http://togogenome.org/gene/879243:PORAS_RS01650 ^@ http://purl.uniprot.org/uniprot/F4KMN9 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/879243:PORAS_RS00865 ^@ http://purl.uniprot.org/uniprot/F4KLM1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS04435 ^@ http://purl.uniprot.org/uniprot/F4KKA7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS03375 ^@ http://purl.uniprot.org/uniprot/F4KJQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase Y family.|||Cell membrane|||Endoribonuclease that initiates mRNA decay. http://togogenome.org/gene/879243:PORAS_RS04140 ^@ http://purl.uniprot.org/uniprot/F4KK50 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/879243:PORAS_RS04820 ^@ http://purl.uniprot.org/uniprot/F4KKI3 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/879243:PORAS_RS05520 ^@ http://purl.uniprot.org/uniprot/F4KL32 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/879243:PORAS_RS01595 ^@ http://purl.uniprot.org/uniprot/F4KMG0 ^@ Similarity ^@ Belongs to the peptidase S41A family. http://togogenome.org/gene/879243:PORAS_RS02425 ^@ http://purl.uniprot.org/uniprot/F4KNI1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/879243:PORAS_RS03685 ^@ http://purl.uniprot.org/uniprot/F4KJW3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/879243:PORAS_RS04670 ^@ http://purl.uniprot.org/uniprot/F4KKF3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS06900 ^@ http://purl.uniprot.org/uniprot/F4KMM0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS08445 ^@ http://purl.uniprot.org/uniprot/F4KJK5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.|||Homotetramer. http://togogenome.org/gene/879243:PORAS_RS03680 ^@ http://purl.uniprot.org/uniprot/F4KJW2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL10 family. http://togogenome.org/gene/879243:PORAS_RS00480 ^@ http://purl.uniprot.org/uniprot/F4KL77 ^@ Domain|||Function|||Similarity ^@ Belongs to the RecA family. RadA subfamily.|||DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.|||Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.|||The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. http://togogenome.org/gene/879243:PORAS_RS02110 ^@ http://purl.uniprot.org/uniprot/F4KN47 ^@ Similarity ^@ Belongs to the peptidase C25 family. http://togogenome.org/gene/879243:PORAS_RS00115 ^@ http://purl.uniprot.org/uniprot/F4KKU6 ^@ Function|||Similarity ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.|||In the C-terminal section; belongs to the NAD synthetase family. http://togogenome.org/gene/879243:PORAS_RS05895 ^@ http://purl.uniprot.org/uniprot/F4KLH3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS01680 ^@ http://purl.uniprot.org/uniprot/F4KMP5 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/879243:PORAS_RS07490 ^@ http://purl.uniprot.org/uniprot/F4KNC4 ^@ Similarity ^@ Belongs to the sigma-54 factor family. http://togogenome.org/gene/879243:PORAS_RS05195 ^@ http://purl.uniprot.org/uniprot/F4KKR1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/879243:PORAS_RS05830 ^@ http://purl.uniprot.org/uniprot/F4KLG0 ^@ Similarity ^@ Belongs to the Skp family. http://togogenome.org/gene/879243:PORAS_RS01600 ^@ http://purl.uniprot.org/uniprot/F4KMG1 ^@ Similarity ^@ Belongs to the type IA topoisomerase family. http://togogenome.org/gene/879243:PORAS_RS08355 ^@ http://purl.uniprot.org/uniprot/F4KJI7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS05060 ^@ http://purl.uniprot.org/uniprot/F4KJD1 ^@ Similarity ^@ Belongs to the bacterial reverse transcriptase family. http://togogenome.org/gene/879243:PORAS_RS07560 ^@ http://purl.uniprot.org/uniprot/F4KND8 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS06435 ^@ http://purl.uniprot.org/uniprot/F4KM60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS08160 ^@ http://purl.uniprot.org/uniprot/F4KP41 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell inner membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS07950 ^@ http://purl.uniprot.org/uniprot/F4KNZ9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. http://togogenome.org/gene/879243:PORAS_RS05610 ^@ http://purl.uniprot.org/uniprot/F4KLB4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/879243:PORAS_RS06525 ^@ http://purl.uniprot.org/uniprot/F4KM78 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/879243:PORAS_RS05640 ^@ http://purl.uniprot.org/uniprot/F4KLC1 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/879243:PORAS_RS03250 ^@ http://purl.uniprot.org/uniprot/F4KJN2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.|||Binds 3 [4Fe-4S] clusters.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/879243:PORAS_RS05470 ^@ http://purl.uniprot.org/uniprot/F4KL21 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/879243:PORAS_RS00440 ^@ http://purl.uniprot.org/uniprot/F4KL69 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/879243:PORAS_RS02485 ^@ http://purl.uniprot.org/uniprot/F4KNJ2 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/879243:PORAS_RS06520 ^@ http://purl.uniprot.org/uniprot/F4KM77 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS05435 ^@ http://purl.uniprot.org/uniprot/F4KL17 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/879243:PORAS_RS02380 ^@ http://purl.uniprot.org/uniprot/F4KNH2 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/879243:PORAS_RS00185 ^@ http://purl.uniprot.org/uniprot/F4KKW0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.|||Cytoplasm|||Monomer. http://togogenome.org/gene/879243:PORAS_RS00050 ^@ http://purl.uniprot.org/uniprot/F4KKT2 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/879243:PORAS_RS01520 ^@ http://purl.uniprot.org/uniprot/F4KME5 ^@ Similarity ^@ Belongs to the RecJ family. http://togogenome.org/gene/879243:PORAS_RS08470 ^@ http://purl.uniprot.org/uniprot/F4KJL0 ^@ Cofactor|||Similarity ^@ Belongs to the alkaline phosphatase family.|||Binds 1 Mg(2+) ion.|||Binds 2 Zn(2+) ions. http://togogenome.org/gene/879243:PORAS_RS01000 ^@ http://purl.uniprot.org/uniprot/F4KLW7 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/879243:PORAS_RS02065 ^@ http://purl.uniprot.org/uniprot/F4KN38 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/879243:PORAS_RS08420 ^@ http://purl.uniprot.org/uniprot/F4KJK0 ^@ Similarity ^@ Belongs to the fabD family. http://togogenome.org/gene/879243:PORAS_RS00830 ^@ http://purl.uniprot.org/uniprot/F4KLL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS03455 ^@ http://purl.uniprot.org/uniprot/F4KJS0 ^@ Similarity ^@ Belongs to the MreC family. http://togogenome.org/gene/879243:PORAS_RS08465 ^@ http://purl.uniprot.org/uniprot/F4KJK9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/879243:PORAS_RS00945 ^@ http://purl.uniprot.org/uniprot/F4KLN7 ^@ Similarity ^@ Belongs to the peptidase S13 family. http://togogenome.org/gene/879243:PORAS_RS03745 ^@ http://purl.uniprot.org/uniprot/F4KJX2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family.|||Homotrimer.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/879243:PORAS_RS05045 ^@ http://purl.uniprot.org/uniprot/F4KKM9 ^@ Similarity ^@ Belongs to the Skp family. http://togogenome.org/gene/879243:PORAS_RS08380 ^@ http://purl.uniprot.org/uniprot/F4KJJ2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit.|||Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. http://togogenome.org/gene/879243:PORAS_RS05170 ^@ http://purl.uniprot.org/uniprot/F4KKQ6 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/879243:PORAS_RS02015 ^@ http://purl.uniprot.org/uniprot/F4KN27 ^@ Similarity ^@ Belongs to the peptidase S46 family. http://togogenome.org/gene/879243:PORAS_RS05210 ^@ http://purl.uniprot.org/uniprot/F4KKR4 ^@ Function|||Similarity ^@ Belongs to the DNA polymerase type-A family.|||In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. http://togogenome.org/gene/879243:PORAS_RS01490 ^@ http://purl.uniprot.org/uniprot/F4KMD6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS08205 ^@ http://purl.uniprot.org/uniprot/F4KP50 ^@ Caution|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS07245 ^@ http://purl.uniprot.org/uniprot/F4KN09 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/879243:PORAS_RS07845 ^@ http://purl.uniprot.org/uniprot/F4KNQ6 ^@ Similarity ^@ Belongs to the peptidase C15 family. http://togogenome.org/gene/879243:PORAS_RS00100 ^@ http://purl.uniprot.org/uniprot/F4KKU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/879243:PORAS_RS04750 ^@ http://purl.uniprot.org/uniprot/F4KKG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/879243:PORAS_RS07450 ^@ http://purl.uniprot.org/uniprot/F4KNB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/879243:PORAS_RS04445 ^@ http://purl.uniprot.org/uniprot/F4KKA9 ^@ Similarity ^@ Belongs to the peptidase C10 family. http://togogenome.org/gene/879243:PORAS_RS03710 ^@ http://purl.uniprot.org/uniprot/F4KJW7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/879243:PORAS_RS04980 ^@ http://purl.uniprot.org/uniprot/F4KKL6 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the thiamine-phosphate synthase family.|||Binds 1 Mg(2+) ion per subunit.|||Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS05460 ^@ http://purl.uniprot.org/uniprot/F4KL19 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.|||Cytoplasm|||Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC). http://togogenome.org/gene/879243:PORAS_RS04540 ^@ http://purl.uniprot.org/uniprot/F4KKC8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS01495 ^@ http://purl.uniprot.org/uniprot/F4KMD7 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/879243:PORAS_RS01700 ^@ http://purl.uniprot.org/uniprot/F4KMP9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/879243:PORAS_RS05395 ^@ http://purl.uniprot.org/uniprot/F4KL09 ^@ Similarity ^@ Belongs to the Mg-chelatase subunits D/I family. ComM subfamily. http://togogenome.org/gene/879243:PORAS_RS05960 ^@ http://purl.uniprot.org/uniprot/F4KLP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/879243:PORAS_RS00920 ^@ http://purl.uniprot.org/uniprot/F4KLN2 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanD family.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.|||Cytoplasm|||Heterooctamer of four alpha and four beta subunits.|||Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus. http://togogenome.org/gene/879243:PORAS_RS02090 ^@ http://purl.uniprot.org/uniprot/F4KN43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urea transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS03605 ^@ http://purl.uniprot.org/uniprot/F4KJU9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS01125 ^@ http://purl.uniprot.org/uniprot/F4KLZ3 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion.|||Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.|||In the C-terminal section; belongs to the HTP reductase family.|||In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/879243:PORAS_RS02325 ^@ http://purl.uniprot.org/uniprot/F4KNF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/879243:PORAS_RS06645 ^@ http://purl.uniprot.org/uniprot/F4KMH0 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/879243:PORAS_RS04915 ^@ http://purl.uniprot.org/uniprot/F4KKK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MenA family. Type 1 subfamily.|||Cell inner membrane|||Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).|||Membrane http://togogenome.org/gene/879243:PORAS_RS05585 ^@ http://purl.uniprot.org/uniprot/F4KLA9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS03690 ^@ http://purl.uniprot.org/uniprot/F4KJW4 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/879243:PORAS_RS05260 ^@ http://purl.uniprot.org/uniprot/F4KKY7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/879243:PORAS_RS03740 ^@ http://purl.uniprot.org/uniprot/F4KJX1 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS01745 ^@ http://purl.uniprot.org/uniprot/F4KMQ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/879243:PORAS_RS02945 ^@ http://purl.uniprot.org/uniprot/F4KJB1 ^@ Function|||Similarity ^@ Belongs to the NadD family.|||Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). http://togogenome.org/gene/879243:PORAS_RS04535 ^@ http://purl.uniprot.org/uniprot/F4KKC7 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/879243:PORAS_RS01415 ^@ http://purl.uniprot.org/uniprot/F4KMC2 ^@ Subcellular Location Annotation ^@ Cell outer membrane|||Fimbrium|||Membrane http://togogenome.org/gene/879243:PORAS_RS03825 ^@ http://purl.uniprot.org/uniprot/F4KJY7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/879243:PORAS_RS05535 ^@ http://purl.uniprot.org/uniprot/F4KL35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell inner membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/879243:PORAS_RS05905 ^@ http://purl.uniprot.org/uniprot/F4KLN8 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/879243:PORAS_RS08265 ^@ http://purl.uniprot.org/uniprot/F4KJG8 ^@ Similarity ^@ Belongs to the peptidase C10 family. http://togogenome.org/gene/879243:PORAS_RS05715 ^@ http://purl.uniprot.org/uniprot/F4KLD7 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.