http://togogenome.org/gene/9258:SCOC ^@ http://purl.uniprot.org/uniprot/A0A6I8NH21 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SCOC family.|||Positive regulator of amino acid starvation-induced autophagy.|||trans-Golgi network http://togogenome.org/gene/9258:BOK ^@ http://purl.uniprot.org/uniprot/F7AGS1 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9258:VPS53 ^@ http://purl.uniprot.org/uniprot/F7FTE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS53 family.|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9258:ALDH8A1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NVL9 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9258:CCDC25 ^@ http://purl.uniprot.org/uniprot/A0A6I8MY06|||http://purl.uniprot.org/uniprot/F6RD85 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC25 family.|||Cell membrane|||Endomembrane system|||Interacts (via cytoplasmic region) with ILK. http://togogenome.org/gene/9258:CYP1D1 ^@ http://purl.uniprot.org/uniprot/F6T232 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9258:GPD2 ^@ http://purl.uniprot.org/uniprot/F6WTM1 ^@ Function|||Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.|||Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device. http://togogenome.org/gene/9258:GDPD1 ^@ http://purl.uniprot.org/uniprot/F6WP77 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9258:TM4SF1 ^@ http://purl.uniprot.org/uniprot/F7EWP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9258:PFN3 ^@ http://purl.uniprot.org/uniprot/A0A6I8NLV1 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/9258:VCAM1 ^@ http://purl.uniprot.org/uniprot/A0A6I8N8A0 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9258:NT5C3A ^@ http://purl.uniprot.org/uniprot/F6Z8C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/9258:YBEY ^@ http://purl.uniprot.org/uniprot/A0A6I8P2L3 ^@ Similarity ^@ Belongs to the endoribonuclease YbeY family. http://togogenome.org/gene/9258:PIR ^@ http://purl.uniprot.org/uniprot/F7E913 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/9258:LZTFL1 ^@ http://purl.uniprot.org/uniprot/F6WD17 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LZTFL1 family.|||Cytoplasm|||Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.|||Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking. http://togogenome.org/gene/9258:NPVF ^@ http://purl.uniprot.org/uniprot/K7E9N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FARP (FMRFamide related peptide) family.|||Secreted http://togogenome.org/gene/9258:TSPAN14 ^@ http://purl.uniprot.org/uniprot/F7AFP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9258:MON1A ^@ http://purl.uniprot.org/uniprot/F7DQX4 ^@ Function|||Similarity ^@ Belongs to the MON1/SAND family.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/9258:LOC100093154 ^@ http://purl.uniprot.org/uniprot/F6PX78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:SGK1 ^@ http://purl.uniprot.org/uniprot/F6YI88|||http://purl.uniprot.org/uniprot/K7ED10 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9258:UCN3 ^@ http://purl.uniprot.org/uniprot/A0A6I8N5B4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Binds with high affinity to CRF receptors 2-alpha and 2-beta.|||Secreted|||Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. http://togogenome.org/gene/9258:LOC100680802 ^@ http://purl.uniprot.org/uniprot/A0A6I8PDH9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:ACTA2 ^@ http://purl.uniprot.org/uniprot/F7F4W9 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9258:LOC103165089 ^@ http://purl.uniprot.org/uniprot/F6UME2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LEG1 family.|||Secreted http://togogenome.org/gene/9258:RACK1 ^@ http://purl.uniprot.org/uniprot/F7E8M7 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. http://togogenome.org/gene/9258:CLRN2 ^@ http://purl.uniprot.org/uniprot/A0A6I8NST2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9258:ORNANAV1R3259 ^@ http://purl.uniprot.org/uniprot/A0A6I8MXZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:XKRX ^@ http://purl.uniprot.org/uniprot/A0A6I8P1W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9258:HOXA5 ^@ http://purl.uniprot.org/uniprot/F7EJA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9258:LOC103168722 ^@ http://purl.uniprot.org/uniprot/P0C8A3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the alpha-defensin family.|||Has antimicrobial activity.|||Highly expressed in spleen, and expressed at lower levels in intestin and lung.|||Secreted http://togogenome.org/gene/9258:HOXB4 ^@ http://purl.uniprot.org/uniprot/A0A6I8P2V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9258:C7H6orf89 ^@ http://purl.uniprot.org/uniprot/F6W2J5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9258:LOC100090615 ^@ http://purl.uniprot.org/uniprot/F7GCV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9258:PPDPFL ^@ http://purl.uniprot.org/uniprot/F7CKK5 ^@ Similarity ^@ Belongs to the PPDPF family. http://togogenome.org/gene/9258:DUSP26 ^@ http://purl.uniprot.org/uniprot/F6RVX7 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9258:CD40LG ^@ http://purl.uniprot.org/uniprot/A0A6I8NI35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.|||Belongs to the tumor necrosis factor family.|||Cell surface|||Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.|||Homotrimer. http://togogenome.org/gene/9258:JAKMIP2 ^@ http://purl.uniprot.org/uniprot/F7DIJ8 ^@ Similarity ^@ Belongs to the JAKMIP family. http://togogenome.org/gene/9258:IDO2 ^@ http://purl.uniprot.org/uniprot/B3Y9H7 ^@ Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family. http://togogenome.org/gene/9258:TRAPPC2 ^@ http://purl.uniprot.org/uniprot/F7CLV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/9258:CDK2AP1 ^@ http://purl.uniprot.org/uniprot/A0A6I8P6B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDK2AP family.|||Nucleus http://togogenome.org/gene/9258:LOC100081772 ^@ http://purl.uniprot.org/uniprot/F6QF42 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).|||Nucleus http://togogenome.org/gene/9258:ORAI3 ^@ http://purl.uniprot.org/uniprot/A0A6I8NMG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Orai family.|||Membrane http://togogenome.org/gene/9258:MDH1 ^@ http://purl.uniprot.org/uniprot/F7DK14 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family.|||Homodimer. http://togogenome.org/gene/9258:GPR68 ^@ http://purl.uniprot.org/uniprot/F6U2E0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9258:AHCYL2 ^@ http://purl.uniprot.org/uniprot/A0A6I8P214|||http://purl.uniprot.org/uniprot/F7A3U6 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/9258:SLCO4A1 ^@ http://purl.uniprot.org/uniprot/F7DID9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:ZWILCH ^@ http://purl.uniprot.org/uniprot/F7FDV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZWILCH family.|||Component of the RZZ complex.|||Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.|||kinetochore http://togogenome.org/gene/9258:ADIPOR1 ^@ http://purl.uniprot.org/uniprot/F6YTG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9258:PTPA ^@ http://purl.uniprot.org/uniprot/F7BSD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTPA-type PPIase family.|||Cytoplasm|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9258:LOC100077967 ^@ http://purl.uniprot.org/uniprot/A0A6I8NJR4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9258:TOR3A ^@ http://purl.uniprot.org/uniprot/F7AGI3 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. Torsin subfamily. http://togogenome.org/gene/9258:SNRPA1 ^@ http://purl.uniprot.org/uniprot/F6T1N4 ^@ Similarity ^@ Belongs to the U2 small nuclear ribonucleoprotein A family. http://togogenome.org/gene/9258:YAE1 ^@ http://purl.uniprot.org/uniprot/F6ZY55 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9258:LOC100093145 ^@ http://purl.uniprot.org/uniprot/F7A6K4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:ORNANAV1R3129 ^@ http://purl.uniprot.org/uniprot/F6XAY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:QRSL1 ^@ http://purl.uniprot.org/uniprot/F7A3P2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/9258:LOC100076077 ^@ http://purl.uniprot.org/uniprot/F7F1V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9258:TWF1 ^@ http://purl.uniprot.org/uniprot/F7EGY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.|||cytoskeleton http://togogenome.org/gene/9258:FAM216B ^@ http://purl.uniprot.org/uniprot/K7ECY3 ^@ Similarity ^@ Belongs to the FAM216 family. http://togogenome.org/gene/9258:ITM2B ^@ http://purl.uniprot.org/uniprot/F7E819 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/9258:GCNT1 ^@ http://purl.uniprot.org/uniprot/F6R1I2 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9258:APEX1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NWR6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/9258:IGF2 ^@ http://purl.uniprot.org/uniprot/Q673F3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.|||Secreted http://togogenome.org/gene/9258:SNTG2 ^@ http://purl.uniprot.org/uniprot/F6ZT92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||cytoskeleton http://togogenome.org/gene/9258:KEF28_p06 ^@ http://purl.uniprot.org/uniprot/Q36456 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 3 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM186. Interacts with TMEM242 (By similarity).|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.|||Mitochondrion inner membrane http://togogenome.org/gene/9258:FBLN5 ^@ http://purl.uniprot.org/uniprot/F6T7F1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9258:PATZ1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NET0|||http://purl.uniprot.org/uniprot/F7DSP0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:EIF5A2 ^@ http://purl.uniprot.org/uniprot/A0A6I8MXU1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group. http://togogenome.org/gene/9258:KIF3C ^@ http://purl.uniprot.org/uniprot/F7EES4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9258:ORNANAV1R3150 ^@ http://purl.uniprot.org/uniprot/A0A6I8NEK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:SLA ^@ http://purl.uniprot.org/uniprot/F6UH22 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9258:MPP1 ^@ http://purl.uniprot.org/uniprot/F7CAB5 ^@ Function|||Subcellular Location Annotation ^@ Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.|||stereocilium http://togogenome.org/gene/9258:SUCLA2 ^@ http://purl.uniprot.org/uniprot/A0A6I8N9T9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.|||Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.|||Mitochondrion http://togogenome.org/gene/9258:LOC100083475 ^@ http://purl.uniprot.org/uniprot/F7A481 ^@ Similarity ^@ Belongs to the intercrine gamma family. http://togogenome.org/gene/9258:RAB27B ^@ http://purl.uniprot.org/uniprot/A0A6I8P1C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/9258:ORNANAV1R3012 ^@ http://purl.uniprot.org/uniprot/A0A6I8N3D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:PRND ^@ http://purl.uniprot.org/uniprot/A0A6I8N183 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prion family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:ORNANAV1R3114 ^@ http://purl.uniprot.org/uniprot/F6U1N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:DUS4L ^@ http://purl.uniprot.org/uniprot/A0A6I8NTG0 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. http://togogenome.org/gene/9258:P4HA2 ^@ http://purl.uniprot.org/uniprot/A0A6I8NQ75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9258:APOH ^@ http://purl.uniprot.org/uniprot/F7CUR7 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9258:KCNJ2 ^@ http://purl.uniprot.org/uniprot/F7G9G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.|||Membrane http://togogenome.org/gene/9258:ITK ^@ http://purl.uniprot.org/uniprot/F6PFT9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9258:MGST2 ^@ http://purl.uniprot.org/uniprot/F6QVY1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9258:LOC100088430 ^@ http://purl.uniprot.org/uniprot/F7DYH0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:LOC103165823 ^@ http://purl.uniprot.org/uniprot/F7EFU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the resistin/FIZZ family.|||Secreted http://togogenome.org/gene/9258:RIPPLY3 ^@ http://purl.uniprot.org/uniprot/A0A6I8N815 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ripply family.|||Nucleus http://togogenome.org/gene/9258:PALMD ^@ http://purl.uniprot.org/uniprot/F6YWJ0 ^@ Similarity ^@ Belongs to the paralemmin family. http://togogenome.org/gene/9258:NPHS2 ^@ http://purl.uniprot.org/uniprot/F6YHB6 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9258:MYCN ^@ http://purl.uniprot.org/uniprot/A0A6I8NLK7 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/9258:MSX1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NIF4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:LHFPL5 ^@ http://purl.uniprot.org/uniprot/A0A6I8MX43 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:ALLC ^@ http://purl.uniprot.org/uniprot/F6VB05 ^@ Function|||Similarity ^@ Belongs to the allantoicase family.|||The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals. http://togogenome.org/gene/9258:NEU2 ^@ http://purl.uniprot.org/uniprot/F7BZE1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/9258:LOC100091819 ^@ http://purl.uniprot.org/uniprot/A0A6I8N9G3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:EMC8 ^@ http://purl.uniprot.org/uniprot/A0A6I8PEL9 ^@ Similarity ^@ Belongs to the EMC8/EMC9 family. http://togogenome.org/gene/9258:AVPR2 ^@ http://purl.uniprot.org/uniprot/F6W1Z9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.|||Membrane http://togogenome.org/gene/9258:PTGFR ^@ http://purl.uniprot.org/uniprot/F7DVX1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9258:GTF2A1 ^@ http://purl.uniprot.org/uniprot/A0A6I8MX82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 1 family.|||Nucleus http://togogenome.org/gene/9258:FABP2 ^@ http://purl.uniprot.org/uniprot/F7AEJ8 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9258:IPO7 ^@ http://purl.uniprot.org/uniprot/F6XW40 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9258:TIGD4 ^@ http://purl.uniprot.org/uniprot/A0A6I8PIR4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:C5H1orf158 ^@ http://purl.uniprot.org/uniprot/A0A6I8N3A4|||http://purl.uniprot.org/uniprot/A0A6I8NNV1 ^@ Function|||Subcellular Location Annotation ^@ Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.|||cilium axoneme http://togogenome.org/gene/9258:TIMM8A ^@ http://purl.uniprot.org/uniprot/F7BKU7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9258:MARVELD1 ^@ http://purl.uniprot.org/uniprot/F7EZU5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:KCNJ16 ^@ http://purl.uniprot.org/uniprot/F7G9G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9258:STT3B ^@ http://purl.uniprot.org/uniprot/F7BCX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/9258:APOA1 ^@ http://purl.uniprot.org/uniprot/A0A6I8PHD4 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9258:GOLT1A ^@ http://purl.uniprot.org/uniprot/F7BYP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/9258:TLL1 ^@ http://purl.uniprot.org/uniprot/F6WCA9 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9258:B3GALT1 ^@ http://purl.uniprot.org/uniprot/F7BPY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9258:OTULINL ^@ http://purl.uniprot.org/uniprot/A0A6I8NDP8|||http://purl.uniprot.org/uniprot/F6YHS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C65 family. Otulin subfamily.|||Cytoplasm http://togogenome.org/gene/9258:KEF28_p03 ^@ http://purl.uniprot.org/uniprot/Q36459 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 5 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane http://togogenome.org/gene/9258:SHMT1 ^@ http://purl.uniprot.org/uniprot/K7EA77 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/9258:PSMA6 ^@ http://purl.uniprot.org/uniprot/F7C9K3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9258:PROK1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NRX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/9258:TTR ^@ http://purl.uniprot.org/uniprot/F7B925 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transthyretin family.|||Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.|||Secreted|||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. http://togogenome.org/gene/9258:ORAN-DRA ^@ http://purl.uniprot.org/uniprot/A7X5M6 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9258:NADSYN1 ^@ http://purl.uniprot.org/uniprot/F7DFI1 ^@ Similarity|||Subunit ^@ Homohexamer.|||In the C-terminal section; belongs to the NAD synthetase family. http://togogenome.org/gene/9258:LOC100077093 ^@ http://purl.uniprot.org/uniprot/F7EPH9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIIc family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9258:RTN4IP1 ^@ http://purl.uniprot.org/uniprot/F7A3N2 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9258:SLC17A6 ^@ http://purl.uniprot.org/uniprot/F6T3N3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:AKAP4 ^@ http://purl.uniprot.org/uniprot/A0A6I8N3M6 ^@ Similarity ^@ Belongs to the AKAP110 family. http://togogenome.org/gene/9258:PCK1 ^@ http://purl.uniprot.org/uniprot/F7EZR3 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. http://togogenome.org/gene/9258:KARS1 ^@ http://purl.uniprot.org/uniprot/A0A6I8N327 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9258:MC5R ^@ http://purl.uniprot.org/uniprot/F6SQY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins. http://togogenome.org/gene/9258:LOC100093323 ^@ http://purl.uniprot.org/uniprot/A0A6I8N139 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:MRPS25 ^@ http://purl.uniprot.org/uniprot/F7ANY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS25 family.|||Mitochondrion http://togogenome.org/gene/9258:SGMS2 ^@ http://purl.uniprot.org/uniprot/A0A6I8NHQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9258:NXPE3 ^@ http://purl.uniprot.org/uniprot/A0A6I8P098 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/9258:TCEA1 ^@ http://purl.uniprot.org/uniprot/F7BX76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/9258:ORNANAV1R3013 ^@ http://purl.uniprot.org/uniprot/F6RJC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:RTN1 ^@ http://purl.uniprot.org/uniprot/A0A6I8N3Z9|||http://purl.uniprot.org/uniprot/A0A6I8PGW7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9258:BDH1 ^@ http://purl.uniprot.org/uniprot/A0A6I8MYV8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9258:CLRN1 ^@ http://purl.uniprot.org/uniprot/A0A6I8PK10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9258:CENPL ^@ http://purl.uniprot.org/uniprot/F6QG26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-L/IML3 family.|||Nucleus http://togogenome.org/gene/9258:IFT20 ^@ http://purl.uniprot.org/uniprot/F7FPP0 ^@ Subcellular Location Annotation ^@ centriole|||cilium|||cis-Golgi network http://togogenome.org/gene/9258:ORNANAV1R3113 ^@ http://purl.uniprot.org/uniprot/F7BE96 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9258:CD53 ^@ http://purl.uniprot.org/uniprot/F6VK90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9258:SCARB1 ^@ http://purl.uniprot.org/uniprot/A0A6I8N6U1|||http://purl.uniprot.org/uniprot/F7F3F3 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/9258:ORNANAV1R3109 ^@ http://purl.uniprot.org/uniprot/A0A6I8NLG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100093161 ^@ http://purl.uniprot.org/uniprot/A0A6I8PD60 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:LOC100093250 ^@ http://purl.uniprot.org/uniprot/F6PX78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:TAZ ^@ http://purl.uniprot.org/uniprot/F7AYJ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.|||Associates with multiple protein complexes.|||Belongs to the taffazin family.|||Mitochondrion inner membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9258:GNG10 ^@ http://purl.uniprot.org/uniprot/A0A6I8NGF2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9258:FN3K ^@ http://purl.uniprot.org/uniprot/A0A6I8NEV8 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/9258:ORNANAV1R3189 ^@ http://purl.uniprot.org/uniprot/A0A6I8NG84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100083398 ^@ http://purl.uniprot.org/uniprot/A0A6I8N5U0|||http://purl.uniprot.org/uniprot/F7FCB8 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/9258:MEF2C ^@ http://purl.uniprot.org/uniprot/A0A6I8NL35|||http://purl.uniprot.org/uniprot/F7FK52 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:SDR42E1 ^@ http://purl.uniprot.org/uniprot/F7GEN9 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9258:R3HDML ^@ http://purl.uniprot.org/uniprot/F6UAZ5 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/9258:SLC13A1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NU30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9258:POMGNT2 ^@ http://purl.uniprot.org/uniprot/F6TKM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 61 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9258:CHST11 ^@ http://purl.uniprot.org/uniprot/A0A6I8P6U8|||http://purl.uniprot.org/uniprot/A0A6I8PAN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9258:TRPC3 ^@ http://purl.uniprot.org/uniprot/F6XTG1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:TIMM22 ^@ http://purl.uniprot.org/uniprot/A0A6I8NBR4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM22 complex.