http://togogenome.org/gene/8839:PIGW ^@ http://purl.uniprot.org/uniprot/R0LTQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGW family.|||Endoplasmic reticulum membrane|||Membrane|||Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. http://togogenome.org/gene/8839:NPY4R2 ^@ http://purl.uniprot.org/uniprot/R0JPY5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8839:SLC7A6 ^@ http://purl.uniprot.org/uniprot/R0JI70 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:TSHR ^@ http://purl.uniprot.org/uniprot/R0LII3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||Lateral cell membrane|||Membrane|||Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. http://togogenome.org/gene/8839:ASIP ^@ http://purl.uniprot.org/uniprot/S4S2Z6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/8839:GLDC ^@ http://purl.uniprot.org/uniprot/Q9PUU9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvP family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/8839:LOC101795347 ^@ http://purl.uniprot.org/uniprot/A0A8B9TDA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/8839:ALG2 ^@ http://purl.uniprot.org/uniprot/R0JF31 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.|||Membrane http://togogenome.org/gene/8839:EIF4A2 ^@ http://purl.uniprot.org/uniprot/A0A8B9TQG1 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/8839:CTTNBP2 ^@ http://purl.uniprot.org/uniprot/A0A8B9TLS3 ^@ Subcellular Location Annotation ^@ cell cortex|||dendritic spine http://togogenome.org/gene/8839:ROPN1L ^@ http://purl.uniprot.org/uniprot/A0A8B9QR07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ropporin family.|||flagellum http://togogenome.org/gene/8839:TMEM182 ^@ http://purl.uniprot.org/uniprot/A0A8B9SF66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM182 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:ST3GAL6 ^@ http://purl.uniprot.org/uniprot/R0M6H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8839:A4GNT ^@ http://purl.uniprot.org/uniprot/A0A8B9QRS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 32 family.|||Golgi apparatus membrane http://togogenome.org/gene/8839:ALDH8A1 ^@ http://purl.uniprot.org/uniprot/R0LUD3 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/8839:HAO1 ^@ http://purl.uniprot.org/uniprot/A0A8B9T251 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/8839:CDX4 ^@ http://purl.uniprot.org/uniprot/A0A8B9QXL8|||http://purl.uniprot.org/uniprot/R0KF85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/8839:MC4R ^@ http://purl.uniprot.org/uniprot/R0K294 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). http://togogenome.org/gene/8839:MMP7 ^@ http://purl.uniprot.org/uniprot/A0A8B9QZI0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/8839:LOC101795634 ^@ http://purl.uniprot.org/uniprot/A0A8B9SGH2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8839:LOC101805135 ^@ http://purl.uniprot.org/uniprot/A0A8B9SGR1|||http://purl.uniprot.org/uniprot/A0A8B9SHT1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:CHST8 ^@ http://purl.uniprot.org/uniprot/A0A8B9SW31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8839:BLK ^@ http://purl.uniprot.org/uniprot/A0A8B9QV67 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/8839:GSTT2B ^@ http://purl.uniprot.org/uniprot/A0A8B9SM10 ^@ Similarity ^@ Belongs to the GST superfamily. Theta family. http://togogenome.org/gene/8839:MYD88 ^@ http://purl.uniprot.org/uniprot/A0A0G2YMQ3 ^@ Function|||Subcellular Location Annotation ^@ Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.|||Cytoplasm http://togogenome.org/gene/8839:MSRB3 ^@ http://purl.uniprot.org/uniprot/R0L7M1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit.|||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. http://togogenome.org/gene/8839:IDH1 ^@ http://purl.uniprot.org/uniprot/A0A8B9SQI5 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/8839:LOC101803775 ^@ http://purl.uniprot.org/uniprot/A0A8B9SQS1 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8839:CTNNB1 ^@ http://purl.uniprot.org/uniprot/B5U453 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/8839:SGMS2 ^@ http://purl.uniprot.org/uniprot/R0LL24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/8839:LDB2 ^@ http://purl.uniprot.org/uniprot/R0K0T1 ^@ Similarity ^@ Belongs to the LDB family. http://togogenome.org/gene/8839:KEG62_p11 ^@ http://purl.uniprot.org/uniprot/A6ZJ01 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8839:SMC6 ^@ http://purl.uniprot.org/uniprot/A0A8B9QX51 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/8839:GTF2H1 ^@ http://purl.uniprot.org/uniprot/R0L479 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB1 family.|||Nucleus http://togogenome.org/gene/8839:PRIMPOL ^@ http://purl.uniprot.org/uniprot/R0J9J2 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/8839:PPM1K ^@ http://purl.uniprot.org/uniprot/R0KJ09 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/8839:LOC101800713 ^@ http://purl.uniprot.org/uniprot/R0JDK1 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/8839:HNF1A ^@ http://purl.uniprot.org/uniprot/R0L7K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HNF1 homeobox family.|||Nucleus http://togogenome.org/gene/8839:TMEM144 ^@ http://purl.uniprot.org/uniprot/R0K0M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM144 family.|||Membrane http://togogenome.org/gene/8839:AGPAT3 ^@ http://purl.uniprot.org/uniprot/R0K9G9 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/8839:RNH1 ^@ http://purl.uniprot.org/uniprot/R0LWZ6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.|||Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. http://togogenome.org/gene/8839:LOC101789606 ^@ http://purl.uniprot.org/uniprot/Q27YS3 ^@ Caution|||Function|||Subunit ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.|||Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. http://togogenome.org/gene/8839:FAM174B ^@ http://purl.uniprot.org/uniprot/R0KAY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/8839:C1D ^@ http://purl.uniprot.org/uniprot/A0A8B9T8N6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the C1D family.|||Cytoplasm|||Monomer and homodimer.|||Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.|||nucleolus http://togogenome.org/gene/8839:RPL15 ^@ http://purl.uniprot.org/uniprot/A0A8B9TMD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL15 family.|||Cytoplasm http://togogenome.org/gene/8839:HSPB2 ^@ http://purl.uniprot.org/uniprot/A0A8B9QZH2 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/8839:TLR2 ^@ http://purl.uniprot.org/uniprot/M9NII1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.|||Membrane http://togogenome.org/gene/8839:LSM3 ^@ http://purl.uniprot.org/uniprot/A0A8B9T9S9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/8839:AZIN1 ^@ http://purl.uniprot.org/uniprot/R0KD83 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/8839:PAX3 ^@ http://purl.uniprot.org/uniprot/I7EXJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/8839:SMIM18 ^@ http://purl.uniprot.org/uniprot/R0KVR2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:FRMPD2 ^@ http://purl.uniprot.org/uniprot/A0A8B9TDT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/8839:LOC101797338 ^@ http://purl.uniprot.org/uniprot/R0LXX7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/8839:KCNJ8 ^@ http://purl.uniprot.org/uniprot/R0LBG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/8839:ATP11A ^@ http://purl.uniprot.org/uniprot/A0A8B9R6J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/8839:ATP2A2 ^@ http://purl.uniprot.org/uniprot/R0LTI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Endoplasmic reticulum membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/8839:RNASET2 ^@ http://purl.uniprot.org/uniprot/R0JWF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase T2 family.|||Lysosome lumen http://togogenome.org/gene/8839:CWC15 ^@ http://purl.uniprot.org/uniprot/R0M0S7 ^@ Similarity ^@ Belongs to the CWC15 family. http://togogenome.org/gene/8839:FUT7 ^@ http://purl.uniprot.org/uniprot/R0K5B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/8839:STMN2 ^@ http://purl.uniprot.org/uniprot/A0A8B9SPQ2 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/8839:LOC101803429 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZAQ4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/8839:DDX58 ^@ http://purl.uniprot.org/uniprot/D3TI84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/8839:TRAF6 ^@ http://purl.uniprot.org/uniprot/X5FNT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family. A subfamily.|||Lipid droplet|||Nucleus|||cell cortex http://togogenome.org/gene/8839:PIWIL1 ^@ http://purl.uniprot.org/uniprot/A0A8B9T7Q0 ^@ Similarity ^@ Belongs to the argonaute family. http://togogenome.org/gene/8839:LOC101802620 ^@ http://purl.uniprot.org/uniprot/A0A8B9TJS8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:CRHR2 ^@ http://purl.uniprot.org/uniprot/R0M1I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Membrane http://togogenome.org/gene/8839:MCM8 ^@ http://purl.uniprot.org/uniprot/R0L7Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/8839:TPM1 ^@ http://purl.uniprot.org/uniprot/A0A8B9TEN7|||http://purl.uniprot.org/uniprot/A0A8B9TER4|||http://purl.uniprot.org/uniprot/A0A8B9ZI02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/8839:GNB1 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZJ82 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/8839:LOC101803608 ^@ http://purl.uniprot.org/uniprot/R0LP91 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:LOC101800783 ^@ http://purl.uniprot.org/uniprot/V5J2K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MUSTANG family.|||Nucleus http://togogenome.org/gene/8839:P2RY13 ^@ http://purl.uniprot.org/uniprot/A0A8B9THN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:PIK3CA ^@ http://purl.uniprot.org/uniprot/A0A8B9TNQ1 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/8839:BTG4 ^@ http://purl.uniprot.org/uniprot/R0LF13 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/8839:LOC101792626 ^@ http://purl.uniprot.org/uniprot/Q2HZF4 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8839:MB ^@ http://purl.uniprot.org/uniprot/R0K422 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. http://togogenome.org/gene/8839:OLAH ^@ http://purl.uniprot.org/uniprot/A0A8B9TK78|||http://purl.uniprot.org/uniprot/P00633 ^@ Function|||Similarity ^@ Belongs to the thioesterase family.|||In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length fatty acids (C8 to C2). http://togogenome.org/gene/8839:IL2RG ^@ http://purl.uniprot.org/uniprot/F2W9Z7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:TNFAIP1 ^@ http://purl.uniprot.org/uniprot/R0L3R1 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/8839:TSSC4 ^@ http://purl.uniprot.org/uniprot/R0L6J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TSSC4 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8839:GNGT2 ^@ http://purl.uniprot.org/uniprot/R0JH78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/8839:PRLR ^@ http://purl.uniprot.org/uniprot/A5HDY5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Membrane|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation.|||This is a receptor for the anterior pituitary hormone prolactin. http://togogenome.org/gene/8839:GJB1 ^@ http://purl.uniprot.org/uniprot/R0K0K1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8839:LOC101802909 ^@ http://purl.uniprot.org/uniprot/Q4VSK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/8839:EHD3 ^@ http://purl.uniprot.org/uniprot/R0LDH3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/8839:BOK ^@ http://purl.uniprot.org/uniprot/R0KNK1 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/8839:EGF ^@ http://purl.uniprot.org/uniprot/R0JVC3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8839:NKAIN4 ^@ http://purl.uniprot.org/uniprot/A0A8B9SVG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:FLI1 ^@ http://purl.uniprot.org/uniprot/A0A8B9TAP7|||http://purl.uniprot.org/uniprot/A0A8B9TBN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/8839:MAB21L1 ^@ http://purl.uniprot.org/uniprot/R0LNV1 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/8839:PRL ^@ http://purl.uniprot.org/uniprot/Q75RW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/8839:CYLD ^@ http://purl.uniprot.org/uniprot/R0LE64 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||centrosome|||cilium basal body|||perinuclear region|||spindle http://togogenome.org/gene/8839:POLR2K ^@ http://purl.uniprot.org/uniprot/A0A8B9QXW2 ^@ Similarity ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family. http://togogenome.org/gene/8839:SLC1A1 ^@ http://purl.uniprot.org/uniprot/A0A088MHD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/8839:TF ^@ http://purl.uniprot.org/uniprot/A0A8B9TQT4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transferrin family.|||Monomer.|||Secreted http://togogenome.org/gene/8839:LOC101802625 ^@ http://purl.uniprot.org/uniprot/A0A8B9SRR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tdpoz family.