|||Belongs to the peptidase S16 family.|||By heat shock.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity. http://togogenome.org/gene/879243:PORAS_RS03785 ^@ http://purl.uniprot.org/uniprot/F4KJX9 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/879243:PORAS_RS03240 ^@ http://purl.uniprot.org/uniprot/F4KJN0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrB/RnfD family.|||Cell inner membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/879243:PORAS_RS07290 ^@ http://purl.uniprot.org/uniprot/F4KN84 ^@ Similarity ^@ Belongs to the low molecular weight phosphotyrosine protein phosphatase family. http://togogenome.org/gene/879243:PORAS_RS06720 ^@ http://purl.uniprot.org/uniprot/F4KMI6 ^@ Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||GTPase that plays an essential role in the late steps of ribosome biogenesis. http://togogenome.org/gene/879243:PORAS_RS04340 ^@ http://purl.uniprot.org/uniprot/F4KK87 ^@ Cofactor|||Similarity ^@ Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.|||Binds 3 [4Fe-4S] clusters per subunit. http://togogenome.org/gene/879243:PORAS_RS02095 ^@ http://purl.uniprot.org/uniprot/F4KN44 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS01690 ^@ http://purl.uniprot.org/uniprot/F4KMP7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/879243:PORAS_RS07205 ^@ http://purl.uniprot.org/uniprot/F4KN02 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/879243:PORAS_RS01735 ^@ http://purl.uniprot.org/uniprot/F4KMQ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/879243:PORAS_RS05515 ^@ http://purl.uniprot.org/uniprot/F4KL31 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).|||Cell membrane|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. http://togogenome.org/gene/879243:PORAS_RS06705 ^@ http://purl.uniprot.org/uniprot/F4KMI3 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/879243:PORAS_RS04240 ^@ http://purl.uniprot.org/uniprot/F4KK68 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/879243:PORAS_RS00345 ^@ http://purl.uniprot.org/uniprot/F4KL51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/879243:PORAS_RS05700 ^@ http://purl.uniprot.org/uniprot/F4KLD4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/879243:PORAS_RS00725 ^@ http://purl.uniprot.org/uniprot/F4KLJ4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the QueC family.|||Binds 1 zinc ion per subunit.|||Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). http://togogenome.org/gene/879243:PORAS_RS03535 ^@ http://purl.uniprot.org/uniprot/F4KJT4 ^@ Similarity ^@ Belongs to the SBNO family. http://togogenome.org/gene/879243:PORAS_RS02840 ^@ http://purl.uniprot.org/uniprot/F4KNX8 ^@ Similarity ^@ Belongs to the ETF beta-subunit/FixA family. http://togogenome.org/gene/879243:PORAS_RS04210 ^@ http://purl.uniprot.org/uniprot/F4KK62 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS01905 ^@ http://purl.uniprot.org/uniprot/F4KMU2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Belongs to the SecD/SecF family. SecF subfamily.|||Cell inner membrane|||Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/879243:PORAS_RS06565 ^@ http://purl.uniprot.org/uniprot/F4KM85 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/879243:PORAS_RS03135 ^@ http://purl.uniprot.org/uniprot/F4KJE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family.|||Membrane http://togogenome.org/gene/879243:PORAS_RS00385 ^@ http://purl.uniprot.org/uniprot/F4KL59 ^@ Similarity ^@ Belongs to the peptidase M13 family. http://togogenome.org/gene/879243:PORAS_RS01530 ^@ http://purl.uniprot.org/uniprot/F4KME7 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. IspE subfamily.|||Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. http://togogenome.org/gene/879243:PORAS_RS06735 ^@ http://purl.uniprot.org/uniprot/F4KMI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAL/histidase family.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS00365 ^@ http://purl.uniprot.org/uniprot/F4KL55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome ubiquinol oxidase subunit 1 family.|||Membrane http://togogenome.org/gene/879243:PORAS_RS01625 ^@ http://purl.uniprot.org/uniprot/F4KMN4 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/879243:PORAS_RS00075 ^@ http://purl.uniprot.org/uniprot/F4KKT7 ^@ Subcellular Location Annotation ^@ Cell outer membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS08490 ^@ http://purl.uniprot.org/uniprot/F4KJL4 ^@ Similarity ^@ Belongs to the FBPase class 3 family. http://togogenome.org/gene/879243:PORAS_RS06795 ^@ http://purl.uniprot.org/uniprot/F4KMK1 ^@ Function|||Similarity ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. http://togogenome.org/gene/879243:PORAS_RS04975 ^@ http://purl.uniprot.org/uniprot/F4KKL5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ThiG family.|||Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.|||Cytoplasm|||Homotetramer. Forms heterodimers with either ThiH or ThiS. http://togogenome.org/gene/879243:PORAS_RS07110 ^@ http://purl.uniprot.org/uniprot/F4KMY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.|||Cell membrane http://togogenome.org/gene/879243:PORAS_RS02735 ^@ http://purl.uniprot.org/uniprot/F4KNV3 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/879243:PORAS_RS07535 ^@ http://purl.uniprot.org/uniprot/F4KND3 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/879243:PORAS_RS04630 ^@ http://purl.uniprot.org/uniprot/F4KKE5 ^@ Caution|||Function|||Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.|||Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS02855 ^@ http://purl.uniprot.org/uniprot/F4KNY1 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/879243:PORAS_RS02385 ^@ http://purl.uniprot.org/uniprot/F4KNH3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/879243:PORAS_RS06665 ^@ http://purl.uniprot.org/uniprot/F4KMH4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS05720 ^@ http://purl.uniprot.org/uniprot/F4KLD8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS05385 ^@ http://purl.uniprot.org/uniprot/F4KL07 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IspF family.|||Binds 1 divalent metal cation per subunit.|||Homotrimer.|||Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS03875 ^@ http://purl.uniprot.org/uniprot/F4KJZ7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the D-alanine--D-alanine ligase family.|||Binds 2 magnesium or manganese ions per subunit.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS02890 ^@ http://purl.uniprot.org/uniprot/F4KNY8 ^@ Similarity ^@ Belongs to the peptidase C69 family. http://togogenome.org/gene/879243:PORAS_RS04465 ^@ http://purl.uniprot.org/uniprot/F4KJD1 ^@ Similarity ^@ Belongs to the bacterial reverse transcriptase family. http://togogenome.org/gene/879243:PORAS_RS04325 ^@ http://purl.uniprot.org/uniprot/F4KK85 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family.|||Belongs to the peptidase C25 family. http://togogenome.org/gene/879243:PORAS_RS05815 ^@ http://purl.uniprot.org/uniprot/F4KLF7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer. http://togogenome.org/gene/879243:PORAS_RS00340 ^@ http://purl.uniprot.org/uniprot/F4KL50 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/879243:PORAS_RS02235 ^@ http://purl.uniprot.org/uniprot/F4KN73 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.|||Cytoplasm|||Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS07140 ^@ http://purl.uniprot.org/uniprot/F4KMY9 ^@ Subcellular Location Annotation ^@ Cell outer membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS01925 ^@ http://purl.uniprot.org/uniprot/F4KMU6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the transferase hexapeptide repeat family. LpxD subfamily.|||Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.|||Homotrimer. http://togogenome.org/gene/879243:PORAS_RS07480 ^@ http://purl.uniprot.org/uniprot/F4KNC2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/879243:PORAS_RS03475 ^@ http://purl.uniprot.org/uniprot/F4KJS4 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/879243:PORAS_RS04185 ^@ http://purl.uniprot.org/uniprot/F4KK57 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the DnaG primase family.|||Binds 1 zinc ion per monomer.|||Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.|||Monomer. Interacts with DnaB.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/879243:PORAS_RS06450 ^@ http://purl.uniprot.org/uniprot/F4KM63 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/879243:PORAS_RS06005 ^@ http://purl.uniprot.org/uniprot/F4KLQ7 ^@ Similarity ^@ In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family. http://togogenome.org/gene/879243:PORAS_RS00615 ^@ http://purl.uniprot.org/uniprot/F4KLA3 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/879243:PORAS_RS01795 ^@ http://purl.uniprot.org/uniprot/F4KMR8 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/879243:PORAS_RS06285 ^@ http://purl.uniprot.org/uniprot/F4KM30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS08165 ^@ http://purl.uniprot.org/uniprot/F4KP42 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.|||Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/879243:PORAS_RS02215 ^@ http://purl.uniprot.org/uniprot/F4KN69 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.|||An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.|||Belongs to the DTD family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/879243:PORAS_RS08410 ^@ http://purl.uniprot.org/uniprot/F4KJJ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS03220 ^@ http://purl.uniprot.org/uniprot/F4KJG0 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/879243:PORAS_RS06060 ^@ http://purl.uniprot.org/uniprot/F4KLR8 ^@ Similarity ^@ Belongs to the V-ATPase D subunit family. http://togogenome.org/gene/879243:PORAS_RS00935 ^@ http://purl.uniprot.org/uniprot/F4KLN5 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/879243:PORAS_RS06020 ^@ http://purl.uniprot.org/uniprot/F4KLR0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS00995 ^@ http://purl.uniprot.org/uniprot/F4KLW6 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/879243:PORAS_RS02420 ^@ http://purl.uniprot.org/uniprot/F4KNI0 ^@ Function|||Similarity ^@ Belongs to the peptidase S46 family.|||Catalyzes the removal of dipeptides from the N-terminus of oligopeptides. http://togogenome.org/gene/879243:PORAS_RS08320 ^@ http://purl.uniprot.org/uniprot/F4KJI0 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/879243:PORAS_RS02520 ^@ http://purl.uniprot.org/uniprot/F4KNJ9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS01685 ^@ http://purl.uniprot.org/uniprot/F4KMP6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/879243:PORAS_RS03935 ^@ http://purl.uniprot.org/uniprot/F4KK07 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family. http://togogenome.org/gene/879243:PORAS_RS06575 ^@ http://purl.uniprot.org/uniprot/F4KM87 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS02270 ^@ http://purl.uniprot.org/uniprot/F4KN80 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/879243:PORAS_RS07370 ^@ http://purl.uniprot.org/uniprot/F4KNA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmI family.|||Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS01050 ^@ http://purl.uniprot.org/uniprot/F4KLX8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. Biotin synthase family.|||Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS07405 ^@ http://purl.uniprot.org/uniprot/F4KNA7 ^@ Caution|||Function|||Similarity ^@ Belongs to the DXR family.|||Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS04830 ^@ http://purl.uniprot.org/uniprot/F4KKI5 ^@ Similarity ^@ Belongs to the bacterial sugar transferase family. http://togogenome.org/gene/879243:PORAS_RS02620 ^@ http://purl.uniprot.org/uniprot/F4KNT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta sliding clamp family.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS00320 ^@ http://purl.uniprot.org/uniprot/F4KL46 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/879243:PORAS_RS06130 ^@ http://purl.uniprot.org/uniprot/F4KLT1 ^@ Similarity ^@ Belongs to the ComB family. http://togogenome.org/gene/879243:PORAS_RS01800 ^@ http://purl.uniprot.org/uniprot/F4KMR9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/879243:PORAS_RS07745 ^@ http://purl.uniprot.org/uniprot/F4KNN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferritin family. Prokaryotic subfamily.