uniprot/M4AFZ3 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/8083:nop14 ^@ http://purl.uniprot.org/uniprot/M4AI90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP14 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.|||nucleolus http://togogenome.org/gene/8083:kcnmb2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PWN3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102220240 ^@ http://purl.uniprot.org/uniprot/A0A3B5R308 ^@ Similarity ^@ Belongs to the TAF9 family. CENP-S/MHF1 subfamily. http://togogenome.org/gene/8083:KEG86_p07 ^@ http://purl.uniprot.org/uniprot/B5WZ57 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane http://togogenome.org/gene/8083:LOC102234870 ^@ http://purl.uniprot.org/uniprot/A0A3B5R4I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/8083:LOC102220509 ^@ http://purl.uniprot.org/uniprot/M3ZXI5 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/8083:LOC102226300 ^@ http://purl.uniprot.org/uniprot/M4A3S0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/8083:aldh4a1 ^@ http://purl.uniprot.org/uniprot/M4ADS8 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/8083:gldc ^@ http://purl.uniprot.org/uniprot/A0A3B5QTW3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvP family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/8083:KEG86_p02 ^@ http://purl.uniprot.org/uniprot/B5WZ62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Belongs to the complex I subunit 6 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion membrane http://togogenome.org/gene/8083:wnt6 ^@ http://purl.uniprot.org/uniprot/M3ZHV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/8083:LOC102222422 ^@ http://purl.uniprot.org/uniprot/M4AG80 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/8083:reep6 ^@ http://purl.uniprot.org/uniprot/A0A3B5QFU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/8083:LOC102235555 ^@ http://purl.uniprot.org/uniprot/A0A3B5QK00|||http://purl.uniprot.org/uniprot/M3ZHX6 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/8083:LOC102222087 ^@ http://purl.uniprot.org/uniprot/M3ZNK0 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/8083:cmpk1 ^@ http://purl.uniprot.org/uniprot/M3ZQI2 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.|||Binds 1 Mg(2+) ion per monomer.|||Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/8083:mfap1 ^@ http://purl.uniprot.org/uniprot/M4AUM7 ^@ Function|||Similarity ^@ Belongs to the MFAP1 family.|||Involved in pre-mRNA splicing as a component of the spliceosome. http://togogenome.org/gene/8083:LOC102226756 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDY2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:slc7a6os ^@ http://purl.uniprot.org/uniprot/M4ACC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IWR1/SLC7A6OS family.|||Cytoplasm|||Directs RNA polymerase II nuclear import.|||Nucleus http://togogenome.org/gene/8083:LOC102231048 ^@ http://purl.uniprot.org/uniprot/M4ABJ5 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/8083:gins4 ^@ http://purl.uniprot.org/uniprot/M3ZI36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS4/SLD5 family.|||Chromosome|||Nucleus|||Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/8083:LOC102217503 ^@ http://purl.uniprot.org/uniprot/M4A6X8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/8083:ilk ^@ http://purl.uniprot.org/uniprot/M3ZS50 ^@ Subcellular Location Annotation ^@ lamellipodium|||sarcomere http://togogenome.org/gene/8083:LOC102228075 ^@ http://purl.uniprot.org/uniprot/M4A1H3 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/8083:LOC102224144 ^@ http://purl.uniprot.org/uniprot/M3ZIC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NFX1 family.|||Nucleus http://togogenome.org/gene/8083:LOC102220977 ^@ http://purl.uniprot.org/uniprot/M4AJK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/8083:tns3 ^@ http://purl.uniprot.org/uniprot/M4AR09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/8083:LOC102232002 ^@ http://purl.uniprot.org/uniprot/M4AK39 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/8083:kmt5a ^@ http://purl.uniprot.org/uniprot/M3ZIU2 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/8083:stambpl1 ^@ http://purl.uniprot.org/uniprot/M4AM44 ^@ Similarity ^@ Belongs to the peptidase M67C family. http://togogenome.org/gene/8083:LOC102226519 ^@ http://purl.uniprot.org/uniprot/M3ZFS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin heavy chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||Membrane|||coated pit http://togogenome.org/gene/8083:myd88 ^@ http://purl.uniprot.org/uniprot/A0A3B5QX11 ^@ Function|||Subcellular Location Annotation ^@ Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.|||Cytoplasm http://togogenome.org/gene/8083:LOC102229095 ^@ http://purl.uniprot.org/uniprot/M4ACD6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/8083:dlx3 ^@ http://purl.uniprot.org/uniprot/M4AKJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/8083:got1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAR0 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/8083:LOC102227045 ^@ http://purl.uniprot.org/uniprot/M4A1D7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.|||Membrane http://togogenome.org/gene/8083:ube3d ^@ http://purl.uniprot.org/uniprot/M3ZXU8 ^@ Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. http://togogenome.org/gene/8083:LOC102237336 ^@ http://purl.uniprot.org/uniprot/A0A3B5PZA5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/8083:LOC102237741 ^@ http://purl.uniprot.org/uniprot/M4ALZ3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:foxn2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVU0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:ppp1r14c ^@ http://purl.uniprot.org/uniprot/A0A3B5PTW7 ^@ Similarity ^@ Belongs to the PP1 inhibitor family. http://togogenome.org/gene/8083:LOC102234645 ^@ http://purl.uniprot.org/uniprot/A0A3B5QG10 ^@ Similarity ^@ Belongs to the IUNH family. http://togogenome.org/gene/8083:LOC102227558 ^@ http://purl.uniprot.org/uniprot/M3ZKT0 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/8083:ms4a12 ^@ http://purl.uniprot.org/uniprot/M4ANJ2 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/8083:LOC102224857 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBQ2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/8083:LOC102236278 ^@ http://purl.uniprot.org/uniprot/A0A3B5R2D8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Endosome|||Heterooligomeric complex.|||Membrane http://togogenome.org/gene/8083:LOC102232732 ^@ http://purl.uniprot.org/uniprot/A0A3B5PU19 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/8083:LOC102218937 ^@ http://purl.uniprot.org/uniprot/M4ANG6 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/8083:tacc1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PYE7|||http://purl.uniprot.org/uniprot/A0A3B5QXN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACC family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102236496 ^@ http://purl.uniprot.org/uniprot/M4AQN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane http://togogenome.org/gene/8083:LOC102231628 ^@ http://purl.uniprot.org/uniprot/M4AJB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/8083:smim15 ^@ http://purl.uniprot.org/uniprot/M4B0X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM15 family.|||Membrane http://togogenome.org/gene/8083:dbndd1 ^@ http://purl.uniprot.org/uniprot/M3ZLH4 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/8083:nab2 ^@ http://purl.uniprot.org/uniprot/M3ZN04 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAB family.|||Homomultimers may associate with EGR1 bound to DNA.|||Nucleus http://togogenome.org/gene/8083:lhx6 ^@ http://purl.uniprot.org/uniprot/M3ZMW8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102226969 ^@ http://purl.uniprot.org/uniprot/M4A167 ^@ Similarity ^@ Belongs to the dapper family. http://togogenome.org/gene/8083:hsd3b7 ^@ http://purl.uniprot.org/uniprot/M4A0P0 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/8083:LOC102229434 ^@ http://purl.uniprot.org/uniprot/M4ALG0 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Contains one covalently linked retinal chromophore.|||Membrane http://togogenome.org/gene/8083:thbs3 ^@ http://purl.uniprot.org/uniprot/M3ZSA0 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:atp2a3 ^@ http://purl.uniprot.org/uniprot/M3ZUE8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/8083:optn ^@ http://purl.uniprot.org/uniprot/M4A2F1 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Golgi apparatus|||May act by regulating membrane trafficking and cellular morphogenesis.|||Recycling endosome|||autophagosome|||perinuclear region|||trans-Golgi network http://togogenome.org/gene/8083:psmc5 ^@ http://purl.uniprot.org/uniprot/M4AR95 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/8083:dync2li1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light intermediate chain family.|||centrosome|||cilium|||cilium axoneme|||cilium basal body http://togogenome.org/gene/8083:LOC102227448 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9I7 ^@ Similarity ^@ Belongs to the neuritin family. http://togogenome.org/gene/8083:LOC102234230 ^@ http://purl.uniprot.org/uniprot/M3ZVU2 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/8083:pcmtd1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PX87 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/8083:LOC102231045 ^@ http://purl.uniprot.org/uniprot/M3ZTZ8 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/8083:adgra1 ^@ http://purl.uniprot.org/uniprot/M3ZZG2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:praf2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PS71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/8083:tlcd2 ^@ http://purl.uniprot.org/uniprot/M4A2A7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102228533 ^@ http://purl.uniprot.org/uniprot/M4AMF1 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/8083:LOC102220277 ^@ http://purl.uniprot.org/uniprot/M4A7N5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102219903 ^@ http://purl.uniprot.org/uniprot/M4AUG8 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/8083:ccdc124 ^@ http://purl.uniprot.org/uniprot/A0A3B5R9B5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC124 family.|||Midbody http://togogenome.org/gene/8083:LOC102216738 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8G3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 23 family. http://togogenome.org/gene/8083:copb1 ^@ http://purl.uniprot.org/uniprot/M3ZXW0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/8083:slc17a6 ^@ http://purl.uniprot.org/uniprot/M3ZXT4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:slc6a1 ^@ http://purl.uniprot.org/uniprot/M4ASR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/8083:dirc2 ^@ http://purl.uniprot.org/uniprot/M3ZF51 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:gal3st3 ^@ http://purl.uniprot.org/uniprot/M4A1Q3 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/8083:LOC102233933 ^@ http://purl.uniprot.org/uniprot/M3ZWJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/8083:tmem269 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZ15 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/8083:tyr ^@ http://purl.uniprot.org/uniprot/M4A9U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/8083:LOC102218482 ^@ http://purl.uniprot.org/uniprot/M4AIZ4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/8083:LOC102222783 ^@ http://purl.uniprot.org/uniprot/M3ZK30 ^@ Similarity|||Subunit ^@ Belongs to the 14-3-3 family.|||Homodimer, and heterodimer with other family members. http://togogenome.org/gene/8083:LOC102228267 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/8083:npvf ^@ http://purl.uniprot.org/uniprot/M3ZFK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FARP (FMRFamide related peptide) family.|||Secreted http://togogenome.org/gene/8083:LOC102231781 ^@ http://purl.uniprot.org/uniprot/A0A3B5RB51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/8083:mtfr1l ^@ http://purl.uniprot.org/uniprot/M3ZIU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/8083:LOC102228643 ^@ http://purl.uniprot.org/uniprot/A0A3B5PP47 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/8083:LOC102236136 ^@ http://purl.uniprot.org/uniprot/M3ZKQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:LOC102233281 ^@ http://purl.uniprot.org/uniprot/M4B027 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:spon2 ^@ http://purl.uniprot.org/uniprot/M4A2S4 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/8083:ak1 ^@ http://purl.uniprot.org/uniprot/M4AA20 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK1 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer. http://togogenome.org/gene/8083:htr5a ^@ http://purl.uniprot.org/uniprot/A0A3B5R344 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102230468 ^@ http://purl.uniprot.org/uniprot/M4ARY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:iws1 ^@ http://purl.uniprot.org/uniprot/M4AK28 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:cd82 ^@ http://purl.uniprot.org/uniprot/A0A3B5QU50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:LOC102233154 ^@ http://purl.uniprot.org/uniprot/M4AFT5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:sec11a ^@ http://purl.uniprot.org/uniprot/M4ARS6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:maml3 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q4H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mastermind family.|||Nucleus speckle http://togogenome.org/gene/8083:LOC102223931 ^@ http://purl.uniprot.org/uniprot/M3ZGK9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:mapkap1 ^@ http://purl.uniprot.org/uniprot/A0A3B5RE54 ^@ Similarity ^@ Belongs to the SIN1 family. http://togogenome.org/gene/8083:LOC102217139 ^@ http://purl.uniprot.org/uniprot/A0A3B5RE79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/8083:LOC102217883 ^@ http://purl.uniprot.org/uniprot/M3ZD30 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:psmd13 ^@ http://purl.uniprot.org/uniprot/M4AVF2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S11 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/8083:wnt1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QXD5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/8083:LOC102219125 ^@ http://purl.uniprot.org/uniprot/M4AXD1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Monomer. Homodimer; disulfide-linked.|||Secreted|||The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.|||The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.|||The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. http://togogenome.org/gene/8083:pcyt2 ^@ http://purl.uniprot.org/uniprot/M4AET6 ^@ Similarity ^@ Belongs to the cytidylyltransferase family. http://togogenome.org/gene/8083:LOC102233196 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQI1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8083:aars2 ^@ http://purl.uniprot.org/uniprot/M4A2W7 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Monomer. Interacts with ANKRD16; the interaction is direct. http://togogenome.org/gene/8083:LOC102228842 ^@ http://purl.uniprot.org/uniprot/M3ZJ31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/8083:LOC102219987 ^@ http://purl.uniprot.org/uniprot/A0A3B5QJI5 ^@ Function|||Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. http://togogenome.org/gene/8083:wisp3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QB46 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:rbm8a ^@ http://purl.uniprot.org/uniprot/M4AGA0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBM8A family.|||Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.|||Cytoplasm|||Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.|||Nucleus|||Nucleus speckle http://togogenome.org/gene/8083:adamts15 ^@ http://purl.uniprot.org/uniprot/M4AD19 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/8083:LOC102223990 ^@ http://purl.uniprot.org/uniprot/Q90XF7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Homodimer.|||It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.|||Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. http://togogenome.org/gene/8083:LOC102226736 ^@ http://purl.uniprot.org/uniprot/A0A3B5QER5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADRM1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102216642 ^@ http://purl.uniprot.org/uniprot/M4AX99 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/8083:LOC102216565 ^@ http://purl.uniprot.org/uniprot/M4AWB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. http://togogenome.org/gene/8083:castor1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PXF7 ^@ Similarity ^@ Belongs to the GATS family. http://togogenome.org/gene/8083:snx18 ^@ http://purl.uniprot.org/uniprot/M4A6Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/8083:LOC102231980 ^@ http://purl.uniprot.org/uniprot/M3ZKL0 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/8083:impad1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QW21 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/8083:zdhhc8 ^@ http://purl.uniprot.org/uniprot/M3ZJR1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/8083:hnrnpab ^@ http://purl.uniprot.org/uniprot/M4A3D3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/8083:msh6 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDU5 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||Component of the post-replicative DNA mismatch repair system (MMR). http://togogenome.org/gene/8083:dscc1 ^@ http://purl.uniprot.org/uniprot/M4A8T5 ^@ Similarity ^@ Belongs to the DCC1 family. http://togogenome.org/gene/8083:LOC102236332 ^@ http://purl.uniprot.org/uniprot/M4ARA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/8083:neu1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R9D4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/8083:LOC102227392 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q236 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/8083:dennd6b ^@ http://purl.uniprot.org/uniprot/M4ALH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND6 family.|||Recycling endosome http://togogenome.org/gene/8083:LOC102218022 ^@ http://purl.uniprot.org/uniprot/A0A3B5QMB8 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/8083:gas6 ^@ http://purl.uniprot.org/uniprot/M4AXW0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:mthfd1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAV7 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.|||In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. http://togogenome.org/gene/8083:podxl ^@ http://purl.uniprot.org/uniprot/A0A3B5Q7W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the podocalyxin family.|||Cell membrane|||Membrane|||Membrane raft|||filopodium|||lamellipodium|||microvillus|||ruffle http://togogenome.org/gene/8083:strada ^@ http://purl.uniprot.org/uniprot/A0A3B5RBD6 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. http://togogenome.org/gene/8083:LOC102222953 ^@ http://purl.uniprot.org/uniprot/M3ZKV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ODF2 family.|||centrosome http://togogenome.org/gene/8083:trdn ^@ http://purl.uniprot.org/uniprot/A0A3B5QBZ8 ^@ Subcellular Location Annotation ^@ Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/8083:LOC102237423 ^@ http://purl.uniprot.org/uniprot/A0A3B5PZF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin basic protein family.|||Myelin membrane http://togogenome.org/gene/8083:LOC102232137 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGL0 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/8083:ndrg3 ^@ http://purl.uniprot.org/uniprot/A0A3B5R052|||http://purl.uniprot.org/uniprot/A0A3B5R3J6 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/8083:LOC102238407 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3H9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/8083:LOC102221613 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Membrane|||Recycling endosome membrane http://togogenome.org/gene/8083:LOC102221730 ^@ http://purl.uniprot.org/uniprot/A0A3B5QKP5 ^@ Similarity|||Subunit ^@ Belongs to the 14-3-3 family.