|||Nucleus speckle http://togogenome.org/gene/8839:PFDN4 ^@ http://purl.uniprot.org/uniprot/A0A8B9TNT5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/8839:MPPED2 ^@ http://purl.uniprot.org/uniprot/R0L1Q0 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/8839:MGST2 ^@ http://purl.uniprot.org/uniprot/A0A8B9QUL6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8839:OAZ1 ^@ http://purl.uniprot.org/uniprot/A0A8B9TH31 ^@ Similarity ^@ Belongs to the ODC antizyme family. http://togogenome.org/gene/8839:LIPI ^@ http://purl.uniprot.org/uniprot/A0A8B9QPL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/8839:HOXB9 ^@ http://purl.uniprot.org/uniprot/A0A8B9QYJ6|||http://purl.uniprot.org/uniprot/R0L8K2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/8839:FAM83H ^@ http://purl.uniprot.org/uniprot/R0JHG4 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/8839:VPS26B ^@ http://purl.uniprot.org/uniprot/A0A8B9T247 ^@ Similarity ^@ Belongs to the VPS26 family. http://togogenome.org/gene/8839:MYF6 ^@ http://purl.uniprot.org/uniprot/D5FZH6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8839:NTMT1 ^@ http://purl.uniprot.org/uniprot/A0A8B9STA9 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/8839:ARPC1A ^@ http://purl.uniprot.org/uniprot/A0A8B9TDG1 ^@ Function|||Similarity ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. http://togogenome.org/gene/8839:LZIC ^@ http://purl.uniprot.org/uniprot/A0A8B9TWP3 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/8839:ADI1 ^@ http://purl.uniprot.org/uniprot/A0A8B9Z7D8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acireductone dioxygenase (ARD) family.|||Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.|||Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.|||Cell membrane|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/8839:SLC7A4 ^@ http://purl.uniprot.org/uniprot/A0A088MKA6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:NPTX2 ^@ http://purl.uniprot.org/uniprot/R0LKI1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8839:LOC101791461 ^@ http://purl.uniprot.org/uniprot/R0JUP5 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/8839:LOC101797718 ^@ http://purl.uniprot.org/uniprot/Q5QFI1 ^@ Function|||Similarity ^@ Belongs to the apovitellenin family.|||Protein component of the very low density lipoprotein (VLDL) of egg-laying females. Potent lipoprotein lipase inhibitor, preventing the loss of triglycerides from VLDL on their way from the liver to the growing oocytes. http://togogenome.org/gene/8839:VGLL4 ^@ http://purl.uniprot.org/uniprot/R0K604 ^@ Function|||Similarity ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs. http://togogenome.org/gene/8839:GFRA4 ^@ http://purl.uniprot.org/uniprot/A0A8B9T090 ^@ Similarity ^@ Belongs to the GDNFR family. http://togogenome.org/gene/8839:SSTR3 ^@ http://purl.uniprot.org/uniprot/R0LU63 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8839:SPI1 ^@ http://purl.uniprot.org/uniprot/A0A8B9SQM9|||http://purl.uniprot.org/uniprot/A0A8B9SQR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/8839:MMP23B ^@ http://purl.uniprot.org/uniprot/R0LPB3 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8839:LOC101799765 ^@ http://purl.uniprot.org/uniprot/L7R9Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/8839:IGF1 ^@ http://purl.uniprot.org/uniprot/A2IT63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/8839:AMOT ^@ http://purl.uniprot.org/uniprot/A0A8B9T9B2 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/8839:UTS2 ^@ http://purl.uniprot.org/uniprot/A0A8B9T0V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urotensin-2 family.|||Secreted http://togogenome.org/gene/8839:B3GNT9 ^@ http://purl.uniprot.org/uniprot/A0A8B9TQF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8839:CLDN16 ^@ http://purl.uniprot.org/uniprot/A0A8B9T7V3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/8839:LOC101794808 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZHJ8 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/8839:CCND1 ^@ http://purl.uniprot.org/uniprot/R0JP78 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/8839:IL2RB ^@ http://purl.uniprot.org/uniprot/A0A8B9SUF6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Cell membrane|||Membrane|||Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. http://togogenome.org/gene/8839:CYFIP1 ^@ http://purl.uniprot.org/uniprot/A0A8B9QUM5 ^@ Similarity ^@ Belongs to the CYFIP family. http://togogenome.org/gene/8839:FGG ^@ http://purl.uniprot.org/uniprot/A0A8B9SHX5 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/8839:LOC101789562 ^@ http://purl.uniprot.org/uniprot/A0A8B9SWM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/8839:LOC101794184 ^@ http://purl.uniprot.org/uniprot/A0A8B9R3M6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/8839:LOC101793492 ^@ http://purl.uniprot.org/uniprot/A0A8B9QTQ5|||http://purl.uniprot.org/uniprot/P33238 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.|||By interferons.|||Cytoplasm|||Does not show activity against influenza virus or VSV.|||Nucleus http://togogenome.org/gene/8839:DUSP26 ^@ http://purl.uniprot.org/uniprot/A0A8B9SVG7 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/8839:LOC101789807 ^@ http://purl.uniprot.org/uniprot/A0A8B9SPQ4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8839:COMT ^@ http://purl.uniprot.org/uniprot/R0JKM2 ^@ Cofactor|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/8839:LOC101792815 ^@ http://purl.uniprot.org/uniprot/A0A8B9SPZ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||May play a role in lipid transport protein in Schwann cells. May bind cholesterol.|||Monomer. http://togogenome.org/gene/8839:SLC41A3 ^@ http://purl.uniprot.org/uniprot/R0JJE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/8839:VAMP7 ^@ http://purl.uniprot.org/uniprot/A0A8B9SI66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/8839:PLOD1 ^@ http://purl.uniprot.org/uniprot/A0A8B9T868 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/8839:LOC101800628 ^@ http://purl.uniprot.org/uniprot/R0JY18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYBC1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8839:ZC3H12B ^@ http://purl.uniprot.org/uniprot/R0LIW5 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/8839:SEC23B ^@ http://purl.uniprot.org/uniprot/R0KAE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/8839:FAM20B ^@ http://purl.uniprot.org/uniprot/R0L7G4 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/8839:CRYAB ^@ http://purl.uniprot.org/uniprot/Q05557 ^@ Function|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the small heat shock protein (HSP20) family.|||Heteromer composed of three CRYAA and one CRYAB subunits. Aggregates with homologous proteins, including the small heat shock protein HSPB1, to form large heteromeric complexes. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens (By similarity).|||Lens as well as other tissues.|||May contribute to the transparency and refractive index of the lens. http://togogenome.org/gene/8839:EML4 ^@ http://purl.uniprot.org/uniprot/A0A8B9SIS3 ^@ Similarity ^@ Belongs to the WD repeat EMAP family. http://togogenome.org/gene/8839:TMEM45B ^@ http://purl.uniprot.org/uniprot/R0JVR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/8839:SCPEP1 ^@ http://purl.uniprot.org/uniprot/A0A8B9SRQ2 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/8839:SGMS1 ^@ http://purl.uniprot.org/uniprot/A0A8B9T045 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/8839:CX3CR1 ^@ http://purl.uniprot.org/uniprot/A0A8B9TLI6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8839:FOXJ2 ^@ http://purl.uniprot.org/uniprot/A0A8B9TEJ3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8839:SNX5 ^@ http://purl.uniprot.org/uniprot/A0A8B9R1J2 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/8839:POLR3F ^@ http://purl.uniprot.org/uniprot/R0M2C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/8839:FGD3 ^@ http://purl.uniprot.org/uniprot/A0A8B9TVD5 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/8839:EXOG ^@ http://purl.uniprot.org/uniprot/A0A8B9QN82 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/8839:LOC101799083 ^@ http://purl.uniprot.org/uniprot/A0A8B9SFM4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8839:LOC101791068 ^@ http://purl.uniprot.org/uniprot/A0A8B9SGL2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8839:MAPK13 ^@ http://purl.uniprot.org/uniprot/R0JM53 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Interacts with MAPK8IP2. http://togogenome.org/gene/8839:LOC101794704 ^@ http://purl.uniprot.org/uniprot/A0A8B9SW49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/8839:GPATCH11 ^@ http://purl.uniprot.org/uniprot/A0A8B9SZQ9 ^@ Similarity ^@ Belongs to the GPATCH11 family. http://togogenome.org/gene/8839:GJC1 ^@ http://purl.uniprot.org/uniprot/R0L8V9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Gamma-type subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8839:IL-2 ^@ http://purl.uniprot.org/uniprot/Q8JFF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/8839:EPS8 ^@ http://purl.uniprot.org/uniprot/A0A8B9TGA0 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/8839:C1GALT1 ^@ http://purl.uniprot.org/uniprot/R0KB96 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:MED7 ^@ http://purl.uniprot.org/uniprot/R0KLM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 7 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/8839:RAB27B ^@ http://purl.uniprot.org/uniprot/R0KAX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/8839:PARVB ^@ http://purl.uniprot.org/uniprot/A0A8B9SMT9 ^@ Similarity ^@ Belongs to the parvin family. http://togogenome.org/gene/8839:CER1 ^@ http://purl.uniprot.org/uniprot/R0L8F5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8839:LOC101794469 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZK04 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8839:SLC1A7 ^@ http://purl.uniprot.org/uniprot/R0JFA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/8839:NDUFA8 ^@ http://purl.uniprot.org/uniprot/R0JBK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I NDUFA8 subunit family.|||Mitochondrion intermembrane space http://togogenome.org/gene/8839:KEG62_p04 ^@ http://purl.uniprot.org/uniprot/A6ZJ08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/8839:SULF1 ^@ http://purl.uniprot.org/uniprot/A0A8B9THE6 ^@ Cofactor|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Binds 1 Ca(2+) ion per subunit.|||Cell surface|||Endoplasmic reticulum|||Golgi stack|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/8839:ATP1B1 ^@ http://purl.uniprot.org/uniprot/Q6TG02 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/8839:PDE7B ^@ http://purl.uniprot.org/uniprot/A0A8B9TB56 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/8839:RIOX1 ^@ http://purl.uniprot.org/uniprot/R0JQV0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ROX family.|||Binds 1 Fe(2+) ion per subunit.|||Nucleus|||Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. http://togogenome.org/gene/8839:MAFB ^@ http://purl.uniprot.org/uniprot/R0KAI9 ^@ Similarity ^@ Belongs to the bZIP family. Maf subfamily. http://togogenome.org/gene/8839:RIC8A ^@ http://purl.uniprot.org/uniprot/R0JAB5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. http://togogenome.org/gene/8839:WNT8A ^@ http://purl.uniprot.org/uniprot/R0JCI1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/8839:LOC101790057 ^@ http://purl.uniprot.org/uniprot/R0KF96 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8839:LOC101794661 ^@ http://purl.uniprot.org/uniprot/A0A8B9R519 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8839:TFAP2D ^@ http://purl.uniprot.org/uniprot/A0A8B9SH76 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/8839:ZNF532 ^@ http://purl.uniprot.org/uniprot/R0LDY0 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/8839:DGLUCY ^@ http://purl.uniprot.org/uniprot/A0A8B9SR88 ^@ Similarity ^@ Belongs to the D-glutamate cyclase family. http://togogenome.org/gene/8839:BDKRB2 ^@ http://purl.uniprot.org/uniprot/R0LJA7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.|||Membrane|||Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/8839:RFC1 ^@ http://purl.uniprot.org/uniprot/Q90238 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the activator 1 large subunit family.|||Nucleus http://togogenome.org/gene/8839:TICAM1 ^@ http://purl.uniprot.org/uniprot/A0A023PSZ2 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Homodimer. Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1.|||Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.|||Mitochondrion|||The N-terminal region is essential for activation of the IFNB promoter activity.|||autophagosome|||cytosol http://togogenome.org/gene/8839:GRIA4 ^@ http://purl.uniprot.org/uniprot/A0A8B9QT37|||http://purl.uniprot.org/uniprot/R0K213 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/8839:NIPAL2 ^@ http://purl.uniprot.org/uniprot/A0A8B9QZJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/8839:SCN3B ^@ http://purl.uniprot.org/uniprot/A0A8B9TQU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.|||Membrane|||Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. http://togogenome.org/gene/8839:RNF146 ^@ http://purl.uniprot.org/uniprot/R0M7I3 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.|||The WWE domain mediates non-covalent poly(ADP-ribose)-binding.|||Ubiquitinated; autoubiquitinated.|||cytosol http://togogenome.org/gene/8839:MFN1 ^@ http://purl.uniprot.org/uniprot/A0A8B9TRP9 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/8839:PHB ^@ http://purl.uniprot.org/uniprot/A0A8B9QZA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Cell membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8839:RAB27A ^@ http://purl.uniprot.org/uniprot/R0M2P9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/8839:LOC101803101 ^@ http://purl.uniprot.org/uniprot/R0LYJ5 ^@ Similarity ^@ In the C-terminal section; belongs to the GART family.|||In the N-terminal section; belongs to the GARS family.|||In the central section; belongs to the AIR synthase family. http://togogenome.org/gene/8839:CD9 ^@ http://purl.uniprot.org/uniprot/A0A8B9SFD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Cell membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/8839:CTLA4 ^@ http://purl.uniprot.org/uniprot/D0V088 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.