|||Cytoplasm|||Iron-storage protein. http://togogenome.org/gene/879243:PORAS_RS08425 ^@ http://purl.uniprot.org/uniprot/F4KJK1 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/879243:PORAS_RS02515 ^@ http://purl.uniprot.org/uniprot/F4KNJ8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS05280 ^@ http://purl.uniprot.org/uniprot/F4KKZ1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/879243:PORAS_RS02075 ^@ http://purl.uniprot.org/uniprot/F4KN40 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/879243:PORAS_RS01410 ^@ http://purl.uniprot.org/uniprot/F4KMC1 ^@ Similarity ^@ Belongs to the bacteroidetes fimbrillin superfamily. FimB/Mfa2 family. http://togogenome.org/gene/879243:PORAS_RS05160 ^@ http://purl.uniprot.org/uniprot/F4KKQ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.|||Cytoplasm|||Homodimer.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/879243:PORAS_RS06685 ^@ http://purl.uniprot.org/uniprot/F4KMH9 ^@ Similarity ^@ Belongs to the acetyl-CoA hydrolase/transferase family. http://togogenome.org/gene/879243:PORAS_RS01265 ^@ http://purl.uniprot.org/uniprot/F4KM23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS04475 ^@ http://purl.uniprot.org/uniprot/F4KKB6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||Cytoplasm|||Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/879243:PORAS_RS01755 ^@ http://purl.uniprot.org/uniprot/F4KMR0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/879243:PORAS_RS01920 ^@ http://purl.uniprot.org/uniprot/F4KMU5 ^@ Similarity ^@ Belongs to the OMP decarboxylase family. Type 2 subfamily. http://togogenome.org/gene/879243:PORAS_RS03365 ^@ http://purl.uniprot.org/uniprot/F4KJQ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS02725 ^@ http://purl.uniprot.org/uniprot/F4KNV2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase D family. Cardiolipin synthase subfamily.|||Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.|||Cell inner membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS00085 ^@ http://purl.uniprot.org/uniprot/F4KKT9 ^@ Caution|||Domain|||Function|||Miscellaneous|||Similarity ^@ Belongs to the CobB/CbiA family.|||Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.|||Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate. http://togogenome.org/gene/879243:PORAS_RS04510 ^@ http://purl.uniprot.org/uniprot/F4KKC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/879243:PORAS_RS00270 ^@ http://purl.uniprot.org/uniprot/F4KKX7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/879243:PORAS_RS08065 ^@ http://purl.uniprot.org/uniprot/F4KP22 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvC family.|||Binds 2 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA. http://togogenome.org/gene/879243:PORAS_RS06155 ^@ http://purl.uniprot.org/uniprot/F4KLT5 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS07040 ^@ http://purl.uniprot.org/uniprot/F4KMW8 ^@ Caution|||Function|||Similarity ^@ Belongs to the dUTPase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/879243:PORAS_RS02130 ^@ http://purl.uniprot.org/uniprot/F4KN51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TsaE family.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS01235 ^@ http://purl.uniprot.org/uniprot/F4KM16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/879243:PORAS_RS02650 ^@ http://purl.uniprot.org/uniprot/F4KNT8 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/879243:PORAS_RS01115 ^@ http://purl.uniprot.org/uniprot/F4KLZ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecX family.|||Cytoplasm|||Modulates RecA activity. http://togogenome.org/gene/879243:PORAS_RS01045 ^@ http://purl.uniprot.org/uniprot/F4KLX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Membrane http://togogenome.org/gene/879243:PORAS_RS07035 ^@ http://purl.uniprot.org/uniprot/F4KMW7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspG family.|||Binds 1 [4Fe-4S] cluster.|||Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. http://togogenome.org/gene/879243:PORAS_RS02475 ^@ http://purl.uniprot.org/uniprot/F4KNJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transaldolase family. Type 3B subfamily.|||Cytoplasm|||Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. http://togogenome.org/gene/879243:PORAS_RS06805 ^@ http://purl.uniprot.org/uniprot/F4KMK3 ^@ Function|||Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/879243:PORAS_RS06555 ^@ http://purl.uniprot.org/uniprot/F4KM83 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/879243:PORAS_RS06760 ^@ http://purl.uniprot.org/uniprot/F4KMJ4 ^@ Function|||Similarity ^@ Belongs to the alanine racemase family.|||Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. http://togogenome.org/gene/879243:PORAS_RS00925 ^@ http://purl.uniprot.org/uniprot/F4KLN3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/879243:PORAS_RS04585 ^@ http://purl.uniprot.org/uniprot/F4KKD7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/879243:PORAS_RS00960 ^@ http://purl.uniprot.org/uniprot/F4KLV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.|||Cell inner membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.|||Membrane http://togogenome.org/gene/879243:PORAS_RS07795 ^@ http://purl.uniprot.org/uniprot/F4KNP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB family.|||Cell inner membrane http://togogenome.org/gene/879243:PORAS_RS08180 ^@ http://purl.uniprot.org/uniprot/F4KP45 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.|||Binds 1 potassium ion per subunit.|||Cytoplasm|||Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS06070 ^@ http://purl.uniprot.org/uniprot/F4KLS0 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. http://togogenome.org/gene/879243:PORAS_RS08285 ^@ http://purl.uniprot.org/uniprot/F4KJH2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/879243:PORAS_RS03555 ^@ http://purl.uniprot.org/uniprot/F4KJT7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/879243:PORAS_RS02930 ^@ http://purl.uniprot.org/uniprot/F4KJA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB family.|||Cell inner membrane http://togogenome.org/gene/879243:PORAS_RS02750 ^@ http://purl.uniprot.org/uniprot/F4KNV8 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/879243:PORAS_RS01485 ^@ http://purl.uniprot.org/uniprot/F4KMD5 ^@ Caution|||Function|||Similarity ^@ Belongs to the GART family.|||Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS06260 ^@ http://purl.uniprot.org/uniprot/F4KLV6 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvB family.|||Cytoplasm|||Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.|||Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA. http://togogenome.org/gene/879243:PORAS_RS06390 ^@ http://purl.uniprot.org/uniprot/F4KM51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylate kinase family.|||Cytoplasm|||Essential for recycling GMP and indirectly, cGMP. http://togogenome.org/gene/879243:PORAS_RS05545 ^@ http://purl.uniprot.org/uniprot/F4KL37 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/879243:PORAS_RS03700 ^@ http://purl.uniprot.org/uniprot/F4KJW6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell inner membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. http://togogenome.org/gene/879243:PORAS_RS06065 ^@ http://purl.uniprot.org/uniprot/F4KLR9 ^@ Similarity ^@ Belongs to the ATPase alpha/beta chains family. http://togogenome.org/gene/879243:PORAS_RS03235 ^@ http://purl.uniprot.org/uniprot/F4KJG3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RnfG family.|||Cell inner membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/879243:PORAS_RS03940 ^@ http://purl.uniprot.org/uniprot/F4KK08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the etk/wzc family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS05040 ^@ http://purl.uniprot.org/uniprot/F4KKM8 ^@ Similarity ^@ Belongs to the DapB family. http://togogenome.org/gene/879243:PORAS_RS02240 ^@ http://purl.uniprot.org/uniprot/F4KN74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS07120 ^@ http://purl.uniprot.org/uniprot/F4KMY4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferrochelatase family.|||Catalyzes the ferrous insertion into protoporphyrin IX.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS01760 ^@ http://purl.uniprot.org/uniprot/F4KMR1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/879243:PORAS_RS08280 ^@ http://purl.uniprot.org/uniprot/F4KJH1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/879243:PORAS_RS08370 ^@ http://purl.uniprot.org/uniprot/F4KJJ0 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. http://togogenome.org/gene/879243:PORAS_RS03115 ^@ http://purl.uniprot.org/uniprot/F4KJE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/879243:PORAS_RS05660 ^@ http://purl.uniprot.org/uniprot/F4KLC5 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/879243:PORAS_RS02360 ^@ http://purl.uniprot.org/uniprot/F4KNG7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS05370 ^@ http://purl.uniprot.org/uniprot/F4KL04 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/879243:PORAS_RS00360 ^@ http://purl.uniprot.org/uniprot/F4KL54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome ubiquinol oxidase subunit 2 family.|||Membrane http://togogenome.org/gene/879243:PORAS_RS04855 ^@ http://purl.uniprot.org/uniprot/F4KKJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/879243:PORAS_RS07170 ^@ http://purl.uniprot.org/uniprot/F4KMZ5 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/879243:PORAS_RS05785 ^@ http://purl.uniprot.org/uniprot/F4KLF1 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/879243:PORAS_RS05975 ^@ http://purl.uniprot.org/uniprot/F4KLQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS00835 ^@ http://purl.uniprot.org/uniprot/F4KLL5 ^@ Similarity ^@ Belongs to the peptidase C25 family. http://togogenome.org/gene/879243:PORAS_RS01785 ^@ http://purl.uniprot.org/uniprot/F4KMR6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/879243:PORAS_RS07130 ^@ http://purl.uniprot.org/uniprot/F4KMY6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/879243:PORAS_RS07320 ^@ http://purl.uniprot.org/uniprot/F4KN90 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.|||In the N-terminal section; belongs to the malic enzymes family. http://togogenome.org/gene/879243:PORAS_RS01105 ^@ http://purl.uniprot.org/uniprot/F4KLY9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of glycine to tRNA(Gly).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/879243:PORAS_RS01435 ^@ http://purl.uniprot.org/uniprot/F4KMC6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/879243:PORAS_RS07975 ^@ http://purl.uniprot.org/uniprot/F4KP04 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS03480 ^@ http://purl.uniprot.org/uniprot/F4KJS5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/879243:PORAS_RS05430 ^@ http://purl.uniprot.org/uniprot/F4KL16 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S41B family.|||Cytoplasm|||Degrades oligopeptides. http://togogenome.org/gene/879243:PORAS_RS04735 ^@ http://purl.uniprot.org/uniprot/F4KKG6 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/879243:PORAS_RS05765 ^@ http://purl.uniprot.org/uniprot/F4KLE7 ^@ Similarity ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. http://togogenome.org/gene/879243:PORAS_RS08100 ^@ http://purl.uniprot.org/uniprot/F4KP29 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A monovalent cation. Ammonium or potassium.|||Belongs to the type III pantothenate kinase family.|||Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/879243:PORAS_RS02210 ^@ http://purl.uniprot.org/uniprot/F4KN68 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrC family.|||Cytoplasm|||Interacts with UvrB in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. http://togogenome.org/gene/879243:PORAS_RS01220 ^@ http://purl.uniprot.org/uniprot/F4KM13 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/879243:PORAS_RS00900 ^@ http://purl.uniprot.org/uniprot/F4KLM8 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/879243:PORAS_RS05100 ^@ http://purl.uniprot.org/uniprot/F4KKP2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS06905 ^@ http://purl.uniprot.org/uniprot/F4KMM1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS02680 ^@ http://purl.uniprot.org/uniprot/F4KNU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CoaE family.