http://togogenome.org/gene/9135:MRPS17 ^@ http://purl.uniprot.org/uniprot/A0A8C9MW20 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/9135:C1H12orf57 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0456 family.|||Cytoplasm http://togogenome.org/gene/9135:LOC103820122 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKJ2 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/9135:HSF4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9135:ADRA1D ^@ http://purl.uniprot.org/uniprot/A0A8C9N423 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.|||Membrane|||This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. http://togogenome.org/gene/9135:STAT4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJ66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:TRNT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NF60 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/9135:LOC103823737 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRL1 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9135:LOC103819811 ^@ http://purl.uniprot.org/uniprot/A0A8C9NHN2 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9135:PPM1L ^@ http://purl.uniprot.org/uniprot/A0A8C9N5R7 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9135:MTMR4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9135:RAB32 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9135:KCNMB4 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1B1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:LOC103819081 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFX0 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9135:DGKD ^@ http://purl.uniprot.org/uniprot/A0A8C9MI75 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9135:STAG2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UI58 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/9135:ZFYVE9 ^@ http://purl.uniprot.org/uniprot/A0A8C9MSG0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Early endosome membrane http://togogenome.org/gene/9135:CHAF1B ^@ http://purl.uniprot.org/uniprot/A0A8C9N8Q3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:FAM83F ^@ http://purl.uniprot.org/uniprot/A0A8C9MQF4 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9135:AMZ1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1H4 ^@ Function|||Similarity ^@ Belongs to the peptidase M54 family.|||Probable zinc metalloprotease. http://togogenome.org/gene/9135:SLC25A24 ^@ http://purl.uniprot.org/uniprot/A0A8C9NE00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9135:GINS2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MU29 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS2/PSF2 family.|||Chromosome|||Component of the GINS complex.|||Nucleus http://togogenome.org/gene/9135:OSBPL5 ^@ http://purl.uniprot.org/uniprot/A0A8C9MN98 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9135:RIDA ^@ http://purl.uniprot.org/uniprot/A0A8C9MKW2 ^@ Function|||Similarity ^@ Belongs to the RutC family.|||Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. http://togogenome.org/gene/9135:TBCE ^@ http://purl.uniprot.org/uniprot/A0A8C9U7P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCE family.|||Cytoplasm http://togogenome.org/gene/9135:BCHE ^@ http://purl.uniprot.org/uniprot/A0A8C9UD72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Secreted http://togogenome.org/gene/9135:ATP2A2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UDK9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9135:GGA2 ^@ http://purl.uniprot.org/uniprot/A0A8C9U5L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9135:LOC103817747 ^@ http://purl.uniprot.org/uniprot/A0A8C9UFC5 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9135:PSAP ^@ http://purl.uniprot.org/uniprot/A0A8C9UID4 ^@ Function|||Subcellular Location Annotation ^@ Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.|||Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.|||Secreted http://togogenome.org/gene/9135:RAB9B ^@ http://purl.uniprot.org/uniprot/A0A8C9NVZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||phagosome membrane http://togogenome.org/gene/9135:LAMA4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMJ8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9135:STXBP5L ^@ http://purl.uniprot.org/uniprot/A0A8C9N8R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9135:PEX5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPF1 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/9135:NDUFA8 ^@ http://purl.uniprot.org/uniprot/A0A8C9L1C8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA8 subunit family.|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9135:KIN ^@ http://purl.uniprot.org/uniprot/A0A8C9N463 ^@ Similarity ^@ Belongs to the KIN17 family. http://togogenome.org/gene/9135:HOGA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NTI3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the final step in the metabolic pathway of hydroxyproline.|||Homotetramer. http://togogenome.org/gene/9135:C4H4orf48 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPF7 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9135:BMP5 ^@ http://purl.uniprot.org/uniprot/A0A8C9N9W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/9135:HAAO ^@ http://purl.uniprot.org/uniprot/A0A8C9N5K4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 3-HAO family.|||Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/9135:ACOX2 ^@ http://purl.uniprot.org/uniprot/A0A8C9U9M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/9135:HSBP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVG0 ^@ Similarity ^@ Belongs to the HSBP1 family. http://togogenome.org/gene/9135:ZDHHC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MSG6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9135:LOC103820555 ^@ http://purl.uniprot.org/uniprot/A0A8C9NA76 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.|||Secreted http://togogenome.org/gene/9135:OPRL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPL5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle|||G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.|||Membrane|||Vesicle http://togogenome.org/gene/9135:NOP58 ^@ http://purl.uniprot.org/uniprot/A0A8C9MG34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus http://togogenome.org/gene/9135:IL18 ^@ http://purl.uniprot.org/uniprot/A0A8C9MWM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Cytoplasm|||Secreted http://togogenome.org/gene/9135:WDR24 ^@ http://purl.uniprot.org/uniprot/A0A8C9NG50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR24 family.|||Lysosome membrane http://togogenome.org/gene/9135:MAT1A ^@ http://purl.uniprot.org/uniprot/A0A8C9MHW9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/9135:MINDY2 ^@ http://purl.uniprot.org/uniprot/A0A8C9KNX8 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM63 subfamily.|||Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. http://togogenome.org/gene/9135:RAD51 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAX3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Nucleus|||Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair. http://togogenome.org/gene/9135:CPLX4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9135:MAP3K7 ^@ http://purl.uniprot.org/uniprot/A0A8C9KYJ9|||http://purl.uniprot.org/uniprot/A0A8C9L3E4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/9135:TPD52 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFU5 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9135:HSPA4 ^@ http://purl.uniprot.org/uniprot/A0A8C9KXG7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm|||Interacts with TJP1/ZO-1. http://togogenome.org/gene/9135:RFFL ^@ http://purl.uniprot.org/uniprot/A0A8C9MTH2|||http://purl.uniprot.org/uniprot/A0A8C9MV39 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9135:LLPH ^@ http://purl.uniprot.org/uniprot/A0A8C9MGY2 ^@ Similarity ^@ Belongs to the learning-associated protein family. http://togogenome.org/gene/9135:LPAR6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NIC7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:TMOD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NA02 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9135:AP3B2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NS22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes large subunit family.|||Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9135:WDR48 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR48 family.|||Late endosome http://togogenome.org/gene/9135:ABHD3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N9M7 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/9135:LMBR1L ^@ http://purl.uniprot.org/uniprot/A0A8C9NM09 ^@ Similarity ^@ Belongs to the LIMR family. http://togogenome.org/gene/9135:B9D1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2Y7 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9135:KIFC3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUB1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9135:GATA3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N783 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:ABAT ^@ http://purl.uniprot.org/uniprot/A0A8C9NB72 ^@ Similarity|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9135:FAM161B ^@ http://purl.uniprot.org/uniprot/A0A8C9N9S3 ^@ Similarity ^@ Belongs to the FAM161 family. http://togogenome.org/gene/9135:ASRGL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N0I1 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/9135:SASS6 ^@ http://purl.uniprot.org/uniprot/A0A8C9UFK1 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/9135:AZIN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9U9G7 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9135:SPSB4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Cytoplasm http://togogenome.org/gene/9135:LOC103823377 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFP7 ^@ Function|||Similarity ^@ Belongs to the janus family.|||Exhibits phosphohistidine phosphatase activity. http://togogenome.org/gene/9135:MTIF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGA9 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/9135:TXLNA ^@ http://purl.uniprot.org/uniprot/A0A8C9MP77 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9135:TSSC4 ^@ http://purl.uniprot.org/uniprot/A0A8C9U716 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TSSC4 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:TACR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NP46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:HTR2A ^@ http://purl.uniprot.org/uniprot/A0A8C9NII0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin).|||Membrane|||Presynapse|||Synapse|||Vesicle|||axon|||caveola|||dendrite http://togogenome.org/gene/9135:RNASET2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase T2 family.|||Lysosome lumen http://togogenome.org/gene/9135:NPBWR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NID9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:ATP6V1H ^@ http://purl.uniprot.org/uniprot/A0A8C9UFU0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9135:LOC103821893 ^@ http://purl.uniprot.org/uniprot/A0A8C9U6Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/9135:EIF6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-6 family.|||Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.|||Cytoplasm|||Monomer. Associates with the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/9135:UTP18 ^@ http://purl.uniprot.org/uniprot/A0A8C9NP45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat UTP18 family.|||nucleolus http://togogenome.org/gene/9135:MFGE8 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRS4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:CENPI ^@ http://purl.uniprot.org/uniprot/A0A8C9NT41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-I/CTF3 family.|||Nucleus|||centromere http://togogenome.org/gene/9135:AQP3 ^@ http://purl.uniprot.org/uniprot/A0A8C9UHV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:CEMIP ^@ http://purl.uniprot.org/uniprot/A0A8C9U9Z9 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/9135:ANKZF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NL10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANKZF1/VMS1 family.|||Cytoplasm http://togogenome.org/gene/9135:ZDHHC6 ^@ http://purl.uniprot.org/uniprot/A0A8C9UHC8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9135:GLYR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MH37|||http://purl.uniprot.org/uniprot/A0A8C9MH91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HIBADH-related family. NP60 subfamily.|||Belongs to the rogdi family.|||Chromosome|||Presynapse|||Vesicle|||synaptic vesicle http://togogenome.org/gene/9135:LOC103822817 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9135:SLC51A ^@ http://purl.uniprot.org/uniprot/A0A8C9NIZ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:SCRN3 ^@ http://purl.uniprot.org/uniprot/A0A8C9UI32 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/9135:GSTZ1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UDE7 ^@ Similarity ^@ Belongs to the GST superfamily. Zeta family. http://togogenome.org/gene/9135:CXXC5 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1I1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9135:UIMC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJ33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAP80 family.|||Nucleus http://togogenome.org/gene/9135:BNIP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPG8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:LOC103818038 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9135:STRADB ^@ http://purl.uniprot.org/uniprot/A0A8C9MGJ1 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. http://togogenome.org/gene/9135:UBA3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYU7 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.|||Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. http://togogenome.org/gene/9135:SUDS3 ^@ http://purl.uniprot.org/uniprot/A0A8C9U7S4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:LOC103823724 ^@ http://purl.uniprot.org/uniprot/A0A8C9NT74 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9135:CORIN ^@ http://purl.uniprot.org/uniprot/A0A8C9MYK8 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:BCL2L13 ^@ http://purl.uniprot.org/uniprot/A0A8C9MS21 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9135:MAPKAPK3 ^@ http://purl.uniprot.org/uniprot/A0A8C9KWC2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:PPIL4 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1I4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9135:LECT2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8F3 ^@ Similarity ^@ Belongs to the LECT2/MIM-1 family. http://togogenome.org/gene/9135:GPR39 ^@ http://purl.uniprot.org/uniprot/A0A8C9N990 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:EEF1AKMT2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.|||Cytoplasm|||Nucleus|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'. http://togogenome.org/gene/9135:LOC103812325 ^@ http://purl.uniprot.org/uniprot/A0A8C9NSD7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/9135:PAMR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJW0|||http://purl.uniprot.org/uniprot/A0A8C9MK27 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:ANAPC4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMX1 ^@ Function|||Similarity ^@ Belongs to the APC4 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/9135:TEK ^@ http://purl.uniprot.org/uniprot/A0A8C9N825 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:GRK7 ^@ http://purl.uniprot.org/uniprot/A0A8C9ME69 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9135:LOC103823540 ^@ http://purl.uniprot.org/uniprot/A0A8C9N140 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9135:SLC52A3 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGF3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/9135:TXLNB ^@ http://purl.uniprot.org/uniprot/A0A8C9MI48 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9135:PSPC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PSPC family.|||Cytoplasm|||Nucleus matrix|||Nucleus speckle|||nucleolus http://togogenome.org/gene/9135:PSMF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGF7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the proteasome inhibitor PI31 family.|||Cytoplasm|||Endoplasmic reticulum|||Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28. http://togogenome.org/gene/9135:SLC34A2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MP72 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:LOC103819677 ^@ http://purl.uniprot.org/uniprot/A0A8C9MY64 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/9135:REV1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NTZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-Y family.|||Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.|||Nucleus http://togogenome.org/gene/9135:ACTR8 ^@ http://purl.uniprot.org/uniprot/A0A8C9U2X7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin family. ARP8 subfamily.|||Chromosome|||Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.|||Nucleus|||Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.|||Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. http://togogenome.org/gene/9135:ACAA2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NUB3 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9135:PHYHIPL ^@ http://purl.uniprot.org/uniprot/A0A8C9MJU9 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/9135:CHRNA9 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9135:SCAMP4 ^@ http://purl.uniprot.org/uniprot/A0A8C9KUM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9135:PWP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UEB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PWP2 family.|||nucleolus http://togogenome.org/gene/9135:RHBDD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KSP7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:TRAF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N9M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9135:CDC37L1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KSH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/9135:MMP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MPG3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||extracellular matrix http://togogenome.org/gene/9135:GALR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MWL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9135:PRICKLE1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJF4 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/9135:CTLA4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MF82 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.|||Membrane http://togogenome.org/gene/9135:ST7 ^@ http://purl.uniprot.org/uniprot/A0A8C9N5E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/9135:RBP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N4S3 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9135:AGTR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NNM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. http://togogenome.org/gene/9135:TOP2B ^@ http://purl.uniprot.org/uniprot/A0A8C9NNT4|||http://purl.uniprot.org/uniprot/A0A8C9NPY4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase family.|||Homodimer.|||Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9135:SMARCAL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NHA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.|||Nucleus http://togogenome.org/gene/9135:FGF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9L6A6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Cytoplasm|||Nucleus|||Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.|||Secreted|||cell cortex|||cytosol http://togogenome.org/gene/9135:EVX1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPQ8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:SMAD3 ^@ http://purl.uniprot.org/uniprot/A0A8C9UE68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:CDCA7L ^@ http://purl.uniprot.org/uniprot/A0A8C9NN99 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9135:HLF ^@ http://purl.uniprot.org/uniprot/A0A8C9NNC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/9135:EXOC2 ^@ http://purl.uniprot.org/uniprot/A0A8C9L4H9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SEC5 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||Component of the exocyst complex. http://togogenome.org/gene/9135:HACD4 ^@ http://purl.uniprot.org/uniprot/A0A8C9KXH9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:CDCA8 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the borealin family.|||centromere http://togogenome.org/gene/9135:HGD ^@ http://purl.uniprot.org/uniprot/A0A8C9N2Z2|||http://purl.uniprot.org/uniprot/A0A8C9N718 ^@ Similarity ^@ Belongs to the homogentisate dioxygenase family. http://togogenome.org/gene/9135:ANPEP ^@ http://purl.uniprot.org/uniprot/A0A8C9NL29 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9135:CASQ2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N6M5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/9135:PGK1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NU98 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/9135:ROPN1L ^@ http://purl.uniprot.org/uniprot/A0A8C9MMV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ropporin family.|||flagellum http://togogenome.org/gene/9135:CMTM6 ^@ http://purl.uniprot.org/uniprot/A0A8C9MDS6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:LIPH ^@ http://purl.uniprot.org/uniprot/A0A8C9MRH5|||http://purl.uniprot.org/uniprot/A0A8C9MRU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9135:JUN ^@ http://purl.uniprot.org/uniprot/P54864 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family. Jun subfamily.|||Interacts with FOS to form a dimer.|||Nucleus|||Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter. http://togogenome.org/gene/9135:ACAD11 ^@ http://purl.uniprot.org/uniprot/A0A8C9L4Z0 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9135:MCM8 ^@ http://purl.uniprot.org/uniprot/A0A8C9KQ56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/9135:TMEM178B ^@ http://purl.uniprot.org/uniprot/A0A8C9N4H7 ^@ Similarity ^@ Belongs to the TMEM178 family. http://togogenome.org/gene/9135:CER1 ^@ http://purl.uniprot.org/uniprot/A0A8C9L411 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9135:HEXD ^@ http://purl.uniprot.org/uniprot/A0A8C9U471 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 20 family. http://togogenome.org/gene/9135:LOC108961555 ^@ http://purl.uniprot.org/uniprot/A0A8C9UBC1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9135:APLP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NWM3|||http://purl.uniprot.org/uniprot/A0A8C9NYB0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:LOC103826034 ^@ http://purl.uniprot.org/uniprot/A0A8C9NK54 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. http://togogenome.org/gene/9135:EHF ^@ http://purl.uniprot.org/uniprot/A0A8C9MKA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9135:CNR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MU94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:GPR55 ^@ http://purl.uniprot.org/uniprot/A0A8C9NW76 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:PPP4R3A ^@ http://purl.uniprot.org/uniprot/A0A8C9N0H8 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/9135:UGDH ^@ http://purl.uniprot.org/uniprot/A0A8C9U8M7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.|||Homohexamer.|||Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. http://togogenome.org/gene/9135:STK17A ^@ http://purl.uniprot.org/uniprot/A0A8C9NSA2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:PRTFDC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UDU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/9135:PI4K2B ^@ http://purl.uniprot.org/uniprot/A0A8C9MMS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.|||Membrane http://togogenome.org/gene/9135:OGN ^@ http://purl.uniprot.org/uniprot/A0A8C9NEA5 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/9135:SEPTIN2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cleavage furrow|||Midbody|||cilium membrane|||spindle http://togogenome.org/gene/9135:OPRK1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UFB0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.|||Interacts with NHERF1. Interacts with GABARAPL1.|||Membrane http://togogenome.org/gene/9135:DIABLO ^@ http://purl.uniprot.org/uniprot/A0A8C9N5K2 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9135:GJB1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NV40 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9135:NMD3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N404 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.|||Belongs to the NMD3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:LOC103819249 ^@ http://purl.uniprot.org/uniprot/A0A8C9NL09 ^@ Similarity ^@ Belongs to the PRORSD1 family. http://togogenome.org/gene/9135:CKAP2L ^@ http://purl.uniprot.org/uniprot/A0A8C9NSP0 ^@ Similarity ^@ Belongs to the CKAP2 family. http://togogenome.org/gene/9135:MBTD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NP55 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:RSL24D1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KV87 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/9135:LOC108962077 ^@ http://purl.uniprot.org/uniprot/A0A8C9ML15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the C19orf12 family.|||Mitochondrion membrane http://togogenome.org/gene/9135:SNX1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Endosome membrane|||Membrane|||lamellipodium|||trans-Golgi network membrane http://togogenome.org/gene/9135:SLC7A2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N462 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:NDST2 ^@ http://purl.uniprot.org/uniprot/A0A8C9KUV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9135:ENTPD5 ^@ http://purl.uniprot.org/uniprot/A0A8C9UE31 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9135:SMN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMN family.|||Cajal body|||Perikaryon|||Z line|||gem|||neuron projection http://togogenome.org/gene/9135:SLC14A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NUS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urea transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:CNIH1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9135:LOC103820504 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHE4 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9135:PROK2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/9135:GINS4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NXQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS4/SLD5 family.|||Chromosome|||Nucleus|||Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/9135:LOC103822739 ^@ http://purl.uniprot.org/uniprot/A0A8C9NX38 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:MARF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UEV7 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9135:GET1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NBB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WRB/GET1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:HAO2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8C0 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/9135:KCTD20 ^@ http://purl.uniprot.org/uniprot/A0A8C9NH58 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9135:GHRH ^@ http://purl.uniprot.org/uniprot/A0A8C9NF72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/9135:DDX5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NLT7 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. http://togogenome.org/gene/9135:LOC103821679 ^@ http://purl.uniprot.org/uniprot/A0A8C9UEA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:LOC103818637 ^@ http://purl.uniprot.org/uniprot/A0A8C9NH78|||http://purl.uniprot.org/uniprot/A0A8C9NHN4 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9135:C7H2orf76 ^@ http://purl.uniprot.org/uniprot/A0A8C9N806 ^@ Similarity ^@ Belongs to the UPF0538 family. http://togogenome.org/gene/9135:ALPL ^@ http://purl.uniprot.org/uniprot/A0A8C9MKE0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alkaline phosphatase family.|||Binds 1 Mg(2+) ion.|||Binds 2 Zn(2+) ions.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/9135:VPS4B ^@ http://purl.uniprot.org/uniprot/A0A8C9MG21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9135:FOXN2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UFA1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:RPLP0 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLW2 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL10 family.|||Ribosomal protein P0 is the functional equivalent of E.coli protein L10. http://togogenome.org/gene/9135:SF3B3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRR0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:COG6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NH63 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COG6 family.|||Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.|||Golgi apparatus membrane|||Membrane|||Required for normal Golgi function. http://togogenome.org/gene/9135:ESR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Binds DNA as a homodimer.|||Nucleus|||The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. http://togogenome.org/gene/9135:USP20 ^@ http://purl.uniprot.org/uniprot/A0A8C9MNG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family. USP20/USP33 subfamily.|||centrosome|||perinuclear region http://togogenome.org/gene/9135:RFX3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MI86 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:LOC103827286 ^@ http://purl.uniprot.org/uniprot/A0A8C9U7B4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9135:VIPR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N105 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:NTNG2 ^@ http://purl.uniprot.org/uniprot/A0A8C9U5T9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:SLC66A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KXV0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:DEGS1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:ADORA2B ^@ http://purl.uniprot.org/uniprot/A0A8C9N558 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/9135:SEMA5B ^@ http://purl.uniprot.org/uniprot/A0A8C9NCS5|||http://purl.uniprot.org/uniprot/A0A8C9NEX4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:LOC103814228 ^@ http://purl.uniprot.org/uniprot/A0A8C9U5W4 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9135:DOCK9 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMF1 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9135:MOV10 ^@ http://purl.uniprot.org/uniprot/A0A8C9NNP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.|||P-body http://togogenome.org/gene/9135:CEP76 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZQ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP76 family.|||Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.|||centriole http://togogenome.org/gene/9135:CSNK1A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KWX4|||http://purl.uniprot.org/uniprot/A0A8C9L633 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:LIG4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NS17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/9135:SEMA4D ^@ http://purl.uniprot.org/uniprot/A0A8C9NLU2 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:TINAG ^@ http://purl.uniprot.org/uniprot/A0A8C9NCC2 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9135:NOG ^@ http://purl.uniprot.org/uniprot/A0A8C9NNW1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the noggin family.|||Homodimer.|||Secreted http://togogenome.org/gene/9135:HMOX2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NG80 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/9135:TWSG1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N458 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the twisted gastrulation protein family.|||Secreted http://togogenome.org/gene/9135:GALNT7 ^@ http://purl.uniprot.org/uniprot/A0A8C9N6T0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9135:DPH3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMC3 ^@ Similarity ^@ Belongs to the DPH3 family. http://togogenome.org/gene/9135:TNFAIP6 ^@ http://purl.uniprot.org/uniprot/A0A8C9N046 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:PNPLA4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NIG5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:GMPPB ^@ http://purl.uniprot.org/uniprot/A0A8C9NK98 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/9135:BCL2L1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NN65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Membrane|||Mitochondrion matrix|||Nucleus membrane|||centrosome|||cytosol|||synaptic vesicle membrane http://togogenome.org/gene/9135:TUSC3 ^@ http://purl.uniprot.org/uniprot/A0A8C9UCQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:TIMM10 ^@ http://purl.uniprot.org/uniprot/A0A8C9N6X1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9135:LRRFIP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NX34|||http://purl.uniprot.org/uniprot/A0A8C9NXE6 ^@ Similarity ^@ Belongs to the LRRFIP family. http://togogenome.org/gene/9135:PDE6H ^@ http://purl.uniprot.org/uniprot/A0A8C9MTG5 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/9135:KATNAL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UBK9 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.|||Cytoplasm|||Interacts with KATNB1 and KATNBL1.|||Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9135:MIEF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQ17 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9135:LOC103815539 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2A1|||http://purl.uniprot.org/uniprot/A0A8C9N2R1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9135:LOC103826639 ^@ http://purl.uniprot.org/uniprot/A0A8C9NK90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/9135:TUBB6 ^@ http://purl.uniprot.org/uniprot/A0A8C9N111 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9135:LOC103824645 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGA3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Golgi apparatus http://togogenome.org/gene/9135:CENPU ^@ http://purl.uniprot.org/uniprot/A0A8C9N701 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-U/AME1 family.|||Nucleus http://togogenome.org/gene/9135:SLC17A6 ^@ http://purl.uniprot.org/uniprot/A0A8C9N288 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:B3GNT5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NL43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9135:POFUT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKP0 ^@ Similarity ^@ Belongs to the glycosyltransferase 65 family. http://togogenome.org/gene/9135:DKK2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9135:CLTCL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MM72 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin heavy chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||Membrane|||coated pit http://togogenome.org/gene/9135:RGS7BP ^@ http://purl.uniprot.org/uniprot/A0A8C9N9X9 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/9135:NSF ^@ http://purl.uniprot.org/uniprot/A0A8C9N0L9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. http://togogenome.org/gene/9135:TMEM59 ^@ http://purl.uniprot.org/uniprot/A0A8C9U9N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM59 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9135:BID ^@ http://purl.uniprot.org/uniprot/A0A8C9MRC5 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2.|||Induces caspases and apoptosis. Counters the protective effect of BCL2.|||Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9135:NPL ^@ http://purl.uniprot.org/uniprot/A0A8C9N927 ^@ Similarity|||Subunit ^@ Belongs to the DapA family.|||Homotetramer. http://togogenome.org/gene/9135:MPI ^@ http://purl.uniprot.org/uniprot/A0A8C9NEC0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/9135:TSPAN33 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9135:ARPC1B ^@ http://purl.uniprot.org/uniprot/A0A8C9N2G8 ^@ Function|||Similarity ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. http://togogenome.org/gene/9135:SLC17A8 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUH3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:EMC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KWI6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC1 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:PAH ^@ http://purl.uniprot.org/uniprot/A0A8C9UE43 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/9135:MAB21L2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGZ5 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9135:FABP3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPY3 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9135:SLC29A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NLH3 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9135:QNG1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MN88 ^@ Function|||Similarity ^@ Belongs to the QNG1 protein family.|||Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly. http://togogenome.org/gene/9135:SAG ^@ http://purl.uniprot.org/uniprot/A0A8C9MIF4 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9135:BORCS5 ^@ http://purl.uniprot.org/uniprot/A0A8C9N962 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS5 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9135:UNC119 ^@ http://purl.uniprot.org/uniprot/A0A8C9MXB8 ^@ Similarity ^@ Belongs to the PDE6D/unc-119 family. http://togogenome.org/gene/9135:EPS8 ^@ http://purl.uniprot.org/uniprot/A0A8C9MV61 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/9135:TCEANC2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTY4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:LOC103817059 ^@ http://purl.uniprot.org/uniprot/A0A8C9UAI5 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:VWA2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UHN6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:TNFRSF6B ^@ http://purl.uniprot.org/uniprot/A0A8C9NP97 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:TMEM38A ^@ http://purl.uniprot.org/uniprot/A0A8C9U756 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/9135:RFC4 ^@ http://purl.uniprot.org/uniprot/A0A8C9UFZ0 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/9135:XG ^@ http://purl.uniprot.org/uniprot/A0A8C9NUS0 ^@ Similarity ^@ Belongs to the CD99 family. http://togogenome.org/gene/9135:LIPC ^@ http://purl.uniprot.org/uniprot/A0A8C9KU62 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9135:CCR7 ^@ http://purl.uniprot.org/uniprot/A0A8C9UBS0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:LOC103826647 ^@ http://purl.uniprot.org/uniprot/A0A8C9KRK7|||http://purl.uniprot.org/uniprot/A0A8C9KVC0 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9135:FLOT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NSX4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Endosome|||Heterooligomeric complex.|||Membrane http://togogenome.org/gene/9135:POMT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/9135:LOC103813361 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVI7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9135:SLC35D2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJ64 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:HHIP ^@ http://purl.uniprot.org/uniprot/A0A8C9NLS8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:HTT ^@ http://purl.uniprot.org/uniprot/A0A8C9NSR2|||http://purl.uniprot.org/uniprot/A0A8C9UH73 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the huntingtin family.|||Cytoplasm|||May play a role in microtubule-mediated transport or vesicle function.|||Nucleus http://togogenome.org/gene/9135:ATP8B1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9135:LOC103820837 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHF6 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9135:DDB2 ^@ http://purl.uniprot.org/uniprot/A0A8C9U5N3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DDB2/WDR76 family.|||Nucleus http://togogenome.org/gene/9135:EIF5 ^@ http://purl.uniprot.org/uniprot/A0A8C9UBH5 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/9135:DCTN4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunit 4 family.|||cell cortex|||centrosome|||sarcomere|||stress fiber http://togogenome.org/gene/9135:FAM8A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KW79 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:LOC103813978 ^@ http://purl.uniprot.org/uniprot/A0A8C9KQI3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9135:DAO ^@ http://purl.uniprot.org/uniprot/A0A8C9MWA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/9135:TNFRSF19 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQ04 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:LYPLA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NFX2 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/9135:PDZK1IP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJC8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:GET4 ^@ http://purl.uniprot.org/uniprot/A0A8C9UDR0 ^@ Similarity ^@ Belongs to the GET4 family. http://togogenome.org/gene/9135:DTNBP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9L117 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/9135:C1H11orf87 ^@ http://purl.uniprot.org/uniprot/A0A8C9MNF0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:OXR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MSG8 ^@ Similarity ^@ Belongs to the OXR1 family. http://togogenome.org/gene/9135:TMCO3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMA9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:MZT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQ72 ^@ Function|||Similarity ^@ Belongs to the MOZART1 family.|||Required for gamma-tubulin complex recruitment to the centrosome. http://togogenome.org/gene/9135:CALHM4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9135:IL1RAP ^@ http://purl.uniprot.org/uniprot/A0A8C9NQJ6 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9135:TCFL5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NNV9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:RNF168 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYD2 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNF168 family.|||Nucleus|||The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs). http://togogenome.org/gene/9135:ACER3 ^@ http://purl.uniprot.org/uniprot/A0A8C9KV30 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Membrane http://togogenome.org/gene/9135:CCDC65 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGL8 ^@ Subcellular Location Annotation ^@ flagellum axoneme http://togogenome.org/gene/9135:MTHFD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTN1 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.|||In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. http://togogenome.org/gene/9135:PEX2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9135:TNMD ^@ http://purl.uniprot.org/uniprot/A0A8C9MJ63 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/9135:TPRKB ^@ http://purl.uniprot.org/uniprot/A0A8C9MP26 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/9135:FUBP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NML0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9135:NR2E3 ^@ http://purl.uniprot.org/uniprot/A0A8C9UHH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9135:HNRNPH1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NA30 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/9135:F9 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJA4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9135:HOXD11 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9135:ARRB1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NWA1 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9135:ATP10B ^@ http://purl.uniprot.org/uniprot/A0A8C9N9T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9135:OPN3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N177 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:HDLBP ^@ http://purl.uniprot.org/uniprot/A0A8C9MX26 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9135:LOC103821188 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGC7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9135:SENP8 ^@ http://purl.uniprot.org/uniprot/A0A8C9NSU1 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9135:MCM10 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2S6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM10 family.|||Nucleus http://togogenome.org/gene/9135:LOC103816636 ^@ http://purl.uniprot.org/uniprot/A0A8C9U7Q0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9135:SSH1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MWX8 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/9135:FKTN ^@ http://purl.uniprot.org/uniprot/A0A8C9NP02 ^@ Similarity ^@ Belongs to the LicD transferase family. http://togogenome.org/gene/9135:RNF157 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHQ1|||http://purl.uniprot.org/uniprot/A0A8C9MHS2|||http://purl.uniprot.org/uniprot/A0A8C9MHT8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin ligase. http://togogenome.org/gene/9135:AVL9 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFX4 ^@ Subcellular Location Annotation ^@ Recycling endosome http://togogenome.org/gene/9135:CD82 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9135:DNAJC24 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZ72 ^@ Similarity ^@ Belongs to the DPH4 family. http://togogenome.org/gene/9135:CSF1R ^@ http://purl.uniprot.org/uniprot/A0A8C9NEQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:LOC103819550 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acyl-CoA reductase family.|||Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.|||Peroxisome membrane http://togogenome.org/gene/9135:LOC103823511 ^@ http://purl.uniprot.org/uniprot/A0A8C9MWT2 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9135:LOC103812638 ^@ http://purl.uniprot.org/uniprot/A0A8C9L4K8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9135:SERPINB1 ^@ http://purl.uniprot.org/uniprot/A0A8C9L451 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9135:LOC103823992 ^@ http://purl.uniprot.org/uniprot/A0A8C9UE50 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/9135:FABP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9KZD8 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9135:TGM4 ^@ http://purl.uniprot.org/uniprot/A0A8C9KVA3 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9135:ATG3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N5C3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG3 family.|||Cytoplasm http://togogenome.org/gene/9135:CRMP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KNW8 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9135:TXNRD2 ^@ http://purl.uniprot.org/uniprot/A0A8C9U8L9 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/9135:ANTXRL ^@ http://purl.uniprot.org/uniprot/A0A8C9NXR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATR family.|||Membrane http://togogenome.org/gene/9135:SLC22A3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8T4 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/9135:AHCY ^@ http://purl.uniprot.org/uniprot/A0A8C9N1J7 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/9135:MFSD14A ^@ http://purl.uniprot.org/uniprot/A0A8C9UF24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9135:LOC103813632 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUX5|||http://purl.uniprot.org/uniprot/A0A8C9UBK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/9135:SRP14 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCW4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP14 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm|||Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. http://togogenome.org/gene/9135:NOL12 ^@ http://purl.uniprot.org/uniprot/A0A8C9MM17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP17 family.|||nucleolus http://togogenome.org/gene/9135:LPIN2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N5F4 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/9135:MB ^@ http://purl.uniprot.org/uniprot/A0A8C9MKI6 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. http://togogenome.org/gene/9135:TDP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosyl-DNA phosphodiesterase family.|||Nucleus http://togogenome.org/gene/9135:MRTO4 ^@ http://purl.uniprot.org/uniprot/A0A8C9KXX0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the pre-60S ribosomal particle.|||Belongs to the universal ribosomal protein uL10 family.|||Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9135:SYNJ2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKB7 ^@ Similarity ^@ Belongs to the synaptojanin family.|||In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. http://togogenome.org/gene/9135:CXCL12 ^@ http://purl.uniprot.org/uniprot/A0A8C9NXK5 ^@ Similarity ^@ Belongs to the intercrine alpha (chemokine CxC) family. http://togogenome.org/gene/9135:RAX2 ^@ http://purl.uniprot.org/uniprot/A0A8C9L239 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9135:LCK ^@ http://purl.uniprot.org/uniprot/A0A8C9MNF4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9135:LOC103813390 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGZ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:FAM83H ^@ http://purl.uniprot.org/uniprot/A0A8C9L216 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9135:XRCC5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NF07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ku80 family.|||Nucleus|||Single-stranded DNA-dependent ATP-dependent helicase. http://togogenome.org/gene/9135:ORC4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYK4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC4 family.|||Component of the origin recognition complex (ORC) that binds origins of replication.|||Nucleus http://togogenome.org/gene/9135:ASF1A ^@ http://purl.uniprot.org/uniprot/A0A8C9NLA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/9135:ADHFE1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NFY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.|||Mitochondrion http://togogenome.org/gene/9135:FMO1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:BMP10 ^@ http://purl.uniprot.org/uniprot/A0A8C9UHR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/9135:ALDH8A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N763 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9135:UBN2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MT05 ^@ Similarity ^@ Belongs to the ubinuclein family. http://togogenome.org/gene/9135:TMCO4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MED7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMCO4 family.