|||Homodimer, and heterodimer with other family members. http://togogenome.org/gene/8083:arl8b ^@ http://purl.uniprot.org/uniprot/M4A0X2 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/8083:LOC102225230 ^@ http://purl.uniprot.org/uniprot/M4AH75 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/8083:boc ^@ http://purl.uniprot.org/uniprot/A0A3B5QW14 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:faah2 ^@ http://purl.uniprot.org/uniprot/M3ZHV1 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/8083:ap2s1 ^@ http://purl.uniprot.org/uniprot/M3ZPU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cell membrane|||coated pit http://togogenome.org/gene/8083:cnn1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PQ98 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/8083:LOC102227899 ^@ http://purl.uniprot.org/uniprot/M4AF30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:ppp2r5c ^@ http://purl.uniprot.org/uniprot/A0A3B5QGN3|||http://purl.uniprot.org/uniprot/M3ZZX6 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family. http://togogenome.org/gene/8083:LOC102232347 ^@ http://purl.uniprot.org/uniprot/M4AX95 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/8083:tgfa ^@ http://purl.uniprot.org/uniprot/M4AM23 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:ednra ^@ http://purl.uniprot.org/uniprot/M4A580 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/8083:pi4k2b ^@ http://purl.uniprot.org/uniprot/M3ZTP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.|||Membrane http://togogenome.org/gene/8083:LOC102238117 ^@ http://purl.uniprot.org/uniprot/M4ALB0 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/8083:LOC102229605 ^@ http://purl.uniprot.org/uniprot/M4AHX7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphatidyl serine synthase family.|||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:sigirr ^@ http://purl.uniprot.org/uniprot/A0A3B5R4C5 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/8083:LOC102233859 ^@ http://purl.uniprot.org/uniprot/A0A3B5QT79 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/8083:bnip1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QBK2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102230236 ^@ http://purl.uniprot.org/uniprot/M4AF85 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/8083:eya4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QYA2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/8083:LOC102220267 ^@ http://purl.uniprot.org/uniprot/M3ZDQ9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:slc25a20 ^@ http://purl.uniprot.org/uniprot/M4AQT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:emsy ^@ http://purl.uniprot.org/uniprot/M4AAA3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102236910 ^@ http://purl.uniprot.org/uniprot/M3ZLR7 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/8083:LOC102237592 ^@ http://purl.uniprot.org/uniprot/A0A3B5QUT0 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:c8a ^@ http://purl.uniprot.org/uniprot/M4AUS9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:bora ^@ http://purl.uniprot.org/uniprot/M4AUV4 ^@ Similarity ^@ Belongs to the BORA family. http://togogenome.org/gene/8083:LOC102218546 ^@ http://purl.uniprot.org/uniprot/M3ZKC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/8083:LOC102220269 ^@ http://purl.uniprot.org/uniprot/M4AIV9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/8083:cdh18 ^@ http://purl.uniprot.org/uniprot/M4AIP4 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/8083:mthfs ^@ http://purl.uniprot.org/uniprot/M4B011 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/8083:LOC102236771 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWH3 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/8083:LOC102230672 ^@ http://purl.uniprot.org/uniprot/M3ZFT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:six1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QH22 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:cog2 ^@ http://purl.uniprot.org/uniprot/M4AV38 ^@ Similarity ^@ Belongs to the COG2 family. http://togogenome.org/gene/8083:LOC102227670 ^@ http://purl.uniprot.org/uniprot/A0A3B5QUE9 ^@ Similarity ^@ Belongs to the STRIP family. http://togogenome.org/gene/8083:uba3 ^@ http://purl.uniprot.org/uniprot/M4A7S1 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. UBA3 subfamily. http://togogenome.org/gene/8083:LOC102233967 ^@ http://purl.uniprot.org/uniprot/M4A271 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/8083:LOC102221593 ^@ http://purl.uniprot.org/uniprot/A0A3B5QCY7 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/8083:lck ^@ http://purl.uniprot.org/uniprot/M4AX24 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/8083:dapk2 ^@ http://purl.uniprot.org/uniprot/M3ZMC5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:LOC102233342 ^@ http://purl.uniprot.org/uniprot/M3ZZQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clusterin family.|||Endoplasmic reticulum|||Membrane|||Mitochondrion membrane|||Nucleus|||Secreted|||chromaffin granule|||cytosol http://togogenome.org/gene/8083:samd4b ^@ http://purl.uniprot.org/uniprot/A0A3B5RCC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMAUG family.|||Cytoplasm http://togogenome.org/gene/8083:gsx2 ^@ http://purl.uniprot.org/uniprot/M4AIT7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:taf1b ^@ http://purl.uniprot.org/uniprot/M4A602 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRN7/TAF1B family.|||nucleolus http://togogenome.org/gene/8083:LOC102218524 ^@ http://purl.uniprot.org/uniprot/M4AZL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/8083:LOC102226015 ^@ http://purl.uniprot.org/uniprot/M3ZHG6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102227213 ^@ http://purl.uniprot.org/uniprot/M4AHQ1 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/8083:sae1 ^@ http://purl.uniprot.org/uniprot/M3ZP32 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/8083:ykt6 ^@ http://purl.uniprot.org/uniprot/M4A6L7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. http://togogenome.org/gene/8083:LOC102223020 ^@ http://purl.uniprot.org/uniprot/M4AY73 ^@ Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family. http://togogenome.org/gene/8083:cog1 ^@ http://purl.uniprot.org/uniprot/M3ZYB7 ^@ Similarity ^@ Belongs to the COG1 family. http://togogenome.org/gene/8083:LOC102235973 ^@ http://purl.uniprot.org/uniprot/M4A5Z1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.|||Cytoplasm|||Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Nucleus|||nucleolus http://togogenome.org/gene/8083:LOC102234938 ^@ http://purl.uniprot.org/uniprot/M3ZWH2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:atp6v1c1 ^@ http://purl.uniprot.org/uniprot/M3ZJK1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/8083:tmod3 ^@ http://purl.uniprot.org/uniprot/M3ZIY3 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/8083:LOC106699759 ^@ http://purl.uniprot.org/uniprot/M3ZJ67 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/8083:pfdn1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R3C3 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/8083:LOC102220030 ^@ http://purl.uniprot.org/uniprot/M3ZVK9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:creld1 ^@ http://purl.uniprot.org/uniprot/M4ASQ5 ^@ Caution|||Similarity ^@ Belongs to the CRELD family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102232459 ^@ http://purl.uniprot.org/uniprot/M4AII5 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8083:LOC102227926 ^@ http://purl.uniprot.org/uniprot/A0A3B5QH60|||http://purl.uniprot.org/uniprot/M4AS54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Membrane|||axon|||cytoskeleton|||synaptosome http://togogenome.org/gene/8083:sptlc3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QSU1 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/8083:LOC102236491 ^@ http://purl.uniprot.org/uniprot/M3ZPJ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102233723 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0P9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:ppp4r3b ^@ http://purl.uniprot.org/uniprot/M4AR40 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/8083:dnajc25 ^@ http://purl.uniprot.org/uniprot/M3ZHD4 ^@ Similarity ^@ Belongs to the DNAJC25 family. http://togogenome.org/gene/8083:sms ^@ http://purl.uniprot.org/uniprot/A0A3B5QU47 ^@ Similarity ^@ Belongs to the spermidine/spermine synthase family. http://togogenome.org/gene/8083:irf9 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q6W1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102234104 ^@ http://purl.uniprot.org/uniprot/M3ZRK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/8083:LOC102224810 ^@ http://purl.uniprot.org/uniprot/M4AJN0 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8083:dct ^@ http://purl.uniprot.org/uniprot/M3ZQV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/8083:faah ^@ http://purl.uniprot.org/uniprot/M4AFJ7 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/8083:ptx3 ^@ http://purl.uniprot.org/uniprot/M4ARX2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102229443 ^@ http://purl.uniprot.org/uniprot/M3ZMK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/8083:LOC102231457 ^@ http://purl.uniprot.org/uniprot/A0A3B5R6K5 ^@ Similarity ^@ Belongs to the pellino family. http://togogenome.org/gene/8083:ppard ^@ http://purl.uniprot.org/uniprot/M4A7P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/8083:LOC102232275 ^@ http://purl.uniprot.org/uniprot/M4A4S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/8083:clic4 ^@ http://purl.uniprot.org/uniprot/M4AWP5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/8083:LOC102222663 ^@ http://purl.uniprot.org/uniprot/M3ZV93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/8083:lhfpl6 ^@ http://purl.uniprot.org/uniprot/A0A3B5RE21 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:pex13 ^@ http://purl.uniprot.org/uniprot/M3ZYV3 ^@ Similarity ^@ Belongs to the peroxin-13 family. http://togogenome.org/gene/8083:LOC102234102 ^@ http://purl.uniprot.org/uniprot/A0A3B5QRK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.|||Membrane|||Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. http://togogenome.org/gene/8083:LOC102232274 ^@ http://purl.uniprot.org/uniprot/A0A3B5QW76 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/8083:LOC102224436 ^@ http://purl.uniprot.org/uniprot/M4B0T0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:eloa ^@ http://purl.uniprot.org/uniprot/M4API7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102221233 ^@ http://purl.uniprot.org/uniprot/M4ADN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:LOC102237439 ^@ http://purl.uniprot.org/uniprot/A0A3B5QLD9 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/8083:ptgfr ^@ http://purl.uniprot.org/uniprot/M4AFE8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:tpi1 ^@ http://purl.uniprot.org/uniprot/Q90XF8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Homodimer.|||It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.|||Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. http://togogenome.org/gene/8083:LOC102229836 ^@ http://purl.uniprot.org/uniprot/M3ZYT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:atf7ip ^@ http://purl.uniprot.org/uniprot/A0A3B5RED6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCAF family.|||Nucleus http://togogenome.org/gene/8083:LOC102232881 ^@ http://purl.uniprot.org/uniprot/A0A3B5QMR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM198 family.|||Membrane http://togogenome.org/gene/8083:ppp1r9a ^@ http://purl.uniprot.org/uniprot/M3ZER8 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/8083:LOC102234201 ^@ http://purl.uniprot.org/uniprot/M4AVC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/8083:LOC102220936 ^@ http://purl.uniprot.org/uniprot/M4AB83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/8083:whamm ^@ http://purl.uniprot.org/uniprot/M3ZIN0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:arl5a ^@ http://purl.uniprot.org/uniprot/A0A3B5PSJ6 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/8083:LOC102217612 ^@ http://purl.uniprot.org/uniprot/A0A3B5RF70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATXN1 family.|||Nucleus http://togogenome.org/gene/8083:LOC102227957 ^@ http://purl.uniprot.org/uniprot/M4AHS2 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/8083:LOC102238237 ^@ http://purl.uniprot.org/uniprot/M3ZY06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:LOC102216640 ^@ http://purl.uniprot.org/uniprot/M4B0N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:ube2h ^@ http://purl.uniprot.org/uniprot/A0A3B5QGN4 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:clta ^@ http://purl.uniprot.org/uniprot/A0A3B5Q862|||http://purl.uniprot.org/uniprot/A0A3B5RE03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/8083:LOC102224915 ^@ http://purl.uniprot.org/uniprot/M4ALU2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102227279 ^@ http://purl.uniprot.org/uniprot/M4AJW8 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/8083:elof1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R1A4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELOF1 family.|||Nucleus|||Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. http://togogenome.org/gene/8083:sod3 ^@ http://purl.uniprot.org/uniprot/M3ZU58 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/8083:LOC102237615 ^@ http://purl.uniprot.org/uniprot/A0A3B5QBG8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/8083:gtf2h4 ^@ http://purl.uniprot.org/uniprot/M4AGE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.|||Nucleus http://togogenome.org/gene/8083:LOC102225266 ^@ http://purl.uniprot.org/uniprot/M3ZH42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/8083:pcnx3 ^@ http://purl.uniprot.org/uniprot/M4A982 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/8083:en2 ^@ http://purl.uniprot.org/uniprot/M3ZJV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Engrailed homeobox family.|||Nucleus http://togogenome.org/gene/8083:ssr2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZM0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-beta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/8083:nfs1 ^@ http://purl.uniprot.org/uniprot/M3ZUZ7 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/8083:bpnt1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q2Q7 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/8083:LOC102238314 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9M8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/8083:cth ^@ http://purl.uniprot.org/uniprot/M3ZTF0 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/8083:cenpk ^@ http://purl.uniprot.org/uniprot/M3ZD45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-K/MCM22 family.|||Nucleus|||centromere http://togogenome.org/gene/8083:LOC102232140 ^@ http://purl.uniprot.org/uniprot/M3ZGW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mical family.|||Cytoplasm http://togogenome.org/gene/8083:hspb1 ^@ http://purl.uniprot.org/uniprot/A0A3B5RCU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||spindle http://togogenome.org/gene/8083:LOC102217836 ^@ http://purl.uniprot.org/uniprot/M4AX26 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Plays an important role in regulating the size of autophagosomes during the formation process. http://togogenome.org/gene/8083:polr1e ^@ http://purl.uniprot.org/uniprot/M4ADH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.|||nucleolus http://togogenome.org/gene/8083:LOC102234019 ^@ http://purl.uniprot.org/uniprot/M3ZZ60 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the aldo/keto reductase family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/8083:LOC102236145 ^@ http://purl.uniprot.org/uniprot/A0A3B5QST9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIP3 family.|||Membrane http://togogenome.org/gene/8083:LOC102219932 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWN2 ^@ Similarity ^@ Belongs to the CCDC90 family. http://togogenome.org/gene/8083:dpyd ^@ http://purl.uniprot.org/uniprot/M4AW59 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the dihydropyrimidine dehydrogenase family.|||Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.|||Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. http://togogenome.org/gene/8083:tmem214 ^@ http://purl.uniprot.org/uniprot/M4AFB9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TMEM214 family.|||Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.|||Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102231602 ^@ http://purl.uniprot.org/uniprot/M4AFL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102238182 ^@ http://purl.uniprot.org/uniprot/M4AFR3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102218086 ^@ http://purl.uniprot.org/uniprot/A0A3B5R469 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:paf1 ^@ http://purl.uniprot.org/uniprot/M3ZPP7 ^@ Similarity ^@ Belongs to the PAF1 family. http://togogenome.org/gene/8083:zdhhc23 ^@ http://purl.uniprot.org/uniprot/M4A6L4 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/8083:LOC102228453 ^@ http://purl.uniprot.org/uniprot/A0A3B5REU6 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/8083:exoc3 ^@ http://purl.uniprot.org/uniprot/M3ZFS3 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/8083:mapk8ip2 ^@ http://purl.uniprot.org/uniprot/M3ZR02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JIP scaffold family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102223918 ^@ http://purl.uniprot.org/uniprot/A0A3B5QJ09|||http://purl.uniprot.org/uniprot/M4AAM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:slc41a2 ^@ http://purl.uniprot.org/uniprot/M3ZST1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/8083:LOC102229021 ^@ http://purl.uniprot.org/uniprot/M3ZDS3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:LOC102217118 ^@ http://purl.uniprot.org/uniprot/M4AA51 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:polh ^@ http://purl.uniprot.org/uniprot/M4A823 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC106700132 ^@ http://purl.uniprot.org/uniprot/M3ZF58 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:ccdc47 ^@ http://purl.uniprot.org/uniprot/M4A0S4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC47 family.|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/8083:LOC102230118 ^@ http://purl.uniprot.org/uniprot/A0A3B5QFL5 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/8083:tmem53 ^@ http://purl.uniprot.org/uniprot/A0A3B5PS85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM53 family.|||Membrane|||Nucleus outer membrane http://togogenome.org/gene/8083:LOC102225206 ^@ http://purl.uniprot.org/uniprot/A0A3B5R1H3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:gins2 ^@ http://purl.uniprot.org/uniprot/M3ZLN3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS2/PSF2 family.|||Chromosome|||Component of the GINS complex.|||Nucleus http://togogenome.org/gene/8083:LOC102230580 ^@ http://purl.uniprot.org/uniprot/M4APE7 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8083:LOC102217984 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHT5 ^@ Similarity ^@ Belongs to the proteasome subunit S9 family. http://togogenome.org/gene/8083:pclaf ^@ http://purl.uniprot.org/uniprot/M3ZWV8 ^@ Subcellular Location Annotation ^@ Nucleus|||perinuclear region http://togogenome.org/gene/8083:LOC102226815 ^@ http://purl.uniprot.org/uniprot/A0A3B5PU96 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:ajap1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3U2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:prkcq ^@ http://purl.uniprot.org/uniprot/M3ZL78 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. http://togogenome.org/gene/8083:LOC102223200 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0S7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:gtf2a1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R206 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 1 family.|||Nucleus http://togogenome.org/gene/8083:znf592 ^@ http://purl.uniprot.org/uniprot/M3ZLC2 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/8083:tpm4 ^@ http://purl.uniprot.org/uniprot/A0A3B5R8D8|||http://purl.uniprot.org/uniprot/A0A3B5RE57|||http://purl.uniprot.org/uniprot/M3ZMF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/8083:LOC102228247 ^@ http://purl.uniprot.org/uniprot/M3ZZK1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102230655 ^@ http://purl.uniprot.org/uniprot/M4ANC8 ^@ Cofactor|||Similarity ^@ Belongs to the AspA/AstE family. Aspartoacylase subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/8083:LOC102238385 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q6P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAPT1 family.