|||Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS07485 ^@ http://purl.uniprot.org/uniprot/F4KNC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurF subfamily.|||Cytoplasm|||Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. http://togogenome.org/gene/879243:PORAS_RS08120 ^@ http://purl.uniprot.org/uniprot/F4KP33 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS03995 ^@ http://purl.uniprot.org/uniprot/F4KK21 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS06365 ^@ http://purl.uniprot.org/uniprot/F4KM46 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/879243:PORAS_RS03300 ^@ http://purl.uniprot.org/uniprot/F4KJP1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/879243:PORAS_RS08570 ^@ http://purl.uniprot.org/uniprot/F4KJU6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS03855 ^@ http://purl.uniprot.org/uniprot/F4KJZ3 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/879243:PORAS_RS08235 ^@ http://purl.uniprot.org/uniprot/F4KP55 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase Z family.|||Binds 2 Zn(2+) ions.|||Homodimer.|||Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. http://togogenome.org/gene/879243:PORAS_RS05655 ^@ http://purl.uniprot.org/uniprot/F4KLC4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit.|||Binds 2 divalent ions per subunit.|||Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.|||Cytoplasm|||Homotetramer; dimer of dimers. http://togogenome.org/gene/879243:PORAS_RS03245 ^@ http://purl.uniprot.org/uniprot/F4KJN1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.|||Binds 2 [4Fe-4S] clusters per subunit.|||Cell inner membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/879243:PORAS_RS03560 ^@ http://purl.uniprot.org/uniprot/F4KJT8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/879243:PORAS_RS01955 ^@ http://purl.uniprot.org/uniprot/F4KN15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyribonucleotide nucleotidyltransferase family.|||Cytoplasm|||Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. http://togogenome.org/gene/879243:PORAS_RS03335 ^@ http://purl.uniprot.org/uniprot/F4KJP8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.|||Cell inner membrane|||Membrane|||Probable transporter of a GTP-driven Fe(2+) uptake system. http://togogenome.org/gene/879243:PORAS_RS01720 ^@ http://purl.uniprot.org/uniprot/F4KMQ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/879243:PORAS_RS01715 ^@ http://purl.uniprot.org/uniprot/F4KMQ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell inner membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/879243:PORAS_RS03360 ^@ http://purl.uniprot.org/uniprot/F4KJQ3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS00825 ^@ http://purl.uniprot.org/uniprot/F4KLL3 ^@ Similarity ^@ Belongs to the SusD family. http://togogenome.org/gene/879243:PORAS_RS05780 ^@ http://purl.uniprot.org/uniprot/F4KLF0 ^@ Similarity ^@ Belongs to the peptidase C25 family. http://togogenome.org/gene/879243:PORAS_RS05845 ^@ http://purl.uniprot.org/uniprot/F4KLG3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the methylaspartate mutase GlmE subunit family.|||Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).|||Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS01890 ^@ http://purl.uniprot.org/uniprot/F4KMU0 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/879243:PORAS_RS01590 ^@ http://purl.uniprot.org/uniprot/F4KMF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAE transporter (TC 2.A.81) family.|||Cell membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS01225 ^@ http://purl.uniprot.org/uniprot/F4KM14 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.|||Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS06545 ^@ http://purl.uniprot.org/uniprot/F4KM81 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-3 family.|||Cytoplasm|||IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.|||Monomer. http://togogenome.org/gene/879243:PORAS_RS02080 ^@ http://purl.uniprot.org/uniprot/F4KN41 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/879243:PORAS_RS04890 ^@ http://purl.uniprot.org/uniprot/F4KKJ7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).|||Homodimer. http://togogenome.org/gene/879243:PORAS_RS02830 ^@ http://purl.uniprot.org/uniprot/F4KNX6 ^@ Similarity ^@ Belongs to the 3-oxoacid CoA-transferase subunit B family. http://togogenome.org/gene/879243:PORAS_RS01770 ^@ http://purl.uniprot.org/uniprot/F4KMR3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/879243:PORAS_RS04415 ^@ http://purl.uniprot.org/uniprot/F4KKA3 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS01540 ^@ http://purl.uniprot.org/uniprot/F4KME9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.|||Cytoplasm|||In the C-terminal section; belongs to the helicase family. RecG subfamily.|||In the N-terminal section; belongs to the UvrB family. http://togogenome.org/gene/879243:PORAS_RS00970 ^@ http://purl.uniprot.org/uniprot/F4KLW1 ^@ Function|||Similarity ^@ Belongs to the CobB/CobQ family. CobQ subfamily.|||Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. http://togogenome.org/gene/879243:PORAS_RS06980 ^@ http://purl.uniprot.org/uniprot/F4KMV8 ^@ Function|||Similarity ^@ Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.|||Belongs to the organic radical-activating enzymes family. http://togogenome.org/gene/879243:PORAS_RS01310 ^@ http://purl.uniprot.org/uniprot/F4KMA0 ^@ Function|||Similarity ^@ Belongs to the NadC/ModD family.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/879243:PORAS_RS03330 ^@ http://purl.uniprot.org/uniprot/F4KJP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS01895 ^@ http://purl.uniprot.org/uniprot/F4KMU1 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/879243:PORAS_RS03585 ^@ http://purl.uniprot.org/uniprot/F4KJU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YqgF HJR family.|||Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS01165 ^@ http://purl.uniprot.org/uniprot/F4KM02 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. http://togogenome.org/gene/879243:PORAS_RS06000 ^@ http://purl.uniprot.org/uniprot/F4KLQ6 ^@ Caution|||Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.|||Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS00820 ^@ http://purl.uniprot.org/uniprot/F4KLL2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NqrA family.|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. http://togogenome.org/gene/879243:PORAS_RS01730 ^@ http://purl.uniprot.org/uniprot/F4KMQ5 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/879243:PORAS_RS04410 ^@ http://purl.uniprot.org/uniprot/F4KKA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/879243:PORAS_RS01505 ^@ http://purl.uniprot.org/uniprot/F4KME1 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/879243:PORAS_RS00810 ^@ http://purl.uniprot.org/uniprot/F4KLL0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrC family.|||Cell inner membrane|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. http://togogenome.org/gene/879243:PORAS_RS02835 ^@ http://purl.uniprot.org/uniprot/F4KNX7 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/879243:PORAS_RS02690 ^@ http://purl.uniprot.org/uniprot/F4KNU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YajC family.|||Membrane http://togogenome.org/gene/879243:PORAS_RS01095 ^@ http://purl.uniprot.org/uniprot/F4KLY7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/879243:PORAS_RS01160 ^@ http://purl.uniprot.org/uniprot/F4KM01 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/879243:PORAS_RS03810 ^@ http://purl.uniprot.org/uniprot/F4KJY4 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/879243:PORAS_RS05190 ^@ http://purl.uniprot.org/uniprot/F4KKR0 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/879243:PORAS_RS05800 ^@ http://purl.uniprot.org/uniprot/F4KLF4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer.|||In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.|||In the N-terminal section; belongs to the MIP18 family. http://togogenome.org/gene/879243:PORAS_RS00180 ^@ http://purl.uniprot.org/uniprot/F4KKV9 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/879243:PORAS_RS06870 ^@ http://purl.uniprot.org/uniprot/F4KML5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.|||Cell membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS02165 ^@ http://purl.uniprot.org/uniprot/F4KN58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS01070 ^@ http://purl.uniprot.org/uniprot/F4KLY2 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/879243:PORAS_RS04985 ^@ http://purl.uniprot.org/uniprot/F4KKL7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ThiC family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. http://togogenome.org/gene/879243:PORAS_RS05630 ^@ http://purl.uniprot.org/uniprot/F4KLB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0410 family.|||Membrane http://togogenome.org/gene/879243:PORAS_RS08000 ^@ http://purl.uniprot.org/uniprot/F4KP09 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the pyridoxamine 5'-phosphate oxidase family.|||Binds 1 FMN per subunit.|||Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).|||Homodimer. http://togogenome.org/gene/879243:PORAS_RS00800 ^@ http://purl.uniprot.org/uniprot/F4KLK8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell inner membrane|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||Membrane|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. http://togogenome.org/gene/879243:PORAS_RS07775 ^@ http://purl.uniprot.org/uniprot/F4KNP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/879243:PORAS_RS02230 ^@ http://purl.uniprot.org/uniprot/F4KN72 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/879243:PORAS_RS06580 ^@ http://purl.uniprot.org/uniprot/F4KM88 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/879243:PORAS_RS04715 ^@ http://purl.uniprot.org/uniprot/F4KKG2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.|||Binds 1 Mn(2+) ion per subunit.|||Cytoplasm|||Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. http://togogenome.org/gene/879243:PORAS_RS02120 ^@ http://purl.uniprot.org/uniprot/F4KN49 ^@ Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.|||Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. http://togogenome.org/gene/879243:PORAS_RS06800 ^@ http://purl.uniprot.org/uniprot/F4KMK2 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/879243:PORAS_RS03120 ^@ http://purl.uniprot.org/uniprot/F4KJE1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the adenylate cyclase family. DacA/CdaA subfamily.|||Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Probably a homodimer. http://togogenome.org/gene/879243:PORAS_RS06495 ^@ http://purl.uniprot.org/uniprot/F4KM72 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS03975 ^@ http://purl.uniprot.org/uniprot/F4KK17 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseB family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/879243:PORAS_RS00125 ^@ http://purl.uniprot.org/uniprot/F4KKU8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS05135 ^@ http://purl.uniprot.org/uniprot/F4KKP9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/879243:PORAS_RS06995 ^@ http://purl.uniprot.org/uniprot/F4KMW0 ^@ Similarity ^@ Belongs to the formate--tetrahydrofolate ligase family. http://togogenome.org/gene/879243:PORAS_RS06470 ^@ http://purl.uniprot.org/uniprot/F4KM67 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family. MurG subfamily.|||Cell inner membrane|||Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS00955 ^@ http://purl.uniprot.org/uniprot/F4KLV8 ^@ Similarity ^@ Belongs to the CobT family. http://togogenome.org/gene/879243:PORAS_RS01940 ^@ http://purl.uniprot.org/uniprot/F4KMU9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Belongs to the NnrE/AIBP family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Homotetramer.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS02630 ^@ http://purl.uniprot.org/uniprot/F4KNT4 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS00720 ^@ http://purl.uniprot.org/uniprot/F4KLJ3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/879243:PORAS_RS04885 ^@ http://purl.uniprot.org/uniprot/F4KKJ6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/879243:PORAS_RS00760 ^@ http://purl.uniprot.org/uniprot/F4KLK0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS02470 ^@ http://purl.uniprot.org/uniprot/F4KNI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS06540 ^@ http://purl.uniprot.org/uniprot/F4KM80 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS07410 ^@ http://purl.uniprot.org/uniprot/F4KNA8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.