|||Membrane http://togogenome.org/gene/8839:ATP5F1E ^@ http://purl.uniprot.org/uniprot/R0LQK3 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ATPase epsilon family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/8839:ADIPOR2 ^@ http://purl.uniprot.org/uniprot/Q2I0Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/8839:RSPO3 ^@ http://purl.uniprot.org/uniprot/A0A8B9Z827 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/8839:LOC101801660 ^@ http://purl.uniprot.org/uniprot/A0A8B9T190 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:SLC24A1 ^@ http://purl.uniprot.org/uniprot/R0LV70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/8839:GDF2 ^@ http://purl.uniprot.org/uniprot/R0LGL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/8839:LOC101800520 ^@ http://purl.uniprot.org/uniprot/P04442 ^@ Developmental Stage|||Function|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the globin family.|||Heterotetramer of two alpha-D chains and two beta chains.|||In birds, the alpha-D chain occurs in a minor hemoglobin component, called hemoglobin d, which is expressed in late embryonic and adult life.|||Involved in oxygen transport from the lung to the various peripheral tissues.|||Red blood cells. http://togogenome.org/gene/8839:LOC101790335 ^@ http://purl.uniprot.org/uniprot/R0LMR1 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/8839:EDNRA ^@ http://purl.uniprot.org/uniprot/R0LH46 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/8839:GPNMB ^@ http://purl.uniprot.org/uniprot/A0A8B9QSZ3 ^@ Similarity ^@ Belongs to the PMEL/NMB family. http://togogenome.org/gene/8839:UGP2 ^@ http://purl.uniprot.org/uniprot/A0A8B9T7Q7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Homooctamer.|||UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. http://togogenome.org/gene/8839:LOC101799731 ^@ http://purl.uniprot.org/uniprot/A0A8B9T1H7 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/8839:ANAPC10 ^@ http://purl.uniprot.org/uniprot/R0K4H8 ^@ Similarity ^@ Belongs to the APC10 family. http://togogenome.org/gene/8839:LOC101805222 ^@ http://purl.uniprot.org/uniprot/A0A8B9QZH1 ^@ Similarity ^@ Belongs to the osteocalcin/matrix Gla protein family. http://togogenome.org/gene/8839:MEF2C ^@ http://purl.uniprot.org/uniprot/I6VVT0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8839:RAB32 ^@ http://purl.uniprot.org/uniprot/A0A8B9TBF7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/8839:GPR155 ^@ http://purl.uniprot.org/uniprot/A0A8B9SKP0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:CD40LG ^@ http://purl.uniprot.org/uniprot/B5LX77|||http://purl.uniprot.org/uniprot/B5LX80 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.|||Belongs to the tumor necrosis factor family.|||Cell surface|||Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.|||Homotrimer. http://togogenome.org/gene/8839:ANXA13 ^@ http://purl.uniprot.org/uniprot/A0A8B9TDN2|||http://purl.uniprot.org/uniprot/A0A8B9TE93 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/8839:LRRC8B ^@ http://purl.uniprot.org/uniprot/R0L2M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:GPR55 ^@ http://purl.uniprot.org/uniprot/A0A8B9TDE9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8839:KCNG1 ^@ http://purl.uniprot.org/uniprot/A0A8B9TMF8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:TACR3 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZL63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:TTI2 ^@ http://purl.uniprot.org/uniprot/R0KWG9 ^@ Similarity ^@ Belongs to the TTI2 family. http://togogenome.org/gene/8839:KCND3 ^@ http://purl.uniprot.org/uniprot/R0K771 ^@ Subcellular Location Annotation ^@ Membrane|||dendrite http://togogenome.org/gene/8839:SFR1 ^@ http://purl.uniprot.org/uniprot/R0M8M8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SFR1/MEI5 family.|||Nucleus http://togogenome.org/gene/8839:RPL7 ^@ http://purl.uniprot.org/uniprot/A0A8B9SQN3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/8839:NSMCE1 ^@ http://purl.uniprot.org/uniprot/A0A8B9QVV3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE1 family.|||Component of the Smc5-Smc6 complex.|||Nucleus|||RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.|||telomere http://togogenome.org/gene/8839:ELAVL4 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZKL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm|||Perikaryon|||axon|||dendrite|||growth cone http://togogenome.org/gene/8839:LOC101797806 ^@ http://purl.uniprot.org/uniprot/R0L488 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/8839:RTN1 ^@ http://purl.uniprot.org/uniprot/A0A8B9SNC6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8839:DLX1 ^@ http://purl.uniprot.org/uniprot/A0A8B9SUL8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8839:MC2R ^@ http://purl.uniprot.org/uniprot/R0LPF7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).|||Membrane http://togogenome.org/gene/8839:MAPKAPK3 ^@ http://purl.uniprot.org/uniprot/R0JHI4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8839:SOAT1 ^@ http://purl.uniprot.org/uniprot/A0A8B9TQK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8839:LOC101793645 ^@ http://purl.uniprot.org/uniprot/R0LUA1 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/8839:RAB9B ^@ http://purl.uniprot.org/uniprot/R0L267 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||phagosome membrane http://togogenome.org/gene/8839:EREG ^@ http://purl.uniprot.org/uniprot/A0A8B9T3C9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8839:TIMP3 ^@ http://purl.uniprot.org/uniprot/R0KBG0 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/8839:CALHM2 ^@ http://purl.uniprot.org/uniprot/R0L4V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/8839:MPPED1 ^@ http://purl.uniprot.org/uniprot/R0JBB5 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/8839:ASPN ^@ http://purl.uniprot.org/uniprot/A0A8B9TVJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||extracellular matrix http://togogenome.org/gene/8839:LANCL1 ^@ http://purl.uniprot.org/uniprot/R0JR71 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/8839:LOC101804810 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZH41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8839:DLC1 ^@ http://purl.uniprot.org/uniprot/A0A8B9T536 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8839:GLP1R ^@ http://purl.uniprot.org/uniprot/A0A8B9SQS9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8839:EHF ^@ http://purl.uniprot.org/uniprot/R0LNP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/8839:BFSP1 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZFN2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||cell cortex|||cytoskeleton http://togogenome.org/gene/8839:GPR34 ^@ http://purl.uniprot.org/uniprot/A0A8B9T978 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Orphan receptor. http://togogenome.org/gene/8839:LOC101792365 ^@ http://purl.uniprot.org/uniprot/A0A8B9SRL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/8839:MALL ^@ http://purl.uniprot.org/uniprot/A0A8B9ZGS2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:FUT8 ^@ http://purl.uniprot.org/uniprot/A0A8B9SQH4|||http://purl.uniprot.org/uniprot/R0L7J0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 23 family.|||Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/8839:IFITM5 ^@ http://purl.uniprot.org/uniprot/W8W3S8 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/8839:WNT11 ^@ http://purl.uniprot.org/uniprot/A0A8B9SG73 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/8839:B3GALT5 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZD01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8839:ORMDL1 ^@ http://purl.uniprot.org/uniprot/R0KBM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane http://togogenome.org/gene/8839:PPP1R13B ^@ http://purl.uniprot.org/uniprot/A0A8B9TPN8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8839:WNT7A ^@ http://purl.uniprot.org/uniprot/R0LCX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/8839:LOC101803950 ^@ http://purl.uniprot.org/uniprot/R0K8E4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8839:ABCG1 ^@ http://purl.uniprot.org/uniprot/A0A8B9QRZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/8839:CDH5 ^@ http://purl.uniprot.org/uniprot/R0L614 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/8839:GPER1 ^@ http://purl.uniprot.org/uniprot/A0A8B9R2A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:ZDHHC3 ^@ http://purl.uniprot.org/uniprot/A0A8B9SMZ1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/8839:IFIH1 ^@ http://purl.uniprot.org/uniprot/A0A023NCT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/8839:PPP1R1C ^@ http://purl.uniprot.org/uniprot/A0A8B9SRA9 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/8839:LOC101794114 ^@ http://purl.uniprot.org/uniprot/A0A8B9TQX8 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/8839:LOC101797666 ^@ http://purl.uniprot.org/uniprot/R0JJ64 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8839:ID2 ^@ http://purl.uniprot.org/uniprot/R0LU90 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8839:PDGFRA ^@ http://purl.uniprot.org/uniprot/A0A8B9T5H7 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.|||Membrane|||Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.|||Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. http://togogenome.org/gene/8839:HMOX1 ^@ http://purl.uniprot.org/uniprot/A0A172QNS1 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/8839:SYS1 ^@ http://purl.uniprot.org/uniprot/R0L9I0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:CPD ^@ http://purl.uniprot.org/uniprot/Q90240 ^@ Cofactor|||Domain|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the peptidase M14 family.|||Binds 2 Zn(2+) ions per subunit.|||Binds to pre-S, hepatitis B virus large envelope protein, via the carboxypeptidase-like domain.|||Cell membrane|||Expressed in liver, lung, kidney, heart, stomach, pancreas, spleen, gall bladder and intestine, but not in skeletal muscle.|||The N-terminus is blocked.|||There are 3 carboxypeptidase domains. Only the first two domains have any catalytic activity. The first domain preferentially cleaves C-terminal Arg residues, whereas the second preferentially cleaves C-terminal Lys residues. The third domain binds to pre-S, hepatitis B virus large envelope protein. http://togogenome.org/gene/8839:LOC101803851 ^@ http://purl.uniprot.org/uniprot/A0A8B9TSP5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8839:IP6K1 ^@ http://purl.uniprot.org/uniprot/A0A8B9TY83 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/8839:LOC101800358 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZF72 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/8839:HINT1 ^@ http://purl.uniprot.org/uniprot/Q9I839 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/8839:NTS ^@ http://purl.uniprot.org/uniprot/A0A8B9R0V9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurotensin family.|||Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/8839:LOC101804095 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZCR5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8839:EMP2 ^@ http://purl.uniprot.org/uniprot/A0A8B9T340 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Membrane raft|||Nucleus|||perinuclear region http://togogenome.org/gene/8839:ACTB ^@ http://purl.uniprot.org/uniprot/A6ZIB9 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/8839:RNF4 ^@ http://purl.uniprot.org/uniprot/A0A8B9T1V0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8839:ATP6V1G3 ^@ http://purl.uniprot.org/uniprot/A0A8B9SLE0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/8839:NR2F2 ^@ http://purl.uniprot.org/uniprot/A0A8B9TGA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/8839:NR0B2 ^@ http://purl.uniprot.org/uniprot/A0A8B9SK79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8839:SOST ^@ http://purl.uniprot.org/uniprot/A0A8B9SYP6 ^@ Caution|||Similarity ^@ Belongs to the sclerostin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8839:LOC101795199 ^@ http://purl.uniprot.org/uniprot/A0A089RQF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/8839:ALB ^@ http://purl.uniprot.org/uniprot/I6U3L8 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/8839:GLRA2 ^@ http://purl.uniprot.org/uniprot/A0A8B9TQD0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/8839:LOC101802261 ^@ http://purl.uniprot.org/uniprot/R0L6P5 ^@ Similarity ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. http://togogenome.org/gene/8839:PLA2G4A ^@ http://purl.uniprot.org/uniprot/A0A8B9SJF3 ^@ Domain ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding. http://togogenome.org/gene/8839:FABP2 ^@ http://purl.uniprot.org/uniprot/G1FHQ9 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8839:SULT6B1 ^@ http://purl.uniprot.org/uniprot/A0A8B9T4Z3 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/8839:FOXO1 ^@ http://purl.uniprot.org/uniprot/R0LSX8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8839:BRS3 ^@ http://purl.uniprot.org/uniprot/R0JM57 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with C6orf89.|||Membrane http://togogenome.org/gene/8839:KEG62_p09 ^@ http://purl.uniprot.org/uniprot/A6ZJ03|||http://purl.uniprot.org/uniprot/P50655 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase protein 8 family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).