|||Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9258:ANO3 ^@ http://purl.uniprot.org/uniprot/F6T3H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:FKTN ^@ http://purl.uniprot.org/uniprot/A0A6I8PNJ9 ^@ Similarity ^@ Belongs to the LicD transferase family. http://togogenome.org/gene/9258:KEF28_p08 ^@ http://purl.uniprot.org/uniprot/Q36454 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase A chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with DNAJC30; interaction is direct (By similarity).|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/9258:LOC100093337 ^@ http://purl.uniprot.org/uniprot/F7DNX4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:LOC103168757 ^@ http://purl.uniprot.org/uniprot/F6SDR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/9258:ABI1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NI41|||http://purl.uniprot.org/uniprot/A0A6I8P3V9|||http://purl.uniprot.org/uniprot/F6RH58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9258:USP30 ^@ http://purl.uniprot.org/uniprot/F7G2Z6 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9258:LIX1 ^@ http://purl.uniprot.org/uniprot/A0A6I8PIK6 ^@ Similarity ^@ Belongs to the LIX1 family. http://togogenome.org/gene/9258:STX7 ^@ http://purl.uniprot.org/uniprot/F7E0A0 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9258:CUEDC2 ^@ http://purl.uniprot.org/uniprot/F6TTC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUEDC2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9258:KXD1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NNZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KXD1 family.|||Lysosome membrane http://togogenome.org/gene/9258:CALB2 ^@ http://purl.uniprot.org/uniprot/F6QAK7 ^@ Function|||Similarity ^@ Belongs to the calbindin family.|||Calretinin is a calcium-binding protein which is abundant in auditory neurons. http://togogenome.org/gene/9258:PEMT ^@ http://purl.uniprot.org/uniprot/F7G965|||http://purl.uniprot.org/uniprot/K7EE81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.|||Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9258:UPP1 ^@ http://purl.uniprot.org/uniprot/F6YMY1 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. http://togogenome.org/gene/9258:LOC100079085 ^@ http://purl.uniprot.org/uniprot/A0A6I8PGD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Nucleus http://togogenome.org/gene/9258:TMED6 ^@ http://purl.uniprot.org/uniprot/F6TLX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9258:RPL24 ^@ http://purl.uniprot.org/uniprot/F6PPT9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/9258:SMAD9 ^@ http://purl.uniprot.org/uniprot/F6Y0Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9258:TRAF6 ^@ http://purl.uniprot.org/uniprot/F6S636 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family. A subfamily.|||Lipid droplet|||Nucleus|||cell cortex http://togogenome.org/gene/9258:HOPX ^@ http://purl.uniprot.org/uniprot/A0A6I8N5T3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:VOPP1 ^@ http://purl.uniprot.org/uniprot/F6T8H8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VOPP1/ECOP family.|||Cytoplasmic vesicle membrane|||Endosome membrane|||Interacts with WWOX (via WW domain).|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9258:LOC103170948 ^@ http://purl.uniprot.org/uniprot/F7DZT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100078875 ^@ http://purl.uniprot.org/uniprot/F7F710 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9258:ZDHHC13 ^@ http://purl.uniprot.org/uniprot/F7DFK1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Cytoplasmic vesicle membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9258:TSHB ^@ http://purl.uniprot.org/uniprot/F7FHX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9258:RPS13 ^@ http://purl.uniprot.org/uniprot/F6VCQ3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/9258:GGACT ^@ http://purl.uniprot.org/uniprot/F7D438 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family.|||Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. http://togogenome.org/gene/9258:BRINP2 ^@ http://purl.uniprot.org/uniprot/F7CDU2 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9258:NTSR1 ^@ http://purl.uniprot.org/uniprot/F7DIF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:SEMA3C ^@ http://purl.uniprot.org/uniprot/A0A6I8NJ34 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9258:LOC100089477 ^@ http://purl.uniprot.org/uniprot/F7CZD2 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9258:BRINP1 ^@ http://purl.uniprot.org/uniprot/F6PG64 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9258:ARL3 ^@ http://purl.uniprot.org/uniprot/F7D0F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/9258:NSMCE2 ^@ http://purl.uniprot.org/uniprot/A0A6I8P9B6|||http://purl.uniprot.org/uniprot/F6WLQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NSE2 family.|||Nucleus http://togogenome.org/gene/9258:ATP2C2 ^@ http://purl.uniprot.org/uniprot/F7G926 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9258:UCMA ^@ http://purl.uniprot.org/uniprot/F6UFG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UCMA family.|||May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.|||extracellular matrix http://togogenome.org/gene/9258:CALHM2 ^@ http://purl.uniprot.org/uniprot/A0A6I8P834 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9258:HSDL1 ^@ http://purl.uniprot.org/uniprot/F6SBK8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9258:LOC100082460 ^@ http://purl.uniprot.org/uniprot/A0A6I8NVX6|||http://purl.uniprot.org/uniprot/A0A6I8P044|||http://purl.uniprot.org/uniprot/F6X178 ^@ Similarity ^@ Belongs to the PTEN phosphatase protein family. http://togogenome.org/gene/9258:ACSL5 ^@ http://purl.uniprot.org/uniprot/F7F8D8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9258:LOC100076673 ^@ http://purl.uniprot.org/uniprot/F6VIH9 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9258:LOC100681852 ^@ http://purl.uniprot.org/uniprot/F6UMQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LYZ ^@ http://purl.uniprot.org/uniprot/F7CJ99 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9258:GJA3 ^@ http://purl.uniprot.org/uniprot/A0A6I8N3H2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9258:RPL36 ^@ http://purl.uniprot.org/uniprot/F7GCM1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/9258:SLC31A1 ^@ http://purl.uniprot.org/uniprot/F7ALW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9258:TMEM184A ^@ http://purl.uniprot.org/uniprot/F6QPD0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:GINS4 ^@ http://purl.uniprot.org/uniprot/F6XB21 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS4/SLD5 family.|||Chromosome|||Nucleus|||Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/9258:LOC103165286 ^@ http://purl.uniprot.org/uniprot/F6U6X6 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.|||Lysosome|||Monomer. Interacts with MEFV.|||Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted|||cytosol|||extracellular exosome http://togogenome.org/gene/9258:ORNANAV1R3170 ^@ http://purl.uniprot.org/uniprot/A0A6I8PJQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:STMN1 ^@ http://purl.uniprot.org/uniprot/F7F009 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9258:TFAP2A ^@ http://purl.uniprot.org/uniprot/A0A6I8NVS6|||http://purl.uniprot.org/uniprot/F6XY74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AP-2 family.|||Nucleus http://togogenome.org/gene/9258:SAMD8 ^@ http://purl.uniprot.org/uniprot/F6QNA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9258:LOC100083762 ^@ http://purl.uniprot.org/uniprot/A0A6I8NP18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:NPY2R ^@ http://purl.uniprot.org/uniprot/F7EXP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:TMSB4X ^@ http://purl.uniprot.org/uniprot/A0A6I8NUH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9258:MARK1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NG83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9258:ODR4 ^@ http://purl.uniprot.org/uniprot/A0A6I8NHZ0 ^@ Function|||Similarity ^@ Belongs to the ODR-4 family.|||May play a role in the trafficking of a subset of G-protein coupled receptors. http://togogenome.org/gene/9258:CPLX1 ^@ http://purl.uniprot.org/uniprot/F7C7B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9258:HOXB9 ^@ http://purl.uniprot.org/uniprot/F7BDQ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/9258:CLDN3 ^@ http://purl.uniprot.org/uniprot/F7FSX7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the claudin family.|||Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9258:CALB1 ^@ http://purl.uniprot.org/uniprot/F7E5Y5 ^@ Function|||Similarity ^@ Belongs to the calbindin family.|||Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. http://togogenome.org/gene/9258:CCN4 ^@ http://purl.uniprot.org/uniprot/F6UH66 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9258:PPP2R5E ^@ http://purl.uniprot.org/uniprot/F7G755 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9258:MIF ^@ http://purl.uniprot.org/uniprot/F7DCF9 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/9258:ORNANAV1R3194 ^@ http://purl.uniprot.org/uniprot/A0A6I8N3G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100082203 ^@ http://purl.uniprot.org/uniprot/F7GA85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:ACKR4 ^@ http://purl.uniprot.org/uniprot/F6X8W5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9258:PSMB5 ^@ http://purl.uniprot.org/uniprot/F7ECF7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9258:LOC100079187 ^@ http://purl.uniprot.org/uniprot/F7D5Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/9258:WDR83OS ^@ http://purl.uniprot.org/uniprot/F7AU57 ^@ Similarity ^@ Belongs to the Asterix family. http://togogenome.org/gene/9258:CFTR ^@ http://purl.uniprot.org/uniprot/Q07DZ6 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.|||Binds and hydrolyzes ATP via the two cytoplasmic ABC transporter nucleotide-binding domains. The two ATP-binding domains interact with each other, forming a head-to-tail dimer. Normal ATPase activity requires interaction between the two domains. The first ABC transporter nucleotide-binding domain has no ATPase activity by itself.|||Cell membrane|||Early endosome membrane|||Endoplasmic reticulum membrane|||Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).|||Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation (By similarity).|||N-glycosylated.|||Nucleus|||Phosphorylated; cAMP treatment promotes phosphorylation and activates the channel. Dephosphorylation decreases the ATPase activity (in vitro). Phosphorylation at PKA sites activates the channel. Phosphorylation at PKC sites enhances the response to phosphorylation by PKA. Phosphorylated by AMPK; this inhibits channel activity.|||Recycling endosome membrane|||The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, NHERF1/EBP50 complex.|||The disordered R region mediates channel activation when it is phosphorylated, but not in the absence of phosphorylation.|||Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes enhances its endocytic recycling to the cell membrane. Ubiquitinated by RNF185 during ER stress. Ubiquitinated by MARCHF2 (By similarity). http://togogenome.org/gene/9258:MED18 ^@ http://purl.uniprot.org/uniprot/A0A6I8NAH9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 18 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9258:RORB ^@ http://purl.uniprot.org/uniprot/A0A6I8NZX3|||http://purl.uniprot.org/uniprot/F6S706 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9258:MRPL42 ^@ http://purl.uniprot.org/uniprot/F6VUI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL42 family.|||Mitochondrion http://togogenome.org/gene/9258:TP53I11 ^@ http://purl.uniprot.org/uniprot/A0A6I8NMH1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:TOR1AIP2 ^@ http://purl.uniprot.org/uniprot/A0A6I8PCP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TOR1AIP family.|||Membrane http://togogenome.org/gene/9258:DPH5 ^@ http://purl.uniprot.org/uniprot/F6Q8D4 ^@ Function|||Similarity ^@ Belongs to the diphthine synthase family.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/9258:FNIP1 ^@ http://purl.uniprot.org/uniprot/F7G6V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNIP family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9258:AKAP5 ^@ http://purl.uniprot.org/uniprot/F7B741 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:PTER ^@ http://purl.uniprot.org/uniprot/A0A6I8NMN6 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.|||Binds 2 divalent metal cations per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9258:LOC100085933 ^@ http://purl.uniprot.org/uniprot/A0A6I8PEY6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:RPL11 ^@ http://purl.uniprot.org/uniprot/F7EFX6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL5 family. http://togogenome.org/gene/9258:MAU2 ^@ http://purl.uniprot.org/uniprot/F7FZT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCC4/mau-2 family.|||nucleoplasm http://togogenome.org/gene/9258:PLP1 ^@ http://purl.uniprot.org/uniprot/A0A6I8N089 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9258:COPG2 ^@ http://purl.uniprot.org/uniprot/F6YKB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9258:LOC100682153 ^@ http://purl.uniprot.org/uniprot/F6QKB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:PABPC1 ^@ http://purl.uniprot.org/uniprot/F6XVK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/9258:LOC100073534 ^@ http://purl.uniprot.org/uniprot/F7CIV4 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9258:CDK8 ^@ http://purl.uniprot.org/uniprot/A0A6I8PEA9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9258:PDGFC ^@ http://purl.uniprot.org/uniprot/A0A6I8NXK0 ^@ Caution|||Similarity ^@ Belongs to the PDGF/VEGF growth factor family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9258:ERG ^@ http://purl.uniprot.org/uniprot/A0A6I8NZT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9258:LOC100076913 ^@ http://purl.uniprot.org/uniprot/A0A6I8PF82 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:THUMPD3 ^@ http://purl.uniprot.org/uniprot/F6WCE9 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9258:LOC100083109 ^@ http://purl.uniprot.org/uniprot/F7GAE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:SYT1 ^@ http://purl.uniprot.org/uniprot/A0A6I8PE80 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||synaptic vesicle membrane http://togogenome.org/gene/9258:NKAIN4 ^@ http://purl.uniprot.org/uniprot/F7DEW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:MRPS10 ^@ http://purl.uniprot.org/uniprot/A0A6I8PPZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS10 family.|||Mitochondrion http://togogenome.org/gene/9258:LOC100074669 ^@ http://purl.uniprot.org/uniprot/F6T146 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 6c family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9258:ATXN3 ^@ http://purl.uniprot.org/uniprot/A0A6I8P6I7|||http://purl.uniprot.org/uniprot/A0A6I8P6W3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:NSG2 ^@ http://purl.uniprot.org/uniprot/F7C8F3 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/9258:CDH18 ^@ http://purl.uniprot.org/uniprot/F6VFP8 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100681801 ^@ http://purl.uniprot.org/uniprot/F7G5R3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100093148 ^@ http://purl.uniprot.org/uniprot/A0A6I8PF82 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:TVP23B ^@ http://purl.uniprot.org/uniprot/A0A6I8NHA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/9258:DKK4 ^@ http://purl.uniprot.org/uniprot/F7CGZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9258:KCNJ3 ^@ http://purl.uniprot.org/uniprot/A0A6I8NVL3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.|||Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.|||Membrane|||This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. http://togogenome.org/gene/9258:OVOL1 ^@ http://purl.uniprot.org/uniprot/A0A6I8PIN9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:PRDM1 ^@ http://purl.uniprot.org/uniprot/A0A6I8PJN5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.|||Nucleus|||Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. http://togogenome.org/gene/9258:ARL6 ^@ http://purl.uniprot.org/uniprot/A0A6I8NYD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||cilium membrane http://togogenome.org/gene/9258:PAM16 ^@ http://purl.uniprot.org/uniprot/F6ZIB8 ^@ Similarity ^@ Belongs to the TIM16/PAM16 family. http://togogenome.org/gene/9258:ALDH1A1 ^@ http://purl.uniprot.org/uniprot/F6T2M0 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9258:PELI1 ^@ http://purl.uniprot.org/uniprot/F7DJM8 ^@ Function|||Similarity ^@ Belongs to the pellino family.|||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. http://togogenome.org/gene/9258:GJB2 ^@ http://purl.uniprot.org/uniprot/F7ETY3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9258:ALAS1 ^@ http://purl.uniprot.org/uniprot/F7BXN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/9258:GPX8 ^@ http://purl.uniprot.org/uniprot/F7BT71 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9258:HOXA7 ^@ http://purl.uniprot.org/uniprot/A0A6I8P3C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9258:GSX1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NQM0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:ANXA1 ^@ http://purl.uniprot.org/uniprot/A0A6I8N6Y6|||http://purl.uniprot.org/uniprot/F6T207 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the annexin family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Nucleus|||The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.|||cilium|||extracellular exosome|||extracellular space|||phagocytic cup|||secretory vesicle lumen http://togogenome.org/gene/9258:MED17 ^@ http://purl.uniprot.org/uniprot/K7EEF2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 17 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9258:DOCK2 ^@ http://purl.uniprot.org/uniprot/F6Y0N2 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9258:BPNT1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NC13|||http://purl.uniprot.org/uniprot/F7GEC3 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9258:S1PR1 ^@ http://purl.uniprot.org/uniprot/F6ZG05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:EIF3L ^@ http://purl.uniprot.org/uniprot/F6Z936 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit L family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/9258:KCNU1 ^@ http://purl.uniprot.org/uniprot/F7F3A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.|||Membrane http://togogenome.org/gene/9258:PPIB ^@ http://purl.uniprot.org/uniprot/F7DYN1 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9258:E2F8 ^@ http://purl.uniprot.org/uniprot/F7DFN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9258:LAMTOR4 ^@ http://purl.uniprot.org/uniprot/K7E914 ^@ Similarity ^@ Belongs to the LAMTOR4 family. http://togogenome.org/gene/9258:CTPS2 ^@ http://purl.uniprot.org/uniprot/A0A6I8N6X5|||http://purl.uniprot.org/uniprot/K7EHT6 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/9258:YWHAZ ^@ http://purl.uniprot.org/uniprot/A0A6I8NI84 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9258:IL26 ^@ http://purl.uniprot.org/uniprot/F6PQV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9258:AFG1L ^@ http://purl.uniprot.org/uniprot/F6WT91 ^@ Similarity ^@ Belongs to the AFG1 ATPase family. http://togogenome.org/gene/9258:LOC100083945 ^@ http://purl.uniprot.org/uniprot/A0A6I8NC23|||http://purl.uniprot.org/uniprot/F6Z742 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/9258:HSPA2 ^@ http://purl.uniprot.org/uniprot/F6ZXI7 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9258:UPF1 ^@ http://purl.uniprot.org/uniprot/F7E547 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family.|||Cytoplasm http://togogenome.org/gene/9258:LOC100088038 ^@ http://purl.uniprot.org/uniprot/F7FPB8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9258:LSM6 ^@ http://purl.uniprot.org/uniprot/A0A6I8P8S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/9258:SIRT4 ^@ http://purl.uniprot.org/uniprot/F7A153 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant.|||Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion.|||Belongs to the sirtuin family. Class II subfamily.|||Binds 1 zinc ion per subunit.|||Interacts with GLUD1, IDE and SLC25A5. Interacts with DLAT and PDHX.|||Mitochondrion matrix http://togogenome.org/gene/9258:LOC100090511 ^@ http://purl.uniprot.org/uniprot/F6UWZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:IFN3 ^@ http://purl.uniprot.org/uniprot/A8E6D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9258:ATP6V1C2 ^@ http://purl.uniprot.org/uniprot/A0A6I8P6X8|||http://purl.uniprot.org/uniprot/A0A6I8PMY6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/9258:SERPINI1 ^@ http://purl.uniprot.org/uniprot/F7CJ66 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9258:IL15 ^@ http://purl.uniprot.org/uniprot/A0A6I8PI77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/9258:RPGRIP1L ^@ http://purl.uniprot.org/uniprot/F7D409 ^@ Similarity ^@ Belongs to the RPGRIP1 family. http://togogenome.org/gene/9258:SH3GL2 ^@ http://purl.uniprot.org/uniprot/F6VBU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Membrane http://togogenome.org/gene/9258:ADD3 ^@ http://purl.uniprot.org/uniprot/A0A6I8NBA3 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/9258:STMN3 ^@ http://purl.uniprot.org/uniprot/F7E2A0 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9258:SEC13 ^@ http://purl.uniprot.org/uniprot/F7GBF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Lysosome membrane http://togogenome.org/gene/9258:TMEM159 ^@ http://purl.uniprot.org/uniprot/F6R151 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LDAF1 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Membrane http://togogenome.org/gene/9258:LOC100076505 ^@ http://purl.uniprot.org/uniprot/F6PQB9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aldolase class II family. Adducin subfamily.|||Belongs to the aldolase class II family. MtnB subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.|||Cytoplasm|||Homotetramer. Interacts with APAF1. May interact with CASP1. http://togogenome.org/gene/9258:LOC100088880 ^@ http://purl.uniprot.org/uniprot/F6W4A9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9258:WASF3 ^@ http://purl.uniprot.org/uniprot/F7D261 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9258:ORNANAV1R3127 ^@ http://purl.uniprot.org/uniprot/F7FMP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:SLC16A9 ^@ http://purl.uniprot.org/uniprot/F6WBT5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:SATB1 ^@ http://purl.uniprot.org/uniprot/F7GBA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/9258:LOC100090050 ^@ http://purl.uniprot.org/uniprot/F7ELE1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:ERH ^@ http://purl.uniprot.org/uniprot/A0A6I8NNG7 ^@ Function|||Similarity ^@ Belongs to the E(R) family.|||May have a role in the cell cycle. http://togogenome.org/gene/9258:FGF14 ^@ http://purl.uniprot.org/uniprot/F7CTN6 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9258:ORNANAV1R3265 ^@ http://purl.uniprot.org/uniprot/A0A6I8MYK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100089405 ^@ http://purl.uniprot.org/uniprot/F7BNM6 ^@ Similarity ^@ Belongs to the vasopressin/oxytocin family. http://togogenome.org/gene/9258:LOC100082926 ^@ http://purl.uniprot.org/uniprot/F7CUM3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9258:PPP1CC ^@ http://purl.uniprot.org/uniprot/A0A6I8P341 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-1 subfamily. http://togogenome.org/gene/9258:SLC12A7 ^@ http://purl.uniprot.org/uniprot/A0A6I8P3C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9258:HPRT1 ^@ http://purl.uniprot.org/uniprot/F7AT83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/9258:GBX2 ^@ http://purl.uniprot.org/uniprot/A0A6I8PE44 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:BBS7 ^@ http://purl.uniprot.org/uniprot/F6XU90 ^@ Function|||Subunit ^@ Part of BBSome complex.|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. http://togogenome.org/gene/9258:ORNANAV1R3019 ^@ http://purl.uniprot.org/uniprot/A0A6I8N3K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:B3GNT9 ^@ http://purl.uniprot.org/uniprot/F7G6U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9258:ORNANAV1R3015 ^@ http://purl.uniprot.org/uniprot/F6RJA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:DOCK9 ^@ http://purl.uniprot.org/uniprot/A0A6I8NVP1 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9258:IL1F10 ^@ http://purl.uniprot.org/uniprot/F6U6R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9258:FAM76A ^@ http://purl.uniprot.org/uniprot/A0A6I8NN60 ^@ Similarity ^@ Belongs to the FAM76 family. http://togogenome.org/gene/9258:ITIH2 ^@ http://purl.uniprot.org/uniprot/F6PWM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9258:GEMIN2 ^@ http://purl.uniprot.org/uniprot/F6SYB1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gemin-2 family.|||Cytoplasm|||Part of the core SMN complex.|||The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. http://togogenome.org/gene/9258:UGP2 ^@ http://purl.uniprot.org/uniprot/F7DK07 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Homooctamer.|||UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. http://togogenome.org/gene/9258:PSEN2 ^@ http://purl.uniprot.org/uniprot/F7AD40 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||The PAL motif is required for normal active site conformation. http://togogenome.org/gene/9258:IGF2R ^@ http://purl.uniprot.org/uniprot/Q9N1T0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9258:UCKL1 ^@ http://purl.uniprot.org/uniprot/A0A6I8PBR9|||http://purl.uniprot.org/uniprot/K7EH62 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/9258:KEF28_p01 ^@ http://purl.uniprot.org/uniprot/G8CUI0|||http://purl.uniprot.org/uniprot/Q36461 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b family.|||Binds 2 heme b groups non-covalently.|||Binds 2 heme groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.|||Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.|||Membrane|||Mitochondrion inner membrane|||The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.|||The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools. http://togogenome.org/gene/9258:LOC100083043 ^@ http://purl.uniprot.org/uniprot/A0A6I8N3W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:NDNF ^@ http://purl.uniprot.org/uniprot/F7BV77 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9258:LOC100078234 ^@ http://purl.uniprot.org/uniprot/F6Y2D4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/9258:DKK1 ^@ http://purl.uniprot.org/uniprot/F7G5A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9258:SNAP91 ^@ http://purl.uniprot.org/uniprot/A0A6I8NLX4 ^@ Similarity ^@ Belongs to the PICALM/SNAP91 family. http://togogenome.org/gene/9258:SLC12A4 ^@ http://purl.uniprot.org/uniprot/F6Z596 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9258:FLCN ^@ http://purl.uniprot.org/uniprot/F7G936 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the folliculin family.|||Lysosome membrane|||Membrane|||Nucleus|||centrosome|||cilium|||cytosol|||spindle http://togogenome.org/gene/9258:EPYC ^@ http://purl.uniprot.org/uniprot/F7C656 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/9258:CTU1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NIT2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.|||Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. May form a heterodimer with CTU2/NCS2.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. http://togogenome.org/gene/9258:NPL ^@ http://purl.uniprot.org/uniprot/F6WPI3 ^@ Similarity|||Subunit ^@ Belongs to the DapA family.|||Homotetramer. http://togogenome.org/gene/9258:PLRG1 ^@ http://purl.uniprot.org/uniprot/F7CSR0 ^@ Similarity ^@ Belongs to the WD repeat PRL1/PRL2 family. http://togogenome.org/gene/9258:DIPK2B ^@ http://purl.uniprot.org/uniprot/A0A6I8PQJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/9258:GPC4 ^@ http://purl.uniprot.org/uniprot/F7A1I7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/9258:LOC100076703 ^@ http://purl.uniprot.org/uniprot/A0A6I8NCA1 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9258:SLC25A30 ^@ http://purl.uniprot.org/uniprot/A0A6I8NJ36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9258:CPEB1 ^@ http://purl.uniprot.org/uniprot/F7DY93 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/9258:HSPB3 ^@ http://purl.uniprot.org/uniprot/F7BHG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/9258:LOC100091681 ^@ http://purl.uniprot.org/uniprot/A0A6I8NIA8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9258:LOC100086479 ^@ http://purl.uniprot.org/uniprot/F7EDJ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:LOC100080559 ^@ http://purl.uniprot.org/uniprot/A0A6I8NIV8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRQ/QCR8 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9258:SSBP2 ^@ http://purl.uniprot.org/uniprot/A0A6I8N6N7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:CDSN ^@ http://purl.uniprot.org/uniprot/A7X5Y4 ^@ Function|||Subcellular Location Annotation ^@ Important for the epidermal barrier integrity.|||Secreted http://togogenome.org/gene/9258:CHD9 ^@ http://purl.uniprot.org/uniprot/A0A6I8NAP3 ^@ Similarity ^@ Belongs to the SNF2/RAD54 helicase family. http://togogenome.org/gene/9258:LOC100083024 ^@ http://purl.uniprot.org/uniprot/F7GAI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100083139 ^@ http://purl.uniprot.org/uniprot/F7GA92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:HTR2B ^@ http://purl.uniprot.org/uniprot/F7CYI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||synaptosome http://togogenome.org/gene/9258:CRH ^@ http://purl.uniprot.org/uniprot/F7AJN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/9258:WLS ^@ http://purl.uniprot.org/uniprot/F7CMJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the wntless family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9258:LOC100093301 ^@ http://purl.uniprot.org/uniprot/F7DNX4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:G6PC2 ^@ http://purl.uniprot.org/uniprot/F6XKK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9258:IFNK ^@ http://purl.uniprot.org/uniprot/A8E6D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9258:SGCD ^@ http://purl.uniprot.org/uniprot/F7C7E2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9258:LSM8 ^@ http://purl.uniprot.org/uniprot/A0A6I8P7M6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. http://togogenome.org/gene/9258:MAEL ^@ http://purl.uniprot.org/uniprot/I7AUV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the maelstrom family.|||Nucleus|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage. http://togogenome.org/gene/9258:LOC100087154 ^@ http://purl.uniprot.org/uniprot/F7CK40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100087904 ^@ http://purl.uniprot.org/uniprot/A0A6I8PEV3 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9258:ADIPOR2 ^@ http://purl.uniprot.org/uniprot/F7F368 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9258:CPLX4 ^@ http://purl.uniprot.org/uniprot/F7DHB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9258:CX3CR1 ^@ http://purl.uniprot.org/uniprot/F6S8I2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.|||Membrane http://togogenome.org/gene/9258:LOC100680627 ^@ http://purl.uniprot.org/uniprot/A0A6I8N0T8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:CHRD ^@ http://purl.uniprot.org/uniprot/F7EWG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chordin family.|||Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.|||Secreted http://togogenome.org/gene/9258:GGPS1 ^@ http://purl.uniprot.org/uniprot/F6Z6V4 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9258:NEUROD6 ^@ http://purl.uniprot.org/uniprot/F6YI28 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:ANKS1B ^@ http://purl.uniprot.org/uniprot/A0A6I8NGM2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9258:CCDC172 ^@ http://purl.uniprot.org/uniprot/F7GA98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC172 family.|||Cytoplasm http://togogenome.org/gene/9258:ORC4 ^@ http://purl.uniprot.org/uniprot/F6XN20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC4 family.|||Component of the origin recognition complex (ORC) that binds origins of replication.|||Nucleus http://togogenome.org/gene/9258:RPS24 ^@ http://purl.uniprot.org/uniprot/A0A6I8NL26 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/9258:PLP2 ^@ http://purl.uniprot.org/uniprot/F7FWB7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:HOXA6 ^@ http://purl.uniprot.org/uniprot/F7EBY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9258:SLC10A2 ^@ http://purl.uniprot.org/uniprot/F7GEX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9258:TNFAIP6 ^@ http://purl.uniprot.org/uniprot/A0A6I8NT24 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9258:SMIM12 ^@ http://purl.uniprot.org/uniprot/F6THT1 ^@ Similarity ^@ Belongs to the SMIM12 family. http://togogenome.org/gene/9258:DNAJA4 ^@ http://purl.uniprot.org/uniprot/A0A6I8PAC0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:CALCB ^@ http://purl.uniprot.org/uniprot/A0A6I8NSJ0 ^@ Similarity ^@ Belongs to the calcitonin family. http://togogenome.org/gene/9258:CCNB2 ^@ http://purl.uniprot.org/uniprot/F7DBI2 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9258:YIPF5 ^@ http://purl.uniprot.org/uniprot/F6W544 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/9258:NUDT4 ^@ http://purl.uniprot.org/uniprot/A0A6I8PER4 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/9258:ARG1 ^@ http://purl.uniprot.org/uniprot/F6SK57 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9258:BARX1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NUJ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:LOC100529072 ^@ http://purl.uniprot.org/uniprot/A7X5N1 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9258:ABITRAM ^@ http://purl.uniprot.org/uniprot/F7E8J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABITRAM family.|||growth cone|||lamellipodium http://togogenome.org/gene/9258:LOC100680941 ^@ http://purl.uniprot.org/uniprot/F7G4B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:BIRC7 ^@ http://purl.uniprot.org/uniprot/K7E8R5 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/9258:EHF ^@ http://purl.uniprot.org/uniprot/A0A6I8NHK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9258:PRKCQ ^@ http://purl.uniprot.org/uniprot/F6PVR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/9258:IL5 ^@ http://purl.uniprot.org/uniprot/A0A6I8P6S9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-5 family.|||Homodimer; disulfide-linked.|||Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.|||Secreted http://togogenome.org/gene/9258:KITLG ^@ http://purl.uniprot.org/uniprot/A0A6I8NLQ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCF family.|||Cytoplasm|||Homodimer, non-covalently linked.|||Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.|||Secreted|||filopodium|||lamellipodium http://togogenome.org/gene/9258:SLC17A9 ^@ http://purl.uniprot.org/uniprot/A0A6I8PKM2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:POLR2H ^@ http://purl.uniprot.org/uniprot/A0A6I8N3L3 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RPB8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/9258:ORNANAV1R3162 ^@ http://purl.uniprot.org/uniprot/A0A6I8MZT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100077905 ^@ http://purl.uniprot.org/uniprot/F7F417 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9258:KCNJ13 ^@ http://purl.uniprot.org/uniprot/F7BZF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9258:VAPB ^@ http://purl.uniprot.org/uniprot/A0A6I8NTW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9258:UTP25 ^@ http://purl.uniprot.org/uniprot/F7CDG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP25 family.|||nucleolus http://togogenome.org/gene/9258:CHMP4C ^@ http://purl.uniprot.org/uniprot/F7G5G6 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9258:ETFRF1 ^@ http://purl.uniprot.org/uniprot/F7FN02 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9258:RPL17 ^@ http://purl.uniprot.org/uniprot/F7BUN9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9258:LOC100077007 ^@ http://purl.uniprot.org/uniprot/F7GEM4 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/9258:CMBL ^@ http://purl.uniprot.org/uniprot/F6Z9U4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/9258:LOC100079007 ^@ http://purl.uniprot.org/uniprot/F7B2W9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9258:LOC100077291 ^@ http://purl.uniprot.org/uniprot/A0A6I8MZN6|||http://purl.uniprot.org/uniprot/F6WS06 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/9258:PPM1A ^@ http://purl.uniprot.org/uniprot/F6ZZ09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/9258:CD99 ^@ http://purl.uniprot.org/uniprot/A0A6I8NVW1 ^@ Similarity ^@ Belongs to the CD99 family. http://togogenome.org/gene/9258:PSMB8 ^@ http://purl.uniprot.org/uniprot/A7X5P0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9258:TMEM45B ^@ http://purl.uniprot.org/uniprot/F7FBF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9258:IDO1 ^@ http://purl.uniprot.org/uniprot/B3Y9H6 ^@ Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family. http://togogenome.org/gene/9258:RPL32 ^@ http://purl.uniprot.org/uniprot/A0A6I8P6I6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/9258:OXT ^@ http://purl.uniprot.org/uniprot/F7BNK7 ^@ Similarity ^@ Belongs to the vasopressin/oxytocin family. http://togogenome.org/gene/9258:GTPBP3 ^@ http://purl.uniprot.org/uniprot/F7FGZ6 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. http://togogenome.org/gene/9258:SPO11 ^@ http://purl.uniprot.org/uniprot/A0A6I8PG29 ^@ Similarity ^@ Belongs to the TOP6A family. http://togogenome.org/gene/9258:KEF28_p04 ^@ http://purl.uniprot.org/uniprot/A0A6Q7HQX5|||http://purl.uniprot.org/uniprot/Q36458 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/9258:PTPN14 ^@ http://purl.uniprot.org/uniprot/F6WMM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/9258:SLC16A1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NF12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9258:ORNANAV1R3061 ^@ http://purl.uniprot.org/uniprot/A0A6I8NAD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:SST ^@ http://purl.uniprot.org/uniprot/F6XMG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/9258:SRP9 ^@ http://purl.uniprot.org/uniprot/A0A6I8N7Y2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP9 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm http://togogenome.org/gene/9258:LOC100093370 ^@ http://purl.uniprot.org/uniprot/F7DNX4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:ARHGEF6 ^@ http://purl.uniprot.org/uniprot/F6RAG9 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/9258:LOC100085529 ^@ http://purl.uniprot.org/uniprot/A0A6I8P024 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9258:C1D ^@ http://purl.uniprot.org/uniprot/A0A6I8NFX3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the C1D family.|||Cytoplasm|||Monomer and homodimer.|||Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.|||nucleolus http://togogenome.org/gene/9258:LOC100084369 ^@ http://purl.uniprot.org/uniprot/F7CAQ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/9258:CA3 ^@ http://purl.uniprot.org/uniprot/F7BGY6 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9258:RER1 ^@ http://purl.uniprot.org/uniprot/F7G589 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RER1 family.|||Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.|||Membrane http://togogenome.org/gene/9258:C3H10orf53 ^@ http://purl.uniprot.org/uniprot/F6Z7Q6 ^@ Similarity ^@ Belongs to the UPF0728 family. http://togogenome.org/gene/9258:ALX1 ^@ http://purl.uniprot.org/uniprot/F6Y859 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:G6PD ^@ http://purl.uniprot.org/uniprot/A0A6I8PJK2 ^@ Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. http://togogenome.org/gene/9258:LOC100093165 ^@ http://purl.uniprot.org/uniprot/F6QTF3 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:CNOT2 ^@ http://purl.uniprot.org/uniprot/A0A6I8PGC9 ^@ Similarity ^@ Belongs to the CNOT2/3/5 family. http://togogenome.org/gene/9258:LOC100093308 ^@ http://purl.uniprot.org/uniprot/A0A6I8N7N1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:SURF4 ^@ http://purl.uniprot.org/uniprot/A0A6I8NH26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9258:LOC100085065 ^@ http://purl.uniprot.org/uniprot/F7C0F4 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9258:SNAPC3 ^@ http://purl.uniprot.org/uniprot/F7FE29 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAPC3/SRD2 family.|||Nucleus|||Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.|||Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. http://togogenome.org/gene/9258:SRXN1 ^@ http://purl.uniprot.org/uniprot/A0A6I8PBI0 ^@ Similarity ^@ Belongs to the sulfiredoxin family. http://togogenome.org/gene/9258:LFNG ^@ http://purl.uniprot.org/uniprot/F6SZM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9258:LOC100082293 ^@ http://purl.uniprot.org/uniprot/F7DSP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9258:SEPTIN8 ^@ http://purl.uniprot.org/uniprot/F6YNV3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9258:GPER1 ^@ http://purl.uniprot.org/uniprot/F6TC29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100093170 ^@ http://purl.uniprot.org/uniprot/A0A6I8P814 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:ACP1 ^@ http://purl.uniprot.org/uniprot/A0A6I8PKY2|||http://purl.uniprot.org/uniprot/F6RX59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.|||Belongs to the low molecular weight phosphotyrosine protein phosphatase family.|||Cytoplasm http://togogenome.org/gene/9258:TMEM50A ^@ http://purl.uniprot.org/uniprot/F6SWE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/9258:APPL2 ^@ http://purl.uniprot.org/uniprot/F6RTD8 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Membrane|||Nucleus|||phagosome|||ruffle http://togogenome.org/gene/9258:HTR1F ^@ http://purl.uniprot.org/uniprot/F7EPA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.|||Membrane http://togogenome.org/gene/9258:OPN1MW3 ^@ http://purl.uniprot.org/uniprot/A4ZIT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/9258:LOC100093255 ^@ http://purl.uniprot.org/uniprot/F7CNK4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.|||Cytoplasm|||May play a role during erythropoiesis through regulation of transcription factor DDIT3.|||Nucleus|||nucleolus http://togogenome.org/gene/9258:SLC35F6 ^@ http://purl.uniprot.org/uniprot/F7D6B9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLC35F solute transporter family.|||Interacts with SLC25A5.|||May play a role as a nucleotide-sugar transporter.|||Membrane|||Mitochondrion http://togogenome.org/gene/9258:LOC100087130 ^@ http://purl.uniprot.org/uniprot/P01979 ^@ Function|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the globin family.|||Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.|||Heterotetramer of two alpha chains and two beta chains.|||Involved in oxygen transport from the lung to the various peripheral tissues.|||Red blood cells. http://togogenome.org/gene/9258:FOXL3 ^@ http://purl.uniprot.org/uniprot/F7CXI5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:CLCN4 ^@ http://purl.uniprot.org/uniprot/F6SKL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/9258:HOXD12 ^@ http://purl.uniprot.org/uniprot/F7G0M4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:ASF1B ^@ http://purl.uniprot.org/uniprot/A0A6I8PGW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/9258:LOC100079619 ^@ http://purl.uniprot.org/uniprot/F7EXB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9258:DHX9 ^@ http://purl.uniprot.org/uniprot/F6WPG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DEAH subfamily.|||Nucleus http://togogenome.org/gene/9258:ORNANAV1R3263 ^@ http://purl.uniprot.org/uniprot/A0A6I8MY91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:MC2R ^@ http://purl.uniprot.org/uniprot/F7FM99 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).|||Membrane http://togogenome.org/gene/9258:DAZL ^@ http://purl.uniprot.org/uniprot/F7CS82 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9258:DNAJA1 ^@ http://purl.uniprot.org/uniprot/A0A6I8PND9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:CALHM5 ^@ http://purl.uniprot.org/uniprot/F6URF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9258:PTGS2 ^@ http://purl.uniprot.org/uniprot/A0A6I8P4L4 ^@ Caution|||Similarity ^@ Belongs to the prostaglandin G/H synthase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9258:LOC107547808 ^@ http://purl.uniprot.org/uniprot/F6YN49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:ABL1 ^@ http://purl.uniprot.org/uniprot/A0A6I8PFF6|||http://purl.uniprot.org/uniprot/F6QCG8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9258:ORNANAV1R3264 ^@ http://purl.uniprot.org/uniprot/A0A6I8PB87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:MRPL32 ^@ http://purl.uniprot.org/uniprot/A0A6I8NU47 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/9258:NACC2 ^@ http://purl.uniprot.org/uniprot/F6V793 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:RPL14 ^@ http://purl.uniprot.org/uniprot/A0A6I8PKY3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/9258:POLR2G ^@ http://purl.uniprot.org/uniprot/F6PS64 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9258:TSPAN8 ^@ http://purl.uniprot.org/uniprot/F6SXL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9258:SMAD4 ^@ http://purl.uniprot.org/uniprot/F7F4A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9258:RPL7L1 ^@ http://purl.uniprot.org/uniprot/F6PJ74 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/9258:ACTB ^@ http://purl.uniprot.org/uniprot/F6UDX9 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9258:LOC100076573 ^@ http://purl.uniprot.org/uniprot/A0A6I8NR60 ^@ Similarity ^@ Belongs to the BANP/SMAR1 family. http://togogenome.org/gene/9258:ORNANAV1R3005 ^@ http://purl.uniprot.org/uniprot/F7BJA5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9258:TNFSF10 ^@ http://purl.uniprot.org/uniprot/F7CZ84 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Homotrimer.|||Membrane|||Secreted http://togogenome.org/gene/9258:PWWP3A ^@ http://purl.uniprot.org/uniprot/F7DUZ3 ^@ Similarity ^@ Belongs to the PWWP3A family. http://togogenome.org/gene/9258:MRE11 ^@ http://purl.uniprot.org/uniprot/F6YRG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MRE11/RAD32 family.|||Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.|||Nucleus http://togogenome.org/gene/9258:BRS3 ^@ http://purl.uniprot.org/uniprot/F7BLI7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with C6orf89.|||Membrane http://togogenome.org/gene/9258:LYZL4 ^@ http://purl.uniprot.org/uniprot/F7D6D7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9258:RFLB ^@ http://purl.uniprot.org/uniprot/B1AAR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9258:LOC100074817 ^@ http://purl.uniprot.org/uniprot/F6ZTJ8 ^@ Function|||Similarity ^@ Belongs to the RutC family.|||Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. http://togogenome.org/gene/9258:LOC100092128 ^@ http://purl.uniprot.org/uniprot/F6ST51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:OTUB2 ^@ http://purl.uniprot.org/uniprot/F7DYW4 ^@ Similarity ^@ Belongs to the peptidase C65 family. http://togogenome.org/gene/9258:GINS3 ^@ http://purl.uniprot.org/uniprot/A0A6I8P934 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS3/PSF3 family.|||Chromosome|||Component of the GINS complex.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication. http://togogenome.org/gene/9258:PRPF18 ^@ http://purl.uniprot.org/uniprot/F6VC31|||http://purl.uniprot.org/uniprot/K7ECI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP18 family.|||Nucleus speckle http://togogenome.org/gene/9258:MTX2 ^@ http://purl.uniprot.org/uniprot/F6WME1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9258:PMEPA1 ^@ http://purl.uniprot.org/uniprot/F7ESH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMEPA1 family.|||Early endosome membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9258:NPTX2 ^@ http://purl.uniprot.org/uniprot/F6Z568 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9258:ATP5F1A ^@ http://purl.uniprot.org/uniprot/F6V9Q4 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/9258:SGCG ^@ http://purl.uniprot.org/uniprot/A0A6I8N8U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9258:LOC100081707 ^@ http://purl.uniprot.org/uniprot/F6TVB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:LOC100083188 ^@ http://purl.uniprot.org/uniprot/F7GA82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:ORNANAV1R3268 ^@ http://purl.uniprot.org/uniprot/A0A6I8NGV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:TNFRSF19 ^@ http://purl.uniprot.org/uniprot/A0A6I8NF11 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9258:NDUFA5 ^@ http://purl.uniprot.org/uniprot/F7E2X7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9258:ORNANAV1R3198 ^@ http://purl.uniprot.org/uniprot/F7FME8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100077545 ^@ http://purl.uniprot.org/uniprot/F6Y1I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9258:LSM3 ^@ http://purl.uniprot.org/uniprot/F7DVJ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/9258:MYH11 ^@ http://purl.uniprot.org/uniprot/A0A6I8PB26|||http://purl.uniprot.org/uniprot/F6WFN3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9258:CXCL12 ^@ http://purl.uniprot.org/uniprot/A0A6I8NGE9 ^@ Similarity ^@ Belongs to the intercrine alpha (chemokine CxC) family. http://togogenome.org/gene/9258:OGN ^@ http://purl.uniprot.org/uniprot/F6X320 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/9258:SKA3 ^@ http://purl.uniprot.org/uniprot/A0A6I8PR59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SKA3 family.|||kinetochore|||spindle http://togogenome.org/gene/9258:CTTNBP2 ^@ http://purl.uniprot.org/uniprot/Q07DZ5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.|||Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.|||cell cortex|||dendritic spine http://togogenome.org/gene/9258:ORNANAV1R3020 ^@ http://purl.uniprot.org/uniprot/A0A6I8NKG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:GUCY1A1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NUE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/9258:ORNANAV1R3199 ^@ http://purl.uniprot.org/uniprot/A0A6I8P7Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:URAD ^@ http://purl.uniprot.org/uniprot/F7GDM5 ^@ Function|||Similarity ^@ Belongs to the OHCU decarboxylase family.|||Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin. http://togogenome.org/gene/9258:SEPTIN2 ^@ http://purl.uniprot.org/uniprot/F6T0Y1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cleavage furrow|||Filament-forming cytoskeletal GTPase.|||Midbody|||Septins polymerize into heterooligomeric protein complexes that form filaments.|||cilium membrane|||spindle http://togogenome.org/gene/9258:ERG28 ^@ http://purl.uniprot.org/uniprot/A0A6I8MZB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG28 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9258:S100A4 ^@ http://purl.uniprot.org/uniprot/F6Q7T6 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9258:HADHA ^@ http://purl.uniprot.org/uniprot/A0A6I8NUB2|||http://purl.uniprot.org/uniprot/F7EMK0 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9258:HAPLN1 ^@ http://purl.uniprot.org/uniprot/F7EH86 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9258:FTH1 ^@ http://purl.uniprot.org/uniprot/F7E2N2 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/9258:PDE5A ^@ http://purl.uniprot.org/uniprot/A0A6I8P3Y3 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9258:LOC100074634 ^@ http://purl.uniprot.org/uniprot/F7DIZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-nucleotidase family.|||Membrane http://togogenome.org/gene/9258:SFRP2 ^@ http://purl.uniprot.org/uniprot/A0A6I8PNR4 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9258:LOC100093369 ^@ http://purl.uniprot.org/uniprot/F6PXE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9258:VPS29 ^@ http://purl.uniprot.org/uniprot/A0A6I8P3L8|||http://purl.uniprot.org/uniprot/F7FN67 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.|||Belongs to the VPS29 family.|||Endosome membrane http://togogenome.org/gene/9258:ORNANAV1R3244 ^@ http://purl.uniprot.org/uniprot/A0A6I8NI10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:TRIM32 ^@ http://purl.uniprot.org/uniprot/F6UML6 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/9258:BORCS7 ^@ http://purl.uniprot.org/uniprot/A0A6I8N861|||http://purl.uniprot.org/uniprot/F7D0T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS7 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9258:MAB21L2 ^@ http://purl.uniprot.org/uniprot/F6UKL2 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9258:HNRNPA2B1 ^@ http://purl.uniprot.org/uniprot/F7EJK5 ^@ Subcellular Location Annotation ^@ Cytoplasmic granule http://togogenome.org/gene/9258:TMEM208 ^@ http://purl.uniprot.org/uniprot/A0A6I8PDP1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM208 family.|||Endoplasmic reticulum membrane|||May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.|||Membrane http://togogenome.org/gene/9258:ACVR1 ^@ http://purl.uniprot.org/uniprot/A0A6I8PDF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9258:STRADB ^@ http://purl.uniprot.org/uniprot/K7EI25 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. http://togogenome.org/gene/9258:LYRM1 ^@ http://purl.uniprot.org/uniprot/F6Q5F2 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9258:GNG3 ^@ http://purl.uniprot.org/uniprot/A0A6I8PCY2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9258:TIGD1 ^@ http://purl.uniprot.org/uniprot/F7CP89 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:PORCN ^@ http://purl.uniprot.org/uniprot/A0A6I8NJK4|||http://purl.uniprot.org/uniprot/F6QQ44 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:LIMK2 ^@ http://purl.uniprot.org/uniprot/A0A6I8N2M8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/9258:LOC100082917 ^@ http://purl.uniprot.org/uniprot/F7GAK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:METTL8 ^@ http://purl.uniprot.org/uniprot/F6PIF6 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9258:CTNNBIP1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NZ31 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/9258:SLC20A2 ^@ http://purl.uniprot.org/uniprot/A0A6I8MY49|||http://purl.uniprot.org/uniprot/F6ZED3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/9258:ORNANAV1R3193 ^@ http://purl.uniprot.org/uniprot/A0A6I8P3H6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:CYRIB ^@ http://purl.uniprot.org/uniprot/F7FXY9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CYRI family.|||Interacts with RAC1 (GTP-bound form preferentially).|||Membrane http://togogenome.org/gene/9258:LAMP5 ^@ http://purl.uniprot.org/uniprot/F6VV53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9258:MMAA ^@ http://purl.uniprot.org/uniprot/F6YA49 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/9258:ORNANAV1R3046 ^@ http://purl.uniprot.org/uniprot/A0A6I8N4Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100078431 ^@ http://purl.uniprot.org/uniprot/F7E542 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9258:LOC100080622 ^@ http://purl.uniprot.org/uniprot/A0A6I8PF82 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:BBOX1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NRD9 ^@ Function|||Similarity ^@ Belongs to the gamma-BBH/TMLD family.|||Catalyzes the formation of L-carnitine from gamma-butyrobetaine. http://togogenome.org/gene/9258:COPB1 ^@ http://purl.uniprot.org/uniprot/F7C3B7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Endoplasmic reticulum-Golgi intermediate compartment|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9258:DPYSL3 ^@ http://purl.uniprot.org/uniprot/F7DIK9 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9258:FER ^@ http://purl.uniprot.org/uniprot/F6SAV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.|||Cell membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/9258:GDF2 ^@ http://purl.uniprot.org/uniprot/F6UER7 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9258:ITGA6 ^@ http://purl.uniprot.org/uniprot/F7CBN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9258:GJB3 ^@ http://purl.uniprot.org/uniprot/F6TGG8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9258:ATP5MC3 ^@ http://purl.uniprot.org/uniprot/A0A6I8NEJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9258:PAX1 ^@ http://purl.uniprot.org/uniprot/F6SX13 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:SEMA3D ^@ http://purl.uniprot.org/uniprot/F7AVT1 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9258:MAB21L1 ^@ http://purl.uniprot.org/uniprot/F7B8L8 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9258:LZIC ^@ http://purl.uniprot.org/uniprot/F7EKH8 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/9258:ORNANAV1R3228 ^@ http://purl.uniprot.org/uniprot/A0A6I8NPP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:ANAPC10 ^@ http://purl.uniprot.org/uniprot/F7DUE6 ^@ Function|||Similarity ^@ Belongs to the APC10 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/9258:LOC100083559 ^@ http://purl.uniprot.org/uniprot/F6REZ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Interacts with TTR.|||Retinol-binding protein that mediates retinol transport in blood plasma.|||Secreted http://togogenome.org/gene/9258:CDCA7 ^@ http://purl.uniprot.org/uniprot/F7CB81 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9258:CAV1 ^@ http://purl.uniprot.org/uniprot/Q07E02 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||Homooligomer. Interacts (via the N-terminus) with DPP4; the interaction is direct. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2; this interaction induces membrane tubulation (By similarity). Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9. Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner. Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation. Interacts with ABCG1; this interaction regulates ABCG1-mediated cholesterol efflux (By similarity). Interacts with NEU3; this interaction enhances NEU3 sialidase activity within caveola. Interacts (via C-terminus) with SPRY1, SPRY2 (via C-terminus), SPRY3, and SPRY4 (By similarity).|||May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).|||Membrane raft|||Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.|||Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation. Ubiquitinated by ZNRF1; leading to degradation and modulation of the TLR4-mediated immune response.|||caveola http://togogenome.org/gene/9258:CHRNA1 ^@ http://purl.uniprot.org/uniprot/F6XJA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9258:CDC34 ^@ http://purl.uniprot.org/uniprot/F7F5T2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9258:KEF28_p12 ^@ http://purl.uniprot.org/uniprot/Q36451 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 2 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242 (By similarity).|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane http://togogenome.org/gene/9258:TAP2 ^@ http://purl.uniprot.org/uniprot/A7X5N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.|||Membrane http://togogenome.org/gene/9258:LOC100092015 ^@ http://purl.uniprot.org/uniprot/F6Y184 ^@ Similarity ^@ Belongs to the adenylate kinase family. http://togogenome.org/gene/9258:LHFPL6 ^@ http://purl.uniprot.org/uniprot/F6X1Z4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:LOC100077537 ^@ http://purl.uniprot.org/uniprot/F6PSU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9258:TNFSF8 ^@ http://purl.uniprot.org/uniprot/F7A8A3 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9258:DLK1 ^@ http://purl.uniprot.org/uniprot/B5LY07 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9258:RSAD2 ^@ http://purl.uniprot.org/uniprot/A0A6I8N6S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RSAD2 family.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion inner membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9258:CLCN3 ^@ http://purl.uniprot.org/uniprot/A0A6I8NIL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.|||Cell membrane|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9258:LOC100681347 ^@ http://purl.uniprot.org/uniprot/A0A6I8MZ61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9258:RPL13A ^@ http://purl.uniprot.org/uniprot/F6PKE7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/9258:GPR50 ^@ http://purl.uniprot.org/uniprot/A0A2P1K6N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:RNASE13 ^@ http://purl.uniprot.org/uniprot/F6V3S6 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9258:RAB9A ^@ http://purl.uniprot.org/uniprot/F7E148 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||phagosome membrane http://togogenome.org/gene/9258:BASP1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NDF1 ^@ Similarity ^@ Belongs to the BASP1 family. http://togogenome.org/gene/9258:SFXN1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NMP4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9258:BLOC1S3 ^@ http://purl.uniprot.org/uniprot/F6T469 ^@ Similarity ^@ Belongs to the BLOC1S3 family. http://togogenome.org/gene/9258:ORNANAV1R3220 ^@ http://purl.uniprot.org/uniprot/A0A6I8P4Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:UGT8 ^@ http://purl.uniprot.org/uniprot/A0A6I8PJ24 ^@ Similarity ^@ Belongs to the UDP-glycosyltransferase family. http://togogenome.org/gene/9258:CDR2 ^@ http://purl.uniprot.org/uniprot/A0A6I8P0S9 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/9258:LOC100087008 ^@ http://purl.uniprot.org/uniprot/F6QAR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:TSPAN12 ^@ http://purl.uniprot.org/uniprot/A0A6I8P367 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9258:EDN1 ^@ http://purl.uniprot.org/uniprot/F6WZM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/9258:LOC100078521 ^@ http://purl.uniprot.org/uniprot/F6Z4D6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9258:BCL2A1 ^@ http://purl.uniprot.org/uniprot/F6S8G3 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9258:SF3B3 ^@ http://purl.uniprot.org/uniprot/A0A6I8P9Z8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:KATNAL1 ^@ http://purl.uniprot.org/uniprot/A0A6I8MZY0 ^@ Activity Regulation|||Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||Cytoplasm|||Interacts with KATNB1 and KATNBL1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Midbody|||Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.|||Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.|||The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.|||Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9258:EEF1AKMT1 ^@ http://purl.uniprot.org/uniprot/F7EL08 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.|||Cytoplasm|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.|||Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure. http://togogenome.org/gene/9258:ELK3 ^@ http://purl.uniprot.org/uniprot/A0A6I8N8F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9258:STX19 ^@ http://purl.uniprot.org/uniprot/F7EXD2 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9258:GTF2H2 ^@ http://purl.uniprot.org/uniprot/F7G7T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTF2H2 family.|||Nucleus http://togogenome.org/gene/9258:TLR8 ^@ http://purl.uniprot.org/uniprot/A0A6I8NGX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9258:TMEM267 ^@ http://purl.uniprot.org/uniprot/A0A6I8PML4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:GNGT1 ^@ http://purl.uniprot.org/uniprot/A0A6I8P150 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9258:NUP93 ^@ http://purl.uniprot.org/uniprot/F7F915 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin interacting component (NIC) family.|||Nucleus membrane|||Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.|||nuclear pore complex http://togogenome.org/gene/9258:MB ^@ http://purl.uniprot.org/uniprot/P02196 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. http://togogenome.org/gene/9258:LOC100093280 ^@ http://purl.uniprot.org/uniprot/A0A6I8P814 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:JPT2 ^@ http://purl.uniprot.org/uniprot/A0A6I8NU72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9258:COQ7 ^@ http://purl.uniprot.org/uniprot/K7EG75 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ7 family.|||Binds 2 iron ions per subunit.|||Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.|||Mitochondrion inner membrane http://togogenome.org/gene/9258:ELAC1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NUK4 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/9258:TMEM129 ^@ http://purl.uniprot.org/uniprot/F6TNU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM129 family.|||Membrane http://togogenome.org/gene/9258:KPNA2 ^@ http://purl.uniprot.org/uniprot/F6RK29 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9258:PXMP2 ^@ http://purl.uniprot.org/uniprot/F6ZG20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/9258:LIMS2 ^@ http://purl.uniprot.org/uniprot/A0A6I8NN98|||http://purl.uniprot.org/uniprot/F7G857 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.|||Cell membrane|||Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.|||focal adhesion http://togogenome.org/gene/9258:SPARC ^@ http://purl.uniprot.org/uniprot/F6YAF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.|||Belongs to the SPARC family.|||Membrane|||basement membrane http://togogenome.org/gene/9258:LOC107547714 ^@ http://purl.uniprot.org/uniprot/A0A6I8P819 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9258:LIPG ^@ http://purl.uniprot.org/uniprot/F6VS71 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9258:ARL5B ^@ http://purl.uniprot.org/uniprot/A0A6I8P646 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9258:CNDP1 ^@ http://purl.uniprot.org/uniprot/F7FI95 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9258:MRPL13 ^@ http://purl.uniprot.org/uniprot/F7G4R8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/9258:LOC100077615 ^@ http://purl.uniprot.org/uniprot/F7F337 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYS1 family.|||Golgi apparatus membrane|||Interacts with ARFRP1.|||Involved in protein trafficking. May serve as a receptor for ARFRP1.|||Membrane http://togogenome.org/gene/9258:TNFSF9 ^@ http://purl.uniprot.org/uniprot/A0A6I8NLA5 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9258:ORNANAV1R3067 ^@ http://purl.uniprot.org/uniprot/F7DYA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:ORNANAV1R3181 ^@ http://purl.uniprot.org/uniprot/A0A6I8NYU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:C3H11orf58 ^@ http://purl.uniprot.org/uniprot/A0A6I8PR99 ^@ Similarity ^@ Belongs to the SMAP family. http://togogenome.org/gene/9258:LOC100077475 ^@ http://purl.uniprot.org/uniprot/A0A6I8NRH3 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9258:DCN ^@ http://purl.uniprot.org/uniprot/F7C682 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.|||May affect the rate of fibrils formation.|||extracellular matrix http://togogenome.org/gene/9258:GCNT4 ^@ http://purl.uniprot.org/uniprot/F7FXW1 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9258:DNAJA2 ^@ http://purl.uniprot.org/uniprot/F7AM31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:CZIB ^@ http://purl.uniprot.org/uniprot/F7F239 ^@ Similarity ^@ Belongs to the UPF0587 family. http://togogenome.org/gene/9258:LOC100080393 ^@ http://purl.uniprot.org/uniprot/F7FG77 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:LOC100084359 ^@ http://purl.uniprot.org/uniprot/A0A6I8PI95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:ADRM1 ^@ http://purl.uniprot.org/uniprot/F6VAL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADRM1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9258:BFSP1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NPL3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||cell cortex|||cytoskeleton http://togogenome.org/gene/9258:GNRHR ^@ http://purl.uniprot.org/uniprot/B2BF83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:CAVIN4 ^@ http://purl.uniprot.org/uniprot/F7E8I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9258:ORNANAV1R3053 ^@ http://purl.uniprot.org/uniprot/A0A6I8N3Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:OLFM1 ^@ http://purl.uniprot.org/uniprot/A0A6I8P4Z3 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/9258:EPHA2 ^@ http://purl.uniprot.org/uniprot/F6WYZ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:TSC22D1 ^@ http://purl.uniprot.org/uniprot/F7DRV8 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9258:TAF7L ^@ http://purl.uniprot.org/uniprot/F7BKV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF7 family.|||Nucleus http://togogenome.org/gene/9258:LOC100078019 ^@ http://purl.uniprot.org/uniprot/F6PLK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the leptin family.|||Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells. Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38. In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses. Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation.|||Secreted http://togogenome.org/gene/9258:UGDH ^@ http://purl.uniprot.org/uniprot/F6RM31 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.|||Homohexamer.|||Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. http://togogenome.org/gene/9258:MRPL2 ^@ http://purl.uniprot.org/uniprot/F6QEF8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/9258:NDUFA2 ^@ http://purl.uniprot.org/uniprot/F6RB25 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9258:LOC100681826 ^@ http://purl.uniprot.org/uniprot/F6UMS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:KCNE2 ^@ http://purl.uniprot.org/uniprot/F6ZQI9 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9258:PAFAH1B1 ^@ http://purl.uniprot.org/uniprot/F6PQP7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LIS1/nudF family.|||Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits.|||Dimerization mediated by the LisH domain may be required to activate dynein.|||Nucleus membrane|||Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.|||centrosome|||cytoskeleton|||spindle http://togogenome.org/gene/9258:PIK3CA ^@ http://purl.uniprot.org/uniprot/F7DUD6 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9258:LOC100092796 ^@ http://purl.uniprot.org/uniprot/F7A524 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:SENP7 ^@ http://purl.uniprot.org/uniprot/F6PP50 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9258:SMC5 ^@ http://purl.uniprot.org/uniprot/F7FZ46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC5 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9258:YME1L1 ^@ http://purl.uniprot.org/uniprot/F6QLB9 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/9258:CHRNA4 ^@ http://purl.uniprot.org/uniprot/F7DET6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9258:HMGCS1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NH90 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/9258:SEC61A2 ^@ http://purl.uniprot.org/uniprot/F6UDU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9258:LOC100073952 ^@ http://purl.uniprot.org/uniprot/F6ULR0 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9258:CCT5 ^@ http://purl.uniprot.org/uniprot/F6Z9V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9258:PRR5L ^@ http://purl.uniprot.org/uniprot/F6S652 ^@ Similarity ^@ Belongs to the PROTOR family. http://togogenome.org/gene/9258:CACNA2D1 ^@ http://purl.uniprot.org/uniprot/A0A6I8PGU1|||http://purl.uniprot.org/uniprot/F7FSJ0 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/9258:ORNANAV1R3124 ^@ http://purl.uniprot.org/uniprot/F6SSY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:TSSK2 ^@ http://purl.uniprot.org/uniprot/F7CS33 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9258:OSTC ^@ http://purl.uniprot.org/uniprot/F6XNQ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OSTC family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. http://togogenome.org/gene/9258:PCYOX1L ^@ http://purl.uniprot.org/uniprot/F7FAU5 ^@ Similarity ^@ Belongs to the prenylcysteine oxidase family. http://togogenome.org/gene/9258:NRN1L ^@ http://purl.uniprot.org/uniprot/A0A6I8N569 ^@ Similarity ^@ Belongs to the neuritin family. http://togogenome.org/gene/9258:CSNK2A2 ^@ http://purl.uniprot.org/uniprot/F7F9Q9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9258:GLO1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NKC9 ^@ Cofactor|||Similarity ^@ Belongs to the glyoxalase I family.|||Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits. http://togogenome.org/gene/9258:TTYH3 ^@ http://purl.uniprot.org/uniprot/F6SZA6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tweety family.|||Cell membrane|||Membrane|||Probable chloride channel. http://togogenome.org/gene/9258:TAGLN3 ^@ http://purl.uniprot.org/uniprot/A0A6I8P7A6 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/9258:RBP1 ^@ http://purl.uniprot.org/uniprot/F7ACB8 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9258:SULT1E1 ^@ http://purl.uniprot.org/uniprot/K7E9W5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9258:B3GNT2 ^@ http://purl.uniprot.org/uniprot/F7DKD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9258:MAP2K3 ^@ http://purl.uniprot.org/uniprot/A0A6I8NJZ7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9258:LOC100078901 ^@ http://purl.uniprot.org/uniprot/F7B3E4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9258:KMO ^@ http://purl.uniprot.org/uniprot/F6UAQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aromatic-ring hydroxylase family. KMO subfamily.|||Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.|||Mitochondrion outer membrane http://togogenome.org/gene/9258:LOC103170567 ^@ http://purl.uniprot.org/uniprot/F7EQX0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Homodimer.|||Secreted http://togogenome.org/gene/9258:CDH10 ^@ http://purl.uniprot.org/uniprot/F6VET9 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100090373 ^@ http://purl.uniprot.org/uniprot/A0A6I8N3Y6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9258:NFIB ^@ http://purl.uniprot.org/uniprot/F7FDN2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/9258:ORNANAV1R3094 ^@ http://purl.uniprot.org/uniprot/F6YV37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:TBPL1 ^@ http://purl.uniprot.org/uniprot/F6UVN1 ^@ Similarity|||Subunit ^@ Belongs to the TBP family.|||Binds TFIIA and TFIIB. http://togogenome.org/gene/9258:CNEP1R1 ^@ http://purl.uniprot.org/uniprot/F7F4C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNEP1R1 family.|||Cytoplasm|||Membrane|||Nucleus membrane http://togogenome.org/gene/9258:SLC10A7 ^@ http://purl.uniprot.org/uniprot/A0A6I8NM03|||http://purl.uniprot.org/uniprot/F7C2N0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Cell membrane|||Does not show transport activity towards bile acids or steroid sulfates.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/9258:B3GALT2 ^@ http://purl.uniprot.org/uniprot/F6V488 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9258:ORNANAV1R3112 ^@ http://purl.uniprot.org/uniprot/A0A6I8P1R6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:SCG2 ^@ http://purl.uniprot.org/uniprot/F7ETF5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chromogranin/secretogranin protein family.|||Interacts with Secretogranin III/SCG3.|||Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.|||Secreted http://togogenome.org/gene/9258:MAPK13 ^@ http://purl.uniprot.org/uniprot/F6ZRF3 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Interacts with MAPK8IP2. http://togogenome.org/gene/9258:ORNANAV1R3159 ^@ http://purl.uniprot.org/uniprot/F7APT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:RPL22 ^@ http://purl.uniprot.org/uniprot/A0A6I8PB14 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/9258:CDC37L1 ^@ http://purl.uniprot.org/uniprot/F7DC58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/9258:SULT1A ^@ http://purl.uniprot.org/uniprot/Q95JC5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9258:AIDA ^@ http://purl.uniprot.org/uniprot/F7G8E0 ^@ Similarity ^@ Belongs to the AIDA family. http://togogenome.org/gene/9258:LOC103166461 ^@ http://purl.uniprot.org/uniprot/P0C8A8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the beta-defensin family.|||Has antimicrobial activity.|||Highly expressed in kidney, lowly expressed in spleen, and expressed at lower levels in lung.|||Secreted http://togogenome.org/gene/9258:NME2 ^@ http://purl.uniprot.org/uniprot/F6TWB2 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9258:WNT2 ^@ http://purl.uniprot.org/uniprot/Q07DZ8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).|||Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.|||extracellular matrix http://togogenome.org/gene/9258:BMP7 ^@ http://purl.uniprot.org/uniprot/F7EZU0 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9258:IFN5 ^@ http://purl.uniprot.org/uniprot/A8E6E0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9258:POLR2F ^@ http://purl.uniprot.org/uniprot/A0A6I8P5I5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.|||Nucleus http://togogenome.org/gene/9258:BAG6 ^@ http://purl.uniprot.org/uniprot/A7X5R6 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome. SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome. BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response. BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress. By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis. Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway.|||Component of the BAG6/BAT3 complex, also named BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35. Interacts with GET4; the interaction is direct and localizes BAG6 in the cytosol. Interacts with UBL4A; the interaction is direct and required for UBL4A protein stability. Interacts with AIFM1. Interacts with HSPA2. Interacts with CTCFL. Interacts with p300/EP300. Interacts (via ubiquitin-like domain) with RNF126; required for BAG6-dependent ubiquitination of proteins mislocalized to the cytosol. Interacts (via ubiquitin-like domain) with SGTA; SGTA competes with RNF126 by binding the same region of BAG6, thereby promoting deubiquitination of BAG6-target proteins and rescuing them from degradation. Interacts with ricin A chain. Interacts with VCP and AMFR; both form the VCP/p97-AMFR/gp78 complex. Interacts with SYVN1. Interacts with USP13; the interaction is direct and may mediate UBL4A deubiquitination. Interacts with ZFAND2B. Interacts with KPNA2. Interacts with UBQLN4 (By similarity).|||Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity. When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2).|||May mediate ricin-induced apoptosis.|||Nucleus|||Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).|||Ricin can induce the cleavage by the caspase CASP3.|||The ubiquitin-like domain mediates interaction with the E3 ubiquitin-protein ligase RNF126 which is responsible for the BAG6-dependent ubiquitination of client proteins. SGTA also binds this domain and competes with RNF126 to antagonize client protein ubiquitination and degradation. The ubiquitin-like domain also mediates the interaction with USP13.|||cytosol|||extracellular exosome http://togogenome.org/gene/9258:FAM219B ^@ http://purl.uniprot.org/uniprot/A0A6I8NGV1 ^@ Similarity ^@ Belongs to the FAM219 family. http://togogenome.org/gene/9258:LOC100086581 ^@ http://purl.uniprot.org/uniprot/A0A6I8PG98 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:CFAP206 ^@ http://purl.uniprot.org/uniprot/A0A6I8PHN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP206 family.|||cilium axoneme http://togogenome.org/gene/9258:CSE1L ^@ http://purl.uniprot.org/uniprot/F6XDL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPO2/CSE1 family.|||Cytoplasm http://togogenome.org/gene/9258:RPSA ^@ http://purl.uniprot.org/uniprot/F7EXW2 ^@ Caution|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.|||Belongs to the universal ribosomal protein uS2 family.|||Cell membrane|||Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.|||Nucleus|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.|||This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. http://togogenome.org/gene/9258:GALNT5 ^@ http://purl.uniprot.org/uniprot/F6WTJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9258:LOC100093239 ^@ http://purl.uniprot.org/uniprot/A0A6I8N7N1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:KATNAL2 ^@ http://purl.uniprot.org/uniprot/F7DX12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.|||Cytoplasm|||Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9258:KEF28_p02 ^@ http://purl.uniprot.org/uniprot/Q36460 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 6 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane http://togogenome.org/gene/9258:PABPC4 ^@ http://purl.uniprot.org/uniprot/F6ZQ23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/9258:CPM ^@ http://purl.uniprot.org/uniprot/F7CJD4 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9258:GPR142 ^@ http://purl.uniprot.org/uniprot/F7B822 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9258:DUSP7 ^@ http://purl.uniprot.org/uniprot/A0A6I8NDY0 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9258:RPL13 ^@ http://purl.uniprot.org/uniprot/F6Q2G5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/9258:GRHL1 ^@ http://purl.uniprot.org/uniprot/A0A6I8MY05 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:LOC100077204 ^@ http://purl.uniprot.org/uniprot/F7D6K9 ^@ Similarity ^@ Belongs to the BicD family. http://togogenome.org/gene/9258:PSMA4 ^@ http://purl.uniprot.org/uniprot/F6Z866 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9258:STX17 ^@ http://purl.uniprot.org/uniprot/A0A6I8NGJ5|||http://purl.uniprot.org/uniprot/A0A6I8NJC5 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9258:MYOC ^@ http://purl.uniprot.org/uniprot/F6RC11 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9258:PPIE ^@ http://purl.uniprot.org/uniprot/A0A6I8N7N7 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.|||Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. http://togogenome.org/gene/9258:POU5F1 ^@ http://purl.uniprot.org/uniprot/A7X5W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9258:BAMBI ^@ http://purl.uniprot.org/uniprot/F6QKK9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BAMBI family.|||Membrane|||Negatively regulates TGF-beta signaling. http://togogenome.org/gene/9258:ORNANAV1R3047 ^@ http://purl.uniprot.org/uniprot/A0A6I8NWT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:POGLUT2 ^@ http://purl.uniprot.org/uniprot/F7CT27 ^@ Similarity ^@ Belongs to the KDELC family. http://togogenome.org/gene/9258:GNG2 ^@ http://purl.uniprot.org/uniprot/F6VPY1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9258:ORNANAV1R3174 ^@ http://purl.uniprot.org/uniprot/A0A6I8NEW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100077596 ^@ http://purl.uniprot.org/uniprot/F6VER0 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:MTMR2 ^@ http://purl.uniprot.org/uniprot/F7A9U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/9258:ORNANAV1R3267 ^@ http://purl.uniprot.org/uniprot/A0A6I8P3Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100076538 ^@ http://purl.uniprot.org/uniprot/F7GA33 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9258:SLC25A25 ^@ http://purl.uniprot.org/uniprot/A0A6I8MX71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9258:SUSD4 ^@ http://purl.uniprot.org/uniprot/F7G838 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9258:LOC100680750 ^@ http://purl.uniprot.org/uniprot/F7DNX4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:KCNS1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NK09 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:TMCO3 ^@ http://purl.uniprot.org/uniprot/F7G4E2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:B2M ^@ http://purl.uniprot.org/uniprot/Q864T7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta-2-microglobulin family.|||Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).|||Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).|||Secreted http://togogenome.org/gene/9258:LOC103169098 ^@ http://purl.uniprot.org/uniprot/A0A6I8PF74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:CAMK1 ^@ http://purl.uniprot.org/uniprot/F7FPX0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9258:SEC23A ^@ http://purl.uniprot.org/uniprot/F6SYZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9258:RAD23A ^@ http://purl.uniprot.org/uniprot/A0A6I8N6B5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/9258:ST7 ^@ http://purl.uniprot.org/uniprot/Q07DZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/9258:SV2B ^@ http://purl.uniprot.org/uniprot/A0A6I8NPQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9258:GRIA1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NS08|||http://purl.uniprot.org/uniprot/F6YAX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9258:CAPN2 ^@ http://purl.uniprot.org/uniprot/F7F9H3 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9258:SGCA ^@ http://purl.uniprot.org/uniprot/F6UNV1 ^@ Function|||Similarity ^@ Belongs to the sarcoglycan alpha/epsilon family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. http://togogenome.org/gene/9258:ORNANAV1R3098 ^@ http://purl.uniprot.org/uniprot/F6Z285 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:TUBA1B ^@ http://purl.uniprot.org/uniprot/A0A6I8P882 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9258:INSL3 ^@ http://purl.uniprot.org/uniprot/B1AAP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9258:ORNANAV1R3238 ^@ http://purl.uniprot.org/uniprot/F7GDH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:RHO ^@ http://purl.uniprot.org/uniprot/A4ZIS8 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Contains one covalently linked retinal chromophore.|||Membrane http://togogenome.org/gene/9258:ORNANAV1R3212 ^@ http://purl.uniprot.org/uniprot/A0A6I8N5V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100093330 ^@ http://purl.uniprot.org/uniprot/A0A6I8PF82 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:TBCC ^@ http://purl.uniprot.org/uniprot/A0A6I8NH03 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCC family.|||Cytoplasm|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. http://togogenome.org/gene/9258:GPR83 ^@ http://purl.uniprot.org/uniprot/A0A6I8PLQ1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9258:LOC103171054 ^@ http://purl.uniprot.org/uniprot/F7F050 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9258:PIAS1 ^@ http://purl.uniprot.org/uniprot/F7DN97 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/9258:LOC100089376 ^@ http://purl.uniprot.org/uniprot/F7DNX4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:LOC100089746 ^@ http://purl.uniprot.org/uniprot/F6Q8L3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9258:RAP2C ^@ http://purl.uniprot.org/uniprot/F7A1D4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/9258:KCNJ6 ^@ http://purl.uniprot.org/uniprot/F6WIC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.|||Membrane http://togogenome.org/gene/9258:ARPC4 ^@ http://purl.uniprot.org/uniprot/F7FPY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARPC4 family.|||Cell projection|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.|||cytoskeleton http://togogenome.org/gene/9258:LOC100093150 ^@ http://purl.uniprot.org/uniprot/F7DNX4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:MEIG1 ^@ http://purl.uniprot.org/uniprot/F6VDQ6 ^@ Function|||Similarity ^@ Belongs to the MEIG1 family.|||Essential for spermiogenesis. http://togogenome.org/gene/9258:RPL23 ^@ http://purl.uniprot.org/uniprot/A0A6I8PG80 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9258:LOC103168452 ^@ http://purl.uniprot.org/uniprot/A0A6I8NPI9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9258:CNOT8 ^@ http://purl.uniprot.org/uniprot/F6Z3Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/9258:MCHR2 ^@ http://purl.uniprot.org/uniprot/F7GE53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:MED4 ^@ http://purl.uniprot.org/uniprot/A0A6I8N6V0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 4 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9258:SH3BP4 ^@ http://purl.uniprot.org/uniprot/F7DJ60 ^@ Subcellular Location Annotation ^@ Nucleus|||Vesicle|||clathrin-coated pit|||clathrin-coated vesicle http://togogenome.org/gene/9258:SDE2 ^@ http://purl.uniprot.org/uniprot/F7F1N6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SDE2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9258:LOC100093220 ^@ http://purl.uniprot.org/uniprot/A0A6I8N7N1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:LOC100083813 ^@ http://purl.uniprot.org/uniprot/F6XEV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:RPS27L ^@ http://purl.uniprot.org/uniprot/A0A6I8NPD9 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9258:PTP4A2 ^@ http://purl.uniprot.org/uniprot/F7FFX5 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9258:ORNANAV1R3107 ^@ http://purl.uniprot.org/uniprot/F7G9L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:CCNJ ^@ http://purl.uniprot.org/uniprot/A0A6I8NFI9 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9258:ID2 ^@ http://purl.uniprot.org/uniprot/F7FSY1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:STC1 ^@ http://purl.uniprot.org/uniprot/F7EP00 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9258:PSKH1 ^@ http://purl.uniprot.org/uniprot/F6VN36 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9258:RPS17 ^@ http://purl.uniprot.org/uniprot/F7DYA2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/9258:LOC100077243 ^@ http://purl.uniprot.org/uniprot/F7B2V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9258:EMC3 ^@ http://purl.uniprot.org/uniprot/F7DLA1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC3 family.|||Component of the ER membrane protein complex (EMC).|||Membrane http://togogenome.org/gene/9258:CASK ^@ http://purl.uniprot.org/uniprot/A0A6I8N2K3 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/9258:WSCD1 ^@ http://purl.uniprot.org/uniprot/F7FLJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WSCD family.|||Golgi apparatus membrane|||Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. http://togogenome.org/gene/9258:ALDH2 ^@ http://purl.uniprot.org/uniprot/F7FFC7 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9258:SOAT1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NKQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9258:ORNANAV1R3141 ^@ http://purl.uniprot.org/uniprot/A0A6I8MZM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:MID1 ^@ http://purl.uniprot.org/uniprot/F6SKR8 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9258:LOC103164844 ^@ http://purl.uniprot.org/uniprot/A0A6I8PBW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Secreted http://togogenome.org/gene/9258:TM4SF20 ^@ http://purl.uniprot.org/uniprot/F6U9U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9258:TIMM10 ^@ http://purl.uniprot.org/uniprot/F6T7K0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9258:GPR146 ^@ http://purl.uniprot.org/uniprot/F6V2S4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9258:ZNF330 ^@ http://purl.uniprot.org/uniprot/F7BM32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOA36 family.|||centromere|||nucleolus http://togogenome.org/gene/9258:SPP2 ^@ http://purl.uniprot.org/uniprot/A0A6I8NPJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPP2 family.|||Could coordinate an aspect of bone turnover.|||Secreted http://togogenome.org/gene/9258:PRICKLE1 ^@ http://purl.uniprot.org/uniprot/F6U3C0 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/9258:LOC100093353 ^@ http://purl.uniprot.org/uniprot/A0A6I8N139 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:LOC100091379 ^@ http://purl.uniprot.org/uniprot/F6W205 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/9258:MPPED2 ^@ http://purl.uniprot.org/uniprot/K7EFC2 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/9258:PPIF ^@ http://purl.uniprot.org/uniprot/F6R1C3 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9258:PPIL1 ^@ http://purl.uniprot.org/uniprot/A0A6I8PCF1 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9258:MRPL15 ^@ http://purl.uniprot.org/uniprot/F6YQL1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/9258:LOC100083090 ^@ http://purl.uniprot.org/uniprot/F6XEE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:STN1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NMI2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the STN1 family.|||Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.|||Component of the CST complex.|||Nucleus|||telomere http://togogenome.org/gene/9258:UBA52 ^@ http://purl.uniprot.org/uniprot/F6SCZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Nucleus http://togogenome.org/gene/9258:EPC1 ^@ http://purl.uniprot.org/uniprot/A0A6I8PDR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/9258:KEF28_p07 ^@ http://purl.uniprot.org/uniprot/Q36455 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9258:RAD1 ^@ http://purl.uniprot.org/uniprot/F6UI60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad1 family.|||Nucleus http://togogenome.org/gene/9258:ORNANAV1R3093 ^@ http://purl.uniprot.org/uniprot/F7G2A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:DCLRE1C ^@ http://purl.uniprot.org/uniprot/F6VDP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9258:TBL1X ^@ http://purl.uniprot.org/uniprot/F6S036 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/9258:OPN1SW2 ^@ http://purl.uniprot.org/uniprot/A4ZIS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane|||Photoreceptor inner segment|||photoreceptor outer segment http://togogenome.org/gene/9258:HOXA9 ^@ http://purl.uniprot.org/uniprot/A0A6I8MXB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/9258:LOC100076644 ^@ http://purl.uniprot.org/uniprot/F6TGI1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9258:LOC100092493 ^@ http://purl.uniprot.org/uniprot/F6QWB7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9258:EOGT ^@ http://purl.uniprot.org/uniprot/A0A6I8P2Z7|||http://purl.uniprot.org/uniprot/F7ENU8 ^@ Similarity ^@ Belongs to the glycosyltransferase 61 family. http://togogenome.org/gene/9258:SLC9A4 ^@ http://purl.uniprot.org/uniprot/A0A6I8P858|||http://purl.uniprot.org/uniprot/F7F984 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Interacts with CHP1 and CHP2.|||Membrane http://togogenome.org/gene/9258:ROPN1L ^@ http://purl.uniprot.org/uniprot/F6YIJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ropporin family.|||flagellum http://togogenome.org/gene/9258:LOC100093210 ^@ http://purl.uniprot.org/uniprot/F6PX78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:ORNANAV1R3128 ^@ http://purl.uniprot.org/uniprot/A0A6I8N7K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:KIF1A ^@ http://purl.uniprot.org/uniprot/A0A6I8P315 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||axon http://togogenome.org/gene/9258:GPR137B ^@ http://purl.uniprot.org/uniprot/A0A6I8N6Z9 ^@ Subcellular Location Annotation ^@ Lysosome membrane|||Membrane http://togogenome.org/gene/9258:KPNA3 ^@ http://purl.uniprot.org/uniprot/F6W5W7 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9258:LOC100075061 ^@ http://purl.uniprot.org/uniprot/F6PYG8 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:NGDN ^@ http://purl.uniprot.org/uniprot/F7A2Y0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9258:KEF28_p11 ^@ http://purl.uniprot.org/uniprot/Q36452 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heme-copper respiratory oxidase family.|||Binds 2 heme A groups non-covalently per subunit.|||Binds a copper B center.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). As a newly synthesized protein, rapidly incorporates into a multi-subunit assembly intermediate in the inner membrane, called MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase) complex, whose core components are COA3/MITRAC12 and COX14. Within the MITRAC complex, interacts with COA3 and with SMIM20/MITRAC7; the interaction with SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its premature turnover. Interacts with TMEM177 in a COX20-dependent manner (By similarity).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9258:LPL ^@ http://purl.uniprot.org/uniprot/F7CIW2 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Cell membrane|||Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.|||Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.|||extracellular matrix http://togogenome.org/gene/9258:LOC100079889 ^@ http://purl.uniprot.org/uniprot/F6TZI4 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/9258:REXO2 ^@ http://purl.uniprot.org/uniprot/F7EJ45 ^@ Similarity ^@ Belongs to the oligoribonuclease family. http://togogenome.org/gene/9258:ORNANAV1R3123 ^@ http://purl.uniprot.org/uniprot/F6VH07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:VGLL4 ^@ http://purl.uniprot.org/uniprot/A0A6I8NY28 ^@ Function|||Similarity ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs. http://togogenome.org/gene/9258:TRARG1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NCK9 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9258:FAM20C ^@ http://purl.uniprot.org/uniprot/F7CXH9 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/9258:LOC100089121 ^@ http://purl.uniprot.org/uniprot/F7FZV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:RPL5 ^@ http://purl.uniprot.org/uniprot/F7FG88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/9258:HAO1 ^@ http://purl.uniprot.org/uniprot/F6VW26 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/9258:LOC100093204 ^@ http://purl.uniprot.org/uniprot/A0A6I8P814 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:TMEM45A ^@ http://purl.uniprot.org/uniprot/A0A6I8P1K5|||http://purl.uniprot.org/uniprot/F7CHV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9258:STARD3NL ^@ http://purl.uniprot.org/uniprot/F6XTA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Membrane http://togogenome.org/gene/9258:ORNANAV1R3108 ^@ http://purl.uniprot.org/uniprot/F6W5I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:OTC ^@ http://purl.uniprot.org/uniprot/A0A6I8PCR4 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily.|||Homotrimer. http://togogenome.org/gene/9258:SNTG1 ^@ http://purl.uniprot.org/uniprot/F7CKJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||cytoskeleton http://togogenome.org/gene/9258:ORNANAV1R3234 ^@ http://purl.uniprot.org/uniprot/A0A6I8NP31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100093163 ^@ http://purl.uniprot.org/uniprot/A0A6I8N139 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:YPEL4 ^@ http://purl.uniprot.org/uniprot/F7E6Q4 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9258:ACSL6 ^@ http://purl.uniprot.org/uniprot/A0A6I8N2T7|||http://purl.uniprot.org/uniprot/F7G6L5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion outer membrane http://togogenome.org/gene/9258:LOC100076650 ^@ http://purl.uniprot.org/uniprot/F7E1J1 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/9258:CWF19L1 ^@ http://purl.uniprot.org/uniprot/F6WA07 ^@ Similarity ^@ Belongs to the CWF19 family. http://togogenome.org/gene/9258:CD82 ^@ http://purl.uniprot.org/uniprot/A0A6I8P193 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9258:TAT ^@ http://purl.uniprot.org/uniprot/F6RG81 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. http://togogenome.org/gene/9258:PNRC2 ^@ http://purl.uniprot.org/uniprot/A0A6I8NS77 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:ARL5A ^@ http://purl.uniprot.org/uniprot/A0A6I8P6M5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9258:CHN2 ^@ http://purl.uniprot.org/uniprot/F7D0R2 ^@ Function ^@ GTPase-activating protein for p21-rac. http://togogenome.org/gene/9258:C2H12orf43 ^@ http://purl.uniprot.org/uniprot/F7DT61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUSTOS family.|||Nucleus envelope http://togogenome.org/gene/9258:STARD13 ^@ http://purl.uniprot.org/uniprot/F7B8Q1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9258:RCAN2 ^@ http://purl.uniprot.org/uniprot/A0A6I8N6N8|||http://purl.uniprot.org/uniprot/A0A6I8NCE8 ^@ Function|||Similarity ^@ Belongs to the RCAN family.|||Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. http://togogenome.org/gene/9258:PPARGC1A ^@ http://purl.uniprot.org/uniprot/A0A6I8NSB1 ^@ Subcellular Location Annotation ^@ PML body http://togogenome.org/gene/9258:ATP2B3 ^@ http://purl.uniprot.org/uniprot/F6QI04 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9258:GCNT3 ^@ http://purl.uniprot.org/uniprot/F6WVK0 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9258:BTK ^@ http://purl.uniprot.org/uniprot/F7BKT0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9258:SFXN2 ^@ http://purl.uniprot.org/uniprot/F7D0H7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9258:KIN ^@ http://purl.uniprot.org/uniprot/A0A6I8PH44 ^@ Similarity ^@ Belongs to the KIN17 family. http://togogenome.org/gene/9258:TLE4 ^@ http://purl.uniprot.org/uniprot/A0A6I8PCX9|||http://purl.uniprot.org/uniprot/A0A6I8PH51|||http://purl.uniprot.org/uniprot/F7EFU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/9258:LOC100084062 ^@ http://purl.uniprot.org/uniprot/F7C9W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/9258:EEF1G ^@ http://purl.uniprot.org/uniprot/A0A6I8NEF9 ^@ Function|||Subunit ^@ EF-1 is composed of four subunits: alpha, beta, delta, and gamma.|||Probably plays a role in anchoring the complex to other cellular components. http://togogenome.org/gene/9258:LOC100090093 ^@ http://purl.uniprot.org/uniprot/A0A6I8N664 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9258:LOC100078561 ^@ http://purl.uniprot.org/uniprot/K7EES2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/9258:LOC100086261 ^@ http://purl.uniprot.org/uniprot/A0A6I8N3G9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:SMPX ^@ http://purl.uniprot.org/uniprot/A0A6I8NF39 ^@ Function|||Similarity ^@ Belongs to the SMPX family.|||Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. http://togogenome.org/gene/9258:CHEK1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NUW9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. http://togogenome.org/gene/9258:YTHDF1 ^@ http://purl.uniprot.org/uniprot/F7DG05 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/9258:SLC9A2 ^@ http://purl.uniprot.org/uniprot/F7F968 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Interacts with CHP1 and CHP2.|||Membrane http://togogenome.org/gene/9258:TPH1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NSJ5 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/9258:MYMK ^@ http://purl.uniprot.org/uniprot/A0A6I8MZV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:CDC26 ^@ http://purl.uniprot.org/uniprot/F7ALV7 ^@ Function|||Similarity ^@ Belongs to the CDC26 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. http://togogenome.org/gene/9258:PSMB11 ^@ http://purl.uniprot.org/uniprot/F7ECE8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9258:LOC100078585 ^@ http://purl.uniprot.org/uniprot/A7X5N3 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9258:COPS5 ^@ http://purl.uniprot.org/uniprot/A0A6I8NTU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN5 subfamily.|||synaptic vesicle http://togogenome.org/gene/9258:B4GAT1 ^@ http://purl.uniprot.org/uniprot/F7E7G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 49 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9258:ORNANAV1R3236 ^@ http://purl.uniprot.org/uniprot/A0A6I8NV00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:NLGN4X ^@ http://purl.uniprot.org/uniprot/A0A6I8PQR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:ORNANAV1R3014 ^@ http://purl.uniprot.org/uniprot/A0A6I8P899 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:AP1G1 ^@ http://purl.uniprot.org/uniprot/A0A6I8PI71 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9258:CACNB4 ^@ http://purl.uniprot.org/uniprot/A0A6I8N9C0|||http://purl.uniprot.org/uniprot/A0A6I8P1X2|||http://purl.uniprot.org/uniprot/B6IDG4 ^@ Similarity ^@ Belongs to the calcium channel beta subunit family. http://togogenome.org/gene/9258:TMEM182 ^@ http://purl.uniprot.org/uniprot/F7F954 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM182 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:ORNANAV1R3008 ^@ http://purl.uniprot.org/uniprot/F7BJD9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9258:LDHA ^@ http://purl.uniprot.org/uniprot/Q7YQK6 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9258:TMEM11 ^@ http://purl.uniprot.org/uniprot/F6PX52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM11 family.|||Membrane|||Plays a role in mitochondrial morphogenesis. http://togogenome.org/gene/9258:ENO1 ^@ http://purl.uniprot.org/uniprot/F7FAQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9258:CLDN5 ^@ http://purl.uniprot.org/uniprot/F7DGF8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9258:SPON2 ^@ http://purl.uniprot.org/uniprot/F6YV63 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9258:LOC100079040 ^@ http://purl.uniprot.org/uniprot/F7FFR0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9258:GRB10 ^@ http://purl.uniprot.org/uniprot/A0A6I8NX22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/9258:ORNANAV1R3188 ^@ http://purl.uniprot.org/uniprot/A0A6I8MX55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:TFAP2D ^@ http://purl.uniprot.org/uniprot/F6U400 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/9258:C20H11orf54 ^@ http://purl.uniprot.org/uniprot/F6Z8K9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.|||Monomer.|||Nucleus http://togogenome.org/gene/9258:DDIT4 ^@ http://purl.uniprot.org/uniprot/A0A6I8P6W6 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/9258:LOC100083958 ^@ http://purl.uniprot.org/uniprot/F7FYV4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:EML6 ^@ http://purl.uniprot.org/uniprot/F7FJT4 ^@ Function|||Similarity ^@ Belongs to the WD repeat EMAP family.|||May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. http://togogenome.org/gene/9258:LOC100089146 ^@ http://purl.uniprot.org/uniprot/F7CP40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100079368 ^@ http://purl.uniprot.org/uniprot/F7G768 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:TPR ^@ http://purl.uniprot.org/uniprot/F6R964 ^@ Similarity ^@ Belongs to the TPR family. http://togogenome.org/gene/9258:RTRAF ^@ http://purl.uniprot.org/uniprot/F6VQ29 ^@ Similarity ^@ Belongs to the RTRAF family. http://togogenome.org/gene/9258:ACVR1C ^@ http://purl.uniprot.org/uniprot/F6W004 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9258:MRPS14 ^@ http://purl.uniprot.org/uniprot/A0A6I8N1W2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/9258:LOC100093356 ^@ http://purl.uniprot.org/uniprot/A0A6I8N139 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:LOC100093566 ^@ http://purl.uniprot.org/uniprot/A0A6I8N2P1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:LOC100082027 ^@ http://purl.uniprot.org/uniprot/A0A6I8NM90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100093192 ^@ http://purl.uniprot.org/uniprot/F6PX78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:ORNANAV1R3030 ^@ http://purl.uniprot.org/uniprot/F6TCZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:ORNANAV1R3064 ^@ http://purl.uniprot.org/uniprot/A0A6I8MZS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100080278 ^@ http://purl.uniprot.org/uniprot/F6VNE8 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/9258:LOC100075293 ^@ http://purl.uniprot.org/uniprot/F7F399 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Binds 2 Zn(2+) ions per subunit.|||Cytoplasm http://togogenome.org/gene/9258:IP6K2 ^@ http://purl.uniprot.org/uniprot/F7FEM8 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9258:SLC30A2 ^@ http://purl.uniprot.org/uniprot/F6W472 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9258:GET1 ^@ http://purl.uniprot.org/uniprot/A0A6I8PHA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WRB/GET1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9258:DHRS9 ^@ http://purl.uniprot.org/uniprot/F6WND2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9258:RTCB ^@ http://purl.uniprot.org/uniprot/F6X5L9 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Catalytic component of the tRNA-splicing ligase complex.|||Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.|||Cytoplasm|||Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP. http://togogenome.org/gene/9258:SPG21 ^@ http://purl.uniprot.org/uniprot/A0A6I8NIT6 ^@ Function ^@ May play a role as a negative regulatory factor in CD4-dependent T-cell activation. http://togogenome.org/gene/9258:XKR9 ^@ http://purl.uniprot.org/uniprot/F7FT32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9258:MEAF6 ^@ http://purl.uniprot.org/uniprot/A0A6I8NBF5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EAF6 family.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.|||Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.|||kinetochore|||nucleolus http://togogenome.org/gene/9258:LOC100093232 ^@ http://purl.uniprot.org/uniprot/F6PX78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:IFN1 ^@ http://purl.uniprot.org/uniprot/A8E6D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9258:FGF6 ^@ http://purl.uniprot.org/uniprot/F7D173 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9258:ESRRG ^@ http://purl.uniprot.org/uniprot/A0A6I8NQJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9258:TSNAX ^@ http://purl.uniprot.org/uniprot/F7FPM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the translin family.|||Nucleus http://togogenome.org/gene/9258:RRS1 ^@ http://purl.uniprot.org/uniprot/F7FNC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRS1 family.|||Involved in ribosomal large subunit assembly.|||Nucleus http://togogenome.org/gene/9258:RUNX1T1 ^@ http://purl.uniprot.org/uniprot/A0A6I8N432|||http://purl.uniprot.org/uniprot/A0A6I8NR78|||http://purl.uniprot.org/uniprot/A0A6I8PEU4 ^@ Similarity ^@ Belongs to the CBFA2T family. http://togogenome.org/gene/9258:GABRB2 ^@ http://purl.uniprot.org/uniprot/A0A6I8NZY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9258:LOC100076093 ^@ http://purl.uniprot.org/uniprot/F6QKJ9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9258:LOC100079414 ^@ http://purl.uniprot.org/uniprot/A0A6I8PJK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9258:CHN1 ^@ http://purl.uniprot.org/uniprot/F6XIY5 ^@ Function ^@ GTPase-activating protein for p21-rac. http://togogenome.org/gene/9258:AP3M2 ^@ http://purl.uniprot.org/uniprot/F6ZDY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus http://togogenome.org/gene/9258:EEF1A2 ^@ http://purl.uniprot.org/uniprot/A0A6I8N4L0 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/9258:MMP2 ^@ http://purl.uniprot.org/uniprot/F7FCH2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||extracellular matrix http://togogenome.org/gene/9258:NME5 ^@ http://purl.uniprot.org/uniprot/F7FRU9 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9258:THNSL2 ^@ http://purl.uniprot.org/uniprot/F7B3V8 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/9258:CPSF2 ^@ http://purl.uniprot.org/uniprot/F6T6L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/9258:SLC5A12 ^@ http://purl.uniprot.org/uniprot/A0A6I8MYF8|||http://purl.uniprot.org/uniprot/F6T2V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100076942 ^@ http://purl.uniprot.org/uniprot/A0A6I8N139 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:GAS8 ^@ http://purl.uniprot.org/uniprot/F6TMR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC4 family.|||flagellum|||flagellum axoneme http://togogenome.org/gene/9258:TFCP2L1 ^@ http://purl.uniprot.org/uniprot/A0A6I8PIQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/9258:MINAR1 ^@ http://purl.uniprot.org/uniprot/F6THE0 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/9258:TMEM35B ^@ http://purl.uniprot.org/uniprot/A0A6I8PA78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/9258:LOC100074485 ^@ http://purl.uniprot.org/uniprot/F7DUU6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9258:EIF2S1 ^@ http://purl.uniprot.org/uniprot/A0A6I8PJL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2-alpha family.|||Stress granule http://togogenome.org/gene/9258:FBXO9 ^@ http://purl.uniprot.org/uniprot/F6TN74 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.|||Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation. http://togogenome.org/gene/9258:TLCD3B ^@ http://purl.uniprot.org/uniprot/F7DGF1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:KLC1 ^@ http://purl.uniprot.org/uniprot/A0A6I8PCS7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/9258:ORNANAV1R3255 ^@ http://purl.uniprot.org/uniprot/A0A6I8N2C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:TEX28 ^@ http://purl.uniprot.org/uniprot/A0A6I8NVN0 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9258:LOC103166906 ^@ http://purl.uniprot.org/uniprot/K7EAI7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Homodimer.|||Nucleus|||Transcription factor. http://togogenome.org/gene/9258:EPHA3 ^@ http://purl.uniprot.org/uniprot/F7EX10 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:LOC100086273 ^@ http://purl.uniprot.org/uniprot/F6PSG7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:CLIC2 ^@ http://purl.uniprot.org/uniprot/A0A6I8PSZ6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9258:INTS7 ^@ http://purl.uniprot.org/uniprot/F7BQ29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 7 family.|||Nucleus http://togogenome.org/gene/9258:LOC100093382 ^@ http://purl.uniprot.org/uniprot/A0A6I8N139 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:LOC100083161 ^@ http://purl.uniprot.org/uniprot/F7GA89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:DUSP10 ^@ http://purl.uniprot.org/uniprot/F7GDU1 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9258:LOC100680868 ^@ http://purl.uniprot.org/uniprot/A0A6I8P5R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100075884 ^@ http://purl.uniprot.org/uniprot/A0A6I8PG89 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9258:FGF13 ^@ http://purl.uniprot.org/uniprot/A0A6I8MXC5|||http://purl.uniprot.org/uniprot/A0A6I8N286 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9258:SLC1A2 ^@ http://purl.uniprot.org/uniprot/F6PQH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9258:SRP19 ^@ http://purl.uniprot.org/uniprot/A0A6I8NW72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP19 family.|||Cytoplasm http://togogenome.org/gene/9258:LOC100682172 ^@ http://purl.uniprot.org/uniprot/F7GAE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:TM4SF4 ^@ http://purl.uniprot.org/uniprot/F7F7Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9258:LOC100084723 ^@ http://purl.uniprot.org/uniprot/F7EN88 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9258:YPEL5 ^@ http://purl.uniprot.org/uniprot/A0A6I8NB31 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9258:BRCC3 ^@ http://purl.uniprot.org/uniprot/F7C9Y2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M67A family. BRCC36 subfamily.|||Binds 1 zinc ion per subunit.|||Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. In the BRISC complex, interacts directly with ABRAXAS2. Identified in a complex with ABRAXAS2 and NUMA1. The BRISC complex interacts with the CSN complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BABAM2 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. Interacts with BRCA1. Binds polyubiquitin. Interacts with PWWP2B. Interacts with HDAC1; this interaction is enhanced in the presence of PWWP2B.|||Cytoplasm|||Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.|||Nucleus|||spindle pole http://togogenome.org/gene/9258:MASP1 ^@ http://purl.uniprot.org/uniprot/A0A6I8PKP3|||http://purl.uniprot.org/uniprot/F6XMS5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9258:FIBIN ^@ http://purl.uniprot.org/uniprot/A0A6I8N9D7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FIBIN family.|||Endoplasmic reticulum|||Golgi apparatus|||Homodimer; disulfide-linked. Seems to also exist as monomers.|||Secreted http://togogenome.org/gene/9258:SLC25A15 ^@ http://purl.uniprot.org/uniprot/A0A6I8PFJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9258:LOC100089603 ^@ http://purl.uniprot.org/uniprot/F7GC54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9258:NPPA ^@ http://purl.uniprot.org/uniprot/F6TF44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the natriuretic peptide family.|||Cell projection|||Homodimer; disulfide-linked antiparallel dimer.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.|||May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.|||Secreted http://togogenome.org/gene/9258:DGKE ^@ http://purl.uniprot.org/uniprot/F6TEN0 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9258:GDNF ^@ http://purl.uniprot.org/uniprot/F6X835 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/9258:ELOF1 ^@ http://purl.uniprot.org/uniprot/F7C8K1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELOF1 family.|||Nucleus|||Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. http://togogenome.org/gene/9258:LOC100083206 ^@ http://purl.uniprot.org/uniprot/F6X7U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9258:ORNANAV1R3249 ^@ http://purl.uniprot.org/uniprot/A0A6I8NZ92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:RAB14 ^@ http://purl.uniprot.org/uniprot/A0A6I8NCW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Recycling endosome|||phagosome|||trans-Golgi network membrane http://togogenome.org/gene/9258:BDKRB1 ^@ http://purl.uniprot.org/uniprot/F6R303 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. http://togogenome.org/gene/9258:SEC61A1 ^@ http://purl.uniprot.org/uniprot/F7G1S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9258:CDK20 ^@ http://purl.uniprot.org/uniprot/F6Y2P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||cilium http://togogenome.org/gene/9258:ORNANAV1R3049 ^@ http://purl.uniprot.org/uniprot/F7CML3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:RPS19 ^@ http://purl.uniprot.org/uniprot/F7DVV4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS19 family. http://togogenome.org/gene/9258:LAP3 ^@ http://purl.uniprot.org/uniprot/F6XA92 ^@ Similarity|||Subunit ^@ Belongs to the peptidase M17 family.|||Homohexamer. http://togogenome.org/gene/9258:KDM4A ^@ http://purl.uniprot.org/uniprot/F6XDU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM3 histone demethylase family.|||Nucleus http://togogenome.org/gene/9258:EMX2 ^@ http://purl.uniprot.org/uniprot/A0A6I8PAK7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:SLC46A2 ^@ http://purl.uniprot.org/uniprot/F6YJB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:MYF6 ^@ http://purl.uniprot.org/uniprot/F7DJU2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:GPR34 ^@ http://purl.uniprot.org/uniprot/F7DPA1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9258:CAPZA2 ^@ http://purl.uniprot.org/uniprot/Q07E00 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).|||Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP (By similarity). http://togogenome.org/gene/9258:IFT57 ^@ http://purl.uniprot.org/uniprot/F6QKV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT57 family.|||cilium basal body http://togogenome.org/gene/9258:LOC100093365 ^@ http://purl.uniprot.org/uniprot/A0A6I8NTJ4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:EXOSC2 ^@ http://purl.uniprot.org/uniprot/F6QCI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP4 family.|||Cytoplasm http://togogenome.org/gene/9258:MPP7 ^@ http://purl.uniprot.org/uniprot/A0A6I8P3S5|||http://purl.uniprot.org/uniprot/F6QL81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||adherens junction|||tight junction http://togogenome.org/gene/9258:ACBD5 ^@ http://purl.uniprot.org/uniprot/F6QLI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.|||Belongs to the ATG37 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9258:HMGB3 ^@ http://purl.uniprot.org/uniprot/A0A6I8P7X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/9258:STAR ^@ http://purl.uniprot.org/uniprot/F6UVJ9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ May interact with TSPO.|||Mitochondrion|||Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. http://togogenome.org/gene/9258:LOC100081236 ^@ http://purl.uniprot.org/uniprot/A0A6I8PNY6 ^@ Similarity ^@ Belongs to the SEC2 family. http://togogenome.org/gene/9258:NR0B2 ^@ http://purl.uniprot.org/uniprot/K7E9L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9258:LOC100090698 ^@ http://purl.uniprot.org/uniprot/A0A6I8PF82 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:FASLG ^@ http://purl.uniprot.org/uniprot/F6RBI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tumor necrosis factor family.|||Cell membrane|||Cytoplasmic form induces gene transcription inhibition.|||Cytoplasmic vesicle lumen|||Lysosome lumen|||Nucleus|||Secreted http://togogenome.org/gene/9258:HAL ^@ http://purl.uniprot.org/uniprot/F6Q611 ^@ Similarity ^@ Belongs to the PAL/histidase family. http://togogenome.org/gene/9258:IER2 ^@ http://purl.uniprot.org/uniprot/A0A6I8N3B6 ^@ Similarity ^@ Belongs to the IER family. http://togogenome.org/gene/9258:LOC100093142 ^@ http://purl.uniprot.org/uniprot/F7DNX4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:LOC100082886 ^@ http://purl.uniprot.org/uniprot/F7GAK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:CCN1 ^@ http://purl.uniprot.org/uniprot/F7F191 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9258:LOC100087385 ^@ http://purl.uniprot.org/uniprot/F7FHT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:TPRG1 ^@ http://purl.uniprot.org/uniprot/F7DUR8 ^@ Similarity ^@ Belongs to the TPRG1 family. http://togogenome.org/gene/9258:NR1H4 ^@ http://purl.uniprot.org/uniprot/F6PYB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9258:RAB18 ^@ http://purl.uniprot.org/uniprot/A0A6I8P127 ^@ Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Lipid droplet http://togogenome.org/gene/9258:CTBP1 ^@ http://purl.uniprot.org/uniprot/F6YV22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/9258:EXOC2 ^@ http://purl.uniprot.org/uniprot/F6R680 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SEC5 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||Component of the exocyst complex. http://togogenome.org/gene/9258:HNRNPK ^@ http://purl.uniprot.org/uniprot/F7EHL0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||nucleoplasm|||podosome http://togogenome.org/gene/9258:LOC100074778 ^@ http://purl.uniprot.org/uniprot/F7E0A6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9258:ACKR3 ^@ http://purl.uniprot.org/uniprot/F7AW12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100084402 ^@ http://purl.uniprot.org/uniprot/F6VVV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.|||Membrane|||Microsome membrane http://togogenome.org/gene/9258:RRM1 ^@ http://purl.uniprot.org/uniprot/F6U4A0 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/9258:ORNANAV1R3105 ^@ http://purl.uniprot.org/uniprot/A0A6I8NX09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:SSTR3 ^@ http://purl.uniprot.org/uniprot/F7FHB0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9258:KIF5B ^@ http://purl.uniprot.org/uniprot/F6PPG1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9258:GLUL ^@ http://purl.uniprot.org/uniprot/A0A6I8PF24 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/9258:LPIN2 ^@ http://purl.uniprot.org/uniprot/F7EDH5 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/9258:THEMIS2 ^@ http://purl.uniprot.org/uniprot/F6T5T5 ^@ Similarity ^@ Belongs to the themis family. http://togogenome.org/gene/9258:ORNANAV1R3254 ^@ http://purl.uniprot.org/uniprot/A0A6I8NKB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:ALG5 ^@ http://purl.uniprot.org/uniprot/F6Y0V8 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/9258:F9 ^@ http://purl.uniprot.org/uniprot/F6S689 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9258:ORNANAV1R3003 ^@ http://purl.uniprot.org/uniprot/A0A6I8N0A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:ARL6IP5 ^@ http://purl.uniprot.org/uniprot/F7EX01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/9258:S100Z ^@ http://purl.uniprot.org/uniprot/F7G3H7 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9258:LOC100080892 ^@ http://purl.uniprot.org/uniprot/F6ZYI9 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9258:SETDB2 ^@ http://purl.uniprot.org/uniprot/F6W5R9 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/9258:PDCD11 ^@ http://purl.uniprot.org/uniprot/F7DAV0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9258:PHLDA3 ^@ http://purl.uniprot.org/uniprot/F7G6A0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9258:CEP20 ^@ http://purl.uniprot.org/uniprot/F6WGN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP43 family.|||centriole|||cilium basal body http://togogenome.org/gene/9258:LOC100074423 ^@ http://purl.uniprot.org/uniprot/A0A6I8NUD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100090733 ^@ http://purl.uniprot.org/uniprot/A0A6I8NGX5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:FAM110C ^@ http://purl.uniprot.org/uniprot/A0A6I8NBB3 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/9258:PSMA7 ^@ http://purl.uniprot.org/uniprot/F6VA36 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9258:ORNANAV1R3160 ^@ http://purl.uniprot.org/uniprot/F7F387 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100085082 ^@ http://purl.uniprot.org/uniprot/A0A6I8P3U1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:KEF28_p05 ^@ http://purl.uniprot.org/uniprot/Q36457 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4L family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.|||Mitochondrion inner membrane http://togogenome.org/gene/9258:NME7 ^@ http://purl.uniprot.org/uniprot/A0A6I8N5N1|||http://purl.uniprot.org/uniprot/F6YIW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||cilium axoneme http://togogenome.org/gene/9258:NR2C1 ^@ http://purl.uniprot.org/uniprot/F6Q511 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9258:PHTF2 ^@ http://purl.uniprot.org/uniprot/F6PRC2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:RPS25 ^@ http://purl.uniprot.org/uniprot/F6SC43 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS25 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/9258:NUDT3 ^@ http://purl.uniprot.org/uniprot/F6W8P7 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/9258:DTWD2 ^@ http://purl.uniprot.org/uniprot/A0A6I8NPA2 ^@ Similarity ^@ Belongs to the TDD superfamily. DTWD2 family. http://togogenome.org/gene/9258:LOC100081672 ^@ http://purl.uniprot.org/uniprot/F7ET78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Membrane http://togogenome.org/gene/9258:ORNANAV1R3007 ^@ http://purl.uniprot.org/uniprot/F7BJ89 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9258:LOC100682157 ^@ http://purl.uniprot.org/uniprot/F7GAE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:JAG1 ^@ http://purl.uniprot.org/uniprot/F6VUQ4 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/9258:CPVL ^@ http://purl.uniprot.org/uniprot/A0A6I8NPM2|||http://purl.uniprot.org/uniprot/F7D0S5 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/9258:RMI1 ^@ http://purl.uniprot.org/uniprot/F6ZMF2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RMI1 family.|||Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.|||Nucleus http://togogenome.org/gene/9258:NR2C2 ^@ http://purl.uniprot.org/uniprot/A0A6I8PFQ4|||http://purl.uniprot.org/uniprot/F7AE27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9258:SPACA4 ^@ http://purl.uniprot.org/uniprot/F7A6Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPACA4/bouncer family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:ANAPC4 ^@ http://purl.uniprot.org/uniprot/F6VID4 ^@ Function|||Similarity ^@ Belongs to the APC4 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/9258:LOC100091117 ^@ http://purl.uniprot.org/uniprot/A0A6I8N3D7 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9258:EDNRA ^@ http://purl.uniprot.org/uniprot/F6VIX5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/9258:LOC100081512 ^@ http://purl.uniprot.org/uniprot/F7G1E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:ORNANAV1R3251 ^@ http://purl.uniprot.org/uniprot/A0A6I8P703 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:PTK6 ^@ http://purl.uniprot.org/uniprot/F7FTR4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9258:LOC100074166 ^@ http://purl.uniprot.org/uniprot/A0A6I8NAG4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9258:SKA2 ^@ http://purl.uniprot.org/uniprot/A0A6I8N2Y4|||http://purl.uniprot.org/uniprot/A0A6I8NB94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SKA2 family.|||spindle http://togogenome.org/gene/9258:LOC100086552 ^@ http://purl.uniprot.org/uniprot/A0A6I8PMV1 ^@ Function|||Subunit ^@ In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9258:KCMF1 ^@ http://purl.uniprot.org/uniprot/F6PV34 ^@ Function|||Similarity ^@ Belongs to the KCMF1 family.|||Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination. http://togogenome.org/gene/9258:ORNANAV1R3043 ^@ http://purl.uniprot.org/uniprot/A0A6I8P939 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:ORNANAV1R3262 ^@ http://purl.uniprot.org/uniprot/A0A6I8PFK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:PENK ^@ http://purl.uniprot.org/uniprot/F6VPS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Secreted|||chromaffin granule lumen http://togogenome.org/gene/9258:TECRL ^@ http://purl.uniprot.org/uniprot/F7F004 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Membrane http://togogenome.org/gene/9258:FGF4 ^@ http://purl.uniprot.org/uniprot/A0A6I8NM05 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9258:KEF28_p09 ^@ http://purl.uniprot.org/uniprot/Q36453 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase protein 8 family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with PRICKLE3 (By similarity).|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).|||Mitochondrion membrane http://togogenome.org/gene/9258:DYNC1H1 ^@ http://purl.uniprot.org/uniprot/F6X0U8 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/9258:NMUR2 ^@ http://purl.uniprot.org/uniprot/F6YAW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/9258:ORNANAV1R3130 ^@ http://purl.uniprot.org/uniprot/A0A6I8N1I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:MRPL51 ^@ http://purl.uniprot.org/uniprot/F6TAG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL51 family.|||Mitochondrion http://togogenome.org/gene/9258:BMP2 ^@ http://purl.uniprot.org/uniprot/A0A6I8NNW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/9258:KDELR2 ^@ http://purl.uniprot.org/uniprot/F6RQH9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9258:LOC100075034 ^@ http://purl.uniprot.org/uniprot/F6WRY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hcp beta-lactamase family.|||Mitochondrion intermembrane space|||Required for assembly of mitochondrial respiratory chain complexes. http://togogenome.org/gene/9258:LOC100084187 ^@ http://purl.uniprot.org/uniprot/F7FYL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:GALR1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NHZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9258:NDC80 ^@ http://purl.uniprot.org/uniprot/F6QUM4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NDC80/HEC1 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/9258:SMU1 ^@ http://purl.uniprot.org/uniprot/F6Z044 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SMU1 family.|||Nucleus speckle http://togogenome.org/gene/9258:ST3GAL5 ^@ http://purl.uniprot.org/uniprot/A0A0F7RQT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9258:GABRA6 ^@ http://purl.uniprot.org/uniprot/F7FRW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9258:SCGB1A1 ^@ http://purl.uniprot.org/uniprot/F6YRI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the secretoglobin family.|||Secreted http://togogenome.org/gene/9258:SCARA5 ^@ http://purl.uniprot.org/uniprot/F7EEJ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCARA5 family.|||Cell membrane|||Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).|||Homotrimer.|||Membrane http://togogenome.org/gene/9258:ORNANAV1R3237 ^@ http://purl.uniprot.org/uniprot/A0A6I8PF73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100093270 ^@ http://purl.uniprot.org/uniprot/A0A6I8N139 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:CEBPG ^@ http://purl.uniprot.org/uniprot/F7EWR3 ^@ Similarity ^@ Belongs to the bZIP family. C/EBP subfamily. http://togogenome.org/gene/9258:LOC100073518 ^@ http://purl.uniprot.org/uniprot/F7G3K3 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9258:LOC100078687 ^@ http://purl.uniprot.org/uniprot/F7EDX1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:FSHB ^@ http://purl.uniprot.org/uniprot/A0A6I8N0P4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9258:FGB ^@ http://purl.uniprot.org/uniprot/F7CSS4 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/9258:MAGOH ^@ http://purl.uniprot.org/uniprot/F6SH35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/9258:KEF28_p13 ^@ http://purl.uniprot.org/uniprot/Q37717 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 1 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).|||Mitochondrion inner membrane http://togogenome.org/gene/9258:HDHD2 ^@ http://purl.uniprot.org/uniprot/F7DX02 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9258:LOC100092684 ^@ http://purl.uniprot.org/uniprot/F6U6H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9258:CKMT2 ^@ http://purl.uniprot.org/uniprot/F7EGQ7 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9258:DDX4 ^@ http://purl.uniprot.org/uniprot/G0XSV8 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9258:ORNANAV1R3250 ^@ http://purl.uniprot.org/uniprot/A0A6I8PAI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:THNSL1 ^@ http://purl.uniprot.org/uniprot/F6V5M8 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/9258:CPB2 ^@ http://purl.uniprot.org/uniprot/F7DZP9 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9258:F10 ^@ http://purl.uniprot.org/uniprot/Q9GMD9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9258:CDH12 ^@ http://purl.uniprot.org/uniprot/F6VEV5 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:IL10 ^@ http://purl.uniprot.org/uniprot/A0A6I8N7H8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9258:TERT ^@ http://purl.uniprot.org/uniprot/F2YSU1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reverse transcriptase family. Telomerase subfamily.|||Cytoplasm|||Nucleus|||PML body|||Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.|||The RNA-interacting domain 1 (RD1)/N-terminal extension (NTE) is required for interaction with the pseudoknot-template domain of each of TERC dimers. It contains anchor sites that bind primer nucleotides upstream of the RNA-DNA hybrid and is thus an essential determinant of repeat addition processivity.|||The RNA-interacting domain 2 (RD2) is essential for both interaction with the CR4-CR5 domain of TERC and for DNA synthesis.|||The primer grip sequence in the RT domain is required for telomerase activity and for stable association with short telomeric primers.|||nucleolus|||nucleoplasm|||telomere http://togogenome.org/gene/9258:LPGAT1 ^@ http://purl.uniprot.org/uniprot/F7CCP4 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9258:RIOX2 ^@ http://purl.uniprot.org/uniprot/F6TJS3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ROX family. MINA53 subfamily.|||Binds 1 Fe(2+) ion per subunit.|||Nucleus|||Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. http://togogenome.org/gene/9258:GBGT1 ^@ http://purl.uniprot.org/uniprot/A0A6I8N0I6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 6 family.|||Binds 1 Mn(2+) ion per subunit.|||Membrane http://togogenome.org/gene/9258:CLIC5 ^@ http://purl.uniprot.org/uniprot/A0A6I8N5Z3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9258:PROM1 ^@ http://purl.uniprot.org/uniprot/E9LZ02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/9258:MSR1 ^@ http://purl.uniprot.org/uniprot/A0A6I8N6E9|||http://purl.uniprot.org/uniprot/F6WYX0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:PPP3R1 ^@ http://purl.uniprot.org/uniprot/F6XMP0 ^@ Similarity ^@ Belongs to the calcineurin regulatory subunit family. http://togogenome.org/gene/9258:TMSB15B ^@ http://purl.uniprot.org/uniprot/F7BKI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9258:RAB3A ^@ http://purl.uniprot.org/uniprot/F6VQY7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9258:TSPAN18 ^@ http://purl.uniprot.org/uniprot/A0A6I8N493 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9258:BABAM2 ^@ http://purl.uniprot.org/uniprot/A0A6I8N8U9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BABAM2 family.|||Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.|||Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.|||Cytoplasm|||May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.|||Nucleus http://togogenome.org/gene/9258:LOC100083044 ^@ http://purl.uniprot.org/uniprot/F6Q2J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:CACNG1 ^@ http://purl.uniprot.org/uniprot/F7CV23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.|||Membrane|||Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.|||sarcolemma http://togogenome.org/gene/9258:POLR3F ^@ http://purl.uniprot.org/uniprot/F6XG18 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9258:LOC100083627 ^@ http://purl.uniprot.org/uniprot/A0A6I8PGF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9258:NRG1 ^@ http://purl.uniprot.org/uniprot/A0A6I8P848 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neuregulin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9258:EXOSC9 ^@ http://purl.uniprot.org/uniprot/A0A6I8NAZ8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9258:OGG1 ^@ http://purl.uniprot.org/uniprot/A0A6I8PGM6 ^@ Function|||Similarity ^@ Belongs to the type-1 OGG1 family.|||DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. http://togogenome.org/gene/9258:SPA17 ^@ http://purl.uniprot.org/uniprot/A0A6I8ND67|||http://purl.uniprot.org/uniprot/Q6SJ92 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates. http://togogenome.org/gene/9258:SLC26A2 ^@ http://purl.uniprot.org/uniprot/A0A6I8N3P3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion. http://togogenome.org/gene/9258:CMC4 ^@ http://purl.uniprot.org/uniprot/F7C9Y9 ^@ Similarity ^@ Belongs to the CMC4 family. http://togogenome.org/gene/9258:LOC100090298 ^@ http://purl.uniprot.org/uniprot/A0A6I8N8F2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX16 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9258:PLAC8L1 ^@ http://purl.uniprot.org/uniprot/K7EH55 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9258:FUT9 ^@ http://purl.uniprot.org/uniprot/F7D2K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/9258:PLA2G4A ^@ http://purl.uniprot.org/uniprot/F6QDY0 ^@ Domain ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding. http://togogenome.org/gene/9258:MAPRE2 ^@ http://purl.uniprot.org/uniprot/F7C0X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/9258:LOC100093297 ^@ http://purl.uniprot.org/uniprot/A0A6I8PF82 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:LOC100093349 ^@ http://purl.uniprot.org/uniprot/A0A6I8N139 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:LDB2 ^@ http://purl.uniprot.org/uniprot/F7FZZ4 ^@ Similarity ^@ Belongs to the LDB family. http://togogenome.org/gene/9258:ASPN ^@ http://purl.uniprot.org/uniprot/F7CWY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||extracellular matrix http://togogenome.org/gene/9258:MYF5 ^@ http://purl.uniprot.org/uniprot/F7DJV8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/9258:LOC100093226 ^@ http://purl.uniprot.org/uniprot/A0A6I8N7N1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:TMEM14A ^@ http://purl.uniprot.org/uniprot/A0A6I8N849 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9258:LOC100093253 ^@ http://purl.uniprot.org/uniprot/A0A6I8N7N1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:IFN4 ^@ http://purl.uniprot.org/uniprot/A8E6D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9258:IGF2BP3 ^@ http://purl.uniprot.org/uniprot/F7BHT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||P-body|||Stress granule http://togogenome.org/gene/9258:ZGPAT ^@ http://purl.uniprot.org/uniprot/F7E9I2 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CHD4/Mi-2; the interaction is direct.|||Nucleus http://togogenome.org/gene/9258:LOC100089396 ^@ http://purl.uniprot.org/uniprot/F7DNX4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:SPTSSB ^@ http://purl.uniprot.org/uniprot/A0A6I8NZ87 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9258:LOC103170898 ^@ http://purl.uniprot.org/uniprot/K7EGU8 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9258:SERPINC1 ^@ http://purl.uniprot.org/uniprot/F6QFN9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the serpin family.|||Forms protease inhibiting heterodimer with TMPRSS7.|||extracellular space http://togogenome.org/gene/9258:ORNANAV1R3131 ^@ http://purl.uniprot.org/uniprot/A0A6I8PEU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:TRH ^@ http://purl.uniprot.org/uniprot/A0A6I8P3Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRH family.|||Secreted http://togogenome.org/gene/9258:NQO1 ^@ http://purl.uniprot.org/uniprot/A0A6I8N977 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/9258:DTNBP1 ^@ http://purl.uniprot.org/uniprot/F6TUH2 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/9258:DDX50 ^@ http://purl.uniprot.org/uniprot/A0A6I8PGH6 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily. http://togogenome.org/gene/9258:LNPK ^@ http://purl.uniprot.org/uniprot/A0A6I8P7D7|||http://purl.uniprot.org/uniprot/F6XHY2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lunapark family.|||Endoplasmic reticulum membrane|||Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.|||Plays a role in determining ER morphology.|||The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation. http://togogenome.org/gene/9258:ARPC1B ^@ http://purl.uniprot.org/uniprot/F6QT91 ^@ Function|||Similarity ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. http://togogenome.org/gene/9258:LOC100089126 ^@ http://purl.uniprot.org/uniprot/A0A6I8N139 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:PTTG1 ^@ http://purl.uniprot.org/uniprot/F6VVC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the securin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9258:GRK1 ^@ http://purl.uniprot.org/uniprot/F7G4E7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9258:DOLPP1 ^@ http://purl.uniprot.org/uniprot/F7E622 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dolichyldiphosphatase family.|||Endoplasmic reticulum membrane|||Membrane|||Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. http://togogenome.org/gene/9258:LOC100085268 ^@ http://purl.uniprot.org/uniprot/F7A0R6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:ATP6V1D ^@ http://purl.uniprot.org/uniprot/A0A6I8P5K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase D subunit family.|||cilium|||clathrin-coated vesicle membrane http://togogenome.org/gene/9258:IFNB1 ^@ http://purl.uniprot.org/uniprot/A8E6E1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9258:RTN4 ^@ http://purl.uniprot.org/uniprot/A0A6I8NYA0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9258:NR2F2 ^@ http://purl.uniprot.org/uniprot/A0A6I8PC22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9258:STARD6 ^@ http://purl.uniprot.org/uniprot/A0A6I8NQ99 ^@ Function ^@ May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols. http://togogenome.org/gene/9258:PEPD ^@ http://purl.uniprot.org/uniprot/F7EWS1 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/9258:LOC100083516 ^@ http://purl.uniprot.org/uniprot/F7G4L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:RPL35A ^@ http://purl.uniprot.org/uniprot/F7FJB8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/9258:KEF28_p10 ^@ http://purl.uniprot.org/uniprot/Q37718 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a dinuclear copper A center per subunit.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16 (By similarity).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9258:ATG4C ^@ http://purl.uniprot.org/uniprot/F6PL45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/9258:LOC100079342 ^@ http://purl.uniprot.org/uniprot/F6QQD7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Basal cell membrane|||Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Interacts with PDZK1. http://togogenome.org/gene/9258:LOC100073653 ^@ http://purl.uniprot.org/uniprot/F7FG67 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARL2BP family.|||Cytoplasm|||Mitochondrion intermembrane space|||Nucleus|||Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.|||centrosome|||cilium basal body http://togogenome.org/gene/9258:LOC100093160 ^@ http://purl.uniprot.org/uniprot/F6PX78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9258:CYP1A1 ^@ http://purl.uniprot.org/uniprot/A0A6I8N405 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9258:LOC100076934 ^@ http://purl.uniprot.org/uniprot/F7FI82 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9258:LOC100087699 ^@ http://purl.uniprot.org/uniprot/F7GDF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:KCNA10 ^@ http://purl.uniprot.org/uniprot/F7A2P0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:ORNANAV1R3052 ^@ http://purl.uniprot.org/uniprot/F7D2N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:LOC100080576 ^@ http://purl.uniprot.org/uniprot/F7B1W2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9258:SGTA ^@ http://purl.uniprot.org/uniprot/F7E1T8 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/9258:GPR1 ^@ http://purl.uniprot.org/uniprot/F6QIU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9258:DYNLL2 ^@ http://purl.uniprot.org/uniprot/A0A6I8PHH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9258:CDC25B ^@ http://purl.uniprot.org/uniprot/F7DQ48 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/9258:MALL ^@ http://purl.uniprot.org/uniprot/F6TYK1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9258:CLTA ^@ http://purl.uniprot.org/uniprot/F7DGD9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/9258:LOC100079726 ^@ http://purl.uniprot.org/uniprot/F6V1L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9258:ST3GAL1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NMZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9258:SLC16A7 ^@ http://purl.uniprot.org/uniprot/F6SS38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9258:PSMB2 ^@ http://purl.uniprot.org/uniprot/F7CSY1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9258:LTB ^@ http://purl.uniprot.org/uniprot/A7X5T4 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9258:MET ^@ http://purl.uniprot.org/uniprot/Q07E01 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autophosphorylated in response to ligand binding on Tyr-1235 and Tyr-1236 in the kinase domain leading to further phosphorylation of Tyr-1350 and Tyr-1357 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1350 and Tyr-1366. Dephosphorylated by PTPN1 and PTPN2 (By similarity).|||Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1357, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity. Interacts with tensin TNS3 (By similarity). Interacts (when phosphorylated) with tensin TNS4 (via SH2 domain); the interaction increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation (By similarity).|||In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity (By similarity).|||Membrane|||O-mannosylation of IPT/TIG domains by TMEM260 is required for protein maturation. O-mannosylated residues are composed of single mannose glycans that are not elongated or modified.|||Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).|||The beta-propeller Sema domain mediates binding to HGF.|||The kinase domain is involved in SPSB1 binding.|||Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation (By similarity). http://togogenome.org/gene/9258:METTL2A ^@ http://purl.uniprot.org/uniprot/F6QF05 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9258:ATG16L1 ^@ http://purl.uniprot.org/uniprot/A0A6I8NZ85|||http://purl.uniprot.org/uniprot/A0A6I8P2E3|||http://purl.uniprot.org/uniprot/F7A1C6 ^@ Similarity ^@ Belongs to the WD repeat ATG16 family. http://togogenome.org/gene/9258:SV2C ^@ http://purl.uniprot.org/uniprot/A0A6I8NJ41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9258:SIX2 ^@ http://purl.uniprot.org/uniprot/F7C4U0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9258:POP7 ^@ http://purl.uniprot.org/uniprot/A0A6I8NRR4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone-like Alba family.|||Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.|||Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.|||Cytoplasmic granule|||nucleolus http://togogenome.org/gene/9258:CD36 ^@ http://purl.uniprot.org/uniprot/F7FSF4 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/9258:LOC100081857 ^@ http://purl.uniprot.org/uniprot/F6Y994 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9258:LOC100077197 ^@ http://purl.uniprot.org/uniprot/F7B3D4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9258:RBP2 ^@ http://purl.uniprot.org/uniprot/F6ZLK1 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.