|||Belongs to the RimM family.|||Binds ribosomal protein uS19.|||Cytoplasm|||The PRC barrel domain binds ribosomal protein uS19. http://togogenome.org/gene/879243:PORAS_RS06220 ^@ http://purl.uniprot.org/uniprot/F4KLU8 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/879243:PORAS_RS01620 ^@ http://purl.uniprot.org/uniprot/F4KMN3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS00395 ^@ http://purl.uniprot.org/uniprot/F4KL61 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LuxS family.|||Homodimer.|||Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). http://togogenome.org/gene/879243:PORAS_RS04575 ^@ http://purl.uniprot.org/uniprot/F4KKD5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/879243:PORAS_RS00450 ^@ http://purl.uniprot.org/uniprot/F4KL71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A8 family.|||Cell inner membrane|||This protein specifically catalyzes the removal of signal peptides from prolipoproteins. http://togogenome.org/gene/879243:PORAS_RS02910 ^@ http://purl.uniprot.org/uniprot/F4KNZ2 ^@ Subcellular Location Annotation ^@ Cell outer membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS01980 ^@ http://purl.uniprot.org/uniprot/F4KN20 ^@ Similarity ^@ Belongs to the peptidase C25 family. http://togogenome.org/gene/879243:PORAS_RS02115 ^@ http://purl.uniprot.org/uniprot/F4KN48 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.|||Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS02335 ^@ http://purl.uniprot.org/uniprot/F4KNG1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP synthase family.|||Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.|||Cytoplasm|||Homooctamer; tetramer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS08385 ^@ http://purl.uniprot.org/uniprot/F4KJJ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS03820 ^@ http://purl.uniprot.org/uniprot/F4KJY6 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/879243:PORAS_RS04155 ^@ http://purl.uniprot.org/uniprot/F4KK53 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ClpA/ClpB family.|||Cytoplasm|||Homohexamer. The oligomerization is ATP-dependent.|||Homohexamer; The oligomerization is ATP-dependent.|||Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. http://togogenome.org/gene/879243:PORAS_RS03055 ^@ http://purl.uniprot.org/uniprot/F4KJC7 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/879243:PORAS_RS00060 ^@ http://purl.uniprot.org/uniprot/F4KKT4 ^@ Similarity ^@ Belongs to the CobH/CbiC family. http://togogenome.org/gene/879243:PORAS_RS00155 ^@ http://purl.uniprot.org/uniprot/F4KKV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS03650 ^@ http://purl.uniprot.org/uniprot/F4KJV5 ^@ Similarity ^@ Belongs to the peptidase C25 family. http://togogenome.org/gene/879243:PORAS_RS08150 ^@ http://purl.uniprot.org/uniprot/F4KP39 ^@ Similarity ^@ Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. http://togogenome.org/gene/879243:PORAS_RS05670 ^@ http://purl.uniprot.org/uniprot/F4KLC8 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS01455 ^@ http://purl.uniprot.org/uniprot/F4KMD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uridine kinase family.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS07790 ^@ http://purl.uniprot.org/uniprot/F4KNP5 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/879243:PORAS_RS01375 ^@ http://purl.uniprot.org/uniprot/F4KMB4 ^@ Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. http://togogenome.org/gene/879243:PORAS_RS03230 ^@ http://purl.uniprot.org/uniprot/F4KJG2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell inner membrane|||Membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/879243:PORAS_RS00195 ^@ http://purl.uniprot.org/uniprot/F4KKW2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerC subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/879243:PORAS_RS08555 ^@ http://purl.uniprot.org/uniprot/F4KJM7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Binds 1 pyridoxal phosphate per subunit.|||Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS06300 ^@ http://purl.uniprot.org/uniprot/F4KM33 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with bS18 to 16S ribosomal RNA. http://togogenome.org/gene/879243:PORAS_RS04740 ^@ http://purl.uniprot.org/uniprot/F4KKG7 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/879243:PORAS_RS02395 ^@ http://purl.uniprot.org/uniprot/F4KNH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/879243:PORAS_RS04425 ^@ http://purl.uniprot.org/uniprot/F4KKA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Membrane http://togogenome.org/gene/879243:PORAS_RS07425 ^@ http://purl.uniprot.org/uniprot/F4KNB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI family.|||Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS07025 ^@ http://purl.uniprot.org/uniprot/F4KMW5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/879243:PORAS_RS07810 ^@ http://purl.uniprot.org/uniprot/F4KNP9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/879243:PORAS_RS01740 ^@ http://purl.uniprot.org/uniprot/F4KMQ7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/879243:PORAS_RS01705 ^@ http://purl.uniprot.org/uniprot/F4KMQ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/879243:PORAS_RS00090 ^@ http://purl.uniprot.org/uniprot/F4KKU0 ^@ Function|||Similarity ^@ Belongs to the CbiD family.|||Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. http://togogenome.org/gene/879243:PORAS_RS06430 ^@ http://purl.uniprot.org/uniprot/F4KM59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0324 family.|||Membrane http://togogenome.org/gene/879243:PORAS_RS07995 ^@ http://purl.uniprot.org/uniprot/F4KP08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Membrane http://togogenome.org/gene/879243:PORAS_RS06570 ^@ http://purl.uniprot.org/uniprot/F4KM86 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/879243:PORAS_RS03225 ^@ http://purl.uniprot.org/uniprot/F4KJG1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell inner membrane|||Membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/879243:PORAS_RS02755 ^@ http://purl.uniprot.org/uniprot/F4KNV9 ^@ Similarity ^@ Belongs to the bacterial sugar transferase family. http://togogenome.org/gene/879243:PORAS_RS03675 ^@ http://purl.uniprot.org/uniprot/F4KJW1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/879243:PORAS_RS07805 ^@ http://purl.uniprot.org/uniprot/F4KNP8 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/879243:PORAS_RS02050 ^@ http://purl.uniprot.org/uniprot/F4KJD1 ^@ Similarity ^@ Belongs to the bacterial reverse transcriptase family. http://togogenome.org/gene/879243:PORAS_RS07275 ^@ http://purl.uniprot.org/uniprot/F4KN81 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/879243:PORAS_RS01350 ^@ http://purl.uniprot.org/uniprot/F4KMA9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shikimate kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/879243:PORAS_RS01695 ^@ http://purl.uniprot.org/uniprot/F4KMP8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/879243:PORAS_RS01060 ^@ http://purl.uniprot.org/uniprot/F4KLY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.|||Cytoplasm|||Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III. http://togogenome.org/gene/879243:PORAS_RS05480 ^@ http://purl.uniprot.org/uniprot/F4KL23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.|||Cell inner membrane|||Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.|||Membrane|||Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. http://togogenome.org/gene/879243:PORAS_RS00220 ^@ http://purl.uniprot.org/uniprot/F4KKW7 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/879243:PORAS_RS01055 ^@ http://purl.uniprot.org/uniprot/F4KLX9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.|||Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/879243:PORAS_RS02555 ^@ http://purl.uniprot.org/uniprot/F4KNK6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methylmalonyl-CoA mutase family.|||Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates.|||Heterodimer of an alpha and a beta chain. http://togogenome.org/gene/879243:PORAS_RS05900 ^@ http://purl.uniprot.org/uniprot/F4KLH4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS05620 ^@ http://purl.uniprot.org/uniprot/F4KLB6 ^@ Function|||Similarity ^@ Belongs to the relA/spoT family.|||In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. http://togogenome.org/gene/879243:PORAS_RS07930 ^@ http://purl.uniprot.org/uniprot/F4KNZ5 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pantothenate synthetase family.|||Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.|||Cytoplasm|||Homodimer.|||The reaction proceeds by a bi uni uni bi ping pong mechanism. http://togogenome.org/gene/879243:PORAS_RS02275 ^@ http://purl.uniprot.org/uniprot/F4KNE8 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/879243:PORAS_RS07350 ^@ http://purl.uniprot.org/uniprot/F4KN96 ^@ Similarity ^@ Belongs to the peptidase C25 family. http://togogenome.org/gene/879243:PORAS_RS06140 ^@ http://purl.uniprot.org/uniprot/F4KLT3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvT family.|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/879243:PORAS_RS03805 ^@ http://purl.uniprot.org/uniprot/F4KJY3 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/879243:PORAS_RS01195 ^@ http://purl.uniprot.org/uniprot/F4KM08 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/879243:PORAS_RS07440 ^@ http://purl.uniprot.org/uniprot/F4KNB4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS03205 ^@ http://purl.uniprot.org/uniprot/F4KJF7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS06050 ^@ http://purl.uniprot.org/uniprot/F4KLR6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS04680 ^@ http://purl.uniprot.org/uniprot/F4KKF5 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/879243:PORAS_RS01305 ^@ http://purl.uniprot.org/uniprot/F4KM99 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.|||Catalyzes the oxidation of L-aspartate to iminoaspartate.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS05665 ^@ http://purl.uniprot.org/uniprot/F4KLC7 ^@ Similarity ^@ Belongs to the Nth/MutY family. http://togogenome.org/gene/879243:PORAS_RS08210 ^@ http://purl.uniprot.org/uniprot/F4KP51 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS02585 ^@ http://purl.uniprot.org/uniprot/F4KNS5 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS04015 ^@ http://purl.uniprot.org/uniprot/F4KK25 ^@ Similarity ^@ Belongs to the ParB family. http://togogenome.org/gene/879243:PORAS_RS01830 ^@ http://purl.uniprot.org/uniprot/F4KMS5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/879243:PORAS_RS01645 ^@ http://purl.uniprot.org/uniprot/F4KMN8 ^@ Similarity ^@ Belongs to the beta-eliminating lyase family. http://togogenome.org/gene/879243:PORAS_RS05740 ^@ http://purl.uniprot.org/uniprot/F4KLE2 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/879243:PORAS_RS04405 ^@ http://purl.uniprot.org/uniprot/F4KKA1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/879243:PORAS_RS00880 ^@ http://purl.uniprot.org/uniprot/F4KLM4 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). http://togogenome.org/gene/879243:PORAS_RS04705 ^@ http://purl.uniprot.org/uniprot/F4KKG0 ^@ Function ^@ The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. http://togogenome.org/gene/879243:PORAS_RS05885 ^@ http://purl.uniprot.org/uniprot/F4KLH1 ^@ Cofactor ^@ Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/879243:PORAS_RS05420 ^@ http://purl.uniprot.org/uniprot/F4KL14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/879243:PORAS_RS06195 ^@ http://purl.uniprot.org/uniprot/F4KLU3 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/879243:PORAS_RS06310 ^@ http://purl.uniprot.org/uniprot/F4KM35 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/879243:PORAS_RS06290 ^@ http://purl.uniprot.org/uniprot/F4KM31 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/879243:PORAS_RS06745 ^@ http://purl.uniprot.org/uniprot/F4KMJ1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. HutI family.|||Binds 1 zinc or iron ion per subunit.|||Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS06420 ^@ http://purl.uniprot.org/uniprot/F4KM57 ^@ Similarity ^@ Belongs to the peptidase C69 family. http://togogenome.org/gene/879243:PORAS_RS06185 ^@ http://purl.uniprot.org/uniprot/F4KLU1 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase class-2 family.|||Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. http://togogenome.org/gene/879243:PORAS_RS01725 ^@ http://purl.uniprot.org/uniprot/F4KMQ4 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/879243:PORAS_RS01775 ^@ http://purl.uniprot.org/uniprot/F4KMR4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/879243:PORAS_RS08020 ^@ http://purl.uniprot.org/uniprot/F4KP13 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/879243:PORAS_RS03990 ^@ http://purl.uniprot.org/uniprot/F4KK20 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/879243:PORAS_RS00975 ^@ http://purl.uniprot.org/uniprot/F4KLW2 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/879243:PORAS_RS01020 ^@ http://purl.uniprot.org/uniprot/F4KLX1 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/879243:PORAS_RS03985 ^@ http://purl.uniprot.org/uniprot/F4KK19 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/879243:PORAS_RS06515 ^@ http://purl.uniprot.org/uniprot/F4KM76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecF family.|||Cytoplasm|||The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. http://togogenome.org/gene/879243:PORAS_RS03665 ^@ http://purl.uniprot.org/uniprot/F4KJV9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/879243:PORAS_RS02955 ^@ http://purl.uniprot.org/uniprot/F4KJB3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ApbE family.|||Cell inner membrane|||Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.|||Magnesium. Can also use manganese. http://togogenome.org/gene/879243:PORAS_RS06255 ^@ http://purl.uniprot.org/uniprot/F4KLV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XseA family.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS04395 ^@ http://purl.uniprot.org/uniprot/F4KK99 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RlmN family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.|||Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. http://togogenome.org/gene/879243:PORAS_RS01710 ^@ http://purl.uniprot.org/uniprot/F4KMQ1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/879243:PORAS_RS07030 ^@ http://purl.uniprot.org/uniprot/F4KMW6 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/879243:PORAS_RS06295 ^@ http://purl.uniprot.org/uniprot/F4KM32 ^@ Similarity ^@ Belongs to the PstS family. http://togogenome.org/gene/879243:PORAS_RS03370 ^@ http://purl.uniprot.org/uniprot/F4KJQ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS03470 ^@ http://purl.uniprot.org/uniprot/F4KJS3 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family. http://togogenome.org/gene/879243:PORAS_RS09090 ^@ http://purl.uniprot.org/uniprot/F4KKK8 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/879243:PORAS_RS01230 ^@ http://purl.uniprot.org/uniprot/F4KM15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.|||Cell inner membrane|||Mediates zinc uptake. May also transport other divalent cations.|||Membrane http://togogenome.org/gene/879243:PORAS_RS07830 ^@ http://purl.uniprot.org/uniprot/F4KNQ3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CutC family.|||Cytoplasm|||Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case. http://togogenome.org/gene/879243:PORAS_RS06225 ^@ http://purl.uniprot.org/uniprot/F4KLU9 ^@ Similarity ^@ Belongs to the pyruvoyl-dependent arginine decarboxylase family. http://togogenome.org/gene/879243:PORAS_RS03405 ^@ http://purl.uniprot.org/uniprot/F4KJR1 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/879243:PORAS_RS07085 ^@ http://purl.uniprot.org/uniprot/F4KMX7 ^@ Similarity ^@ Belongs to the EPSP synthase family. http://togogenome.org/gene/879243:PORAS_RS01065 ^@ http://purl.uniprot.org/uniprot/F4KLY1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/879243:PORAS_RS05675 ^@ http://purl.uniprot.org/uniprot/F4KLC9 ^@ Similarity ^@ Belongs to the UPF0758 family. http://togogenome.org/gene/879243:PORAS_RS03170 ^@ http://purl.uniprot.org/uniprot/F4KJF1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase RlmH family.|||Cytoplasm|||Homodimer.|||Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. http://togogenome.org/gene/879243:PORAS_RS04320 ^@ http://purl.uniprot.org/uniprot/F4KK84 ^@ Similarity ^@ Belongs to the peptidase C25 family. http://togogenome.org/gene/879243:PORAS_RS04905 ^@ http://purl.uniprot.org/uniprot/F4KKK0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/879243:PORAS_RS03355 ^@ http://purl.uniprot.org/uniprot/F4KJQ2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family. DXPS subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).|||Homodimer. http://togogenome.org/gene/879243:PORAS_RS05605 ^@ http://purl.uniprot.org/uniprot/F4KLB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell inner membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Membrane|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/879243:PORAS_RS04030 ^@ http://purl.uniprot.org/uniprot/F4KK28 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/879243:PORAS_RS05070 ^@ http://purl.uniprot.org/uniprot/F4KKN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS06560 ^@ http://purl.uniprot.org/uniprot/F4KM84 ^@ Function|||Similarity ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate. http://togogenome.org/gene/879243:PORAS_RS04665 ^@ http://purl.uniprot.org/uniprot/F4KKF2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS05265 ^@ http://purl.uniprot.org/uniprot/F4KKY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/879243:PORAS_RS00465 ^@ http://purl.uniprot.org/uniprot/F4KL74 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS08550 ^@ http://purl.uniprot.org/uniprot/F4KJM6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.|||Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS03815 ^@ http://purl.uniprot.org/uniprot/F4KJY5 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/879243:PORAS_RS05560 ^@ http://purl.uniprot.org/uniprot/F4KL40 ^@ Function|||Miscellaneous|||Similarity ^@ Belongs to the thiamine-monophosphate kinase family.|||Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.|||Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. http://togogenome.org/gene/879243:PORAS_RS06620 ^@ http://purl.uniprot.org/uniprot/F4KMG5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20B family.|||Binds 2 Zn(2+) ions per subunit. http://togogenome.org/gene/879243:PORAS_RS02450 ^@ http://purl.uniprot.org/uniprot/F4KNI5 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. L-methionine gamma-lyase subfamily. http://togogenome.org/gene/879243:PORAS_RS02850 ^@ http://purl.uniprot.org/uniprot/F4KNY0 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/879243:PORAS_RS08505 ^@ http://purl.uniprot.org/uniprot/F4KJL7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS04900 ^@ http://purl.uniprot.org/uniprot/F4KKJ9 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ 2 residues (Tyr-61 and Arg-64) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.|||Belongs to the sirtuin family. Class III subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. http://togogenome.org/gene/879243:PORAS_RS03200 ^@ http://purl.uniprot.org/uniprot/F4KJF6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS06465 ^@ http://purl.uniprot.org/uniprot/F4KM66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS02435 ^@ http://purl.uniprot.org/uniprot/F4KNI2 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/879243:PORAS_RS02900 ^@ http://purl.uniprot.org/uniprot/F4KNZ0 ^@ Similarity ^@ Belongs to the asparaginase 1 family. http://togogenome.org/gene/879243:PORAS_RS01255 ^@ http://purl.uniprot.org/uniprot/F4KM21 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase H family.|||Binds 2 metal ions per subunit. Manganese or magnesium.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. http://togogenome.org/gene/879243:PORAS_RS04880 ^@ http://purl.uniprot.org/uniprot/F4KKJ5 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Homodimer. http://togogenome.org/gene/879243:PORAS_RS05270 ^@ http://purl.uniprot.org/uniprot/F4KKY9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RimP family.|||Cytoplasm|||Required for maturation of 30S ribosomal subunits. http://togogenome.org/gene/879243:PORAS_RS07415 ^@ http://purl.uniprot.org/uniprot/F4KNA9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS02925 ^@ http://purl.uniprot.org/uniprot/F4KJA8 ^@ Similarity ^@ Belongs to the BlaI transcriptional regulatory family. http://togogenome.org/gene/879243:PORAS_RS07325 ^@ http://purl.uniprot.org/uniprot/F4KN91 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. http://togogenome.org/gene/879243:PORAS_RS05580 ^@ http://purl.uniprot.org/uniprot/F4KLA8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS02035 ^@ http://purl.uniprot.org/uniprot/F4KN31 ^@ Similarity ^@ Belongs to the peptidase C25 family. http://togogenome.org/gene/879243:PORAS_RS03050 ^@ http://purl.uniprot.org/uniprot/F4KJC6 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/879243:PORAS_RS00140 ^@ http://purl.uniprot.org/uniprot/F4KKV1 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/879243:PORAS_RS04285 ^@ http://purl.uniprot.org/uniprot/F4KK78 ^@ Similarity ^@ Belongs to the bacteroidetes fimbrillin superfamily. FimB/Mfa2 family. http://togogenome.org/gene/879243:PORAS_RS07980 ^@ http://purl.uniprot.org/uniprot/F4KP05 ^@ Similarity ^@ Belongs to the NusB family. http://togogenome.org/gene/879243:PORAS_RS06030 ^@ http://purl.uniprot.org/uniprot/F4KLR2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurB family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS07760 ^@ http://purl.uniprot.org/uniprot/F4KNP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/879243:PORAS_RS00200 ^@ http://purl.uniprot.org/uniprot/F4KKW3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type-II 3-dehydroquinase family.|||Catalyzes a trans-dehydration via an enolate intermediate.|||Homododecamer. http://togogenome.org/gene/879243:PORAS_RS06010 ^@ http://purl.uniprot.org/uniprot/F4KLQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Lgt family.|||Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.|||Cell inner membrane http://togogenome.org/gene/879243:PORAS_RS01675 ^@ http://purl.uniprot.org/uniprot/F4KMP4 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/879243:PORAS_RS08530 ^@ http://purl.uniprot.org/uniprot/F4KJM2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Cytoplasm|||Homodimer.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/879243:PORAS_RS07505 ^@ http://purl.uniprot.org/uniprot/F4KNC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.|||Cell inner membrane|||Membrane|||Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. http://togogenome.org/gene/879243:PORAS_RS06360 ^@ http://purl.uniprot.org/uniprot/F4KM45 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/879243:PORAS_RS06675 ^@ http://purl.uniprot.org/uniprot/F4KMH7 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/879243:PORAS_RS03565 ^@ http://purl.uniprot.org/uniprot/F4KJT9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/879243:PORAS_RS03460 ^@ http://purl.uniprot.org/uniprot/F4KJS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers. http://togogenome.org/gene/879243:PORAS_RS00805 ^@ http://purl.uniprot.org/uniprot/F4KLK9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell inner membrane|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||Membrane|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. http://togogenome.org/gene/879243:PORAS_RS08855 ^@ http://purl.uniprot.org/uniprot/F4KLB9 ^@ Cofactor|||Similarity ^@ Belongs to the rubredoxin family.|||Binds 1 Fe(3+) ion per subunit. http://togogenome.org/gene/879243:PORAS_RS01825 ^@ http://purl.uniprot.org/uniprot/F4KMS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS00510 ^@ http://purl.uniprot.org/uniprot/F4KL83 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS08080 ^@ http://purl.uniprot.org/uniprot/F4KP25 ^@ Similarity ^@ Belongs to the peptidase C25 family. http://togogenome.org/gene/879243:PORAS_RS07765 ^@ http://purl.uniprot.org/uniprot/F4KNP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/879243:PORAS_RS06550 ^@ http://purl.uniprot.org/uniprot/F4KM82 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/879243:PORAS_RS01270 ^@ http://purl.uniprot.org/uniprot/F4KM24 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/879243:PORAS_RS01845 ^@ http://purl.uniprot.org/uniprot/F4KMS9 ^@ Similarity ^@ Belongs to the peptidase S9C family. http://togogenome.org/gene/879243:PORAS_RS01100 ^@ http://purl.uniprot.org/uniprot/F4KLY8 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/879243:PORAS_RS06015 ^@ http://purl.uniprot.org/uniprot/F4KLQ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the diaminopimelate dehydrogenase family.|||Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate.|||Homodimer. http://togogenome.org/gene/879243:PORAS_RS03180 ^@ http://purl.uniprot.org/uniprot/F4KJF3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/879243:PORAS_RS05550 ^@ http://purl.uniprot.org/uniprot/F4KL38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/879243:PORAS_RS00500 ^@ http://purl.uniprot.org/uniprot/F4KL81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS04730 ^@ http://purl.uniprot.org/uniprot/F4KKG5 ^@ Similarity ^@ Belongs to the ThrE exporter (TC 2.A.79) family. http://togogenome.org/gene/879243:PORAS_RS01150 ^@ http://purl.uniprot.org/uniprot/F4KLZ9 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/879243:PORAS_RS07075 ^@ http://purl.uniprot.org/uniprot/F4KMX5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS04365 ^@ http://purl.uniprot.org/uniprot/F4KK93 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS01445 ^@ http://purl.uniprot.org/uniprot/F4KMC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/879243:PORAS_RS05155 ^@ http://purl.uniprot.org/uniprot/F4KKQ3 ^@ Cofactor|||Similarity ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/879243:PORAS_RS05570 ^@ http://purl.uniprot.org/uniprot/F4KL42 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/879243:PORAS_RS01805 ^@ http://purl.uniprot.org/uniprot/F4KMS0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/879243:PORAS_RS04910 ^@ http://purl.uniprot.org/uniprot/F4KKK1 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.|||Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. http://togogenome.org/gene/879243:PORAS_RS05000 ^@ http://purl.uniprot.org/uniprot/F4KKM0 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/879243:PORAS_RS07300 ^@ http://purl.uniprot.org/uniprot/F4KN86 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS02445 ^@ http://purl.uniprot.org/uniprot/F4KNI4 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/879243:PORAS_RS02330 ^@ http://purl.uniprot.org/uniprot/F4KNG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/879243:PORAS_RS05795 ^@ http://purl.uniprot.org/uniprot/F4KLF3 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS07435 ^@ http://purl.uniprot.org/uniprot/F4KNB3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 3 Mg(2+) ions per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/879243:PORAS_RS00575 ^@ http://purl.uniprot.org/uniprot/F4KL95 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS03670 ^@ http://purl.uniprot.org/uniprot/F4KJW0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/879243:PORAS_RS07375 ^@ http://purl.uniprot.org/uniprot/F4KNA1 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/879243:PORAS_RS05530 ^@ http://purl.uniprot.org/uniprot/F4KL34 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. http://togogenome.org/gene/879243:PORAS_RS04860 ^@ http://purl.uniprot.org/uniprot/F4KKJ1 ^@ Similarity ^@ Belongs to the disproportionating enzyme family. http://togogenome.org/gene/879243:PORAS_RS00520 ^@ http://purl.uniprot.org/uniprot/F4KL85 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/879243:PORAS_RS05835 ^@ http://purl.uniprot.org/uniprot/F4KLG1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methylaspartate mutase GlmS subunit family.|||Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).|||Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer. http://togogenome.org/gene/879243:PORAS_RS06305 ^@ http://purl.uniprot.org/uniprot/F4KM34 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6. http://togogenome.org/gene/879243:PORAS_RS07430 ^@ http://purl.uniprot.org/uniprot/F4KNB2 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/879243:PORAS_RS04555 ^@ http://purl.uniprot.org/uniprot/F4KKD1 ^@ Similarity ^@ In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.|||In the central section; belongs to the CRISPR-associated helicase Cas3 family. http://togogenome.org/gene/879243:PORAS_RS08245 ^@ http://purl.uniprot.org/uniprot/F4KJG4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS00045 ^@ http://purl.uniprot.org/uniprot/F4KKT1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the precorrin methyltransferase family.|||Homodimer.|||Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. http://togogenome.org/gene/879243:PORAS_RS06710 ^@ http://purl.uniprot.org/uniprot/F4KMI4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/879243:PORAS_RS02845 ^@ http://purl.uniprot.org/uniprot/F4KNX9 ^@ Cofactor|||Similarity ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer. http://togogenome.org/gene/879243:PORAS_RS00005 ^@ http://purl.uniprot.org/uniprot/F4KKS2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DnaA family.|||Cytoplasm|||Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. http://togogenome.org/gene/879243:PORAS_RS02350 ^@ http://purl.uniprot.org/uniprot/F4KNG5 ^@ Function|||Similarity ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family.|||Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. http://togogenome.org/gene/879243:PORAS_RS02785 ^@ http://purl.uniprot.org/uniprot/F4KNW7 ^@ Similarity ^@ Belongs to the 3-oxoacid CoA-transferase subunit A family. http://togogenome.org/gene/879243:PORAS_RS00855 ^@ http://purl.uniprot.org/uniprot/F4KLL9 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurE subfamily.|||Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.|||Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS06500 ^@ http://purl.uniprot.org/uniprot/F4KM73 ^@ Subcellular Location Annotation ^@ Cell outer membrane|||Fimbrium|||Membrane http://togogenome.org/gene/879243:PORAS_RS08025 ^@ http://purl.uniprot.org/uniprot/F4KP14 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/879243:PORAS_RS02705 ^@ http://purl.uniprot.org/uniprot/F4KNU8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/879243:PORAS_RS01090 ^@ http://purl.uniprot.org/uniprot/F4KLY6 ^@ Function ^@ Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. http://togogenome.org/gene/879243:PORAS_RS06250 ^@ http://purl.uniprot.org/uniprot/F4KLV4 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/879243:PORAS_RS03070 ^@ http://purl.uniprot.org/uniprot/F4KJD1 ^@ Similarity ^@ Belongs to the bacterial reverse transcriptase family. http://togogenome.org/gene/879243:PORAS_RS01810 ^@ http://purl.uniprot.org/uniprot/F4KMS1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/879243:PORAS_RS04515 ^@ http://purl.uniprot.org/uniprot/F4KKC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/879243:PORAS_RS06385 ^@ http://purl.uniprot.org/uniprot/F4KM50 ^@ Similarity ^@ Belongs to the YicC/YloC family. http://togogenome.org/gene/879243:PORAS_RS00020 ^@ http://purl.uniprot.org/uniprot/F4KKS5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Monomer.|||The C-terminal coiled-coil domain is crucial for aminoacylation activity.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/879243:PORAS_RS00740 ^@ http://purl.uniprot.org/uniprot/F4KLJ6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AP endonuclease 2 family.|||Binds 3 Zn(2+) ions.|||Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. http://togogenome.org/gene/879243:PORAS_RS05680 ^@ http://purl.uniprot.org/uniprot/F4KLD0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/879243:PORAS_RS08260 ^@ http://purl.uniprot.org/uniprot/F4KJG7 ^@ Function|||Similarity ^@ Belongs to the aspartate/glutamate racemases family.|||Provides the (R)-glutamate required for cell wall biosynthesis. http://togogenome.org/gene/879243:PORAS_RS00610 ^@ http://purl.uniprot.org/uniprot/F4KLA2 ^@ Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. http://togogenome.org/gene/879243:PORAS_RS05825 ^@ http://purl.uniprot.org/uniprot/F4KLF9 ^@ Similarity ^@ Belongs to the Skp family. http://togogenome.org/gene/879243:PORAS_RS06670 ^@ http://purl.uniprot.org/uniprot/F4KMH5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS05005 ^@ http://purl.uniprot.org/uniprot/F4KKM1 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/879243:PORAS_RS02180 ^@ http://purl.uniprot.org/uniprot/F4KN61 ^@ Similarity ^@ Belongs to the acetyl-CoA hydrolase/transferase family. http://togogenome.org/gene/879243:PORAS_RS02365 ^@ http://purl.uniprot.org/uniprot/F4KNG8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/879243:PORAS_RS08035 ^@ http://purl.uniprot.org/uniprot/F4KP16 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/879243:PORAS_RS01835 ^@ http://purl.uniprot.org/uniprot/F4KMS7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/879243:PORAS_RS02045 ^@ http://purl.uniprot.org/uniprot/F4KN33 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/879243:PORAS_RS05615 ^@ http://purl.uniprot.org/uniprot/F4KLB5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DHBP synthase family.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Homodimer. http://togogenome.org/gene/879243:PORAS_RS04675 ^@ http://purl.uniprot.org/uniprot/F4KKF4 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/879243:PORAS_RS00885 ^@ http://purl.uniprot.org/uniprot/F4KLM5 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/879243:PORAS_RS00550 ^@ http://purl.uniprot.org/uniprot/F4KL90 ^@ Similarity ^@ Belongs to the UPF0102 family. http://togogenome.org/gene/879243:PORAS_RS02880 ^@ http://purl.uniprot.org/uniprot/F4KNY6 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/879243:PORAS_RS02085 ^@ http://purl.uniprot.org/uniprot/F4KN42 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/879243:PORAS_RS06715 ^@ http://purl.uniprot.org/uniprot/F4KMI5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell inner membrane|||Cytoplasm|||Monomer. http://togogenome.org/gene/879243:PORAS_RS07970 ^@ http://purl.uniprot.org/uniprot/F4KP03 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion per subunit.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.|||In the C-terminal section; belongs to the GTP cyclohydrolase II family.|||In the N-terminal section; belongs to the DHBP synthase family. http://togogenome.org/gene/879243:PORAS_RS00780 ^@ http://purl.uniprot.org/uniprot/F4KLK4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/879243:PORAS_RS04480 ^@ http://purl.uniprot.org/uniprot/F4KKB7 ^@ Function|||Similarity ^@ Belongs to the flavodoxin family.|||Low-potential electron donor to a number of redox enzymes. http://togogenome.org/gene/879243:PORAS_RS06400 ^@ http://purl.uniprot.org/uniprot/F4KM53 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS02310 ^@ http://purl.uniprot.org/uniprot/F4KNF6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS04560 ^@ http://purl.uniprot.org/uniprot/F4KKD2 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated protein Cas5 family. Subtype I-C/Dvulg subfamily.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/879243:PORAS_RS01275 ^@ http://purl.uniprot.org/uniprot/F4KM25 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/879243:PORAS_RS02875 ^@ http://purl.uniprot.org/uniprot/F4KNY5 ^@ Similarity ^@ Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. http://togogenome.org/gene/879243:PORAS_RS01930 ^@ http://purl.uniprot.org/uniprot/F4KMU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LpxC family.|||Belongs to the thioester dehydratase family. FabZ subfamily.|||Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.|||Cytoplasm|||Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. http://togogenome.org/gene/879243:PORAS_RS04920 ^@ http://purl.uniprot.org/uniprot/F4KKK3 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/879243:PORAS_RS03100 ^@ http://purl.uniprot.org/uniprot/F4KJD7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the urocanase family.|||Binds 1 NAD(+) per subunit.|||Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS00275 ^@ http://purl.uniprot.org/uniprot/F4KKX8 ^@ Function|||Similarity ^@ Belongs to the DHNA family.|||Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. http://togogenome.org/gene/879243:PORAS_RS05600 ^@ http://purl.uniprot.org/uniprot/F4KLB2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methylthiotransferase family. RimO subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS01130 ^@ http://purl.uniprot.org/uniprot/F4KLZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/879243:PORAS_RS00980 ^@ http://purl.uniprot.org/uniprot/F4KLW3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobD/CbiB family.|||Cell membrane|||Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/879243:PORAS_RS03345 ^@ http://purl.uniprot.org/uniprot/F4KJQ0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methylthiotransferase family. MiaB subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.