|||Mitochondrion membrane http://togogenome.org/gene/8839:ACE2 ^@ http://purl.uniprot.org/uniprot/R0LHX5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M2 family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Cytoplasm|||Membrane|||Secreted|||cilium http://togogenome.org/gene/8839:PKIB ^@ http://purl.uniprot.org/uniprot/R0JZ82 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/8839:SPOCK1 ^@ http://purl.uniprot.org/uniprot/A0A8B9TTZ1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8839:TLR4 ^@ http://purl.uniprot.org/uniprot/G8FUB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/8839:CSGALNACT1 ^@ http://purl.uniprot.org/uniprot/R0L7C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/8839:HCRTR2 ^@ http://purl.uniprot.org/uniprot/R0KET9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:LRP8 ^@ http://purl.uniprot.org/uniprot/I6VXR2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8839:DCP1B ^@ http://purl.uniprot.org/uniprot/R0KCP9 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/8839:LOC101792171 ^@ http://purl.uniprot.org/uniprot/A0A8B9T535 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:KEG62_p13 ^@ http://purl.uniprot.org/uniprot/A6ZIZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 1 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8839:LOC101803171 ^@ http://purl.uniprot.org/uniprot/R0LKG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:TEF ^@ http://purl.uniprot.org/uniprot/A0A8B9QYT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/8839:FBLN5 ^@ http://purl.uniprot.org/uniprot/A0A8B9SRD4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8839:GEM ^@ http://purl.uniprot.org/uniprot/R0KL90 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/8839:LOC101794349 ^@ http://purl.uniprot.org/uniprot/A0A8B9QYW3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/8839:UBE3A ^@ http://purl.uniprot.org/uniprot/A0A8B9QVL0|||http://purl.uniprot.org/uniprot/A0A8B9R429 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.|||Nucleus http://togogenome.org/gene/8839:GPX8 ^@ http://purl.uniprot.org/uniprot/R0L669 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/8839:SLC15A1 ^@ http://purl.uniprot.org/uniprot/A0A088MTY4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Interacts (via extracellular domain region) with trypsin.|||Membrane http://togogenome.org/gene/8839:SLC34A2 ^@ http://purl.uniprot.org/uniprot/A0A8B9TMR3|||http://purl.uniprot.org/uniprot/R0L7I2 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:LOC101791108 ^@ http://purl.uniprot.org/uniprot/R0L2K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/8839:NTNG1 ^@ http://purl.uniprot.org/uniprot/R0L0R7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8839:TXK ^@ http://purl.uniprot.org/uniprot/A0A8B9ZHS1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/8839:LOC101800121 ^@ http://purl.uniprot.org/uniprot/A0A8B9TVX5 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.|||Cell membrane|||Endosome membrane|||Golgi apparatus membrane|||Interacts with NEDD4 and NEDD4L.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8839:GPR6 ^@ http://purl.uniprot.org/uniprot/A0A8E7PED9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:MYOD1 ^@ http://purl.uniprot.org/uniprot/C3U0I1 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/8839:TAC1 ^@ http://purl.uniprot.org/uniprot/A0A8B9R0S2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted|||Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. http://togogenome.org/gene/8839:RECQL ^@ http://purl.uniprot.org/uniprot/A0A8B9QPF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RecQ subfamily.|||Nucleus http://togogenome.org/gene/8839:HOXD12 ^@ http://purl.uniprot.org/uniprot/A0A8B9SJV5|||http://purl.uniprot.org/uniprot/R0LVC1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8839:FAM118B ^@ http://purl.uniprot.org/uniprot/A0A8B9TAN4 ^@ Similarity ^@ Belongs to the FAM118 family. http://togogenome.org/gene/8839:ZFX ^@ http://purl.uniprot.org/uniprot/A0A8B9T2X2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8839:GRIN2B ^@ http://purl.uniprot.org/uniprot/R0M229 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/8839:FZD4 ^@ http://purl.uniprot.org/uniprot/R0JEY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:LOC101795933 ^@ http://purl.uniprot.org/uniprot/A0A3G2VSX8 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/8839:SFRP2 ^@ http://purl.uniprot.org/uniprot/C7AFG0|||http://purl.uniprot.org/uniprot/R0L3X7 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8839:ST6GAL2 ^@ http://purl.uniprot.org/uniprot/A0A8B9QRS5|||http://purl.uniprot.org/uniprot/R0M1I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8839:GH1 ^@ http://purl.uniprot.org/uniprot/P11228|||http://purl.uniprot.org/uniprot/Q549W9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Growth hormone plays an important role in growth control.|||Secreted http://togogenome.org/gene/8839:MAFG ^@ http://purl.uniprot.org/uniprot/R0LZB5 ^@ Similarity ^@ Belongs to the bZIP family. Maf subfamily. http://togogenome.org/gene/8839:MBOAT4 ^@ http://purl.uniprot.org/uniprot/A0A8B9SGV1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:MED9 ^@ http://purl.uniprot.org/uniprot/R0KC06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 9 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/8839:RAB9A ^@ http://purl.uniprot.org/uniprot/R0LG13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||phagosome membrane http://togogenome.org/gene/8839:LOC101795398 ^@ http://purl.uniprot.org/uniprot/L7X0M5 ^@ Similarity ^@ Belongs to the LECT2/MIM-1 family. http://togogenome.org/gene/8839:ENTPD1 ^@ http://purl.uniprot.org/uniprot/A0A8B9TQS8 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/8839:TECR ^@ http://purl.uniprot.org/uniprot/A0A8B9T559 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Membrane http://togogenome.org/gene/8839:STK38L ^@ http://purl.uniprot.org/uniprot/A0A8B9SPQ8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8839:KCNMB1 ^@ http://purl.uniprot.org/uniprot/R0LAZ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:NPBWR2 ^@ http://purl.uniprot.org/uniprot/A0A8B9T8H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:CNOT6 ^@ http://purl.uniprot.org/uniprot/R0L9D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCR4/nocturin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8839:SPP2 ^@ http://purl.uniprot.org/uniprot/A0A386GZQ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPP2 family.|||Could coordinate an aspect of bone turnover.|||Secreted http://togogenome.org/gene/8839:GIMD1 ^@ http://purl.uniprot.org/uniprot/R0L6C2 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/8839:LOC101798542 ^@ http://purl.uniprot.org/uniprot/R0LY36 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/8839:LOC101802825 ^@ http://purl.uniprot.org/uniprot/A0A8B9SSG6 ^@ Similarity ^@ Belongs to the intercrine gamma family. http://togogenome.org/gene/8839:RPS6KA3 ^@ http://purl.uniprot.org/uniprot/A0A8B9T3Q9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/8839:CHRNA9 ^@ http://purl.uniprot.org/uniprot/A0A8B9TKP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8839:HAPLN1 ^@ http://purl.uniprot.org/uniprot/R0K8V6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8839:PLIN1 ^@ http://purl.uniprot.org/uniprot/F6KFT3 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/8839:GGT1 ^@ http://purl.uniprot.org/uniprot/A0A8B9R6I1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyltransferase family.|||Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.|||Membrane http://togogenome.org/gene/8839:LOC101800257 ^@ http://purl.uniprot.org/uniprot/A0A8B9QQA0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/8839:KEG62_p05 ^@ http://purl.uniprot.org/uniprot/A6ZJ07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4L family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8839:GALNT18 ^@ http://purl.uniprot.org/uniprot/A0A8B9SUI9|||http://purl.uniprot.org/uniprot/A0A8B9SUL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8839:B3GNT2 ^@ http://purl.uniprot.org/uniprot/R0JVT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8839:GJC2 ^@ http://purl.uniprot.org/uniprot/R0JLL8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8839:S1PR4 ^@ http://purl.uniprot.org/uniprot/A0A8B9ST54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:DNAAF6 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZKV3 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/8839:BRINP3 ^@ http://purl.uniprot.org/uniprot/R0M2X6 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/8839:ENO1 ^@ http://purl.uniprot.org/uniprot/P19140 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the enolase family.|||Binds two Mg(2+) per subunit. Required for catalysis and for stabilizing the dimer.|||Both an enzyme and a lens structural protein.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/8839:PKIG ^@ http://purl.uniprot.org/uniprot/A0A8B9T269 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/8839:SULF2 ^@ http://purl.uniprot.org/uniprot/A0A8B9SZZ0 ^@ Cofactor|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Binds 1 Ca(2+) ion per subunit.|||Cell surface|||Endoplasmic reticulum|||Golgi stack|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/8839:CD2 ^@ http://purl.uniprot.org/uniprot/A0A8B9TJC2|||http://purl.uniprot.org/uniprot/A0A8B9TLB4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:RHBDF1 ^@ http://purl.uniprot.org/uniprot/A0A8B9TX08|||http://purl.uniprot.org/uniprot/R0JDL0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. http://togogenome.org/gene/8839:UTS2B ^@ http://purl.uniprot.org/uniprot/A0A8B9T8J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urotensin-2 family.|||Secreted http://togogenome.org/gene/8839:MSTN ^@ http://purl.uniprot.org/uniprot/R0KAD8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Secreted http://togogenome.org/gene/8839:CFLAR ^@ http://purl.uniprot.org/uniprot/A0A8B9T0L2 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/8839:MRRF ^@ http://purl.uniprot.org/uniprot/A0A8B9TK29 ^@ Function|||Similarity ^@ Belongs to the RRF family.|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/8839:LOC101797566 ^@ http://purl.uniprot.org/uniprot/R0KFP7 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/8839:HOXA11 ^@ http://purl.uniprot.org/uniprot/A0A8B9QTJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/8839:SLC7A1 ^@ http://purl.uniprot.org/uniprot/A0A088MGN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:RCAN1 ^@ http://purl.uniprot.org/uniprot/R0K6W3 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/8839:SKI ^@ http://purl.uniprot.org/uniprot/R0M4F9 ^@ Similarity ^@ Belongs to the SKI family. http://togogenome.org/gene/8839:CHRM3 ^@ http://purl.uniprot.org/uniprot/A0A8B9SMB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/8839:CLDN18 ^@ http://purl.uniprot.org/uniprot/R0L7C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/8839:B3GNT5 ^@ http://purl.uniprot.org/uniprot/A0A8B9TQ03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8839:LOC101793815 ^@ http://purl.uniprot.org/uniprot/A0A8B9R2I9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/8839:FUT9 ^@ http://purl.uniprot.org/uniprot/R0JS59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/8839:ACTN2 ^@ http://purl.uniprot.org/uniprot/R0JMH7 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/8839:POU1F1 ^@ http://purl.uniprot.org/uniprot/A0A8X0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/8839:LOC101804267 ^@ http://purl.uniprot.org/uniprot/A0A8B9R7M0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8839:DDC ^@ http://purl.uniprot.org/uniprot/R0LFC9 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/8839:F13A1 ^@ http://purl.uniprot.org/uniprot/R0KCX2 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/8839:NLGN1 ^@ http://purl.uniprot.org/uniprot/A0A8B9TNM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:LOC101801612 ^@ http://purl.uniprot.org/uniprot/A0A8B9R5V6 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/8839:LPIN1 ^@ http://purl.uniprot.org/uniprot/A0A8B9SG69 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/8839:STIM2 ^@ http://purl.uniprot.org/uniprot/A0A8B9TK12 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:SLCO5A1 ^@ http://purl.uniprot.org/uniprot/R0L7E6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/8839:LOC101795602 ^@ http://purl.uniprot.org/uniprot/A0A8B9TK09 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/8839:TMEM229B ^@ http://purl.uniprot.org/uniprot/R0JPG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM229 family.|||Membrane http://togogenome.org/gene/8839:LIPA ^@ http://purl.uniprot.org/uniprot/A0A8B9ZHY0 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/8839:NOS2 ^@ http://purl.uniprot.org/uniprot/F0UYP7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NOS family.|||Binds 1 FAD.|||Binds 1 FMN.|||Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. http://togogenome.org/gene/8839:PPP2R2B ^@ http://purl.uniprot.org/uniprot/A0A8B9TB29|||http://purl.uniprot.org/uniprot/A0A8B9ZHU3 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/8839:LOC101794702 ^@ http://purl.uniprot.org/uniprot/A0A8B9TUS5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 2H phosphoesterase superfamily. CNPase family.|||Exists as monomers and homodimers.|||May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.|||Melanosome|||Membrane http://togogenome.org/gene/8839:LOC101801566 ^@ http://purl.uniprot.org/uniprot/A0A8B9T9A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/8839:GFRA1 ^@ http://purl.uniprot.org/uniprot/A0A8B9SPA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GDNFR family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:VDAC3 ^@ http://purl.uniprot.org/uniprot/A0A8B9T595 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/8839:WNT3 ^@ http://purl.uniprot.org/uniprot/A0A8B9QYQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/8839:CDR2L ^@ http://purl.uniprot.org/uniprot/A0A8B9SVN3 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/8839:ST3GAL1 ^@ http://purl.uniprot.org/uniprot/R0M5M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8839:MB21D2 ^@ http://purl.uniprot.org/uniprot/R0JBC9 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/8839:MEOX1 ^@ http://purl.uniprot.org/uniprot/A0A8B9SY94 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8839:HOXB8 ^@ http://purl.uniprot.org/uniprot/A0A8B9QYE4|||http://purl.uniprot.org/uniprot/R0L5D3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8839:EXOC1 ^@ http://purl.uniprot.org/uniprot/A0A8B9T5E8 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/8839:DUSP29 ^@ http://purl.uniprot.org/uniprot/A0A8B9TGB6 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/8839:P2RX7 ^@ http://purl.uniprot.org/uniprot/A0A8B9T9J3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P2X receptor family.