|||Membrane http://togogenome.org/gene/9135:LOC103813317 ^@ http://purl.uniprot.org/uniprot/A0A8C9UAN3 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9135:LOC103822502 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGL8 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9135:GRK5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NM30 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9135:FAS ^@ http://purl.uniprot.org/uniprot/A0A8C9NYC9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane raft http://togogenome.org/gene/9135:FZR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KWN3 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/9135:ADIPOR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9U9B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9135:ODC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGX2 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9135:SCTR ^@ http://purl.uniprot.org/uniprot/A0A8C9NAV7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:LOC103814920 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJ59 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:LOC103822488 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:ADA2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MT08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.|||Secreted http://togogenome.org/gene/9135:CPSF4 ^@ http://purl.uniprot.org/uniprot/A0A8C9UD63 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CPSF4/YTH1 family.|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex.|||Nucleus http://togogenome.org/gene/9135:SERINC3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NEZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9135:NRP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZC4 ^@ Caution|||Similarity ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:SLC37A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N9Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/9135:TBX20 ^@ http://purl.uniprot.org/uniprot/A0A8C9UDN0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9135:GDF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NVZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/9135:MSRA ^@ http://purl.uniprot.org/uniprot/A0A8C9UGK9 ^@ Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family. http://togogenome.org/gene/9135:B3GNT9 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQ14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9135:LOC103816830 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQ55 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9135:TBC1D7 ^@ http://purl.uniprot.org/uniprot/A0A8C9KR12 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Vesicle http://togogenome.org/gene/9135:FOXP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N189|||http://purl.uniprot.org/uniprot/A0A8C9UCK5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:PLRG1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDM1 ^@ Similarity ^@ Belongs to the WD repeat PRL1/PRL2 family. http://togogenome.org/gene/9135:TMEM170B ^@ http://purl.uniprot.org/uniprot/A0A8C9KX27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/9135:NIPA2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NSR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9135:PSMG2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UCH0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PSMG2 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.|||Forms a heterodimer with PSMG1. http://togogenome.org/gene/9135:SURF6 ^@ http://purl.uniprot.org/uniprot/A0A8C9MK82 ^@ Similarity ^@ Belongs to the SURF6 family. http://togogenome.org/gene/9135:BCL9L ^@ http://purl.uniprot.org/uniprot/A0A8C9NW19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BCL9 family.|||Nucleus http://togogenome.org/gene/9135:MINDY4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUG7|||http://purl.uniprot.org/uniprot/A0A8C9UA16 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/9135:TNFRSF21 ^@ http://purl.uniprot.org/uniprot/A0A8C9UG77 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:STEEP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NX58 ^@ Similarity ^@ Belongs to the STEEP1 family. http://togogenome.org/gene/9135:DPYSL2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NYJ4 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9135:RGS9BP ^@ http://purl.uniprot.org/uniprot/A0A8C9U7A7 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/9135:SLC26A2 ^@ http://purl.uniprot.org/uniprot/A0A8C9KYT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane|||Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion. http://togogenome.org/gene/9135:CXCR4 ^@ http://purl.uniprot.org/uniprot/A0A8C9N910 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Early endosome|||Endosome|||Late endosome|||Lysosome|||Membrane http://togogenome.org/gene/9135:GRPR ^@ http://purl.uniprot.org/uniprot/A0A8C9NLB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:RRM2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NFW0 ^@ Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family. http://togogenome.org/gene/9135:KCTD10 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUW3|||http://purl.uniprot.org/uniprot/A0A8C9U9W3 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/9135:SGTB ^@ http://purl.uniprot.org/uniprot/A0A8C9UEZ5 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/9135:FH ^@ http://purl.uniprot.org/uniprot/A0A8C9MSA0 ^@ Function|||Similarity ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.|||Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. http://togogenome.org/gene/9135:S100Z ^@ http://purl.uniprot.org/uniprot/A0A8C9MQ28 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9135:LOC103818639 ^@ http://purl.uniprot.org/uniprot/A0A8C9NIP8 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9135:NDUFS8 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCY5 ^@ Similarity ^@ Belongs to the complex I 23 kDa subunit family. http://togogenome.org/gene/9135:E2F8 ^@ http://purl.uniprot.org/uniprot/A0A8C9N6I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9135:AURKAIP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NVV3 ^@ Similarity ^@ Belongs to the mitochondrion-specific ribosomal protein mS38 family. http://togogenome.org/gene/9135:TMCC3 ^@ http://purl.uniprot.org/uniprot/A0A8C9UBA9 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9135:MID1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NHT8 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9135:ELF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9135:MFNG ^@ http://purl.uniprot.org/uniprot/A0A8C9ML66 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:SBNO2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTS6|||http://purl.uniprot.org/uniprot/A0A8C9U9X7 ^@ Similarity ^@ Belongs to the SBNO family. http://togogenome.org/gene/9135:GLE1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MU16 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GLE1 family.|||Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9135:SERPINA10 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZ18 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9135:TPST1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UBR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein sulfotransferase family.|||Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.|||Golgi apparatus membrane http://togogenome.org/gene/9135:SNRPD3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/9135:MLLT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGK0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:PTHLH ^@ http://purl.uniprot.org/uniprot/A0A8C9N609 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parathyroid hormone family.|||Secreted http://togogenome.org/gene/9135:LOC103825306 ^@ http://purl.uniprot.org/uniprot/A0A8C9L5U5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Secreted http://togogenome.org/gene/9135:JAGN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MR69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the jagunal family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:GJD4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZY0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9135:PIGP ^@ http://purl.uniprot.org/uniprot/A0A8C9UDZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGP family.|||Membrane|||Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. http://togogenome.org/gene/9135:UGT8 ^@ http://purl.uniprot.org/uniprot/A0A8C9N5D3 ^@ Similarity ^@ Belongs to the UDP-glycosyltransferase family. http://togogenome.org/gene/9135:PPP4R3B ^@ http://purl.uniprot.org/uniprot/A0A8C9NML7 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/9135:PYCR3 ^@ http://purl.uniprot.org/uniprot/A0A8C9KNN1 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/9135:DSE ^@ http://purl.uniprot.org/uniprot/A0A8C9NNU8 ^@ Similarity ^@ Belongs to the dermatan-sulfate isomerase family. http://togogenome.org/gene/9135:BTK ^@ http://purl.uniprot.org/uniprot/A0A8C9NXU9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9135:LOC103820244 ^@ http://purl.uniprot.org/uniprot/A0A8C9MNU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.|||Membrane http://togogenome.org/gene/9135:PLIN2 ^@ http://purl.uniprot.org/uniprot/A0A8C9KX54 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9135:ATP5F1E ^@ http://purl.uniprot.org/uniprot/A0A8C9NPU6 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ATPase epsilon family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/9135:SLC18B1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NBT9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:IL4R ^@ http://purl.uniprot.org/uniprot/A0A8C9MHP8 ^@ Function|||Similarity ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. http://togogenome.org/gene/9135:RNF146 ^@ http://purl.uniprot.org/uniprot/A0A8C9NN41 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.|||The WWE domain mediates non-covalent poly(ADP-ribose)-binding.|||Ubiquitinated; autoubiquitinated.|||cytosol http://togogenome.org/gene/9135:ADA ^@ http://purl.uniprot.org/uniprot/A0A8C9NGL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Cell junction|||Cell membrane|||Cytoplasmic vesicle lumen http://togogenome.org/gene/9135:LOC103817025 ^@ http://purl.uniprot.org/uniprot/A0A8C9N4N9 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/9135:SERPINB5 ^@ http://purl.uniprot.org/uniprot/A0A8C9MG24 ^@ Similarity ^@ Belongs to the serpin family. Ov-serpin subfamily. http://togogenome.org/gene/9135:BASP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLK0 ^@ Similarity ^@ Belongs to the BASP1 family. http://togogenome.org/gene/9135:MELTF ^@ http://purl.uniprot.org/uniprot/A0A8C9NS58 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transferrin family.|||Monomer.|||Secreted http://togogenome.org/gene/9135:NFIB ^@ http://purl.uniprot.org/uniprot/A0A8C9KX81|||http://purl.uniprot.org/uniprot/A0A8C9KZM2|||http://purl.uniprot.org/uniprot/A0A8C9MEJ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/9135:NEIL2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGI9 ^@ Similarity ^@ Belongs to the FPG family. http://togogenome.org/gene/9135:AKR1A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KWQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the aldo/keto reductase family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9135:DDX41 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKR1 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX41 subfamily. http://togogenome.org/gene/9135:ORAI2 ^@ http://purl.uniprot.org/uniprot/A0A8C9U9D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Orai family.|||Membrane http://togogenome.org/gene/9135:LOC103827204 ^@ http://purl.uniprot.org/uniprot/A0A8C9NFR3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transthyretin family.|||Homotetramer.|||Secreted|||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. http://togogenome.org/gene/9135:ADRA1A ^@ http://purl.uniprot.org/uniprot/A0A8C9NYC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Membrane|||Nucleus membrane|||caveola http://togogenome.org/gene/9135:PPP1R21 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDB2 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9135:LOC103825436 ^@ http://purl.uniprot.org/uniprot/A0A8C9KYB6 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9135:CEP170B ^@ http://purl.uniprot.org/uniprot/A0A8C9MV07|||http://purl.uniprot.org/uniprot/A0A8C9MV21|||http://purl.uniprot.org/uniprot/A0A8C9U9Y7 ^@ Similarity ^@ Belongs to the CEP170 family. http://togogenome.org/gene/9135:SMC4 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family.|||Chromosome|||Nucleus http://togogenome.org/gene/9135:LOC103812446 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9135:KIF21A ^@ http://purl.uniprot.org/uniprot/A0A8C9MPC0|||http://purl.uniprot.org/uniprot/A0A8C9U7N1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9135:DCBLD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NIF9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:LPAR5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NEH0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:GALM ^@ http://purl.uniprot.org/uniprot/A0A8C9KTT0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the aldose epimerase family.|||Monomer.|||Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. http://togogenome.org/gene/9135:EZR ^@ http://purl.uniprot.org/uniprot/A0A8C9NLK8 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9135:ADI1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UEV4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acireductone dioxygenase (ARD) family.|||Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.|||Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.|||Cell membrane|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/9135:LOC103815785 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCR2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:TRMT2A ^@ http://purl.uniprot.org/uniprot/A0A8C9MN38 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:PHKG1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MW19 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily.|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/9135:TLX1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NW32 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:POLR2C ^@ http://purl.uniprot.org/uniprot/A0A8C9UB45 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/9135:GAR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UFZ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GAR1 family.|||Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).|||Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.|||nucleolus http://togogenome.org/gene/9135:PPP2R5C ^@ http://purl.uniprot.org/uniprot/A0A8C9MX11|||http://purl.uniprot.org/uniprot/A0A8C9UBZ9 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family. http://togogenome.org/gene/9135:CASP6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDD1 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9135:SLC7A3 ^@ http://purl.uniprot.org/uniprot/A0A8C9UIP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:AQP4 ^@ http://purl.uniprot.org/uniprot/A0A8C9UEZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9135:UBR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N305 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/9135:SMU1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NB30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SMU1 family.|||Nucleus speckle http://togogenome.org/gene/9135:PHACTR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NM90|||http://purl.uniprot.org/uniprot/A0A8C9NNN5 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/9135:GTF2H5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJK5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex.|||In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.|||Nucleus http://togogenome.org/gene/9135:USP22 ^@ http://purl.uniprot.org/uniprot/A0A8C9N4D9 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9135:RNF135 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJ14 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9135:GTPBP10 ^@ http://purl.uniprot.org/uniprot/A0A8C9NE42 ^@ Similarity ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. http://togogenome.org/gene/9135:FAXC ^@ http://purl.uniprot.org/uniprot/A0A8C9L2I7 ^@ Similarity ^@ Belongs to the FAX family. http://togogenome.org/gene/9135:TUBD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8W6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Nucleus|||centriole|||cilium http://togogenome.org/gene/9135:PPIL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVA8 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9135:SVOP ^@ http://purl.uniprot.org/uniprot/A0A8C9MXR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9135:LOC103816031 ^@ http://purl.uniprot.org/uniprot/A0A8C9MP90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/9135:NAA60 ^@ http://purl.uniprot.org/uniprot/A0A8C9ND90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA60 subfamily.|||Golgi apparatus membrane http://togogenome.org/gene/9135:SUPT4H1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLZ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT4 family.|||Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.|||Nucleus http://togogenome.org/gene/9135:SMAD5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NC62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:SLC6A4 ^@ http://purl.uniprot.org/uniprot/A0A8C9N4I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.|||Cell membrane|||Endomembrane system|||Endosome membrane|||Membrane|||Synapse|||focal adhesion|||neuron projection http://togogenome.org/gene/9135:PSKH1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTT4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:CPLX3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9135:RPS21 ^@ http://purl.uniprot.org/uniprot/A0A8C9NN54 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS21 family.|||Component of the 40S small ribosomal subunit.|||Endoplasmic reticulum|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/9135:RPLP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NP01 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/9135:CTBP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NET7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/9135:LOC103827193 ^@ http://purl.uniprot.org/uniprot/A0A8C9NBU6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transthyretin family.|||Homotetramer.|||Secreted|||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. http://togogenome.org/gene/9135:INTS13 ^@ http://purl.uniprot.org/uniprot/A0A8C9N4V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the asunder family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:AFG3L2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZT0 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/9135:RIPOR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVR8|||http://purl.uniprot.org/uniprot/A0A8C9MYB6 ^@ Similarity ^@ Belongs to the RIPOR family. http://togogenome.org/gene/9135:CHGB ^@ http://purl.uniprot.org/uniprot/A0A8C9KTQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/9135:DENND6A ^@ http://purl.uniprot.org/uniprot/A0A8C9MKV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND6 family.|||Recycling endosome http://togogenome.org/gene/9135:SNX5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCD9 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/9135:TENT5C ^@ http://purl.uniprot.org/uniprot/A0A8C9ND96 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9135:FERMT2 ^@ http://purl.uniprot.org/uniprot/A0A8C9KUX5|||http://purl.uniprot.org/uniprot/A0A8C9KY44|||http://purl.uniprot.org/uniprot/A0A8C9L6P2 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/9135:GALC ^@ http://purl.uniprot.org/uniprot/A0A8C9N353 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 59 family. http://togogenome.org/gene/9135:LOC103826650 ^@ http://purl.uniprot.org/uniprot/A0A8C9KVI7 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9135:NDUFV3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCD2 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.|||Belongs to the complex I NDUFV3 subunit family.|||Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. http://togogenome.org/gene/9135:HOXD4 ^@ http://purl.uniprot.org/uniprot/A0A8C9UHL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9135:SLC16A8 ^@ http://purl.uniprot.org/uniprot/A0A8C9MM77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9135:LOC103812363 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHB9 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9135:LOC103827264 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9135:COQ10B ^@ http://purl.uniprot.org/uniprot/A0A8C9MH96 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/9135:CCNK ^@ http://purl.uniprot.org/uniprot/A0A8C9MVQ9 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9135:AIF1L ^@ http://purl.uniprot.org/uniprot/A0A8C9U839 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/9135:LOC103817479 ^@ http://purl.uniprot.org/uniprot/A0A8C9UEY8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:SNAPC3 ^@ http://purl.uniprot.org/uniprot/A0A8C9L365 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAPC3/SRD2 family.|||Nucleus|||Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.|||Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. http://togogenome.org/gene/9135:FAM167A ^@ http://purl.uniprot.org/uniprot/A0A8C9NM82 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/9135:NPC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UDN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/9135:CTNNB1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KV31 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9135:LMOD3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYV7 ^@ Subcellular Location Annotation ^@ cytoskeleton|||sarcomere http://togogenome.org/gene/9135:ZP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N5X9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:LOC103826296 ^@ http://purl.uniprot.org/uniprot/A0A8C9KPH2 ^@ Subcellular Location Annotation ^@ centrosome|||perinuclear region http://togogenome.org/gene/9135:HEBP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N937 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/9135:DDX1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NIB7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DDX1 subfamily.|||Cytoplasmic granule|||RNA helicase.|||The helicase domain is involved in the stimulation of RELA transcriptional activity. http://togogenome.org/gene/9135:LOC103822342 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKB9 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9135:CPB2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGH0|||http://purl.uniprot.org/uniprot/A0A8C9NHZ4 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9135:TIGD5 ^@ http://purl.uniprot.org/uniprot/A0A8C9MDL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tigger transposable element derived protein family.|||Nucleus http://togogenome.org/gene/9135:OLA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NSE0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.|||Cytoplasm|||Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.|||Monomer.|||Nucleus|||nucleolus http://togogenome.org/gene/9135:CPNE3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGP1 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9135:LOC103816800 ^@ http://purl.uniprot.org/uniprot/A0A8C9ML56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the borealin family.|||centromere http://togogenome.org/gene/9135:TTC39A ^@ http://purl.uniprot.org/uniprot/A0A8C9MJQ2 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/9135:SMARCD3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N7Q5 ^@ Similarity ^@ Belongs to the SMARCD family. http://togogenome.org/gene/9135:CYFIP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NFF1 ^@ Similarity ^@ Belongs to the CYFIP family. http://togogenome.org/gene/9135:DCSTAMP ^@ http://purl.uniprot.org/uniprot/A0A8C9UAZ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:PMM1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MS75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/9135:TMEM150A ^@ http://purl.uniprot.org/uniprot/A0A8C9NY57 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:NSG2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGN5 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/9135:USP33 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family. USP20/USP33 subfamily.|||centrosome|||perinuclear region http://togogenome.org/gene/9135:FTSJ3 ^@ http://purl.uniprot.org/uniprot/A0A8C9UE79 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.|||Interacts with NIP7.|||Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.|||nucleolus http://togogenome.org/gene/9135:CRHBP ^@ http://purl.uniprot.org/uniprot/A0A8C9MP73 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CRF-binding protein family.|||Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.|||Secreted http://togogenome.org/gene/9135:PRPSAP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHM3 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/9135:NPY1R ^@ http://purl.uniprot.org/uniprot/A0A8C9N749 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:LOC103825989 ^@ http://purl.uniprot.org/uniprot/A0A8C9NF53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9135:SSU72 ^@ http://purl.uniprot.org/uniprot/A0A8C9UIG3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSU72 phosphatase family.|||Nucleus|||Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. http://togogenome.org/gene/9135:GRP ^@ http://purl.uniprot.org/uniprot/A0A8C9MHL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bombesin/neuromedin-B/ranatensin family.|||Secreted http://togogenome.org/gene/9135:SUMO1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MG51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/9135:SLC16A9 ^@ http://purl.uniprot.org/uniprot/A0A8C9MK41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:LOC103827281 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:TPM3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NH29|||http://purl.uniprot.org/uniprot/A0A8C9NHX5|||http://purl.uniprot.org/uniprot/A0A8C9UFH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9135:SLC35B3 ^@ http://purl.uniprot.org/uniprot/A0A8C9KWJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9135:MTMR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKM3|||http://purl.uniprot.org/uniprot/A0A8C9U5D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/9135:LOC103820800 ^@ http://purl.uniprot.org/uniprot/A0A8C9NVZ8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/9135:GCG ^@ http://purl.uniprot.org/uniprot/A0A8C9NM54 ^@ Similarity ^@ Belongs to the glucagon family. http://togogenome.org/gene/9135:HSPA2 ^@ http://purl.uniprot.org/uniprot/A0A8C9U9K3 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9135:PCMTD2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMG1 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/9135:SEPTIN12 ^@ http://purl.uniprot.org/uniprot/A0A8C9UFR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cytoplasm http://togogenome.org/gene/9135:KIF11 ^@ http://purl.uniprot.org/uniprot/A0A8C9UIN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.|||spindle pole http://togogenome.org/gene/9135:SGO1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shugoshin family.|||centromere http://togogenome.org/gene/9135:TNFSF13B ^@ http://purl.uniprot.org/uniprot/A0A8C9NQU9 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9135:TPST2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein sulfotransferase family.|||Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.|||Golgi apparatus membrane http://togogenome.org/gene/9135:PDGFRB ^@ http://purl.uniprot.org/uniprot/A0A8C9NCM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:SEPTIN5 ^@ http://purl.uniprot.org/uniprot/A0A8C9MNQ1 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/9135:TFDP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9135:HADHB ^@ http://purl.uniprot.org/uniprot/A0A8C9NLJ3 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9135:DENND10 ^@ http://purl.uniprot.org/uniprot/A0A8C9NL94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND10 family.|||Endosome|||Late endosome http://togogenome.org/gene/9135:FNIP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N9H2|||http://purl.uniprot.org/uniprot/A0A8C9NBA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNIP family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9135:ABCG5 ^@ http://purl.uniprot.org/uniprot/A0A8C9UD36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9135:DAG1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UFS7 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.|||Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.|||cytoskeleton|||extracellular space|||nucleoplasm|||sarcolemma http://togogenome.org/gene/9135:LOC103820320 ^@ http://purl.uniprot.org/uniprot/A0A8C9NA62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/9135:FAM3C ^@ http://purl.uniprot.org/uniprot/A0A8C9KUC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9135:HAL ^@ http://purl.uniprot.org/uniprot/A0A8C9MW73 ^@ Similarity ^@ Belongs to the PAL/histidase family. http://togogenome.org/gene/9135:LOC103814300 ^@ http://purl.uniprot.org/uniprot/A0A8C9UEM7 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9135:LOC103826768 ^@ http://purl.uniprot.org/uniprot/A0A8C9U920 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9135:GASK1B ^@ http://purl.uniprot.org/uniprot/A0A8C9NB63 ^@ Similarity ^@ Belongs to the GASK family. http://togogenome.org/gene/9135:CFI ^@ http://purl.uniprot.org/uniprot/A0A8C9NHQ4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:LOC103815196 ^@ http://purl.uniprot.org/uniprot/A0A8C9MSY3 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9135:CHRNG ^@ http://purl.uniprot.org/uniprot/A0A8C9NKU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9135:MED6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NIE6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 6 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9135:IDI1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UC81 ^@ Function|||Similarity ^@ Belongs to the IPP isomerase type 1 family.|||Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/9135:ALOX5AP ^@ http://purl.uniprot.org/uniprot/A0A8C9MW76 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:SFT2D2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UD90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/9135:PSMA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQE4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9135:DOHH ^@ http://purl.uniprot.org/uniprot/A0A8C9MF39 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the deoxyhypusine hydroxylase family.|||Binds 2 Fe(2+) ions per subunit.|||Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. http://togogenome.org/gene/9135:MLF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2I3|||http://purl.uniprot.org/uniprot/A0A8C9UDB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLF family.|||Cytoplasm http://togogenome.org/gene/9135:GGT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyltransferase family.|||Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.|||Membrane http://togogenome.org/gene/9135:CPZ ^@ http://purl.uniprot.org/uniprot/A0A8C9NSI7 ^@ Caution|||Similarity ^@ Belongs to the peptidase M14 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:CD36 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1M9 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/9135:NPY2R ^@ http://purl.uniprot.org/uniprot/A0A8C9NDG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:CCNF ^@ http://purl.uniprot.org/uniprot/A0A8C9NG19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family.|||Nucleus|||centriole|||perinuclear region http://togogenome.org/gene/9135:G6PC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9135:SIAH1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMD9 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9135:CDK3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHE7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:ROMO1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGR2 family.|||Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.|||Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.|||Mitochondrion inner membrane http://togogenome.org/gene/9135:INTS10 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 10 family.|||Nucleus http://togogenome.org/gene/9135:TUBGCP4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NIY9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/9135:DBH ^@ http://purl.uniprot.org/uniprot/A0A8C9MJM4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the copper type II ascorbate-dependent monooxygenase family.|||Conversion of dopamine to noradrenaline.|||Homotetramer; composed of two disulfide-linked dimers.|||chromaffin granule lumen|||chromaffin granule membrane|||secretory vesicle lumen|||secretory vesicle membrane http://togogenome.org/gene/9135:ARPC1A ^@ http://purl.uniprot.org/uniprot/A0A8C9N3H9 ^@ Function|||Similarity ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. http://togogenome.org/gene/9135:NEK6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NUM2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:CDK7 ^@ http://purl.uniprot.org/uniprot/A0A8C9UA44 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/9135:SUMF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MW55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase-modifying factor family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9135:AK1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UBE7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK1 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9135:NDUFAF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFZ2 ^@ Function|||Similarity ^@ As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the CIA30 family. http://togogenome.org/gene/9135:LOC103816381 ^@ http://purl.uniprot.org/uniprot/A0A8C9NX31|||http://purl.uniprot.org/uniprot/A0A8C9UI23 ^@ Similarity ^@ Belongs to the PICALM/SNAP91 family. http://togogenome.org/gene/9135:GDF5 ^@ http://purl.uniprot.org/uniprot/A0A8C9UEH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/9135:UBE2E1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQJ2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9135:NFYB ^@ http://purl.uniprot.org/uniprot/A0A8C9MGE8 ^@ Function|||Similarity ^@ Belongs to the NFYB/HAP3 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. http://togogenome.org/gene/9135:EXTL2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9135:TK1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8V2 ^@ Similarity ^@ Belongs to the thymidine kinase family. http://togogenome.org/gene/9135:GGPS1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLE1 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9135:SLC7A11 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:STX19 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKC4 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9135:LOC103819047 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUZ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family. Highly divergent.|||Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.|||Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.|||Secreted http://togogenome.org/gene/9135:WARS2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N9U2|||http://purl.uniprot.org/uniprot/A0A8C9UED5 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9135:PPP1R15B ^@ http://purl.uniprot.org/uniprot/A0A8C9N4N4 ^@ Similarity ^@ Belongs to the PPP1R15 family. http://togogenome.org/gene/9135:YAE1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NWC8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9135:LOC103817883 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAX5 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9135:SERPIND1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MML6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9135:ARPP19 ^@ http://purl.uniprot.org/uniprot/A0A8C9KQQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. http://togogenome.org/gene/9135:FRG1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N727 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FRG1 family.|||Cajal body|||nucleolus http://togogenome.org/gene/9135:FMC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MSX6 ^@ Similarity ^@ Belongs to the FMC1 family. http://togogenome.org/gene/9135:SMPD2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UHE0 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/9135:LOC103814634 ^@ http://purl.uniprot.org/uniprot/A0A8C9N6X9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:RECQL ^@ http://purl.uniprot.org/uniprot/A0A8C9MY27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RecQ subfamily.|||Nucleus http://togogenome.org/gene/9135:WNT6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9135:PIAS2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NSS5 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/9135:LRRC8D ^@ http://purl.uniprot.org/uniprot/A0A8C9UGQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:USP18 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRR8 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9135:LOC103812327 ^@ http://purl.uniprot.org/uniprot/A0A8C9NTL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm http://togogenome.org/gene/9135:IL13RA2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NUW0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:CRHR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MV84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Membrane http://togogenome.org/gene/9135:NBL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KWD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/9135:PKP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UBV7 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9135:DTX3L ^@ http://purl.uniprot.org/uniprot/A0A8C9NCE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/9135:TGFBR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NTP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9135:NMT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZ49 ^@ Function|||Similarity ^@ Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.|||Belongs to the NMT family. http://togogenome.org/gene/9135:CAV3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/9135:LOC103816499 ^@ http://purl.uniprot.org/uniprot/A0A8C9UI68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/9135:HYCC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NLV6|||http://purl.uniprot.org/uniprot/A0A8C9NNP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9135:LOC103814362 ^@ http://purl.uniprot.org/uniprot/A0A8C9UFP2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:PRKD3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDJ4 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by DAG and phorbol esters.|||Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9135:CERCAM ^@ http://purl.uniprot.org/uniprot/A0A8C9UBB1 ^@ Similarity ^@ Belongs to the glycosyltransferase 25 family. http://togogenome.org/gene/9135:STEAP4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NE24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9135:LOC103824233 ^@ http://purl.uniprot.org/uniprot/A0A8C9NXB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9135:TAF12 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF12 family.|||Nucleus http://togogenome.org/gene/9135:SNAP23 ^@ http://purl.uniprot.org/uniprot/A0A8C9L546 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||synaptosome http://togogenome.org/gene/9135:TRAK1 ^@ http://purl.uniprot.org/uniprot/A0A8C9L575 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the milton family.|||Early endosome|||Mitochondrion http://togogenome.org/gene/9135:GPR182 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJ10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:UBA52 ^@ http://purl.uniprot.org/uniprot/A0A8C9NF23 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Nucleus http://togogenome.org/gene/9135:ADCY7 ^@ http://purl.uniprot.org/uniprot/A0A8C9U703 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9135:EME1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KTD0|||http://purl.uniprot.org/uniprot/A0A8C9KVP4 ^@ Similarity ^@ Belongs to the EME1/MMS4 family. http://togogenome.org/gene/9135:RARB ^@ http://purl.uniprot.org/uniprot/A0A8C9NKE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9135:COL4A6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NUT3 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/9135:TRMT5 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRK4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM5 / TYW2 family.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Mitochondrion matrix|||Monomer.|||Nucleus|||Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. http://togogenome.org/gene/9135:NAT9 ^@ http://purl.uniprot.org/uniprot/A0A8C9KVV5 ^@ Similarity ^@ Belongs to the acetyltransferase family. GNAT subfamily. http://togogenome.org/gene/9135:RBM5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NW74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBM5/RBM10 family.|||Nucleus http://togogenome.org/gene/9135:EXOC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N4C6|||http://purl.uniprot.org/uniprot/A0A8C9UCL3 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/9135:HMGB3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/9135:RPL22L1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N616 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/9135:ATP11B ^@ http://purl.uniprot.org/uniprot/A0A8C9UF82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9135:LOC103812489 ^@ http://purl.uniprot.org/uniprot/A0A8C9L164 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/9135:PAQR3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MN71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9135:SQSTM1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAA1|||http://purl.uniprot.org/uniprot/A0A8C9NCJ8 ^@ Subcellular Location Annotation ^@ autophagosome http://togogenome.org/gene/9135:GPLD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KWB3|||http://purl.uniprot.org/uniprot/A0A8C9MEW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPLD1 family.|||Secreted http://togogenome.org/gene/9135:ZNF326 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKK1|||http://purl.uniprot.org/uniprot/A0A8C9NMB8 ^@ Similarity ^@ Belongs to the AKAP95 family. http://togogenome.org/gene/9135:ACVR2A ^@ http://purl.uniprot.org/uniprot/A0A8C9N1Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9135:PROM1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KVW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/9135:TRAPPC11 ^@ http://purl.uniprot.org/uniprot/A0A8C9N446 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPPC11 family.|||Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.|||cis-Golgi network http://togogenome.org/gene/9135:TAF1B ^@ http://purl.uniprot.org/uniprot/A0A8C9NBC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRN7/TAF1B family.|||nucleolus http://togogenome.org/gene/9135:HTR2B ^@ http://purl.uniprot.org/uniprot/A0A8C9UGM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||synaptosome http://togogenome.org/gene/9135:PARVA ^@ http://purl.uniprot.org/uniprot/A0A8C9NY53 ^@ Similarity ^@ Belongs to the parvin family. http://togogenome.org/gene/9135:FAM163A ^@ http://purl.uniprot.org/uniprot/A0A8C9N7H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/9135:PTPN14 ^@ http://purl.uniprot.org/uniprot/A0A8C9U923 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/9135:RFTN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:FZD10 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Membrane http://togogenome.org/gene/9135:DNAJA4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDT4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:SLC26A9 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8P5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Ion transporter that can act both as an ion channel and anion exchanger. Mainly acts as a chloride channel, which mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane. Also acts as a DIDS- and thiosulfate- sensitive anion exchanger the exchange of chloride for bicarbonate ions across the cell membrane.|||Membrane http://togogenome.org/gene/9135:CNRIP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9L2Y1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CNRIP family.|||Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.|||Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. http://togogenome.org/gene/9135:VKORC1L1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VKOR family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:NDUFA6 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTA6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9135:IDS ^@ http://purl.uniprot.org/uniprot/A0A8C9NVG1 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9135:AP5M1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQT4 ^@ Subcellular Location Annotation|||Subunit ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. http://togogenome.org/gene/9135:NAA35 ^@ http://purl.uniprot.org/uniprot/A0A8C9U6T0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MAK10 family.|||Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.|||Cytoplasm http://togogenome.org/gene/9135:GOLT1A ^@ http://purl.uniprot.org/uniprot/A0A8C9N7E2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/9135:EPHA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPJ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:CMKLR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:NBR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVY9 ^@ Subcellular Location Annotation ^@ autophagosome http://togogenome.org/gene/9135:LOC103821609 ^@ http://purl.uniprot.org/uniprot/A0A8C9MXJ8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9135:DAD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MS80 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAD/OST2 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9135:CRKL ^@ http://purl.uniprot.org/uniprot/A0A8C9MJA6 ^@ Similarity ^@ Belongs to the CRK family. http://togogenome.org/gene/9135:FSHR ^@ http://purl.uniprot.org/uniprot/A0A8C9NE96 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.|||Membrane http://togogenome.org/gene/9135:USP44 ^@ http://purl.uniprot.org/uniprot/A0A8C9MXH2 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9135:EXO1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N0H2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.|||Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Nucleus http://togogenome.org/gene/9135:NAGA ^@ http://purl.uniprot.org/uniprot/A0A8C9MSD1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/9135:FKBP4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRC2 ^@ Subcellular Location Annotation ^@ Mitochondrion|||cytoskeleton|||cytosol http://togogenome.org/gene/9135:STX6 ^@ http://purl.uniprot.org/uniprot/A0A8C9KPW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Golgi apparatus membrane http://togogenome.org/gene/9135:LOC103816492 ^@ http://purl.uniprot.org/uniprot/A0A8C9NS93 ^@ Similarity ^@ Belongs to the SUA5 family. http://togogenome.org/gene/9135:TDO2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCB7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the tryptophan 2,3-dioxygenase family.|||Binds 1 heme group per subunit.|||Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.|||Homotetramer. Dimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:PGAP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NWQ5|||http://purl.uniprot.org/uniprot/A0A8C9NX86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP2 family.|||Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.|||Membrane http://togogenome.org/gene/9135:POLR3K ^@ http://purl.uniprot.org/uniprot/A0A8C9NBT2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/9135:KPNA5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMH6 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/9135:QPCT ^@ http://purl.uniprot.org/uniprot/A0A8C9UFC3 ^@ Similarity ^@ Belongs to the glutaminyl-peptide cyclotransferase family. http://togogenome.org/gene/9135:LOC103822348 ^@ http://purl.uniprot.org/uniprot/A0A8C9L1C3 ^@ Similarity ^@ Belongs to the GST superfamily. Mu family. http://togogenome.org/gene/9135:PRKX ^@ http://purl.uniprot.org/uniprot/A0A8C9MPS6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:NCAPG ^@ http://purl.uniprot.org/uniprot/A0A8C9MEE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND3 (condensin subunit 3) family.|||Chromosome http://togogenome.org/gene/9135:VPS18 ^@ http://purl.uniprot.org/uniprot/A0A8C9MG61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS18 family.|||Membrane http://togogenome.org/gene/9135:HINT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJ94 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/9135:PTPN2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZL9 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. http://togogenome.org/gene/9135:ESRRG ^@ http://purl.uniprot.org/uniprot/A0A8C9MSD7|||http://purl.uniprot.org/uniprot/A0A8C9MSQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9135:CDA ^@ http://purl.uniprot.org/uniprot/A0A8C9MEB1 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/9135:ATXN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9L149 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATXN1 family.|||Nucleus http://togogenome.org/gene/9135:MYLK ^@ http://purl.uniprot.org/uniprot/A0A8C9N947 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. http://togogenome.org/gene/9135:LOC103823857 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYK2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:RSPO3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NN51 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9135:GCLC ^@ http://purl.uniprot.org/uniprot/A0A8C9NBT8 ^@ Similarity ^@ Belongs to the glutamate--cysteine ligase type 3 family. http://togogenome.org/gene/9135:ERGIC3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCG1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/9135:LSM4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPA8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/9135:ANXA8L1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UIW5 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9135:ENKUR ^@ http://purl.uniprot.org/uniprot/A0A8C9N7N2 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9135:SLC9A9 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/9135:PRKN ^@ http://purl.uniprot.org/uniprot/A0A8C9NBE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBR family. Parkin subfamily.|||Forms an E3 ubiquitin ligase complex.|||Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.|||Mitochondrion|||cytosol http://togogenome.org/gene/9135:LOC103819267 ^@ http://purl.uniprot.org/uniprot/A0A8C9NN98 ^@ Similarity ^@ Belongs to the RIN (Ras interaction/interference) family. http://togogenome.org/gene/9135:TADA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NS21 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TADA1 family.|||Nucleus|||Probably involved in transcriptional regulation. http://togogenome.org/gene/9135:LOC103819133 ^@ http://purl.uniprot.org/uniprot/A0A8C9MK25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF1 family.