|||Cytoplasm|||Monomer. http://togogenome.org/gene/879243:PORAS_RS06120 ^@ http://purl.uniprot.org/uniprot/F4KLS9 ^@ Similarity ^@ Belongs to the DprA/Smf family. http://togogenome.org/gene/879243:PORAS_RS04150 ^@ http://purl.uniprot.org/uniprot/F4KK52 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the N7 position of a guanine in 16S rRNA. http://togogenome.org/gene/879243:PORAS_RS01640 ^@ http://purl.uniprot.org/uniprot/F4KMN7 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/879243:PORAS_RS01975 ^@ http://purl.uniprot.org/uniprot/F4KN19 ^@ Similarity ^@ Belongs to the Cob(I)alamin adenosyltransferase family. http://togogenome.org/gene/879243:PORAS_RS03395 ^@ http://purl.uniprot.org/uniprot/F4KJR0 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/879243:PORAS_RS06700 ^@ http://purl.uniprot.org/uniprot/F4KMI2 ^@ Function|||PTM|||Similarity ^@ An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.|||Belongs to the polyphosphate kinase 1 (PPK1) family.|||Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). http://togogenome.org/gene/879243:PORAS_RS01330 ^@ http://purl.uniprot.org/uniprot/F4KMA5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/879243:PORAS_RS04580 ^@ http://purl.uniprot.org/uniprot/F4KKD6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/879243:PORAS_RS05770 ^@ http://purl.uniprot.org/uniprot/F4KLE8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.|||Cell inner membrane|||Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Membrane|||Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function. http://togogenome.org/gene/879243:PORAS_RS05865 ^@ http://purl.uniprot.org/uniprot/F4KLG7 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family.|||Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).|||Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS04590 ^@ http://purl.uniprot.org/uniprot/F4KKD8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS01635 ^@ http://purl.uniprot.org/uniprot/F4KMN6 ^@ Function|||Similarity ^@ Belongs to the NAD-dependent DNA ligase family. LigA subfamily.|||DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. http://togogenome.org/gene/879243:PORAS_RS05465 ^@ http://purl.uniprot.org/uniprot/F4KL20 ^@ Similarity ^@ Belongs to the CarB family. http://togogenome.org/gene/879243:PORAS_RS08350 ^@ http://purl.uniprot.org/uniprot/F4KJI6 ^@ Similarity ^@ Belongs to the PTPS family. QueD subfamily. http://togogenome.org/gene/879243:PORAS_RS05540 ^@ http://purl.uniprot.org/uniprot/F4KL36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS00645 ^@ http://purl.uniprot.org/uniprot/F4KLH6 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the peroxiredoxin family. Tpx subfamily.|||Homodimer.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/879243:PORAS_RS05915 ^@ http://purl.uniprot.org/uniprot/F4KLP0 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/879243:PORAS_RS00765 ^@ http://purl.uniprot.org/uniprot/F4KLK1 ^@ Similarity ^@ Belongs to the SufE family. http://togogenome.org/gene/879243:PORAS_RS06040 ^@ http://purl.uniprot.org/uniprot/F4KLR4 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvA family.|||Cytoplasm|||Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.|||Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA. http://togogenome.org/gene/879243:PORAS_RS08015 ^@ http://purl.uniprot.org/uniprot/F4KP12 ^@ Cofactor|||Similarity ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer. http://togogenome.org/gene/879243:PORAS_RS00860 ^@ http://purl.uniprot.org/uniprot/F4KLM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. MraY subfamily.|||Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.|||Cell inner membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS01820 ^@ http://purl.uniprot.org/uniprot/F4KMS3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/879243:PORAS_RS00280 ^@ http://purl.uniprot.org/uniprot/F4KKX9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS03965 ^@ http://purl.uniprot.org/uniprot/F4KJD1 ^@ Similarity ^@ Belongs to the bacterial reverse transcriptase family. http://togogenome.org/gene/879243:PORAS_RS07815 ^@ http://purl.uniprot.org/uniprot/F4KNQ0 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/879243:PORAS_RS04785 ^@ http://purl.uniprot.org/uniprot/F4KKH6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Maf family. YhdE subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. http://togogenome.org/gene/879243:PORAS_RS04400 ^@ http://purl.uniprot.org/uniprot/F4KKA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.|||Belongs to the RNR ribonuclease family. RNase R subfamily.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS08365 ^@ http://purl.uniprot.org/uniprot/F4KJI9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.|||Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.|||Homodimer. http://togogenome.org/gene/879243:PORAS_RS02305 ^@ http://purl.uniprot.org/uniprot/F4KNF5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS03590 ^@ http://purl.uniprot.org/uniprot/F4KJU4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/879243:PORAS_RS02865 ^@ http://purl.uniprot.org/uniprot/F4KNY3 ^@ Similarity ^@ Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/879243:PORAS_RS06680 ^@ http://purl.uniprot.org/uniprot/F4KMH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Cytoplasm|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. http://togogenome.org/gene/879243:PORAS_RS03465 ^@ http://purl.uniprot.org/uniprot/F4KJS2 ^@ Domain|||Similarity ^@ Belongs to the PurH family.|||The IMP cyclohydrolase activity resides in the N-terminal region. http://togogenome.org/gene/879243:PORAS_RS06055 ^@ http://purl.uniprot.org/uniprot/F4KLR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Membrane http://togogenome.org/gene/879243:PORAS_RS03925 ^@ http://purl.uniprot.org/uniprot/F4KK05 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/879243:PORAS_RS04375 ^@ http://purl.uniprot.org/uniprot/F4KK95 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the Rho family.|||Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.|||Homohexamer. The homohexamer assembles into an open ring structure.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS07195 ^@ http://purl.uniprot.org/uniprot/F4KN00 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/879243:PORAS_RS03130 ^@ http://purl.uniprot.org/uniprot/F4KJE3 ^@ Similarity ^@ Belongs to the acetyl-CoA hydrolase/transferase family. http://togogenome.org/gene/879243:PORAS_RS06510 ^@ http://purl.uniprot.org/uniprot/F4KM75 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/879243:PORAS_RS01765 ^@ http://purl.uniprot.org/uniprot/F4KMR2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/879243:PORAS_RS07500 ^@ http://purl.uniprot.org/uniprot/F4KNC6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/879243:PORAS_RS05485 ^@ http://purl.uniprot.org/uniprot/F4KL24 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/879243:PORAS_RS03570 ^@ http://purl.uniprot.org/uniprot/F4KJU0 ^@ Similarity ^@ Belongs to the AIR synthase family. http://togogenome.org/gene/879243:PORAS_RS05185 ^@ http://purl.uniprot.org/uniprot/F4KKQ9 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/879243:PORAS_RS04135 ^@ http://purl.uniprot.org/uniprot/F4KK49 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MscL family.|||Cell inner membrane|||Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.|||Homopentamer.|||Membrane http://togogenome.org/gene/879243:PORAS_RS00290 ^@ http://purl.uniprot.org/uniprot/F4KKY1 ^@ Function|||Similarity ^@ Belongs to the glucose-1-phosphate thymidylyltransferase family.|||Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. http://togogenome.org/gene/879243:PORAS_RS00815 ^@ http://purl.uniprot.org/uniprot/F4KLL1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrB/RnfD family.|||Cell inner membrane|||Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.|||NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. http://togogenome.org/gene/879243:PORAS_RS06635 ^@ http://purl.uniprot.org/uniprot/F4KMG8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS07070 ^@ http://purl.uniprot.org/uniprot/F4KMX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial sugar transferase family.|||Membrane http://togogenome.org/gene/879243:PORAS_RS01815 ^@ http://purl.uniprot.org/uniprot/F4KMS2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/879243:PORAS_RS06380 ^@ http://purl.uniprot.org/uniprot/F4KM49 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell inner membrane|||Cytoplasm|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/879243:PORAS_RS03980 ^@ http://purl.uniprot.org/uniprot/F4KK18 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/879243:PORAS_RS02640 ^@ http://purl.uniprot.org/uniprot/F4KNT6 ^@ Function|||Similarity ^@ Belongs to the RecN family.|||May be involved in recombinational repair of damaged DNA. http://togogenome.org/gene/879243:PORAS_RS00400 ^@ http://purl.uniprot.org/uniprot/F4KL62 ^@ Similarity ^@ Belongs to the peptidase S51 family. http://togogenome.org/gene/879243:PORAS_RS05930 ^@ http://purl.uniprot.org/uniprot/F4KLP3 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/879243:PORAS_RS04835 ^@ http://purl.uniprot.org/uniprot/F4KKI6 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/879243:PORAS_RS04875 ^@ http://purl.uniprot.org/uniprot/F4KKJ4 ^@ Function|||Similarity ^@ ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. http://togogenome.org/gene/879243:PORAS_RS02575 ^@ http://purl.uniprot.org/uniprot/F4KNL0 ^@ Similarity ^@ Belongs to the bacteroidetes fimbrillin superfamily. FimB/Mfa2 family. http://togogenome.org/gene/879243:PORAS_RS03350 ^@ http://purl.uniprot.org/uniprot/F4KJQ1 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/879243:PORAS_RS02610 ^@ http://purl.uniprot.org/uniprot/F4KNT0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.|||Belongs to the peptidase C25 family. http://togogenome.org/gene/879243:PORAS_RS08535 ^@ http://purl.uniprot.org/uniprot/F4KJM3 ^@ Similarity ^@ Belongs to the phosphate acetyltransferase and butyryltransferase family. http://togogenome.org/gene/879243:PORAS_RS02345 ^@ http://purl.uniprot.org/uniprot/F4KNG4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS07530 ^@ http://purl.uniprot.org/uniprot/F4KND2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/879243:PORAS_RS05410 ^@ http://purl.uniprot.org/uniprot/F4KL12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/879243:PORAS_RS07955 ^@ http://purl.uniprot.org/uniprot/F4KP00 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endoribonuclease YbeY family.|||Binds 1 zinc ion.|||Cytoplasm|||Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. http://togogenome.org/gene/879243:PORAS_RS01320 ^@ http://purl.uniprot.org/uniprot/F4KMA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/879243:PORAS_RS02805 ^@ http://purl.uniprot.org/uniprot/F4KNX1 ^@ Similarity ^@ Belongs to the radical SAM superfamily. KamA family. http://togogenome.org/gene/879243:PORAS_RS01470 ^@ http://purl.uniprot.org/uniprot/F4KMD3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/879243:PORAS_RS01780 ^@ http://purl.uniprot.org/uniprot/F4KMR5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/879243:PORAS_RS00870 ^@ http://purl.uniprot.org/uniprot/F4KLM2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS06655 ^@ http://purl.uniprot.org/uniprot/F4KMH2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/879243:PORAS_RS03440 ^@ http://purl.uniprot.org/uniprot/F4KJR7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/879243:PORAS_RS00375 ^@ http://purl.uniprot.org/uniprot/F4KL57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ArgR family.|||Cytoplasm|||Regulates arginine biosynthesis genes. http://togogenome.org/gene/879243:PORAS_RS07455 ^@ http://purl.uniprot.org/uniprot/F4KNB7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrI family.|||Binds 1 zinc ion per subunit.|||Contains catalytic and regulatory chains.|||Involved in allosteric regulation of aspartate carbamoyltransferase. http://togogenome.org/gene/879243:PORAS_RS05275 ^@ http://purl.uniprot.org/uniprot/F4KKZ0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/879243:PORAS_RS05565 ^@ http://purl.uniprot.org/uniprot/F4KL41 ^@ Function|||Similarity ^@ Belongs to the LpxK family.|||Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). http://togogenome.org/gene/879243:PORAS_RS03830 ^@ http://purl.uniprot.org/uniprot/F4KJY8 ^@ Function|||Similarity ^@ Belongs to the dihydrofolate reductase family.|||Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. http://togogenome.org/gene/879243:PORAS_RS02545 ^@ http://purl.uniprot.org/uniprot/F4KNK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAE transporter (TC 2.A.81) family.|||Cell membrane|||Membrane