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/8839:CCR6 ^@ http://purl.uniprot.org/uniprot/A0A8B9QT21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/8839:PRPF38B ^@ http://purl.uniprot.org/uniprot/R0L434 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||May be required for pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/8839:HEATR5B ^@ http://purl.uniprot.org/uniprot/R0JPU4 ^@ Similarity ^@ Belongs to the HEATR5 family. http://togogenome.org/gene/8839:TLL1 ^@ http://purl.uniprot.org/uniprot/A0A8B9SGP9 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8839:SLC7A9 ^@ http://purl.uniprot.org/uniprot/A0A088MKB1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:LOC106018249 ^@ http://purl.uniprot.org/uniprot/A0A0C4WTG8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8839:RFTN2 ^@ http://purl.uniprot.org/uniprot/R0LDK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:PRPH2 ^@ http://purl.uniprot.org/uniprot/R0K469 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/8839:SYN3 ^@ http://purl.uniprot.org/uniprot/A0A8B9TT72 ^@ Similarity ^@ Belongs to the synapsin family. http://togogenome.org/gene/8839:LOC101802686 ^@ http://purl.uniprot.org/uniprot/A0A8B9TKX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane http://togogenome.org/gene/8839:TNFSF13B ^@ http://purl.uniprot.org/uniprot/Q0QCV8 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/8839:ADSL ^@ http://purl.uniprot.org/uniprot/K9LGB5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/8839:LOC101792898 ^@ http://purl.uniprot.org/uniprot/A0A8B9SZL1 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/8839:HOXB3 ^@ http://purl.uniprot.org/uniprot/R0L5D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/8839:CCNI ^@ http://purl.uniprot.org/uniprot/A0A8B9SJ09 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/8839:MRPL20 ^@ http://purl.uniprot.org/uniprot/R0M552 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family. http://togogenome.org/gene/8839:NSFL1C ^@ http://purl.uniprot.org/uniprot/R0KV36 ^@ Subcellular Location Annotation ^@ Golgi stack http://togogenome.org/gene/8839:IL10RB ^@ http://purl.uniprot.org/uniprot/L7X844 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tissue factor family.|||Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.|||Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. http://togogenome.org/gene/8839:GJA1 ^@ http://purl.uniprot.org/uniprot/R0LB91 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8839:HOXB6 ^@ http://purl.uniprot.org/uniprot/A0A8B9QYM4|||http://purl.uniprot.org/uniprot/R0JHZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/8839:LOC101797113 ^@ http://purl.uniprot.org/uniprot/R0LQE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/8839:CDPF1 ^@ http://purl.uniprot.org/uniprot/R0LRD9 ^@ Similarity ^@ Belongs to the CDPF1 family. http://togogenome.org/gene/8839:PPARGC1A ^@ http://purl.uniprot.org/uniprot/A0A8B9TLU8 ^@ Subcellular Location Annotation ^@ PML body http://togogenome.org/gene/8839:SLC24A5 ^@ http://purl.uniprot.org/uniprot/S4SXD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/8839:TLR-15 ^@ http://purl.uniprot.org/uniprot/J7FJ07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/8839:ADORA2A ^@ http://purl.uniprot.org/uniprot/A0A8B9SHX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/8839:KEG62_p07 ^@ http://purl.uniprot.org/uniprot/Q0ZA04 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane http://togogenome.org/gene/8839:A1CF ^@ http://purl.uniprot.org/uniprot/R0JZB9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8839:LOC101799801 ^@ http://purl.uniprot.org/uniprot/A0A8B9QL37 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/8839:CAPN6 ^@ http://purl.uniprot.org/uniprot/R0LVR4 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/8839:DLGAP1 ^@ http://purl.uniprot.org/uniprot/R0LSN8 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/8839:SLC20A2 ^@ http://purl.uniprot.org/uniprot/R0JJB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/8839:LOC101793992 ^@ http://purl.uniprot.org/uniprot/R0LM15 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/8839:SERPINA10 ^@ http://purl.uniprot.org/uniprot/A0A8B9SQL8 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8839:IFITM2 ^@ http://purl.uniprot.org/uniprot/A0A0C4K5J8 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/8839:PCK1 ^@ http://purl.uniprot.org/uniprot/R0LQQ0 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. http://togogenome.org/gene/8839:FSHB ^@ http://purl.uniprot.org/uniprot/Q0ZR38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/8839:PCBD1 ^@ http://purl.uniprot.org/uniprot/A0A8B9SN49 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/8839:INO80 ^@ http://purl.uniprot.org/uniprot/A0A8B9QS26 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.|||Belongs to the SNF2/RAD54 helicase family.|||Component of the INO80 chromatin-remodeling complex.|||Nucleus|||The DBINO region is involved in binding to DNA. http://togogenome.org/gene/8839:KCNJ3 ^@ http://purl.uniprot.org/uniprot/R0KE04 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.|||Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.|||Membrane|||This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. http://togogenome.org/gene/8839:FGF7 ^@ http://purl.uniprot.org/uniprot/R0LIH0 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8839:LOC101801984 ^@ http://purl.uniprot.org/uniprot/R0JS98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/8839:GDAP2 ^@ http://purl.uniprot.org/uniprot/A0A8B9Z8I7 ^@ Similarity ^@ Belongs to the GDAP2 family. http://togogenome.org/gene/8839:SMAD5 ^@ http://purl.uniprot.org/uniprot/A0A8B9TUN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8839:RPF2 ^@ http://purl.uniprot.org/uniprot/A0A8B9SUP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/8839:SEMA3E ^@ http://purl.uniprot.org/uniprot/R0LRL3 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8839:TM4SF18 ^@ http://purl.uniprot.org/uniprot/A0A8B9R087 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/8839:ANTXRL ^@ http://purl.uniprot.org/uniprot/A0A8B9TDV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATR family.|||Membrane http://togogenome.org/gene/8839:TNFAIP6 ^@ http://purl.uniprot.org/uniprot/R0M6H9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8839:FZD10 ^@ http://purl.uniprot.org/uniprot/A0A8B9T6D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Membrane http://togogenome.org/gene/8839:LOC101805249 ^@ http://purl.uniprot.org/uniprot/A0A0C5B1C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:PTAFR ^@ http://purl.uniprot.org/uniprot/A0A8B9TFD8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ARRB1.|||Membrane http://togogenome.org/gene/8839:MIGA2 ^@ http://purl.uniprot.org/uniprot/R0LVY4 ^@ Similarity ^@ Belongs to the mitoguardin family. http://togogenome.org/gene/8839:HAL ^@ http://purl.uniprot.org/uniprot/R0LGR4 ^@ Similarity ^@ Belongs to the PAL/histidase family. http://togogenome.org/gene/8839:HAUS3 ^@ http://purl.uniprot.org/uniprot/A0A8B9T2B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS3 family.|||spindle http://togogenome.org/gene/8839:CCDC181 ^@ http://purl.uniprot.org/uniprot/R0JHX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC181 family.|||Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.|||cytoskeleton http://togogenome.org/gene/8839:SMPX ^@ http://purl.uniprot.org/uniprot/A0A8B9ZG25 ^@ Function|||Similarity ^@ Belongs to the SMPX family.|||Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. http://togogenome.org/gene/8839:LOC101791705 ^@ http://purl.uniprot.org/uniprot/K7WPA4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8839:YPEL5 ^@ http://purl.uniprot.org/uniprot/R0JQY4 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/8839:SPSB1 ^@ http://purl.uniprot.org/uniprot/R0LRP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Cytoplasm http://togogenome.org/gene/8839:FASN ^@ http://purl.uniprot.org/uniprot/A0A0D3LZ43 ^@ Function ^@ Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. http://togogenome.org/gene/8839:RHO ^@ http://purl.uniprot.org/uniprot/A0A8B9TPD2 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Contains one covalently linked retinal chromophore.|||Membrane http://togogenome.org/gene/8839:NFYA ^@ http://purl.uniprot.org/uniprot/A0A8B9TR73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NFYA/HAP2 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.|||Heterotrimer.|||Nucleus http://togogenome.org/gene/8839:FGF13 ^@ http://purl.uniprot.org/uniprot/R0KY24 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8839:TGM4 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZBF7 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/8839:LOC101796052 ^@ http://purl.uniprot.org/uniprot/A0A089G6D2|||http://purl.uniprot.org/uniprot/A0A915Y4P7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Has antiviral activities.|||Secreted http://togogenome.org/gene/8839:TAT ^@ http://purl.uniprot.org/uniprot/R0KNP9 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer. http://togogenome.org/gene/8839:MAPK1 ^@ http://purl.uniprot.org/uniprot/A0A076G731 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/8839:CCL20 ^@ http://purl.uniprot.org/uniprot/A0A8B9TB73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/8839:PPARA ^@ http://purl.uniprot.org/uniprot/A0A8B9SM95|||http://purl.uniprot.org/uniprot/A5HJM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/8839:CRYZ ^@ http://purl.uniprot.org/uniprot/R0JVP4 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/8839:PLIN2 ^@ http://purl.uniprot.org/uniprot/A9YVJ0 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/8839:FIGNL1 ^@ http://purl.uniprot.org/uniprot/R0JPA3 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/8839:EZH2 ^@ http://purl.uniprot.org/uniprot/A0A8B9T753 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8839:CACNG2 ^@ http://purl.uniprot.org/uniprot/R0K2U7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. http://togogenome.org/gene/8839:DPT ^@ http://purl.uniprot.org/uniprot/R0KYN8 ^@ Similarity ^@ Belongs to the dermatopontin family. http://togogenome.org/gene/8839:RPS7 ^@ http://purl.uniprot.org/uniprot/A0A8B9SIY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eS7 family.|||centrosome http://togogenome.org/gene/8839:CPT1A ^@ http://purl.uniprot.org/uniprot/R0L018 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/8839:NOL10 ^@ http://purl.uniprot.org/uniprot/A0A8B9QWB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat NOL10/ENP2 family.|||nucleolus http://togogenome.org/gene/8839:STX19 ^@ http://purl.uniprot.org/uniprot/R0LLM7 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/8839:CHST1 ^@ http://purl.uniprot.org/uniprot/R0LID9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/8839:DCLRE1A ^@ http://purl.uniprot.org/uniprot/R0LHF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/8839:GPR65 ^@ http://purl.uniprot.org/uniprot/A0A8B9SLI5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8839:PARK7 ^@ http://purl.uniprot.org/uniprot/R0KXC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C56 family.|||Membrane raft http://togogenome.org/gene/8839:GJA4 ^@ http://purl.uniprot.org/uniprot/R0JIT1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8839:CNRIP1 ^@ http://purl.uniprot.org/uniprot/R0L7A2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CNRIP family.|||Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.|||Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. http://togogenome.org/gene/8839:LOC101797182 ^@ http://purl.uniprot.org/uniprot/A0A8B9R125 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8839:DDT ^@ http://purl.uniprot.org/uniprot/R0LA79 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/8839:ELOVL5 ^@ http://purl.uniprot.org/uniprot/A0A068C605 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL5 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||dendrite http://togogenome.org/gene/8839:ZMPSTE24 ^@ http://purl.uniprot.org/uniprot/A0A8B9TGF7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48A family.|||Binds 1 zinc ion per subunit.|||Endoplasmic reticulum membrane|||Proteolytically removes the C-terminal three residues of farnesylated proteins. http://togogenome.org/gene/8839:TAFA4 ^@ http://purl.uniprot.org/uniprot/A0A8B9TG61 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/8839:LOC101790517 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZI60 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/8839:LOC101795838 ^@ http://purl.uniprot.org/uniprot/R0JVT9 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/8839:SAA2 ^@ http://purl.uniprot.org/uniprot/P02740 ^@ Disease Annotation|||Function|||Induction|||PTM|||Polymorphism|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ At least two alleles exist. The sequence of the B allele is shown here.|||Belongs to the SAA family.|||Expressed by the liver; secreted in plasma. Also present in the liver and lung irrespective of induction.|||Major acute phase reactant. Apolipoprotein of the HDL complex.|||Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.|||Secreted|||This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 3 residues from the C-terminal end.