|||Mitochondrion inner membrane|||Probably involved in the biogenesis of the COX complex. http://togogenome.org/gene/9135:PGM1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVU0 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9135:B3GAT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N751 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9135:INPP5K ^@ http://purl.uniprot.org/uniprot/A0A8C9MWB2 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family. http://togogenome.org/gene/9135:RGS4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NZ47 ^@ Function ^@ Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. http://togogenome.org/gene/9135:TRMT2B ^@ http://purl.uniprot.org/uniprot/A0A8C9NX72 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:GJD2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NBH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9135:LARS1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KUJ2 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9135:GPHB5 ^@ http://purl.uniprot.org/uniprot/A0A8C9MSM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9135:RAB3IL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N369 ^@ Similarity ^@ Belongs to the SEC2 family. http://togogenome.org/gene/9135:TMEM47 ^@ http://purl.uniprot.org/uniprot/A0A8C9UEJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/9135:L3MBTL3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJU6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:LOC103817973 ^@ http://purl.uniprot.org/uniprot/A0A8C9KW65 ^@ Similarity ^@ Belongs to the gonadal family. http://togogenome.org/gene/9135:EFEMP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NM68 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:MCEE ^@ http://purl.uniprot.org/uniprot/A0A8C9NSZ5 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/9135:LOC108963022 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVA6 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/9135:LOC103819066 ^@ http://purl.uniprot.org/uniprot/A0A8C9N955 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:IL2RG ^@ http://purl.uniprot.org/uniprot/A0A8C9NSS2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:ETFA ^@ http://purl.uniprot.org/uniprot/A0A8C9NEA0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/9135:TRH ^@ http://purl.uniprot.org/uniprot/A0A8C9NUM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRH family.|||Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.|||Secreted http://togogenome.org/gene/9135:ISCU ^@ http://purl.uniprot.org/uniprot/A0A8C9MV42 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/9135:SLC25A47 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9135:GPN2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MY73 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/9135:SLC16A3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N911 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9135:TICAM1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MW61 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Homodimer. Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1.|||Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.|||Mitochondrion|||The N-terminal region is essential for activation of the IFNB promoter activity.|||autophagosome|||cytosol http://togogenome.org/gene/9135:HYLS1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NWA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HYLS1 family.|||centriole|||cilium http://togogenome.org/gene/9135:SCARB1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N7F8|||http://purl.uniprot.org/uniprot/A0A8C9NAB3 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/9135:TACC3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NNK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACC family.|||Cytoplasm http://togogenome.org/gene/9135:NELL2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MDM1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:CAMK1D ^@ http://purl.uniprot.org/uniprot/A0A8C9UDL4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:TOP3A ^@ http://purl.uniprot.org/uniprot/A0A8C9N1E4 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/9135:CLDN16 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQI7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9135:COG2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJ80 ^@ Similarity ^@ Belongs to the COG2 family. http://togogenome.org/gene/9135:SIX3 ^@ http://purl.uniprot.org/uniprot/A0A8C9UE81 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:DNAJA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAR5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:LOC103818711 ^@ http://purl.uniprot.org/uniprot/A0A8C9UH42 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9135:LEPROT ^@ http://purl.uniprot.org/uniprot/A0A8C9MVT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/9135:CNIH3 ^@ http://purl.uniprot.org/uniprot/A0A8C9UHI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9135:TMEM184A ^@ http://purl.uniprot.org/uniprot/A0A8C9N2N7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:GJA9 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJQ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9135:LIPI ^@ http://purl.uniprot.org/uniprot/A0A8C9N8Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9135:P2RX4 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2B4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9135:KREMEN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRV5 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. http://togogenome.org/gene/9135:STMN2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFR2 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9135:ORC6 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC6 family.|||Nucleus http://togogenome.org/gene/9135:MRPL14 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKS8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/9135:TFRC ^@ http://purl.uniprot.org/uniprot/A0A8C9NNC8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.|||Homodimer; disulfide-linked.|||Melanosome|||Membrane|||Stearoylated. http://togogenome.org/gene/9135:TELO2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGJ9|||http://purl.uniprot.org/uniprot/A0A8C9MGN1 ^@ Similarity ^@ Belongs to the TEL2 family. http://togogenome.org/gene/9135:DGKE ^@ http://purl.uniprot.org/uniprot/A0A8C9NMF9 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9135:LOC103822889 ^@ http://purl.uniprot.org/uniprot/A0A8C9KZY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. http://togogenome.org/gene/9135:LOC103825221 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9135:VPS37C ^@ http://purl.uniprot.org/uniprot/A0A8C9N7K6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/9135:GPR17 ^@ http://purl.uniprot.org/uniprot/A0A8C9MI14 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:VPS29 ^@ http://purl.uniprot.org/uniprot/A0A8C9N066 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.|||Belongs to the VPS29 family.|||Endosome membrane http://togogenome.org/gene/9135:LOC103820330 ^@ http://purl.uniprot.org/uniprot/A0A8C9N5V9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:ATP6V0D1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRR7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9135:CDC42EP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9135:KDR ^@ http://purl.uniprot.org/uniprot/A0A8C9N450 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:CIAO3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MU13 ^@ Similarity ^@ Belongs to the NARF family. http://togogenome.org/gene/9135:BCL2A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQN0 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9135:CRIPT ^@ http://purl.uniprot.org/uniprot/A0A8C9N6D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRIPT family.|||Cytoplasm http://togogenome.org/gene/9135:CUL4B ^@ http://purl.uniprot.org/uniprot/A0A8C9NSY6 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9135:APPL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGA5 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Membrane|||Nucleus|||phagosome|||ruffle http://togogenome.org/gene/9135:CNOT9 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT9 family.|||P-body http://togogenome.org/gene/9135:LOC103826648 ^@ http://purl.uniprot.org/uniprot/A0A8C9L295 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9135:ACO1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Cytoplasm http://togogenome.org/gene/9135:BCO1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTI2 ^@ Cofactor|||Similarity ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/9135:DOCK2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N5Y3 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9135:LOC103826032 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJ99 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9135:FXR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDU2|||http://purl.uniprot.org/uniprot/A0A8C9NDV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMR1 family.|||Cytoplasmic ribonucleoprotein granule http://togogenome.org/gene/9135:KYNU ^@ http://purl.uniprot.org/uniprot/A0A8C9N179 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:TMEM177 ^@ http://purl.uniprot.org/uniprot/A0A8C9UFG0 ^@ Function|||Similarity ^@ Belongs to the TMEM177 family.|||Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein. http://togogenome.org/gene/9135:SLC35A3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NH70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9135:GLYCTK ^@ http://purl.uniprot.org/uniprot/A0A8C9NV52 ^@ Similarity ^@ Belongs to the glycerate kinase type-2 family. http://togogenome.org/gene/9135:HNF4G ^@ http://purl.uniprot.org/uniprot/A0A8C9U152 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9135:HSPB3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N3K8 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/9135:SLC8A3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:TCAF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQE9 ^@ Similarity ^@ Belongs to the TCAF family. http://togogenome.org/gene/9135:CDKN3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFH4 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/9135:USE1 ^@ http://purl.uniprot.org/uniprot/A0A8C9U4Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the USE1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:HYCC2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9135:PPM1K ^@ http://purl.uniprot.org/uniprot/A0A8C9NQ40 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9135:BARX2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NYE0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:VPS13B ^@ http://purl.uniprot.org/uniprot/A0A8C9U7M4 ^@ Similarity ^@ Belongs to the VPS13 family. http://togogenome.org/gene/9135:MFAP5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MFAP family.|||extracellular matrix http://togogenome.org/gene/9135:LOC103817037 ^@ http://purl.uniprot.org/uniprot/A0A8C9MPR2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:WNT5B ^@ http://purl.uniprot.org/uniprot/A0A8C9MQJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9135:C8A ^@ http://purl.uniprot.org/uniprot/A0A8C9MTZ3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9135:TOP3B ^@ http://purl.uniprot.org/uniprot/A0A8C9MNL8 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/9135:COG4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MR48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG4 family.|||Golgi apparatus membrane http://togogenome.org/gene/9135:COPS7B ^@ http://purl.uniprot.org/uniprot/A0A8C9NLU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:IFNG ^@ http://purl.uniprot.org/uniprot/A0A8C9MH47 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II (or gamma) interferon family.|||Homodimer.|||Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.|||Secreted http://togogenome.org/gene/9135:SNCA ^@ http://purl.uniprot.org/uniprot/Q91448 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.|||Belongs to the synuclein family.|||Brain.|||May be involved in neuronal plasticity.|||May be involved in the regulation of dopamine release and transport.|||Membrane|||Nucleus|||Secreted|||Synapse|||cytosol http://togogenome.org/gene/9135:LHX8 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1V2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:KIF27 ^@ http://purl.uniprot.org/uniprot/A0A8C9MND6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9135:MTM1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NUG6|||http://purl.uniprot.org/uniprot/A0A8C9NVS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/9135:MLH1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N919 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||Nucleus http://togogenome.org/gene/9135:TLCD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYS9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:SPC25 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQK7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC25 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/9135:CDX1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/9135:ASCC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NTG1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9135:SQLE ^@ http://purl.uniprot.org/uniprot/A0A8C9MXK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the squalene monooxygenase family.|||Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9135:GPX8 ^@ http://purl.uniprot.org/uniprot/A0A8C9N480 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9135:D2HGDH ^@ http://purl.uniprot.org/uniprot/A0A8C9N0K1 ^@ Similarity ^@ Belongs to the FAD-binding oxidoreductase/transferase type 4 family. http://togogenome.org/gene/9135:GPR155 ^@ http://purl.uniprot.org/uniprot/A0A8C9NTB8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:LOC103819095 ^@ http://purl.uniprot.org/uniprot/A0A8C9NTV8 ^@ Similarity ^@ Belongs to the glycosyltransferase 92 family. http://togogenome.org/gene/9135:C1H2orf49 ^@ http://purl.uniprot.org/uniprot/A0A8C9MI59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ashwin family.|||Nucleus http://togogenome.org/gene/9135:SIAH3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGB0 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9135:TARS1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MEB3 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9135:PLP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NT76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9135:FOXN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MWP8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:TSC22D3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NTI1 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9135:UNC5C ^@ http://purl.uniprot.org/uniprot/A0A8C9NN38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/9135:VAMP7 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9135:RPL13 ^@ http://purl.uniprot.org/uniprot/A0A8C9MY20 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/9135:TRAPPC4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRB7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/9135:MFSD9 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9135:GUK1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTZ4 ^@ Similarity ^@ Belongs to the guanylate kinase family. http://togogenome.org/gene/9135:BUD23 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:DNMBP ^@ http://purl.uniprot.org/uniprot/A0A8C9NPY8|||http://purl.uniprot.org/uniprot/A0A8C9NTU9 ^@ Subcellular Location Annotation ^@ Cell junction|||Golgi stack|||Synapse|||cytoskeleton http://togogenome.org/gene/9135:TEC ^@ http://purl.uniprot.org/uniprot/A0A8C9MZZ1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9135:ESD ^@ http://purl.uniprot.org/uniprot/A0A8C9NJL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the esterase D family.|||Cytoplasmic vesicle|||Serine hydrolase involved in the detoxification of formaldehyde. http://togogenome.org/gene/9135:LOC103822978 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRZ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:FBLN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MI57 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the fibulin family.|||Homomultimerizes and interacts with various extracellular matrix components.|||Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9135:FAM13B ^@ http://purl.uniprot.org/uniprot/A0A8C9UE60 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9135:RGR ^@ http://purl.uniprot.org/uniprot/A0A8C9MI02 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:STX17 ^@ http://purl.uniprot.org/uniprot/A0A8C9MY76 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9135:OTULIN ^@ http://purl.uniprot.org/uniprot/A0A8C9MLW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C65 family. Otulin subfamily.|||Cytoplasm http://togogenome.org/gene/9135:TMEM45A ^@ http://purl.uniprot.org/uniprot/A0A8C9NTT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9135:TENT5A ^@ http://purl.uniprot.org/uniprot/A0A8C9MNA1 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9135:LOC103815314 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJZ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:SLC30A4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MPW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9135:TM4SF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9135:LIPT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQ02 ^@ Similarity ^@ Belongs to the LplA family. http://togogenome.org/gene/9135:LOC103827200 ^@ http://purl.uniprot.org/uniprot/A0A8C9NNM6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:KBTBD8 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KBTBD8 family.|||Golgi apparatus|||spindle http://togogenome.org/gene/9135:WNT4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NTS0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9135:DPCD ^@ http://purl.uniprot.org/uniprot/A0A8C9UIG2 ^@ Similarity ^@ Belongs to the DPCD family. http://togogenome.org/gene/9135:SLC6A15 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.|||Membrane http://togogenome.org/gene/9135:TP73 ^@ http://purl.uniprot.org/uniprot/A0A8C9KXF9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Found in a complex with p53/TP53 and CABLES1.|||Nucleus|||Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. http://togogenome.org/gene/9135:RAB18 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2W1 ^@ Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Lipid droplet http://togogenome.org/gene/9135:PDC ^@ http://purl.uniprot.org/uniprot/A0A8C9N852 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9135:FAM228B ^@ http://purl.uniprot.org/uniprot/A0A8C9NKJ1 ^@ Similarity ^@ Belongs to the FAM228 family. http://togogenome.org/gene/9135:RETREG1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RETREG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:TSPAN12 ^@ http://purl.uniprot.org/uniprot/A0A8C9KSV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9135:ITPR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N303 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the InsP3 receptor family.|||Endoplasmic reticulum membrane|||Homotetramer.|||Membrane|||Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.|||The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. http://togogenome.org/gene/9135:PDGFRA ^@ http://purl.uniprot.org/uniprot/A0A8C9N183 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.|||Membrane|||Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.|||Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. http://togogenome.org/gene/9135:AGK ^@ http://purl.uniprot.org/uniprot/A0A8C9UD84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AGK family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9135:DEGS2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UBB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:NPRL3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.|||Belongs to the NPR3 family.|||Lysosome http://togogenome.org/gene/9135:VIPAS39 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1L8 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Endosome|||Late endosome http://togogenome.org/gene/9135:CSF3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N117 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/9135:LOC103826653 ^@ http://purl.uniprot.org/uniprot/A0A8C9L3E3 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9135:RPS6 ^@ http://purl.uniprot.org/uniprot/A0A8C9KSJ7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/9135:PDCL ^@ http://purl.uniprot.org/uniprot/A0A8C9NTY5 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9135:DUT ^@ http://purl.uniprot.org/uniprot/A0A8C9MQ52 ^@ Function|||Similarity ^@ Belongs to the dUTPase family.|||Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/9135:LOC103816715 ^@ http://purl.uniprot.org/uniprot/A0A8C9MU39 ^@ Subcellular Location Annotation ^@ Membrane|||Membrane raft|||Secreted http://togogenome.org/gene/9135:PAPPA ^@ http://purl.uniprot.org/uniprot/A0A8C9MV12 ^@ Caution|||Similarity ^@ Belongs to the peptidase M43B family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:EXOG ^@ http://purl.uniprot.org/uniprot/A0A8C9MVN9 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/9135:COMTD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGS7 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/9135:CPEB4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPI9 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/9135:RPAP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UG47 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the RPAP2 family.|||Nucleus|||Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. http://togogenome.org/gene/9135:PPIL2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.|||Nucleus http://togogenome.org/gene/9135:AMD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KPC0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic AdoMetDC family.|||Binds 1 pyruvoyl group covalently per subunit.|||Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. http://togogenome.org/gene/9135:LOC103819904 ^@ http://purl.uniprot.org/uniprot/A0A8C9U6T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/9135:TTC21B ^@ http://purl.uniprot.org/uniprot/A0A8C9NQ44 ^@ Similarity ^@ Belongs to the TTC21 family. http://togogenome.org/gene/9135:SLC25A22 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9135:GPR65 ^@ http://purl.uniprot.org/uniprot/A0A8C9N3F8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:YKT6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQE0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. http://togogenome.org/gene/9135:DCLRE1A ^@ http://purl.uniprot.org/uniprot/A0A8C9NNB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9135:SCARF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVZ2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:LOC103815885 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8G3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:LOC103820034 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9135:NFS1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDK6 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/9135:KCNE3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NIH3 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9135:NDRG4 ^@ http://purl.uniprot.org/uniprot/A0A8C9UBE5 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/9135:FNIP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N7H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNIP family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9135:LOC103827283 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKX7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9135:LOC103820557 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8U3 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/9135:UVSSA ^@ http://purl.uniprot.org/uniprot/A0A8C9NQ00 ^@ Similarity ^@ Belongs to the UVSSA family. http://togogenome.org/gene/9135:EIF3M ^@ http://purl.uniprot.org/uniprot/A0A8C9UCF4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Belongs to the eIF-3 subunit M family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm http://togogenome.org/gene/9135:LOC103815911 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Endoplasmic reticulum membrane|||Lysosome|||Membrane|||phagosome http://togogenome.org/gene/9135:CD14 ^@ http://purl.uniprot.org/uniprot/A0A8C9N4R5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Golgi apparatus|||Membrane raft|||Secreted http://togogenome.org/gene/9135:LOC103822176 ^@ http://purl.uniprot.org/uniprot/A0A8C9ND40 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/9135:MAP1LC3A ^@ http://purl.uniprot.org/uniprot/A0A8C9MYA5 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9135:MRPL42 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL42 family.|||Mitochondrion http://togogenome.org/gene/9135:C3H6orf58 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LEG1 family.|||Secreted http://togogenome.org/gene/9135:RHAG ^@ http://purl.uniprot.org/uniprot/A0A8C9NJZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9135:LOC103816734 ^@ http://purl.uniprot.org/uniprot/A0A8C9UBJ5 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/9135:ASPN ^@ http://purl.uniprot.org/uniprot/A0A8C9NEB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||extracellular matrix http://togogenome.org/gene/9135:USP7 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAW2 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9135:LOC103813328 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUF9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9135:WTAP ^@ http://purl.uniprot.org/uniprot/A0A8C9NBP6 ^@ Similarity ^@ Belongs to the fl(2)d family. http://togogenome.org/gene/9135:TRAF6 ^@ http://purl.uniprot.org/uniprot/A0A8C9U4W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family. A subfamily.|||Lipid droplet|||Nucleus|||cell cortex http://togogenome.org/gene/9135:UNC50 ^@ http://purl.uniprot.org/uniprot/A0A8C9NSC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-50 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9135:MTERF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIL6 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9135:FAM83G ^@ http://purl.uniprot.org/uniprot/A0A8C9N1U5 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9135:AKAP9 ^@ http://purl.uniprot.org/uniprot/A0A8C9NFT8 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/9135:ALG5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NHR0 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/9135:GALE ^@ http://purl.uniprot.org/uniprot/A0A8C9MUY4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.|||Homodimer. http://togogenome.org/gene/9135:PDGFRL ^@ http://purl.uniprot.org/uniprot/A0A8C9N6L8 ^@ Subunit ^@ Forms a complex composed of PDGFRL, TNK2 and GRB2. http://togogenome.org/gene/9135:RBBP7 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGE6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:PARVB ^@ http://purl.uniprot.org/uniprot/A0A8C9N0H3 ^@ Similarity ^@ Belongs to the parvin family. http://togogenome.org/gene/9135:NXT2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NTN0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/9135:NDC80 ^@ http://purl.uniprot.org/uniprot/A0A8C9N3U7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NDC80/HEC1 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/9135:TMEM229B ^@ http://purl.uniprot.org/uniprot/A0A8C9UFK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM229 family.|||Membrane http://togogenome.org/gene/9135:GNAL ^@ http://purl.uniprot.org/uniprot/A0A8C9MYB8|||http://purl.uniprot.org/uniprot/A0A8C9N0P7 ^@ Similarity ^@ Belongs to the G-alpha family. G(s) subfamily. http://togogenome.org/gene/9135:NMNAT3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2J8 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9135:LOC103826887 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYA2 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9135:NUP155 ^@ http://purl.uniprot.org/uniprot/A0A8C9N023 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the non-repetitive/WGA-negative nucleoporin family.|||nuclear pore complex http://togogenome.org/gene/9135:ELP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UE46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP1/IKA1 family.|||Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:PRCP ^@ http://purl.uniprot.org/uniprot/A0A8C9MHQ6 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/9135:MESD ^@ http://purl.uniprot.org/uniprot/A0A8C9MQX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MESD family.|||Endoplasmic reticulum http://togogenome.org/gene/9135:PDE7A ^@ http://purl.uniprot.org/uniprot/A0A8C9NKC6 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9135:LOC103814999 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIM0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9135:ATPAF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N3P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP12 family.|||Mitochondrion http://togogenome.org/gene/9135:LOC103822562 ^@ http://purl.uniprot.org/uniprot/A0A8C9NNQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/9135:ATP13A4 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Membrane http://togogenome.org/gene/9135:TMEM269 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJ73 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/9135:MRPL58 ^@ http://purl.uniprot.org/uniprot/A0A8C9KTT7 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9135:LOC103813356 ^@ http://purl.uniprot.org/uniprot/A0A8C9MU99 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9135:TBPL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NC34 ^@ Similarity ^@ Belongs to the TBP family. http://togogenome.org/gene/9135:WASHC3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N6U8 ^@ Similarity ^@ Belongs to the CCDC53 family. http://togogenome.org/gene/9135:BCAT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MXI4 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9135:TM4SF4 ^@ http://purl.uniprot.org/uniprot/A0A8C9N252 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9135:CROT ^@ http://purl.uniprot.org/uniprot/A0A8C9NBL8 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9135:DPT ^@ http://purl.uniprot.org/uniprot/A0A8C9N399 ^@ Similarity ^@ Belongs to the dermatopontin family. http://togogenome.org/gene/9135:NADK ^@ http://purl.uniprot.org/uniprot/A0A8C9NYH2|||http://purl.uniprot.org/uniprot/A0A8C9NZ05 ^@ Similarity ^@ Belongs to the NAD kinase family. http://togogenome.org/gene/9135:VDAC2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGS2 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/9135:RNASEH2B ^@ http://purl.uniprot.org/uniprot/A0A8C9NF77 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase H2 subunit B family.|||Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|||Nucleus|||The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C. http://togogenome.org/gene/9135:AQP9 ^@ http://purl.uniprot.org/uniprot/A0A8C9KPV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9135:DUSP7 ^@ http://purl.uniprot.org/uniprot/A0A8C9NWB9 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9135:LOC103824282 ^@ http://purl.uniprot.org/uniprot/A0A8C9NXV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-5A synthase family.|||Cytoplasm http://togogenome.org/gene/9135:TEAD4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQN9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:COMT ^@ http://purl.uniprot.org/uniprot/A0A8C9MMT8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. http://togogenome.org/gene/9135:UBE2T ^@ http://purl.uniprot.org/uniprot/A0A8C9MWW4 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9135:TMEM192 ^@ http://purl.uniprot.org/uniprot/A0A8C9N6B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM192 family.|||Late endosome|||Lysosome membrane|||Membrane http://togogenome.org/gene/9135:LOC103823445 ^@ http://purl.uniprot.org/uniprot/A0A8C9U8R9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Homodimer.|||Secreted http://togogenome.org/gene/9135:TNFRSF11B ^@ http://purl.uniprot.org/uniprot/A0A8C9MW24 ^@ Caution|||Function|||Subunit ^@ Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:JPH3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MW11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/9135:FOXM1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UH09 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:TIMM13 ^@ http://purl.uniprot.org/uniprot/A0A8C9L366 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9135:SMPX ^@ http://purl.uniprot.org/uniprot/A0A8C9NLF6 ^@ Function|||Similarity ^@ Belongs to the SMPX family.|||Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. http://togogenome.org/gene/9135:GPN3 ^@ http://purl.uniprot.org/uniprot/A0A8C9UD31 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.|||Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/9135:LAMA2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJ65 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9135:ATG13 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG13 family. Metazoan subfamily.|||Preautophagosomal structure http://togogenome.org/gene/9135:TRADD ^@ http://purl.uniprot.org/uniprot/A0A8C9MP40 ^@ Subcellular Location Annotation ^@ Nucleus|||cytoskeleton http://togogenome.org/gene/9135:CFH ^@ http://purl.uniprot.org/uniprot/A0A8C9NA63 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:SMG5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NH53 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays a role in nonsense-mediated mRNA decay. http://togogenome.org/gene/9135:ENY2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UB64 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2). Component of the SAGA transcription coactivator-HAT complex. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.|||nucleoplasm http://togogenome.org/gene/9135:KRR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N0L5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KRR1 family.|||Component of the ribosomal small subunit (SSU) processome.|||Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.|||nucleolus http://togogenome.org/gene/9135:KDELR3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMQ8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:GAL ^@ http://purl.uniprot.org/uniprot/A0A8C9MKC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the galanin family.|||Secreted http://togogenome.org/gene/9135:PSMD5 ^@ http://purl.uniprot.org/uniprot/A0A8C9L4D0 ^@ Similarity ^@ Belongs to the proteasome subunit S5B/HSM3 family. http://togogenome.org/gene/9135:DNAJA2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLZ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:ZC3H12C ^@ http://purl.uniprot.org/uniprot/A0A8C9MNT9 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/9135:PRMT7 ^@ http://purl.uniprot.org/uniprot/A0A8C9U7U3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.|||Nucleus|||cytosol http://togogenome.org/gene/9135:SLC27A4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MT11 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9135:MIEF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1Z5 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9135:MRPS33 ^@ http://purl.uniprot.org/uniprot/A0A8C9N698 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS33 family.|||Mitochondrion http://togogenome.org/gene/9135:LOC103820493 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVW0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:KCNC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQ03 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:PLAU ^@ http://purl.uniprot.org/uniprot/A0A8C9MGI3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:UPP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MNB5 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. http://togogenome.org/gene/9135:CCND2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2L6 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9135:MAGT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NUI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:PTPRB ^@ http://purl.uniprot.org/uniprot/A0A8C9N3S2 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. http://togogenome.org/gene/9135:CLN8 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDB0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:TMEM43 ^@ http://purl.uniprot.org/uniprot/A0A8C9MPA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM43 family.|||Membrane http://togogenome.org/gene/9135:SLCO2A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9U942 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:LTV1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NNM7 ^@ Similarity ^@ Belongs to the LTV1 family. http://togogenome.org/gene/9135:CHRNA4 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9135:AOX1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGW2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/9135:GOT2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UA67 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/9135:IRF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N7R6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Nucleus http://togogenome.org/gene/9135:LOC103813306 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGG3 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9135:ITPKA ^@ http://purl.uniprot.org/uniprot/A0A8C9MFZ9 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9135:DRGX ^@ http://purl.uniprot.org/uniprot/A0A8C9NTG8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:LOC103814477 ^@ http://purl.uniprot.org/uniprot/A0A8C9KYB5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9135:LOC103824319 ^@ http://purl.uniprot.org/uniprot/A0A8C9KWD1 ^@ Similarity ^@ Belongs to the ADP-ribosyl cyclase family. http://togogenome.org/gene/9135:PTP4A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UCZ1 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9135:SLC7A6 ^@ http://purl.uniprot.org/uniprot/A0A8C9MNZ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:P2RX1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MR72 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9135:KDM5B ^@ http://purl.uniprot.org/uniprot/A0A8C9MUJ3 ^@ Similarity ^@ Belongs to the JARID1 histone demethylase family. http://togogenome.org/gene/9135:DDR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NYB2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:FAM114A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MPM5 ^@ Similarity ^@ Belongs to the FAM114 family. http://togogenome.org/gene/9135:ACVR1B ^@ http://purl.uniprot.org/uniprot/A0A8C9UBP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9135:UCHL5 ^@ http://purl.uniprot.org/uniprot/A0A8C9UEC7 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/9135:TPK1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQV7|||http://purl.uniprot.org/uniprot/A0A8C9NT10 ^@ Similarity ^@ Belongs to the thiamine pyrophosphokinase family. http://togogenome.org/gene/9135:SF3B6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKI0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:DES ^@ http://purl.uniprot.org/uniprot/A0A8C9NKN5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9135:ST14 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRU0|||http://purl.uniprot.org/uniprot/A0A8C9UIG1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:LZIC ^@ http://purl.uniprot.org/uniprot/A0A8C9NVW6 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/9135:NEU2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIK9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/9135:PDPK1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHQ5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. http://togogenome.org/gene/9135:LIN7C ^@ http://purl.uniprot.org/uniprot/A0A8C9MY93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-7 family.|||Cell junction|||Cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. http://togogenome.org/gene/9135:ITK ^@ http://purl.uniprot.org/uniprot/A0A8C9NI55 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9135:PARK7 ^@ http://purl.uniprot.org/uniprot/A0A8C9MH38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C56 family.|||Membrane raft http://togogenome.org/gene/9135:ACSF3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MXI8 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9135:SLC26A3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.|||Membrane http://togogenome.org/gene/9135:SEMA3E ^@ http://purl.uniprot.org/uniprot/A0A8C9N209 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:GGT7 ^@ http://purl.uniprot.org/uniprot/A0A8C9N9P2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyltransferase family.|||Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.|||Membrane http://togogenome.org/gene/9135:ZDHHC3 ^@ http://purl.uniprot.org/uniprot/A0A8C9U118 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9135:LOC103812985 ^@ http://purl.uniprot.org/uniprot/A0A8C9L6H6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:TPPP ^@ http://purl.uniprot.org/uniprot/A0A8C9NP73 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/9135:LOC103822065 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/9135:TNFRSF1B ^@ http://purl.uniprot.org/uniprot/A0A8C9MHV5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:TRMU ^@ http://purl.uniprot.org/uniprot/A0A8C9MP96 ^@ Function|||Similarity ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. http://togogenome.org/gene/9135:PICK1 ^@ http://purl.uniprot.org/uniprot/A0A8C9U6E0 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.|||cytoskeleton|||perinuclear region|||synaptosome http://togogenome.org/gene/9135:DDX55 ^@ http://purl.uniprot.org/uniprot/A0A8C9N707 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9135:NRN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KTN1 ^@ Similarity ^@ Belongs to the neuritin family. http://togogenome.org/gene/9135:IDH3A ^@ http://purl.uniprot.org/uniprot/A0A8C9UFN5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/9135:RTCB ^@ http://purl.uniprot.org/uniprot/A0A8C9MKG1 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Catalytic component of the tRNA-splicing ligase complex.|||Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.|||Cytoplasm|||Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP. http://togogenome.org/gene/9135:WARS1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MXH7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9135:ADORA2A ^@ http://purl.uniprot.org/uniprot/A0A8C9MJH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/9135:DNASE2B ^@ http://purl.uniprot.org/uniprot/A0A8C9NM41 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/9135:DDX59 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAZ8 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX59 subfamily. http://togogenome.org/gene/9135:NDE1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N9S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudE family.|||centrosome|||spindle http://togogenome.org/gene/9135:CDH12 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLM1 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/9135:ACER1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGL3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Membrane http://togogenome.org/gene/9135:SLC27A6 ^@ http://purl.uniprot.org/uniprot/A0A8C9UFU7 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9135:LOC103820148 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8A2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:PSMD4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTT3 ^@ Similarity ^@ Belongs to the proteasome subunit S5A family. http://togogenome.org/gene/9135:MAP2K3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N4G1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:LOC103815242 ^@ http://purl.uniprot.org/uniprot/A0A8C9N0X8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9135:SPARC ^@ http://purl.uniprot.org/uniprot/A0A8C9NFC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.|||Belongs to the SPARC family.|||Membrane|||basement membrane http://togogenome.org/gene/9135:SPIN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NIV9 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/9135:ENPP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UAV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.|||Secreted http://togogenome.org/gene/9135:STEAP3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9135:MED27 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 27 family.|||Nucleus http://togogenome.org/gene/9135:MYRF ^@ http://purl.uniprot.org/uniprot/A0A8C9N874 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRF family.|||Membrane http://togogenome.org/gene/9135:PATJ ^@ http://purl.uniprot.org/uniprot/A0A8C9UAF8 ^@ Subcellular Location Annotation ^@ tight junction http://togogenome.org/gene/9135:LOC108964905 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFL9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9135:PISD ^@ http://purl.uniprot.org/uniprot/A0A8C9MK04 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.|||Mitochondrion inner membrane http://togogenome.org/gene/9135:EHD3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQT3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9135:TFIP11 ^@ http://purl.uniprot.org/uniprot/A0A8C9MR67 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFP11/STIP family.|||Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events.|||Nucleus http://togogenome.org/gene/9135:SLC4A11 ^@ http://purl.uniprot.org/uniprot/A0A8C9N5L1|||http://purl.uniprot.org/uniprot/A0A8C9N6J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:LOC103816903 ^@ http://purl.uniprot.org/uniprot/A0A8C9N257 ^@ Similarity|||Subunit ^@ Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.|||Homotetramer. http://togogenome.org/gene/9135:PKD2L1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NW62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polycystin family.|||Membrane|||cilium membrane http://togogenome.org/gene/9135:CPT2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MSR8 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9135:LOC103814353 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9135:GGT5 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyltransferase family.|||Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.|||Membrane http://togogenome.org/gene/9135:LOC103821672 ^@ http://purl.uniprot.org/uniprot/A0A8C9UDU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/9135:SETD6 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.|||Nucleus|||Protein-lysine N-methyltransferase. http://togogenome.org/gene/9135:CCL20 ^@ http://purl.uniprot.org/uniprot/A0A8C9MED3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9135:IL1RAPL2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NXW0 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9135:TPR ^@ http://purl.uniprot.org/uniprot/A0A8C9N537 ^@ Similarity ^@ Belongs to the TPR family. http://togogenome.org/gene/9135:NTS ^@ http://purl.uniprot.org/uniprot/A0A8C9MZF5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurotensin family.|||Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/9135:N6AMT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NBV0 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/9135:PRKCE ^@ http://purl.uniprot.org/uniprot/A0A8C9N972 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/9135:LOC103814190 ^@ http://purl.uniprot.org/uniprot/A0A8C9NXP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/9135:SLC41A3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MNJ9|||http://purl.uniprot.org/uniprot/A0A8C9U7F5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/9135:METTL4 ^@ http://purl.uniprot.org/uniprot/A0A8C9N3G2 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/9135:TRMT11 ^@ http://purl.uniprot.org/uniprot/A0A8C9NN67 ^@ Function ^@ Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs. http://togogenome.org/gene/9135:PRKACB ^@ http://purl.uniprot.org/uniprot/A0A8C9UGV3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/9135:HOXA9 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/9135:LDAH ^@ http://purl.uniprot.org/uniprot/A0A8C9NIL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. LDAH family.|||Lipid droplet http://togogenome.org/gene/9135:PDLIM3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N6T9 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/9135:GABRA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N5U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9135:LOC103826740 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMI8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:CENPN ^@ http://purl.uniprot.org/uniprot/A0A8C9MTJ7 ^@ Similarity ^@ Belongs to the CENP-N/CHL4 family. http://togogenome.org/gene/9135:EMSY ^@ http://purl.uniprot.org/uniprot/A0A8C9NPH3|||http://purl.uniprot.org/uniprot/A0A8C9UHZ5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:MFSD10 ^@ http://purl.uniprot.org/uniprot/A0A8C9UH67 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:LAPTM4B ^@ http://purl.uniprot.org/uniprot/A0A8C9ML88 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/9135:CLP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N6Q8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Clp1 family. Clp1 subfamily.|||Component of the tRNA splicing endonuclease complex. Component of pre-mRNA cleavage complex II (CF-II).|||Nucleus|||Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing. http://togogenome.org/gene/9135:TUBGCP3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMY4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/9135:SLC2A12 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAS5 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/9135:MCM6 ^@ http://purl.uniprot.org/uniprot/A0A8C9N4A4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9135:CHPT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N550 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/9135:GSN ^@ http://purl.uniprot.org/uniprot/A0A8C9KVY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the villin/gelsolin family.|||Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.|||cytoskeleton http://togogenome.org/gene/9135:LOC103816300 ^@ http://purl.uniprot.org/uniprot/A0A8C9NU53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Membrane http://togogenome.org/gene/9135:LOC103820494 ^@ http://purl.uniprot.org/uniprot/A0A8C9MXD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:RPL24 ^@ http://purl.uniprot.org/uniprot/A0A8C9NV69 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/9135:ABCC9 ^@ http://purl.uniprot.org/uniprot/A0A8C9N030|||http://purl.uniprot.org/uniprot/A0A8C9N2U6 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with KCNJ11.|||Membrane http://togogenome.org/gene/9135:SYT14 ^@ http://purl.uniprot.org/uniprot/A0A8C9MU10 ^@ Similarity ^@ Belongs to the synaptotagmin family. http://togogenome.org/gene/9135:HGF ^@ http://purl.uniprot.org/uniprot/A0A8C9N0E3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. http://togogenome.org/gene/9135:RAD50 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8N3 ^@ Similarity ^@ Belongs to the SMC family. RAD50 subfamily. http://togogenome.org/gene/9135:EMC3 ^@ http://purl.uniprot.org/uniprot/A0A8C9L4M7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC3 family.|||Component of the ER membrane protein complex (EMC).|||Membrane http://togogenome.org/gene/9135:HAUS8 ^@ http://purl.uniprot.org/uniprot/A0A8C9MK66 ^@ Similarity ^@ Belongs to the QWRF family. http://togogenome.org/gene/9135:PARD6B ^@ http://purl.uniprot.org/uniprot/A0A8C9NSH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/9135:PFKP ^@ http://purl.uniprot.org/uniprot/A0A8C9MZV1|||http://purl.uniprot.org/uniprot/A0A8C9N1C6|||http://purl.uniprot.org/uniprot/A0A8C9N259 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homo- and heterotetramers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:PPARD ^@ http://purl.uniprot.org/uniprot/A0A8C9NRA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9135:AASDH ^@ http://purl.uniprot.org/uniprot/A0A8C9N0X1 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9135:LOC103814641 ^@ http://purl.uniprot.org/uniprot/A0A8C9NA11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Cell membrane|||Membrane|||Membrane raft|||Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. http://togogenome.org/gene/9135:LOC103816843 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRF5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9135:DCK ^@ http://purl.uniprot.org/uniprot/A0A8C9MLK4 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/9135:LOC103813346 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUU4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9135:BMS1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHK3 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9135:PAX2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NWN2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:LOC103824250 ^@ http://purl.uniprot.org/uniprot/A0A8C9NUE8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9135:LOC103822554 ^@ http://purl.uniprot.org/uniprot/A0A8C9NL53 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:MSTN ^@ http://purl.uniprot.org/uniprot/A0A8C9MK78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Secreted http://togogenome.org/gene/9135:SLC25A44 ^@ http://purl.uniprot.org/uniprot/A0A8C9NH77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9135:PIK3R1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCI8|||http://purl.uniprot.org/uniprot/A0A8C9UEG6 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/9135:SLC45A4 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1F7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:LOC103823758 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/9135:RHPN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KSW8 ^@ Similarity ^@ Belongs to the RHPN family. http://togogenome.org/gene/9135:TRAM1 ^@ http://purl.uniprot.org/uniprot/A0A8C9L6F2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/9135:LOC103824466 ^@ http://purl.uniprot.org/uniprot/A0A8C9UC84 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9135:LOC103827070 ^@ http://purl.uniprot.org/uniprot/A0A8C9N3V5 ^@ Similarity ^@ Belongs to the intercrine gamma family. http://togogenome.org/gene/9135:NPM3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPB0 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/9135:FOXN4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTF2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:FAM3B ^@ http://purl.uniprot.org/uniprot/A0A8C9NBY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9135:CDK8 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVF0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:FAM110B ^@ http://purl.uniprot.org/uniprot/A0A8C9NET9 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/9135:METTL6 ^@ http://purl.uniprot.org/uniprot/A0A8C9L325 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9135:CFAP298 ^@ http://purl.uniprot.org/uniprot/A0A8C9UD45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP298 family.|||cilium basal body http://togogenome.org/gene/9135:CALHM3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NVW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9135:ELP6 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQJ0 ^@ Similarity ^@ Belongs to the ELP6 family. http://togogenome.org/gene/9135:RPRD1A ^@ http://purl.uniprot.org/uniprot/A0A8C9MQX2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.|||Nucleus http://togogenome.org/gene/9135:RER1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MDM8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RER1 family.|||Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.|||Membrane http://togogenome.org/gene/9135:LOC103817534 ^@ http://purl.uniprot.org/uniprot/A0A8C9L4J5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:ABCA5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NER7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:TNFAIP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NH79 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/9135:RUVBL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||Dynein axonemal particle|||Nucleus|||Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. http://togogenome.org/gene/9135:RARS2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIU7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9135:ZDHHC22 ^@ http://purl.uniprot.org/uniprot/A0A8C9N6E3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9135:HOXD12 ^@ http://purl.uniprot.org/uniprot/A0A8C9UI48 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:MYOZ3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NF01 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9135:PPARA ^@ http://purl.uniprot.org/uniprot/A0A8C9MHX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9135:PRLR ^@ http://purl.uniprot.org/uniprot/A0A8C9MYG5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Membrane|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation.|||This is a receptor for the anterior pituitary hormone prolactin. http://togogenome.org/gene/9135:LITAFD ^@ http://purl.uniprot.org/uniprot/A0A8C9UEN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/9135:LOC103820323 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKN5 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/9135:EPHB6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NR02 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:DYNC1I2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NU33 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/9135:LOC103821417 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFY9 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/9135:LOC103815251 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFM7 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9135:PRR5L ^@ http://purl.uniprot.org/uniprot/A0A8C9MJY5 ^@ Similarity ^@ Belongs to the PROTOR family. http://togogenome.org/gene/9135:B3GNT7 ^@ http://purl.uniprot.org/uniprot/A0A8C9NP56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9135:UGGT2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UI10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 8 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9135:SVBP ^@ http://purl.uniprot.org/uniprot/A0A8C9MIV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVBP family.|||Secreted|||cytoskeleton http://togogenome.org/gene/9135:TSPAN6 ^@ http://purl.uniprot.org/uniprot/A0A8C9U4B5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9135:ADCYAP1R1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTE5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:LOC103813813 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLJ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 6c family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9135:TBX15 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAT9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9135:SETD3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MX19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.|||Cytoplasm http://togogenome.org/gene/9135:PLD4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTY8 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9135:CEP43 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP43 family.|||cilium basal body http://togogenome.org/gene/9135:C1D ^@ http://purl.uniprot.org/uniprot/A0A8C9L3W2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the C1D family.|||Cytoplasm|||Monomer and homodimer.|||Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.|||nucleolus http://togogenome.org/gene/9135:LOC103815347 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJD4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9135:LOC103813629 ^@ http://purl.uniprot.org/uniprot/A0A8C9UBC1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9135:CA9 ^@ http://purl.uniprot.org/uniprot/A0A8C9MF95 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9135:ADGRL4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NLX4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:TRIO ^@ http://purl.uniprot.org/uniprot/A0A8C9MLR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Cytoplasm http://togogenome.org/gene/9135:PTDSS2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UCS2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphatidyl serine synthase family.|||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:UTS2B ^@ http://purl.uniprot.org/uniprot/A0A8C9NQK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urotensin-2 family.|||Secreted http://togogenome.org/gene/9135:RALY ^@ http://purl.uniprot.org/uniprot/A0A8C9UC59 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/9135:HMGB2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N4K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/9135:TERF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9L6N9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.|||Homodimer.|||Nucleus http://togogenome.org/gene/9135:SNX4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NB84 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9135:ACOD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRT5 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/9135:SLU7 ^@ http://purl.uniprot.org/uniprot/A0A8C9N7L5|||http://purl.uniprot.org/uniprot/A0A8C9N9P3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SLU7 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/9135:LOC103827166 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9135:CHDH ^@ http://purl.uniprot.org/uniprot/A0A8C9MFJ5 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/9135:FHIP2A ^@ http://purl.uniprot.org/uniprot/A0A8C9UGU4 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/9135:IGBP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KVG0 ^@ Similarity ^@ Belongs to the IGBP1/TAP42 family. http://togogenome.org/gene/9135:SGCD ^@ http://purl.uniprot.org/uniprot/A0A8C9NF48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9135:PPM1A ^@ http://purl.uniprot.org/uniprot/A0A8C9MQF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/9135:GNG2 ^@ http://purl.uniprot.org/uniprot/A0A8C9KXW5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9135:CRYZ ^@ http://purl.uniprot.org/uniprot/A0A8C9N159 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9135:TPM1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NTQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9135:CLSTN3 ^@ http://purl.uniprot.org/uniprot/A0A8C9UH98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calsyntenin family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Postsynaptic cell membrane http://togogenome.org/gene/9135:DDIAS ^@ http://purl.uniprot.org/uniprot/A0A8C9MHJ1 ^@ Similarity ^@ Belongs to the replication factor A protein 1 family. http://togogenome.org/gene/9135:FGF14 ^@ http://purl.uniprot.org/uniprot/A0A8C9NV22 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9135:CD81 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9135:RPL3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MPA1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/9135:KIF20A ^@ http://purl.uniprot.org/uniprot/A0A8C9MEP9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9135:ATG4C ^@ http://purl.uniprot.org/uniprot/A0A8C9MU55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/9135:SEC11C ^@ http://purl.uniprot.org/uniprot/A0A8C9MHX9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:MAP4K3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NNZ9|||http://purl.uniprot.org/uniprot/A0A8C9NQW4 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. http://togogenome.org/gene/9135:RPS12 ^@ http://purl.uniprot.org/uniprot/A0A8C9UE30 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family. http://togogenome.org/gene/9135:POT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the telombin family.|||Nucleus|||telomere http://togogenome.org/gene/9135:CWC15 ^@ http://purl.uniprot.org/uniprot/A0A8C9MK60 ^@ Similarity ^@ Belongs to the CWC15 family. http://togogenome.org/gene/9135:MEOX2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJG6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:PCBP4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NXY6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9135:CHMP4B ^@ http://purl.uniprot.org/uniprot/A0A8C9MYR0 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9135:HPGD ^@ http://purl.uniprot.org/uniprot/A0A8C9UDJ0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9135:ATRX ^@ http://purl.uniprot.org/uniprot/A0A8C9NUN0 ^@ Subcellular Location Annotation ^@ Nucleus|||telomere http://togogenome.org/gene/9135:MYD88 ^@ http://purl.uniprot.org/uniprot/A0A8C9MV60 ^@ Function|||Subcellular Location Annotation ^@ Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.|||Cytoplasm http://togogenome.org/gene/9135:ITIH2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N603 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9135:ELAVL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KVV2|||http://purl.uniprot.org/uniprot/A0A8C9L201 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm http://togogenome.org/gene/9135:PLIN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UA46 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9135:PDK1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9135:LOC103813914 ^@ http://purl.uniprot.org/uniprot/A0A8C9UI51 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9135:RPL35A ^@ http://purl.uniprot.org/uniprot/A0A8C9NNS1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/9135:TBC1D23 ^@ http://purl.uniprot.org/uniprot/A0A8C9NTQ0 ^@ Subcellular Location Annotation ^@ trans-Golgi network http://togogenome.org/gene/9135:LCLAT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UH43 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9135:OTX2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9135:LOC103815509 ^@ http://purl.uniprot.org/uniprot/A0A8C9UCG8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.|||Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:TMEM208 ^@ http://purl.uniprot.org/uniprot/A0A8C9U9B9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM208 family.|||Endoplasmic reticulum membrane|||May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.|||Membrane http://togogenome.org/gene/9135:ENTPD6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NLV0 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9135:ABCB11 ^@ http://purl.uniprot.org/uniprot/A0A8C9NT72 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:PPFIA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYN4 ^@ Similarity ^@ Belongs to the liprin family. Liprin-alpha subfamily. http://togogenome.org/gene/9135:TSC22D1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NLF9 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9135:STYXL2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NFP7 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9135:GGH ^@ http://purl.uniprot.org/uniprot/A0A8C9NKA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C26 family.|||extracellular space http://togogenome.org/gene/9135:MAPK6 ^@ http://purl.uniprot.org/uniprot/A0A8C9MNN5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9135:TIPRL ^@ http://purl.uniprot.org/uniprot/A0A8C9N2P4 ^@ Similarity ^@ Belongs to the TIP41 family. http://togogenome.org/gene/9135:ECHDC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NLM1 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9135:WAPL ^@ http://purl.uniprot.org/uniprot/A0A8C9MJC2|||http://purl.uniprot.org/uniprot/A0A8C9MJQ5 ^@ Similarity ^@ Belongs to the WAPL family. http://togogenome.org/gene/9135:TUBE1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPT9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||cytoskeleton http://togogenome.org/gene/9135:MEF2C ^@ http://purl.uniprot.org/uniprot/A0A8C9UC42 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:TIE1 ^@ http://purl.uniprot.org/uniprot/A0A8C9L222 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:LOC103817691 ^@ http://purl.uniprot.org/uniprot/A0A8C9N9R6 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9135:CREBL2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N953 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. ATF subfamily.|||Nucleus http://togogenome.org/gene/9135:FAM83A ^@ http://purl.uniprot.org/uniprot/A0A8C9MVG6 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9135:GPBP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/9135:ENAH ^@ http://purl.uniprot.org/uniprot/A0A8C9NK56|||http://purl.uniprot.org/uniprot/A0A8C9NP52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ena/VASP family.|||cytoskeleton http://togogenome.org/gene/9135:AARS1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MSB6 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Monomer. Interacts with ANKRD16; the interaction is direct. http://togogenome.org/gene/9135:LOC103826392 ^@ http://purl.uniprot.org/uniprot/A0A8C9KTU8 ^@ Function ^@ Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. http://togogenome.org/gene/9135:DGLUCY ^@ http://purl.uniprot.org/uniprot/A0A8C9N0Y5 ^@ Similarity ^@ Belongs to the D-glutamate cyclase family. http://togogenome.org/gene/9135:PPM1G ^@ http://purl.uniprot.org/uniprot/A0A8C9NJH8 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9135:ITGB6 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:SERPINH1 ^@ http://purl.uniprot.org/uniprot/A0A8C9L0M9 ^@ Function|||Similarity ^@ Belongs to the serpin family.|||Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. http://togogenome.org/gene/9135:NDUFA5 ^@ http://purl.uniprot.org/uniprot/A0A8C9U6K3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9135:RAB33A ^@ http://purl.uniprot.org/uniprot/A0A8C9NRS0 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/9135:PTCD3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NN64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS39 family.|||Mitochondrion http://togogenome.org/gene/9135:RIPOR3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRK7 ^@ Similarity ^@ Belongs to the RIPOR family. http://togogenome.org/gene/9135:MFF ^@ http://purl.uniprot.org/uniprot/A0A8C9KSM7|||http://purl.uniprot.org/uniprot/A0A8C9KX45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tango11 family.|||Membrane|||Mitochondrion outer membrane|||Peroxisome|||Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. http://togogenome.org/gene/9135:PRKD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDH3|||http://purl.uniprot.org/uniprot/A0A8C9UED1 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by DAG and phorbol esters.|||Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9135:PALMD ^@ http://purl.uniprot.org/uniprot/A0A8C9NDB5 ^@ Similarity ^@ Belongs to the paralemmin family. http://togogenome.org/gene/9135:FHIP1A ^@ http://purl.uniprot.org/uniprot/A0A8C9NEL7 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/9135:NR2F2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N036 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9135:EREG ^@ http://purl.uniprot.org/uniprot/A0A8C9U8Q9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:SFRP5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NTK1 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:FAM98A ^@ http://purl.uniprot.org/uniprot/A0A8C9NA60 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/9135:LOC108962703 ^@ http://purl.uniprot.org/uniprot/A0A8C9UAC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9135:LOC103821612 ^@ http://purl.uniprot.org/uniprot/A0A8C9UCB3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9135:SKI ^@ http://purl.uniprot.org/uniprot/A0A8C9L4Q5 ^@ Similarity ^@ Belongs to the SKI family. http://togogenome.org/gene/9135:PKIB ^@ http://purl.uniprot.org/uniprot/A0A8C9NJE4 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9135:LNPK ^@ http://purl.uniprot.org/uniprot/A0A8C9NUE2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lunapark family.|||Endoplasmic reticulum membrane|||Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.|||Plays a role in determining ER morphology.|||The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation. http://togogenome.org/gene/9135:LOC103815947 ^@ http://purl.uniprot.org/uniprot/A0A8C9NVN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DUOXA family.|||Membrane http://togogenome.org/gene/9135:EIF4A2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJI5 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9135:BTBD10 ^@ http://purl.uniprot.org/uniprot/A0A8C9NY07 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9135:LOC103814509 ^@ http://purl.uniprot.org/uniprot/A0A8C9U3X9 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9135:CAMLG ^@ http://purl.uniprot.org/uniprot/A0A8C9N7Q8 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells. http://togogenome.org/gene/9135:PGM5 ^@ http://purl.uniprot.org/uniprot/A0A8C9U684 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9135:ADRB2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MF16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Golgi apparatus|||Membrane http://togogenome.org/gene/9135:SEC24C ^@ http://purl.uniprot.org/uniprot/A0A8C9L3U8|||http://purl.uniprot.org/uniprot/A0A8C9MEP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9135:RTN4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJQ8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:WSCD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NH73 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WSCD family.|||Golgi apparatus membrane|||Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. http://togogenome.org/gene/9135:LOC103816970 ^@ http://purl.uniprot.org/uniprot/A0A8C9KRJ6|||http://purl.uniprot.org/uniprot/A0A8C9KRL6|||http://purl.uniprot.org/uniprot/A0A8C9KS97 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9135:SLC25A36 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9135:ARF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9135:TMEM234 ^@ http://purl.uniprot.org/uniprot/A0A8C9MNH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM234 family.|||Membrane http://togogenome.org/gene/9135:DBT ^@ http://purl.uniprot.org/uniprot/A0A8C9ND05|||http://purl.uniprot.org/uniprot/A0A8C9NGR5 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/9135:CCR10 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVD7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:G6PC2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UHT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9135:FAR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1H1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acyl-CoA reductase family.|||Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.|||Peroxisome membrane http://togogenome.org/gene/9135:UNC13B ^@ http://purl.uniprot.org/uniprot/A0A8C9MI51 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9135:RHBG ^@ http://purl.uniprot.org/uniprot/A0A8C9NNK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9135:C3H6orf120 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0669 family.|||Secreted http://togogenome.org/gene/9135:CCT5 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9135:NR5A2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/9135:BEND6 ^@ http://purl.uniprot.org/uniprot/A0A8C9N304|||http://purl.uniprot.org/uniprot/A0A8C9UD39 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:WNT5A ^@ http://purl.uniprot.org/uniprot/A0A8C9MFT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9135:APOLD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MV63 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/9135:CDC5L ^@ http://purl.uniprot.org/uniprot/A0A8C9NMX3 ^@ Similarity ^@ Belongs to the CEF1 family. http://togogenome.org/gene/9135:GJC2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MT24 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9135:DERL2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRY7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/9135:HAPLN3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MS27 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:RNF121 ^@ http://purl.uniprot.org/uniprot/A0A8C9UII7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:SEC16B ^@ http://purl.uniprot.org/uniprot/A0A8C9N5G5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC16 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.|||SEC16A and SEC16B are each present in multiple copies in a heteromeric complex. http://togogenome.org/gene/9135:PUS10 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMU9 ^@ Similarity ^@ Belongs to the pseudouridine synthase Pus10 family. http://togogenome.org/gene/9135:MOGAT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9135:LYN ^@ http://purl.uniprot.org/uniprot/A0A8C9NIC3|||http://purl.uniprot.org/uniprot/A0A8C9UFD3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9135:BICD2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N7H8|||http://purl.uniprot.org/uniprot/A0A8C9NA65 ^@ Similarity ^@ Belongs to the BicD family. http://togogenome.org/gene/9135:LOC103813332 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUQ2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9135:ADCYAP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N628 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/9135:LUC7L2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MSF7 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9135:MELK ^@ http://purl.uniprot.org/uniprot/A0A8C9UDI9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/9135:VBP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NWQ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/9135:DYNLT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJ88 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9135:GPATCH1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UF73 ^@ Similarity ^@ Belongs to the GPATCH1 family. http://togogenome.org/gene/9135:TEKT4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||flagellum http://togogenome.org/gene/9135:RPL36 ^@ http://purl.uniprot.org/uniprot/A0A8C9KVF9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/9135:MVD ^@ http://purl.uniprot.org/uniprot/A0A8C9MVG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diphosphomevalonate decarboxylase family.|||Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.|||Nucleus http://togogenome.org/gene/9135:PNN ^@ http://purl.uniprot.org/uniprot/A0A8C9N811 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pinin family.|||Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.|||Nucleus speckle|||desmosome http://togogenome.org/gene/9135:SVIL ^@ http://purl.uniprot.org/uniprot/A0A8C9N1X6|||http://purl.uniprot.org/uniprot/A0A8C9N220|||http://purl.uniprot.org/uniprot/A0A8C9N2G2|||http://purl.uniprot.org/uniprot/A0A8C9N362|||http://purl.uniprot.org/uniprot/A0A8C9N3T0 ^@ Similarity ^@ Belongs to the villin/gelsolin family. http://togogenome.org/gene/9135:CANX ^@ http://purl.uniprot.org/uniprot/A0A8C9NCQ1 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/9135:AGPAT2 ^@ http://purl.uniprot.org/uniprot/A0A8C9U457 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/9135:CCR6 ^@ http://purl.uniprot.org/uniprot/A0A8C9MI56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/9135:FGF7 ^@ http://purl.uniprot.org/uniprot/A0A8C9MPQ0 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9135:ADORA3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NSI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/9135:ETS1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NZ15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:BROX ^@ http://purl.uniprot.org/uniprot/A0A8C9MY31 ^@ Similarity ^@ Belongs to the BROX family. http://togogenome.org/gene/9135:ACAT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MNP3 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9135:LOC103814008 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGQ4 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9135:WNT3A ^@ http://purl.uniprot.org/uniprot/A0A8C9MTH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9135:DPP4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NIB6|||http://purl.uniprot.org/uniprot/A0A8C9NNI7 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the peptidase S9B family. DPPIV subfamily.|||Cell junction|||Cell membrane|||Membrane raft|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/9135:NUP210 ^@ http://purl.uniprot.org/uniprot/A0A8C9UED6 ^@ Similarity ^@ Belongs to the NUP210 family. http://togogenome.org/gene/9135:LOC103821605 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYP5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9135:SLC25A20 ^@ http://purl.uniprot.org/uniprot/A0A8C9MSU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9135:LOC103820042 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLU1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the claudin family.|||Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9135:ASPA ^@ http://purl.uniprot.org/uniprot/A0A8C9N8N0 ^@ Cofactor|||Similarity ^@ Belongs to the AspA/AstE family. Aspartoacylase subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9135:HACL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPW7 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/9135:ARRDC3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MWG6 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9135:F3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NFG1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tissue factor family.|||Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.|||Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. http://togogenome.org/gene/9135:BICC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BicC family.|||Cytoplasm http://togogenome.org/gene/9135:ATP12A ^@ http://purl.uniprot.org/uniprot/A0A8C9UDY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane http://togogenome.org/gene/9135:SEC22A ^@ http://purl.uniprot.org/uniprot/A0A8C9NEJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/9135:AMDHD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UBW9 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. HutI family. http://togogenome.org/gene/9135:EP300 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQK9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9135:NUDT2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NV15 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/9135:MUSTN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KSS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MUSTANG family.|||Nucleus http://togogenome.org/gene/9135:ALG12 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:IAH1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCQ8 ^@ Function|||Similarity ^@ Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.|||Probable lipase. http://togogenome.org/gene/9135:LOC103824904 ^@ http://purl.uniprot.org/uniprot/A0A8C9U7P6 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9135:AGT ^@ http://purl.uniprot.org/uniprot/A0A8C9MIZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family.|||Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.|||Secreted|||Stimulates aldosterone release. http://togogenome.org/gene/9135:CHL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1L1 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. http://togogenome.org/gene/9135:OPN5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NLY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9135:XRCC3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Cytoplasm|||Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.|||Nucleus http://togogenome.org/gene/9135:MTFR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MH45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/9135:SLC37A3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N6X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/9135:HGFAC ^@ http://purl.uniprot.org/uniprot/A0A8C9UH79 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:LOC103826777 ^@ http://purl.uniprot.org/uniprot/A0A8C9MPT6 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/9135:HSPB1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MS11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||spindle http://togogenome.org/gene/9135:IRF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N678 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Nucleus http://togogenome.org/gene/9135:FAM76A ^@ http://purl.uniprot.org/uniprot/A0A8C9UCH4 ^@ Similarity ^@ Belongs to the FAM76 family. http://togogenome.org/gene/9135:PCMTD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NI91 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/9135:LOC103821606 ^@ http://purl.uniprot.org/uniprot/A0A8C9MY88 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9135:PKN3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MP50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Nucleus http://togogenome.org/gene/9135:SCAMP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9135:ADGRG2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NIR4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:ATP1B4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQM1|||http://purl.uniprot.org/uniprot/A0A8C9UI79 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9135:LOC103818805 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGR2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/9135:ZCCHC8 ^@ http://purl.uniprot.org/uniprot/A0A8C9N4Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZCCHC8 family.|||nucleoplasm http://togogenome.org/gene/9135:XYLT2 ^@ http://purl.uniprot.org/uniprot/A0A8C9KVQ4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 14 family. XylT subfamily.|||Golgi apparatus membrane|||Membrane|||Monomer. http://togogenome.org/gene/9135:A1CF ^@ http://purl.uniprot.org/uniprot/A0A8C9MKI1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9135:CIT ^@ http://purl.uniprot.org/uniprot/A0A8C9U7N0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cytoplasm|||Plays a role in cytokinesis. Displays serine/threonine protein kinase activity. http://togogenome.org/gene/9135:HEPHL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9U6E4 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9135:NQO2 ^@ http://purl.uniprot.org/uniprot/A0A8C9KZ87 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/9135:LOC103820662 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNF-like-inhibitor family.|||Secreted http://togogenome.org/gene/9135:TMEM35A ^@ http://purl.uniprot.org/uniprot/A0A8C9UI88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/9135:ST6GALNAC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9135:CAMSAP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NC42|||http://purl.uniprot.org/uniprot/A0A8C9UEM0 ^@ Domain|||Similarity ^@ Belongs to the CAMSAP1 family.|||The CKK domain binds microtubules. http://togogenome.org/gene/9135:ZNF330 ^@ http://purl.uniprot.org/uniprot/A0A8C9NFN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOA36 family.|||nucleolus http://togogenome.org/gene/9135:CERS5 ^@ http://purl.uniprot.org/uniprot/A0A8C9UCQ6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9135:DPH2 ^@ http://purl.uniprot.org/uniprot/A0A8C9L2K1 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family. DPH2 subfamily.|||Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit. http://togogenome.org/gene/9135:CCNE1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKV3 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9135:IP6K1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NE70 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9135:HNRNPAB ^@ http://purl.uniprot.org/uniprot/A0A8C9N9X5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9135:ANAPC13 ^@ http://purl.uniprot.org/uniprot/A0A8C9U8J3 ^@ Function|||Similarity ^@ Belongs to the APC13 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. http://togogenome.org/gene/9135:SLC46A2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHB2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:RTEL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NK01 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.|||Belongs to the helicase family. RAD3/XPD subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9135:SEMA3C ^@ http://purl.uniprot.org/uniprot/A0A8C9UD20 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9135:EAF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MF24 ^@ Similarity ^@ Belongs to the EAF family. http://togogenome.org/gene/9135:ATP6V1G3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NBV6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9135:SEMA3D ^@ http://purl.uniprot.org/uniprot/A0A8C9N0N3 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:PHF20 ^@ http://purl.uniprot.org/uniprot/A0A8C9UFC6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:ESR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MSM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9135:PWWP3A ^@ http://purl.uniprot.org/uniprot/A0A8C9MU65 ^@ Similarity ^@ Belongs to the PWWP3A family. http://togogenome.org/gene/9135:AQP5 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9135:LOC103813172 ^@ http://purl.uniprot.org/uniprot/A0A8C9U1N0 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9135:RHPN2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NBC8 ^@ Similarity ^@ Belongs to the RHPN family. http://togogenome.org/gene/9135:LOC103814104 ^@ http://purl.uniprot.org/uniprot/A0A8C9UFW6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:TACSTD2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTF4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPCAM family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:JUP ^@ http://purl.uniprot.org/uniprot/A0A8C9MX21 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9135:RGS5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NWX2 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. http://togogenome.org/gene/9135:KDM3A ^@ http://purl.uniprot.org/uniprot/A0A8C9UGR2 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM2 histone demethylase family.|||Binds 1 Fe(2+) ion per subunit.|||Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.|||Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.|||Nucleus|||The JmjC domain and the C6-type zinc-finger are required for the demethylation activity. http://togogenome.org/gene/9135:GLB1L ^@ http://purl.uniprot.org/uniprot/A0A8C9NH91 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/9135:LOC103824943 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9135:SLC25A13 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9135:MTFR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NI83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/9135:KIF24 ^@ http://purl.uniprot.org/uniprot/A0A8C9NNT9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9135:SMPDL3B ^@ http://purl.uniprot.org/uniprot/A0A8C9NLU5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) per subunit.|||Secreted http://togogenome.org/gene/9135:SLC16A6 ^@ http://purl.uniprot.org/uniprot/A0A8C9UFY4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:NT5DC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NLD3 ^@ Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family. http://togogenome.org/gene/9135:HSD3B7 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRL7 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9135:DRAM1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N581 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:IL12B ^@ http://purl.uniprot.org/uniprot/A0A8C9L686 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-12B family.|||Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.|||Secreted http://togogenome.org/gene/9135:LOC103814987 ^@ http://purl.uniprot.org/uniprot/A0A8C9MF45 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9135:SUPT3H ^@ http://purl.uniprot.org/uniprot/A0A8C9NJ69|||http://purl.uniprot.org/uniprot/A0A8C9UGB5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:SNU13 ^@ http://purl.uniprot.org/uniprot/A0A8C9MR80 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/9135:LOC103820060 ^@ http://purl.uniprot.org/uniprot/A0A8C9N833 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9135:MON1A ^@ http://purl.uniprot.org/uniprot/A0A8C9KSP8 ^@ Function|||Similarity ^@ Belongs to the MON1/SAND family.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/9135:SNCG ^@ http://purl.uniprot.org/uniprot/A0A8C9MJC7 ^@ Similarity|||Subunit ^@ Belongs to the synuclein family.|||May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation. http://togogenome.org/gene/9135:PYROXD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MW07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.|||sarcomere http://togogenome.org/gene/9135:PIP4P2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MH93 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9135:BRINP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVE7 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9135:SAMD8 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9135:RSPO4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJR6 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9135:ATP11A ^@ http://purl.uniprot.org/uniprot/A0A8C9MN50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9135:LOC103821977 ^@ http://purl.uniprot.org/uniprot/A0A8C9KXK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9135:MAN1A2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UEW5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9135:FBXO9 ^@ http://purl.uniprot.org/uniprot/A0A8C9ND79 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9).|||Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and acts as a regulator of mTOR signaling. http://togogenome.org/gene/9135:RNF7 ^@ http://purl.uniprot.org/uniprot/A0A8C9KSA7 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/9135:FLNB ^@ http://purl.uniprot.org/uniprot/A0A8C9MKY8|||http://purl.uniprot.org/uniprot/A0A8C9ML50|||http://purl.uniprot.org/uniprot/A0A8C9ML60 ^@ Similarity ^@ Belongs to the filamin family. http://togogenome.org/gene/9135:BRS3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:LOC103815382 ^@ http://purl.uniprot.org/uniprot/A0A8C9UHC1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.|||Nucleus http://togogenome.org/gene/9135:SMC3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NT98 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC3 subfamily.|||Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.|||Nucleus|||centromere http://togogenome.org/gene/9135:GPR83 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJZ5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:MXRA8 ^@ http://purl.uniprot.org/uniprot/A0A8C9NWI7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9135:PFDN4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MED5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/9135:OSBPL8 ^@ http://purl.uniprot.org/uniprot/A0A8C9N340 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9135:MATK ^@ http://purl.uniprot.org/uniprot/A0A8C9L2S1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9135:LOC103815508 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZR4 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9135:SHH ^@ http://purl.uniprot.org/uniprot/A0A8C9MXY6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hedgehog family.|||Cell membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Multimer.|||The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.|||The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. http://togogenome.org/gene/9135:DCLRE1B ^@ http://purl.uniprot.org/uniprot/A0A8C9UHC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9135:SLC25A25 ^@ http://purl.uniprot.org/uniprot/A0A8C9MV01|||http://purl.uniprot.org/uniprot/A0A8C9MVQ8|||http://purl.uniprot.org/uniprot/A0A8C9UBF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9135:CMTM8 ^@ http://purl.uniprot.org/uniprot/A0A8C9MEU5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:NEMF ^@ http://purl.uniprot.org/uniprot/A0A8C9MEY0 ^@ Similarity ^@ Belongs to the NEMF family. http://togogenome.org/gene/9135:CCN4 ^@ http://purl.uniprot.org/uniprot/A0A8C9UCU1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9135:PHACTR3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRZ1 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/9135:LOC103820087 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTK8|||http://purl.uniprot.org/uniprot/A0A8C9MVF8 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9135:TDP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MXN1 ^@ Subcellular Location Annotation ^@ PML body http://togogenome.org/gene/9135:TPX2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TPX2 family.|||Nucleus|||spindle pole http://togogenome.org/gene/9135:PSAT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NM02 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.|||Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. http://togogenome.org/gene/9135:CEP63 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRI3|||http://purl.uniprot.org/uniprot/A0A8C9U8J7 ^@ Similarity ^@ Belongs to the CEP63 family. http://togogenome.org/gene/9135:UBE2C ^@ http://purl.uniprot.org/uniprot/A0A8C9NMJ4 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9135:SYK ^@ http://purl.uniprot.org/uniprot/A0A8C9NKA2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. http://togogenome.org/gene/9135:SLC29A3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NUB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/9135:LOC103816299 ^@ http://purl.uniprot.org/uniprot/A0A8C9NT84 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/9135:LOC103824215 ^@ http://purl.uniprot.org/uniprot/A0A8C9UIQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9135:GPX7 ^@ http://purl.uniprot.org/uniprot/A0A8C9MS69 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9135:ARMC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJN8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9135:CLCN4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NHG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/9135:PTBP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRE8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:PIGS ^@ http://purl.uniprot.org/uniprot/A0A8C9MVC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGS family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:BCAR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/9135:SYT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZR9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||synaptic vesicle membrane http://togogenome.org/gene/9135:LOC103819192 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAA0 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9135:PITPNM1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N7B8 ^@ Similarity ^@ Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. http://togogenome.org/gene/9135:ZC3H12B ^@ http://purl.uniprot.org/uniprot/A0A8C9NS10 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/9135:CSAD ^@ http://purl.uniprot.org/uniprot/A0A8C9N230 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9135:PARPBP ^@ http://purl.uniprot.org/uniprot/A0A8C9N645|||http://purl.uniprot.org/uniprot/A0A8C9N9I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PARI family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:GABARAPL2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8P0 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9135:ZNF532 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHV6 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9135:PIK3CB ^@ http://purl.uniprot.org/uniprot/A0A8C9NWD2 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9135:KCNA4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.|||Cell membrane|||Membrane|||axon http://togogenome.org/gene/9135:CFAP418 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKB4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in photoreceptor outer segment disk morphogenesis.|||Photoreceptor inner segment http://togogenome.org/gene/9135:NPFFR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MM87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9135:GMNN ^@ http://purl.uniprot.org/uniprot/A0A8C9MYL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the geminin family.|||Nucleus http://togogenome.org/gene/9135:THUMPD3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRH3 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9135:MAN1B1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCC5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9135:IARS2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MS99 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9135:FGFBP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9KWE1 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/9135:OSGEPL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKI9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Mitochondrion|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. http://togogenome.org/gene/9135:ATP5PF ^@ http://purl.uniprot.org/uniprot/A0A8C9NUD1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ATPase subunit F6 family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/9135:RRAGC ^@ http://purl.uniprot.org/uniprot/A0A8C9NQT7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9135:PLA2G4A ^@ http://purl.uniprot.org/uniprot/A0A8C9NA03 ^@ Domain ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding. http://togogenome.org/gene/9135:TAMM41 ^@ http://purl.uniprot.org/uniprot/A0A8C9NB78 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAM41 family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Mitochondrion inner membrane http://togogenome.org/gene/9135:TFAP2B ^@ http://purl.uniprot.org/uniprot/A0A8C9NLR7 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/9135:SYF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVV9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYF2 family.|||Involved in pre-mRNA splicing.|||May be part of a spliceosome complex.|||Nucleus http://togogenome.org/gene/9135:PSEN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJW0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Cytoplasmic granule|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||Synapse|||The PAL motif is required for normal active site conformation.|||axon|||neuron projection http://togogenome.org/gene/9135:CHRNB4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9135:SFRP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UF79 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:LOC103816423 ^@ http://purl.uniprot.org/uniprot/A0A8C9KTI4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:SNX20 ^@ http://purl.uniprot.org/uniprot/A0A8C9MNM4 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Membrane http://togogenome.org/gene/9135:EIF4E ^@ http://purl.uniprot.org/uniprot/A0A8C9NM61 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9135:LOC103820838 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHF5 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9135:LOC103818463 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-catenin family.|||Belongs to the eutherian X-chromosome-specific Armcx family.|||Membrane|||Vacuole membrane http://togogenome.org/gene/9135:SLC25A27 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9135:LOC103813311 ^@ http://purl.uniprot.org/uniprot/A0A8C9MSX9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9135:RPA3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NHU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 3 family.|||Nucleus http://togogenome.org/gene/9135:ALDH1A2 ^@ http://purl.uniprot.org/uniprot/A0A8C9KT16|||http://purl.uniprot.org/uniprot/A0A8C9L2G5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9135:GTF2B ^@ http://purl.uniprot.org/uniprot/A0A8C9NKM9 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/9135:LGR6 ^@ http://purl.uniprot.org/uniprot/A0A8C9MSS0|||http://purl.uniprot.org/uniprot/A0A8C9MTT7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:POLG ^@ http://purl.uniprot.org/uniprot/A0A8C9MS45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-A family.|||Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.|||mitochondrion nucleoid http://togogenome.org/gene/9135:LTA4H ^@ http://purl.uniprot.org/uniprot/A0A8C9MWL7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/9135:CLCN3 ^@ http://purl.uniprot.org/uniprot/A0A8C9UDK4|||http://purl.uniprot.org/uniprot/A0A8C9UE33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.|||Cell membrane|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9135:ELOVL5 ^@ http://purl.uniprot.org/uniprot/A0A8C9N9G7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL5 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||dendrite http://togogenome.org/gene/9135:OCSTAMP ^@ http://purl.uniprot.org/uniprot/A0A8C9UFY9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:PER2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UI29 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9135:ATP23 ^@ http://purl.uniprot.org/uniprot/A0A8C9KU21 ^@ Similarity ^@ Belongs to the peptidase M76 family. http://togogenome.org/gene/9135:AACS ^@ http://purl.uniprot.org/uniprot/A0A8C9NB92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Converts acetoacetate to acetoacetyl-CoA in the cytosol.|||cytosol http://togogenome.org/gene/9135:PPP2R5A ^@ http://purl.uniprot.org/uniprot/A0A8C9MSU8 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family. http://togogenome.org/gene/9135:SFXN2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NVC2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9135:LOC103822517 ^@ http://purl.uniprot.org/uniprot/A0A8C9NBU4 ^@ Caution|||Function|||Subunit ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.|||Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. http://togogenome.org/gene/9135:IPPK ^@ http://purl.uniprot.org/uniprot/A0A8C9NCJ9 ^@ Domain|||Function|||Similarity ^@ Belongs to the IPK1 type 2 family.|||Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).|||The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2. http://togogenome.org/gene/9135:CILP ^@ http://purl.uniprot.org/uniprot/A0A8C9N6C6 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9135:KLC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUI4|||http://purl.uniprot.org/uniprot/A0A8C9UA89 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/9135:ARPC2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NIT4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC2 family.|||Cell projection|||Component of the Arp2/3 complex.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/9135:KHDRBS3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N040 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KHDRBS family.|||Cytoplasm http://togogenome.org/gene/9135:TRIM32 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVP8 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/9135:EML4 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2P5 ^@ Similarity ^@ Belongs to the WD repeat EMAP family. http://togogenome.org/gene/9135:PSMB2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NP54 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:HIKESHI ^@ http://purl.uniprot.org/uniprot/A0A8C9L4N4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.|||Belongs to the OPI10 family.|||Cytoplasm|||Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.|||Nucleus|||cytosol http://togogenome.org/gene/9135:TTC36 ^@ http://purl.uniprot.org/uniprot/A0A8C9NYN7 ^@ Similarity ^@ Belongs to the TTC36 family. http://togogenome.org/gene/9135:PTPA ^@ http://purl.uniprot.org/uniprot/A0A8C9MP47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTPA-type PPIase family.|||Cytoplasm|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9135:GDPD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8J2 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9135:DDX24 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYJ8 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9135:ELOVL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KNL4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL1 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9135:LOC103821875 ^@ http://purl.uniprot.org/uniprot/A0A8C9KWV6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9135:TIPARP ^@ http://purl.uniprot.org/uniprot/A0A8C9N2Z6 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9135:PSEN2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQX6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||The PAL motif is required for normal active site conformation. http://togogenome.org/gene/9135:LOC103827199 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQH1 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/9135:ABL2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N532|||http://purl.uniprot.org/uniprot/A0A8C9N6H0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9135:MED24 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 24 family.|||Nucleus http://togogenome.org/gene/9135:LOC103822376 ^@ http://purl.uniprot.org/uniprot/A0A8C9MXK8 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/9135:LOC103824465 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZ02 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9135:SLC1A4 ^@ http://purl.uniprot.org/uniprot/A0A8C9KVT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9135:LDAF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8X9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LDAF1 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Membrane http://togogenome.org/gene/9135:DDX27 ^@ http://purl.uniprot.org/uniprot/A0A8C9NHC6 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9135:RNH1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKM8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.|||Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. http://togogenome.org/gene/9135:ACVR2B ^@ http://purl.uniprot.org/uniprot/A0A8C9MVD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9135:AQP11 ^@ http://purl.uniprot.org/uniprot/A0A8C9ME59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.|||Membrane http://togogenome.org/gene/9135:CDC42SE2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NK07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/9135:MMUT ^@ http://purl.uniprot.org/uniprot/A0A8C9NJB8 ^@ Function|||Similarity ^@ Belongs to the methylmalonyl-CoA mutase family.|||Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. http://togogenome.org/gene/9135:CDC42BPA ^@ http://purl.uniprot.org/uniprot/A0A8C9NQV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.|||lamellipodium http://togogenome.org/gene/9135:CRYAB ^@ http://purl.uniprot.org/uniprot/A0A8C9MXP5 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/9135:ATP6AP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9U6H9 ^@ Similarity ^@ Belongs to the vacuolar ATPase subunit S1 family. http://togogenome.org/gene/9135:DNAL4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQ19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9135:TDRD3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NR70 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1. http://togogenome.org/gene/9135:TMEM116 ^@ http://purl.uniprot.org/uniprot/A0A8C9MY66 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:SOD2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NBQ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems.|||Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.|||Homotetramer.|||Mitochondrion matrix http://togogenome.org/gene/9135:OLAH ^@ http://purl.uniprot.org/uniprot/A0A8C9NB01 ^@ Similarity ^@ Belongs to the thioesterase family. http://togogenome.org/gene/9135:LOC103827017 ^@ http://purl.uniprot.org/uniprot/A0A8C9MNS0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane raft http://togogenome.org/gene/9135:PRPF18 ^@ http://purl.uniprot.org/uniprot/A0A8C9N5K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP18 family.|||Nucleus speckle http://togogenome.org/gene/9135:LOC103824309 ^@ http://purl.uniprot.org/uniprot/A0A8C9KRV2 ^@ Similarity ^@ Belongs to the ADP-ribosyl cyclase family. http://togogenome.org/gene/9135:SRP68 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHG5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP68 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9135:LOC103813137 ^@ http://purl.uniprot.org/uniprot/A0A8C9U1J6 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9135:TBL1XR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NEA7 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/9135:CEP162 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP162 family.|||centriole http://togogenome.org/gene/9135:ALG6 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:PDHX ^@ http://purl.uniprot.org/uniprot/A0A8C9MJR2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/9135:LOC103813751 ^@ http://purl.uniprot.org/uniprot/A0A8C9N3V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/9135:CAVIN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MWW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9135:LOC103812568 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGJ6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:LOC103817867 ^@ http://purl.uniprot.org/uniprot/A0A8C9N3F1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9135:CACFD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel flower family.|||Membrane http://togogenome.org/gene/9135:NPVF ^@ http://purl.uniprot.org/uniprot/A0A8C9NNS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FARP (FMRFamide related peptide) family.|||Secreted http://togogenome.org/gene/9135:PAPOLA ^@ http://purl.uniprot.org/uniprot/A0A8C9MYH0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Binds 2 magnesium ions. Also active with manganese.|||Nucleus|||Polymerase that creates the 3'-poly(A) tail of mRNA's. http://togogenome.org/gene/9135:ADCY8 ^@ http://purl.uniprot.org/uniprot/A0A8C9N038 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9135:STK40 ^@ http://purl.uniprot.org/uniprot/A0A8C9NR94 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.|||Nucleus http://togogenome.org/gene/9135:LOC103821278 ^@ http://purl.uniprot.org/uniprot/A0A8C9NI94 ^@ Function|||Similarity ^@ Belongs to the KCMF1 family.|||Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination. http://togogenome.org/gene/9135:CRB2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NU47 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:SCARB2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMY7|||http://purl.uniprot.org/uniprot/A0A8C9U6S3 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/9135:CLIC4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MW68 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9135:CPNE2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTP3 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9135:MFSD6 ^@ http://purl.uniprot.org/uniprot/A0A8C9MK47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. MFSD6 family.|||Membrane http://togogenome.org/gene/9135:LOC103822653 ^@ http://purl.uniprot.org/uniprot/A0A8C9UH89 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9135:SERPINI1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N624 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9135:ZDHHC8 ^@ http://purl.uniprot.org/uniprot/A0A8C9MP13 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9135:HMOX1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKG6 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/9135:ATPAF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP11 family.|||Mitochondrion http://togogenome.org/gene/9135:POLR2D ^@ http://purl.uniprot.org/uniprot/A0A8C9N3S4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9135:WNT8A ^@ http://purl.uniprot.org/uniprot/A0A8C9N9W4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9135:RNF10 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNF10 family.|||Cytoplasm http://togogenome.org/gene/9135:NID1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLU7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9135:HNF1A ^@ http://purl.uniprot.org/uniprot/A0A8C9MKL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HNF1 homeobox family.|||Nucleus http://togogenome.org/gene/9135:ALDH1L2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHS8 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.|||In the N-terminal section; belongs to the GART family. http://togogenome.org/gene/9135:KATNB1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTC3|||http://purl.uniprot.org/uniprot/A0A8C9MU89 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat KATNB1 family.|||Cytoplasm|||Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome.|||Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9135:SPOPL ^@ http://purl.uniprot.org/uniprot/A0A8C9N708 ^@ Similarity ^@ Belongs to the Tdpoz family. http://togogenome.org/gene/9135:B4GALT6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9135:AP1S2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJ34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||clathrin-coated pit http://togogenome.org/gene/9135:PSMD12 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGK1 ^@ Similarity ^@ Belongs to the proteasome subunit p55 family. http://togogenome.org/gene/9135:CALB2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MSD8 ^@ Function|||Similarity ^@ Belongs to the calbindin family.|||Calretinin is a calcium-binding protein which is abundant in auditory neurons. http://togogenome.org/gene/9135:TRMT1L ^@ http://purl.uniprot.org/uniprot/A0A8C9NAX1 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||May play a role in motor coordination and exploratory behavior. http://togogenome.org/gene/9135:PGM2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQ16 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9135:MOS ^@ http://purl.uniprot.org/uniprot/A0A8C9UFW3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:CLEC16A ^@ http://purl.uniprot.org/uniprot/A0A8C9NAE8 ^@ Similarity ^@ Belongs to the CLEC16A/gop-1 family. http://togogenome.org/gene/9135:GRIA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NFN7|||http://purl.uniprot.org/uniprot/A0A8C9NGN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9135:AP3S1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQD6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Membrane|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. http://togogenome.org/gene/9135:CABIN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJD5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:PTTG1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NB88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the securin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:TXNL4B ^@ http://purl.uniprot.org/uniprot/A0A8C9UI41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/9135:LOC103813335 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUQ2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9135:B3GNT4 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9135:LOC103823301 ^@ http://purl.uniprot.org/uniprot/A0A8C9NUE9 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Contains one covalently linked retinal chromophore.|||Membrane http://togogenome.org/gene/9135:STK39 ^@ http://purl.uniprot.org/uniprot/A0A8C9UHT5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/9135:NKX6-2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N3W2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:DYNLL2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9135:EIF3L ^@ http://purl.uniprot.org/uniprot/A0A8C9MM55 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit L family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm http://togogenome.org/gene/9135:POLR3H ^@ http://purl.uniprot.org/uniprot/A0A8C9UA24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9135:TMPRSS4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQR2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:LOC103813437 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2I2 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/9135:NR2C2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NV23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9135:BBS7 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFN2 ^@ Function|||Subunit ^@ Part of BBSome complex.|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. http://togogenome.org/gene/9135:TPD52L1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMG9 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9135:TOM1 ^@ http://purl.uniprot.org/uniprot/A0A8C9ML61 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/9135:TIMM17A ^@ http://purl.uniprot.org/uniprot/A0A8C9UB39 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9135:TXNIP ^@ http://purl.uniprot.org/uniprot/A0A8C9NC16 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9135:SUSD6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGL9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:CKAP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NHE4 ^@ Similarity ^@ Belongs to the CKAP2 family. http://togogenome.org/gene/9135:ATP6V0D2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGH4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9135:MYOZ2 ^@ http://purl.uniprot.org/uniprot/A0A8C9L3X7 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9135:LOC103812522 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLA1 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9135:VCL ^@ http://purl.uniprot.org/uniprot/A0A8C9U240 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.|||Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||adherens junction|||podosome http://togogenome.org/gene/9135:MASP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NLI4|||http://purl.uniprot.org/uniprot/A0A8C9NQ33 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:LOC103823199 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKN0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:CCT7 ^@ http://purl.uniprot.org/uniprot/A0A8C9NU93 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm|||Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. http://togogenome.org/gene/9135:TRAF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9L6J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9135:RBKS ^@ http://purl.uniprot.org/uniprot/A0A8C9N5Z5 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/9135:CEMIP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9KUN5 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/9135:PRKDC ^@ http://purl.uniprot.org/uniprot/A0A8C9NBL9|||http://purl.uniprot.org/uniprot/A0A8C9ND99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family.|||nucleolus http://togogenome.org/gene/9135:ATP2C1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MF55 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:PNPLA7 ^@ http://purl.uniprot.org/uniprot/A0A8C9N7C3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NTE family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:XRN2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGQ2 ^@ Function|||Similarity ^@ Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.|||Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. http://togogenome.org/gene/9135:NCF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCZ3 ^@ Similarity ^@ Belongs to the NCF2/NOXA1 family. http://togogenome.org/gene/9135:YWHAG ^@ http://purl.uniprot.org/uniprot/A0A8C9UAV5 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9135:RPF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9L098 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/9135:LOC103813937 ^@ http://purl.uniprot.org/uniprot/A0A8C9UIA9 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9135:LOC103827344 ^@ http://purl.uniprot.org/uniprot/A0A8C9ND61|||http://purl.uniprot.org/uniprot/A0A8C9NES3 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/9135:PRKCA ^@ http://purl.uniprot.org/uniprot/A0A8C9NHN8|||http://purl.uniprot.org/uniprot/A0A8C9NKZ1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.|||Cell membrane|||Cytoplasm|||Membrane|||Mitochondrion membrane|||Nucleus http://togogenome.org/gene/9135:DLX1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NU63 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:LOC103814507 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGM4 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9135:ACSL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N826 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. http://togogenome.org/gene/9135:LOC103813245 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9135:CYFIP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NVQ7 ^@ Similarity ^@ Belongs to the CYFIP family. http://togogenome.org/gene/9135:HCRTR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N839 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:LOC103822177 ^@ http://purl.uniprot.org/uniprot/A0A8C9NB20 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:RIOX2 ^@ http://purl.uniprot.org/uniprot/A0A8C9ND51 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ROX family. MINA53 subfamily.|||Binds 1 Fe(2+) ion per subunit.|||Nucleus|||Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. http://togogenome.org/gene/9135:DNAAF4 ^@ http://purl.uniprot.org/uniprot/A0A8C9KPX5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Dynein axonemal particle|||neuron projection http://togogenome.org/gene/9135:TOM1L2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1W6 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/9135:TSPAN14 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9135:HSPA8 ^@ http://purl.uniprot.org/uniprot/A0A8C9UDE0 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9135:NSUN6 ^@ http://purl.uniprot.org/uniprot/A0A8C9UE55 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9135:TJP3 ^@ http://purl.uniprot.org/uniprot/A0A8C9KW48|||http://purl.uniprot.org/uniprot/A0A8C9KW54 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9135:CLDN12 ^@ http://purl.uniprot.org/uniprot/A0A8C9NBS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Membrane|||tight junction http://togogenome.org/gene/9135:TOM1L1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKH3 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/9135:TSPAN18 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9135:LOC103816747 ^@ http://purl.uniprot.org/uniprot/A0A8C9MWA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Nucleus http://togogenome.org/gene/9135:LOC103812888 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGU6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space http://togogenome.org/gene/9135:CSNK1G1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRY1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/9135:LOC103817272 ^@ http://purl.uniprot.org/uniprot/A0A8C9UEN1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:LHX2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NSC7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:EXOSC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NU26 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9135:PTH ^@ http://purl.uniprot.org/uniprot/A0A8C9NTU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the parathyroid hormone family.|||PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.|||Secreted http://togogenome.org/gene/9135:PDIA4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NT51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9135:TMEM183A ^@ http://purl.uniprot.org/uniprot/A0A8C9MWH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM183 family.|||Membrane http://togogenome.org/gene/9135:PRPH2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/9135:GCAT ^@ http://purl.uniprot.org/uniprot/A0A8C9MLV5 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9135:RSPO1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQJ9 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9135:SGMS2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NI39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9135:TMEM242 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM242 family.|||Membrane http://togogenome.org/gene/9135:INTS7 ^@ http://purl.uniprot.org/uniprot/A0A8C9MS72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 7 family.|||Nucleus http://togogenome.org/gene/9135:EDNRA ^@ http://purl.uniprot.org/uniprot/A0A8C9NQ93 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/9135:RPS4X ^@ http://purl.uniprot.org/uniprot/A0A8C9NNL0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/9135:LOC103820367 ^@ http://purl.uniprot.org/uniprot/A0A8C9UG82 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:YDJC ^@ http://purl.uniprot.org/uniprot/A0A8C9MN72 ^@ Function|||Similarity ^@ Belongs to the YdjC deacetylase family.|||Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides. http://togogenome.org/gene/9135:ITPRIP ^@ http://purl.uniprot.org/uniprot/A0A8C9UI78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Membrane http://togogenome.org/gene/9135:POLR2F ^@ http://purl.uniprot.org/uniprot/A0A8C9MLV7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.|||Nucleus http://togogenome.org/gene/9135:MOGAT2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NTC0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:LOC103822357 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTG1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9135:ABRACL ^@ http://purl.uniprot.org/uniprot/A0A8C9MID6|||http://purl.uniprot.org/uniprot/A0A8C9U5F2 ^@ Similarity ^@ Belongs to the costars family. http://togogenome.org/gene/9135:RAMP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUD2 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/9135:SOGA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UDC8 ^@ Similarity ^@ Belongs to the SOGA family. http://togogenome.org/gene/9135:SFT2D1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/9135:PPEF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NK52 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/9135:TARDBP ^@ http://purl.uniprot.org/uniprot/A0A8C9NUL8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:NEMP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NEMP family.|||Nucleus inner membrane http://togogenome.org/gene/9135:CA5A ^@ http://purl.uniprot.org/uniprot/A0A8C9MWE1|||http://purl.uniprot.org/uniprot/A0A8C9MWH2 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9135:CSRNP3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/9135:GSK3B ^@ http://purl.uniprot.org/uniprot/A0A8C9N5Y0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/9135:LOC103814714 ^@ http://purl.uniprot.org/uniprot/A0A8C9L695 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shugoshin family.|||centromere http://togogenome.org/gene/9135:RAMAC ^@ http://purl.uniprot.org/uniprot/A0A8C9MQ62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAM family.|||Nucleus http://togogenome.org/gene/9135:IGF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N654 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9135:ARFGEF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9L2A3 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||perinuclear region http://togogenome.org/gene/9135:LOC103822068 ^@ http://purl.uniprot.org/uniprot/A0A8C9MWV0 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9135:AQP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MT26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9135:TNK2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NIY1|||http://purl.uniprot.org/uniprot/A0A8C9NPV8 ^@ Subcellular Location Annotation ^@ Membrane|||Nucleus http://togogenome.org/gene/9135:NR2C1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UC13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9135:GNPDA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KXH8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/9135:CASR ^@ http://purl.uniprot.org/uniprot/A0A8C9UEX5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9135:SPON1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYX5 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9135:XPOT ^@ http://purl.uniprot.org/uniprot/A0A8C9MGY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus|||tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. http://togogenome.org/gene/9135:PIGK ^@ http://purl.uniprot.org/uniprot/A0A8C9NNV1 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C13 family.|||Forms a complex with PIGT, PIGS, PIGU and GAA1. http://togogenome.org/gene/9135:EIF4EBP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NXF2 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/9135:GRHL2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MM99 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:RTN4IP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KQ88 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9135:SNRPD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. http://togogenome.org/gene/9135:CLTRN ^@ http://purl.uniprot.org/uniprot/A0A8C9NL95 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9135:PLOD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHX3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9135:FAM118A ^@ http://purl.uniprot.org/uniprot/A0A8C9MI46 ^@ Similarity ^@ Belongs to the FAM118 family. http://togogenome.org/gene/9135:MAFF ^@ http://purl.uniprot.org/uniprot/A0A8C9MML2 ^@ Similarity ^@ Belongs to the bZIP family. Maf subfamily. http://togogenome.org/gene/9135:GPNMB ^@ http://purl.uniprot.org/uniprot/A0A8C9NM05 ^@ Similarity ^@ Belongs to the PMEL/NMB family. http://togogenome.org/gene/9135:LOC103823012 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKT0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:LOC103813054 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVC9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.|||Binds 1 FAD per subunit.|||May have a photoreceptor function. http://togogenome.org/gene/9135:IFT57 ^@ http://purl.uniprot.org/uniprot/A0A8C9NWM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT57 family.|||cilium basal body http://togogenome.org/gene/9135:PDE1A ^@ http://purl.uniprot.org/uniprot/A0A8C9KXS9 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9135:DHCR7 ^@ http://purl.uniprot.org/uniprot/A0A8C9UCM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/9135:HPDL ^@ http://purl.uniprot.org/uniprot/A0A8C9L2V8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 4HPPD family.|||Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/9135:PLCG2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUW4 ^@ Function ^@ Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. http://togogenome.org/gene/9135:NLGN4X ^@ http://purl.uniprot.org/uniprot/A0A8C9MPZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:RAB3B ^@ http://purl.uniprot.org/uniprot/A0A8C9MSI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9135:TGFB2 ^@ http://purl.uniprot.org/uniprot/A0A8C9U8U7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.|||extracellular matrix http://togogenome.org/gene/9135:STS ^@ http://purl.uniprot.org/uniprot/A0A8C9U812 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9135:SLC20A2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGM4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/9135:LOC103816564 ^@ http://purl.uniprot.org/uniprot/A0A8C9KX07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9135:PTPRZ1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KVJ0|||http://purl.uniprot.org/uniprot/A0A8C9KVN1|||http://purl.uniprot.org/uniprot/A0A8C9L0V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.|||Membrane http://togogenome.org/gene/9135:ZBTB8OS ^@ http://purl.uniprot.org/uniprot/A0A8C9MPH8 ^@ Similarity|||Subunit ^@ Belongs to the archease family.|||Component of the tRNA-splicing ligase complex. http://togogenome.org/gene/9135:KIF3B ^@ http://purl.uniprot.org/uniprot/A0A8C9NL84 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9135:CHST1 ^@ http://purl.uniprot.org/uniprot/A0A8C9U1R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9135:LOC103813352 ^@ http://purl.uniprot.org/uniprot/A0A8C9UBC1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9135:TES ^@ http://purl.uniprot.org/uniprot/A0A8C9UDH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prickle / espinas / testin family.|||focal adhesion http://togogenome.org/gene/9135:NINJ2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MM81|||http://purl.uniprot.org/uniprot/A0A8C9MMA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ninjurin family.|||Membrane http://togogenome.org/gene/9135:CDKAL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9L1K2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9135:SLC39A14 ^@ http://purl.uniprot.org/uniprot/A0A8C9MSB5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:C21H1orf174 ^@ http://purl.uniprot.org/uniprot/A0A8C9L3Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0688 family.|||Nucleus http://togogenome.org/gene/9135:MTIF3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUG4 ^@ Similarity ^@ Belongs to the IF-3 family. http://togogenome.org/gene/9135:INS ^@ http://purl.uniprot.org/uniprot/A0A8C9MM83 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Heterodimer of a B chain and an A chain linked by two disulfide bonds.|||Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.|||Secreted http://togogenome.org/gene/9135:ARF6 ^@ http://purl.uniprot.org/uniprot/A0A8C9ME01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Cell membrane|||Cleavage furrow|||Endosome membrane|||Midbody ring|||Recycling endosome membrane|||filopodium membrane|||ruffle http://togogenome.org/gene/9135:HAT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NSV6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HAT1 family.|||Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.|||Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). http://togogenome.org/gene/9135:RNMT ^@ http://purl.uniprot.org/uniprot/A0A8C9MY23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.|||In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.|||Nucleus http://togogenome.org/gene/9135:LOC103820072 ^@ http://purl.uniprot.org/uniprot/A0A8C9UAT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.|||Nucleus http://togogenome.org/gene/9135:MAGOH ^@ http://purl.uniprot.org/uniprot/A0A8C9MSD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/9135:BCO2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYS4 ^@ Cofactor|||Similarity ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/9135:SPECC1L ^@ http://purl.uniprot.org/uniprot/A0A8C9MJT3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytospin-A family.|||Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.|||May interact with both microtubules and actin cytoskeleton.|||cytoskeleton|||gap junction|||spindle http://togogenome.org/gene/9135:AOPEP ^@ http://purl.uniprot.org/uniprot/A0A8C9MMD2 ^@ Similarity ^@ Belongs to the peptidase M1 family. http://togogenome.org/gene/9135:KIF20B ^@ http://purl.uniprot.org/uniprot/A0A8C9NW39 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9135:NCDN ^@ http://purl.uniprot.org/uniprot/A0A8C9UHP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the neurochondrin family.|||Postsynapse http://togogenome.org/gene/9135:PDGFB ^@ http://purl.uniprot.org/uniprot/A0A8C9MPD2 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/9135:INSIG1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MXF1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/9135:SH3PXD2B ^@ http://purl.uniprot.org/uniprot/A0A8C9L297 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SH3PXD2 family.|||Cytoplasm http://togogenome.org/gene/9135:LOC103820078 ^@ http://purl.uniprot.org/uniprot/A0A8C9MU15 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NADPH--cytochrome P450 reductase family.|||Binds 1 FAD per monomer.|||Binds 1 FMN per monomer.|||Endoplasmic reticulum membrane|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. http://togogenome.org/gene/9135:ETS2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N948 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus|||Transcription factor. http://togogenome.org/gene/9135:CFAP97 ^@ http://purl.uniprot.org/uniprot/A0A8C9N3T9 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/9135:RPAP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MEF5 ^@ Similarity ^@ Belongs to the RPAP1 family. http://togogenome.org/gene/9135:SATB1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/9135:TMEM41B ^@ http://purl.uniprot.org/uniprot/A0A8C9MPX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/9135:SHROOM3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shroom family.|||cytoskeleton http://togogenome.org/gene/9135:ARSG ^@ http://purl.uniprot.org/uniprot/A0A8C9NJE7 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9135:RTCA ^@ http://purl.uniprot.org/uniprot/A0A8C9NGP6 ^@ Function|||Similarity ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. http://togogenome.org/gene/9135:SNX30 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHC7 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9135:KCNG1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NSW3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:WEE1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MR27 ^@ Cofactor|||Similarity ^@ Belongs to the protein kinase superfamily.|||Binds 2 magnesium ions per subunit. http://togogenome.org/gene/9135:RPL7 ^@ http://purl.uniprot.org/uniprot/A0A8C9KUY6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/9135:ATG16L1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIA1|||http://purl.uniprot.org/uniprot/A0A8C9MIC0 ^@ Similarity ^@ Belongs to the WD repeat ATG16 family. http://togogenome.org/gene/9135:LOC103817748 ^@ http://purl.uniprot.org/uniprot/A0A8C9NES8 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9135:LOC103820858 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/9135:LOC103826067 ^@ http://purl.uniprot.org/uniprot/A0A8C9NNR8 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/9135:LTN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQK4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LTN1 family.|||Component of the ribosome quality control complex (RQC).|||E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.|||cytosol http://togogenome.org/gene/9135:SSX2IP ^@ http://purl.uniprot.org/uniprot/A0A8C9NNC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIP family.|||adherens junction|||centriolar satellite http://togogenome.org/gene/9135:ETV1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NF69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9135:GRK4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRA1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9135:UTRN ^@ http://purl.uniprot.org/uniprot/A0A8C9MGY4 ^@ Function|||Subcellular Location Annotation ^@ May play a role in anchoring the cytoskeleton to the plasma membrane.|||cytoskeleton http://togogenome.org/gene/9135:GSKIP ^@ http://purl.uniprot.org/uniprot/A0A8C9MXV9 ^@ Similarity ^@ Belongs to the GSKIP family. http://togogenome.org/gene/9135:SLC4A7 ^@ http://purl.uniprot.org/uniprot/A0A8C9KPB0 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9135:CCNB2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NWF8 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9135:SRP54 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAE3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).|||Cytoplasm|||Endoplasmic reticulum|||Nucleus speckle|||The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.|||The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER. http://togogenome.org/gene/9135:MKNK1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIE7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:TATDN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MXG7|||http://purl.uniprot.org/uniprot/A0A8C9MY28 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/9135:SULF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KX63 ^@ Cofactor|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Binds 1 Ca(2+) ion per subunit.|||Cell surface|||Endoplasmic reticulum|||Golgi stack|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9135:RPS2 ^@ http://purl.uniprot.org/uniprot/A0A8C9U9W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS5 family.|||Nucleus http://togogenome.org/gene/9135:EEF2KMT ^@ http://purl.uniprot.org/uniprot/A0A8C9NDS0 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family. http://togogenome.org/gene/9135:SDHAF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N4L6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SDHAF2 family.|||Interacts with SDHA within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. http://togogenome.org/gene/9135:C26H6orf89 ^@ http://purl.uniprot.org/uniprot/A0A8C9UFW4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9135:RAB38 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9135:SGO2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shugoshin family.|||centromere http://togogenome.org/gene/9135:TSPAN5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9135:LPAR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UED4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cell surface|||Endosome|||Membrane http://togogenome.org/gene/9135:IMPACT ^@ http://purl.uniprot.org/uniprot/A0A8C9NDK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IMPACT family.|||Cytoplasm http://togogenome.org/gene/9135:CNDP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MXL4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9135:MAPK14 ^@ http://purl.uniprot.org/uniprot/A0A8C9NLR1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9135:OXSM ^@ http://purl.uniprot.org/uniprot/A0A8C9NQ05 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/9135:LOC103826301 ^@ http://purl.uniprot.org/uniprot/A0A8C9L091 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9135:AHSA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2U0 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/9135:PLA2G4B ^@ http://purl.uniprot.org/uniprot/A0A8C9KXE4|||http://purl.uniprot.org/uniprot/A0A8C9MEB5 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9135:ERG ^@ http://purl.uniprot.org/uniprot/A0A8C9N685|||http://purl.uniprot.org/uniprot/A0A8C9N959|||http://purl.uniprot.org/uniprot/A0A8C9NBG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9135:LOC103815348 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGV7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9135:HUS1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRY3 ^@ Similarity ^@ Belongs to the HUS1 family. http://togogenome.org/gene/9135:XIAP ^@ http://purl.uniprot.org/uniprot/A0A8C9UIP6 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/9135:EEIG1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UBF4 ^@ Similarity ^@ Belongs to the EEIG family. http://togogenome.org/gene/9135:ROCK1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N7N7 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by RHOA binding. Inhibited by Y-27632.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cytoplasm|||Homodimer.|||Membrane|||Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. http://togogenome.org/gene/9135:HTR1F ^@ http://purl.uniprot.org/uniprot/A0A8C9ND58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.|||Membrane http://togogenome.org/gene/9135:DRAXIN ^@ http://purl.uniprot.org/uniprot/A0A8C9MI35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the draxin family.|||Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord.|||Secreted http://togogenome.org/gene/9135:CHST15 ^@ http://purl.uniprot.org/uniprot/A0A8C9NEZ5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9135:TIMP3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKS0 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/9135:C2H7orf25 ^@ http://purl.uniprot.org/uniprot/A0A8C9NSU3 ^@ Similarity ^@ Belongs to the UPF0415 family. http://togogenome.org/gene/9135:GFUS ^@ http://purl.uniprot.org/uniprot/A0A8C9L241 ^@ Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.|||Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. http://togogenome.org/gene/9135:CEP55 ^@ http://purl.uniprot.org/uniprot/A0A8C9NWP7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9135:ST3GAL3 ^@ http://purl.uniprot.org/uniprot/A0A8C9KT55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9135:EPS8L2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NBF4 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/9135:GPR34 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDQ4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:ESYT3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the extended synaptotagmin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:SLC15A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NT44 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Interacts (via extracellular domain region) with trypsin.|||Membrane http://togogenome.org/gene/9135:LOC103823865 ^@ http://purl.uniprot.org/uniprot/A0A8C9N120 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9135:GRIA4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9135:FZD9 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKL4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:LOC103821589 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:CD8B ^@ http://purl.uniprot.org/uniprot/A0A8C9UH80 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:HOXA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMS2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:LOC103818472 ^@ http://purl.uniprot.org/uniprot/A0A8C9MI18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/9135:RBL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDD5|||http://purl.uniprot.org/uniprot/A0A8C9NFG8|||http://purl.uniprot.org/uniprot/A0A8C9NFH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the retinoblastoma protein (RB) family.|||Nucleus http://togogenome.org/gene/9135:BCORL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NS79 ^@ Similarity ^@ Belongs to the BCOR family. http://togogenome.org/gene/9135:KIF2C ^@ http://purl.uniprot.org/uniprot/A0A8C9L2U0|||http://purl.uniprot.org/uniprot/A0A8C9L555 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9135:ACADM ^@ http://purl.uniprot.org/uniprot/A0A8C9UCC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9135:PEMT ^@ http://purl.uniprot.org/uniprot/A0A8C9N2Y9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.|||Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9135:CD2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NF71 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:DDIT4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NS15 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/9135:CHUK ^@ http://purl.uniprot.org/uniprot/A0A8C9MMH9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9135:STEAP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NFK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9135:LYRM7 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJZ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.|||Belongs to the complex I LYR family.|||Interacts with UQCRFS1.|||Mitochondrion matrix http://togogenome.org/gene/9135:LOC103813354 ^@ http://purl.uniprot.org/uniprot/A0A8C9MU87 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9135:RAB11FIP4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NNK8 ^@ Subcellular Location Annotation ^@ Cleavage furrow|||Endosome membrane|||Membrane|||Midbody|||Recycling endosome membrane http://togogenome.org/gene/9135:ELOVL2 ^@ http://purl.uniprot.org/uniprot/A0A8C9L3L1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL2 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9135:ORC5 ^@ http://purl.uniprot.org/uniprot/A0A8C9MY86 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:SLC6A9 ^@ http://purl.uniprot.org/uniprot/A0A8C9KQ85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:FAM110C ^@ http://purl.uniprot.org/uniprot/A0A8C9NBX6 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/9135:PDP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCK3 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9135:TALDO1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N6M0 ^@ Function|||Similarity ^@ Belongs to the transaldolase family. Type 1 subfamily.|||Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate. http://togogenome.org/gene/9135:OIP5 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFZ3 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.|||centromere http://togogenome.org/gene/9135:ZW10 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZW10 family.|||kinetochore http://togogenome.org/gene/9135:GADD45G ^@ http://purl.uniprot.org/uniprot/A0A8C9NKC1 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/9135:NDNF ^@ http://purl.uniprot.org/uniprot/A0A8C9L4N6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9135:SSTR3 ^@ http://purl.uniprot.org/uniprot/A0A8C9ML93 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:MRE11 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MRE11/RAD32 family.|||Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.|||Nucleus http://togogenome.org/gene/9135:LOC108961658 ^@ http://purl.uniprot.org/uniprot/A0A8C9NW86 ^@ Function ^@ The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution. http://togogenome.org/gene/9135:PDCD4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRJ4 ^@ Similarity ^@ Belongs to the PDCD4 family. http://togogenome.org/gene/9135:LOC103826618 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX16 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9135:SLC5A3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZ96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9135:FICD ^@ http://purl.uniprot.org/uniprot/A0A8C9MWP0 ^@ Similarity ^@ Belongs to the fic family. http://togogenome.org/gene/9135:CSGALNACT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UFN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9135:RPL36A ^@ http://purl.uniprot.org/uniprot/A0A8C9NUU9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9135:PSMB1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIK2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:LOC103826977 ^@ http://purl.uniprot.org/uniprot/A0A8C9ME61 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9135:PLCD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVP7 ^@ Cofactor ^@ Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain. http://togogenome.org/gene/9135:DDX47 ^@ http://purl.uniprot.org/uniprot/A0A8C9MSW8 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily. http://togogenome.org/gene/9135:LOC103816462 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9135:TMPRSS2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N6S4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:FAM13A ^@ http://purl.uniprot.org/uniprot/A0A8C9NLL6 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9135:LOC103814390 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPX3 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the peptidase S9B family. DPPIV subfamily.