|||Membrane http://togogenome.org/gene/8083:scara5 ^@ http://purl.uniprot.org/uniprot/M3ZVW8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCARA5 family.|||Cell membrane|||Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways.|||Homotrimer.|||Membrane http://togogenome.org/gene/8083:rpl24 ^@ http://purl.uniprot.org/uniprot/A0A3B5PWW9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/8083:cxxc1 ^@ http://purl.uniprot.org/uniprot/M3ZTW5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:igfbp3 ^@ http://purl.uniprot.org/uniprot/M3ZVV1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:sgk2 ^@ http://purl.uniprot.org/uniprot/M4AXQ9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:galnt12 ^@ http://purl.uniprot.org/uniprot/M3ZKP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:LOC102222713 ^@ http://purl.uniprot.org/uniprot/A0A3B5QC60 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/8083:LOC102226945 ^@ http://purl.uniprot.org/uniprot/A0A3B5R390 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:LOC102226585 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q4Z7 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/8083:LOC102235296 ^@ http://purl.uniprot.org/uniprot/A0A3B5QMS1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Early endosome|||Endosome|||Involved in trafficking and recycling of synaptic vesicles.|||Late endosome|||Membrane|||Recycling endosome|||autophagosome|||synaptic vesicle|||trans-Golgi network http://togogenome.org/gene/8083:tmod4 ^@ http://purl.uniprot.org/uniprot/M4AXN0 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/8083:LOC102220669 ^@ http://purl.uniprot.org/uniprot/M4B036 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/8083:mmaa ^@ http://purl.uniprot.org/uniprot/M4A592 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/8083:lhx4 ^@ http://purl.uniprot.org/uniprot/M4AX15 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102223904 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUJ2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102235242 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUT8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. http://togogenome.org/gene/8083:LOC102217965 ^@ http://purl.uniprot.org/uniprot/M4AHQ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:grwd1 ^@ http://purl.uniprot.org/uniprot/M4ACE2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:atp13a3 ^@ http://purl.uniprot.org/uniprot/M3ZTQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Membrane http://togogenome.org/gene/8083:mcm4 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBC0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/8083:ctgf ^@ http://purl.uniprot.org/uniprot/M3ZXG3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:LOC102237703 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9N1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/8083:arglu1 ^@ http://purl.uniprot.org/uniprot/M3ZYW4 ^@ Similarity ^@ Belongs to the UPF0430 family. http://togogenome.org/gene/8083:pdk4 ^@ http://purl.uniprot.org/uniprot/M3ZES7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/8083:LOC102221962 ^@ http://purl.uniprot.org/uniprot/M4ANQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSG1 family.|||Membrane http://togogenome.org/gene/8083:LOC102220744 ^@ http://purl.uniprot.org/uniprot/A0A3B5R4I9 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/8083:stc2 ^@ http://purl.uniprot.org/uniprot/M4A739 ^@ Function|||Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked.|||Its primary function is the prevention of hypercalcemia. Upon release into the circulation, it lowers calcium transport by the gills, thereby reducing its rate of influx from the environment into the extracellular compartment. STC also stimulates phosphate reabsorption by renal proximal tubules. The consequence of this action is increased levels of plasma phosphate, which combines with excess calcium and promotes its disposal into bone and scales. http://togogenome.org/gene/8083:LOC102228162 ^@ http://purl.uniprot.org/uniprot/M3ZEW8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/8083:LOC102230219 ^@ http://purl.uniprot.org/uniprot/A0A3B5R4V0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:LOC102225064 ^@ http://purl.uniprot.org/uniprot/M3ZZQ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane|||Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. http://togogenome.org/gene/8083:loxl2 ^@ http://purl.uniprot.org/uniprot/M4A7R4 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/8083:best3 ^@ http://purl.uniprot.org/uniprot/M4A7Q3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms chloride channels.|||Membrane http://togogenome.org/gene/8083:c6h5orf22 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZ16 ^@ Similarity ^@ Belongs to the UPF0489 family. http://togogenome.org/gene/8083:LOC102226757 ^@ http://purl.uniprot.org/uniprot/M3ZP63 ^@ Similarity ^@ Belongs to the translokin family. http://togogenome.org/gene/8083:pnpo ^@ http://purl.uniprot.org/uniprot/M4AGZ5 ^@ Function|||Similarity ^@ Belongs to the pyridoxamine 5'-phosphate oxidase family.|||Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). http://togogenome.org/gene/8083:got2 ^@ http://purl.uniprot.org/uniprot/M4A7U7 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/8083:mrpl4 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0T7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/8083:LOC102228975 ^@ http://purl.uniprot.org/uniprot/A0A3B5QKQ4 ^@ Similarity ^@ Belongs to the requiem/DPF family. http://togogenome.org/gene/8083:npnt ^@ http://purl.uniprot.org/uniprot/A0A3B5PXM8 ^@ Caution|||Similarity ^@ Belongs to the nephronectin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:fam163a ^@ http://purl.uniprot.org/uniprot/M3ZJR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/8083:fgf12 ^@ http://purl.uniprot.org/uniprot/M4AK04 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:LOC102228592 ^@ http://purl.uniprot.org/uniprot/M3ZRI4 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/8083:gaa ^@ http://purl.uniprot.org/uniprot/M3ZGN0 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 31 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:polr2l ^@ http://purl.uniprot.org/uniprot/M3ZYI7 ^@ Similarity ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family. http://togogenome.org/gene/8083:LOC102229493 ^@ http://purl.uniprot.org/uniprot/M3ZEH8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102227116 ^@ http://purl.uniprot.org/uniprot/M4AHL6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8083:LOC102228024 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HRG family.|||Endosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/8083:LOC102222150 ^@ http://purl.uniprot.org/uniprot/A0A3B5RFK9 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/8083:snrpg ^@ http://purl.uniprot.org/uniprot/M3ZQ65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/8083:LOC102217550 ^@ http://purl.uniprot.org/uniprot/M4ABC4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/8083:tnfsf13b ^@ http://purl.uniprot.org/uniprot/M4ADQ5 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/8083:gtf2b ^@ http://purl.uniprot.org/uniprot/A0A3B5QCM1 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/8083:slc35e3 ^@ http://purl.uniprot.org/uniprot/M4AS33 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:prpf31 ^@ http://purl.uniprot.org/uniprot/A0A3B5R1I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP31 family.|||Cajal body http://togogenome.org/gene/8083:grn ^@ http://purl.uniprot.org/uniprot/M4AR96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the granulin family.|||Secreted http://togogenome.org/gene/8083:LOC102218643 ^@ http://purl.uniprot.org/uniprot/A0A3B5PXP4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8083:insig2 ^@ http://purl.uniprot.org/uniprot/M3ZL26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/8083:plk4 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q007 ^@ Subcellular Location Annotation ^@ centriole http://togogenome.org/gene/8083:LOC102220118 ^@ http://purl.uniprot.org/uniprot/M3ZD93 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/8083:dctn6 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.|||Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.|||cytoskeleton http://togogenome.org/gene/8083:galnt18 ^@ http://purl.uniprot.org/uniprot/M3ZLH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:nkx2-3 ^@ http://purl.uniprot.org/uniprot/A0A3B5RC58 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102231768 ^@ http://purl.uniprot.org/uniprot/A0A3B5R9E2 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/8083:LOC102236679 ^@ http://purl.uniprot.org/uniprot/M4A797 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the fibulin family.|||Homomultimerizes and interacts with various extracellular matrix components.|||Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/8083:LOC102222055 ^@ http://purl.uniprot.org/uniprot/M4ANR7 ^@ Similarity ^@ Belongs to the vasopressin/oxytocin family. http://togogenome.org/gene/8083:LOC102218790 ^@ http://purl.uniprot.org/uniprot/M4APB1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:fgf11 ^@ http://purl.uniprot.org/uniprot/M4AGV0 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:ggnbp2 ^@ http://purl.uniprot.org/uniprot/M3ZTL2 ^@ Function ^@ May be involved in spermatogenesis. http://togogenome.org/gene/8083:bysl ^@ http://purl.uniprot.org/uniprot/A0A3B5QXB5 ^@ Similarity ^@ Belongs to the bystin family. http://togogenome.org/gene/8083:actc1 ^@ http://purl.uniprot.org/uniprot/M4A595 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/8083:bcl7a ^@ http://purl.uniprot.org/uniprot/M4AXU9 ^@ Similarity ^@ Belongs to the BCL7 family. http://togogenome.org/gene/8083:LOC102229862 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q663 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/8083:alkbh1 ^@ http://purl.uniprot.org/uniprot/M4AMJ7 ^@ Cofactor ^@ Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/8083:LOC102217660 ^@ http://purl.uniprot.org/uniprot/M4ANY8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:lpar1 ^@ http://purl.uniprot.org/uniprot/M3ZV99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cell surface|||Endosome|||Membrane http://togogenome.org/gene/8083:LOC102225016 ^@ http://purl.uniprot.org/uniprot/M4ABV8 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/8083:kcnk3 ^@ http://purl.uniprot.org/uniprot/M4ASJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/8083:LOC102217602 ^@ http://purl.uniprot.org/uniprot/M4A4H5 ^@ Similarity ^@ Belongs to the PMEL/NMB family. http://togogenome.org/gene/8083:ube2i ^@ http://purl.uniprot.org/uniprot/M4AWN2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:ccdc22 ^@ http://purl.uniprot.org/uniprot/M4AED8 ^@ Similarity ^@ Belongs to the CCDC22 family. http://togogenome.org/gene/8083:LOC102220633 ^@ http://purl.uniprot.org/uniprot/M4AGZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:LOC102237869 ^@ http://purl.uniprot.org/uniprot/X5IFX0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102228175 ^@ http://purl.uniprot.org/uniprot/M4AJI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:pmp22 ^@ http://purl.uniprot.org/uniprot/M4AS80 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102223913 ^@ http://purl.uniprot.org/uniprot/M4APD9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/8083:LOC102235845 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGQ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102226018 ^@ http://purl.uniprot.org/uniprot/M4AH85 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit C family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm http://togogenome.org/gene/8083:fa2h ^@ http://purl.uniprot.org/uniprot/A0A3B5PWJ5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sterol desaturase family. SCS7 subfamily.|||Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.|||Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:ppp1r14b ^@ http://purl.uniprot.org/uniprot/A0A3B5QF60 ^@ Similarity ^@ Belongs to the PP1 inhibitor family. http://togogenome.org/gene/8083:LOC102233494 ^@ http://purl.uniprot.org/uniprot/A0A3B5QSX1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8083:LOC102226896 ^@ http://purl.uniprot.org/uniprot/M3ZKZ7 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/8083:LOC102226048 ^@ http://purl.uniprot.org/uniprot/M4AW48 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8083:mccc2 ^@ http://purl.uniprot.org/uniprot/M3ZKX9 ^@ Similarity ^@ Belongs to the AccD/PCCB family. http://togogenome.org/gene/8083:LOC102216918 ^@ http://purl.uniprot.org/uniprot/M4AFW3 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/8083:LOC102226944 ^@ http://purl.uniprot.org/uniprot/M3ZGS9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:mrpl17 ^@ http://purl.uniprot.org/uniprot/M3ZX07 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL17 family. http://togogenome.org/gene/8083:ugdh ^@ http://purl.uniprot.org/uniprot/A0A3B5QUC2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.|||Homohexamer.|||Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. http://togogenome.org/gene/8083:LOC102231164 ^@ http://purl.uniprot.org/uniprot/M4A527 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/8083:ndufs8 ^@ http://purl.uniprot.org/uniprot/M4AN65 ^@ Similarity ^@ Belongs to the complex I 23 kDa subunit family. http://togogenome.org/gene/8083:LOC102217432 ^@ http://purl.uniprot.org/uniprot/A0A3B5QNU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/8083:cfl2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QMI1 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/8083:exoc2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QR72 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SEC5 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||Component of the exocyst complex. http://togogenome.org/gene/8083:LOC102227597 ^@ http://purl.uniprot.org/uniprot/A0A3B5PW20 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/8083:pim3 ^@ http://purl.uniprot.org/uniprot/M3ZQU7 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.|||Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. http://togogenome.org/gene/8083:LOC102220354 ^@ http://purl.uniprot.org/uniprot/M3ZY87 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/8083:LOC102237422 ^@ http://purl.uniprot.org/uniprot/M4A807 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/8083:LOC102218496 ^@ http://purl.uniprot.org/uniprot/A0A3B5R0H7 ^@ Similarity ^@ Belongs to the PPP1R15 family. http://togogenome.org/gene/8083:mtg2 ^@ http://purl.uniprot.org/uniprot/M4ALY1 ^@ Similarity ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. http://togogenome.org/gene/8083:idh3b ^@ http://purl.uniprot.org/uniprot/M3ZIS0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/8083:LOC102230850 ^@ http://purl.uniprot.org/uniprot/M3ZKU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/8083:akr1a1 ^@ http://purl.uniprot.org/uniprot/M4ANN0 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the aldo/keto reductase family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/8083:LOC102220304 ^@ http://purl.uniprot.org/uniprot/M3ZJ13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:gpx8 ^@ http://purl.uniprot.org/uniprot/M3ZKL9 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/8083:LOC102230169 ^@ http://purl.uniprot.org/uniprot/M4ACH7 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:napa ^@ http://purl.uniprot.org/uniprot/A0A3B5Q671 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/8083:LOC102234042 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 6A family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:plpp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QTE8|||http://purl.uniprot.org/uniprot/A0A3B5R869 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/8083:cul4b ^@ http://purl.uniprot.org/uniprot/M4AGR6 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/8083:LOC102223107 ^@ http://purl.uniprot.org/uniprot/M3ZYF2 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/8083:LOC102225267 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAI5 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102225981 ^@ http://purl.uniprot.org/uniprot/M4ACB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:atp5pd ^@ http://purl.uniprot.org/uniprot/M3ZX74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase d subunit family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:kcns2 ^@ http://purl.uniprot.org/uniprot/M4B017 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102238278 ^@ http://purl.uniprot.org/uniprot/M4AM76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/8083:gde1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q7Y9 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/8083:cd79a ^@ http://purl.uniprot.org/uniprot/M3ZX38 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102220109 ^@ http://purl.uniprot.org/uniprot/M3ZGT0 ^@ Function|||Similarity ^@ Belongs to the proline oxidase family.|||Converts proline to delta-1-pyrroline-5-carboxylate. http://togogenome.org/gene/8083:LOC102233219 ^@ http://purl.uniprot.org/uniprot/M4AWW7 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/8083:c11h11orf87 ^@ http://purl.uniprot.org/uniprot/M4AZD7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:slc12a1 ^@ http://purl.uniprot.org/uniprot/M4AQG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/8083:LOC102221939 ^@ http://purl.uniprot.org/uniprot/M4ADX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:LOC102226725 ^@ http://purl.uniprot.org/uniprot/M4A3T5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:narf ^@ http://purl.uniprot.org/uniprot/A0A3B5Q095 ^@ Similarity ^@ Belongs to the NARF family. http://togogenome.org/gene/8083:ccndbp1 ^@ http://purl.uniprot.org/uniprot/M4A7P4 ^@ Similarity ^@ Belongs to the CCNDBP1 family. http://togogenome.org/gene/8083:LOC102227037 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDC9 ^@ Similarity ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. http://togogenome.org/gene/8083:kcnk5 ^@ http://purl.uniprot.org/uniprot/M4AW06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/8083:rpl27a ^@ http://purl.uniprot.org/uniprot/M3ZSJ5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/8083:LOC102232868 ^@ http://purl.uniprot.org/uniprot/M4AG33 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/8083:tfip11 ^@ http://purl.uniprot.org/uniprot/M3ZZA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFP11/STIP family.|||Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events.|||Nucleus http://togogenome.org/gene/8083:s1pr1 ^@ http://purl.uniprot.org/uniprot/M4AZF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:vwc2 ^@ http://purl.uniprot.org/uniprot/M4A0U6 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/8083:tapt1 ^@ http://purl.uniprot.org/uniprot/M4A0F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAPT1 family.|||Membrane http://togogenome.org/gene/8083:coq3 ^@ http://purl.uniprot.org/uniprot/M3ZPI2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Mitochondrion inner membrane|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. http://togogenome.org/gene/8083:LOC102232410 ^@ http://purl.uniprot.org/uniprot/M4AHP0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8083:atg3 ^@ http://purl.uniprot.org/uniprot/M4A5U4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG3 family.|||Cytoplasm http://togogenome.org/gene/8083:miga1 ^@ http://purl.uniprot.org/uniprot/M3ZY70 ^@ Similarity ^@ Belongs to the mitoguardin family. http://togogenome.org/gene/8083:rps12 ^@ http://purl.uniprot.org/uniprot/A0A3B5QT96 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family. http://togogenome.org/gene/8083:LOC102227031 ^@ http://purl.uniprot.org/uniprot/M4ADA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/8083:LOC102230976 ^@ http://purl.uniprot.org/uniprot/A0A3B5RA32 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uricase family.|||Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.|||Peroxisome http://togogenome.org/gene/8083:plxnb2 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8Q8 ^@ Caution|||Similarity ^@ Belongs to the plexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:ddit4l ^@ http://purl.uniprot.org/uniprot/A0A3B5QR26 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/8083:LOC102221624 ^@ http://purl.uniprot.org/uniprot/A0A3B5PP83 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/8083:LOC102233793 ^@ http://purl.uniprot.org/uniprot/M3ZS45 ^@ Similarity|||Subunit ^@ Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.|||Homotetramer. http://togogenome.org/gene/8083:LOC102233512 ^@ http://purl.uniprot.org/uniprot/M4AC78 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/8083:wdr44 ^@ http://purl.uniprot.org/uniprot/M4ADY4 ^@ Subcellular Location Annotation ^@ trans-Golgi network http://togogenome.org/gene/8083:idh3g ^@ http://purl.uniprot.org/uniprot/A0A3B5Q311 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/8083:LOC102224830 ^@ http://purl.uniprot.org/uniprot/M4A3Z1 ^@ Similarity ^@ Belongs to the PPDPF family. http://togogenome.org/gene/8083:rfx3 ^@ http://purl.uniprot.org/uniprot/M3ZS58 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102230330 ^@ http://purl.uniprot.org/uniprot/M4A3G7 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/8083:LOC102237868 ^@ http://purl.uniprot.org/uniprot/M4ATA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/8083:LOC102218377 ^@ http://purl.uniprot.org/uniprot/M4A1J4 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/8083:prmt7 ^@ http://purl.uniprot.org/uniprot/M4ANE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.|||Nucleus|||cytosol http://togogenome.org/gene/8083:nelfcd ^@ http://purl.uniprot.org/uniprot/M3ZMG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NELF-D family.|||Nucleus http://togogenome.org/gene/8083:LOC102225948 ^@ http://purl.uniprot.org/uniprot/M4AN77 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:parn ^@ http://purl.uniprot.org/uniprot/M4AK71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102226664 ^@ http://purl.uniprot.org/uniprot/A0A3B5QKG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/8083:mtr ^@ http://purl.uniprot.org/uniprot/M4AIQ4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin-B12 dependent methionine synthase family.|||Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.|||Cytoplasm|||Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin. http://togogenome.org/gene/8083:tmem45b ^@ http://purl.uniprot.org/uniprot/M4A9Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/8083:pomt2 ^@ http://purl.uniprot.org/uniprot/M4AJB9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/8083:LOC102220912 ^@ http://purl.uniprot.org/uniprot/M4ABE2 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:btg3 ^@ http://purl.uniprot.org/uniprot/M3ZH13 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/8083:mfn2 ^@ http://purl.uniprot.org/uniprot/M3ZR20 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/8083:ccdc130 ^@ http://purl.uniprot.org/uniprot/A0A3B5QK24 ^@ Similarity ^@ Belongs to the CWC16 family. http://togogenome.org/gene/8083:LOC102222956 ^@ http://purl.uniprot.org/uniprot/A0A3B5QS57|||http://purl.uniprot.org/uniprot/M3ZHK9 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/8083:LOC102219185 ^@ http://purl.uniprot.org/uniprot/M4AJS9 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:hdac9 ^@ http://purl.uniprot.org/uniprot/M4AHC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus http://togogenome.org/gene/8083:bcl2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QUY0 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/8083:cacfd1 ^@ http://purl.uniprot.org/uniprot/M3ZUQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel flower family.|||Membrane http://togogenome.org/gene/8083:gramd1c ^@ http://purl.uniprot.org/uniprot/M4A6K9 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102218237 ^@ http://purl.uniprot.org/uniprot/M4A005 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/8083:LOC102225602 ^@ http://purl.uniprot.org/uniprot/A0A3B5QV32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/8083:LOC102237551 ^@ http://purl.uniprot.org/uniprot/M3ZN31 ^@ Similarity ^@ Belongs to the pyridoxine kinase family. http://togogenome.org/gene/8083:LOC102231591 ^@ http://purl.uniprot.org/uniprot/M3ZHY0 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/8083:fto ^@ http://purl.uniprot.org/uniprot/A0A3B5R3T0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fto family.|||Cytoplasm|||Nucleus speckle http://togogenome.org/gene/8083:LOC102226637 ^@ http://purl.uniprot.org/uniprot/M4A754 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102225569 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWW1 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/8083:odc1 ^@ http://purl.uniprot.org/uniprot/M4AVP0 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/8083:clic2 ^@ http://purl.uniprot.org/uniprot/A0A3B5RB84 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/8083:LOC102228039 ^@ http://purl.uniprot.org/uniprot/A0A3B5PZS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102223634 ^@ http://purl.uniprot.org/uniprot/M4A1Z4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102223342 ^@ http://purl.uniprot.org/uniprot/M4AQT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/8083:LOC102225106 ^@ http://purl.uniprot.org/uniprot/A0A3B5QDU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/8083:LOC102219418 ^@ http://purl.uniprot.org/uniprot/M3ZSY8 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/8083:st13 ^@ http://purl.uniprot.org/uniprot/M3ZND3 ^@ Similarity ^@ Belongs to the FAM10 family. http://togogenome.org/gene/8083:antxr2 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATR family.|||Membrane http://togogenome.org/gene/8083:LOC102235798 ^@ http://purl.uniprot.org/uniprot/M4A4R1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:foxk2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PX82 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:pitx2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PRJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/8083:mtmr11 ^@ http://purl.uniprot.org/uniprot/A0A3B5PW95 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/8083:LOC102232895 ^@ http://purl.uniprot.org/uniprot/M4AXA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/8083:bbs10 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q709 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/8083:drc1 ^@ http://purl.uniprot.org/uniprot/M4ALE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC1 family.|||cilium axoneme|||flagellum axoneme http://togogenome.org/gene/8083:LOC102237892 ^@ http://purl.uniprot.org/uniprot/M4AJT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TECPR1 family.|||Lysosome membrane|||autophagosome membrane http://togogenome.org/gene/8083:tubb4b ^@ http://purl.uniprot.org/uniprot/M3ZNZ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/8083:rpl8 ^@ http://purl.uniprot.org/uniprot/M4ATL9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/8083:LOC102233977 ^@ http://purl.uniprot.org/uniprot/M4AP50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/8083:iah1 ^@ http://purl.uniprot.org/uniprot/M4AFM8 ^@ Function|||Similarity ^@ Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.|||Probable lipase. http://togogenome.org/gene/8083:tspan13 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQR4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:idi1 ^@ http://purl.uniprot.org/uniprot/M3ZQV6 ^@ Function|||Similarity ^@ Belongs to the IPP isomerase type 1 family.|||Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/8083:LOC102235968 ^@ http://purl.uniprot.org/uniprot/M3ZV79 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/8083:LOC102233479 ^@ http://purl.uniprot.org/uniprot/M4AX40 ^@ Similarity ^@ Belongs to the DSH family. http://togogenome.org/gene/8083:LOC102223162 ^@ http://purl.uniprot.org/uniprot/M3ZK75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/8083:tinagl1 ^@ http://purl.uniprot.org/uniprot/M3ZLW6 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/8083:erc1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9S0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:LOC102230089 ^@ http://purl.uniprot.org/uniprot/M3ZUP2 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/8083:wls ^@ http://purl.uniprot.org/uniprot/M3ZP78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the wntless family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:LOC102236316 ^@ http://purl.uniprot.org/uniprot/M4A9Y5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/8083:sardh ^@ http://purl.uniprot.org/uniprot/M3ZHE1 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/8083:kcng1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUR1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102224264 ^@ http://purl.uniprot.org/uniprot/M4A511 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/8083:LOC102235556 ^@ http://purl.uniprot.org/uniprot/M3ZRX8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102227531 ^@ http://purl.uniprot.org/uniprot/A0A3B5QFV9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:gpn2 ^@ http://purl.uniprot.org/uniprot/M4A8H1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/8083:pla2g4a ^@ http://purl.uniprot.org/uniprot/M3ZJL6 ^@ Domain ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding. http://togogenome.org/gene/8083:LOC102219217 ^@ http://purl.uniprot.org/uniprot/A0A3B5RE16 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:sept5 ^@ http://purl.uniprot.org/uniprot/M4AJT7 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/8083:nsdhl ^@ http://purl.uniprot.org/uniprot/M4A520 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/8083:uxt ^@ http://purl.uniprot.org/uniprot/M3ZGM5 ^@ Similarity ^@ Belongs to the UXT family. http://togogenome.org/gene/8083:mgme1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R240 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGME1 family.|||Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair.|||Mitochondrion http://togogenome.org/gene/8083:LOC102221492 ^@ http://purl.uniprot.org/uniprot/M4ADT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:thoc7 ^@ http://purl.uniprot.org/uniprot/M3ZIH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC7 family.|||Nucleus|||Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. http://togogenome.org/gene/8083:LOC102228313 ^@ http://purl.uniprot.org/uniprot/M3ZJ12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/8083:LOC102222944 ^@ http://purl.uniprot.org/uniprot/A0A3B5QTU5 ^@ Similarity ^@ Belongs to the vacuolar ATPase subunit S1 family. http://togogenome.org/gene/8083:LOC102221181 ^@ http://purl.uniprot.org/uniprot/M4A448 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/8083:dync1li2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QU89 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.|||Belongs to the dynein light intermediate chain family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).|||cytoskeleton http://togogenome.org/gene/8083:LOC102230533 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVW1|||http://purl.uniprot.org/uniprot/M3ZQX6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/8083:LOC102237393 ^@ http://purl.uniprot.org/uniprot/M4AF09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CART family.|||Secreted http://togogenome.org/gene/8083:sepsecs ^@ http://purl.uniprot.org/uniprot/M4A1Y8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SepSecS family.|||Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.|||Cytoplasm|||Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer. http://togogenome.org/gene/8083:slc25a33 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:LOC102225902 ^@ http://purl.uniprot.org/uniprot/A0A3B5PR89 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the noggin family.|||Homodimer.|||Secreted http://togogenome.org/gene/8083:smarca5 ^@ http://purl.uniprot.org/uniprot/M4A5J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.|||Nucleus http://togogenome.org/gene/8083:LOC102229393 ^@ http://purl.uniprot.org/uniprot/A0A3B5PZT2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:colgalt1 ^@ http://purl.uniprot.org/uniprot/M4ACB2 ^@ Similarity ^@ Belongs to the glycosyltransferase 25 family. http://togogenome.org/gene/8083:slc7a7 ^@ http://purl.uniprot.org/uniprot/M3ZH01 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102226378 ^@ http://purl.uniprot.org/uniprot/M3ZKS6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:rhag ^@ http://purl.uniprot.org/uniprot/M4AT44 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Cell membrane|||Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.|||Membrane http://togogenome.org/gene/8083:mrrf ^@ http://purl.uniprot.org/uniprot/A0A3B5QD91 ^@ Function|||Similarity ^@ Belongs to the RRF family.|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/8083:slc25a24 ^@ http://purl.uniprot.org/uniprot/A0A3B5PV28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102219662 ^@ http://purl.uniprot.org/uniprot/A0A3B5PTY8 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/8083:LOC102232695 ^@ http://purl.uniprot.org/uniprot/M4AWJ9 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/8083:ca7 ^@ http://purl.uniprot.org/uniprot/M4AX81 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/8083:ndufa12 ^@ http://purl.uniprot.org/uniprot/M4A3A3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA12 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:pde2a ^@ http://purl.uniprot.org/uniprot/A0A3B5QRE6 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/8083:ttc9 ^@ http://purl.uniprot.org/uniprot/M4A929 ^@ Similarity ^@ Belongs to the TTC9 family. http://togogenome.org/gene/8083:LOC102236540 ^@ http://purl.uniprot.org/uniprot/A0A3B5QS70 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/8083:zdhhc9 ^@ http://purl.uniprot.org/uniprot/A0A3B5RD56 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/8083:LOC102235822 ^@ http://purl.uniprot.org/uniprot/M3ZJY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FCHO family.|||clathrin-coated pit http://togogenome.org/gene/8083:akap12 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7M3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102218019 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/8083:pde7a ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0P8 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/8083:ggps1 ^@ http://purl.uniprot.org/uniprot/M3ZWH7 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/8083:vapa ^@ http://purl.uniprot.org/uniprot/M3ZF12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:slc30a5 ^@ http://purl.uniprot.org/uniprot/M3ZSA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Functions as a zinc transporter.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/8083:dbt ^@ http://purl.uniprot.org/uniprot/A0A3B5QZ93 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/8083:gsk3b ^@ http://purl.uniprot.org/uniprot/M3ZPB0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/8083:LOC102224227 ^@ http://purl.uniprot.org/uniprot/M3ZGR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/8083:psmc6 ^@ http://purl.uniprot.org/uniprot/M3ZSZ4 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/8083:LOC102233591 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUG6 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/8083:LOC102221826 ^@ http://purl.uniprot.org/uniprot/A0A3B5R862 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:LOC102229429 ^@ http://purl.uniprot.org/uniprot/M4A0Z7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/8083:msh4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QL95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutS family.|||Component of the post-replicative DNA mismatch repair system (MMR).|||Nucleus http://togogenome.org/gene/8083:LOC102225809 ^@ http://purl.uniprot.org/uniprot/A0A3B5R0S3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:LOC102221867 ^@ http://purl.uniprot.org/uniprot/M3ZHB9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:blk ^@ http://purl.uniprot.org/uniprot/M4AEG0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/8083:cmtm6 ^@ http://purl.uniprot.org/uniprot/M3ZF06 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:cdc5l ^@ http://purl.uniprot.org/uniprot/M3ZXV3 ^@ Similarity ^@ Belongs to the CEF1 family. http://togogenome.org/gene/8083:LOC102221486 ^@ http://purl.uniprot.org/uniprot/M4AQH0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:rpl21 ^@ http://purl.uniprot.org/uniprot/A0A3B5PZ45 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/8083:LOC102235677 ^@ http://purl.uniprot.org/uniprot/M4AIZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.|||Belongs to the ATG37 family.|||Membrane http://togogenome.org/gene/8083:LOC102234397 ^@ http://purl.uniprot.org/uniprot/M3ZDD4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic10 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102217859 ^@ http://purl.uniprot.org/uniprot/M3ZJ97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/8083:LOC102237091 ^@ http://purl.uniprot.org/uniprot/A0A3B5QNS3 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/8083:LOC102218792 ^@ http://purl.uniprot.org/uniprot/M3ZKC0 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/8083:LOC102229660 ^@ http://purl.uniprot.org/uniprot/M4A405 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/8083:LOC102234573 ^@ http://purl.uniprot.org/uniprot/M3ZEN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/8083:mppe1 ^@ http://purl.uniprot.org/uniprot/M3ZFE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the metallophosphoesterase superfamily. MPPE1 family.|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.|||cis-Golgi network membrane http://togogenome.org/gene/8083:nek9 ^@ http://purl.uniprot.org/uniprot/M4AK99 ^@ Similarity ^@ Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. http://togogenome.org/gene/8083:hgs ^@ http://purl.uniprot.org/uniprot/M4AEV3 ^@ Subcellular Location Annotation ^@ Early endosome membrane http://togogenome.org/gene/8083:LOC102227451 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCRIP family.|||Nucleus|||Stress granule http://togogenome.org/gene/8083:trmt61a ^@ http://purl.uniprot.org/uniprot/M4AVJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.|||Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.|||Nucleus http://togogenome.org/gene/8083:LOC102229876 ^@ http://purl.uniprot.org/uniprot/M3ZHP8 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/8083:fam102b ^@ http://purl.uniprot.org/uniprot/A0A3B5QA56 ^@ Similarity ^@ Belongs to the EEIG family. http://togogenome.org/gene/8083:LOC102235421 ^@ http://purl.uniprot.org/uniprot/M3ZXB6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Homomer. Forms heteromers with ACKR4.|||Membrane http://togogenome.org/gene/8083:LOC102235906 ^@ http://purl.uniprot.org/uniprot/A0A3B5RCM9 ^@ Similarity ^@ Belongs to the DDA1 family. http://togogenome.org/gene/8083:rtn1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGI2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102228740 ^@ http://purl.uniprot.org/uniprot/M3ZR58 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/8083:gnb5 ^@ http://purl.uniprot.org/uniprot/M3ZX21 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/8083:LOC102220986 ^@ http://purl.uniprot.org/uniprot/A0A3B5QD84 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:syngr1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QC32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/8083:LOC102236464 ^@ http://purl.uniprot.org/uniprot/M4B113 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:LOC102232096 ^@ http://purl.uniprot.org/uniprot/M4A110 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/8083:LOC102222912 ^@ http://purl.uniprot.org/uniprot/A0A3B5QCV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-alpha family. G(12) subfamily.|||Membrane http://togogenome.org/gene/8083:LOC102225449 ^@ http://purl.uniprot.org/uniprot/M4AFZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tumor necrosis factor family.|||Membrane http://togogenome.org/gene/8083:LOC102227411 ^@ http://purl.uniprot.org/uniprot/M4AAN1 ^@ Function|||Similarity ^@ Belongs to the PET191 family.