|||Upon cytokine stimulation. http://togogenome.org/gene/8839:MRPS17 ^@ http://purl.uniprot.org/uniprot/R0KD36 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/8839:RIPOR2 ^@ http://purl.uniprot.org/uniprot/A0A8B9SU96 ^@ Similarity ^@ Belongs to the RIPOR family. http://togogenome.org/gene/8839:DHRS9 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZGN4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8839:MAT1A ^@ http://purl.uniprot.org/uniprot/R0LR17 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/8839:DRD1 ^@ http://purl.uniprot.org/uniprot/I6Q8X7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:GPR87 ^@ http://purl.uniprot.org/uniprot/A0A8B9TJJ8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8839:CMBL ^@ http://purl.uniprot.org/uniprot/R0L8L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/8839:PLAU ^@ http://purl.uniprot.org/uniprot/A0A8B9ZI57 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8839:GOLGA5 ^@ http://purl.uniprot.org/uniprot/R0JRZ4 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. http://togogenome.org/gene/8839:TLR7 ^@ http://purl.uniprot.org/uniprot/A9X7P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Endoplasmic reticulum membrane|||Lysosome|||Membrane|||phagosome http://togogenome.org/gene/8839:NCF2 ^@ http://purl.uniprot.org/uniprot/A0A8B9Z8G3 ^@ Similarity ^@ Belongs to the NCF2/NOXA1 family. http://togogenome.org/gene/8839:LOC101793166 ^@ http://purl.uniprot.org/uniprot/Q38HW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/8839:TLR1-A ^@ http://purl.uniprot.org/uniprot/M9NJN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/8839:BMP4 ^@ http://purl.uniprot.org/uniprot/A5HMF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/8839:KEG62_p03 ^@ http://purl.uniprot.org/uniprot/A6ZJ09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 5 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8839:YPEL2 ^@ http://purl.uniprot.org/uniprot/A0A8B9TSM1 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/8839:TTC39C ^@ http://purl.uniprot.org/uniprot/A0A8B9SPR2 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/8839:CACNB2 ^@ http://purl.uniprot.org/uniprot/A0A8B9SFE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||sarcolemma http://togogenome.org/gene/8839:NTRK3 ^@ http://purl.uniprot.org/uniprot/A0A8B9SGX7|||http://purl.uniprot.org/uniprot/A0A8B9SGY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/8839:FGF9 ^@ http://purl.uniprot.org/uniprot/R0J7C8 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8839:LOC101802312 ^@ http://purl.uniprot.org/uniprot/A0A8B9QKT2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/8839:GPR1 ^@ http://purl.uniprot.org/uniprot/A0A8B9QTU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:UBL3 ^@ http://purl.uniprot.org/uniprot/A0A8B9R0E7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8839:FAR2 ^@ http://purl.uniprot.org/uniprot/A0A8B9SK50 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acyl-CoA reductase family.|||Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.|||Peroxisome membrane http://togogenome.org/gene/8839:HOXD11 ^@ http://purl.uniprot.org/uniprot/A0A8B9SJX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/8839:RGS4 ^@ http://purl.uniprot.org/uniprot/A0A8B9TFY3 ^@ Function ^@ Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. http://togogenome.org/gene/8839:NDC80 ^@ http://purl.uniprot.org/uniprot/A0A8B9TRY7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NDC80/HEC1 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/8839:NADK ^@ http://purl.uniprot.org/uniprot/A0A8B9THS8 ^@ Similarity ^@ Belongs to the NAD kinase family. http://togogenome.org/gene/8839:TBC1D7 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZJY2 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Vesicle http://togogenome.org/gene/8839:PDE8A ^@ http://purl.uniprot.org/uniprot/A0A8B9ZKR9 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/8839:PDE6H ^@ http://purl.uniprot.org/uniprot/A0A8B9R0J7 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/8839:LOC101791292 ^@ http://purl.uniprot.org/uniprot/A0A8B9T8F3|||http://purl.uniprot.org/uniprot/A0A8B9TA28 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/8839:FAM167A ^@ http://purl.uniprot.org/uniprot/R0KZW7 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/8839:LOC101792344 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZKT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:PTGFR ^@ http://purl.uniprot.org/uniprot/R0KCM1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8839:LOC101797297 ^@ http://purl.uniprot.org/uniprot/A0A8B9TBU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/8839:IL15 ^@ http://purl.uniprot.org/uniprot/A0A7S9TS10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/8839:LOC101804644 ^@ http://purl.uniprot.org/uniprot/R0LH27 ^@ Similarity ^@ Belongs to the TFIIE alpha subunit family. http://togogenome.org/gene/8839:ABCC9 ^@ http://purl.uniprot.org/uniprot/A0A8B9SRM1 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with KCNJ11.|||Membrane http://togogenome.org/gene/8839:TH ^@ http://purl.uniprot.org/uniprot/R0JUR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.|||axon|||perinuclear region http://togogenome.org/gene/8839:F2RL3 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZJV4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8839:KBP ^@ http://purl.uniprot.org/uniprot/Q90218 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Postsynaptic cell membrane|||Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists (By similarity). http://togogenome.org/gene/8839:ZEB2 ^@ http://purl.uniprot.org/uniprot/A0A8B9T699 ^@ Similarity ^@ Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. http://togogenome.org/gene/8839:LOC101797138 ^@ http://purl.uniprot.org/uniprot/R0KET6 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/8839:GRPR ^@ http://purl.uniprot.org/uniprot/R0K6D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:TAFA1 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZHZ8 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/8839:SEMA3C ^@ http://purl.uniprot.org/uniprot/A0A8B9R497 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/8839:BRD1 ^@ http://purl.uniprot.org/uniprot/R0L443 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8839:RBP7 ^@ http://purl.uniprot.org/uniprot/R0L522 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8839:ANAPC13 ^@ http://purl.uniprot.org/uniprot/R0JW70 ^@ Function|||Similarity ^@ Belongs to the APC13 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. http://togogenome.org/gene/8839:PABIR2 ^@ http://purl.uniprot.org/uniprot/A0A8B9T849 ^@ Similarity ^@ Belongs to the FAM122 family. http://togogenome.org/gene/8839:LSM14A ^@ http://purl.uniprot.org/uniprot/A0A023PUY5 ^@ Similarity ^@ Belongs to the LSM14 family. http://togogenome.org/gene/8839:LHFPL2 ^@ http://purl.uniprot.org/uniprot/R0M4R0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:CTSK ^@ http://purl.uniprot.org/uniprot/A0A8B9ZGA0 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/8839:KEG62_p10 ^@ http://purl.uniprot.org/uniprot/A6ZJ02|||http://purl.uniprot.org/uniprot/P98019 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Binds a dinuclear copper A center per subunit.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16 (By similarity).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8839:SLC16A12 ^@ http://purl.uniprot.org/uniprot/R0JB22 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:TMEM126A ^@ http://purl.uniprot.org/uniprot/R0LJC4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:CCL26 ^@ http://purl.uniprot.org/uniprot/Q4VSK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/8839:ERGIC2 ^@ http://purl.uniprot.org/uniprot/A0A8B9SXP4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/8839:SEC23A ^@ http://purl.uniprot.org/uniprot/R0L318 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/8839:GSN ^@ http://purl.uniprot.org/uniprot/R0L173 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the villin/gelsolin family.|||Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.|||cytoskeleton http://togogenome.org/gene/8839:CETP ^@ http://purl.uniprot.org/uniprot/S4SLP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Secreted http://togogenome.org/gene/8839:CASP3 ^@ http://purl.uniprot.org/uniprot/A0A8B9SSZ4 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/8839:OGN ^@ http://purl.uniprot.org/uniprot/R0L6G4 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/8839:CA7 ^@ http://purl.uniprot.org/uniprot/A0A8B9SKU2 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/8839:SPECC1L ^@ http://purl.uniprot.org/uniprot/A0A8B9QZM4|||http://purl.uniprot.org/uniprot/R0KYM2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytospin-A family.|||Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.|||May interact with both microtubules and actin cytoskeleton.|||cytoskeleton|||gap junction|||spindle http://togogenome.org/gene/8839:IL8 ^@ http://purl.uniprot.org/uniprot/Q0WZB5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Homodimer.|||Secreted http://togogenome.org/gene/8839:FAM120B ^@ http://purl.uniprot.org/uniprot/A0A8B9SGK3 ^@ Similarity ^@ Belongs to the constitutive coactivator of PPAR-gamma family. http://togogenome.org/gene/8839:EHD4 ^@ http://purl.uniprot.org/uniprot/R0J902 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/8839:NR1H3 ^@ http://purl.uniprot.org/uniprot/C5IUM7|||http://purl.uniprot.org/uniprot/R0KNX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/8839:IL10 ^@ http://purl.uniprot.org/uniprot/I6N8I3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/8839:EXTL2 ^@ http://purl.uniprot.org/uniprot/A0A8B9TLH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/8839:NFYB ^@ http://purl.uniprot.org/uniprot/A0A8B9TXA9 ^@ Function|||Similarity ^@ Belongs to the NFYB/HAP3 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. http://togogenome.org/gene/8839:PTH ^@ http://purl.uniprot.org/uniprot/A0A8B9T173 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the parathyroid hormone family.|||PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.|||Secreted http://togogenome.org/gene/8839:TRAF3 ^@ http://purl.uniprot.org/uniprot/R0JSP4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8839:ADCY7 ^@ http://purl.uniprot.org/uniprot/A0A8B9QZN7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/8839:CYGB ^@ http://purl.uniprot.org/uniprot/R0K683 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/8839:LOC101795902 ^@ http://purl.uniprot.org/uniprot/A0A8B9R150 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/8839:HSPA2 ^@ http://purl.uniprot.org/uniprot/B2ZP77 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/8839:LOC101795539 ^@ http://purl.uniprot.org/uniprot/A0A8B9TBT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/8839:LOC101802760 ^@ http://purl.uniprot.org/uniprot/A0A0C4WVM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:LOC101791691 ^@ http://purl.uniprot.org/uniprot/R0M3S3 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/8839:TNFSF8 ^@ http://purl.uniprot.org/uniprot/A0A8B9TNY3 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/8839:RCAN2 ^@ http://purl.uniprot.org/uniprot/R0KKK3 ^@ Function|||Similarity ^@ Belongs to the RCAN family.|||Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. http://togogenome.org/gene/8839:KEG62_p08 ^@ http://purl.uniprot.org/uniprot/A6ZJ04 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/8839:HOXD10 ^@ http://purl.uniprot.org/uniprot/A0A8B9SJS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/8839:SLC6A19 ^@ http://purl.uniprot.org/uniprot/A0A088MGN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/8839:ARMC1 ^@ http://purl.uniprot.org/uniprot/R0L473 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/8839:GPHB5 ^@ http://purl.uniprot.org/uniprot/R0JNV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/8839:HOXD4 ^@ http://purl.uniprot.org/uniprot/A0A8B9SJM7|||http://purl.uniprot.org/uniprot/R0K7E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/8839:LDAH ^@ http://purl.uniprot.org/uniprot/A0A8B9QUF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. LDAH family.|||Lipid droplet http://togogenome.org/gene/8839:FTH1 ^@ http://purl.uniprot.org/uniprot/P80145 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the ferritin family.|||By duck hepatitis virus type I (DHV-1) (PubMed:24981929). By polyinosinic:polycytidylic acid (poly I:C) which mimicks viral double-stranded RNA (PubMed:1499559).|||Cytoplasm|||Expressed in erythroblasts (at protein level) (PubMed:1499559). Expressed in heart, liver, spleen, lung, kidney, large intestine, small intestine, muscle, glandular stomach, ovary and oviduct (PubMed:24981929).|||Inhibits translation of various mRNA species in vitro. Associates with a 35S prosome-like particle that contains non-translated mRNAs in a complex with proteins. May be involved in pre-translational regulation of some mRNA.|||Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. http://togogenome.org/gene/8839:LOC101804190 ^@ http://purl.uniprot.org/uniprot/A0A8B9TQH4 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/8839:GNPDA2 ^@ http://purl.uniprot.org/uniprot/A0A8B9QR64 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/8839:CAV3 ^@ http://purl.uniprot.org/uniprot/D7RF71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/8839:KEG62_p01 ^@ http://purl.uniprot.org/uniprot/A6ZJ11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 6 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion membrane http://togogenome.org/gene/8839:ASL ^@ http://purl.uniprot.org/uniprot/P24057 ^@ Function|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.|||Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. Despite possessing the necessary catalytic residues, this protein does not function as an enzymatically active argininosuccinate lyase.