|||Cell junction|||Cell membrane|||Membrane raft|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/9135:DPY30 ^@ http://purl.uniprot.org/uniprot/A0A8C9NB04 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/9135:NAT10 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2K6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.|||Interacts with THUMPD1.|||RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.|||nucleolus http://togogenome.org/gene/9135:GAP43 ^@ http://purl.uniprot.org/uniprot/A0A8C9UDG7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neuromodulin family.|||Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.|||Cell membrane|||Membrane|||Palmitoylated. Palmitoylation is essential for plasma membrane association.|||Synapse|||This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.|||filopodium membrane|||growth cone membrane http://togogenome.org/gene/9135:DPH5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NC96 ^@ Function|||Similarity ^@ Belongs to the diphthine synthase family.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/9135:CETP ^@ http://purl.uniprot.org/uniprot/A0A8C9MUI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Secreted http://togogenome.org/gene/9135:LOC103815302 ^@ http://purl.uniprot.org/uniprot/A0A8C9NB57|||http://purl.uniprot.org/uniprot/A0A8C9UF01 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:SGMS1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9135:CACNG1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NM18 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.|||Membrane|||Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.|||sarcolemma http://togogenome.org/gene/9135:SLC25A4 ^@ http://purl.uniprot.org/uniprot/A0A8C9N5H5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/9135:NRG3 ^@ http://purl.uniprot.org/uniprot/A0A8C9U3G8 ^@ Caution|||Similarity ^@ Belongs to the neuregulin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:DHRS7 ^@ http://purl.uniprot.org/uniprot/A0A8C9MPG8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9135:ETFRF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UDH5 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9135:INTS2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAJ5 ^@ Similarity ^@ Belongs to the Integrator subunit 2 family. http://togogenome.org/gene/9135:TUBGCP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/9135:NDC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MSU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDC1 family.|||Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.|||Membrane|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/9135:FAM91A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MX95 ^@ Similarity ^@ Belongs to the FAM91 family. http://togogenome.org/gene/9135:IRF7 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPP2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:DHX9 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DEAH subfamily.|||Nucleus http://togogenome.org/gene/9135:ENTPD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UI31 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9135:IRF4 ^@ http://purl.uniprot.org/uniprot/A0A8C9L4G8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:RPSA ^@ http://purl.uniprot.org/uniprot/A0A8C9KYX1 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.|||Belongs to the universal ribosomal protein uS2 family.|||Cell membrane|||Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.|||Cytoplasm|||Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK.|||Nucleus|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis.|||This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. http://togogenome.org/gene/9135:STK3 ^@ http://purl.uniprot.org/uniprot/A0A8C9ML23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Nucleus http://togogenome.org/gene/9135:AGA ^@ http://purl.uniprot.org/uniprot/A0A8C9N8M5 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/9135:LOC103818081 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cleavage furrow|||Midbody|||cilium membrane|||spindle http://togogenome.org/gene/9135:DPF3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NHK1 ^@ Similarity ^@ Belongs to the requiem/DPF family. http://togogenome.org/gene/9135:NCOA3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NSY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/9135:TMEM35B ^@ http://purl.uniprot.org/uniprot/A0A8C9NSY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/9135:AMN ^@ http://purl.uniprot.org/uniprot/A0A8C9MVI6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9135:ZNF830 ^@ http://purl.uniprot.org/uniprot/A0A8C9MSI7 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus speckle http://togogenome.org/gene/9135:POP5 ^@ http://purl.uniprot.org/uniprot/A0A8C9U5K4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||nucleolus http://togogenome.org/gene/9135:BTD ^@ http://purl.uniprot.org/uniprot/A0A8C9UGY3 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9135:ZC3H12D ^@ http://purl.uniprot.org/uniprot/A0A8C9N1J6 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/9135:CPSF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MY35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/9135:UBL3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MW50 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9135:DIPK2B ^@ http://purl.uniprot.org/uniprot/A0A8C9NC15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/9135:PDE6D ^@ http://purl.uniprot.org/uniprot/A0A8C9NKJ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PDE6D/unc-119 family.|||Cytoplasmic vesicle membrane|||Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.|||Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.|||cilium basal body|||cytosol http://togogenome.org/gene/9135:LOC103817749 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAF1 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9135:LOC103816689 ^@ http://purl.uniprot.org/uniprot/A0A8C9U971 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9135:LOC103827099 ^@ http://purl.uniprot.org/uniprot/A0A8C9N4R8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9135:VAC14 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAC14 family.|||Endosome membrane|||Microsome membrane http://togogenome.org/gene/9135:DESI1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRQ3 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/9135:LOC103827373 ^@ http://purl.uniprot.org/uniprot/A0A8C9NG39 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9135:SLC5A7 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9135:HOOK1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MV91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hook family.|||cytoskeleton http://togogenome.org/gene/9135:NDUFB6 ^@ http://purl.uniprot.org/uniprot/A0A8C9UG34 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB6 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9135:GTPBP4 ^@ http://purl.uniprot.org/uniprot/A0A8C9N210 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/9135:MTOR ^@ http://purl.uniprot.org/uniprot/A0A8C9MIP3|||http://purl.uniprot.org/uniprot/A0A8C9U5J3 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. http://togogenome.org/gene/9135:FSHB ^@ http://purl.uniprot.org/uniprot/A0A8C9UCD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9135:DUSP6 ^@ http://purl.uniprot.org/uniprot/A0A8C9MXU3 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9135:GRAMD1B ^@ http://purl.uniprot.org/uniprot/A0A8C9UEF1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:BLVRA ^@ http://purl.uniprot.org/uniprot/A0A8C9NQS7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.|||Monomer.|||Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.|||cytosol http://togogenome.org/gene/9135:ST6GAL2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9135:IGF2R ^@ http://purl.uniprot.org/uniprot/A0A8C9NAW4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:NCBP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQM3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRM NCBP2 family.|||Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.|||Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.|||Nucleus http://togogenome.org/gene/9135:NDUFB3 ^@ http://purl.uniprot.org/uniprot/A0A8C9U258 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB3 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9135:NDUFV2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UDB7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. http://togogenome.org/gene/9135:GLRA2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NK11 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9135:CHD1L ^@ http://purl.uniprot.org/uniprot/A0A8C9N6I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/9135:TAF9B ^@ http://purl.uniprot.org/uniprot/A0A8C9ME89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family.|||Nucleus http://togogenome.org/gene/9135:ANAPC5 ^@ http://purl.uniprot.org/uniprot/A0A8C9N435 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC5 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||spindle http://togogenome.org/gene/9135:KCNJ8 ^@ http://purl.uniprot.org/uniprot/A0A8C9UD34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9135:INHBA ^@ http://purl.uniprot.org/uniprot/A0A8C9NS70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9135:HVCN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N0F0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hydrogen channel family.|||Homodimer.|||Membrane http://togogenome.org/gene/9135:ELOVL7 ^@ http://purl.uniprot.org/uniprot/A0A8C9N3U2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL7 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:LOC103817999 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJB3 ^@ Similarity ^@ Belongs to the GST superfamily. Theta family. http://togogenome.org/gene/9135:LOC108961603 ^@ http://purl.uniprot.org/uniprot/A0A8C9N4J2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:NPY5R ^@ http://purl.uniprot.org/uniprot/A0A8C9NAC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. http://togogenome.org/gene/9135:LOC103825988 ^@ http://purl.uniprot.org/uniprot/A0A8C9UFM2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:RPA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MWF5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.|||Belongs to the replication factor A protein 1 family.|||Component of the heterotrimeric canonical replication protein A complex (RPA).|||PML body http://togogenome.org/gene/9135:EEF1B2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFK4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the EF-1-beta/EF-1-delta family.|||EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.|||EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. http://togogenome.org/gene/9135:LOC103823091 ^@ http://purl.uniprot.org/uniprot/A0A8C9N860 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:AMOT ^@ http://purl.uniprot.org/uniprot/A0A8C9NUA9 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/9135:CEP70 ^@ http://purl.uniprot.org/uniprot/A0A8C9N744 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.|||Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.|||centrosome http://togogenome.org/gene/9135:THRB ^@ http://purl.uniprot.org/uniprot/A0A8C9NNQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.|||Nucleus http://togogenome.org/gene/9135:NMUR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGZ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/9135:NTRK2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MN49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/9135:ITIH5 ^@ http://purl.uniprot.org/uniprot/A0A8C9N5G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9135:CELF6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NU92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Nucleus http://togogenome.org/gene/9135:AMPD3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZZ6 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/9135:PITX3 ^@ http://purl.uniprot.org/uniprot/A0A8C9L4R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9135:GSTK1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJH2 ^@ Similarity ^@ Belongs to the GST superfamily. Kappa family. http://togogenome.org/gene/9135:ACOX3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/9135:QRFP ^@ http://purl.uniprot.org/uniprot/A0A8C9MLW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RFamide neuropeptide family.|||Secreted http://togogenome.org/gene/9135:UTP6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP6 family.|||nucleolus http://togogenome.org/gene/9135:PHTF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NLP4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:PFKFB2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NEG0 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9135:SEMA3A ^@ http://purl.uniprot.org/uniprot/A0A8C9N318 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:LOC103822463 ^@ http://purl.uniprot.org/uniprot/A0A8C9NFJ7 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9135:GMFB ^@ http://purl.uniprot.org/uniprot/A0A8C9MFG6 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily. http://togogenome.org/gene/9135:CHST9 ^@ http://purl.uniprot.org/uniprot/A0A8C9NE08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9135:LOC103813884 ^@ http://purl.uniprot.org/uniprot/A0A8C9KU12 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9135:VIPR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UB05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:LOC103824142 ^@ http://purl.uniprot.org/uniprot/A0A8C9NM73|||http://purl.uniprot.org/uniprot/A0A8C9NPS6|||http://purl.uniprot.org/uniprot/A0A8C9NTG2 ^@ Similarity ^@ Belongs to the CAND family. http://togogenome.org/gene/9135:HRH2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NHS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:LOC103826433 ^@ http://purl.uniprot.org/uniprot/A0A8C9UC27 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9135:DIS3L2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NM74 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation.|||Belongs to the RNR ribonuclease family. DIS3L2 subfamily.|||Cytoplasm|||P-body|||Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site. http://togogenome.org/gene/9135:GPR107 ^@ http://purl.uniprot.org/uniprot/A0A8C9MPN5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:WASHC5 ^@ http://purl.uniprot.org/uniprot/A0A8C9MY92 ^@ Similarity ^@ Belongs to the strumpellin family. http://togogenome.org/gene/9135:TOP2A ^@ http://purl.uniprot.org/uniprot/A0A8C9MYB9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase family.|||Homodimer.|||Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9135:SENP7 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQ30|||http://purl.uniprot.org/uniprot/A0A8C9NSF9|||http://purl.uniprot.org/uniprot/A0A8C9NW97 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9135:AGTR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UJ18 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MTUS1.|||Membrane http://togogenome.org/gene/9135:USP9X ^@ http://purl.uniprot.org/uniprot/A0A8C9UEY3 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9135:CFLAR ^@ http://purl.uniprot.org/uniprot/A0A8C9MGP2 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9135:CWF19L2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MM30 ^@ Similarity ^@ Belongs to the CWF19 family. http://togogenome.org/gene/9135:LOC103814506 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGI2 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9135:MTF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UG29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/9135:NR4A3 ^@ http://purl.uniprot.org/uniprot/A0A8C9UB97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9135:CCKAR ^@ http://purl.uniprot.org/uniprot/A0A8C9MNZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9135:HOXA3 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9135:MNAT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTE8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with CDK7 and cyclin H.|||Nucleus|||Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. http://togogenome.org/gene/9135:ZER1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MPZ0 ^@ Similarity ^@ Belongs to the zyg-11 family. http://togogenome.org/gene/9135:NRDE2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N113 ^@ Similarity ^@ Belongs to the NRDE2 family. http://togogenome.org/gene/9135:MTTP ^@ http://purl.uniprot.org/uniprot/A0A8C9NKV2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:NSFL1C ^@ http://purl.uniprot.org/uniprot/A0A8C9NMN0 ^@ Subcellular Location Annotation ^@ Golgi stack http://togogenome.org/gene/9135:CIRBP ^@ http://purl.uniprot.org/uniprot/A0A8C9MT01|||http://purl.uniprot.org/uniprot/A0A8C9MV41 ^@ Subcellular Location Annotation ^@ Cytoplasm|||nucleoplasm http://togogenome.org/gene/9135:LOC103813291 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGC7 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9135:LOC103826245 ^@ http://purl.uniprot.org/uniprot/A0A8C9NFW6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:FAT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N4Q3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:TRPM7 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQG7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.|||Membrane http://togogenome.org/gene/9135:TMEM182 ^@ http://purl.uniprot.org/uniprot/A0A8C9U3E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM182 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:VPS37B ^@ http://purl.uniprot.org/uniprot/A0A8C9N4I1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/9135:SNX2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Endosome membrane|||Membrane|||lamellipodium http://togogenome.org/gene/9135:TLCD2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MWN4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:CTSD ^@ http://purl.uniprot.org/uniprot/A0A8C9MME9 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9135:GPR180 ^@ http://purl.uniprot.org/uniprot/A0A8C9NS13 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:FASN ^@ http://purl.uniprot.org/uniprot/A0A8C9NAN2 ^@ Function ^@ Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. http://togogenome.org/gene/9135:POLR3A ^@ http://purl.uniprot.org/uniprot/A0A8C9MH49 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9135:GPR87 ^@ http://purl.uniprot.org/uniprot/A0A8C9N0V1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:TBX3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMV9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9135:ARG2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NH99 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9135:EIPR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NC35 ^@ Similarity ^@ Belongs to the WD repeat EIPR1 family. http://togogenome.org/gene/9135:GPM6B ^@ http://purl.uniprot.org/uniprot/A0A8C9NEQ8|||http://purl.uniprot.org/uniprot/A0A8C9NJV3|||http://purl.uniprot.org/uniprot/A0A8C9UFT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9135:PDP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHS9 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9135:LYPLAL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MS54 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/9135:TLR4 ^@ http://purl.uniprot.org/uniprot/A0A8C9UAC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9135:MAML3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mastermind family.|||Nucleus speckle http://togogenome.org/gene/9135:CBLB ^@ http://purl.uniprot.org/uniprot/A0A8C9NQ77|||http://purl.uniprot.org/uniprot/A0A8C9NSK2 ^@ Domain|||Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.|||The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. http://togogenome.org/gene/9135:DHRS11 ^@ http://purl.uniprot.org/uniprot/A0A8C9N917 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9135:ASIC4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/9135:NLGN3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NVI1|||http://purl.uniprot.org/uniprot/A0A8C9NXQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:MC4R ^@ http://purl.uniprot.org/uniprot/A0A8C9MK11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). http://togogenome.org/gene/9135:SNRPA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N5N7 ^@ Similarity ^@ Belongs to the U2 small nuclear ribonucleoprotein A family. http://togogenome.org/gene/9135:MC3R ^@ http://purl.uniprot.org/uniprot/A0A8C9NP74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane http://togogenome.org/gene/9135:LOC103812980 ^@ http://purl.uniprot.org/uniprot/A0A8C9KU93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9135:GPR89B ^@ http://purl.uniprot.org/uniprot/A0A8C9NDL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Golgi pH regulator (TC 1.A.38) family.|||Membrane http://togogenome.org/gene/9135:ELOC ^@ http://purl.uniprot.org/uniprot/A0A8C9KUI0 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/9135:PRKCQ ^@ http://purl.uniprot.org/uniprot/A0A8C9NHI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/9135:SLC50A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NG04 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SWEET sugar transporter family.|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates sugar transport across membranes.|||Membrane http://togogenome.org/gene/9135:ZGPAT ^@ http://purl.uniprot.org/uniprot/A0A8C9NM12 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:RAB3GAP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N6J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab3-GAP catalytic subunit family.|||Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/9135:PTPRF ^@ http://purl.uniprot.org/uniprot/A0A8C9L1G2 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. http://togogenome.org/gene/9135:UPK1B ^@ http://purl.uniprot.org/uniprot/A0A8C9N551 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9135:STX11 ^@ http://purl.uniprot.org/uniprot/A0A8C9U2N1 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9135:CPO ^@ http://purl.uniprot.org/uniprot/A0A8C9MFT0 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9135:SERPINF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MWY0 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9135:TM9SF3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MDP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9135:SULT1C4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIF5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9135:LOC103813169 ^@ http://purl.uniprot.org/uniprot/A0A8C9KXD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/9135:THPO ^@ http://purl.uniprot.org/uniprot/A0A8C9NJ48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EPO/TPO family.|||Secreted http://togogenome.org/gene/9135:ATE1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJZ4 ^@ Function|||Similarity ^@ Belongs to the R-transferase family.|||Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. http://togogenome.org/gene/9135:SLC39A9 ^@ http://purl.uniprot.org/uniprot/A0A8C9NE94 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Cell membrane|||Membrane|||Mitochondrion|||Nucleus|||Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.|||perinuclear region|||trans-Golgi network membrane http://togogenome.org/gene/9135:POLR3B ^@ http://purl.uniprot.org/uniprot/A0A8C9MIR7 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/9135:LOC103818471 ^@ http://purl.uniprot.org/uniprot/A0A8C9MI31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/9135:SULF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NSW6 ^@ Cofactor|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Binds 1 Ca(2+) ion per subunit.|||Cell surface|||Endoplasmic reticulum|||Golgi stack|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9135:LOC103819060 ^@ http://purl.uniprot.org/uniprot/A0A8C9UDG2 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/9135:PRPF38B ^@ http://purl.uniprot.org/uniprot/A0A8C9NCG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||May be required for pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/9135:TMEM50B ^@ http://purl.uniprot.org/uniprot/A0A8C9MNV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/9135:EGFL7 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIT3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:ANXA13 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVY8 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9135:ACMSD ^@ http://purl.uniprot.org/uniprot/A0A8C9N9F4|||http://purl.uniprot.org/uniprot/A0A8C9NAZ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.|||Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.|||Monomer. http://togogenome.org/gene/9135:ABL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MML1|||http://purl.uniprot.org/uniprot/A0A8C9U6R8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9135:PLPP5 ^@ http://purl.uniprot.org/uniprot/A0A8C9UIT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9135:SPOUT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MPF2 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. http://togogenome.org/gene/9135:LOC103812646 ^@ http://purl.uniprot.org/uniprot/A0A8C9MH53 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9135:VCAN ^@ http://purl.uniprot.org/uniprot/A0A8C9MZN5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9135:C1GALT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NFX7|||http://purl.uniprot.org/uniprot/A0A8C9NHH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.|||Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.|||Membrane http://togogenome.org/gene/9135:FTH1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N3P7 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/9135:TRMT13 ^@ http://purl.uniprot.org/uniprot/A0A8C9NEJ1 ^@ Function|||Similarity ^@ Belongs to the methyltransferase TRM13 family.|||tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). http://togogenome.org/gene/9135:CALHM2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NTA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9135:REEP3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/9135:CCNI ^@ http://purl.uniprot.org/uniprot/A0A8C9MM32 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9135:LARS2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFG7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9135:CHPF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UDF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9135:LOC103812987 ^@ http://purl.uniprot.org/uniprot/A0A8C9MF92 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:LOC103820550 ^@ http://purl.uniprot.org/uniprot/A0A8C9NC45 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:OCIAD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MXB7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OCIAD1 family.|||Endosome|||Interacts with STAT3.|||Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.|||The OCIA domain is necessary and sufficient for endosomal localization. http://togogenome.org/gene/9135:ADCY9 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGF7 ^@ Similarity ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. http://togogenome.org/gene/9135:EPC2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/9135:EMX2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGW9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:RNASEH1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NEW2 ^@ Function|||Similarity ^@ Belongs to the RNase H family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. http://togogenome.org/gene/9135:CCDC85A ^@ http://purl.uniprot.org/uniprot/A0A8C9UGR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC85 family.|||adherens junction http://togogenome.org/gene/9135:MAPK1IP1L ^@ http://purl.uniprot.org/uniprot/A0A8C9MFS6 ^@ Similarity ^@ Belongs to the MISS family. http://togogenome.org/gene/9135:LOC103824742 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selenium-binding protein family.|||Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.|||Membrane|||Nucleus|||cytosol http://togogenome.org/gene/9135:TNFRSF1A ^@ http://purl.uniprot.org/uniprot/A0A8C9UDZ9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:SRP19 ^@ http://purl.uniprot.org/uniprot/A0A8C9NV79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP19 family.|||Cytoplasm http://togogenome.org/gene/9135:STAT3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MV58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:ADGRF5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NLI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/9135:EVA1A ^@ http://purl.uniprot.org/uniprot/A0A8C9NLB1 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/9135:RCAN2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NLB8 ^@ Function|||Similarity ^@ Belongs to the RCAN family.|||Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. http://togogenome.org/gene/9135:TNFSF8 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUQ9 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9135:LSM8 ^@ http://purl.uniprot.org/uniprot/A0A8C9KTH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. http://togogenome.org/gene/9135:RFTN2 ^@ http://purl.uniprot.org/uniprot/A0A8C9U4F2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:GPR18 ^@ http://purl.uniprot.org/uniprot/A0A8C9NR26 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:TMTC4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NTK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9135:DHRS7B ^@ http://purl.uniprot.org/uniprot/A0A8C9N2N9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9135:CGA ^@ http://purl.uniprot.org/uniprot/A0A8C9MJ41 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Heterodimer of an alpha and a beta chain.|||Secreted http://togogenome.org/gene/9135:CAP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9KQS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAP family.|||Cell membrane http://togogenome.org/gene/9135:LOC103816959 ^@ http://purl.uniprot.org/uniprot/A0A8C9KTQ0 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:NKD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MN18 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NKD family.|||Cell autonomous antagonist of the canonical Wnt signaling pathway.|||Cell membrane|||Cytoplasm http://togogenome.org/gene/9135:LOC103820010 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIP1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.|||Membrane http://togogenome.org/gene/9135:LOC103817482 ^@ http://purl.uniprot.org/uniprot/A0A8C9NEQ0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9135:DRAM2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UB06 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:GALR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9135:NSMCE4A ^@ http://purl.uniprot.org/uniprot/A0A8C9NL44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE4 family.|||Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.|||Component of the SMC5-SMC6 complex.|||Nucleus|||telomere http://togogenome.org/gene/9135:TRAPPC2L ^@ http://purl.uniprot.org/uniprot/A0A8C9MVF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/9135:ACTL6A ^@ http://purl.uniprot.org/uniprot/A0A8C9NFE7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9135:IMPA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MG64 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9135:LOC103822543 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDC2|||http://purl.uniprot.org/uniprot/A0A8C9UFG8 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9135:SGK3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NLI9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/9135:FOXJ2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMS5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:LOC103815752 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCT9|||http://purl.uniprot.org/uniprot/A0A8C9UE84 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/9135:SLC22A18 ^@ http://purl.uniprot.org/uniprot/A0A8C9MP29 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:UPP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRE5 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. http://togogenome.org/gene/9135:SEC22C ^@ http://purl.uniprot.org/uniprot/A0A8C9MTB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/9135:RPL31 ^@ http://purl.uniprot.org/uniprot/A0A8C9KTP4 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL31 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9135:LOC103820785 ^@ http://purl.uniprot.org/uniprot/A0A8C9NV92 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/9135:CNDP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MXT4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9135:FGFR1OP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UCW4 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/9135:CASP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQY3 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9135:LOC103813345 ^@ http://purl.uniprot.org/uniprot/A0A8C9UBC1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9135:CEP57 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKJ1 ^@ Similarity ^@ Belongs to the translokin family. http://togogenome.org/gene/9135:OCRL ^@ http://purl.uniprot.org/uniprot/A0A8C9NMB1|||http://purl.uniprot.org/uniprot/A0A8C9NU76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.|||Early endosome membrane|||Endosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/9135:IWS1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MI39|||http://purl.uniprot.org/uniprot/A0A8C9U3I9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:MIGA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NLX8 ^@ Similarity ^@ Belongs to the mitoguardin family. http://togogenome.org/gene/9135:MRPS36 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVD9 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9135:LOC103817416 ^@ http://purl.uniprot.org/uniprot/A0A8C9N240 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:GPR158 ^@ http://purl.uniprot.org/uniprot/A0A8C9N5I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9135:MAP3K8 ^@ http://purl.uniprot.org/uniprot/A0A8C9N3D0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/9135:LOC103814676 ^@ http://purl.uniprot.org/uniprot/A0A8C9NL13 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9135:UPF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UDM2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9135:PTAFR ^@ http://purl.uniprot.org/uniprot/A0A8C9NP69 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ARRB1.|||Membrane http://togogenome.org/gene/9135:HJV ^@ http://purl.uniprot.org/uniprot/A0A8C9NDA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:S1PR3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:LOC103820479 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUE2 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9135:ULK3 ^@ http://purl.uniprot.org/uniprot/A0A8C9UFQ4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:LOC103818208 ^@ http://purl.uniprot.org/uniprot/A0A8C9KW39 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P2X receptor family.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9135:GDNF ^@ http://purl.uniprot.org/uniprot/A0A8C9MYE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/9135:AP1M1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQW7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Golgi apparatus|||Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9135:RPN2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDK2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SWP1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9135:MDFIC ^@ http://purl.uniprot.org/uniprot/A0A8C9N4U9 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/9135:DDC ^@ http://purl.uniprot.org/uniprot/A0A8C9MRP7 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9135:CD40LG ^@ http://purl.uniprot.org/uniprot/A0A8C9MKF7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.|||Belongs to the tumor necrosis factor family.|||Cell surface http://togogenome.org/gene/9135:ASPH ^@ http://purl.uniprot.org/uniprot/A0A8C9NLW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartyl/asparaginyl beta-hydroxylase family.|||Membrane http://togogenome.org/gene/9135:LIMK2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MK39|||http://purl.uniprot.org/uniprot/A0A8C9MKG9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/9135:HEBP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MV32 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/9135:EPB42 ^@ http://purl.uniprot.org/uniprot/A0A8C9UFX8 ^@ Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family. http://togogenome.org/gene/9135:NCOA2 ^@ http://purl.uniprot.org/uniprot/A0A8C9KTI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/9135:DR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJ77 ^@ Similarity ^@ Belongs to the NC2 beta/DR1 family. http://togogenome.org/gene/9135:SGCB ^@ http://purl.uniprot.org/uniprot/A0A8C9MYP8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.|||Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9135:TIMM9 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRB2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9135:CPAMD8 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/9135:STX3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N584|||http://purl.uniprot.org/uniprot/A0A8C9N5T5|||http://purl.uniprot.org/uniprot/A0A8C9N6U7 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9135:BUD31 ^@ http://purl.uniprot.org/uniprot/A0A8C9UCN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/9135:PCID2 ^@ http://purl.uniprot.org/uniprot/A0A8C9U855 ^@ Similarity ^@ Belongs to the CSN12 family. http://togogenome.org/gene/9135:ATOH7 ^@ http://purl.uniprot.org/uniprot/A0A8C9UEY2 ^@ Subcellular Location Annotation ^@ Nucleus|||Perikaryon|||axon http://togogenome.org/gene/9135:PROKR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MY30 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:FAM221A ^@ http://purl.uniprot.org/uniprot/A0A8C9NQA8 ^@ Similarity ^@ Belongs to the FAM221 family. http://togogenome.org/gene/9135:SLC39A10 ^@ http://purl.uniprot.org/uniprot/A0A8C9MI11 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:API5 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJL3 ^@ Similarity ^@ Belongs to the API5 family. http://togogenome.org/gene/9135:P2RX5 ^@ http://purl.uniprot.org/uniprot/A0A8C9N5K6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9135:ABCD2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MPY8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:TSPAN8 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9135:MAK16 ^@ http://purl.uniprot.org/uniprot/A0A8C9NB35 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/9135:PDPR ^@ http://purl.uniprot.org/uniprot/A0A8C9MRL0 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/9135:LOC103814915 ^@ http://purl.uniprot.org/uniprot/A0A8C9NN96 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/9135:ACAA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVS6 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9135:TMOD2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MNS3 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9135:TBXA2R ^@ http://purl.uniprot.org/uniprot/A0A8C9L2G8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9135:FGD4 ^@ http://purl.uniprot.org/uniprot/A0A8C9N3U8 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9135:LOC103815789 ^@ http://purl.uniprot.org/uniprot/A0A8C9NE69 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9135:POLR1A ^@ http://purl.uniprot.org/uniprot/A0A8C9NLP5 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/9135:IST1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UCR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IST1 family.|||Cytoplasmic vesicle|||Nucleus envelope http://togogenome.org/gene/9135:IREB2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UF70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Cytoplasm http://togogenome.org/gene/9135:MEOX1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVW1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:AGPAT5 ^@ http://purl.uniprot.org/uniprot/A0A8C9UEV1 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9135:SDR16C5 ^@ http://purl.uniprot.org/uniprot/A0A8C9UFW7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9135:NDUFB4 ^@ http://purl.uniprot.org/uniprot/A0A8C9N615 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB4 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9135:TM2D3 ^@ http://purl.uniprot.org/uniprot/A0A8C9UIF9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:CCDC85C ^@ http://purl.uniprot.org/uniprot/A0A8C9MWF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC85 family.|||adherens junction http://togogenome.org/gene/9135:AIDA ^@ http://purl.uniprot.org/uniprot/A0A8C9MYN6 ^@ Similarity ^@ Belongs to the AIDA family. http://togogenome.org/gene/9135:TRDMT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N9E9 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/9135:SDHA ^@ http://purl.uniprot.org/uniprot/A0A8C9MT28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.|||Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/9135:CSNK2A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMI1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:TEKT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NIV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||flagellum http://togogenome.org/gene/9135:SNX33 ^@ http://purl.uniprot.org/uniprot/A0A8C9NIA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/9135:POLB ^@ http://purl.uniprot.org/uniprot/A0A8C9NTC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Cytoplasm|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/9135:LOC103823905 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1H3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9135:LOC103818219 ^@ http://purl.uniprot.org/uniprot/A0A8C9KTU6 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9135:GCNT4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MNY6 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9135:CIAPIN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTY1 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion intermembrane space|||Monomer. Interacts with NDOR1. Interacts with CHCHD4.|||Nucleus|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/9135:F7 ^@ http://purl.uniprot.org/uniprot/A0A8C9MM07 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9135:PPA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UHK9 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/9135:LOC103824329 ^@ http://purl.uniprot.org/uniprot/A0A8C9NYV9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selectin/LECAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:PTPN12 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZE5|||http://purl.uniprot.org/uniprot/A0A8C9MZK0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.|||Cytoplasm|||Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. http://togogenome.org/gene/9135:TMLHE ^@ http://purl.uniprot.org/uniprot/A0A8C9NUJ2 ^@ Similarity ^@ Belongs to the gamma-BBH/TMLD family. http://togogenome.org/gene/9135:IL1B ^@ http://purl.uniprot.org/uniprot/A0A8C9NPB7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||Monomer.|||Secreted http://togogenome.org/gene/9135:LOC103813448 ^@ http://purl.uniprot.org/uniprot/A0A8C9N3I1 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9135:SIRT4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLJ9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sirtuin family. Class II subfamily.|||Binds 1 zinc ion per subunit.|||Mitochondrion matrix|||NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. http://togogenome.org/gene/9135:SLC6A6 ^@ http://purl.uniprot.org/uniprot/A0A8C9MNZ3|||http://purl.uniprot.org/uniprot/A0A8C9MP89|||http://purl.uniprot.org/uniprot/A0A8C9MPS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:TSPAN3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NHE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9135:CCDC34 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZQ6 ^@ Subcellular Location Annotation ^@ flagellum http://togogenome.org/gene/9135:ZDHHC21 ^@ http://purl.uniprot.org/uniprot/A0A8C9L3D5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9135:CD28 ^@ http://purl.uniprot.org/uniprot/A0A8C9KX70 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:SST ^@ http://purl.uniprot.org/uniprot/A0A8C9NLJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/9135:FBLN5 ^@ http://purl.uniprot.org/uniprot/A0A8C9N0L4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:PRIMPOL ^@ http://purl.uniprot.org/uniprot/A0A8C9N3J9 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/9135:RPS24 ^@ http://purl.uniprot.org/uniprot/A0A8C9MH29|||http://purl.uniprot.org/uniprot/A0A8C9MH98 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/9135:ATP7A ^@ http://purl.uniprot.org/uniprot/A0A8C9UHQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9135:LOC103814334 ^@ http://purl.uniprot.org/uniprot/A0A8C9NH24 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9135:LOC103820451 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9135:LOC103819062 ^@ http://purl.uniprot.org/uniprot/A0A8C9N772 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9135:CPEB1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQV3|||http://purl.uniprot.org/uniprot/A0A8C9NRK6 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/9135:RBFOX2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLD8 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||RNA-binding protein that regulates alternative splicing events. http://togogenome.org/gene/9135:CLIC5 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGA7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9135:LOC103821673 ^@ http://purl.uniprot.org/uniprot/A0A8C9UE25 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/9135:SPICE1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NBU5 ^@ Subcellular Location Annotation ^@ centriole|||spindle http://togogenome.org/gene/9135:RAD51D ^@ http://purl.uniprot.org/uniprot/A0A8C9UAA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Nucleus http://togogenome.org/gene/9135:LOC103819895 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJ49 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/9135:SEC11A ^@ http://purl.uniprot.org/uniprot/A0A8C9UHS6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:CA6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NTJ6 ^@ Caution|||Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9135:SLC25A30 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9135:CA10 ^@ http://purl.uniprot.org/uniprot/A0A8C9NL91 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Does not have a catalytic activity. http://togogenome.org/gene/9135:HOXA5 ^@ http://purl.uniprot.org/uniprot/A0A8C9UHE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9135:ALDH9A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFE5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9135:PGLYRP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKB0 ^@ Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. http://togogenome.org/gene/9135:TH ^@ http://purl.uniprot.org/uniprot/A0A8C9U8B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.|||axon|||perinuclear region http://togogenome.org/gene/9135:LOC103813280 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGA9 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9135:MRPS10 ^@ http://purl.uniprot.org/uniprot/A0A8C9MU20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS10 family.|||Mitochondrion http://togogenome.org/gene/9135:GTF2H2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTF2H2 family.|||Nucleus http://togogenome.org/gene/9135:AS3MT ^@ http://purl.uniprot.org/uniprot/A0A8C9NST9 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Arsenite methyltransferase family. http://togogenome.org/gene/9135:SV2B ^@ http://purl.uniprot.org/uniprot/A0A8C9MUC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9135:GPN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II.|||Cytoplasm|||Nucleus|||Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/9135:YWHAH ^@ http://purl.uniprot.org/uniprot/A0A8C9MK73 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9135:ELP4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MX94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP4 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:KIF15 ^@ http://purl.uniprot.org/uniprot/A0A8C9KUJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-12 subfamily.|||spindle http://togogenome.org/gene/9135:SFXN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KTX8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9135:CEPT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MWP9|||http://purl.uniprot.org/uniprot/A0A8C9MWU4 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/9135:LOC103818791 ^@ http://purl.uniprot.org/uniprot/A0A8C9NEZ7 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/9135:PDRG1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NLE8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.|||Cytoplasm|||May play a role in chaperone-mediated protein folding. http://togogenome.org/gene/9135:SLC35E2B ^@ http://purl.uniprot.org/uniprot/A0A8C9NRW0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:TMEM138 ^@ http://purl.uniprot.org/uniprot/A0A8C9N5S0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM138 family.|||Membrane|||Required for ciliogenesis.|||Vacuole membrane|||cilium http://togogenome.org/gene/9135:SPTBN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKS3 ^@ Similarity ^@ Belongs to the spectrin family. http://togogenome.org/gene/9135:UPF3B ^@ http://purl.uniprot.org/uniprot/A0A8C9NXM9 ^@ Similarity ^@ Belongs to the RENT3 family. http://togogenome.org/gene/9135:RPL23A ^@ http://purl.uniprot.org/uniprot/A0A8C9MYZ0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/9135:BMPR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MG31 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. http://togogenome.org/gene/9135:ATAD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKU3 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9135:LMNA ^@ http://purl.uniprot.org/uniprot/A0A8C9NJ72 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9135:CDH5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NA85 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/9135:LZTFL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFW7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LZTFL1 family.|||Cytoplasm|||Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.|||Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking. http://togogenome.org/gene/9135:VCAM1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NEI2 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9135:EXOC7 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHD4|||http://purl.uniprot.org/uniprot/A0A8C9MHH0|||http://purl.uniprot.org/uniprot/A0A8C9MHL0|||http://purl.uniprot.org/uniprot/A0A8C9MHM9 ^@ Function|||Similarity ^@ Belongs to the EXO70 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9135:PDE5A ^@ http://purl.uniprot.org/uniprot/A0A8C9KYA9 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9135:LOC103816605 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLS6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:LOC103822566 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CITED family.|||Nucleus http://togogenome.org/gene/9135:NSDHL ^@ http://purl.uniprot.org/uniprot/A0A8C9NTM8 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9135:TNFRSF25 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGN9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:GFRA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMJ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.|||Belongs to the GDNFR family.|||Cell membrane|||Membrane|||Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. http://togogenome.org/gene/9135:TNFRSF11A ^@ http://purl.uniprot.org/uniprot/A0A8C9MJA8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:NR1H3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9135:RAF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAW0|||http://purl.uniprot.org/uniprot/A0A8C9NB32 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/9135:LOC103819996 ^@ http://purl.uniprot.org/uniprot/A0A8C9MEB7 ^@ Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Interacts with NCDN.|||Membrane http://togogenome.org/gene/9135:LOC103822945 ^@ http://purl.uniprot.org/uniprot/A0A8C9U7Y1 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/9135:CP ^@ http://purl.uniprot.org/uniprot/A0A8C9N127 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9135:TRPV1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UE57 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:A4GALT ^@ http://purl.uniprot.org/uniprot/A0A8C9N324 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 32 family.|||Golgi apparatus membrane http://togogenome.org/gene/9135:MFN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NFQ7 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9135:LMOD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MXM3 ^@ Subcellular Location Annotation ^@ cytoskeleton|||sarcomere http://togogenome.org/gene/9135:SLC17A5 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYS2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:EMG1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMF6 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. http://togogenome.org/gene/9135:IL10 ^@ http://purl.uniprot.org/uniprot/A0A8C9UFB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9135:EPHA7 ^@ http://purl.uniprot.org/uniprot/A0A8C9L3C8|||http://purl.uniprot.org/uniprot/A0A8C9MF79 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:NTAQ1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MWY1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NTAQ1 family.|||Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.|||Monomer. http://togogenome.org/gene/9135:A2M ^@ http://purl.uniprot.org/uniprot/A0A8C9KP39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/9135:LOC103814146 ^@ http://purl.uniprot.org/uniprot/A0A8C9NVN0 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/9135:MED22 ^@ http://purl.uniprot.org/uniprot/A0A8C9MK89 ^@ Function|||Subcellular Location Annotation ^@ Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9135:LOC103815260 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFZ4 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9135:SMIM18 ^@ http://purl.uniprot.org/uniprot/A0A8C9U6A4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:FITM2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NHJ3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:APOD ^@ http://purl.uniprot.org/uniprot/A0A8C9NS99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9135:PDE6B ^@ http://purl.uniprot.org/uniprot/A0A8C9UFK3 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9135:AP3D1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFF5 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9135:GFOD2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MT22 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/9135:TUBB1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NS11 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9135:PDX1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTI6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:NR1H4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUG3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.|||Nucleus http://togogenome.org/gene/9135:PKIA ^@ http://purl.uniprot.org/uniprot/A0A8C9MFM4 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9135:ARMC9 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMN2|||http://purl.uniprot.org/uniprot/A0A8C9NNK9 ^@ Subcellular Location Annotation ^@ centriole|||cilium|||cilium basal body http://togogenome.org/gene/9135:GSX1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MV57 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:ATOSA ^@ http://purl.uniprot.org/uniprot/A0A8C9L1J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATOS family.|||Nucleus http://togogenome.org/gene/9135:CMC2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/9135:MYO1E ^@ http://purl.uniprot.org/uniprot/A0A8C9NW41 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9135:GALNT3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NNY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9135:HSPB2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZP6 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/9135:DLL4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MG65 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/9135:LOC103817611 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:PRICKLE2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVF7|||http://purl.uniprot.org/uniprot/A0A8C9UC21 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/9135:GJA5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9135:GATM ^@ http://purl.uniprot.org/uniprot/A0A8C9MPG7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the amidinotransferase family.|||Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development.|||Homodimer.|||Mitochondrion inner membrane http://togogenome.org/gene/9135:NDP ^@ http://purl.uniprot.org/uniprot/A0A8C9NAV8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9135:ABCB9 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2K9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:TSEN15 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAN0 ^@ Similarity ^@ Belongs to the SEN15 family. http://togogenome.org/gene/9135:SERPINB10 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFK2 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9135:TVP23A ^@ http://purl.uniprot.org/uniprot/A0A8C9UEK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/9135:SLC35A5 ^@ http://purl.uniprot.org/uniprot/A0A8C9N476 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9135:FERMT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGB4 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/9135:QRFPR ^@ http://purl.uniprot.org/uniprot/A0A8C9KYY6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:RBBP8 ^@ http://purl.uniprot.org/uniprot/A0A8C9N7X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COM1/SAE2/CtIP family.|||Nucleus http://togogenome.org/gene/9135:CRYAA ^@ http://purl.uniprot.org/uniprot/A0A8C9NAS2 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/9135:CLRN2 ^@ http://purl.uniprot.org/uniprot/A0A8C9L651 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9135:GSTA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NBA1 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9135:MRPS7 ^@ http://purl.uniprot.org/uniprot/A0A8C9KUT2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/9135:RNF13 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1L3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:GALNT15 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPY9|||http://purl.uniprot.org/uniprot/A0A8C9NQZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9135:EEF1A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UCA9 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/9135:NUDT12 ^@ http://purl.uniprot.org/uniprot/A0A8C9UJ09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Nudix hydrolase family. NudC subfamily.|||Cytoplasmic granule|||Peroxisome http://togogenome.org/gene/9135:NCBP3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVT3 ^@ Similarity ^@ Belongs to the NCBP3 family. http://togogenome.org/gene/9135:LPAR4 ^@ http://purl.uniprot.org/uniprot/A0A8C9KUN2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:DRD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UH54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:TACC2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJJ2|||http://purl.uniprot.org/uniprot/A0A8C9UGI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACC family.|||Cytoplasm http://togogenome.org/gene/9135:PDCD5 ^@ http://purl.uniprot.org/uniprot/A0A8C9ML33 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/9135:ING5 ^@ http://purl.uniprot.org/uniprot/A0A8C9N0W5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9135:LOC103827082 ^@ http://purl.uniprot.org/uniprot/A0A8C9N4H4 ^@ Function|||Similarity ^@ Belongs to the apovitellenin family.|||Protein component of the very low density lipoprotein (VLDL) of egg-laying females. Potent lipoprotein lipase inhibitor, preventing the loss of triglycerides from VLDL on their way from the liver to the growing oocytes. http://togogenome.org/gene/9135:TRAPPC3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NP10 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/9135:LOC103813349 ^@ http://purl.uniprot.org/uniprot/A0A8C9UBC1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9135:SLC45A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MH31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:ALX1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZF8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:LOC103813337 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUQ2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9135:RBM47 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM RBM47 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:NAALADL2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCI1|||http://purl.uniprot.org/uniprot/A0A8C9NE58|||http://purl.uniprot.org/uniprot/A0A8C9NF36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Membrane http://togogenome.org/gene/9135:LOC103815742 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAE4 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/9135:LOC103820475 ^@ http://purl.uniprot.org/uniprot/A0A8C9U9G2 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9135:TRAPPC6B ^@ http://purl.uniprot.org/uniprot/A0A8C9N504 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/9135:AGPAT3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NBM7 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9135:HSDL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MPY0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9135:DCT ^@ http://purl.uniprot.org/uniprot/A0A8C9NTR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane|||Membrane http://togogenome.org/gene/9135:HOXA6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NR95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9135:PDE8A ^@ http://purl.uniprot.org/uniprot/A0A8C9U869 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9135:SCG5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 7B2 family.|||Secreted http://togogenome.org/gene/9135:MTNR1A ^@ http://purl.uniprot.org/uniprot/A0A8C9N6V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:NSRP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2L8 ^@ Similarity ^@ Belongs to the NSRP1 family. http://togogenome.org/gene/9135:C2H5orf22 ^@ http://purl.uniprot.org/uniprot/A0A8C9U549 ^@ Similarity ^@ Belongs to the UPF0489 family. http://togogenome.org/gene/9135:NUF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFH9 ^@ Similarity ^@ Belongs to the NUF2 family. http://togogenome.org/gene/9135:PHTF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UCI3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:NAPB ^@ http://purl.uniprot.org/uniprot/A0A8C9NNZ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9135:LOC103827237 ^@ http://purl.uniprot.org/uniprot/A0A8C9U1H4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:PIK3R3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHV2 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/9135:STON1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NFM1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Stoned B family.|||Cytoplasm|||May be involved in the endocytic machinery. http://togogenome.org/gene/9135:ITM2B ^@ http://purl.uniprot.org/uniprot/A0A8C9UG42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/9135:FRRS1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NHB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FRRS1 family.|||Membrane http://togogenome.org/gene/9135:YPEL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMK0 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9135:AP1S3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||clathrin-coated pit http://togogenome.org/gene/9135:RPL9 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRX5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/9135:ISM2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N3X4 ^@ Similarity ^@ Belongs to the isthmin family. http://togogenome.org/gene/9135:EHHADH ^@ http://purl.uniprot.org/uniprot/A0A8C9MQV8 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9135:YTHDC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDE1|||http://purl.uniprot.org/uniprot/A0A8C9NHH4 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/9135:SGPL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NU65 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/9135:KCNK5 ^@ http://purl.uniprot.org/uniprot/A0A8C9N958 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9135:LOC103821826 ^@ http://purl.uniprot.org/uniprot/A0A8C9N9M4 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/9135:OSBPL10 ^@ http://purl.uniprot.org/uniprot/A0A8C9MDR6 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9135:EXOSC2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP4 family.|||Cytoplasm http://togogenome.org/gene/9135:PI4KA ^@ http://purl.uniprot.org/uniprot/A0A8C9MN23 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9135:CHRM5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NBR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/9135:GHSR ^@ http://purl.uniprot.org/uniprot/A0A8C9UES7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:LOC103827252 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:DCAF13 ^@ http://purl.uniprot.org/uniprot/A0A8C9MS41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DCAF13/WDSOF1 family.|||nucleolus http://togogenome.org/gene/9135:CAPZA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPM6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/9135:GOSR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1Z6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GOSR1 family.|||Component of several multiprotein Golgi SNARE complexes.|||Golgi apparatus membrane|||Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.|||Membrane http://togogenome.org/gene/9135:YIPF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Endosome membrane|||Golgi apparatus membrane|||Late endosome membrane|||Membrane|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/9135:LOC103821740 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Secreted http://togogenome.org/gene/9135:SLC25A38 ^@ http://purl.uniprot.org/uniprot/A0A8C9L6H9|||http://purl.uniprot.org/uniprot/A0A8C9MF93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.|||Membrane|||Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/9135:FAM210A ^@ http://purl.uniprot.org/uniprot/A0A8C9MZD3 ^@ Similarity ^@ Belongs to the LEA type 4 family. http://togogenome.org/gene/9135:NOP14 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP14 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.|||nucleolus http://togogenome.org/gene/9135:MAS1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UES2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:LITAF ^@ http://purl.uniprot.org/uniprot/A0A8C9UEJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/9135:LOC103821610 ^@ http://purl.uniprot.org/uniprot/A0A8C9MWU1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9135:TAC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NH33|||http://purl.uniprot.org/uniprot/A0A8C9NJA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted|||Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. http://togogenome.org/gene/9135:EVA1C ^@ http://purl.uniprot.org/uniprot/A0A8C9N346 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/9135:UTP15 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMV6 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9135:ADGRG6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NL42 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:PTPN21 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/9135:RBP7 ^@ http://purl.uniprot.org/uniprot/A0A8C9NY26 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9135:LOC103826086 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQ14 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9135:CLPS ^@ http://purl.uniprot.org/uniprot/A0A8C9NLS9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.|||Enterostatin has a biological activity as a satiety signal.|||Forms a 1:1 stoichiometric complex with pancreatic lipase.|||Secreted http://togogenome.org/gene/9135:PTGR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NK55 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9135:FGD2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NF04 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9135:SLCO1C1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYD6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:C1H11orf54 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJR7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.|||Monomer.|||Nucleus http://togogenome.org/gene/9135:NT5C3A ^@ http://purl.uniprot.org/uniprot/A0A8C9N6E4|||http://purl.uniprot.org/uniprot/A0A8C9N7J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/9135:CCT3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N9G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9135:MRPL41 ^@ http://purl.uniprot.org/uniprot/A0A8C9N7Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL41 family.|||Mitochondrion http://togogenome.org/gene/9135:LOC103817262 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAH6|||http://purl.uniprot.org/uniprot/A0A8C9NAP1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.|||Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. http://togogenome.org/gene/9135:TRPV3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N7Q6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:FLT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:SPCS2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS2 family.|||Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:PPFIBP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYJ5|||http://purl.uniprot.org/uniprot/A0A8C9MZX5|||http://purl.uniprot.org/uniprot/A0A8C9UCJ3 ^@ Similarity ^@ Belongs to the liprin family. Liprin-beta subfamily. http://togogenome.org/gene/9135:OPA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKR3 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/9135:LOC103822944 ^@ http://purl.uniprot.org/uniprot/A0A8C9MME5 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/9135:LBH ^@ http://purl.uniprot.org/uniprot/A0A8C9NRT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LBH family.|||Cytoplasm|||Nucleus|||Transcriptional activator. http://togogenome.org/gene/9135:FAM234A ^@ http://purl.uniprot.org/uniprot/A0A8C9UFE4 ^@ Similarity ^@ Belongs to the FAM234 family. http://togogenome.org/gene/9135:MFSD11 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/9135:METTL16 ^@ http://purl.uniprot.org/uniprot/A0A8C9N6I2 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METTL16/RlmF family.|||RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. http://togogenome.org/gene/9135:ADM ^@ http://purl.uniprot.org/uniprot/A0A8C9MZ35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adrenomedullin family.|||Secreted http://togogenome.org/gene/9135:RSAD2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RSAD2 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:CDKN1B ^@ http://purl.uniprot.org/uniprot/A0A8C9N5F0 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/9135:PRDX6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQQ2 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/9135:NUSAP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9U398 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NUSAP family.|||Cytoplasm http://togogenome.org/gene/9135:ACE ^@ http://purl.uniprot.org/uniprot/A0A8C9N255 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M2 family.|||Binds 2 Zn(2+) ions per subunit. http://togogenome.org/gene/9135:TRAF5 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9135:NEK7 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCC6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:LOC103820232 ^@ http://purl.uniprot.org/uniprot/A0A8C9U6J3 ^@ Function|||Similarity ^@ Belongs to the TYW1 family.|||Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis. http://togogenome.org/gene/9135:HTRA3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NNT6 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/9135:SLC16A12 ^@ http://purl.uniprot.org/uniprot/A0A8C9NY27 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:LOC103814830 ^@ http://purl.uniprot.org/uniprot/A0A8C9NA07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9135:SNRPC ^@ http://purl.uniprot.org/uniprot/A0A8C9NRR0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U1 small nuclear ribonucleoprotein C family.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Nucleus|||U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. http://togogenome.org/gene/9135:CERS3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1H7|||http://purl.uniprot.org/uniprot/A0A8C9N2G6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9135:OLFML3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NG25 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:ST3GAL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9135:SPI1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9135:NDUFB8 ^@ http://purl.uniprot.org/uniprot/A0A8C9NXZ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB8 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9135:ATG2B ^@ http://purl.uniprot.org/uniprot/A0A8C9UC51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG2 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Preautophagosomal structure membrane http://togogenome.org/gene/9135:PLA2G1B ^@ http://purl.uniprot.org/uniprot/A0A8C9MLQ2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9135:CDCP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTP7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:FGD6 ^@ http://purl.uniprot.org/uniprot/A0A8C9MX89 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9135:SOAT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N6G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:TRIP13 ^@ http://purl.uniprot.org/uniprot/A0A8C9UHD0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. PCH2 subfamily.|||Nucleus|||Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. http://togogenome.org/gene/9135:PRPF3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCQ7 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). http://togogenome.org/gene/9135:SLC30A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MT67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9135:AAMP ^@ http://purl.uniprot.org/uniprot/A0A8C9UFW5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:LOC103815768 ^@ http://purl.uniprot.org/uniprot/A0A8C9NC39 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/9135:GEM ^@ http://purl.uniprot.org/uniprot/A0A8C9MI79 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9135:HBS1L ^@ http://purl.uniprot.org/uniprot/A0A8C9NA56 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9135:PHACTR4 ^@ http://purl.uniprot.org/uniprot/A0A8C9UBY4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin.|||Cytoplasm|||Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.|||lamellipodium http://togogenome.org/gene/9135:MKI67 ^@ http://purl.uniprot.org/uniprot/A0A8C9UEB4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:ARL8A ^@ http://purl.uniprot.org/uniprot/A0A8C9MSR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/9135:ANKRD13A ^@ http://purl.uniprot.org/uniprot/A0A8C9MSG1 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/9135:CPD ^@ http://purl.uniprot.org/uniprot/A0A8C9N2A7 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9135:STAC ^@ http://purl.uniprot.org/uniprot/A0A8C9N671 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9135:CSNK1G3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQ66|||http://purl.uniprot.org/uniprot/A0A8C9U808 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/9135:MBP ^@ http://purl.uniprot.org/uniprot/A0A8C9MXZ6|||http://purl.uniprot.org/uniprot/A0A8C9MYK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin basic protein family.|||Myelin membrane http://togogenome.org/gene/9135:SEMA5A ^@ http://purl.uniprot.org/uniprot/A0A8C9MMF1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:MYOF ^@ http://purl.uniprot.org/uniprot/A0A8C9NXH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ferlin family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9135:DYNC2H1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKM2 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/9135:LOC103820946 ^@ http://purl.uniprot.org/uniprot/A0A8C9U2V4 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9135:PCSK2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MWI5|||http://purl.uniprot.org/uniprot/A0A8C9MZM5 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9135:LOC103826085 ^@ http://purl.uniprot.org/uniprot/A0A8C9NNV7 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9135:PGD ^@ http://purl.uniprot.org/uniprot/A0A8C9NXZ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 6-phosphogluconate dehydrogenase family.|||Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.|||Homodimer. http://togogenome.org/gene/9135:FABP6 ^@ http://purl.uniprot.org/uniprot/A0A8C9KTL7 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9135:OAT ^@ http://purl.uniprot.org/uniprot/A0A8C9UFV2 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9135:NDUFS5 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQA3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS5 subunit family.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9135:LCA5 ^@ http://purl.uniprot.org/uniprot/A0A8C9MN30 ^@ Similarity ^@ Belongs to the LCA5 family. http://togogenome.org/gene/9135:LOC103824423 ^@ http://purl.uniprot.org/uniprot/A0A8C9U905 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:EXT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UBS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9135:FGF23 ^@ http://purl.uniprot.org/uniprot/A0A8C9N5I5 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9135:DDO ^@ http://purl.uniprot.org/uniprot/A0A8C9L4P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/9135:MCM2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MP17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/9135:SGK2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NEP0|||http://purl.uniprot.org/uniprot/A0A8C9NF16 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:THUMPD2 ^@ http://purl.uniprot.org/uniprot/A0A8C9L4L7 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9135:RBP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N0Q9 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9135:EXTL3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9135:MID2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UI08 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9135:ALG14 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG14 family.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane http://togogenome.org/gene/9135:LOC103823654 ^@ http://purl.uniprot.org/uniprot/A0A8C9N828 ^@ Similarity ^@ Belongs to the CBP3 family. http://togogenome.org/gene/9135:INTS8 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 8 family.|||Nucleus http://togogenome.org/gene/9135:TIPIN ^@ http://purl.uniprot.org/uniprot/A0A8C9N9H4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSM3 family.|||Nucleus|||Plays an important role in the control of DNA replication and the maintenance of replication fork stability. http://togogenome.org/gene/9135:UROD ^@ http://purl.uniprot.org/uniprot/A0A8C9KRZ7 ^@ Similarity|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Homodimer. http://togogenome.org/gene/9135:FIGN ^@ http://purl.uniprot.org/uniprot/A0A8C9UHB8 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9135:DNAJB14 ^@ http://purl.uniprot.org/uniprot/A0A8C9NLD0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:RHO ^@ http://purl.uniprot.org/uniprot/A0A8C9NTZ8 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Contains one covalently linked retinal chromophore.|||Membrane http://togogenome.org/gene/9135:MITF ^@ http://purl.uniprot.org/uniprot/A0A8C9UBY8|||http://purl.uniprot.org/uniprot/A0A8C9UCI7|||http://purl.uniprot.org/uniprot/A0A8C9UCI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9135:MYOD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MPG0 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/9135:LOC103824734 ^@ http://purl.uniprot.org/uniprot/A0A8C9NT99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:PIK3CG ^@ http://purl.uniprot.org/uniprot/A0A8C9MWE7 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9135:LOC108961169 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZ61 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9135:PTS ^@ http://purl.uniprot.org/uniprot/A0A8C9UBP3 ^@ Function|||Similarity ^@ Belongs to the PTPS family.|||Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. http://togogenome.org/gene/9135:HOPX ^@ http://purl.uniprot.org/uniprot/A0A8C9NE66 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:VIM ^@ http://purl.uniprot.org/uniprot/A0A8C9UEG7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9135:LOC103819581 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1A2 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9135:MALL ^@ http://purl.uniprot.org/uniprot/A0A8C9NKC5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:C9H3orf70 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQJ9 ^@ Similarity ^@ Belongs to the UPF0524 family. http://togogenome.org/gene/9135:RGMB ^@ http://purl.uniprot.org/uniprot/A0A8C9UB84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:ALDOC ^@ http://purl.uniprot.org/uniprot/A0A8C9MXC9 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/9135:MAB21L1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCT2 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9135:LOC103812823 ^@ http://purl.uniprot.org/uniprot/A0A8C9NER4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9135:PSMD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NN88 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S1 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/9135:GGACT ^@ http://purl.uniprot.org/uniprot/A0A8C9NRF1 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family.|||Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. http://togogenome.org/gene/9135:BFSP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZN1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||cell cortex|||cytoskeleton http://togogenome.org/gene/9135:JPT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KUV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:C1S ^@ http://purl.uniprot.org/uniprot/A0A8C9NN97 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:MAPK1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MN39 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9135:IL7R ^@ http://purl.uniprot.org/uniprot/A0A8C9MZI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Membrane http://togogenome.org/gene/9135:DNASE1L3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKQ2 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/9135:LOC103812473 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9135:CMAS ^@ http://purl.uniprot.org/uniprot/A0A8C9N3Q3 ^@ Similarity ^@ Belongs to the CMP-NeuNAc synthase family. http://togogenome.org/gene/9135:SAMM50 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAM50/omp85 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9135:NUP133 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin Nup133 family.|||nuclear pore complex http://togogenome.org/gene/9135:PTGR3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MY45 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9135:RELL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9U9I9 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/9135:LOC103813931 ^@ http://purl.uniprot.org/uniprot/A0A8C9UIA7 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9135:LOC103826448 ^@ http://purl.uniprot.org/uniprot/A0A8C9MW60 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9135:LOC103817388 ^@ http://purl.uniprot.org/uniprot/A0A8C9L3S5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRQ/QCR8 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9135:KIF25 ^@ http://purl.uniprot.org/uniprot/A0A8C9U3Y0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9135:SLC6A14 ^@ http://purl.uniprot.org/uniprot/A0A8C9UIH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9135:ABCA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKD9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:NEUROD6 ^@ http://purl.uniprot.org/uniprot/A0A8C9N6C0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:DLGAP5 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFU2 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9135:SESN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9L1I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9135:LOC103813439 ^@ http://purl.uniprot.org/uniprot/A0A8C9UCK6 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/9135:L3HYPDH ^@ http://purl.uniprot.org/uniprot/A0A8C9MT58 ^@ Similarity ^@ Belongs to the proline racemase family. http://togogenome.org/gene/9135:LGI1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NVE2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9135:APIP ^@ http://purl.uniprot.org/uniprot/A0A8C9MK54 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aldolase class II family. Adducin subfamily.|||Belongs to the aldolase class II family. MtnB subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis.|||Cytoplasm http://togogenome.org/gene/9135:LOC103826869 ^@ http://purl.uniprot.org/uniprot/A0A8C9MV82 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/9135:PGAM1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRX6 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9135:DERL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MXY4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/9135:TBL1X ^@ http://purl.uniprot.org/uniprot/A0A8C9NG09|||http://purl.uniprot.org/uniprot/A0A8C9NHJ7 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/9135:TRPC4 ^@ http://purl.uniprot.org/uniprot/A0A8C9UFT4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:ZDHHC12 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQ74 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9135:RTF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NSG8 ^@ Similarity ^@ Belongs to the rtf2 family. http://togogenome.org/gene/9135:DLK2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCJ2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:LOC103813316 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGD6 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9135:ARHGEF3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MG03 ^@ Function|||Subcellular Location Annotation ^@ Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.|||Cytoplasm http://togogenome.org/gene/9135:TSPAN9 ^@ http://purl.uniprot.org/uniprot/A0A8C9UH05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9135:DSCC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MX56 ^@ Similarity ^@ Belongs to the DCC1 family. http://togogenome.org/gene/9135:LOC103816795 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKV9 ^@ Similarity ^@ Belongs to the BtpA family. http://togogenome.org/gene/9135:GNG7 ^@ http://purl.uniprot.org/uniprot/A0A8C9MXG3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9135:LOC103814993 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIJ3 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/9135:WNT10A ^@ http://purl.uniprot.org/uniprot/A0A8C9UFN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9135:TLL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8A8 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:ABCG1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NA09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9135:LOC103821128 ^@ http://purl.uniprot.org/uniprot/A0A8C9N641 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9135:CCK ^@ http://purl.uniprot.org/uniprot/A0A8C9L4D5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Secreted http://togogenome.org/gene/9135:MAPK9 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8J9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/9135:RPN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMN4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9135:CAMK1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MR74 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:TPRA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MND0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0359 family.|||Membrane http://togogenome.org/gene/9135:UBE2E2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQY1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9135:SLC10A2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NV12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9135:GPR171 ^@ http://purl.uniprot.org/uniprot/A0A8C9UD00 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:BCR ^@ http://purl.uniprot.org/uniprot/A0A8C9MK42|||http://purl.uniprot.org/uniprot/A0A8C9U6L7 ^@ Subcellular Location Annotation ^@ Synapse|||axon|||dendritic spine http://togogenome.org/gene/9135:TM7SF3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N5V2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:ID3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N197 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:ABCC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NC41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:STK38L ^@ http://purl.uniprot.org/uniprot/A0A8C9N4S9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:POLL ^@ http://purl.uniprot.org/uniprot/A0A8C9NT63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:CCNB3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NS03 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9135:BRCA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MU06 ^@ Subcellular Location Annotation ^@ Chromosome|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:P2RY13 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:SLC16A5 ^@ http://purl.uniprot.org/uniprot/A0A8C9KV98 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:KCNK9 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane|||pH-dependent, voltage-insensitive, background potassium channel protein. http://togogenome.org/gene/9135:ABCB1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NBQ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:MRPL15 ^@ http://purl.uniprot.org/uniprot/A0A8C9NG24 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/9135:CLDN23 ^@ http://purl.uniprot.org/uniprot/A0A8C9UEV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9135:LOC103824242 ^@ http://purl.uniprot.org/uniprot/A0A8C9NVN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tango11 family.|||Membrane|||Mitochondrion outer membrane|||Peroxisome|||Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. http://togogenome.org/gene/9135:TAT ^@ http://purl.uniprot.org/uniprot/A0A8C9N6L9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. http://togogenome.org/gene/9135:NHP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9L183 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/9135:HNF4A ^@ http://purl.uniprot.org/uniprot/A0A8C9UFY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9135:MLN ^@ http://purl.uniprot.org/uniprot/A0A8C9NQ26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the motilin family.|||Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.|||Secreted http://togogenome.org/gene/9135:P4HA2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8R1|||http://purl.uniprot.org/uniprot/A0A8C9UDY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9135:LOC103822464 ^@ http://purl.uniprot.org/uniprot/A0A8C9NE77 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9135:LOC103812310 ^@ http://purl.uniprot.org/uniprot/A0A8C9NVC3 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9135:HPSE ^@ http://purl.uniprot.org/uniprot/A0A8C9NKM6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/9135:LOC103817832 ^@ http://purl.uniprot.org/uniprot/A0A8C9MZJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/9135:LHFPL4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MPV1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:LOC103826968 ^@ http://purl.uniprot.org/uniprot/A0A8C9UG41 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9135:IL4I1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQW3 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/9135:LOC103813955 ^@ http://purl.uniprot.org/uniprot/A0A8C9NYD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/9135:EDEM2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1B8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9135:SERINC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NM80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9135:SAR1B ^@ http://purl.uniprot.org/uniprot/A0A8C9UE12 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/9135:WDR35 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJ09 ^@ Subcellular Location Annotation ^@ centrosome|||cilium basal body http://togogenome.org/gene/9135:LACTB2 ^@ http://purl.uniprot.org/uniprot/A0A8C9KY01 ^@ Function|||Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.|||Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability. http://togogenome.org/gene/9135:DLC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N3T8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9135:XDH ^@ http://purl.uniprot.org/uniprot/A0A8C9NP60 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Peroxisome http://togogenome.org/gene/9135:DLX5 ^@ http://purl.uniprot.org/uniprot/A0A8C9UG28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/9135:NUP93 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin interacting component (NIC) family.|||Nucleus membrane|||Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.|||nuclear pore complex http://togogenome.org/gene/9135:INTS14 ^@ http://purl.uniprot.org/uniprot/A0A8C9N7S3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INTS14 family.|||Nucleus|||Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. http://togogenome.org/gene/9135:LOC103827253 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:RPP14 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRE7 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family. http://togogenome.org/gene/9135:HPS5 ^@ http://purl.uniprot.org/uniprot/A0A8C9U929 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HPS5 family.|||Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.|||May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.|||cytosol http://togogenome.org/gene/9135:VPS36 ^@ http://purl.uniprot.org/uniprot/A0A8C9ND20 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS36 family.|||Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II).|||Cytoplasm|||Endosome http://togogenome.org/gene/9135:IL13RA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NYJ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:SH3BGRL ^@ http://purl.uniprot.org/uniprot/A0A8C9MGQ7 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/9135:TTC39C ^@ http://purl.uniprot.org/uniprot/A0A8C9NBJ3 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/9135:STMN3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NNK2 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9135:CAPN6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NSX7 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9135:DDI2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MNC1 ^@ Similarity ^@ Belongs to the DDI1 family. http://togogenome.org/gene/9135:GOSR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N3D2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOSR2 family.|||Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.|||Membrane http://togogenome.org/gene/9135:CXCR5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NXU0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:PDE6C ^@ http://purl.uniprot.org/uniprot/A0A8C9UIP1 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9135:ZNF706 ^@ http://purl.uniprot.org/uniprot/A0A8C9MML8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9135:WNT7B ^@ http://purl.uniprot.org/uniprot/A0A8C9MHR0|||http://purl.uniprot.org/uniprot/A0A8C9MI34 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9135:FAM3D ^@ http://purl.uniprot.org/uniprot/A0A8C9MUC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9135:RAB19 ^@ http://purl.uniprot.org/uniprot/A0A8C9UD62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane http://togogenome.org/gene/9135:EBF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NXN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/9135:LOC103819513 ^@ http://purl.uniprot.org/uniprot/A0A8C9KSC8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Has antiviral activities.|||Secreted http://togogenome.org/gene/9135:CEBPZ ^@ http://purl.uniprot.org/uniprot/A0A8C9N9V7 ^@ Similarity ^@ Belongs to the CBF/MAK21 family. http://togogenome.org/gene/9135:ZWILCH ^@ http://purl.uniprot.org/uniprot/A0A8C9N820 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZWILCH family.|||Component of the RZZ complex.|||Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.|||kinetochore http://togogenome.org/gene/9135:S1PR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:MPPE1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UCL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the metallophosphoesterase superfamily. MPPE1 family.|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.|||cis-Golgi network membrane http://togogenome.org/gene/9135:POLR3F ^@ http://purl.uniprot.org/uniprot/A0A8C9NDN8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9135:CASTOR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2W7 ^@ Similarity ^@ Belongs to the GATS family. http://togogenome.org/gene/9135:LOC103819907 ^@ http://purl.uniprot.org/uniprot/A0A8C9MK22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiA prenyltransferase family.|||Converts protoheme IX and farnesyl diphosphate to heme O.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9135:PRKCZ ^@ http://purl.uniprot.org/uniprot/A0A8C9UJ11 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. http://togogenome.org/gene/9135:CMC4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQL3|||http://purl.uniprot.org/uniprot/A0A8C9UI77 ^@ Similarity ^@ Belongs to the CMC4 family. http://togogenome.org/gene/9135:LOC103812472 ^@ http://purl.uniprot.org/uniprot/A0A8C9NM22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9135:DDOST ^@ http://purl.uniprot.org/uniprot/A0A8C9MMF9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DDOST 48 kDa subunit family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). http://togogenome.org/gene/9135:OPTN ^@ http://purl.uniprot.org/uniprot/A0A8C9N4X2 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Golgi apparatus|||May act by regulating membrane trafficking and cellular morphogenesis.|||Recycling endosome|||autophagosome|||perinuclear region|||trans-Golgi network http://togogenome.org/gene/9135:DNAJB12 ^@ http://purl.uniprot.org/uniprot/A0A8C9NSH8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:C9 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYX6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9135:MPG ^@ http://purl.uniprot.org/uniprot/A0A8C9UFB9 ^@ Function|||Similarity ^@ Belongs to the DNA glycosylase MPG family.|||Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. http://togogenome.org/gene/9135:SERPINF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUW1 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9135:TMPRSS6 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLL9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:KCNJ5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NY90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.|||Membrane http://togogenome.org/gene/9135:LOC103823464 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9135:LOC108962310 ^@ http://purl.uniprot.org/uniprot/A0A8C9N759 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9135:GPATCH11 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDR0 ^@ Similarity ^@ Belongs to the GPATCH11 family. http://togogenome.org/gene/9135:POPDC2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N5S1 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9135:GINS1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MEU9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS1/PSF1 family.|||Chromosome|||Component of the GINS complex.|||Nucleus|||Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. http://togogenome.org/gene/9135:CDS1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Membrane http://togogenome.org/gene/9135:LOC103816009 ^@ http://purl.uniprot.org/uniprot/A0A8C9MPK2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9135:LOC103822274 ^@ http://purl.uniprot.org/uniprot/A0A8C9N6W1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9135:BLCAP ^@ http://purl.uniprot.org/uniprot/A0A8C9NHQ1 ^@ Similarity ^@ Belongs to the BLCAP family. http://togogenome.org/gene/9135:RAG1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJX4 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RAG1 family.|||Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).|||Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.|||Homodimer.|||Nucleus|||The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp. http://togogenome.org/gene/9135:TMEM9 ^@ http://purl.uniprot.org/uniprot/A0A8C9MX78 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/9135:CNOT8 ^@ http://purl.uniprot.org/uniprot/A0A8C9NIP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/9135:SPIC ^@ http://purl.uniprot.org/uniprot/A0A8C9N975 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9135:TAF4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NP79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF4 family.|||Nucleus http://togogenome.org/gene/9135:MRPL53 ^@ http://purl.uniprot.org/uniprot/A0A8C9MG06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL53 family.|||Mitochondrion http://togogenome.org/gene/9135:MVB12B ^@ http://purl.uniprot.org/uniprot/A0A8C9NTX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MVB12 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9135:LOC103823463 ^@ http://purl.uniprot.org/uniprot/A0A8C9MNG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9135:CACNG2 ^@ http://purl.uniprot.org/uniprot/A0A8C9ML76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. http://togogenome.org/gene/9135:RNF152 ^@ http://purl.uniprot.org/uniprot/A0A8C9MG59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNF152 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9135:LOC103814121 ^@ http://purl.uniprot.org/uniprot/A0A8C9NP09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9135:LYZ ^@ http://purl.uniprot.org/uniprot/A0A8C9L3S3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 22 family.|||Secreted http://togogenome.org/gene/9135:LOC103826153 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/9135:TACR3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:LOC103825461 ^@ http://purl.uniprot.org/uniprot/A0A8C9UD57 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9135:LACC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NHT1 ^@ Similarity ^@ Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family. http://togogenome.org/gene/9135:PAPSS2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKT4 ^@ Similarity ^@ In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family. http://togogenome.org/gene/9135:FAM149B1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MMJ8|||http://purl.uniprot.org/uniprot/A0A8C9MMV1 ^@ Similarity ^@ Belongs to the FAM149 family. http://togogenome.org/gene/9135:P2RY2 ^@ http://purl.uniprot.org/uniprot/A0A8C9L279 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:CCNC ^@ http://purl.uniprot.org/uniprot/A0A8C9KVJ8 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9135:LOC103812493 ^@ http://purl.uniprot.org/uniprot/A0A8C9MEV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/9135:PLCB2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NBD0 ^@ Cofactor|||Function ^@ Binds 1 Ca(2+) ion per subunit.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/9135:PSMG1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N732 ^@ Similarity ^@ Belongs to the PSMG1 family. http://togogenome.org/gene/9135:ATP7B ^@ http://purl.uniprot.org/uniprot/A0A8C9NF85|||http://purl.uniprot.org/uniprot/A0A8C9NGQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9135:STAB2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N6D6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:PLA2G4F ^@ http://purl.uniprot.org/uniprot/A0A8C9KRE1 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9135:USP38 ^@ http://purl.uniprot.org/uniprot/A0A8C9NE16 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9135:CNN2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MU28 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/9135:PLA2R1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMA9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:STC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NW69 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9135:TSNAX ^@ http://purl.uniprot.org/uniprot/A0A8C9MJF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the translin family.|||Nucleus http://togogenome.org/gene/9135:LHPP ^@ http://purl.uniprot.org/uniprot/A0A8C9NJM2 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9135:CNOT10 ^@ http://purl.uniprot.org/uniprot/A0A8C9KRF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT10 family.|||Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:LOC103817382 ^@ http://purl.uniprot.org/uniprot/A0A8C9UER8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S33 family.|||Microsome membrane http://togogenome.org/gene/9135:AMFR ^@ http://purl.uniprot.org/uniprot/A0A8C9MP75 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:USP15 ^@ http://purl.uniprot.org/uniprot/A0A8C9L2N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:TRIAP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKY7 ^@ Similarity ^@ Belongs to the TRIAP1/MDM35 family. http://togogenome.org/gene/9135:CHFR ^@ http://purl.uniprot.org/uniprot/A0A8C9MNP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CHFR family.|||PML body http://togogenome.org/gene/9135:YIPF7 ^@ http://purl.uniprot.org/uniprot/A0A8C9UC25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/9135:FOXL2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NW66 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:THOC5 ^@ http://purl.uniprot.org/uniprot/A0A8C9KY41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC5 family.|||Nucleus http://togogenome.org/gene/9135:CPT1A ^@ http://purl.uniprot.org/uniprot/A0A8C9U6P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9135:AHSA2P ^@ http://purl.uniprot.org/uniprot/A0A8C9NGE4 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/9135:FUT9 ^@ http://purl.uniprot.org/uniprot/A0A8C9KTX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/9135:HARBI1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HARBI1 family.|||Cytoplasm|||Nucleus|||Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity. http://togogenome.org/gene/9135:PPIH ^@ http://purl.uniprot.org/uniprot/A0A8C9NNG4 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9135:ADAM12 ^@ http://purl.uniprot.org/uniprot/A0A8C9NG91 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:ATP5PD ^@ http://purl.uniprot.org/uniprot/A0A8C9L185 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase d subunit family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/9135:ACO2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MS70 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.|||Mitochondrion http://togogenome.org/gene/9135:VGLL4 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8W4 ^@ Function|||Similarity ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs. http://togogenome.org/gene/9135:PREPL ^@ http://purl.uniprot.org/uniprot/A0A8C9N8W0 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/9135:FUT11 ^@ http://purl.uniprot.org/uniprot/A0A8C9L588 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Probable fucosyltransferase. http://togogenome.org/gene/9135:GPD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N178 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/9135:TMA16 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8G1 ^@ Function|||Similarity|||Subunit ^@ Associates with pre-60S ribosomal particles.|||Belongs to the TMA16 family.|||Involved in the biogenesis of the 60S ribosomal subunit in the nucleus. http://togogenome.org/gene/9135:EBF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NIA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/9135:ETV6 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHK4|||http://purl.uniprot.org/uniprot/A0A8C9U2Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9135:CDR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAT1 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/9135:ELOA ^@ http://purl.uniprot.org/uniprot/A0A8C9MUB4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:CALHM5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NNT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9135:TCP11L1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MX82|||http://purl.uniprot.org/uniprot/A0A8C9MZJ8 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9135:KCNK1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Cell membrane|||Cytoplasmic vesicle|||Endosome|||Membrane|||Perikaryon|||Recycling endosome|||Synaptic cell membrane|||Vesicle|||dendrite http://togogenome.org/gene/9135:MAP2K1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N4X5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:FGG ^@ http://purl.uniprot.org/uniprot/A0A8C9NAY9 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/9135:LOC103820686 ^@ http://purl.uniprot.org/uniprot/A0A8C9UIE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:LOC103813954 ^@ http://purl.uniprot.org/uniprot/A0A8C9NTL3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:LOC103827112 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/9135:RPL14 ^@ http://purl.uniprot.org/uniprot/A0A8C9KS53 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/9135:LOC103826452 ^@ http://purl.uniprot.org/uniprot/A0A8C9UBJ6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9135:LOC103820491 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYN2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:LOC103820474 ^@ http://purl.uniprot.org/uniprot/A0A8C9MT90 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9135:SRPX ^@ http://purl.uniprot.org/uniprot/A0A8C9NA20|||http://purl.uniprot.org/uniprot/A0A8C9NE17 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:SLA ^@ http://purl.uniprot.org/uniprot/A0A8C9N1J2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9135:LDHB ^@ http://purl.uniprot.org/uniprot/A0A8C9N2W8 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9135:SEPTIN7 ^@ http://purl.uniprot.org/uniprot/A0A8C9UDE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cleavage furrow|||Midbody|||cilium axoneme|||kinetochore|||spindle http://togogenome.org/gene/9135:GPR146 ^@ http://purl.uniprot.org/uniprot/A0A8C9N523 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9135:UBE4B ^@ http://purl.uniprot.org/uniprot/A0A8C9NVV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm http://togogenome.org/gene/9135:GALNT11 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9135:GIMD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJS5 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9135:PRORP ^@ http://purl.uniprot.org/uniprot/A0A8C9N8Z7 ^@ Similarity ^@ Belongs to the PPR family. P subfamily. http://togogenome.org/gene/9135:LOC103815769 ^@ http://purl.uniprot.org/uniprot/A0A8C9NBH9 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/9135:CDR2L ^@ http://purl.uniprot.org/uniprot/A0A8C9MDW0 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/9135:ERGIC2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MPP8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/9135:AURKA ^@ http://purl.uniprot.org/uniprot/A0A8C9NKT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.|||centrosome http://togogenome.org/gene/9135:COPS5 ^@ http://purl.uniprot.org/uniprot/A0A8C9UG13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN5 subfamily.|||synaptic vesicle http://togogenome.org/gene/9135:SAP18 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQU8 ^@ Similarity ^@ Belongs to the SAP18 family. http://togogenome.org/gene/9135:DOCK5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NV72 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9135:TBXAS1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N726 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9135:PLAT ^@ http://purl.uniprot.org/uniprot/A0A8C9NV07 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9135:FAH ^@ http://purl.uniprot.org/uniprot/A0A8C9MRN2 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/9135:FUT8 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJ65 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 23 family.|||Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9135:LOC103812482 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/9135:ANXA6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NBG3|||http://purl.uniprot.org/uniprot/A0A8C9NDT5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.|||Melanosome http://togogenome.org/gene/9135:LOC103825220 ^@ http://purl.uniprot.org/uniprot/A0A8C9N0W3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9135:SEMA4G ^@ http://purl.uniprot.org/uniprot/A0A8C9UHX0 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:POMK ^@ http://purl.uniprot.org/uniprot/A0A8C9NHG3 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif. http://togogenome.org/gene/9135:ALKBH1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UCU0 ^@ Cofactor ^@ Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/9135:TMEM132A ^@ http://purl.uniprot.org/uniprot/A0A8C9N636 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM132 family.|||Membrane http://togogenome.org/gene/9135:USP48 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Nucleus http://togogenome.org/gene/9135:MDM1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM1 family.|||Nucleus|||centriole http://togogenome.org/gene/9135:TM9SF4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9135:CLCF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N297 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/9135:PCK1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UHN0 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. http://togogenome.org/gene/9135:ITGA6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPV3|||http://purl.uniprot.org/uniprot/A0A8C9NTJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9135:APOA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9U915 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9135:ATP6V1E1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRT9 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/9135:CDH19 ^@ http://purl.uniprot.org/uniprot/A0A8C9MX36 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/9135:LDB1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NVS2 ^@ Similarity ^@ Belongs to the LDB family. http://togogenome.org/gene/9135:SH3YL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9ND74 ^@ Similarity ^@ Belongs to the SH3YL1 family. http://togogenome.org/gene/9135:LOC103819184 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFY7 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9135:PCNX4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MQE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/9135:GMPR ^@ http://purl.uniprot.org/uniprot/A0A8C9KQK4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer. http://togogenome.org/gene/9135:LOC103814919 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGT8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:CAPN10 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJA9 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9135:CLK4 ^@ http://purl.uniprot.org/uniprot/A0A8C9UE71 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:EPHX1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S33 family.|||Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9135:ID2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDW4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:CES2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAN4|||http://purl.uniprot.org/uniprot/A0A8C9NEE1 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/9135:LOC103813961 ^@ http://purl.uniprot.org/uniprot/A0A8C9NXX4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9135:C11H16orf87 ^@ http://purl.uniprot.org/uniprot/A0A8C9U7L8 ^@ Similarity ^@ Belongs to the UPF0547 family. http://togogenome.org/gene/9135:MCMBP ^@ http://purl.uniprot.org/uniprot/A0A8C9NJ43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCMBP family.|||Nucleus http://togogenome.org/gene/9135:FLI1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NYA0|||http://purl.uniprot.org/uniprot/A0A8C9UIF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9135:SHOX ^@ http://purl.uniprot.org/uniprot/A0A8C9NUX8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:SEC61A2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N6Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:P2RY8 ^@ http://purl.uniprot.org/uniprot/A0A8C9NVJ1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:LOC103822899 ^@ http://purl.uniprot.org/uniprot/A0A8C9U399 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9135:P2RY4 ^@ http://purl.uniprot.org/uniprot/A0A8C9L1R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:WT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Cytoplasm|||Nucleus speckle http://togogenome.org/gene/9135:SLC1A3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MXZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9135:MOCOS ^@ http://purl.uniprot.org/uniprot/A0A8C9U984 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.|||Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. http://togogenome.org/gene/9135:FGF12 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQN6 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9135:MRPS18C ^@ http://purl.uniprot.org/uniprot/A0A8C9NPL2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS18 family. http://togogenome.org/gene/9135:YEATS4 ^@ http://purl.uniprot.org/uniprot/A0A8C9N546 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:FAM135A ^@ http://purl.uniprot.org/uniprot/A0A8C9N0V7 ^@ Similarity ^@ Belongs to the FAM135 family. http://togogenome.org/gene/9135:SLC37A2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRG5|||http://purl.uniprot.org/uniprot/A0A8C9UIY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/9135:LOC103823829 ^@ http://purl.uniprot.org/uniprot/A0A8C9KUX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9135:CPNE8 ^@ http://purl.uniprot.org/uniprot/A0A8C9MPA4 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9135:BOLA3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MM57 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/9135:RPL34 ^@ http://purl.uniprot.org/uniprot/A0A8C9NH26 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/9135:XPNPEP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UI12 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/9135:MYO19 ^@ http://purl.uniprot.org/uniprot/A0A8C9N9E8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9135:MRPL43 ^@ http://purl.uniprot.org/uniprot/A0A8C9UIF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL43 family.|||Mitochondrion http://togogenome.org/gene/9135:MRPS5 ^@ http://purl.uniprot.org/uniprot/A0A8C9L2S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS5 family.|||Nucleus http://togogenome.org/gene/9135:FHL5 ^@ http://purl.uniprot.org/uniprot/A0A8C9L629 ^@ Function|||Subcellular Location Annotation ^@ May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.|||Nucleus http://togogenome.org/gene/9135:ARSI ^@ http://purl.uniprot.org/uniprot/A0A8C9NCA0 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9135:GART ^@ http://purl.uniprot.org/uniprot/A0A8C9U754 ^@ Similarity ^@ In the C-terminal section; belongs to the GART family.|||In the N-terminal section; belongs to the GARS family.|||In the central section; belongs to the AIR synthase family. http://togogenome.org/gene/9135:NPBWR2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UH32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:TMEM150C ^@ http://purl.uniprot.org/uniprot/A0A8C9NPW1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:CENPJ ^@ http://purl.uniprot.org/uniprot/A0A8C9U9D8 ^@ Similarity ^@ Belongs to the TCP10 family. http://togogenome.org/gene/9135:B4GALT4 ^@ http://purl.uniprot.org/uniprot/A0A8C9N6P8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9135:SPCS1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KU24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:TPMT ^@ http://purl.uniprot.org/uniprot/A0A8C9L5L6|||http://purl.uniprot.org/uniprot/A0A8C9MEZ5 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. http://togogenome.org/gene/9135:ODF2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MU68|||http://purl.uniprot.org/uniprot/A0A8C9MU79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ODF2 family.|||centrosome http://togogenome.org/gene/9135:PTGES ^@ http://purl.uniprot.org/uniprot/A0A8C9MPX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/9135:SLC5A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MK31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/9135:ZDHHC14 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKS7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9135:MYOZ1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MFA4 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9135:GAL3ST1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KWI1 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/9135:ACSL5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NTJ0 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. http://togogenome.org/gene/9135:LOC103812328 ^@ http://purl.uniprot.org/uniprot/A0A8C9NVF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm http://togogenome.org/gene/9135:CMKLR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MY01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:CLDN14 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8R3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9135:RRM2B ^@ http://purl.uniprot.org/uniprot/A0A8C9MME8 ^@ Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family. http://togogenome.org/gene/9135:UBA5 ^@ http://purl.uniprot.org/uniprot/A0A8C9L4Z4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.|||Golgi apparatus http://togogenome.org/gene/9135:VAMP3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MH00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9135:HMBS ^@ http://purl.uniprot.org/uniprot/A0A8C9NVC5 ^@ Similarity ^@ Belongs to the HMBS family. http://togogenome.org/gene/9135:SLC46A3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTI9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:ODR4 ^@ http://purl.uniprot.org/uniprot/A0A8C9N529 ^@ Function|||Similarity ^@ Belongs to the ODR-4 family.|||May play a role in the trafficking of a subset of G-protein coupled receptors. http://togogenome.org/gene/9135:USP49 ^@ http://purl.uniprot.org/uniprot/A0A8C9L1F6 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9135:CNOT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT1 family.|||Nucleus http://togogenome.org/gene/9135:RBPJ ^@ http://purl.uniprot.org/uniprot/A0A8C9MN25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Su(H) family.|||Nucleus http://togogenome.org/gene/9135:ORC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MS12 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CDC6/cdc18 family.|||Belongs to the ORC1 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Nucleus|||ORC is composed of six subunits. http://togogenome.org/gene/9135:CALHM1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NVK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9135:NRGN ^@ http://purl.uniprot.org/uniprot/P54866 ^@ Function|||Similarity ^@ Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).|||Belongs to the neurogranin family. http://togogenome.org/gene/9135:MMP11 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJA0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9135:DOK5 ^@ http://purl.uniprot.org/uniprot/A0A8C9NND0 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/9135:GPR183 ^@ http://purl.uniprot.org/uniprot/A0A8C9UHI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:PRDM10 ^@ http://purl.uniprot.org/uniprot/A0A8C9NWY3 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9135:ZFPM2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTW3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:EIF3D ^@ http://purl.uniprot.org/uniprot/A0A8C9MKS1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit D family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Cytoplasm|||The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.|||mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. http://togogenome.org/gene/9135:MED30 ^@ http://purl.uniprot.org/uniprot/A0A8C9MWI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 30 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9135:ABCC10 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDR2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:CEBPG ^@ http://purl.uniprot.org/uniprot/A0A8C9NDY2 ^@ Similarity ^@ Belongs to the bZIP family. C/EBP subfamily. http://togogenome.org/gene/9135:LOC103813624 ^@ http://purl.uniprot.org/uniprot/A0A8C9MSW7 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9135:SMC6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NE45 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/9135:TADA3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MR57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGG1 family.|||Nucleus http://togogenome.org/gene/9135:COPB2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UIM0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat COPB2 family.|||COPI-coated vesicle membrane|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.|||This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner. http://togogenome.org/gene/9135:AASDHPPT ^@ http://purl.uniprot.org/uniprot/A0A8C9MLS1 ^@ Similarity ^@ Belongs to the P-Pant transferase superfamily. AcpS family. http://togogenome.org/gene/9135:KAT6A ^@ http://purl.uniprot.org/uniprot/A0A8C9NVB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9135:LOC103816733 ^@ http://purl.uniprot.org/uniprot/A0A8C9MW00 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/9135:MAFK ^@ http://purl.uniprot.org/uniprot/A0A8C9N5A8 ^@ Similarity ^@ Belongs to the bZIP family. Maf subfamily. http://togogenome.org/gene/9135:POPDC3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MEZ8 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9135:LAMP3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NE33 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9135:JPT2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGW3|||http://purl.uniprot.org/uniprot/A0A8C9MGZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:CDC25A ^@ http://purl.uniprot.org/uniprot/A0A8C9MQP1 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/9135:EXOC3L4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUQ8|||http://purl.uniprot.org/uniprot/A0A8C9MV70 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/9135:SPSB1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NW90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Cytoplasm http://togogenome.org/gene/9135:DHX30 ^@ http://purl.uniprot.org/uniprot/A0A8C9MR78 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. http://togogenome.org/gene/9135:CDK14 ^@ http://purl.uniprot.org/uniprot/A0A8C9NBZ0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9135:LOC103826888 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYA9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9135:TMEM45B ^@ http://purl.uniprot.org/uniprot/A0A8C9NU52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9135:CRYBG1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KU75 ^@ Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. http://togogenome.org/gene/9135:GHRHR ^@ http://purl.uniprot.org/uniprot/A0A8C9UBA6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:TAGLN3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQJ4 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/9135:PHYKPL ^@ http://purl.uniprot.org/uniprot/A0A8C9N8G9 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9135:ARL6 ^@ http://purl.uniprot.org/uniprot/A0A8C9NEV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||cilium membrane http://togogenome.org/gene/9135:LOC103822691 ^@ http://purl.uniprot.org/uniprot/A0A8C9NUR4 ^@ Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family. http://togogenome.org/gene/9135:FAM174C ^@ http://purl.uniprot.org/uniprot/A0A8C9MUM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/9135:ELF3 ^@ http://purl.uniprot.org/uniprot/A0A8C9UB60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9135:SKA3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MRE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SKA3 family.|||kinetochore|||spindle http://togogenome.org/gene/9135:LOC103813347 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUQ2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9135:LOC103817985 ^@ http://purl.uniprot.org/uniprot/A0A8C9KYH0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCR10/QCR9 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9135:OTOP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9L2X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:TMPRSS13 ^@ http://purl.uniprot.org/uniprot/A0A8C9UA71 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:RAB4A ^@ http://purl.uniprot.org/uniprot/A0A8C9MJM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. http://togogenome.org/gene/9135:NFRKB ^@ http://purl.uniprot.org/uniprot/A0A8C9NU42 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:TAF1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF1 family.|||Nucleus http://togogenome.org/gene/9135:RCAN1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N7J0|||http://purl.uniprot.org/uniprot/A0A8C9N9N3 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/9135:TCP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NBL7 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/9135:CRYBA2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJ46 ^@ Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. http://togogenome.org/gene/9135:INPP5B ^@ http://purl.uniprot.org/uniprot/A0A8C9NRK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.|||Early endosome membrane|||Endosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/9135:GPSM1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MGE2|||http://purl.uniprot.org/uniprot/A0A8C9U3M7 ^@ Similarity ^@ Belongs to the GPSM family. http://togogenome.org/gene/9135:PRPF19 ^@ http://purl.uniprot.org/uniprot/A0A8C9N4Y8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat PRP19 family.|||Homotetramer.|||Lipid droplet|||Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.|||nucleoplasm http://togogenome.org/gene/9135:NDUFA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NX41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA1 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9135:NTF3 ^@ http://purl.uniprot.org/uniprot/A0A8C9UC43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Secreted|||Seems to promote the survival of visceral and proprioceptive sensory neurons. http://togogenome.org/gene/9135:LOC103824340 ^@ http://purl.uniprot.org/uniprot/A0A8C9L3H9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9135:CYP2J19 ^@ http://purl.uniprot.org/uniprot/A0A8C9MW13 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9135:PRKAB2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NPU0 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/9135:NUDT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N3E9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family.|||Monomer.|||Nucleus http://togogenome.org/gene/9135:EEF2K ^@ http://purl.uniprot.org/uniprot/A0A8C9N857|||http://purl.uniprot.org/uniprot/A0A8C9N9H9 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. Alpha-type protein kinase family.|||Monomer or homodimer.|||Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent. http://togogenome.org/gene/9135:FOXB1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UHV2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:PTGFR ^@ http://purl.uniprot.org/uniprot/A0A8C9NM16 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9135:HYAL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KXR4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9135:GJC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1T5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Gamma-type subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9135:RPLP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N409 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/9135:EIF3E ^@ http://purl.uniprot.org/uniprot/A0A8C9MUL0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit E family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9135:RRH ^@ http://purl.uniprot.org/uniprot/A0A8C9NHP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9135:NMBR ^@ http://purl.uniprot.org/uniprot/A0A8C9UGG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:IL2RB ^@ http://purl.uniprot.org/uniprot/A0A8C9MLD5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Cell membrane|||Membrane|||Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. http://togogenome.org/gene/9135:LOC103820700 ^@ http://purl.uniprot.org/uniprot/A0A8C9NTN9 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/9135:GJA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGE3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9135:UGP2 ^@ http://purl.uniprot.org/uniprot/A0A8C9KUI4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Homooctamer.|||UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. http://togogenome.org/gene/9135:EIF1B ^@ http://purl.uniprot.org/uniprot/A0A8C9KTZ8 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/9135:UROC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MPZ3 ^@ Similarity ^@ Belongs to the urocanase family. http://togogenome.org/gene/9135:ACTA2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NY38 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9135:TMCO1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MER7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMCO1 family.|||Calcium-selective channel required to prevent calcium stores from overfilling.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:KDM1B ^@ http://purl.uniprot.org/uniprot/A0A8C9L2J8 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/9135:CLDN11 ^@ http://purl.uniprot.org/uniprot/A0A8C9N859 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9135:XPR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9L2V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SYG1 (TC 2.A.94) family.|||Membrane http://togogenome.org/gene/9135:LOC103826028 ^@ http://purl.uniprot.org/uniprot/A0A8C9NJY7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9135:ACTA1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJH4 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9135:HOXA11 ^@ http://purl.uniprot.org/uniprot/A0A8C9NRA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9135:OXCT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2M3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 3-oxoacid CoA-transferase family.|||Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.|||Mitochondrion http://togogenome.org/gene/9135:MMP23B ^@ http://purl.uniprot.org/uniprot/A0A8C9NYB8 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:HDC ^@ http://purl.uniprot.org/uniprot/A0A8C9MQR1 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9135:GALR3 ^@ http://purl.uniprot.org/uniprot/A0A8C9U6A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9135:VEGFD ^@ http://purl.uniprot.org/uniprot/A0A8C9NK74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Secreted http://togogenome.org/gene/9135:HEATR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MM08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HEATR1/UTP10 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/9135:CX3CR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KZV4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9135:C8B ^@ http://purl.uniprot.org/uniprot/A0A8C9UA79 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9135:OTULINL ^@ http://purl.uniprot.org/uniprot/A0A8C9MLB4|||http://purl.uniprot.org/uniprot/A0A8C9MM20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C65 family. Otulin subfamily.|||Cytoplasm http://togogenome.org/gene/9135:FAM83C ^@ http://purl.uniprot.org/uniprot/A0A8C9N7K1 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9135:NT5C2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NSQ8 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/9135:PDE7B ^@ http://purl.uniprot.org/uniprot/A0A8C9MH57 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9135:MAN1C1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MWF1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9135:NDRG3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAD3|||http://purl.uniprot.org/uniprot/A0A8C9NDK5 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/9135:LOC103825943 ^@ http://purl.uniprot.org/uniprot/A0A8C9MSM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9135:MYH9 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLK7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9135:ALX4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJ39 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:VTI1B ^@ http://purl.uniprot.org/uniprot/A0A8C9UG22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/9135:COPG1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MNH3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9135:POSTN ^@ http://purl.uniprot.org/uniprot/A0A8C9NC68|||http://purl.uniprot.org/uniprot/A0A8C9NDX9|||http://purl.uniprot.org/uniprot/A0A8C9NFH9|||http://purl.uniprot.org/uniprot/A0A8C9NHX9 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9135:GRHL3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVS5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:TADA2B ^@ http://purl.uniprot.org/uniprot/A0A8C9UI30 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:NXPH1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NGH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/9135:LOC103820036 ^@ http://purl.uniprot.org/uniprot/A0A8C9MKP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9135:RRAGD ^@ http://purl.uniprot.org/uniprot/A0A8C9U2S2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9135:ADCK1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N380 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family.|||Secreted http://togogenome.org/gene/9135:SOSTDC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NK67 ^@ Caution|||Similarity ^@ Belongs to the sclerostin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:ST6GALNAC2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MIB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9135:LOC103812565 ^@ http://purl.uniprot.org/uniprot/A0A8C9NEX9 ^@ Similarity ^@ Belongs to the PTEN phosphatase protein family. http://togogenome.org/gene/9135:NDUFB5 ^@ http://purl.uniprot.org/uniprot/A0A8C9UF13 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB5 subunit family.|||Complex I is composed of 45 different subunits. http://togogenome.org/gene/9135:MDM4 ^@ http://purl.uniprot.org/uniprot/A0A8C9MWQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.|||Nucleus http://togogenome.org/gene/9135:VEGFC ^@ http://purl.uniprot.org/uniprot/A0A8C9UDH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Secreted http://togogenome.org/gene/9135:AP3M2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NV98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus http://togogenome.org/gene/9135:LRRC8B ^@ http://purl.uniprot.org/uniprot/A0A8C9NK44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:EIF2B1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N2Y5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2B alpha/beta/delta subunits family.|||Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.|||Complex of five different subunits; alpha, beta, gamma, delta and epsilon. http://togogenome.org/gene/9135:SLC25A19 ^@ http://purl.uniprot.org/uniprot/A0A8C9KR30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9135:SLC37A4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NTN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/9135:MTX2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NU40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9135:CBR1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NAF2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9135:CLCC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NB16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel MCLC family.|||Membrane http://togogenome.org/gene/9135:INO80D ^@ http://purl.uniprot.org/uniprot/A0A8C9MFH8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9135:SLC46A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVE9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:ACTC1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NDN5 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9135:LOC103816736 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUU9 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/9135:TEX10 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVC2 ^@ Similarity ^@ Belongs to the IPI1/TEX10 family. http://togogenome.org/gene/9135:MBOAT1 ^@ http://purl.uniprot.org/uniprot/A0A8C9KVD0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:SNW1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N1D4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNW family.|||Identified in the spliceosome C complex.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/9135:SLC18A2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NK72 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:IL17REL ^@ http://purl.uniprot.org/uniprot/A0A8C9MKP2 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9135:CRAT ^@ http://purl.uniprot.org/uniprot/A0A8C9MPW2 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9135:KCNQ5 ^@ http://purl.uniprot.org/uniprot/A0A8C9MYN7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9135:ELK3 ^@ http://purl.uniprot.org/uniprot/A0A8C9MVH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9135:LOC103817657 ^@ http://purl.uniprot.org/uniprot/A0A8C9N4E1 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/9135:UNC5A ^@ http://purl.uniprot.org/uniprot/A0A8C9NI85 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/9135:NECAP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQG1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9135:STARD8 ^@ http://purl.uniprot.org/uniprot/A0A8C9KQI0|||http://purl.uniprot.org/uniprot/A0A8C9KWN6|||http://purl.uniprot.org/uniprot/A0A8C9MEX9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9135:DPYS ^@ http://purl.uniprot.org/uniprot/A0A8C9MTA7 ^@ PTM|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Carbamylation allows a single lysine to coordinate two divalent metal cations. http://togogenome.org/gene/9135:PRKCI ^@ http://purl.uniprot.org/uniprot/A0A8C9N4A2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. http://togogenome.org/gene/9135:LOC103817463 ^@ http://purl.uniprot.org/uniprot/A0A8C9N7M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shroom family.|||cytoskeleton http://togogenome.org/gene/9135:GTF2E1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N605 ^@ Function|||Similarity ^@ Belongs to the TFIIE alpha subunit family.|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. http://togogenome.org/gene/9135:EIF4A3 ^@ http://purl.uniprot.org/uniprot/A0A8C9KTD9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9135:LOC103819810 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKK8 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9135:MFN2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MHQ0 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9135:TMEM53 ^@ http://purl.uniprot.org/uniprot/A0A8C9L1U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM53 family.|||Membrane|||Nucleus outer membrane http://togogenome.org/gene/9135:UROS ^@ http://purl.uniprot.org/uniprot/A0A8C9NJG7 ^@ Similarity ^@ Belongs to the uroporphyrinogen-III synthase family. http://togogenome.org/gene/9135:TFB1M ^@ http://purl.uniprot.org/uniprot/A0A8C9NJG9 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/9135:RABGGTB ^@ http://purl.uniprot.org/uniprot/A0A8C9N1T8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX. http://togogenome.org/gene/9135:DOLK ^@ http://purl.uniprot.org/uniprot/A0A8C9U7V4 ^@ Similarity ^@ Belongs to the polyprenol kinase family. http://togogenome.org/gene/9135:LUC7L3 ^@ http://purl.uniprot.org/uniprot/A0A8C9NNK0 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9135:TPM4 ^@ http://purl.uniprot.org/uniprot/A0A8C9NM87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9135:AIG1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NN93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane http://togogenome.org/gene/9135:TEF ^@ http://purl.uniprot.org/uniprot/A0A8C9MR01|||http://purl.uniprot.org/uniprot/A0A8C9MRK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/9135:SFRP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NT33 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9135:DDX3X ^@ http://purl.uniprot.org/uniprot/A0A8C9NDR5 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9135:TM4SF18 ^@ http://purl.uniprot.org/uniprot/A0A8C9N243 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9135:CRYL1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MPD6 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/9135:ATP5F1C ^@ http://purl.uniprot.org/uniprot/A0A8C9N7A5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/9135:MRPS25 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS25 family.|||Mitochondrion http://togogenome.org/gene/9135:MRPL32 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQ76 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/9135:AP2A2 ^@ http://purl.uniprot.org/uniprot/A0A8C9U672 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).|||Belongs to the adaptor complexes large subunit family.|||Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.|||coated pit http://togogenome.org/gene/9135:HOXD10 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9135:UBP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NLD7|||http://purl.uniprot.org/uniprot/A0A8C9NR22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/9135:APOH ^@ http://purl.uniprot.org/uniprot/A0A8C9NHM9 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9135:NOX1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJD1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9135:ACYP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N329 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/9135:YTHDF3 ^@ http://purl.uniprot.org/uniprot/A0A8C9UGN4 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/9135:LOC103818022 ^@ http://purl.uniprot.org/uniprot/A0A8C9MJU2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transferrin family.|||Monomer.|||Secreted http://togogenome.org/gene/9135:ANAPC10 ^@ http://purl.uniprot.org/uniprot/A0A8C9UHC9 ^@ Function|||Similarity ^@ Belongs to the APC10 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/9135:NDUFA2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UDE5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9135:CDC42EP3 ^@ http://purl.uniprot.org/uniprot/A0A8C9UF46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9135:OXTR ^@ http://purl.uniprot.org/uniprot/A0A8C9NR82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:UNC93A ^@ http://purl.uniprot.org/uniprot/A0A8C9U3T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/9135:LOC103823243 ^@ http://purl.uniprot.org/uniprot/A0A8C9NMP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9135:NOL10 ^@ http://purl.uniprot.org/uniprot/A0A8C9NET4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat NOL10/ENP2 family.|||nucleolus http://togogenome.org/gene/9135:LOC103826450 ^@ http://purl.uniprot.org/uniprot/A0A8C9MXN2 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9135:APTX ^@ http://purl.uniprot.org/uniprot/A0A8C9NA18 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9135:CAB39L ^@ http://purl.uniprot.org/uniprot/A0A8C9NJQ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/9135:RIC8A ^@ http://purl.uniprot.org/uniprot/A0A8C9N1K2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. http://togogenome.org/gene/9135:SEC61A1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MNS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9135:SDAD1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MLV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDA1 family.|||Required for 60S pre-ribosomal subunits export to the cytoplasm.|||nucleolus http://togogenome.org/gene/9135:FGA ^@ http://purl.uniprot.org/uniprot/A0A8C9NDK4 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/9135:CTNS ^@ http://purl.uniprot.org/uniprot/A0A8C9UDM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cystinosin family.|||Membrane http://togogenome.org/gene/9135:DYNLRB1 ^@ http://purl.uniprot.org/uniprot/A0A8C9N0P9 ^@ Similarity ^@ Belongs to the GAMAD family. http://togogenome.org/gene/9135:ENTPD2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NCL3 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9135:ITGB3 ^@ http://purl.uniprot.org/uniprot/A0A8C9N8P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:RPS6KA5 ^@ http://purl.uniprot.org/uniprot/A0A8C9N0U8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9135:EPYC ^@ http://purl.uniprot.org/uniprot/A0A8C9UC65 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/9135:ATP5F1A ^@ http://purl.uniprot.org/uniprot/A0A8C9NV97 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/9135:HMGCL ^@ http://purl.uniprot.org/uniprot/A0A8C9MW72 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HMG-CoA lyase family.|||Homodimer; disulfide-linked. Can also form homotetramers.|||Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. http://togogenome.org/gene/9135:TIMM21 ^@ http://purl.uniprot.org/uniprot/A0A8C9MXW1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM21 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/9135:PUS7L ^@ http://purl.uniprot.org/uniprot/A0A8C9NIF0 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/9135:TRPM2 ^@ http://purl.uniprot.org/uniprot/A0A8C9N0G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9135:HYOU1 ^@ http://purl.uniprot.org/uniprot/A0A8C9NYE7 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9135:LOC103817855 ^@ http://purl.uniprot.org/uniprot/A0A8C9N4B1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9135:FUT7 ^@ http://purl.uniprot.org/uniprot/A0A8C9N7K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/9135:ATP2C2 ^@ http://purl.uniprot.org/uniprot/A0A8C9MTX9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9135:PSMD2 ^@ http://purl.uniprot.org/uniprot/A0A8C9NKE3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S2 family.|||Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/9135:FECH ^@ http://purl.uniprot.org/uniprot/A0A8C9MJT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferrochelatase family.|||Catalyzes the ferrous insertion into protoporphyrin IX.|||Mitochondrion inner membrane http://togogenome.org/gene/9135:EMP1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MUZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/9135:LOC103823672 ^@ http://purl.uniprot.org/uniprot/A0A8C9NQ21 ^@ Similarity ^@ Belongs to the SLBP family. http://togogenome.org/gene/9135:BDKRB1 ^@ http://purl.uniprot.org/uniprot/A0A8C9MXD0 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. http://togogenome.org/gene/9135:GNL2 ^@ http://purl.uniprot.org/uniprot/A0A8C9UHI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.|||GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.|||nucleolus