|||Involved in an early step of the mitochondrial complex IV assembly process. http://togogenome.org/gene/8083:clic1 ^@ http://purl.uniprot.org/uniprot/M4AIA1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/8083:arrdc2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PXA0 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/8083:LOC102236068 ^@ http://purl.uniprot.org/uniprot/A0A3B5RE82|||http://purl.uniprot.org/uniprot/M4A6B5 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/8083:LOC102235571 ^@ http://purl.uniprot.org/uniprot/A0A3B5QSD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/8083:c8h18orf32 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHG1 ^@ Similarity ^@ Belongs to the UPF0729 family. http://togogenome.org/gene/8083:LOC102226226 ^@ http://purl.uniprot.org/uniprot/M3ZPR8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/8083:LOC102219479 ^@ http://purl.uniprot.org/uniprot/M4A2J9 ^@ Cofactor|||Function ^@ Binds 1 Ca(2+) ion per subunit.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/8083:LOC102227665 ^@ http://purl.uniprot.org/uniprot/M4AUG2 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:psmc3 ^@ http://purl.uniprot.org/uniprot/M4AKH5 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/8083:ugcg ^@ http://purl.uniprot.org/uniprot/M3ZS64 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/8083:LOC102229515 ^@ http://purl.uniprot.org/uniprot/A0A3B5RCA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:kif3a ^@ http://purl.uniprot.org/uniprot/M4A3Y4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/8083:ctu1 ^@ http://purl.uniprot.org/uniprot/M3ZL36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. http://togogenome.org/gene/8083:LOC106699750 ^@ http://purl.uniprot.org/uniprot/A0A3B5R1F4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/8083:hdhd2 ^@ http://purl.uniprot.org/uniprot/M3ZJ19 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/8083:slc5a3 ^@ http://purl.uniprot.org/uniprot/M4AYS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/8083:snx6 ^@ http://purl.uniprot.org/uniprot/M3ZRQ9 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/8083:LOC102231475 ^@ http://purl.uniprot.org/uniprot/M4A209 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/8083:tmem234 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM234 family.|||Membrane http://togogenome.org/gene/8083:LOC102227732 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBB8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:rpl29 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZT5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL29 family. http://togogenome.org/gene/8083:spsb4 ^@ http://purl.uniprot.org/uniprot/M4A1N8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102238127 ^@ http://purl.uniprot.org/uniprot/A0A3B5QSH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/8083:cdr2l ^@ http://purl.uniprot.org/uniprot/A0A3B5QEC2 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/8083:nol6 ^@ http://purl.uniprot.org/uniprot/M4AYB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAP family.|||Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.|||nucleolus http://togogenome.org/gene/8083:LOC102234970 ^@ http://purl.uniprot.org/uniprot/M3ZWY9 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/8083:ranbp9 ^@ http://purl.uniprot.org/uniprot/M3ZX51 ^@ Similarity ^@ Belongs to the RANBP9/10 family. http://togogenome.org/gene/8083:tfap2d ^@ http://purl.uniprot.org/uniprot/A0A3B5QM02 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/8083:mocos ^@ http://purl.uniprot.org/uniprot/M4A0Q0 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.|||Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. http://togogenome.org/gene/8083:LOC102235967 ^@ http://purl.uniprot.org/uniprot/M4AL69 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family.|||Homotrimer.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/8083:LOC102231286 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQ63 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/8083:pusl1 ^@ http://purl.uniprot.org/uniprot/M4AWN4 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/8083:LOC102221568 ^@ http://purl.uniprot.org/uniprot/M3ZMF2 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.|||Nucleus http://togogenome.org/gene/8083:dnttip2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QN73 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/8083:srm ^@ http://purl.uniprot.org/uniprot/M4AA05 ^@ Similarity ^@ Belongs to the spermidine/spermine synthase family. http://togogenome.org/gene/8083:mcts1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QC20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCTS1 family.|||Cytoplasm http://togogenome.org/gene/8083:lipt2 ^@ http://purl.uniprot.org/uniprot/M4AF21 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LipB family.|||Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.|||Mitochondrion http://togogenome.org/gene/8083:mrto4 ^@ http://purl.uniprot.org/uniprot/M4AS99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the pre-60S ribosomal particle.|||Belongs to the universal ribosomal protein uL10 family.|||Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.|||Cytoplasm|||nucleolus http://togogenome.org/gene/8083:b3gnt9 ^@ http://purl.uniprot.org/uniprot/M3ZUX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:LOC102236729 ^@ http://purl.uniprot.org/uniprot/M3ZVR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:zbed4 ^@ http://purl.uniprot.org/uniprot/M4AYT2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:sfrp5 ^@ http://purl.uniprot.org/uniprot/M3ZK96 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102229279 ^@ http://purl.uniprot.org/uniprot/A0A3B5R133 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/8083:LOC102229123 ^@ http://purl.uniprot.org/uniprot/M4A7X6 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/8083:cpne7 ^@ http://purl.uniprot.org/uniprot/A0A3B5QHM5 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/8083:fam198b ^@ http://purl.uniprot.org/uniprot/M3ZJ07 ^@ Similarity ^@ Belongs to the GASK family. http://togogenome.org/gene/8083:chmp3 ^@ http://purl.uniprot.org/uniprot/A0A3B5PX05 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/8083:LOC102229539 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q5V7 ^@ Similarity ^@ Belongs to the CNOT2/3/5 family. http://togogenome.org/gene/8083:LOC102233956 ^@ http://purl.uniprot.org/uniprot/M4AK79 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/8083:ispd ^@ http://purl.uniprot.org/uniprot/M4AX61 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.|||Homodimer.|||cytosol http://togogenome.org/gene/8083:LOC102230574 ^@ http://purl.uniprot.org/uniprot/M4A6H9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Membrane http://togogenome.org/gene/8083:gab2 ^@ http://purl.uniprot.org/uniprot/M4AM14 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/8083:LOC102234901 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/8083:ubl3 ^@ http://purl.uniprot.org/uniprot/M4A1S5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102237891 ^@ http://purl.uniprot.org/uniprot/A0A3B5RE37 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:ephb4 ^@ http://purl.uniprot.org/uniprot/A0A3B5PXH3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102232675 ^@ http://purl.uniprot.org/uniprot/M4AHP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8083:ccm2l ^@ http://purl.uniprot.org/uniprot/M4A4G7 ^@ Similarity ^@ Belongs to the CCM2 family. http://togogenome.org/gene/8083:LOC102230245 ^@ http://purl.uniprot.org/uniprot/M4AD37 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:atp6v0d1 ^@ http://purl.uniprot.org/uniprot/M4AWI0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/8083:LOC102219372 ^@ http://purl.uniprot.org/uniprot/A0A3B5QXZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM205 family.|||Membrane http://togogenome.org/gene/8083:ap1b1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3P7 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/8083:LOC102225231 ^@ http://purl.uniprot.org/uniprot/M3ZST2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:supt16h ^@ http://purl.uniprot.org/uniprot/M3ZG51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24 family. SPT16 subfamily.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Component of the FACT complex.|||Nucleus http://togogenome.org/gene/8083:LOC102231296 ^@ http://purl.uniprot.org/uniprot/M4AL16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/8083:nfyb ^@ http://purl.uniprot.org/uniprot/A0A3B5QHW0 ^@ Function|||Similarity ^@ Belongs to the NFYB/HAP3 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. http://togogenome.org/gene/8083:LOC102235759 ^@ http://purl.uniprot.org/uniprot/M3ZZ61 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/8083:LOC102220528 ^@ http://purl.uniprot.org/uniprot/M3ZNC4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/8083:LOC102233588 ^@ http://purl.uniprot.org/uniprot/M4AFM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/8083:LOC102220860 ^@ http://purl.uniprot.org/uniprot/M3ZZZ1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase inhibitor family.|||Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.|||Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.|||Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.|||Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.|||Mitochondrion http://togogenome.org/gene/8083:LOC102222954 ^@ http://purl.uniprot.org/uniprot/M3ZYA0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102234380 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3U9 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of AMPK and MAPK1/2 signaling pathways.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/8083:grk1 ^@ http://purl.uniprot.org/uniprot/M4AXX2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/8083:tfdp1 ^@ http://purl.uniprot.org/uniprot/M4AB58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/8083:LOC102217423 ^@ http://purl.uniprot.org/uniprot/M4AGB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102218128 ^@ http://purl.uniprot.org/uniprot/M4AG92 ^@ Similarity ^@ Belongs to the RENT3 family. http://togogenome.org/gene/8083:haus1 ^@ http://purl.uniprot.org/uniprot/M4AT28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS1 family.|||spindle http://togogenome.org/gene/8083:trim9 ^@ http://purl.uniprot.org/uniprot/M4AKG5 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/8083:rmnd1 ^@ http://purl.uniprot.org/uniprot/M4ALR7 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/8083:LOC102228145 ^@ http://purl.uniprot.org/uniprot/M3ZNJ2 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/8083:LOC102236331 ^@ http://purl.uniprot.org/uniprot/M4ABR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:fgf1 ^@ http://purl.uniprot.org/uniprot/M3ZH55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Cytoplasm|||Nucleus|||Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.|||Secreted|||cell cortex|||cytosol http://togogenome.org/gene/8083:lin7a ^@ http://purl.uniprot.org/uniprot/A0A3B5QQH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-7 family.|||Cell junction|||Cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. http://togogenome.org/gene/8083:LOC102220922 ^@ http://purl.uniprot.org/uniprot/M4A422 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/8083:LOC102218507 ^@ http://purl.uniprot.org/uniprot/M4A735 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/8083:wdfy2 ^@ http://purl.uniprot.org/uniprot/M3ZFT0 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/8083:LOC102232683 ^@ http://purl.uniprot.org/uniprot/M4A235 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BRE1 family.|||Nucleus http://togogenome.org/gene/8083:LOC102219207 ^@ http://purl.uniprot.org/uniprot/M4APC8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/8083:LOC102217794 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPI7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDH/MDH superfamily. LDH family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/8083:hscb ^@ http://purl.uniprot.org/uniprot/A0A3B5QZ25 ^@ Similarity ^@ Belongs to the HscB family. http://togogenome.org/gene/8083:yod1 ^@ http://purl.uniprot.org/uniprot/M4ATH0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin. http://togogenome.org/gene/8083:fat3 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPN4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102226844 ^@ http://purl.uniprot.org/uniprot/M4AXM1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102231851 ^@ http://purl.uniprot.org/uniprot/A0A3B5QJH4|||http://purl.uniprot.org/uniprot/M3ZYC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/8083:atp1b4 ^@ http://purl.uniprot.org/uniprot/A0A3B5QMP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/8083:LOC102225275 ^@ http://purl.uniprot.org/uniprot/M3ZFP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/8083:snx33 ^@ http://purl.uniprot.org/uniprot/M3ZYM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/8083:LOC102229718 ^@ http://purl.uniprot.org/uniprot/A0A3B5QAW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/8083:LOC102222104 ^@ http://purl.uniprot.org/uniprot/A0A3B5QKW1 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/8083:gng7 ^@ http://purl.uniprot.org/uniprot/M3ZKF3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/8083:LOC102221504 ^@ http://purl.uniprot.org/uniprot/M4AU55 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/8083:gatad1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QYJ5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:tmem170a ^@ http://purl.uniprot.org/uniprot/A0A3B5QAK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/8083:chac2 ^@ http://purl.uniprot.org/uniprot/M4ANZ3 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/8083:cpeb4 ^@ http://purl.uniprot.org/uniprot/M3ZDK5 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/8083:vma21 ^@ http://purl.uniprot.org/uniprot/M4A5A9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VMA21 family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. http://togogenome.org/gene/8083:bcas2 ^@ http://purl.uniprot.org/uniprot/M4ADV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPF27 family.|||Nucleus http://togogenome.org/gene/8083:glmp ^@ http://purl.uniprot.org/uniprot/M4AT41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GLMP family.|||Lysosome membrane|||Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization. http://togogenome.org/gene/8083:LOC102218946 ^@ http://purl.uniprot.org/uniprot/M4APC5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102217518 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZH5|||http://purl.uniprot.org/uniprot/M4ATJ5 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/8083:bsx ^@ http://purl.uniprot.org/uniprot/M3ZH93 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:ano6 ^@ http://purl.uniprot.org/uniprot/M3ZPA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:dpy19l1 ^@ http://purl.uniprot.org/uniprot/M4AXA6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/8083:vps4b ^@ http://purl.uniprot.org/uniprot/M4APY7 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/8083:lamb1 ^@ http://purl.uniprot.org/uniprot/M4AP48 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/8083:amt ^@ http://purl.uniprot.org/uniprot/M4AY23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvT family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/8083:LOC102229331 ^@ http://purl.uniprot.org/uniprot/M4A7F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/8083:LOC102233845 ^@ http://purl.uniprot.org/uniprot/M4AMI5 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/8083:LOC102219770 ^@ http://purl.uniprot.org/uniprot/A0A3B5R5I7|||http://purl.uniprot.org/uniprot/M4AW60 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.|||Nucleus http://togogenome.org/gene/8083:LOC102237883 ^@ http://purl.uniprot.org/uniprot/M4AC08 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/8083:serpine3 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0A4 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8083:mrpl9 ^@ http://purl.uniprot.org/uniprot/A0A3B5QBN5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family. http://togogenome.org/gene/8083:LOC102223115 ^@ http://purl.uniprot.org/uniprot/M4ASQ4 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/8083:gusb ^@ http://purl.uniprot.org/uniprot/M4AUX7 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 2 family.|||Homotetramer.|||Inhibited by L-aspartic acid.|||Lysosome|||Plays an important role in the degradation of dermatan and keratan sulfates. http://togogenome.org/gene/8083:LOC102229335 ^@ http://purl.uniprot.org/uniprot/M4AUH0 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/8083:LOC102220112 ^@ http://purl.uniprot.org/uniprot/A0A3B5R1Q9 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/8083:rtn3 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7K1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:vkorc1l1 ^@ http://purl.uniprot.org/uniprot/M4AUW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VKOR family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102229201 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBH5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/8083:LOC102219984 ^@ http://purl.uniprot.org/uniprot/M4AJQ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102222483 ^@ http://purl.uniprot.org/uniprot/M3ZSN1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:LOC102222094 ^@ http://purl.uniprot.org/uniprot/M4A332 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/8083:rnaseh1 ^@ http://purl.uniprot.org/uniprot/M3ZJG9 ^@ Function|||Similarity ^@ Belongs to the RNase H family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. http://togogenome.org/gene/8083:taf13 ^@ http://purl.uniprot.org/uniprot/M4AYV9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:plppr1 ^@ http://purl.uniprot.org/uniprot/M3ZJ52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/8083:LOC102220696 ^@ http://purl.uniprot.org/uniprot/M4AT70 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fibulin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/8083:LOC102228921 ^@ http://purl.uniprot.org/uniprot/A0A3B5PWT6 ^@ Similarity ^@ Belongs to the synuclein family. http://togogenome.org/gene/8083:pign ^@ http://purl.uniprot.org/uniprot/M3ZEJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.|||Endoplasmic reticulum membrane|||Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.|||Membrane http://togogenome.org/gene/8083:mfsd6l ^@ http://purl.uniprot.org/uniprot/M4B108 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. MFSD6 family.|||Membrane http://togogenome.org/gene/8083:LOC102230155 ^@ http://purl.uniprot.org/uniprot/M4AH70 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:LOC102231626 ^@ http://purl.uniprot.org/uniprot/M3ZGM9 ^@ Similarity ^@ Belongs to the vacuolar ATPase subunit S1 family. http://togogenome.org/gene/8083:LOC102225493 ^@ http://purl.uniprot.org/uniprot/M4AI49 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/8083:cmklr1 ^@ http://purl.uniprot.org/uniprot/M4B0Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/8083:LOC102221682 ^@ http://purl.uniprot.org/uniprot/A0A3B5QCU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102237275 ^@ http://purl.uniprot.org/uniprot/A0A3B5QPP9 ^@ Similarity ^@ Belongs to the G-alpha family. G(s) subfamily. http://togogenome.org/gene/8083:LOC102235567 ^@ http://purl.uniprot.org/uniprot/A0A3B5QM23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:pofut1 ^@ http://purl.uniprot.org/uniprot/M3ZPZ1 ^@ Similarity ^@ Belongs to the glycosyltransferase 65 family. http://togogenome.org/gene/8083:tmem244 ^@ http://purl.uniprot.org/uniprot/M3ZXR8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:pelp1 ^@ http://purl.uniprot.org/uniprot/M4A137 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RIX1/PELP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:trub1 ^@ http://purl.uniprot.org/uniprot/M4AJT0 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/8083:cwc15 ^@ http://purl.uniprot.org/uniprot/M4AAK8 ^@ Similarity ^@ Belongs to the CWC15 family. http://togogenome.org/gene/8083:LOC102228081 ^@ http://purl.uniprot.org/uniprot/M3ZRE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||cytoskeleton http://togogenome.org/gene/8083:LOC102227811 ^@ http://purl.uniprot.org/uniprot/A0A3B5QIE3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:eaf1 ^@ http://purl.uniprot.org/uniprot/M4AFT9 ^@ Similarity ^@ Belongs to the EAF family. http://togogenome.org/gene/8083:LOC102217393 ^@ http://purl.uniprot.org/uniprot/M3ZRY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/8083:LOC102228793 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8R1 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/8083:gadd45gip1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R4H6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.|||Belongs to the mitochondrion-specific ribosomal protein mL64 family.|||Mitochondrion|||Nucleus http://togogenome.org/gene/8083:cyhr1 ^@ http://purl.uniprot.org/uniprot/M3ZLA5 ^@ Similarity ^@ Belongs to the ZFTRAF1 family. http://togogenome.org/gene/8083:hspb8 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDH0 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/8083:LOC102221304 ^@ http://purl.uniprot.org/uniprot/M3ZPZ3 ^@ Similarity ^@ Belongs to the LCA5 family. http://togogenome.org/gene/8083:capzb ^@ http://purl.uniprot.org/uniprot/A0A3B5QAE8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the F-actin-capping protein beta subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit.|||cytoskeleton http://togogenome.org/gene/8083:actr10 ^@ http://purl.uniprot.org/uniprot/M4A1S9 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/8083:ppil4 ^@ http://purl.uniprot.org/uniprot/M3ZS30 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/8083:cdk20 ^@ http://purl.uniprot.org/uniprot/M3ZGP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||cilium http://togogenome.org/gene/8083:LOC102236513 ^@ http://purl.uniprot.org/uniprot/A0A3B5R8W4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||Vacuole membrane|||clathrin-coated vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/8083:yipf5 ^@ http://purl.uniprot.org/uniprot/M3ZH17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/8083:mrpl53 ^@ http://purl.uniprot.org/uniprot/A0A3B5QEM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL53 family.|||Mitochondrion http://togogenome.org/gene/8083:LOC102219703 ^@ http://purl.uniprot.org/uniprot/A0A3B5PYG3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/8083:btc ^@ http://purl.uniprot.org/uniprot/D1MGM0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102237376 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q5B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/8083:cadm3 ^@ http://purl.uniprot.org/uniprot/M3ZU07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nectin family.|||Membrane http://togogenome.org/gene/8083:ilvbl ^@ http://purl.uniprot.org/uniprot/M3ZGN8 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/8083:vamp3 ^@ http://purl.uniprot.org/uniprot/M3ZP18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/8083:atp13a1 ^@ http://purl.uniprot.org/uniprot/M4AG25 ^@ Similarity ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. http://togogenome.org/gene/8083:fam46b ^@ http://purl.uniprot.org/uniprot/M4A8B7 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/8083:LOC102237801 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q579 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rabaptin family.|||Cytoplasm|||Early endosome|||Endosome http://togogenome.org/gene/8083:syf2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PSY7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYF2 family.|||Involved in pre-mRNA splicing.|||May be part of a spliceosome complex.|||Nucleus http://togogenome.org/gene/8083:bmp15 ^@ http://purl.uniprot.org/uniprot/A0A3B5QF47 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/8083:LOC102228904 ^@ http://purl.uniprot.org/uniprot/M4AFL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AMY1 family.|||Nucleus http://togogenome.org/gene/8083:pan3 ^@ http://purl.uniprot.org/uniprot/M4A5V1 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. PAN3 family.|||Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.|||Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate specificity of the enzyme complex. Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6C.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||P-body|||Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.|||The N-terminal zinc finger binds to poly(A) RNA.|||The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2. http://togogenome.org/gene/8083:cct4 ^@ http://purl.uniprot.org/uniprot/A0A3B5R0J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/8083:smg5 ^@ http://purl.uniprot.org/uniprot/M4AGF3 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays a role in nonsense-mediated mRNA decay. http://togogenome.org/gene/8083:LOC102237838 ^@ http://purl.uniprot.org/uniprot/M4ARN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/8083:tmem97 ^@ http://purl.uniprot.org/uniprot/M4A4U6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM97/sigma-2 receptor family.|||Endoplasmic reticulum membrane|||Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.|||Membrane|||Nucleus membrane|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/8083:fam126a ^@ http://purl.uniprot.org/uniprot/M3ZRP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/8083:fam212b ^@ http://purl.uniprot.org/uniprot/A0A3B5QQA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INKA family.|||Nucleus http://togogenome.org/gene/8083:LOC102217384 ^@ http://purl.uniprot.org/uniprot/M4AWQ0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/8083:ftsj3 ^@ http://purl.uniprot.org/uniprot/M4AUP5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.|||Interacts with NIP7.|||Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.|||nucleolus http://togogenome.org/gene/8083:sh2b3 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q741 ^@ Similarity ^@ Belongs to the SH2B adapter family. http://togogenome.org/gene/8083:vasn ^@ http://purl.uniprot.org/uniprot/M4AZZ8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:tada1 ^@ http://purl.uniprot.org/uniprot/M4AV59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TADA1 family.|||Nucleus|||Probably involved in transcriptional regulation. http://togogenome.org/gene/8083:LOC102218962 ^@ http://purl.uniprot.org/uniprot/M4AGK2 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:hoxd3 ^@ http://purl.uniprot.org/uniprot/M3ZDY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/8083:fam76b ^@ http://purl.uniprot.org/uniprot/M4AAI4 ^@ Similarity ^@ Belongs to the FAM76 family. http://togogenome.org/gene/8083:LOC102217142 ^@ http://purl.uniprot.org/uniprot/M4AZU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102217912 ^@ http://purl.uniprot.org/uniprot/A0A3B5QNS5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:themis2 ^@ http://purl.uniprot.org/uniprot/A0A3B5PPR7 ^@ Similarity ^@ Belongs to the themis family. http://togogenome.org/gene/8083:LOC102220745 ^@ http://purl.uniprot.org/uniprot/M4AZI0 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/8083:LOC102230373 ^@ http://purl.uniprot.org/uniprot/A0A3B5QXY7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:dram1 ^@ http://purl.uniprot.org/uniprot/M3ZGW3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:rnf43 ^@ http://purl.uniprot.org/uniprot/M3ZTU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZNRF3 family.|||Cell membrane http://togogenome.org/gene/8083:kcnj3 ^@ http://purl.uniprot.org/uniprot/M4AA02 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.|||Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.|||Membrane|||This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. http://togogenome.org/gene/8083:galm ^@ http://purl.uniprot.org/uniprot/M4AK23 ^@ Function|||Similarity|||Subunit ^@ Belongs to the aldose epimerase family.|||Monomer.|||Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. http://togogenome.org/gene/8083:LOC102219375 ^@ http://purl.uniprot.org/uniprot/M3ZXJ6 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/8083:stac3 ^@ http://purl.uniprot.org/uniprot/M4AX71 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/8083:gata4 ^@ http://purl.uniprot.org/uniprot/M4A464 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102237217 ^@ http://purl.uniprot.org/uniprot/M4APA8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/8083:hck ^@ http://purl.uniprot.org/uniprot/M3ZPT8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/8083:nop10 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q7F2 ^@ Similarity ^@ Belongs to the NOP10 family. http://togogenome.org/gene/8083:zcchc4 ^@ http://purl.uniprot.org/uniprot/M4AXT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZCCHC4 family.|||Cytoplasm|||nucleolus http://togogenome.org/gene/8083:LOC102218636 ^@ http://purl.uniprot.org/uniprot/M4A956 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/8083:p2ry1 ^@ http://purl.uniprot.org/uniprot/M4B0S6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:tgfb3 ^@ http://purl.uniprot.org/uniprot/M4AJV7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.|||extracellular matrix http://togogenome.org/gene/8083:chd1l ^@ http://purl.uniprot.org/uniprot/A0A3B5RAT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/8083:psmd2 ^@ http://purl.uniprot.org/uniprot/M4A169 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S2 family.|||Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/8083:LOC102222746 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVE6 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/8083:dctn5 ^@ http://purl.uniprot.org/uniprot/M3ZHI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.|||cytoskeleton http://togogenome.org/gene/8083:rpl35a ^@ http://purl.uniprot.org/uniprot/M4AI06 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/8083:LOC102228294 ^@ http://purl.uniprot.org/uniprot/M3ZPE8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:fuca1 ^@ http://purl.uniprot.org/uniprot/M4A120 ^@ Function|||Similarity|||Subunit ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family.|||Homotetramer. http://togogenome.org/gene/8083:LOC102218503 ^@ http://purl.uniprot.org/uniprot/M3ZDJ2 ^@ Similarity ^@ Belongs to the vacuolar ATPase subunit S1 family. http://togogenome.org/gene/8083:LOC102237830 ^@ http://purl.uniprot.org/uniprot/M3ZDM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/8083:LOC102233929 ^@ http://purl.uniprot.org/uniprot/M3ZE27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:nkx2-1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QJ73 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102222603 ^@ http://purl.uniprot.org/uniprot/M4AB72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMR1 family.|||Cytoplasmic ribonucleoprotein granule http://togogenome.org/gene/8083:LOC102233204 ^@ http://purl.uniprot.org/uniprot/A0A3B5QIX4 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/8083:LOC102237081 ^@ http://purl.uniprot.org/uniprot/M4AZG8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102234273 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAZ3 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. http://togogenome.org/gene/8083:usp44 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q9U7 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/8083:LOC102216727 ^@ http://purl.uniprot.org/uniprot/A0A3B5QP22 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102234578 ^@ http://purl.uniprot.org/uniprot/A0A3B5PQH9 ^@ Function|||Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition. http://togogenome.org/gene/8083:miga2 ^@ http://purl.uniprot.org/uniprot/M3ZU69 ^@ Similarity ^@ Belongs to the mitoguardin family. http://togogenome.org/gene/8083:LOC102216777 ^@ http://purl.uniprot.org/uniprot/M4ATE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/8083:ogfrl1 ^@ http://purl.uniprot.org/uniprot/M3ZYL1 ^@ Similarity ^@ Belongs to the opioid growth factor receptor family. http://togogenome.org/gene/8083:LOC102217638 ^@ http://purl.uniprot.org/uniprot/A0A3B5PRU6 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:LOC102221296 ^@ http://purl.uniprot.org/uniprot/M4ABS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/8083:LOC102238150 ^@ http://purl.uniprot.org/uniprot/M4AYG0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102219520 ^@ http://purl.uniprot.org/uniprot/M3ZL71 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/8083:LOC102233699 ^@ http://purl.uniprot.org/uniprot/M4AJP7 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/8083:ube2n ^@ http://purl.uniprot.org/uniprot/M3ZGS3 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/8083:ing5 ^@ http://purl.uniprot.org/uniprot/M4AA17 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/8083:acp7 ^@ http://purl.uniprot.org/uniprot/M4AIJ9 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family. http://togogenome.org/gene/8083:gabarapl2 ^@ http://purl.uniprot.org/uniprot/M4ANN6 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/8083:spopl ^@ http://purl.uniprot.org/uniprot/M4AAZ5 ^@ Similarity ^@ Belongs to the Tdpoz family. http://togogenome.org/gene/8083:aes ^@ http://purl.uniprot.org/uniprot/M4AG51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/8083:LOC102218522 ^@ http://purl.uniprot.org/uniprot/A0A3B5QBB6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:pkig ^@ http://purl.uniprot.org/uniprot/M3ZG90 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/8083:LOC102231012 ^@ http://purl.uniprot.org/uniprot/M3ZVE5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family.|||Homotrimer.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/8083:LOC102228101 ^@ http://purl.uniprot.org/uniprot/M4AXK3 ^@ Similarity ^@ Belongs to the glutaminyl-peptide cyclotransferase family. http://togogenome.org/gene/8083:LOC102222182 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q7N3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102226795 ^@ http://purl.uniprot.org/uniprot/A0A3B5R805 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:cxcr5 ^@ http://purl.uniprot.org/uniprot/A0A3B5QLA9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:gpr156 ^@ http://purl.uniprot.org/uniprot/M3ZPB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:cd99l2 ^@ http://purl.uniprot.org/uniprot/M4ABC5 ^@ Similarity ^@ Belongs to the CD99 family. http://togogenome.org/gene/8083:ltn1 ^@ http://purl.uniprot.org/uniprot/M4A810 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LTN1 family.|||Component of the ribosome quality control complex (RQC).|||E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.|||cytosol http://togogenome.org/gene/8083:LOC102231678 ^@ http://purl.uniprot.org/uniprot/A0A3B5QTA1 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/8083:gucy1a2 ^@ http://purl.uniprot.org/uniprot/M4AUF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102217183 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/8083:bmp2 ^@ http://purl.uniprot.org/uniprot/M4A285 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/8083:dgkz ^@ http://purl.uniprot.org/uniprot/A0A3B5QA74|||http://purl.uniprot.org/uniprot/M3ZXD1 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/8083:LOC102223061 ^@ http://purl.uniprot.org/uniprot/M4ADA3 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/8083:nudt2 ^@ http://purl.uniprot.org/uniprot/M3ZMI0 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/8083:LOC102218645 ^@ http://purl.uniprot.org/uniprot/M4AKU8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:tat ^@ http://purl.uniprot.org/uniprot/M4A3N9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. http://togogenome.org/gene/8083:tcta ^@ http://purl.uniprot.org/uniprot/M4ARA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCTA family.|||Membrane http://togogenome.org/gene/8083:LOC102221546 ^@ http://purl.uniprot.org/uniprot/M4AQ89 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/8083:LOC102230832 ^@ http://purl.uniprot.org/uniprot/A0A3B5QCA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:gtf2ird1 ^@ http://purl.uniprot.org/uniprot/M4ALK5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102224233 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q947 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Membrane http://togogenome.org/gene/8083:LOC102234351 ^@ http://purl.uniprot.org/uniprot/A0A3B5R8G0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102226986 ^@ http://purl.uniprot.org/uniprot/M4AY59 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/8083:ddc ^@ http://purl.uniprot.org/uniprot/M3ZEY7 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/8083:LOC102230636 ^@ http://purl.uniprot.org/uniprot/M4A1X5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/8083:lfng ^@ http://purl.uniprot.org/uniprot/A0A3B5Q4I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:rdh13 ^@ http://purl.uniprot.org/uniprot/M4AX77 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8083:LOC102237510 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calsyntenin family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Postsynaptic cell membrane http://togogenome.org/gene/8083:sys1 ^@ http://purl.uniprot.org/uniprot/M3ZN27 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYS1 family.|||Golgi apparatus membrane|||Interacts with ARFRP1.|||Involved in protein trafficking. May serve as a receptor for ARFRP1.|||Membrane http://togogenome.org/gene/8083:LOC102229016 ^@ http://purl.uniprot.org/uniprot/M3ZKV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/8083:LOC102229404 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7I1 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/8083:LOC102226523 ^@ http://purl.uniprot.org/uniprot/M3ZXX8 ^@ Similarity ^@ Belongs to the proteasome subunit S5A family. http://togogenome.org/gene/8083:LOC102232612 ^@ http://purl.uniprot.org/uniprot/A0A3B5RAC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/8083:shkbp1 ^@ http://purl.uniprot.org/uniprot/M4AKN8 ^@ Similarity ^@ Belongs to the KCTD3 family. http://togogenome.org/gene/8083:insig1 ^@ http://purl.uniprot.org/uniprot/M3ZJW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/8083:LOC102219244 ^@ http://purl.uniprot.org/uniprot/M4A707 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102221191 ^@ http://purl.uniprot.org/uniprot/A0A3B5R734 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:mettl14 ^@ http://purl.uniprot.org/uniprot/M4ATV3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MT-A70-like family.|||Heterodimer; heterodimerizes with mettl3 to form an antiparallel heterodimer that constitutes an active methyltransferase.|||Nucleus|||The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with mettl3, mettl14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. http://togogenome.org/gene/8083:bmp10 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q4W3 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/8083:LOC102225607 ^@ http://purl.uniprot.org/uniprot/M3ZKN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/8083:ypel5 ^@ http://purl.uniprot.org/uniprot/M4A5G7 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/8083:LOC102227686 ^@ http://purl.uniprot.org/uniprot/M4AYR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8083:lars ^@ http://purl.uniprot.org/uniprot/M3ZGZ9 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/8083:rras2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGY0 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/8083:LOC102235634 ^@ http://purl.uniprot.org/uniprot/A0A3B5QC14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/8083:nfe2l2 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q7T0 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/8083:LOC102229893 ^@ http://purl.uniprot.org/uniprot/A0A3B5QP54 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:fgg ^@ http://purl.uniprot.org/uniprot/M4AX00 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/8083:noc4l ^@ http://purl.uniprot.org/uniprot/M3ZFI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF/MAK21 family.|||Nucleus membrane http://togogenome.org/gene/8083:rps2 ^@ http://purl.uniprot.org/uniprot/M4AKG1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/8083:ak6 ^@ http://purl.uniprot.org/uniprot/A0A3B5PXF4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.|||Cajal body|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer and homodimer. Interacts with COIL (via C-terminus).|||nucleoplasm http://togogenome.org/gene/8083:gab3 ^@ http://purl.uniprot.org/uniprot/M4ACZ2 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/8083:actn3 ^@ http://purl.uniprot.org/uniprot/M4A1W1 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/8083:LOC102223405 ^@ http://purl.uniprot.org/uniprot/A0A3B5QYV4 ^@ Similarity ^@ Belongs to the BZW family. http://togogenome.org/gene/8083:fam98a ^@ http://purl.uniprot.org/uniprot/M4ANK6 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/8083:LOC102230735 ^@ http://purl.uniprot.org/uniprot/M4ATE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102226884 ^@ http://purl.uniprot.org/uniprot/M4AR31 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds equally well IGF1 and IGF2.|||IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:homer2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QT49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/8083:unc45a ^@ http://purl.uniprot.org/uniprot/M3ZF86 ^@ Subcellular Location Annotation ^@ perinuclear region http://togogenome.org/gene/8083:manbal ^@ http://purl.uniprot.org/uniprot/A0A3B5QQN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0239 family.|||Membrane http://togogenome.org/gene/8083:efhb ^@ http://purl.uniprot.org/uniprot/A0A3B5R5Y3 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/8083:LOC102220398 ^@ http://purl.uniprot.org/uniprot/M4A402 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Mitochondrion|||Nucleus|||centrosome|||spindle http://togogenome.org/gene/8083:ncoa1 ^@ http://purl.uniprot.org/uniprot/M4ATN1 ^@ Similarity ^@ Belongs to the SRC/p160 nuclear receptor coactivator family. http://togogenome.org/gene/8083:add2 ^@ http://purl.uniprot.org/uniprot/M3ZR35 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/8083:LOC102217150 ^@ http://purl.uniprot.org/uniprot/M4A1X4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/8083:LOC102228764 ^@ http://purl.uniprot.org/uniprot/M4A5C3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. http://togogenome.org/gene/8083:prim1 ^@ http://purl.uniprot.org/uniprot/M4ASN0 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/8083:nop56 ^@ http://purl.uniprot.org/uniprot/M3ZGI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus http://togogenome.org/gene/8083:acyp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q242 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/8083:LOC102220186 ^@ http://purl.uniprot.org/uniprot/M4A6E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:rnft2 ^@ http://purl.uniprot.org/uniprot/M3ZJS7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:ints13 ^@ http://purl.uniprot.org/uniprot/M3ZP82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the asunder family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:fam160a1 ^@ http://purl.uniprot.org/uniprot/M4A0W1 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/8083:eva1a ^@ http://purl.uniprot.org/uniprot/A0A3B5R0N7 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/8083:LOC102227147 ^@ http://purl.uniprot.org/uniprot/A0A3B5QDX4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102233026 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:LOC102226727 ^@ http://purl.uniprot.org/uniprot/M3ZY83 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102224601 ^@ http://purl.uniprot.org/uniprot/M3ZU03 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE4 family.|||Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.|||Component of the SMC5-SMC6 complex.|||Nucleus|||telomere http://togogenome.org/gene/8083:LOC102222302 ^@ http://purl.uniprot.org/uniprot/M4ARC3 ^@ Similarity ^@ Belongs to the SMARCD family. http://togogenome.org/gene/8083:LOC102235486 ^@ http://purl.uniprot.org/uniprot/A0A3B5QSR2 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8083:mvk ^@ http://purl.uniprot.org/uniprot/M4A0N8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.|||Cytoplasm http://togogenome.org/gene/8083:LOC102236927 ^@ http://purl.uniprot.org/uniprot/M4AC97 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/8083:cryaa ^@ http://purl.uniprot.org/uniprot/A0A3B5R4J0 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/8083:LOC102234375 ^@ http://purl.uniprot.org/uniprot/M4AU26 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/8083:LOC102229945 ^@ http://purl.uniprot.org/uniprot/A0A3B5QYX7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102236856 ^@ http://purl.uniprot.org/uniprot/M3ZH75 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/8083:myo19 ^@ http://purl.uniprot.org/uniprot/M3ZTN8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/8083:ercc1 ^@ http://purl.uniprot.org/uniprot/M4AMZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERCC1/RAD10/SWI10 family.|||Nucleus http://togogenome.org/gene/8083:scpep1 ^@ http://purl.uniprot.org/uniprot/M3ZMP0 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/8083:mdh1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8U9|||http://purl.uniprot.org/uniprot/M3ZUK4 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family.|||Homodimer. http://togogenome.org/gene/8083:LOC102237407 ^@ http://purl.uniprot.org/uniprot/M3ZY33 ^@ Similarity ^@ Belongs to the GPI family. http://togogenome.org/gene/8083:LOC102222330 ^@ http://purl.uniprot.org/uniprot/A0A3B5R5E5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:ak2 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDI6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK2 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Mitochondrion intermembrane space|||Monomer. http://togogenome.org/gene/8083:LOC102218596 ^@ http://purl.uniprot.org/uniprot/M3ZWX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102221813 ^@ http://purl.uniprot.org/uniprot/M4A304 ^@ Similarity ^@ Belongs to the DOK family. Type A subfamily. http://togogenome.org/gene/8083:csnk1g1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QMW4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/8083:rps16 ^@ http://purl.uniprot.org/uniprot/A0A3B5QYP0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/8083:LOC102218499 ^@ http://purl.uniprot.org/uniprot/M4A9Y8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LIS1/nudF family.|||Can self-associate. Component of the cytosolic PAF-AH (I) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity (By similarity). Interacts with dynein, dynactin, nde1 and ndel1.|||Can self-associate. Interacts with dynein, dynactin, NDE1 and NDEL1.|||Dimerization mediated by the LisH domain may be required to activate dynein.|||Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.|||centrosome|||cytoskeleton http://togogenome.org/gene/8083:pappa ^@ http://purl.uniprot.org/uniprot/M3ZU65 ^@ Caution|||Similarity ^@ Belongs to the peptidase M43B family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:e2f4 ^@ http://purl.uniprot.org/uniprot/M3ZID0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/8083:bloc1s2 ^@ http://purl.uniprot.org/uniprot/M4A9P2 ^@ Similarity ^@ Belongs to the BLOC1S2 family. http://togogenome.org/gene/8083:LOC102222767 ^@ http://purl.uniprot.org/uniprot/M3ZRV9 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/8083:rcl1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PWR4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.|||Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.|||nucleolus http://togogenome.org/gene/8083:dimt1 ^@ http://purl.uniprot.org/uniprot/M3ZY81 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/8083:allc ^@ http://purl.uniprot.org/uniprot/A0A3B5QYG2 ^@ Similarity ^@ Belongs to the allantoicase family. http://togogenome.org/gene/8083:nadk ^@ http://purl.uniprot.org/uniprot/M4AY92 ^@ Similarity ^@ Belongs to the NAD kinase family. http://togogenome.org/gene/8083:LOC102225087 ^@ http://purl.uniprot.org/uniprot/M4AX46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM54 family.|||Membrane http://togogenome.org/gene/8083:LOC102233202 ^@ http://purl.uniprot.org/uniprot/M4ANV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:egr1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PNR1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus|||Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. http://togogenome.org/gene/8083:LOC102230338 ^@ http://purl.uniprot.org/uniprot/M4A8V4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the cyclin family. Cyclin AB subfamily.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition.|||Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. http://togogenome.org/gene/8083:LOC102228375 ^@ http://purl.uniprot.org/uniprot/M4AE55 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:acat2 ^@ http://purl.uniprot.org/uniprot/M3ZMB5 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/8083:LOC102228168 ^@ http://purl.uniprot.org/uniprot/M4A273 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102226889 ^@ http://purl.uniprot.org/uniprot/A0A3B5QR68 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102224276 ^@ http://purl.uniprot.org/uniprot/M4AR79 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/8083:alx3 ^@ http://purl.uniprot.org/uniprot/M4A6N9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102221482 ^@ http://purl.uniprot.org/uniprot/A0A3B5R904 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102227595 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7P0 ^@ Subcellular Location Annotation ^@ Synapse|||axon|||dendritic spine http://togogenome.org/gene/8083:fam192a ^@ http://purl.uniprot.org/uniprot/M3ZVK7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102228846 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQZ2 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/8083:LOC102216808 ^@ http://purl.uniprot.org/uniprot/M4AZS9 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/8083:tsc22d2 ^@ http://purl.uniprot.org/uniprot/M3ZRD4 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/8083:pggt1b ^@ http://purl.uniprot.org/uniprot/A0A3B5PZ11 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit beta family. http://togogenome.org/gene/8083:LOC102230371 ^@ http://purl.uniprot.org/uniprot/M4AR62 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:hip1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QB04 ^@ Similarity ^@ Belongs to the SLA2 family. http://togogenome.org/gene/8083:LOC102220383 ^@ http://purl.uniprot.org/uniprot/M3ZLK1 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/8083:pdpk1 ^@ http://purl.uniprot.org/uniprot/M4AWV4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. http://togogenome.org/gene/8083:LOC102219510 ^@ http://purl.uniprot.org/uniprot/M4AJN1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus|||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. http://togogenome.org/gene/8083:LOC102217715 ^@ http://purl.uniprot.org/uniprot/M4A255 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/8083:LOC102236340 ^@ http://purl.uniprot.org/uniprot/M4ATN3 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/8083:pdia3 ^@ http://purl.uniprot.org/uniprot/M4AF75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/8083:recql5 ^@ http://purl.uniprot.org/uniprot/M4ACJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RecQ subfamily.|||Nucleus http://togogenome.org/gene/8083:LOC102225896 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q143 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/8083:LOC102221483 ^@ http://purl.uniprot.org/uniprot/M3ZFB6 ^@ Function|||Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. http://togogenome.org/gene/8083:LOC102234763 ^@ http://purl.uniprot.org/uniprot/M4A717 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8083:LOC102221308 ^@ http://purl.uniprot.org/uniprot/M4AQV1 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||May be an activator of the JNK/SAPK pathway. http://togogenome.org/gene/8083:washc5 ^@ http://purl.uniprot.org/uniprot/M4A2H4 ^@ Similarity ^@ Belongs to the strumpellin family. http://togogenome.org/gene/8083:agk ^@ http://purl.uniprot.org/uniprot/M3ZTF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AGK family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/8083:sez6l2 ^@ http://purl.uniprot.org/uniprot/M4AAX8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:smad9 ^@ http://purl.uniprot.org/uniprot/M4A2C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102217811 ^@ http://purl.uniprot.org/uniprot/M4AAP4 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/8083:med17 ^@ http://purl.uniprot.org/uniprot/M3ZZZ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 17 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/8083:phox2a ^@ http://purl.uniprot.org/uniprot/A0A3B5QAU1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102221525 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q554|||http://purl.uniprot.org/uniprot/A0A3B5QCZ3|||http://purl.uniprot.org/uniprot/M3ZDH5 ^@ Similarity ^@ Belongs to the serpin family.|||Belongs to the serpin family. Ov-serpin subfamily. http://togogenome.org/gene/8083:LOC102222487 ^@ http://purl.uniprot.org/uniprot/A0A3B5QL92 ^@ Similarity ^@ Belongs to the proteasome subunit S5A family. http://togogenome.org/gene/8083:LOC102236075 ^@ http://purl.uniprot.org/uniprot/M3ZUZ6 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/8083:ufd1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8H7 ^@ Similarity ^@ Belongs to the UFD1 family. http://togogenome.org/gene/8083:gstk1 ^@ http://purl.uniprot.org/uniprot/M4AB03 ^@ Similarity ^@ Belongs to the GST superfamily. Kappa family. http://togogenome.org/gene/8083:vip ^@ http://purl.uniprot.org/uniprot/M4ARW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/8083:nup133 ^@ http://purl.uniprot.org/uniprot/M4AI84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin Nup133 family.|||nuclear pore complex http://togogenome.org/gene/8083:LOC102234596 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDZ6 ^@ Similarity|||Subunit ^@ Belongs to the 14-3-3 family.|||Homodimer, and heterodimer with other family members. http://togogenome.org/gene/8083:tcea1 ^@ http://purl.uniprot.org/uniprot/M4AT39 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/8083:LOC102221875 ^@ http://purl.uniprot.org/uniprot/A0A3B5QDF4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:hoxc6 ^@ http://purl.uniprot.org/uniprot/M3ZHG0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:ubiad1 ^@ http://purl.uniprot.org/uniprot/M4ADH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Membrane http://togogenome.org/gene/8083:LOC102218720 ^@ http://purl.uniprot.org/uniprot/M4AJK4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus|||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. http://togogenome.org/gene/8083:mlf1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QZQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLF family.|||Cytoplasm http://togogenome.org/gene/8083:LOC102233559 ^@ http://purl.uniprot.org/uniprot/M4AYK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:kcnd1 ^@ http://purl.uniprot.org/uniprot/M4AL93 ^@ Subcellular Location Annotation ^@ Membrane|||dendrite http://togogenome.org/gene/8083:LOC102235998 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q5J7 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/8083:pskh1 ^@ http://purl.uniprot.org/uniprot/M3ZL56 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:dlk1 ^@ http://purl.uniprot.org/uniprot/M3ZZV9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102232461 ^@ http://purl.uniprot.org/uniprot/A0A3B5QXD8 ^@ Similarity ^@ In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family. http://togogenome.org/gene/8083:acads ^@ http://purl.uniprot.org/uniprot/A0A3B5QYG8 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/8083:gja10 ^@ http://purl.uniprot.org/uniprot/M4AJ04 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8083:dars ^@ http://purl.uniprot.org/uniprot/M3ZN97 ^@ Function|||Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. http://togogenome.org/gene/8083:gdpgp1 ^@ http://purl.uniprot.org/uniprot/M4B0Q4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GDPGP1 family.|||Cytoplasm|||Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells. http://togogenome.org/gene/8083:LOC102223523 ^@ http://purl.uniprot.org/uniprot/A0A3B5R3S6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/8083:LOC102220068 ^@ http://purl.uniprot.org/uniprot/M3ZJP1 ^@ Similarity ^@ Belongs to the centaurin gamma-like family. http://togogenome.org/gene/8083:LOC102236381 ^@ http://purl.uniprot.org/uniprot/M4A3G3 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/8083:LOC102217658 ^@ http://purl.uniprot.org/uniprot/A0A3B5RDQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8083:LOC102233547 ^@ http://purl.uniprot.org/uniprot/A0A3B5QWP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CART family.|||Secreted http://togogenome.org/gene/8083:LOC102228761 ^@ http://purl.uniprot.org/uniprot/M3ZMP4 ^@ Function|||Similarity ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. http://togogenome.org/gene/8083:enoph1 ^@ http://purl.uniprot.org/uniprot/M4AXJ0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.|||Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/8083:jmy ^@ http://purl.uniprot.org/uniprot/M4AWA5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:gclm ^@ http://purl.uniprot.org/uniprot/M3ZMB6 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.|||Heterodimer of a catalytic heavy chain and a regulatory light chain. http://togogenome.org/gene/8083:synpr ^@ http://purl.uniprot.org/uniprot/A0A3B5QE85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/8083:cpq ^@ http://purl.uniprot.org/uniprot/M4A8U2 ^@ Subcellular Location Annotation|||Subunit ^@ Endoplasmic reticulum|||Golgi apparatus|||Homodimer. The monomeric form is inactive while the homodimer is active.|||Lysosome http://togogenome.org/gene/8083:LOC102217186 ^@ http://purl.uniprot.org/uniprot/M4AIA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:tmem134 ^@ http://purl.uniprot.org/uniprot/M4A647 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Membrane http://togogenome.org/gene/8083:adam10 ^@ http://purl.uniprot.org/uniprot/M4AJ33 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:LOC102223222 ^@ http://purl.uniprot.org/uniprot/M4AR42 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:fbxo45 ^@ http://purl.uniprot.org/uniprot/A0A3B5R9L3 ^@ Similarity ^@ Belongs to the FBXO45/Fsn family. http://togogenome.org/gene/8083:LOC102217180 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8Y5|||http://purl.uniprot.org/uniprot/A0A3B5QGS5 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family. http://togogenome.org/gene/8083:LOC102219430 ^@ http://purl.uniprot.org/uniprot/M3ZIG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/8083:slc22a18 ^@ http://purl.uniprot.org/uniprot/M4A7A0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102222749 ^@ http://purl.uniprot.org/uniprot/M3ZYW1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Heterodimer with ARID3A. Interacts with unphosphorylated RB1.|||Nucleus|||Transcription factor. http://togogenome.org/gene/8083:slc44a5 ^@ http://purl.uniprot.org/uniprot/M4AFE5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/8083:LOC102235316 ^@ http://purl.uniprot.org/uniprot/M4AHS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/8083:crb2 ^@ http://purl.uniprot.org/uniprot/M3ZNZ3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:sgk3 ^@ http://purl.uniprot.org/uniprot/M3ZHF4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/8083:LOC102227098 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3N4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/8083:LOC102229551 ^@ http://purl.uniprot.org/uniprot/M3ZNV9 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.|||Nucleus http://togogenome.org/gene/8083:LOC102216442 ^@ http://purl.uniprot.org/uniprot/A0A3B5QLH4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102234410 ^@ http://purl.uniprot.org/uniprot/M4A8Z9 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/8083:LOC102224230 ^@ http://purl.uniprot.org/uniprot/M4AVD5 ^@ Similarity|||Subunit ^@ Belongs to the aerobic coproporphyrinogen-III oxidase family.|||Homodimer. http://togogenome.org/gene/8083:LOC102219594 ^@ http://purl.uniprot.org/uniprot/M3ZZM2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102229818 ^@ http://purl.uniprot.org/uniprot/M3ZRP3 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/8083:LOC102227726 ^@ http://purl.uniprot.org/uniprot/M4A0C8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/8083:slc25a40 ^@ http://purl.uniprot.org/uniprot/M3ZXE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:LOC102235935 ^@ http://purl.uniprot.org/uniprot/M4APW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/8083:itpk1 ^@ http://purl.uniprot.org/uniprot/M4AGL1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the ITPK1 family.|||Binds 2 magnesium ions per subunit.|||Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.|||Monomer. http://togogenome.org/gene/8083:banp ^@ http://purl.uniprot.org/uniprot/M3ZFT3 ^@ Similarity ^@ Belongs to the BANP/SMAR1 family. http://togogenome.org/gene/8083:LOC102237680 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0T0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:slc25a48 ^@ http://purl.uniprot.org/uniprot/A0A3B5QN19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:dclre1a ^@ http://purl.uniprot.org/uniprot/M4A115 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/8083:perp ^@ http://purl.uniprot.org/uniprot/M4AMR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/8083:impa1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PPT4 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/8083:LOC102219072 ^@ http://purl.uniprot.org/uniprot/M4ATZ5 ^@ Similarity ^@ Belongs to the PP1 inhibitor family. http://togogenome.org/gene/8083:c7h3orf70 ^@ http://purl.uniprot.org/uniprot/A0A3B5RC36 ^@ Similarity ^@ Belongs to the UPF0524 family. http://togogenome.org/gene/8083:letmd1 ^@ http://purl.uniprot.org/uniprot/M4AB68 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:csnk1d ^@ http://purl.uniprot.org/uniprot/M3ZMK6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8083:LOC102233529 ^@ http://purl.uniprot.org/uniprot/A0A3B5QEL4 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-1 subfamily. http://togogenome.org/gene/8083:tceanc2 ^@ http://purl.uniprot.org/uniprot/M3ZE13 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:tm4sf5 ^@ http://purl.uniprot.org/uniprot/M4A195 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/8083:bcap29 ^@ http://purl.uniprot.org/uniprot/M4A1Y7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.|||Membrane http://togogenome.org/gene/8083:nus1 ^@ http://purl.uniprot.org/uniprot/M3ZSW2 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/8083:hadhb ^@ http://purl.uniprot.org/uniprot/M3ZVH9 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/8083:ogt ^@ http://purl.uniprot.org/uniprot/M4A4Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.|||Cell projection|||Mitochondrion membrane http://togogenome.org/gene/8083:LOC102218075 ^@ http://purl.uniprot.org/uniprot/A0A3B5PTK3 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/8083:rbpms2 ^@ http://purl.uniprot.org/uniprot/M3ZG67 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:sncb ^@ http://purl.uniprot.org/uniprot/M4A6U3 ^@ Similarity ^@ Belongs to the synuclein family. http://togogenome.org/gene/8083:hadha ^@ http://purl.uniprot.org/uniprot/M4AMP8 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/8083:vps4a ^@ http://purl.uniprot.org/uniprot/M4ANX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/8083:pde4c ^@ http://purl.uniprot.org/uniprot/M4AMA1 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/8083:zgpat ^@ http://purl.uniprot.org/uniprot/M3ZRC9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:LOC102228924 ^@ http://purl.uniprot.org/uniprot/A0A3B5PTW9 ^@ Similarity ^@ Belongs to the opioid growth factor receptor family. http://togogenome.org/gene/8083:yeats4 ^@ http://purl.uniprot.org/uniprot/M3ZMP5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:cks1b ^@ http://purl.uniprot.org/uniprot/A0A3B5QHA6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/8083:tmem38a ^@ http://purl.uniprot.org/uniprot/A0A3B5R3L5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/8083:tm9sf3 ^@ http://purl.uniprot.org/uniprot/M4A0P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/8083:yaf2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QV25 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:srfbp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PWM7 ^@ Function ^@ May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells. http://togogenome.org/gene/8083:romo1 ^@ http://purl.uniprot.org/uniprot/M4AN38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGR2 family.|||Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.|||Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.|||Mitochondrion inner membrane http://togogenome.org/gene/8083:atxn1 ^@ http://purl.uniprot.org/uniprot/M3ZN32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATXN1 family.|||Nucleus http://togogenome.org/gene/8083:elmo1 ^@ http://purl.uniprot.org/uniprot/M3ZKV3 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/8083:LOC102226156 ^@ http://purl.uniprot.org/uniprot/M4A9E4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/8083:LOC102229998 ^@ http://purl.uniprot.org/uniprot/M4AZK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/8083:LOC102238067 ^@ http://purl.uniprot.org/uniprot/A0A3B5QM05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/8083:LOC102238104 ^@ http://purl.uniprot.org/uniprot/A0A3B5RFJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8083:mmp23b ^@ http://purl.uniprot.org/uniprot/M4ADI4 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:cers1 ^@ http://purl.uniprot.org/uniprot/M4AWC2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102225050 ^@ http://purl.uniprot.org/uniprot/A0A3B5PVB9 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/8083:nanos3 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q4Q2 ^@ Similarity ^@ Belongs to the nanos family. http://togogenome.org/gene/8083:LOC102228070 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/8083:LOC102226088 ^@ http://purl.uniprot.org/uniprot/M4A7S0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102233892 ^@ http://purl.uniprot.org/uniprot/M4AAB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/8083:nagk ^@ http://purl.uniprot.org/uniprot/M4A301 ^@ Similarity ^@ Belongs to the eukaryotic-type N-acetylglucosamine kinase family. http://togogenome.org/gene/8083:mcm3 ^@ http://purl.uniprot.org/uniprot/M4A020 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/8083:utp15 ^@ http://purl.uniprot.org/uniprot/M4AIF5 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/8083:arl6ip5 ^@ http://purl.uniprot.org/uniprot/A0A3B5QS37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/8083:b4galt5 ^@ http://purl.uniprot.org/uniprot/M4AMA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/8083:rassf1 ^@ http://purl.uniprot.org/uniprot/M4AR36 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/8083:gpr161 ^@ http://purl.uniprot.org/uniprot/A0A3B5QNE7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:phpt1 ^@ http://purl.uniprot.org/uniprot/M3ZLH2 ^@ Function|||Similarity ^@ Belongs to the janus family.|||Exhibits phosphohistidine phosphatase activity. http://togogenome.org/gene/8083:LOC102227888 ^@ http://purl.uniprot.org/uniprot/M4AV99 ^@ Similarity ^@ Belongs to the RUNDC3 family. http://togogenome.org/gene/8083:LOC102234924 ^@ http://purl.uniprot.org/uniprot/M4AZS6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:tmem165 ^@ http://purl.uniprot.org/uniprot/M4AR97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GDT1 family.|||Membrane http://togogenome.org/gene/8083:dclre1b ^@ http://purl.uniprot.org/uniprot/M4A6Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/8083:LOC102224557 ^@ http://purl.uniprot.org/uniprot/M4A9Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8083:LOC102222334 ^@ http://purl.uniprot.org/uniprot/M4ATN5 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/8083:irf2bp2 ^@ http://purl.uniprot.org/uniprot/A0A3B5QIQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF2BP family.|||Nucleus http://togogenome.org/gene/8083:atad1 ^@ http://purl.uniprot.org/uniprot/M4AJ31 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/8083:LOC102224133 ^@ http://purl.uniprot.org/uniprot/M4AMI3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:obsl1 ^@ http://purl.uniprot.org/uniprot/M3ZE90 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102231548 ^@ http://purl.uniprot.org/uniprot/M3ZTV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyltransferase family.|||Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.|||Membrane http://togogenome.org/gene/8083:LOC102227442 ^@ http://purl.uniprot.org/uniprot/M3ZH82 ^@ Similarity|||Subunit ^@ Belongs to the ENDOU family.|||Monomer. http://togogenome.org/gene/8083:LOC102218443 ^@ http://purl.uniprot.org/uniprot/A0A3B5QQ67 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus|||Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. http://togogenome.org/gene/8083:gpr83 ^@ http://purl.uniprot.org/uniprot/A0A3B5PZX3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8083:terf1 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q8U7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.|||Homodimer.|||Nucleus http://togogenome.org/gene/8083:nosip ^@ http://purl.uniprot.org/uniprot/M3ZK59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOSIP family.|||Cytoplasm|||Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity.|||Nucleus http://togogenome.org/gene/8083:LOC102216692 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q3I6 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/8083:LOC102231004 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q681 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/8083:rab3c ^@ http://purl.uniprot.org/uniprot/A0A3B5PX78|||http://purl.uniprot.org/uniprot/A0A3B5QLM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/8083:LOC102218161 ^@ http://purl.uniprot.org/uniprot/M4AT45 ^@ Similarity ^@ Belongs to the parvin family. http://togogenome.org/gene/8083:LOC102234590 ^@ http://purl.uniprot.org/uniprot/A0A3B5R8R4 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/8083:LOC102216603 ^@ http://purl.uniprot.org/uniprot/M4A1D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/8083:gja1 ^@ http://purl.uniprot.org/uniprot/M3ZST0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8083:LOC102234567 ^@ http://purl.uniprot.org/uniprot/M3ZKJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/8083:LOC102217254 ^@ http://purl.uniprot.org/uniprot/M3ZST8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/8083:mrgbp ^@ http://purl.uniprot.org/uniprot/M3ZM57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EAF7 family.|||Nucleus http://togogenome.org/gene/8083:fitm2 ^@ http://purl.uniprot.org/uniprot/M3ZG59 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8083:cpn1 ^@ http://purl.uniprot.org/uniprot/A0A3B5R653 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/8083:LOC102227507 ^@ http://purl.uniprot.org/uniprot/M3ZIS5 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/8083:ung ^@ http://purl.uniprot.org/uniprot/A0A3B5R430|||http://purl.uniprot.org/uniprot/M4AUZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.|||Mitochondrion|||Nucleus http://togogenome.org/gene/8083:mab21l1 ^@ http://purl.uniprot.org/uniprot/M4B0M9 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/8083:LOC102222765 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBP4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:lancl3 ^@ http://purl.uniprot.org/uniprot/A0A3B5R874 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/8083:acadvl ^@ http://purl.uniprot.org/uniprot/M4AM24 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/8083:LOC102216954 ^@ http://purl.uniprot.org/uniprot/M4AHJ4 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/8083:park7 ^@ http://purl.uniprot.org/uniprot/A0A3B5QMZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C56 family.|||Membrane raft http://togogenome.org/gene/8083:actb ^@ http://purl.uniprot.org/uniprot/A0A3B5QYT5 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/8083:LOC102235418 ^@ http://purl.uniprot.org/uniprot/A0A3B5PZI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tumor necrosis factor family.|||Membrane|||Secreted http://togogenome.org/gene/8083:LOC102232717 ^@ http://purl.uniprot.org/uniprot/A0A3B5RCL0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/8083:LOC102229416 ^@ http://purl.uniprot.org/uniprot/M4ATX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Secreted http://togogenome.org/gene/8083:LOC102224016 ^@ http://purl.uniprot.org/uniprot/A0A3B5R8J8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP2 family.|||Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.|||Membrane http://togogenome.org/gene/8083:LOC102221139 ^@ http://purl.uniprot.org/uniprot/M4AQG1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102225745 ^@ http://purl.uniprot.org/uniprot/M3ZGP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane http://togogenome.org/gene/8083:LOC102228479 ^@ http://purl.uniprot.org/uniprot/M4ASK8 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:med19 ^@ http://purl.uniprot.org/uniprot/M4A5U6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 19 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/8083:pcsk9 ^@ http://purl.uniprot.org/uniprot/M4A9J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S8 family.|||Cell surface|||Cytoplasm|||Endoplasmic reticulum|||Endosome|||Golgi apparatus|||Lysosome http://togogenome.org/gene/8083:ppm1b ^@ http://purl.uniprot.org/uniprot/A0A3B5R408 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/8083:c9h1orf52 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q407 ^@ Similarity ^@ Belongs to the UPF0690 family. http://togogenome.org/gene/8083:creg1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QC41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CREG family.|||Secreted http://togogenome.org/gene/8083:tmem115 ^@ http://purl.uniprot.org/uniprot/M4AY71 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102224433 ^@ http://purl.uniprot.org/uniprot/M3ZPD1 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/8083:LOC102219264 ^@ http://purl.uniprot.org/uniprot/M3ZL66 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/8083:LOC102232678 ^@ http://purl.uniprot.org/uniprot/M4AQN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/8083:alkbh8 ^@ http://purl.uniprot.org/uniprot/M4A8W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alkB family.|||Cytoplasm http://togogenome.org/gene/8083:rps17 ^@ http://purl.uniprot.org/uniprot/A0A3B5QTD6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/8083:utp6 ^@ http://purl.uniprot.org/uniprot/M4ASM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP6 family.|||nucleolus http://togogenome.org/gene/8083:syt1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PTX3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||synaptic vesicle membrane http://togogenome.org/gene/8083:fgf14 ^@ http://purl.uniprot.org/uniprot/A0A3B5R057 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8083:LOC102236004 ^@ http://purl.uniprot.org/uniprot/A0A3B5QT95 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/8083:wisp2 ^@ http://purl.uniprot.org/uniprot/M3ZGC8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8083:dad1 ^@ http://purl.uniprot.org/uniprot/M3ZV58 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAD/OST2 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/8083:LOC102221598 ^@ http://purl.uniprot.org/uniprot/M3ZFU2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102218958 ^@ http://purl.uniprot.org/uniprot/M3ZP27 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:LOC102220789 ^@ http://purl.uniprot.org/uniprot/M4AQQ8 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/8083:LOC102217906 ^@ http://purl.uniprot.org/uniprot/A0A3B5QCK6 ^@ Similarity ^@ Belongs to the parvin family. http://togogenome.org/gene/8083:efemp2 ^@ http://purl.uniprot.org/uniprot/M4AFF4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8083:ehhadh ^@ http://purl.uniprot.org/uniprot/A0A3B5R1P6 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/8083:plekha8 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q0F7 ^@ Subcellular Location Annotation ^@ trans-Golgi network membrane http://togogenome.org/gene/8083:LOC102232388 ^@ http://purl.uniprot.org/uniprot/M4AAZ7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:KEG86_p03 ^@ http://purl.uniprot.org/uniprot/B5WZ61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 5 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8083:LOC102223724 ^@ http://purl.uniprot.org/uniprot/M4A8K4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/8083:adgrl1 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBQ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8083:gnas ^@ http://purl.uniprot.org/uniprot/A0A3B5QE13 ^@ Similarity ^@ Belongs to the G-alpha family. G(s) subfamily. http://togogenome.org/gene/8083:LOC102221886 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7S7 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/8083:sf3a1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PTY0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8083:hcrtr2 ^@ http://purl.uniprot.org/uniprot/M4A6Y2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102219024 ^@ http://purl.uniprot.org/uniprot/A0A3B5REQ9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/8083:LOC102223556 ^@ http://purl.uniprot.org/uniprot/A0A3B5Q2L9 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/8083:csad ^@ http://purl.uniprot.org/uniprot/M4A107 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/8083:ccdc34 ^@ http://purl.uniprot.org/uniprot/A0A3B5PXB1 ^@ Subcellular Location Annotation ^@ flagellum http://togogenome.org/gene/8083:kcnk12 ^@ http://purl.uniprot.org/uniprot/M4A971 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/8083:LOC102216929 ^@ http://purl.uniprot.org/uniprot/M4ABA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8083:leprotl1 ^@ http://purl.uniprot.org/uniprot/A0A3B5QI46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/8083:lasp1 ^@ http://purl.uniprot.org/uniprot/A0A3B5PW39 ^@ Function|||Subcellular Location Annotation ^@ Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.|||cell cortex|||cytoskeleton http://togogenome.org/gene/8083:LOC102237004 ^@ http://purl.uniprot.org/uniprot/M4B0J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/8083:txnl4b ^@ http://purl.uniprot.org/uniprot/M4AXP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/8083:LOC102222285 ^@ http://purl.uniprot.org/uniprot/A0A3B5RBB2 ^@ Similarity ^@ Belongs to the SERF family. http://togogenome.org/gene/8083:LOC102220591 ^@ http://purl.uniprot.org/uniprot/A0A3B5R256 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/8083:tram2 ^@ http://purl.uniprot.org/uniprot/M3ZMH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/8083:slbp ^@ http://purl.uniprot.org/uniprot/M3ZGI2 ^@ Similarity ^@ Belongs to the SLBP family. http://togogenome.org/gene/8083:mmachc ^@ http://purl.uniprot.org/uniprot/M4AAL2 ^@ Similarity ^@ Belongs to the MMACHC family. http://togogenome.org/gene/8083:LOC102227014 ^@ http://purl.uniprot.org/uniprot/M4AXY5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/8083:casr ^@ http://purl.uniprot.org/uniprot/M4AEV2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102238336 ^@ http://purl.uniprot.org/uniprot/M3ZDC9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/8083:LOC102223561 ^@ http://purl.uniprot.org/uniprot/M4A058 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8083:arrdc3 ^@ http://purl.uniprot.org/uniprot/A0A3B5PUH0 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/8083:LOC102219781 ^@ http://purl.uniprot.org/uniprot/M4A9J3 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||desmosome http://togogenome.org/gene/8083:atp11c ^@ http://purl.uniprot.org/uniprot/A0A3B5QP42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/8083:vangl2 ^@ http://purl.uniprot.org/uniprot/A0A3B5R7U0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/8083:LOC102217278 ^@ http://purl.uniprot.org/uniprot/A0A3B5QGW3 ^@ Similarity ^@ Belongs to the intercrine alpha (chemokine CxC) family. http://togogenome.org/gene/8083:psmd12 ^@ http://purl.uniprot.org/uniprot/A0A3B5QXX0 ^@ Similarity ^@ Belongs to the proteasome subunit p55 family. http://togogenome.org/gene/8083:emp2 ^@ http://purl.uniprot.org/uniprot/M3ZDC7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8083:LOC102226343 ^@ http://purl.uniprot.org/uniprot/M4AHD4 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/8083:LOC102235022 ^@ http://purl.uniprot.org/uniprot/M3ZSB0 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/8083:ace ^@ http://purl.uniprot.org/uniprot/M4AJE2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M2 family.|||Binds 2 Zn(2+) ions per subunit.