|||Eye lens.|||Homotetramer. http://togogenome.org/gene/8839:DOCK2 ^@ http://purl.uniprot.org/uniprot/A0A8B9T599 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/8839:SLA ^@ http://purl.uniprot.org/uniprot/A0A8B9TBV5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8839:LOC101795858 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZGT4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8839:PDCL ^@ http://purl.uniprot.org/uniprot/R0JBI8 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/8839:ADIPOR1 ^@ http://purl.uniprot.org/uniprot/Q09LK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/8839:STXBP3 ^@ http://purl.uniprot.org/uniprot/A0A8B9SJ47 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/8839:PRPF3 ^@ http://purl.uniprot.org/uniprot/R0KYC6 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). http://togogenome.org/gene/8839:FBXO32 ^@ http://purl.uniprot.org/uniprot/E5FXJ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8839:KEG62_p02 ^@ http://purl.uniprot.org/uniprot/A6ZJ10 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome b family.|||Binds 2 heme groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8839:NT5C3A ^@ http://purl.uniprot.org/uniprot/A0A8B9ZKJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/8839:CLDN14 ^@ http://purl.uniprot.org/uniprot/R0LWV6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/8839:RPRD1A ^@ http://purl.uniprot.org/uniprot/A0A8B9SGM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.|||Nucleus http://togogenome.org/gene/8839:LOC101798172 ^@ http://purl.uniprot.org/uniprot/A0A8B9R0U8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/8839:TADA2A ^@ http://purl.uniprot.org/uniprot/A0A8B9TNC9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8839:LOC101799614 ^@ http://purl.uniprot.org/uniprot/R0JN79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcitonin family.|||Secreted http://togogenome.org/gene/8839:KCNG4 ^@ http://purl.uniprot.org/uniprot/A0A8B9T105 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:LOC101790354 ^@ http://purl.uniprot.org/uniprot/A0A8B9QZR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:RRH ^@ http://purl.uniprot.org/uniprot/R0JUG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/8839:RARB ^@ http://purl.uniprot.org/uniprot/A0A8B9TJH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/8839:MTMR9 ^@ http://purl.uniprot.org/uniprot/R0KZW3 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/8839:CDKN1B ^@ http://purl.uniprot.org/uniprot/Q6QWC3 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/8839:CDC42EP3 ^@ http://purl.uniprot.org/uniprot/A0A8B9SZR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/8839:PCYT1A ^@ http://purl.uniprot.org/uniprot/R0L7H3 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/8839:RPL19 ^@ http://purl.uniprot.org/uniprot/S4V6M7 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/8839:LOC101795677 ^@ http://purl.uniprot.org/uniprot/A0A8B9T4E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:AMH ^@ http://purl.uniprot.org/uniprot/Q0P6K6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Secreted http://togogenome.org/gene/8839:CAV1 ^@ http://purl.uniprot.org/uniprot/D7RF70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/8839:TSHZ2 ^@ http://purl.uniprot.org/uniprot/A0A8B9TMK3 ^@ Similarity ^@ Belongs to the teashirt C2H2-type zinc-finger protein family. http://togogenome.org/gene/8839:LOC101798456 ^@ http://purl.uniprot.org/uniprot/A0A8B9SQM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIP family.|||adherens junction|||centriolar satellite http://togogenome.org/gene/8839:TRAK2 ^@ http://purl.uniprot.org/uniprot/A0A8B9T134 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the milton family.|||Early endosome|||Mitochondrion http://togogenome.org/gene/8839:SLC5A3 ^@ http://purl.uniprot.org/uniprot/R0K5X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/8839:KLHL40 ^@ http://purl.uniprot.org/uniprot/R0JMM7 ^@ Similarity|||Subcellular Location Annotation ^@ A band|||Belongs to the KLHL40 family.|||I band http://togogenome.org/gene/8839:IFITM1 ^@ http://purl.uniprot.org/uniprot/A0A0C4K292 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/8839:LITAF ^@ http://purl.uniprot.org/uniprot/R0KR32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/8839:GYS2 ^@ http://purl.uniprot.org/uniprot/R0LET4 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 3 family.|||Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. http://togogenome.org/gene/8839:HDAC10 ^@ http://purl.uniprot.org/uniprot/A0A8B9TL37 ^@ Similarity ^@ Belongs to the histone deacetylase family. HD type 2 subfamily. http://togogenome.org/gene/8839:POMT1 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZF33 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/8839:IL17A ^@ http://purl.uniprot.org/uniprot/B0FYQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/8839:DYDC1 ^@ http://purl.uniprot.org/uniprot/A0A8B9TG86 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/8839:LOC101796851 ^@ http://purl.uniprot.org/uniprot/A0A8B9T9I6 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/8839:HOXB5 ^@ http://purl.uniprot.org/uniprot/A0A8B9SH00|||http://purl.uniprot.org/uniprot/R0L8J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/8839:MYOG ^@ http://purl.uniprot.org/uniprot/E5CYI9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8839:GPR146 ^@ http://purl.uniprot.org/uniprot/R0LKI7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8839:TRPM5 ^@ http://purl.uniprot.org/uniprot/A0A8B9R3K9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:EPHA7 ^@ http://purl.uniprot.org/uniprot/A0A8B9T9N8|||http://purl.uniprot.org/uniprot/R0M1N5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:SNX20 ^@ http://purl.uniprot.org/uniprot/R0LE57 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Membrane http://togogenome.org/gene/8839:FIGN ^@ http://purl.uniprot.org/uniprot/A0A8B9TW69 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/8839:LOC101793493 ^@ http://purl.uniprot.org/uniprot/Q8UWE2 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/8839:HDC ^@ http://purl.uniprot.org/uniprot/A0A8B9TV17 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/8839:SEC22A ^@ http://purl.uniprot.org/uniprot/R0LM61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/8839:IRF8 ^@ http://purl.uniprot.org/uniprot/Q0ZQ58 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8839:TNFSF15 ^@ http://purl.uniprot.org/uniprot/R0LCQ5 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/8839:CCNE2 ^@ http://purl.uniprot.org/uniprot/A0A8B9R8X6 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/8839:FUT10 ^@ http://purl.uniprot.org/uniprot/A0A8B9R0I9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Probable fucosyltransferase. http://togogenome.org/gene/8839:MC1R ^@ http://purl.uniprot.org/uniprot/G0XMW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. http://togogenome.org/gene/8839:SNTB1 ^@ http://purl.uniprot.org/uniprot/R0JVY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||Cell junction|||cytoskeleton http://togogenome.org/gene/8839:CAP2 ^@ http://purl.uniprot.org/uniprot/R0JNL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAP family.|||Cell membrane http://togogenome.org/gene/8839:GHR ^@ http://purl.uniprot.org/uniprot/C7DY43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Cell membrane|||The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. http://togogenome.org/gene/8839:NFE2L2 ^@ http://purl.uniprot.org/uniprot/A0A088MGY0 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/8839:CEPT1 ^@ http://purl.uniprot.org/uniprot/R0JFZ2 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/8839:ZNF622 ^@ http://purl.uniprot.org/uniprot/R0M156 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the REI1 family.|||Cytoplasm http://togogenome.org/gene/8839:AGPAT5 ^@ http://purl.uniprot.org/uniprot/R0M4A0 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/8839:LIMK2 ^@ http://purl.uniprot.org/uniprot/A0A8B9SMZ3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/8839:LOC101796828 ^@ http://purl.uniprot.org/uniprot/A0A8B9TRF4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:MIEF1 ^@ http://purl.uniprot.org/uniprot/R0JDV1 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/8839:TSPAN7 ^@ http://purl.uniprot.org/uniprot/A0A8B9T7K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8839:LOC101802880 ^@ http://purl.uniprot.org/uniprot/A0A8B9QVT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/8839:MINAR1 ^@ http://purl.uniprot.org/uniprot/R0KJZ6 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/8839:TUBB1 ^@ http://purl.uniprot.org/uniprot/A0A8B9SJR1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/8839:ARHGEF6 ^@ http://purl.uniprot.org/uniprot/R0JLG7 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/8839:ABHD2 ^@ http://purl.uniprot.org/uniprot/A0A8B9QUB7 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/8839:PSKH1 ^@ http://purl.uniprot.org/uniprot/R0JAC2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8839:RAP2A ^@ http://purl.uniprot.org/uniprot/R0L5P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/8839:ST6GAL1 ^@ http://purl.uniprot.org/uniprot/R0JBS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/8839:LCAT ^@ http://purl.uniprot.org/uniprot/Q9DDJ6 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/8839:TMEM19 ^@ http://purl.uniprot.org/uniprot/A0A8B9SGH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/8839:RFFL ^@ http://purl.uniprot.org/uniprot/R0LQ56 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/8839:LOC101799119 ^@ http://purl.uniprot.org/uniprot/R0LBP6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8839:TTR ^@ http://purl.uniprot.org/uniprot/Q2LDE6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transthyretin family.|||Homotetramer.|||Secreted|||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. http://togogenome.org/gene/8839:LOC101802994 ^@ http://purl.uniprot.org/uniprot/A0A8B9SY46 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/8839:XPO1 ^@ http://purl.uniprot.org/uniprot/A0A8B9T4L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm http://togogenome.org/gene/8839:HSD17B2 ^@ http://purl.uniprot.org/uniprot/R0LKH5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8839:PPARG ^@ http://purl.uniprot.org/uniprot/A5HNY5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Cytoplasm|||Heterodimer with other nuclear receptors.|||Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.|||Nucleus http://togogenome.org/gene/8839:ADGRD1 ^@ http://purl.uniprot.org/uniprot/R0JXN5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/8839:EXOC2 ^@ http://purl.uniprot.org/uniprot/A0A8B9T0V9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SEC5 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||Component of the exocyst complex. http://togogenome.org/gene/8839:LOC101794119 ^@ http://purl.uniprot.org/uniprot/A0A8B9QTP4 ^@ Similarity ^@ Belongs to the PTEN phosphatase protein family. http://togogenome.org/gene/8839:GJD2 ^@ http://purl.uniprot.org/uniprot/R0M753 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/8839:LOC110351185 ^@ http://purl.uniprot.org/uniprot/C7AFF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.|||Membrane http://togogenome.org/gene/8839:LOC101799748 ^@ http://purl.uniprot.org/uniprot/A0A8B9R0A2 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/8839:PRKCZ ^@ http://purl.uniprot.org/uniprot/A0A8B9TIB7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. http://togogenome.org/gene/8839:ATP6V0D2 ^@ http://purl.uniprot.org/uniprot/A0A8B9SNQ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/8839:SLC2A8 ^@ http://purl.uniprot.org/uniprot/A0A8B9R0J2 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/8839:C12H19orf12 ^@ http://purl.uniprot.org/uniprot/A0A8B9TGU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the C19orf12 family.|||Mitochondrion membrane http://togogenome.org/gene/8839:LOC101803572 ^@ http://purl.uniprot.org/uniprot/R0LHU9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8839:VANGL1 ^@ http://purl.uniprot.org/uniprot/A0A8B9SQ27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:TLR3 ^@ http://purl.uniprot.org/uniprot/A0A0A0V0T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/8839:UPP1 ^@ http://purl.uniprot.org/uniprot/A0A8B9R2P5 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. http://togogenome.org/gene/8839:THYN1 ^@ http://purl.uniprot.org/uniprot/A0A8B9T216 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. http://togogenome.org/gene/8839:JAKMIP1 ^@ http://purl.uniprot.org/uniprot/A0A8B9SP89 ^@ Similarity ^@ Belongs to the JAKMIP family. http://togogenome.org/gene/8839:CEBPG ^@ http://purl.uniprot.org/uniprot/R0JU53 ^@ Similarity ^@ Belongs to the bZIP family. C/EBP subfamily. http://togogenome.org/gene/8839:LOC101796665 ^@ http://purl.uniprot.org/uniprot/A0A8B9QYB5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:HENMT1 ^@ http://purl.uniprot.org/uniprot/R0JDI5 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. HEN1 family. http://togogenome.org/gene/8839:SPARC ^@ http://purl.uniprot.org/uniprot/A0A8B9SQ92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.|||Belongs to the SPARC family.|||Membrane|||basement membrane http://togogenome.org/gene/8839:FGF12 ^@ http://purl.uniprot.org/uniprot/A0A8B9T793 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8839:ACTA2 ^@ http://purl.uniprot.org/uniprot/A0A8B9TDD8 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/8839:NOG ^@ http://purl.uniprot.org/uniprot/R0LLV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the noggin family.|||Secreted http://togogenome.org/gene/8839:LOC101791654 ^@ http://purl.uniprot.org/uniprot/R0L5N3 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/8839:DHRS7 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZAW0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/8839:TLR5 ^@ http://purl.uniprot.org/uniprot/V9XUA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/8839:BCL2A1 ^@ http://purl.uniprot.org/uniprot/R0KRS9 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/8839:RSAD2 ^@ http://purl.uniprot.org/uniprot/A0A0B5JQU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RSAD2 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/8839:HECTD1 ^@ http://purl.uniprot.org/uniprot/A0A8B9TUS2 ^@ Function|||Similarity ^@ Belongs to the UPL family. K-HECT subfamily.|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. http://togogenome.org/gene/8839:NOP14 ^@ http://purl.uniprot.org/uniprot/R0LDU2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP14 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.|||nucleolus http://togogenome.org/gene/8839:SLC35A3 ^@ http://purl.uniprot.org/uniprot/A0A8B9TN86|||http://purl.uniprot.org/uniprot/A0A8B9TNE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/8839:TEKT3 ^@ http://purl.uniprot.org/uniprot/R0JIS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||flagellum http://togogenome.org/gene/8839:TENT5D ^@ http://purl.uniprot.org/uniprot/A0A8B9TRE7 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/8839:MDFIC ^@ http://purl.uniprot.org/uniprot/A0A8B9ZJS6 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/8839:DKK2 ^@ http://purl.uniprot.org/uniprot/R0LL40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/8839:ERRFI1 ^@ http://purl.uniprot.org/uniprot/R0JKY1 ^@ Subcellular Location Annotation ^@ Membrane|||Nucleus http://togogenome.org/gene/8839:STAMBPL1 ^@ http://purl.uniprot.org/uniprot/A0A8B9TBB8 ^@ Similarity ^@ Belongs to the peptidase M67C family. http://togogenome.org/gene/8839:PSPH ^@ http://purl.uniprot.org/uniprot/R0LQ88 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/8839:INHBA ^@ http://purl.uniprot.org/uniprot/R0LSN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/8839:FYN ^@ http://purl.uniprot.org/uniprot/R0JAE7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/8839:KIN ^@ http://purl.uniprot.org/uniprot/A0A8B9R1X8 ^@ Similarity ^@ Belongs to the KIN17 family. http://togogenome.org/gene/8839:SLC6A12 ^@ http://purl.uniprot.org/uniprot/R0LZH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/8839:ZDHHC22 ^@ http://purl.uniprot.org/uniprot/R0K5U8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/8839:NIT2 ^@ http://purl.uniprot.org/uniprot/A0A8B9R6T2 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/8839:NMUR2 ^@ http://purl.uniprot.org/uniprot/R0L5B8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/8839:MEOX2 ^@ http://purl.uniprot.org/uniprot/A0A8B9SHC2|||http://purl.uniprot.org/uniprot/R0K3I0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8839:CAVIN4 ^@ http://purl.uniprot.org/uniprot/A0A8B9SWW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/8839:DCN ^@ http://purl.uniprot.org/uniprot/R0LLK8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.|||May affect the rate of fibrils formation.|||extracellular matrix http://togogenome.org/gene/8839:PDP2 ^@ http://purl.uniprot.org/uniprot/A0A8B9SKN7 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/8839:LOC101796420 ^@ http://purl.uniprot.org/uniprot/R0LUG4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8839:SERPINH1 ^@ http://purl.uniprot.org/uniprot/R0JPJ8 ^@ Function|||Similarity ^@ Belongs to the serpin family.|||Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. http://togogenome.org/gene/8839:LOC101801574 ^@ http://purl.uniprot.org/uniprot/A0A8B9T4A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:HOXA6 ^@ http://purl.uniprot.org/uniprot/A0A8B9QNS9|||http://purl.uniprot.org/uniprot/R0LGR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/8839:LOC101798290 ^@ http://purl.uniprot.org/uniprot/R0J7H7 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/8839:RAB19 ^@ http://purl.uniprot.org/uniprot/A0A8B9TYN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane http://togogenome.org/gene/8839:IFITM10 ^@ http://purl.uniprot.org/uniprot/A0A0C4K5J3 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/8839:LOC101790670 ^@ http://purl.uniprot.org/uniprot/Q04791 ^@ Function|||Similarity|||Tissue Specificity ^@ Belongs to the type-B carboxylesterase/lipase family.|||Fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by hydrolysis of the thio ester by a thioesterase. This thioesterase may be associated with peroxisome proliferation and may play a role in the production of 3-hydroxy fatty acid diester pheromones.|||Highest levels in uropygial gland, much lower in liver and kidney. http://togogenome.org/gene/8839:TSHB ^@ http://purl.uniprot.org/uniprot/Q2Q1W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/8839:FGFBP2 ^@ http://purl.uniprot.org/uniprot/R0LBY3 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/8839:GPX7 ^@ http://purl.uniprot.org/uniprot/R0JF99 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/8839:KPNA2 ^@ http://purl.uniprot.org/uniprot/R0M1W9 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/8839:VTI1A ^@ http://purl.uniprot.org/uniprot/A0A8B9SSE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/8839:CD8A ^@ http://purl.uniprot.org/uniprot/J7FMN6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/8839:ADPRHL1 ^@ http://purl.uniprot.org/uniprot/A0A8B9SIJ3 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/8839:LOC101790267 ^@ http://purl.uniprot.org/uniprot/I6V7Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/8839:LOC101790527 ^@ http://purl.uniprot.org/uniprot/R0JUF1 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/8839:SPON2 ^@ http://purl.uniprot.org/uniprot/R0K2H0 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/8839:AMER3 ^@ http://purl.uniprot.org/uniprot/R0LXF8 ^@ Similarity ^@ Belongs to the Amer family. http://togogenome.org/gene/8839:KEG62_p12 ^@ http://purl.uniprot.org/uniprot/Q7J4X8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 2 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/8839:LOC101792508 ^@ http://purl.uniprot.org/uniprot/A0A8B9TUS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:VLDLR ^@ http://purl.uniprot.org/uniprot/G1D8U0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8839:GPR137B ^@ http://purl.uniprot.org/uniprot/A0A8B9TV76 ^@ Subcellular Location Annotation ^@ Lysosome membrane|||Membrane http://togogenome.org/gene/8839:CHRM5 ^@ http://purl.uniprot.org/uniprot/R0M314 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/8839:STK11 ^@ http://purl.uniprot.org/uniprot/A0A8B9SWH7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily. http://togogenome.org/gene/8839:CXXC5 ^@ http://purl.uniprot.org/uniprot/A0A8B9TAK1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8839:LYRM9 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZH21 ^@ Similarity ^@ Belongs to the complex I LYR family. LYRM9 subfamily. http://togogenome.org/gene/8839:PLCB2 ^@ http://purl.uniprot.org/uniprot/A0A8B9QRH3|||http://purl.uniprot.org/uniprot/A0A8B9SGS7 ^@ Cofactor|||Function ^@ Binds 1 Ca(2+) ion per subunit.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/8839:HOXA5 ^@ http://purl.uniprot.org/uniprot/A0A8B9QQG2|||http://purl.uniprot.org/uniprot/R0L1L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/8839:PAX7 ^@ http://purl.uniprot.org/uniprot/I7FSJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/8839:GRIN1 ^@ http://purl.uniprot.org/uniprot/Q91979 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/8839:FGF23 ^@ http://purl.uniprot.org/uniprot/A0A8B9TA87 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/8839:PDLIM3 ^@ http://purl.uniprot.org/uniprot/A0A8B9SRF7|||http://purl.uniprot.org/uniprot/A0A8B9ZCD2 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/8839:LOC101799623 ^@ http://purl.uniprot.org/uniprot/A0A8B9TWX1 ^@ Subcellular Location Annotation ^@ Cell membrane|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/8839:CPZ ^@ http://purl.uniprot.org/uniprot/A0A8B9ZFR8 ^@ Caution|||Similarity ^@ Belongs to the peptidase M14 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8839:LOC101792573 ^@ http://purl.uniprot.org/uniprot/A0A8B9QZP4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/8839:AQP1 ^@ http://purl.uniprot.org/uniprot/R0K8H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/8839:AKIRIN2 ^@ http://purl.uniprot.org/uniprot/G0TA26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/8839:ETFRF1 ^@ http://purl.uniprot.org/uniprot/R0JN64 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/8839:MYF5 ^@ http://purl.uniprot.org/uniprot/D6BU30 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/8839:GABRA1 ^@ http://purl.uniprot.org/uniprot/R0LMX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/8839:SLC16A9 ^@ http://purl.uniprot.org/uniprot/R0LF40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:BET1L ^@ http://purl.uniprot.org/uniprot/A0A8B9QUP7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:IFNG ^@ http://purl.uniprot.org/uniprot/Q0MRR0|||http://purl.uniprot.org/uniprot/Q9YGB9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II (or gamma) interferon family.|||Homodimer.|||Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.|||Secreted http://togogenome.org/gene/8839:BTBD10 ^@ http://purl.uniprot.org/uniprot/A0A8B9T0I5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/8839:SUCNR1 ^@ http://purl.uniprot.org/uniprot/A0A8B9TJ60 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8839:C2H7orf25 ^@ http://purl.uniprot.org/uniprot/A0A8B9R366 ^@ Similarity ^@ Belongs to the UPF0415 family. http://togogenome.org/gene/8839:LOC101802682 ^@ http://purl.uniprot.org/uniprot/R0JP17 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8839:KEG62_p06 ^@ http://purl.uniprot.org/uniprot/A6ZJ06 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 3 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.|||Mitochondrion membrane http://togogenome.org/gene/8839:LPAR3 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZCP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/8839:LOC101798228 ^@ http://purl.uniprot.org/uniprot/R0LSB2 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/8839:LOC101795719 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZE04 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARL2BP family.|||Cytoplasm|||Mitochondrion intermembrane space|||Nucleus|||Plays a role as an effector of the ADP-ribosylation factor-like protein 2, ARL2.|||centrosome|||cilium basal body http://togogenome.org/gene/8839:CDK3 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZGH0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/8839:LOC101803044 ^@ http://purl.uniprot.org/uniprot/A0A8B9Z9Z3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/8839:P2RY8 ^@ http://purl.uniprot.org/uniprot/A0A8B9QQ50 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/8839:SLC16A1 ^@ http://purl.uniprot.org/uniprot/R0K776 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/8839:GCG ^@ http://purl.uniprot.org/uniprot/A0A8B9TVD6 ^@ Similarity ^@ Belongs to the glucagon family. http://togogenome.org/gene/8839:PLA2R1 ^@ http://purl.uniprot.org/uniprot/A0A0D3RVN4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/8839:TSPAN4 ^@ http://purl.uniprot.org/uniprot/A0A8B9TSJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/8839:GDPD1 ^@ http://purl.uniprot.org/uniprot/A0A8B9TRE4 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/8839:TPRA1 ^@ http://purl.uniprot.org/uniprot/A0A8B9T1X9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0359 family.|||Membrane http://togogenome.org/gene/8839:FABP1 ^@ http://purl.uniprot.org/uniprot/A0A8B9SJJ1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.|||Cytoplasm|||Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. http://togogenome.org/gene/8839:LOC101795406 ^@ http://purl.uniprot.org/uniprot/A0A076FVB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lambda interferon family.|||Secreted http://togogenome.org/gene/8839:PRKACB ^@ http://purl.uniprot.org/uniprot/R0JPM8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/8839:ATP1A1 ^@ http://purl.uniprot.org/uniprot/Q7ZYV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane http://togogenome.org/gene/8839:NDST4 ^@ http://purl.uniprot.org/uniprot/R0L8A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/8839:TADA1 ^@ http://purl.uniprot.org/uniprot/A0A8B9ZIZ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TADA1 family.|||Nucleus|||Probably involved in transcriptional regulation. http://togogenome.org/gene/8839:LOC101790996 ^@ http://purl.uniprot.org/uniprot/R0JRB7 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/8839:PTHLH ^@ http://purl.uniprot.org/uniprot/A0A8B9SKY8|||http://purl.uniprot.org/uniprot/R0KD54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parathyroid hormone family.|||Secreted http://togogenome.org/gene/8839:ASPA ^@ http://purl.uniprot.org/uniprot/R0JND7 ^@ Cofactor|||Similarity ^@ Belongs to the AspA/AstE family. Aspartoacylase subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/8839:LOC101804741 ^@ http://purl.uniprot.org/uniprot/A0A8B9TTK1 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/8839:TXNL4B ^@ http://purl.uniprot.org/uniprot/R0M356 ^@ Similarity ^@ Belongs to the DIM1 family. http://togogenome.org/gene/8839:PBRM1 ^@ http://purl.uniprot.org/uniprot/A0A8B9TJ89|||http://purl.uniprot.org/uniprot/R0JIY6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/8839:RPL17 ^@ http://purl.uniprot.org/uniprot/A0A8B9TX19 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/8839:WNT7B ^@ http://purl.uniprot.org/uniprot/R0M2F0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix